Harvard Catalyst Profiles

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David I Kasahara, Ph.D.

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Other Positions

ATS Travel Award: Assembly on Environmental and Occupational Health

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kim SH, Mitchel JA, McGill M, Cremona TP, Baek JW, Kasahara DI, Anathy V, Israel E, Park JA. Elevated extracellular maspin after mechanical compression in vitro or allergen challenges in vivo. J Allergy Clin Immunol. 2019 Jun 19. PMID: 31228474.
  2. Tashiro H, Cho Y, Kasahara DI, Brand JD, Bry L, Yeliseyev V, Abu-Ali G, Huttenhower C, Shore SA. Microbiota contribute to obesity-related increases in the pulmonary response to ozone. Am J Respir Cell Mol Biol. 2019 May 30. PMID: 31144984.
  3. Cho Y, Abu-Ali G, Tashiro H, Brown TA, Osgood RS, Kasahara DI, Huttenhower C, Shore SA. Sex Differences in Pulmonary Responses to Ozone in Mice. Role of the Microbiome. Am J Respir Cell Mol Biol. 2019 Feb; 60(2):198-208. PMID: 30240285.
    Citations:    Fields:    
  4. Cho Y, Abu-Ali G, Tashiro H, Kasahara DI, Brown TA, Brand JD, Mathews JA, Huttenhower C, Shore SA. The Microbiome Regulates Pulmonary Responses to Ozone in Mice. Am J Respir Cell Mol Biol. 2018 09; 59(3):346-354. PMID: 29529379.
    Citations: 2     Fields:    
  5. Mathews JA, Krishnamoorthy N, Kasahara DI, Hutchinson J, Cho Y, Brand JD, Williams AS, Wurmbrand AP, Ribeiro L, Cuttitta F, Sunday ME, Levy BD, Shore SA. Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide. Am J Respir Cell Mol Biol. 2018 03; 58(3):341-351. PMID: 28957638.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Mathews JA, Kasahara DI, Cho Y, Bell LN, Gunst PR, Karoly ED, Shore SA. Effect of acute ozone exposure on the lung metabolomes of obese and lean mice. PLoS One. 2017; 12(7):e0181017. PMID: 28704544.
    Citations:    Fields:    Translation:AnimalsCells
  7. Kasahara DI, Mathews JA, Ninin FM, Wurmbrand AP, Liao JK, Shore SA. Role of ROCK2 in CD4+ cells in allergic airways responses in mice. Clin Exp Allergy. 2017 Feb; 47(2):224-235. PMID: 27886408.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Rosenblum Lichtenstein JH, Molina RM, Donaghey TC, Hsu YH, Mathews JA, Kasahara DI, Park JA, Bordini A, Godleski JJ, Gillis BS, Brain JD. Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response from Type 1 to Type 2. Am J Respir Cell Mol Biol. 2016 Oct; 55(4):521-531. PMID: 27148627.
    Citations: 2     Fields:    
  9. Mathews JA, Krishnamoorthy N, Kasahara DI, Cho Y, Wurmbrand AP, Ribeiro L, Smith D, Umetsu D, Levy BD, Shore SA. IL-33 Drives Augmented Responses to Ozone in Obese Mice. Environ Health Perspect. 2017 02; 125(2):246-253. PMID: 27472835.
    Citations: 8     Fields:    Translation:Animals
  10. Brand JD, Mathews JA, Kasahara DI, Wurmbrand AP, Shore SA. Regulation of IL-17A expression in mice following subacute ozone exposure. J Immunotoxicol. 2016 05; 13(3):428-38. PMID: 27043160.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Mitchel JA, Antoniak S, Lee JH, Kim SH, McGill M, Kasahara DI, Randell SH, Israel E, Shore SA, Mackman N, Park JA. IL-13 Augments Compressive Stress-Induced Tissue Factor Expression in Human Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2016 Apr; 54(4):524-31. PMID: 26407210.
    Citations: 1     Fields:    Translation:HumansCells
  12. Kasahara DI, Mathews JA, Park CY, Cho Y, Hunt G, Wurmbrand AP, Liao JK, Shore SA. ROCK insufficiency attenuates ozone-induced airway hyperresponsiveness in mice. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 01; 309(7):L736-46. PMID: 26276827.
