Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

M. Amin Arnaout, M.D.

Concepts

This page shows the publications M. Arnaout has written about Animals.
Connection Strength

0.294
  1. Structure-guided design of pure orthosteric inhibitors of aIIbß3 that prevent thrombosis but preserve hemostasis. Nat Commun. 2020 01 21; 11(1):398.
    View in: PubMed
    Score: 0.022
  2. Prophylactic orthosteric inhibition of leukocyte integrin CD11b/CD18 prevents long-term fibrotic kidney failure in cynomolgus monkeys. Nat Commun. 2017 01 10; 8:13899.
    View in: PubMed
    Score: 0.018
  3. Negative Regulation of TGFß Signaling by Stem Cell Antigen-1 Protects against Ischemic Acute Kidney Injury. PLoS One. 2015; 10(6):e0129561.
    View in: PubMed
    Score: 0.016
  4. Atomic basis for the species-specific inhibition of aV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of aVß3 ectodomain-17E6 Fab complex. J Biol Chem. 2014 May 16; 289(20):13801-9.
    View in: PubMed
    Score: 0.014
  5. Stress hematopoiesis is regulated by the Krüppel-like transcription factor ZBP-89. Stem Cells. 2014 Mar; 32(3):791-801.
    View in: PubMed
    Score: 0.014
  6. Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol. 2011 Dec 15; 187(12):6393-401.
    View in: PubMed
    Score: 0.012
  7. Structure and mechanics of integrin-based cell adhesion. Curr Opin Cell Biol. 2007 Oct; 19(5):495-507.
    View in: PubMed
    Score: 0.009
  8. The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood. 2007 Apr 15; 109(8):3513-20.
    View in: PubMed
    Score: 0.009
  9. The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells. Development. 2006 Sep; 133(18):3641-50.
    View in: PubMed
    Score: 0.009
  10. Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol. 2005; 21:381-410.
    View in: PubMed
    Score: 0.008
  11. The structural basis of elasticity in fibrillin-based microfibrils. Structure. 2004 May; 12(5):734-6.
    View in: PubMed
    Score: 0.007
  12. Integrins, cations and ligands: making the connection. J Thromb Haemost. 2003 Jul; 1(7):1642-54.
    View in: PubMed
    Score: 0.007
  13. Coming to grips with integrin binding to ligands. Curr Opin Cell Biol. 2002 Oct; 14(5):641-51.
    View in: PubMed
    Score: 0.007
  14. Integrin structure: new twists and turns in dynamic cell adhesion. Immunol Rev. 2002 Aug; 186:125-40.
    View in: PubMed
    Score: 0.006
  15. Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b. J Immunol. 2002 Feb 01; 168(3):1219-25.
    View in: PubMed
    Score: 0.006
  16. WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35. Genomics. 2002 Jan; 79(1):87-94.
    View in: PubMed
    Score: 0.006
  17. Polycystin-1 interacts with intermediate filaments. J Biol Chem. 2001 Dec 07; 276(49):46544-52.
    View in: PubMed
    Score: 0.006
  18. Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease. Annu Rev Med. 2001; 52:93-123.
    View in: PubMed
    Score: 0.006
  19. The vasculopathy of autosomal dominant polycystic kidney disease: insights from animal models. Kidney Int. 2000 Dec; 58(6):2599-610.
    View in: PubMed
    Score: 0.006
  20. Polycystin 1 is required for the structural integrity of blood vessels. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1731-6.
    View in: PubMed
    Score: 0.005
  21. uPAR isoform 2 forms a dimer and induces severe kidney disease in mice. J Clin Invest. 2019 04 02; 129(5):1946-1959.
    View in: PubMed
    Score: 0.005
  22. Functional analysis of the beta 2 integrins. Methods Mol Biol. 1999; 129:105-24.
    View in: PubMed
    Score: 0.005
  23. Two functional states of the CD11b A-domain: correlations with key features of two Mn2+-complexed crystal structures. J Cell Biol. 1998 Dec 14; 143(6):1523-34.
