This page shows the publications M. Arnaout has written about Disease Models, Animal.
The vasculopathy of autosomal dominant polycystic kidney disease: insights from animal models. Kidney Int. 2000 Dec; 58(6):2599-610.
Structure-guided design of pure orthosteric inhibitors of aIIbß3 that prevent thrombosis but preserve hemostasis. Nat Commun. 2020 01 21; 11(1):398.
Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys. Nat Commun. 2017 01 10; 8:13899.
Negative Regulation of TGFß Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury. PLoS One. 2015; 10(6):e0129561.
Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease. Annu Rev Med. 2001; 52:93-123.
Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1731-6.
uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 04 02; 129(5):1946-1959.
Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat. Immunology. 2006 Dec; 119(4):431-40.
A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J. 2005 Feb; 19(2):203-10.
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