Harvard Catalyst Profiles

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David K. Simon, Ph.D., M.D.

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Mentoring

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56NS107302 (SIMON, DAVID K.) May 1, 2019 - Apr 30, 2020
    NIH/NINDS
    Autophagy-Proteasome Cross-Talk in Parkinson's Pathogenesis
    Role: Principal Investigator
  2. R21NS094840 (SIMON, DAVID K.) Jul 1, 2017 - Jun 30, 2019
    NIH/NINDS
    Mitochondrial mechanisms and vulnerability to alpha-synuclein toxicity
    Role: Principal Investigator
  3. R01NS086352 (SIMON, DAVID K.) Apr 1, 2014 - Mar 31, 2019
    NIH/NINDS
    PGC-1alpha and Pitx3 as individual and combined targets for neuroprotection
    Role: Principal Investigator
  4. R21NS084710 (SCHWARZSCHILD, MICHAEL A) Jul 1, 2013 - Jun 30, 2015
    NIH/NINDS
    Role of urate in protecting mitochondrial function in the brain
    Role: Co-Principal Investigator
  5. R21NS079324 (SIMON, DAVID K.) Sep 25, 2012 - Aug 31, 2014
    NIH/NINDS
    Mechanisms of Protection in the Brain by Physical Exercise in Polg Mutator Mice
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kaafarani HMA, Khalifeh JM, Ramly EP, Simon D, Safa R, Khalil L, Raad R, Hoballah JJ. A Nationwide, Systematic, and Comprehensive Assessment of Surgical Capacity in Lebanon: Results of the Surgical Capacity in Areas With Refugees (SCAR) Study. Ann Surg. 2019 Jun; 269(6):1206-1214. PMID: 31082922.
    Citations:    
  2. Espay AJ, Vizcarra JA, Marsili L, Lang AE, Simon DK, Merola A, Josephs KA, Fasano A, Morgante F, Savica R, Greenamyre JT, Cambi F, Yamasaki TR, Tanner CM, Gan-Or Z, Litvan I, Mata IF, Zabetian CP, Brundin P, Fernandez HH, Standaert DG, Kauffman MA, Schwarzschild MA, Sardi SP, Sherer T, Perry G, Leverenz JB. Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases. Neurology. 2019 Feb 12; 92(7):329-337. PMID: 30745444.
    Citations:    
  3. Quansah E, Peelaerts W, Langston JW, Simon DK, Colca J, Brundin P. Targeting energy metabolism via the mitochondrial pyruvate carrier as a novel approach to attenuate neurodegeneration. Mol Neurodegener. 2018 05 24; 13(1):28. PMID: 29793507.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Kaafarani HMA, Khalifeh JM, Ramly EP, Simon D, Safa R, Khalil L, Raad R, Hoballah JJ. A Nationwide, Systematic, and Comprehensive Assessment of Surgical Capacity in Lebanon: Results of the Surgical Capacity in Areas With Refugees (SCAR) Study. Ann Surg. 2018 Jan 25. PMID: 29373369.
    Citations:    Fields:    
  5. Leehey M, Luo S, Sharma S, Wills AA, Bainbridge JL, Wong PS, Simon DK, Schneider J, Zhang Y, Pérez A, Dhall R, Christine CW, Singer C, Cambi F, Boyd JT. Association of metabolic syndrome and change in Unified Parkinson's Disease Rating Scale scores. Neurology. 2017 Oct 24; 89(17):1789-1794. PMID: 28972194.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  6. Mandel M, de Uña-Álvarez J, Simon DK, Betensky RA. Inverse probability weighted Cox regression for doubly truncated data. Biometrics. 2018 06; 74(2):481-487. PMID: 28886206.
    Citations:    Fields:    
  7. Simon DK, Matott JC, Espinosa J, Abraham NA. Mitochondrial DNA mutations in Parkinson's disease brain. Acta Neuropathol Commun. 2017 04 29; 5(1):33. PMID: 28454551.
    Citations:    Fields:    Translation:HumansCells
  8. Gibbons CH, Simon DK, Huang M, Tilley B, Aminoff MJ, Bainbridge JL, Brodsky M, Freeman R, Goudreau J, Hamill RW, Luo ST, Singer C, Videnovic A, Bodis-Wollner I, Wong PS. Autonomic and electrocardiographic findings in Parkinson's disease. Auton Neurosci. 2017 07; 205:93-98. PMID: 28506500.
    Citations:    Fields:    Translation:Humans
  9. Chou KL, Elm JJ, Wielinski CL, Simon DK, Aminoff MJ, Christine CW, Liang GS, Hauser RA, Sudarsky L, Umeh CC, Voss T, Juncos J, Fang JY, Boyd JT, Bodis-Wollner I, Mari Z, Morgan JC, Wills AM, Lee SL, Parashos SA. Factors associated with falling in early, treated Parkinson's disease: The NET-PD LS1 cohort. J Neurol Sci. 2017 Jun 15; 377:137-143. PMID: 28477684.
    Citations: 2     Fields:    Translation:Humans
  10. Espay AJ, Schwarzschild MA, Tanner CM, Fernandez HH, Simon DK, Leverenz JB, Merola A, Chen-Plotkin A, Brundin P, Kauffman MA, Erro R, Kieburtz K, Woo D, Macklin EA, Standaert DG, Lang AE. Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials. Mov Disord. 2017 03; 32(3):319-324. PMID: 28233927.