    View in: PubMed
    Score: 0.005
  24. Emerging paradigms of integrin ligand binding and activation. Kidney Int. 1997 May; 51(5):1454-62.
    View in: PubMed
    Score: 0.004
  25. Integrin-ligand interactions: scratching the surface. Curr Opin Hematol. 1997 Jan; 4(1):67-74.
    View in: PubMed
    Score: 0.004
  26. Characterization and cell distribution of polycystin, the product of autosomal dominant polycystic kidney disease gene 1. Mol Med. 1996 Nov; 2(6):702-11.
    View in: PubMed
    Score: 0.004
  27. Solvent-accessible residues on the metal ion-dependent adhesion site face of integrin CR3 mediate its binding to the neutrophil inhibitory factor. J Biol Chem. 1996 Jul 05; 271(27):15858-61.
    View in: PubMed
    Score: 0.004
  28. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish. FASEB J. 2015 Dec; 29(12):4989-5005.
    View in: PubMed
    Score: 0.004
  29. The A-domain of beta 2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J Cell Biol. 1994 Dec; 127(6 Pt 2):2081-91.
    View in: PubMed
    Score: 0.004
  30. Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18). Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10680-4.
    View in: PubMed
    Score: 0.004
  31. Collective epithelial migration drives kidney repair after acute injury. PLoS One. 2014; 9(7):e101304.
    View in: PubMed
    Score: 0.004
  32. Cytoplasmic tails of human complement receptor type 3 (CR3, CD11b/CD18) regulate ligand avidity and the internalization of occupied receptors. J Immunol. 1993 Jul 15; 151(2):990-1002.
    View in: PubMed
    Score: 0.003
  33. A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding. Cell. 1993 Mar 26; 72(6):857-67.
    View in: PubMed
    Score: 0.003
  34. Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins. J Biol Chem. 1992 Feb 15; 267(5):3351-7.
    View in: PubMed
    Score: 0.003
  35. The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. Prostaglandins Leukot Essent Fatty Acids. 2011 Jan-Feb; 84(1-2):43-50.
    View in: PubMed
    Score: 0.003
  36. Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis. Clin Exp Immunol. 2010 Mar; 159(3):327-37.
    View in: PubMed
    Score: 0.003
  37. Molecular cloning of the alpha subunit of human and guinea pig leukocyte adhesion glycoprotein Mo1: chromosomal localization and homology to the alpha subunits of integrins. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2776-80.
    View in: PubMed
    Score: 0.002
  38. N-terminal sequence of human leukocyte glycoprotein Mo1: conservation across species and homology to platelet IIb/IIIa. Biochim Biophys Acta. 1986 Dec 12; 874(3):368-71.
    View in: PubMed
    Score: 0.002
  39. Recombinant integrin CD11b A-domain blocks polymorphonuclear cells recruitment and protects against skeletal muscle inflammatory injury in the rat. Immunology. 2006 Dec; 119(4):431-40.
    View in: PubMed
    Score: 0.002
  40. Human recombinant granulocyte-macrophage colony-stimulating factor increases cell-to-cell adhesion and surface expression of adhesion-promoting surface glycoproteins on mature granulocytes. J Clin Invest. 1986 Aug; 78(2):597-601.
    View in: PubMed
    Score: 0.002
  41. Expression and purification of functional human anthrax toxin receptor (ATR/TEM8) binding domain from Escherichia coli. Protein Expr Purif. 2006 Sep; 49(1):121-8.
    View in: PubMed
    Score: 0.002
  42. Deficiency of two human leukocyte surface membrane glycoproteins (Mo1 and LFA-1). Fed Proc. 1985 Jul; 44(10):2664-70.
    View in: PubMed
    Score: 0.002
  43. A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J. 2005 Feb; 19(2):203-10.
    View in: PubMed
    Score: 0.002
  44. Deficiency of a leukocyte surface glycoprotein (LFA-1) in two patients with Mo1 deficiency. Effects of cell activation on Mo1/LFA-1 surface expression in normal and deficient leukocytes. J Clin Invest. 1984 Oct; 74(4):1291-300.