    Citations: 7     Fields:    Translation:HumansAnimals
  13. Mathews JA, Kasahara DI, Ribeiro L, Wurmbrand AP, Ninin FM, Shore SA. ?d T Cells Are Required for M2 Macrophage Polarization and Resolution of Ozone-Induced Pulmonary Inflammation in Mice. PLoS One. 2015; 10(7):e0131236. PMID: 26135595.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Williams AS, Mathews JA, Kasahara DI, Wurmbrand AP, Chen L, Shore SA. Innate and ozone-induced airway hyperresponsiveness in obese mice: role of TNF-a. Am J Physiol Lung Cell Mol Physiol. 2015 Jun 01; 308(11):L1168-77. PMID: 25840999.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Kasahara DI, Ninin FM, Wurmbrand AP, Liao JK, Shore SA. Abrogation of airway hyperresponsiveness but not inflammation by rho kinase insufficiency. Clin Exp Allergy. 2015 Feb; 45(2):457-70. PMID: 25323425.
    Citations: 5     Fields:    Translation:AnimalsCells
  16. Mathews JA, Williams AS, Brand JD, Wurmbrand AP, Chen L, Ninin FM, Si H, Kasahara DI, Shore SA. ?d T cells are required for pulmonary IL-17A expression after ozone exposure in mice: role of TNFa. PLoS One. 2014; 9(5):e97707. PMID: 24823369.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Kasahara DI, Kim HY, Mathews JA, Verbout NG, Williams AS, Wurmbrand AP, Ninin FM, Neto FL, Benedito LA, Hug C, Umetsu DT, Shore SA. Pivotal role of IL-6 in the hyperinflammatory responses to subacute ozone in adiponectin-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 15; 306(6):L508-20. PMID: 24381131.
    Citations: 12     Fields:    Translation:AnimalsCells
  18. Spiess PC, Kasahara D, Habibovic A, Hristova M, Randall MJ, Poynter ME, van der Vliet A. Acrolein exposure suppresses antigen-induced pulmonary inflammation. Respir Res. 2013 Oct 16; 14:107. PMID: 24131734.
    Citations: 8     Fields:    Translation:AnimalsCells
  19. Kasahara DI, Williams AS, Benedito LA, Ranscht B, Kobzik L, Hug C, Shore SA. Role of the adiponectin binding protein, T-cadherin (cdh13), in pulmonary responses to subacute ozone. PLoS One. 2013; 8(6):e65829. PMID: 23755285.
    Citations: 9     Fields:    Translation:Animals
  20. Verbout NG, Benedito L, Williams AS, Kasahara DI, Wurmbrand AP, Si H, Halayko AJ, Hug C, Shore SA. Impact of adiponectin overexpression on allergic airways responses in mice. J Allergy (Cairo). 2013; 2013:349520. PMID: 23861690.
    Citations: 6     
  21. Kim HY, Chang YJ, Chuang YT, Lee HH, Kasahara DI, Martin T, Hsu JT, Savage PB, Shore SA, Freeman GJ, Dekruyff RH, Umetsu DT. T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death. J Allergy Clin Immunol. 2013 Aug; 132(2):414-25.e6. PMID: 23672783.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Park JA, Sharif AS, Shiomi T, Kobzik L, Kasahara DI, Tschumperlin DJ, Voynow J, Drazen JM. Human neutrophil elastase-mediated goblet cell metaplasia is attenuated in TACE-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2013 May 15; 304(10):L701-7. PMID: 23564510.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Williams AS, Mathews JA, Kasahara DI, Chen L, Wurmbrand AP, Si H, Shore SA. Augmented pulmonary responses to acute ozone exposure in obese mice: roles of TNFR2 and IL-13. Environ Health Perspect. 2013 May; 121(5):551-7. PMID: 23434795.
    Citations: 13     Fields:    Translation:Animals
  24. Williams AS, Kasahara DI, Verbout NG, Fedulov AV, Zhu M, Si H, Wurmbrand AP, Hug C, Ranscht B, Shore SA. Role of the adiponectin binding protein, T-cadherin (Cdh13), in allergic airways responses in mice. PLoS One. 2012; 7(7):e41088. PMID: 22815927.