    Citations: 7     Fields:    Translation:Humans
  11. Simon DK, Wu C, Tilley BC, Lohmann K, Klein C, Payami H, Wills AM, Aminoff MJ, Bainbridge J, Dewey R, Hauser RA, Schaake S, Schneider JS, Sharma S, Singer C, Tanner CM, Truong D, Wei P, Wong PS, Yang T. Caffeine, creatine, GRIN2A and Parkinson's disease progression. J Neurol Sci. 2017 Apr 15; 375:355-359. PMID: 28320167.
    Citations: 3     Fields:    Translation:Humans
  12. McPhearson T, Parnell S, Simon D, Gaffney O, Elmqvist T, Bai X, Roberts D, Revi A. Scientists must have a say in the future of cities. Nature. 2016 10 13; 538(7624):165-166. PMID: 27734889.
    Citations: 2     Fields:    Translation:Humans
  13. Klein C, Löchte T, Delamonte SM, Braenne I, Hicks AA, Zschiedrich-Jansen K, Simon DK, Friedman JH, Lohmann K. PLA2G6 mutations and Parkinsonism: Long-term follow-up of clinical features and neuropathology. Mov Disord. 2016 12; 31(12):1927-1929. PMID: 27709683.
    Citations: 1     Fields:    Translation:Humans
  14. Brys M, Fox MD, Agarwal S, Biagioni M, Dacpano G, Kumar P, Pirraglia E, Chen R, Wu A, Fernandez H, Wagle Shukla A, Lou JS, Gray Z, Simon DK, Di Rocco A, Pascual-Leone A. Multifocal repetitive TMS for motor and mood symptoms of Parkinson disease: A randomized trial. Neurology. 2016 11 01; 87(18):1907-1915. PMID: 27708129.
    Citations: 10     Fields:    Translation:Humans
  15. Graebner AK, Tarsy D, Shih LC, Vanderhorst V, Kulkarni O, Kaplan S, Simon DK. Clinical Impact of 123I-Ioflupane SPECT (DaTscan) in a Movement Disorder Center. Neurodegener Dis. 2017; 17(1):38-43. PMID: 27614874.
    Citations:    Fields:    Translation:Humans
  16. Apetauerova D, Scala SA, Hamill RW, Simon DK, Pathak S, Ruthazer R, Standaert DG, Yacoubian TA. CoQ10 in progressive supranuclear palsy: A randomized, placebo-controlled, double-blind trial. Neurol Neuroimmunol Neuroinflamm. 2016 Oct; 3(5):e266. PMID: 27583276.
    Citations: 6     
  17. Roland ME, Barin B, Huprikar S, Murphy B, Hanto DW, Blumberg E, Olthoff K, Simon D, Hardy WD, Beatty G, Stock PG. Survival in HIV-positive transplant recipients compared with transplant candidates and with HIV-negative controls. AIDS. 2016 Jan 28; 30(3):435-44. PMID: 26765937.
    Citations: 5     Fields:    Translation:Humans
  18. Taylor KM, Saint-Hilaire MH, Sudarsky L, Simon DK, Hersh B, Sparrow D, Hu H, Weisskopf MG. Head injury at early ages is associated with risk of Parkinson's disease. Parkinsonism Relat Disord. 2016 Feb; 23:57-61. PMID: 26725141.
    Citations: 6     Fields:    Translation:Humans
  19. Stephen CD, Rojas R, Lioutas VA, Papavassiliou E, Simon DK. Complicated spontaneous intracranial hypotension treated with intrathecal saline infusion. Pract Neurol. 2016 Apr; 16(2):146-9. PMID: 26467251.
    Citations: 1     Fields:    Translation:Humans
  20. Simon DK, Wu C, Tilley BC, Wills AM, Aminoff MJ, Bainbridge J, Hauser RA, Schneider JS, Sharma S, Singer C, Tanner CM, Truong D, Wong PS. Caffeine and Progression of Parkinson Disease: A Deleterious Interaction With Creatine. Clin Neuropharmacol. 2015 Sep-Oct; 38(5):163-9. PMID: 26366971.
    Citations: 6     Fields:    Translation:HumansCTClinical Trials
  21. Clark-Matott J, Saleem A, Dai Y, Shurubor Y, Ma X, Safdar A, Beal MF, Tarnopolsky M, Simon DK. Metabolomic analysis of exercise effects in the POLG mitochondrial DNA mutator mouse brain. Neurobiol Aging. 2015 Nov; 36(11):2972-2983. PMID: 26294258.
    Citations: 4     Fields:    Translation:Animals
  22. Ebrahimian T, Simon D, Lemarié CA, Simeone S, Heidari M, Mann KK, Wassmann S, Lehoux S. Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE-/- Mice. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1190-7. PMID: 25767273.
    Citations: 1     Fields:    Translation:AnimalsCells
  23. Kieburtz K, Tilley BC, Elm JJ, Babcock D, Hauser R, Ross GW, Augustine AH, Augustine EU, Aminoff MJ, Bodis-Wollner IG, Boyd J, Cambi F, Chou K, Christine CW, Cines M, Dahodwala N, Derwent L, Dewey RB, Hawthorne K, Houghton DJ, Kamp C, Leehey M, Lew MF, Liang GS, Luo ST, Mari Z, Morgan JC, Parashos S, Pérez A, Petrovitch H, Rajan S, Reichwein S, Roth JT, Schneider JS, Shannon KM, Simon DK, Simuni T, Singer C, Sudarsky L, Tanner CM, Umeh CC, Williams K, Wills AM. Effect of creatine monohydrate on clinical progression in patients with Parkinson disease: a randomized clinical trial. JAMA. 2015 Feb 10; 313(6):584-93. PMID: 25668262.