    View in: PubMed
    Score: 0.002
  45. Deficiency of a surface membrane glycoprotein (Mo1) in man. J Clin Invest. 1984 Jan; 73(1):153-9.
    View in: PubMed
    Score: 0.002
  46. Role of human factor I and C3b receptor in the cleavage of surface-bound C3bi molecules. Eur J Immunol. 1983 Jun; 13(6):465-70.
    View in: PubMed
    Score: 0.002
  47. Use of a bovine model to study the role of adhesion molecule CD11/CD18 in hemodialysis-induced neutropenia. Am J Kidney Dis. 2002 Mar; 39(3):587-93.
    View in: PubMed
    Score: 0.002
  48. Active immunization with lipopolysaccharide Pseudomonas antigen for chronic Pseudomonas bronchopneumonia in guinea pigs. J Clin Invest. 1981 Nov; 68(5):1140-8.
    View in: PubMed
    Score: 0.002
  49. Characterization of the human complement (c3b) receptor with a fluid phase C3b dimer. J Immunol. 1981 Oct; 127(4):1348-54.
    View in: PubMed
    Score: 0.002
  50. Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel. Proc Natl Acad Sci U S A. 2001 Jan 30; 98(3):1182-7.
    View in: PubMed
    Score: 0.001
  51. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000 Oct 15; 165(8):4272-80.
    View in: PubMed
    Score: 0.001
  52. The CD11/CD18 integrins: characterization of three novel LPS signaling receptors. Prog Clin Biol Res. 1998; 397:107-17.
    View in: PubMed
    Score: 0.001
  53. Outside-in signaling by lipopolysaccharide through a tailless integrin. J Immunol. 1997 Jul 01; 159(1):433-8.
    View in: PubMed
    Score: 0.001
  54. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec; 5(6):653-66.
    View in: PubMed
    Score: 0.001
  55. Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain. J Immunol. 1995 Oct 01; 155(7):3619-28.
    View in: PubMed
    Score: 0.001
  56. Preventing the infiltration of leukocytes by monoclonal antibody blocks the development of progressive ischemia in rat burns. Plast Reconstr Surg. 1995 Oct; 96(5):1177-85; discussion 1186-7.
    View in: PubMed
    Score: 0.001
  57. Anti-KCA-3, a monoclonal antibody reactive with a rat complement C3 receptor, distinguishes Kupffer cells from other macrophages. J Immunol. 1993 May 01; 150(9):4019-30.
    View in: PubMed
    Score: 0.001
  58. Effect of an anti-Mo1 MAb on ozone-induced airway inflammation and airway hyperresponsiveness in dogs. Am J Physiol. 1992 Dec; 263(6 Pt 1):L723-6.
    View in: PubMed
    Score: 0.001
  59. Cellular myosin heavy chain in human leukocytes: isolation of 5' cDNA clones, characterization of the protein, chromosomal localization, and upregulation during myeloid differentiation. Blood. 1991 Oct 01; 78(7):1826-33.
    View in: PubMed
    Score: 0.001
  60. Endocytic vesicles from renal papilla which retrieve the vasopressin-sensitive water channel do not contain a functional H+ ATPase. J Cell Biol. 1990 Aug; 111(2):379-89.
    View in: PubMed
    Score: 0.001
  61. Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes. Clin Immunol Immunopathol. 1988 Feb; 46(2):272-83.
    View in: PubMed
    Score: 0.001
  62. Subcellular localization of the large subunit of Mo1 (Mo1 alpha; formerly gp 110), a surface glycoprotein associated with neutrophil adhesion. J Clin Invest. 1984 Oct; 74(4):1280-90.
    View in: PubMed
    Score: 0.000
  63. Induction of granulocyte histaminase release by particle-bound complement C3 cleavage products (C3b, C3bi) and IgG. J Immunol. 1983 Jul; 131(1):439-44.
    View in: PubMed
    Score: 0.000
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.