    Citations: 18     Fields:    Translation:AnimalsCells
  25. Williams AS, Chen L, Kasahara DI, Si H, Wurmbrand AP, Shore SA. Obesity and airway responsiveness: role of TNFR2. Pulm Pharmacol Ther. 2013 Aug; 26(4):444-54. PMID: 22584291.
    Citations: 19     Fields:    Translation:AnimalsCells
  26. Kasahara DI, Kim HY, Williams AS, Verbout NG, Tran J, Si H, Wurmbrand AP, Jastrab J, Hug C, Umetsu DT, Shore SA. Pulmonary inflammation induced by subacute ozone is augmented in adiponectin-deficient mice: role of IL-17A. J Immunol. 2012 May 01; 188(9):4558-67. PMID: 22474022.
    Citations: 30     Fields:    Translation:AnimalsCells
  27. Hizume DC, Toledo AC, Moriya HT, Saraiva-Romanholo BM, Almeida FM, Arantes-Costa FM, Vieira RP, Dolhnikoff M, Kasahara DI, Martins MA. Cigarette smoke dissociates inflammation and lung remodeling in OVA-sensitized and challenged mice. Respir Physiol Neurobiol. 2012 Apr 30; 181(2):167-76. PMID: 22446562.
    Citations: 6     Fields:    Translation:AnimalsPHPublic Health
  28. Hristova M, Spiess PC, Kasahara DI, Randall MJ, Deng B, van der Vliet A. The tobacco smoke component, acrolein, suppresses innate macrophage responses by direct alkylation of c-Jun N-terminal kinase. Am J Respir Cell Mol Biol. 2012 Jan; 46(1):23-33. PMID: 21778411.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  29. Shore SA, Williams ES, Chen L, Benedito LA, Kasahara DI, Zhu M. Impact of aging on pulmonary responses to acute ozone exposure in mice: role of TNFR1. Inhal Toxicol. 2011 Dec; 23(14):878-88. PMID: 22066571.
    Citations: 10     Fields:    Translation:AnimalsCells
  30. Zhu M, Liu PY, Kasahara DI, Williams AS, Verbout NG, Halayko AJ, Fedulov A, Shoji T, Williams ES, Noma K, Shore SA, Liao JK. Role of Rho kinase isoforms in murine allergic airway responses. Eur Respir J. 2011 Oct; 38(4):841-50. PMID: 21565918.
    Citations: 13     Fields:    Translation:AnimalsCells
  31. Lanças T, Kasahara DI, Gross JL, Pires-Neto RC, Deheinzelin D, Mauad T, Negri EM, Dolhnikoff M. Cholinergic hyperresponsiveness of peripheral lung parenchyma in chronic obstructive pulmonary disease. Respiration. 2011; 82(2):177-84. PMID: 21576920.
    Citations: 3     Fields:    Translation:Humans
  32. Olson N, Kasahara DI, Hristova M, Bernstein R, Janssen-Heininger Y, van der Vliet A. Modulation of NF-?B and hypoxia-inducible factor--1 by S-nitrosoglutathione does not alter allergic airway inflammation in mice. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):813-23. PMID: 20693401.
    Citations: 10     Fields:    Translation:Animals
  33. Berntsen P, Park CY, Rothen-Rutishauser B, Tsuda A, Sager TM, Molina RM, Donaghey TC, Alencar AM, Kasahara DI, Ericsson T, Millet EJ, Swenson J, Tschumperlin DJ, Butler JP, Brain JD, Fredberg JJ, Gehr P, Zhou EH. Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells. J R Soc Interface. 2010 Jun 06; 7 Suppl 3:S331-40. PMID: 20356875.
    Citations: 12     Fields:    Translation:HumansCells
  34. Zhu M, Hug C, Kasahara DI, Johnston RA, Williams AS, Verbout NG, Si H, Jastrab J, Srivastava A, Williams ES, Ranscht B, Shore SA. Impact of adiponectin deficiency on pulmonary responses to acute ozone exposure in mice. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):487-97. PMID: 19915153.
    Citations: 24     Fields:    Translation:AnimalsPHPublic Health
  35. Shore SA, Lang JE, Kasahara DI, Lu FL, Verbout NG, Si H, Williams ES, Terry RD, Lee A, Johnston RA. Pulmonary responses to subacute ozone exposure in obese vs. lean mice. J Appl Physiol (1985). 2009 Nov; 107(5):1445-52. PMID: 19745193.