    Citations: 41     Fields:    Translation:Humans
  24. Simon DK, Simuni T, Elm J, Clark-Matott J, Graebner AK, Baker L, Dunlop SR, Emborg M, Kamp C, Morgan JC, Ross GW, Sharma S, Ravina B. Peripheral Biomarkers of Parkinson's Disease Progression and Pioglitazone Effects. J Parkinsons Dis. 2015; 5(4):731-6. PMID: 26444095.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  25. Umeh CC, Pérez A, Augustine EF, Dhall R, Dewey RB, Mari Z, Simon DK, Wills AM, Christine CW, Schneider JS, Suchowersky O. No sex differences in use of dopaminergic medication in early Parkinson disease in the US and Canada - baseline findings of a multicenter trial. PLoS One. 2014; 9(12):e112287. PMID: 25486269.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  26. Dai Y, Clark J, Zheng K, Kujoth GC, Prolla TA, Simon DK. Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. Neurotoxicol Teratol. 2014 Nov-Dec; 46:62-7. PMID: 25450660.
    Citations: 3     Fields:    Translation:AnimalsCells
  27. Beal MF, Oakes D, Shoulson I, Henchcliffe C, Galpern WR, Haas R, Juncos JL, Nutt JG, Voss TS, Ravina B, Shults CM, Helles K, Snively V, Lew MF, Griebner B, Watts A, Gao S, Pourcher E, Bond L, Kompoliti K, Agarwal P, Sia C, Jog M, Cole L, Sultana M, Kurlan R, Richard I, Deeley C, Waters CH, Figueroa A, Arkun A, Brodsky M, Ondo WG, Hunter CB, Jimenez-Shahed J, Palao A, Miyasaki JM, So J, Tetrud J, Reys L, Smith K, Singer C, Blenke A, Russell DS, Cotto C, Friedman JH, Lannon M, Zhang L, Drasby E, Kumar R, Subramanian T, Ford DS, Grimes DA, Cote D, Conway J, Siderowf AD, Evatt ML, Sommerfeld B, Lieberman AN, Okun MS, Rodriguez RL, Merritt S, Swartz CL, Martin WR, King P, Stover N, Guthrie S, Watts RL, Ahmed A, Fernandez HH, Winters A, Mari Z, Dawson TM, Dunlop B, Feigin AS, Shannon B, Nirenberg MJ, Ogg M, Ellias SA, Thomas CA, Frei K, Bodis-Wollner I, Glazman S, Mayer T, Hauser RA, Pahwa R, Langhammer A, Ranawaya R, Derwent L, Sethi KD, Farrow B, Prakash R, Litvan I, Robinson A, Sahay A, Gartner M, Hinson VK, Markind S, Pelikan M, Perlmutter JS, Hartlein J, Molho E, Evans S, Adler CH, Duffy A, Lind M, Elmer L, Davis K, Spears J, Wilson S, Leehey MA, Hermanowicz N, Niswonger S, Shill HA, Obradov S, Rajput A, Cowper M, Lessig S, Song D, Fontaine D, Zadikoff C, Williams K, Blindauer KA, Bergholte J, Propsom CS, Stacy MA, Field J, Mihaila D, Chilton M, Uc EY, Sieren J, Simon DK, Kraics L, Silver A, Boyd JT, Hamill RW, Ingvoldstad C, Young J, Thomas K, Kostyk SK, Wojcieszek J, Pfeiffer RF, Panisset M, Beland M, Reich SG, Cines M, Zappala N, Rivest J, Zweig R, Lumina LP, Hilliard CL, Grill S, Kellermann M, Tuite P, Rolandelli S, Kang UJ, Young J, Rao J, Cook MM, Severt L, Boyar K. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014 May; 71(5):543-52. PMID: 24664227.
    Citations: 53     Fields:    Translation:HumansCTClinical Trials
  28. Austin MD, Simon DK, Betensky RA. Computationally simple estimation and improved efficiency for special cases of double truncation. Lifetime Data Anal. 2014 Jul; 20(3):335-54. PMID: 24347050.
    Citations: 2     Fields:    Translation:Humans
  29. Dai Y, Zheng K, Clark J, Swerdlow RH, Pulst SM, Sutton JP, Shinobu LA, Simon DK. Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation. Hum Mol Genet. 2014 Feb 01; 23(3):637-47. PMID: 24101601.
    Citations: 16     Fields:    Translation:HumansCells
  30. Shelley R, Kim NS, Parsons PJ, Lee BK, Agnew J, Jaar BG, Steuerwald AJ, Matanoski G, Fadrowski J, Schwartz BS, Todd AC, Simon D, Weaver VM. Uranium associations with kidney outcomes vary by urine concentration adjustment method. J Expo Sci Environ Epidemiol. 2014 Jan-Feb; 24(1):58-64. PMID: 23591699.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  31. Dai Y, Kiselak T, Clark J, Clore E, Zheng K, Cheng A, Kujoth GC, Prolla TA, Maratos-Flier E, Simon DK. Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice. Mitochondrion. 2013 Jul; 13(4):282-91. PMID: 23542163.
    Citations: 15     Fields:    Translation:AnimalsCells
  32. Demetrius LA, Simon DK. The inverse association of cancer and Alzheimer's: a bioenergetic mechanism. J R Soc Interface. 2013 May 06; 10(82):20130006. PMID: 23427097.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  33. Clark J, Silvaggi JM, Kiselak T, Zheng K, Clore EL, Dai Y, Bass CE, Simon DK. Pgc-1a overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. PLoS One. 2012; 7(11):e48925. PMID: 23145024.
    Citations: 21     Fields:    Translation:AnimalsCells
  34. Demetrius LA, Simon DK. An inverse-Warburg effect and the origin of Alzheimer's disease. Biogerontology. 2012 Dec; 13(6):583-94. PMID: 23086530.
    Citations: 14     Fields:    Translation:HumansCells
  35. Kumar KR, Weissbach A, Heldmann M, Kasten M, Tunc S, Sue CM, Svetel M, Kostic VS, Segura-Aguilar J, Ramirez A, Simon DK, Vieregge P, Münte TF, Hagenah J, Klein C, Lohmann K. Frequency of the D620N mutation in VPS35 in Parkinson disease. Arch Neurol. 2012 Oct; 69(10):1360-4. PMID: 22801713.
    Citations: 18     Fields:    Translation:Humans
  36. Simon DK, Chu CT, Swerdlow RH. Mitochondria and Parkinson's disease. Parkinsons Dis. 2011; 2011:261791. PMID: 22973533.
    Citations: 1     
  37. Göbel A, Macklin EA, Winkler S, Betensky RA, Klein C, Lohmann K, Simon DK. Genetic risk factors in Parkinson's disease: single gene effects and interactions of genotypes. J Neurol. 2012 Nov; 259(11):2503-5. PMID: 22878430.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  38. Lin MT, Cantuti-Castelvetri I, Zheng K, Jackson KE, Tan YB, Arzberger T, Lees AJ, Betensky RA, Beal MF, Simon DK. Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease. Ann Neurol. 2012 Jun; 71(6):850-4. PMID: 22718549.
    Citations: 20     Fields:    Translation:HumansCells
  39. Terrault NA, Roland ME, Schiano T, Dove L, Wong MT, Poordad F, Ragni MV, Barin B, Simon D, Olthoff KM, Johnson L, Stosor V, Jayaweera D, Fung J, Sherman KE, Subramanian A, Millis JM, Slakey D, Berg CL, Carlson L, Ferrell L, Stablein DM, Odim J, Fox L, Stock PG. Outcomes of liver transplant recipients with hepatitis C and human immunodeficiency virus coinfection. Liver Transpl. 2012 Jun; 18(6):716-26. PMID: 22328294.
    Citations: 50     Fields:    Translation:Humans
  40. Shih LC, Piel J, Warren A, Kraics L, Silver A, Vanderhorst V, Simon DK, Tarsy D. Singing in groups for Parkinson's disease (SING-PD): a pilot study of group singing therapy for PD-related voice/speech disorders. Parkinsonism Relat Disord. 2012 Jun; 18(5):548-52. PMID: 22436653.
    Citations: 2     Fields:    Translation:Humans
  41. Pankratz N, Beecham GW, DeStefano AL, Dawson TM, Doheny KF, Factor SA, Hamza TH, Hung AY, Hyman BT, Ivinson AJ, Krainc D, Latourelle JC, Clark LN, Marder K, Martin ER, Mayeux R, Ross OA, Scherzer CR, Simon DK, Tanner C, Vance JM, Wszolek ZK, Zabetian CP, Myers RH, Payami H, Scott WK, Foroud T. Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2. Ann Neurol. 2012 Mar; 71(3):370-84. PMID: 22451204.
    Citations: 80     Fields:    Translation:Humans
  42. Donovan S, Lim C, Rose P, Tarsy D, Sudarsky LR, Simon DK. The utility of laser-generated visual-cueing in Parkinsonian patients with gait freezing. Parkinsonism Relat Disord. 2012 May; 18(4):401. PMID: 21963184.
    Citations:    
  43. Clark J, Reddy S, Zheng K, Betensky RA, Simon DK. Association of PGC-1alpha polymorphisms with age of onset and risk of Parkinson's disease. BMC Med Genet. 2011 May 19; 12:69. PMID: 21595954.
    Citations: 27     Fields:    Translation:Humans
  44. Clark J, Dai Y, Simon DK. Do somatic mitochondrial DNA mutations contribute to Parkinson's disease? Parkinsons Dis. 2011; 2011:659694. PMID: 21603185.
    Citations: 7     
  45. Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello RC, Wszolek ZK, Uitti RJ, Van Gerpen JA, Simon DK, Tarsy D, Hedera P, Truong DD, Frei KP, Blitzer A, Rudzinska M, Pfeiffer RF, Le C, LeDoux MS. The c.-237_236GA>TT THAP1 sequence variant does not increase risk for primary dystonia. Mov Disord. 2011 Feb 15; 26(3):549-52. PMID: 21370264.
    Citations: 12     Fields:    Translation:HumansCells
  46. Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J, Davis C, Blumberg E, Simon D, Subramanian A, Millis JM, Lyon GM, Brayman K, Slakey D, Shapiro R, Melancon J, Jacobson JM, Stosor V, Olson JL, Stablein DM, Roland ME. Outcomes of kidney transplantation in HIV-infected recipients. N Engl J Med. 2010 Nov 18; 363(21):2004-14. PMID: 21083386.
    Citations: 83     Fields:    Translation:HumansCTClinical Trials
  47. Weisskopf MG, Weuve J, Nie H, Saint-Hilaire MH, Sudarsky L, Simon DK, Hersh B, Schwartz J, Wright RO, Hu H. Association of cumulative lead exposure with Parkinson's disease. Environ Health Perspect. 2010 Nov; 118(11):1609-13. PMID: 20807691.
    Citations: 25     Fields:    Translation:HumansPHPublic Health
  48. Weaver VM, Kim NS, Jaar BG, Schwartz BS, Parsons PJ, Steuerwald AJ, Todd AC, Simon D, Lee BK. Associations of low-level urine cadmium with kidney function in lead workers. Occup Environ Med. 2011 Apr; 68(4):250-6. PMID: 20974743.