    Citations: 22     Fields:    Translation:AnimalsPHPublic Health
  36. Boots AW, Hristova M, Kasahara DI, Haenen GR, Bast A, van der Vliet A. ATP-mediated activation of the NADPH oxidase DUOX1 mediates airway epithelial responses to bacterial stimuli. J Biol Chem. 2009 Jun 26; 284(26):17858-67. PMID: 19386603.
    Citations: 40     Fields:    Translation:HumansCells
  37. Olson N, Greul AK, Hristova M, Bove PF, Kasahara DI, van der Vliet A. Nitric oxide and airway epithelial barrier function: regulation of tight junction proteins and epithelial permeability. Arch Biochem Biophys. 2009 Apr 15; 484(2):205-13. PMID: 19100237.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  38. Ruiz Schütz VC, Drewiacki T, Nakashima AS, Arantes-Costa FM, Prado CM, Kasahara DI, Leick-Maldonado EA, Martins MA, Tibério IF. Oral tolerance attenuates airway inflammation and remodeling in a model of chronic pulmonary allergic inflammation. Respir Physiol Neurobiol. 2009 Jan 01; 165(1):13-21. PMID: 18930843.
    Citations: 4     Fields:    Translation:AnimalsCells
  39. Ckless K, Lampert A, Reiss J, Kasahara D, Poynter ME, Irvin CG, Lundblad LK, Norton R, van der Vliet A, Janssen-Heininger YM. Inhibition of arginase activity enhances inflammation in mice with allergic airway disease, in association with increases in protein S-nitrosylation and tyrosine nitration. J Immunol. 2008 Sep 15; 181(6):4255-64. PMID: 18768883.
    Citations: 30     Fields:    Translation:AnimalsCells
  40. Mauad T, Rivero DH, de Oliveira RC, Lichtenfels AJ, Guimarães ET, de Andre PA, Kasahara DI, Bueno HM, Saldiva PH. Chronic exposure to ambient levels of urban particles affects mouse lung development. Am J Respir Crit Care Med. 2008 Oct 01; 178(7):721-8. PMID: 18596224.
    Citations: 24     Fields:    Translation:AnimalsPHPublic Health
  41. Kasahara DI, Poynter ME, Othman Z, Hemenway D, van der Vliet A. Acrolein inhalation suppresses lipopolysaccharide-induced inflammatory cytokine production but does not affect acute airways neutrophilia. J Immunol. 2008 Jul 01; 181(1):736-45. PMID: 18566440.
    Citations: 14     Fields:    Translation:AnimalsCells
  42. Nakashima AS, Prado CM, Lanças T, Ruiz VC, Kasahara DI, Leick-Maldonado EA, Dolhnikoff M, Martins MA, Tibério IF. Oral tolerance attenuates changes in in vitro lung tissue mechanics and extracellular matrix remodeling induced by chronic allergic inflammation in guinea pigs. J Appl Physiol (1985). 2008 Jun; 104(6):1778-85. PMID: 18388250.
    Citations: 7     Fields:    Translation:AnimalsCells
  43. Portela CP, Leick-Maldonado EA, Kasahara DI, Prado CM, Calvo-Tibério IF, Martins MA, Palermo-Neto J. Effects of stress and neuropeptides on airway responses in ovalbumin-sensitized rats. Neuroimmunomodulation. 2007; 14(2):105-11. PMID: 17785991.
    Citations: 1     Fields:    Translation:Animals
  44. Prado CM, Leick-Maldonado EA, Miyamoto L, Yano LM, Kasahara DI, Martins MA, Tibério IF. Capsaicin-sensitive nerves and neurokinins modulate non-neuronal nNOS expression in lung. Respir Physiol Neurobiol. 2008 Jan 01; 160(1):37-44. PMID: 17897889.
    Citations: 3     Fields:    Translation:AnimalsCells
  45. Hizume DC, Rivero DH, Kasahara DI, Leme AS, Arantes-Costa FM, Olivo CR, Sales P, Dolhnikoff M, Martins MA. Effects of positive end-expiratory pressure in an experimental model of acute myocardial infarct in wistar rats. Shock. 2007 May; 27(5):584-9. PMID: 17438466.