    Citations: 13     Fields:    Translation:HumansPHPublic Health
  49. Connolly BS, Feigenbaum AS, Robinson BH, Dipchand AI, Simon DK, Tarnopolsky MA. MELAS syndrome, cardiomyopathy, rhabdomyolysis, and autism associated with the A3260G mitochondrial DNA mutation. Biochem Biophys Res Commun. 2010 Nov 12; 402(2):443-7. PMID: 20965148.
    Citations: 6     Fields:    Translation:Humans
  50. Clark J, Clore EL, Zheng K, Adame A, Masliah E, Simon DK. Oral N-acetyl-cysteine attenuates loss of dopaminergic terminals in alpha-synuclein overexpressing mice. PLoS One. 2010 Aug 23; 5(8):e12333. PMID: 20808797.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  51. Guo X, Kudryavtseva E, Bodyak N, Nicholas A, Dombrovsky I, Yang D, Kraytsberg Y, Simon DK, Khrapko K. Mitochondrial DNA deletions in mice in men: substantia nigra is much less affected in the mouse. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):1159-62. PMID: 20388490.
    Citations: 6     Fields:    Translation:HumansAnimals
  52. Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello R, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Van Gerpen JA, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, LeDoux MS. Novel human pathological mutations. Gene symbol: THAP1. Disease: dystonia 6. Hum Genet. 2010 Apr; 127(4):469. PMID: 21488277.
    Citations:    Fields:    Translation:HumansCells
  53. Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello R, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Van Gerpen JA, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, LeDoux MS. Novel human pathological mutations. Gene symbol: THAP1. Disease: dystonia 6. Hum Genet. 2010 Apr; 127(4):470. PMID: 21488252.
    Citations: 1     Fields:    Translation:HumansCells
  54. Simon DK, Pankratz N, Kissell DK, Pauciulo MW, Halter CA, Rudolph A, Pfeiffer RF, Nichols WC, Foroud T. Maternal inheritance and mitochondrial DNA variants in familial Parkinson's disease. BMC Med Genet. 2010 Apr 01; 11:53. PMID: 20356410.
    Citations: 13     Fields:    Translation:Humans
  55. Xiao J, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello R, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Van Gerpen JA, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, LeDoux MS. Novel human pathological mutations. Gene symbol: THAP1. Disease: dystonia 6. Hum Genet. 2010 Apr; 127(4):470. PMID: 21488298.
    Citations:    Fields:    Translation:HumansCells
  56. Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello R, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Van Gerpen JA, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, LeDoux MS. Novel human pathological mutations. Gene symbol: THAP1. Disease: dystonia 6. Hum Genet. 2010 Apr; 127(4):469-70. PMID: 21488296.
    Citations:    Fields:    Translation:HumansCells
  57. Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello R, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Van Gerpen JA, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, LeDoux MS. Novel human pathological mutations. Gene symbol: THAP1. Disease: dystonia 6. Hum Genet. 2010 Apr; 127(4):470. PMID: 21488297.
    Citations:    Fields:    Translation:HumansCells
  58. Xiao J, Zhao Y, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello RC, Wszolek ZK, Uitti RJ, Van Gerpen JA, Simon DK, Tarsy D, Hedera P, Truong DD, Frei KP, Dev Batish S, Blitzer A, Pfeiffer RF, Gong S, LeDoux MS. Novel THAP1 sequence variants in primary dystonia. Neurology. 2010 Jan 19; 74(3):229-38. PMID: 20083799.
    Citations: 40     Fields:    Translation:HumansCells
  59. Simon D, Coyle M, Dagenais S, O'Neil J, Wai EK. Potential triaging of referrals for lumbar spinal surgery consultation: a comparison of referral accuracy from pain specialists, findings from advanced imaging and a 3-item questionnaire. Can J Surg. 2009 Dec; 52(6):473-80. PMID: 20011183.
    Citations: 5     Fields:    Translation:Humans
  60. Sikorska M, Sandhu JK, Simon DK, Pathiraja V, Sodja C, Li Y, Ribecco-Lutkiewicz M, Lanthier P, Borowy-Borowski H, Upton A, Raha S, Pulst SM, Tarnopolsky MA. Identification of ataxia-associated mtDNA mutations (m.4052T>C and m.9035T>C) and evaluation of their pathogenicity in transmitochondrial cybrids. Muscle Nerve. 2009 Sep; 40(3):381-94. PMID: 19626676.
    Citations: 6     Fields:    Translation:HumansCells
  61. Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, Dodek P, Wood G, Kumar A, Simon D, Peters C, Ahsan M, Chateau D. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009 Nov; 136(5):1237-1248. PMID: 19696123.
    Citations: 201     Fields:    Translation:Humans
  62. Kraytsberg Y, Simon DK, Turnbull DM, Khrapko K. Do mtDNA deletions drive premature aging in mtDNA mutator mice? Aging Cell. 2009 Aug; 8(4):502-6. PMID: 19416127.
    Citations: 21     Fields:    Translation:Animals
  63. Xiao J, Bastian RW, Perlmutter JS, Racette BA, Tabbal SD, Karimi M, Paniello RC, Blitzer A, Batish SD, Wszolek ZK, Uitti RJ, Hedera P, Simon DK, Tarsy D, Truong DD, Frei KP, Pfeiffer RF, Gong S, Zhao Y, LeDoux MS. High-throughput mutational analysis of TOR1A in primary dystonia. BMC Med Genet. 2009 Mar 11; 10:24. PMID: 19284587.
    Citations: 18     Fields:    Translation:Humans
  64. Clark J, Simon DK. Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson's disease. Antioxid Redox Signal. 2009 Mar; 11(3):509-28. PMID: 18717631.
    Citations: 32     Fields:    Translation:HumansCells
  65. Simon, David K. Mitochondrial Encephalopathies. Encyclopedia of Movement Disorders. 2009.
  66. Simon, D.K. Parkinson's Disease. Textbook of Geriatrics and Gerontology, International. 2009; (In Press).
  67. Simon, David K. Complex I Deficiency in Parkinson's Disease. Encyclopedia of Movement Disorders. 2009.
  68. Tarsy D, Simon DK. Beating a dead horse: dopamine and Parkinson disease. Neurology. 2008 Nov 11; 71(20):1651; author reply 1651-2. PMID: 19001260.
    Citations: 1     Fields:    Translation:Humans
  69. Simon DK, Swearingen CJ, Hauser RA, Trugman JM, Aminoff MJ, Singer C, Truong D, Tilley BC. Caffeine and progression of Parkinson disease. Clin Neuropharmacol. 2008 Jul-Aug; 31(4):189-96. PMID: 18670242.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  70. Sunita Venkateswaran, Mary Sacchetti, Doug Arnold, Dessa Sadovnick, Julia Kennedy; Donald Gagne, Brenda Banwell, the Canadian Pediatric Demyelinating Study Group, Amit Bar-Or and David Simon. Mitochondrial mutations in pediatric clinically isolated demyelinating syndromes (CIS). American Academy of Neurology Annual Meeting (Chicago; 2008). 2008; In Press.
  71. MG Weisskopf, J Weuve, H Nie, M Saint-Hilaire, L Sudarsky, DK Simon, B Hersh, J Schwartz, RO Wright, R Feldman, and H Hu. . Cumulative exposure to lead and risk of Parkinson’s disease. . 2008 International Society for Environmental Epidemiology (ISEE) Annual Meeting. 2008.
  72. David K. Simon. PD Monitor & Commentary. 2008.
  73. Wu AD, Fregni F, Simon DK, Deblieck C, Pascual-Leone A. Noninvasive brain stimulation for Parkinson's disease and dystonia. Neurotherapeutics. 2008 Apr; 5(2):345-61. PMID: 18394576.
    Citations: 20     Fields:    Translation:Humans
  74. David K. Simon. Parkinson's Disease. Geriatrics Update. 2008.
  75. Lin MT, Cheng A, Zheng K, Atnip K, Kujoth G, Clark J., Arzberger T, Yang L, Betensky RA, Beal MF, Prolla TA, Standaert DG, Cantuti-Castelvetri I, Simon DK. . High Levels of Somatic Mitochondrial DNA Point Mutations in Early Parkinson’s Disease. American Neurological Association Annual Meeting (Washington D.C.). 2007.
  76. Djarmati A, Guzvic M, Grünewald A, Lang AE, Pramstaller PP, Simon DK, Kaindl AM, Vieregge P, Nygren AO, Beetz C, Hedrich K, Klein C. Rapid and reliable detection of exon rearrangements in various movement disorders genes by multiplex ligation-dependent probe amplification. Mov Disord. 2007 Sep 15; 22(12):1708-14. PMID: 17674414.
    Citations: 7     Fields:    Translation:Humans
  77. Simon DK, Zheng K, Velázquez L, Santos N, Almaguer L, Figueroa KP, Pulst SM. Mitochondrial complex I gene variant associated with early age at onset in spinocerebellar ataxia type 2. Arch Neurol. 2007 Jul; 64(7):1042-4. PMID: 17620498.
    Citations: 10     Fields:    Translation:HumansCells
  78. Lin MT, Cheng A, Zheng K, Atnip K, Kujoth G, Arzberger T, Yang L, Beal MF, Prolla TA, Standaert DG, Cantuti-Castelvetri I, Simon DK. . Somatic Mitochondrial DNA Point Mutations in Dopaminergic Neurons. American Academy of Neurology Annual Meeting (Boston). 2007.
  79. Joanne Clark DPhil; Michael A. Nili, PhD; Kangni Zheng MD; Shyan-Yuan Kao, PhD; Bruce A. Yankner, MD PhD; Glenn L. Wilson PhD; David K. Simon MD PhD. Rescue of alpha-synuclein induced glutathione depletion by n-acetylcysteine. American Academy of Neurology Annual Meeting (Boston). 2007.
  80. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006 Oct 20; 127(2):397-408. PMID: 17055439.
    Citations: 647     Fields:    Translation:HumansAnimalsCells
  81. Tarsy D, Simon DK. Dystonia. N Engl J Med. 2006 Aug 24; 355(8):818-29. PMID: 16928997.
    Citations: 52     Fields:    Translation:Humans
  82. Simon D, Finn L, Eddy A. Subepithelial humps and microthrombi: looking for a mechanism. Am J Kidney Dis. 2006 Feb; 47(2):365-70. PMID: 16431268.
    Citations:    
  83. Fregni F, Simon DK, Wu A, Pascual-Leone A. Non-invasive brain stimulation for Parkinson's disease: a systematic review and meta-analysis of the literature. J Neurol Neurosurg Psychiatry. 2005 Dec; 76(12):1614-23. PMID: 16291882.