    Citations: 2     Fields:    Translation:Animals
  46. Lanças T, Kasahara DI, Prado CM, Tibério IF, Martins MA, Dolhnikoff M. Comparison of early and late responses to antigen of sensitized guinea pig parenchymal lung strips. J Appl Physiol (1985). 2006 May; 100(5):1610-6. PMID: 16410372.
    Citations: 12     Fields:    Translation:AnimalsCells
  47. Fló C, Lopes FD, Kasahara DI, Silva AC, Jesus RC, Rivero DH, Saldiva PH, Martins MA, Jacob-Filho W. Effects of exercise training on papain-induced pulmonary emphysema in Wistar rats. J Appl Physiol (1985). 2006 Jan; 100(1):281-5. PMID: 16141386.
    Citations: 6     Fields:    Translation:Animals
  48. Prado CM, Leick-Maldonado EA, Kasahara DI, Capelozzi VL, Martins MA, Tibério IF. Effects of acute and chronic nitric oxide inhibition in an experimental model of chronic pulmonary allergic inflammation in guinea pigs. Am J Physiol Lung Cell Mol Physiol. 2005 Oct; 289(4):L677-83. PMID: 15937069.
    Citations: 11     Fields:    Translation:AnimalsCells
  49. Kasahara DI, Perini A, Lopes FD, Arantes-Costa FM, Martins MA, Nunes MP. Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guinea pigs. Braz J Med Biol Res. 2005 May; 38(5):723-30. PMID: 15917953.
    Citations:    Fields:    Translation:Animals
  50. Prado CM, Leick-Maldonado EA, Arata V, Kasahara DI, Martins MA, Tibério IF. Neurokinins and inflammatory cell iNOS expression in guinea pigs with chronic allergic airway inflammation. Am J Physiol Lung Cell Mol Physiol. 2005 Apr; 288(4):L741-8. PMID: 15579630.
    Citations: 8     Fields:    Translation:AnimalsCells
  51. Medeiros N, Rivero DH, Kasahara DI, Saiki M, Godleski JJ, Koutrakis P, Capelozzi VL, Saldiva PH, Antonangelo L. Acute pulmonary and hematological effects of two types of particle surrogates are influenced by their elemental composition. Environ Res. 2004 May; 95(1):62-70. PMID: 15068931.
    Citations: 4     Fields:    Translation:Animals
  52. Bussamra MH, da Silva Filho LV, Kasahara DI, Cukier A, Rodrigues JC, Stelmach R. Educational program for smoke-induced respiratory diseases in Brazilian Amazon: assessing knowledge about asthma. J Asthma. 2004 Feb; 41(1):35-41. PMID: 15046376.
    Citations:    Fields:    Translation:Humans
  53. Leick-Maldonado EA, Kay FU, Leonhardt MC, Kasahara DI, Prado CM, Fernandes FT, Martins MA, Tibério IF. Comparison of glucocorticoid and cysteinyl leukotriene receptor antagonist treatments in an experimental model of chronic airway inflammation in guinea-pigs. Clin Exp Allergy. 2004 Jan; 34(1):145-52. PMID: 14720275.
    Citations: 9     Fields:    Translation:AnimalsCells
  54. Tibério IF, Leick-Maldonado EA, Miyahara L, Kasahara DI, Spilborghs GM, Martins MA, Saldiva PH. Effects of neurokinins on airway and alveolar eosinophil recruitment. Exp Lung Res. 2003 Apr-May; 29(3):165-77. PMID: 12637228.
    Citations: 3     Fields:    Translation:AnimalsCells
  55. Leme AS, Kasahara DI, Nunes MP, Martins MA, Vieira JE. Exhaled nitric oxide collected with two different mouthpieces: a study in asthmatic patients. Braz J Med Biol Res. 2002 Oct; 35(10):1133-7. PMID: 12424484.
    Citations: 2     Fields:    Translation:HumansCells
  56. Vieira JE, Cukier A, Stelmach R, Kasahara DI, Gannam S, Warth M. Comparison of knowledge on asthma: doctors completing internal medicine residency and doctors completing medical school. Sao Paulo Med J. 2001 May 03; 119(3):101-4. PMID: 11391451.
    Citations: 2     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.