    Citations: 51     Fields:    Translation:Humans
  84. Lee J, Kim CH, Simon DK, Aminova LR, Andreyev AY, Kushnareva YE, Murphy AN, Lonze BE, Kim KS, Ginty DD, Ferrante RJ, Ryu H, Ratan RR. Mitochondrial cyclic AMP response element-binding protein (CREB) mediates mitochondrial gene expression and neuronal survival. J Biol Chem. 2005 Dec 09; 280(49):40398-401. PMID: 16207717.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  85. Lin MT, Simon DK. No evidence for heritability of Parkinson disease in Swedish twins. Neurology. 2005 Mar 08; 64(5):932; author reply 932. PMID: 15753453.
    Citations: 1     Fields:    Translation:Humans
  86. Cantuti-Castelvetri I, Lin MT, Zheng K, Keller-McGandy CE, Betensky RA, Johns DR, Beal MF, Standaert DG, Simon DK. Somatic mitochondrial DNA mutations in single neurons and glia. Neurobiol Aging. 2005 Nov-Dec; 26(10):1343-55. PMID: 16243605.
    Citations: 28     Fields:    Translation:HumansCells
  87. Simon DK, Nishino S, Scammell TE. Mistaken diagnosis of psychogenic gait disorder in a man with status cataplecticus ("limp man syndrome"). Mov Disord. 2004 Jul; 19(7):838-840. PMID: 15254948.
    Citations: 5     Fields:    Translation:Humans
  88. Nichols WC, Uniacke SK, Pankratz N, Reed T, Simon DK, Halter C, Rudolph A, Shults CW, Conneally PM, Foroud T. Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. Mov Disord. 2004 Jun; 19(6):649-55. PMID: 15197702.
    Citations: 10     Fields:    Translation:HumansCells
  89. Tarnopolsky MA, Simon DK, Roy BD, Chorneyko K, Lowther SA, Johns DR, Sandhu JK, Li Y, Sikorska M. Attenuation of free radical production and paracrystalline inclusions by creatine supplementation in a patient with a novel cytochrome b mutation. Muscle Nerve. 2004 Apr; 29(4):537-47. PMID: 15052619.
    Citations: 10     Fields:    Translation:HumansCells
  90. Tarnopolsky MA, Bourgeois JM, Fu MH, Kataeva G, Shah J, Simon DK, Mahoney D, Johns D, MacKay N, Robinson BH. Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype. Am J Med Genet A. 2004 Mar 15; 125A(3):310-4. PMID: 14994243.
    Citations: 8     Fields:    Translation:Humans
  91. Simon DK, Lin MT, Zheng L, Liu GJ, Ahn CH, Kim LM, Mauck WM, Twu F, Beal MF, Johns DR. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiol Aging. 2004 Jan; 25(1):71-81. PMID: 14675733.
    Citations: 33     Fields:    Translation:HumansCells
  92. Malouin R, Winch P, Leontsini E, Glass G, Simon D, Hayes EB, Schwartz BS. Longitudinal evaluation of an educational intervention for preventing tick bites in an area with endemic lyme disease in Baltimore County, Maryland. Am J Epidemiol. 2003 Jun 01; 157(11):1039-51. PMID: 12777368.
    Citations: 12     Fields:    Translation:HumansAnimalsPHPublic HealthCTClinical Trials
  93. Simon DK, Friedman J, Breakefield XO, Jankovic J, Brin MF, Provias J, Bressman SB, Charness ME, Tarsy D, Johns DR, Tarnopolsky MA. A heteroplasmic mitochondrial complex I gene mutation in adult-onset dystonia. Neurogenetics. 2003 Aug; 4(4):199-205. PMID: 12756609.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  94. Zheng K, Heydari B, Simon DK. A common NURR1 polymorphism associated with Parkinson disease and diffuse Lewy body disease. Arch Neurol. 2003 May; 60(5):722-5. PMID: 12756136.
    Citations: 20     Fields:    Translation:Humans
  95. Simon, DK. Mitochondrial Encephalopathy, Lactic Acidosis and Stroke (MELAS). Encyclopedia of the Neurological Sciences; Eds: MJ Aminoff and RB Daroff. 2003.
  96. Simon, David K. Mitochondrial Mutations in Parkinson's Disease and Dystonias. Genetics of Movement Disorders; Ed: Stephan M. Pulst. 2003; 474 - 490.
  97. Simon DK, Lin MT, Pascual-Leone A. "Nature versus nurture" and incompletely penetrant mutations. J Neurol Neurosurg Psychiatry. 2002 Jun; 72(6):686-9. PMID: 12023405.
    Citations: 3     Fields:    Translation:Humans
  98. Stewart WF, Schwartz BS, Simon D, Kelsey K, Todd AC. ApoE genotype, past adult lead exposure, and neurobehavioral function. Environ Health Perspect. 2002 May; 110(5):501-5. PMID: 12003753.
    Citations: 31     Fields:    Translation:HumansPHPublic Health
  99. Anschel DJ, Simon DK, Llinas R, Joseph JT. Spongiform encephalopathy mimicking corticobasal degeneration. Mov Disord. 2002 May; 17(3):606-7. PMID: 12112217.
    Citations: 2     Fields:    Translation:Humans
  100. Lin MT, Simon DK, Ahn CH, Kim LM, Beal MF. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain. Hum Mol Genet. 2002 Jan 15; 11(2):133-45. PMID: 11809722.
    Citations: 83     Fields:    Translation:Humans
  101. Simon DK, Lin MT, Ahn CH, Liu GJ, Gibson GE, Beal MF, Johns DR. Low mutational burden of individual acquired mitochondrial DNA mutations in brain. Genomics. 2001 Apr 01; 73(1):113-6. PMID: 11352572.
    Citations: 8     Fields:    Translation:HumansCells
  102. Simon DK, Tarnopolsky MA, Greenamyre JT, Johns DR. A frameshift mitochondrial complex I gene mutation in a patient with dystonia and cataracts: is the mutation pathogenic? J Med Genet. 2001 Jan; 38(1):58-61. PMID: 11332403.
    Citations: 4     Fields:    Translation:HumansCells
  103. Simon DK, Beal MF. Pathogenesis: Oxidative Stress, Mitochondria Dysfunction and Excitotoxicity. Dis.: Dx and Clinical Management;Ch 27; Eds: SA Factor WJ Weiner. 2001.
  104. Tabamo RE, Fernandez HH, Friedman JH, Simon DK. Young-onset Parkinson's disease: a clinical pathologic description of two siblings. Mov Disord. 2000 Jul; 15(4):744-6. PMID: 10928592.
    Citations:    Fields:    Translation:HumansCells
  105. Simon DK, Mayeux R, Marder K, Kowall NW, Beal MF, Johns DR. Mitochondrial DNA mutations in complex I and tRNA genes in Parkinson's disease. Neurology. 2000 Feb 08; 54(3):703-9. PMID: 10680807.
    Citations: 22     Fields:    Translation:Humans
  106. Simon DK, Pulst SM, Sutton JP, Browne SE, Beal MF, Johns DR. Familial multisystem degeneration with parkinsonism associated with the 11778 mitochondrial DNA mutation. Neurology. 1999 Nov 10; 53(8):1787-93. PMID: 10563629.
    Citations: 28     Fields:    Translation:HumansCells
  107. Simon DK. Parkinson disease in twins. JAMA. 1999 Oct 13; 282(14):1328; author reply 1328-9. PMID: 10527170.
    Citations:    Fields:    Translation:Humans
  108. Simon DK, Standaert DG. Neuroprotective therapies. Med Clin North Am. 1999 Mar; 83(2):509-23, viii. PMID: 10093591.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  109. Simon DK, Johns DR. Mitochondrial disorders: clinical and genetic features. Annu Rev Med. 1999; 50:111-27. PMID: 10073267.
    Citations: 24     Fields:    Translation:HumansCells
  110. Simon DK, Rodriguez ML, Frosch MP, Quackenbush EJ, Feske SK, Natowicz MR. A unique familial leukodystrophy with adult onset dementia and abnormal glycolipid storage: a new lysosomal disease? J Neurol Neurosurg Psychiatry. 1998 Aug; 65(2):251-4. PMID: 9703182.
    Citations: 1     Fields:    Translation:HumansCells
  111. Wen PY, Alyea EP, Simon D, Herbst RS, Soiffer RJ, Antin JH. Guillain-Barré syndrome following allogeneic bone marrow transplantation. Neurology. 1997 Dec; 49(6):1711-4. PMID: 9409375.
    Citations: 9     Fields:    Translation:Humans
  112. Simon DK, Roskies AL, O'Leary DD. Plasticity in the development of topographic order in the mammalian retinocollicular projection. Dev Biol. 1994 Apr; 162(2):384-93. PMID: 8150202.
    Citations: 7     Fields:    Translation:AnimalsCells
  113. Simon DK, Prusky GT, O'Leary DD, Constantine-Paton M. N-methyl-D-aspartate receptor antagonists disrupt the formation of a mammalian neural map. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10593-7. PMID: 1359542.
    Citations: 35     Fields:    Translation:AnimalsCells
  114. Simon DK, O'Leary DD. Responses of retinal axons in vivo and in vitro to position-encoding molecules in the embryonic superior colliculus. Neuron. 1992 Nov; 9(5):977-89. PMID: 1419004.
    Citations: 5     Fields:    Translation:AnimalsCells
  115. Simon DK, O'Leary DD. Influence of position along the medial-lateral axis of the superior colliculus on the topographic targeting and survival of retinal axons. Brain Res Dev Brain Res. 1992 Oct 23; 69(2):167-72. PMID: 1385014.
    Citations: 7     Fields:    Translation:AnimalsCells
  116. Simon DK, O'Leary DD. Development of topographic order in the mammalian retinocollicular projection. J Neurosci. 1992 Apr; 12(4):1212-32. PMID: 1313491.
    Citations: 59     Fields:    Translation:AnimalsCells
  117. Simon DK, O'Leary DD. Relationship of retinotopic ordering of axons in the optic pathway to the formation of visual maps in central targets. J Comp Neurol. 1991 May 15; 307(3):393-404. PMID: 1856329.
    Citations: 9     Fields:    Translation:AnimalsCells
  118. Simon DK, O'Leary DD. Limited topographic specificity in the targeting and branching of mammalian retinal axons. Dev Biol. 1990 Jan; 137(1):125-34. PMID: 1688537.
    Citations: 11     Fields:    Translation:AnimalsCells
  119. Shapiro ML, Simon DK, Olton DS, Gage FH, Nilsson O, Björklund A. Intrahippocampal grafts of fetal basal forebrain tissue alter place fields in the hippocampus of rats with fimbria-fornix lesions. Neuroscience. 1989; 32(1):1-18. PMID: 2586743.
    Citations: 12     Fields:    Translation:Animals
  120. Kleitman N, Simon DK, Schachner M, Bunge RP. Growth of embryonic retinal neurites elicited by contact with Schwann cell surfaces is blocked by antibodies to L1. Exp Neurol. 1988 Dec; 102(3):298-306. PMID: 2461864.
    Citations: 6     Fields:    Translation:AnimalsCells
  121. Shapiro ML, Simon D, Olton DS, Gage FH, Bjorklund A, Stenevi U. Brain transplants: can they restore single unit activity in the hippocampus? Ann N Y Acad Sci. 1985; 444:536-7. PMID: 3860121.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.