Harvard Catalyst Profiles

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Hakho Lee, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA233360 (LEE, HAKHO) Sep 1, 2018 - Jul 31, 2023
    NIH/NCI
    Early Detection through Novel OCEAN Technology - Ovarian Cancer Exosomal Analysis with Nanoplasmonics
    Role: Principal Investigator
  2. R01CA229777 (LEE, HAKHO) Aug 2, 2018 - Jul 31, 2023
    NIH/NCI
    Clinical platform for high-throughput analyses of extracellular vesicles
    Role: Principal Investigator
  3. R21CA205322 (LEE, HAKHO) May 1, 2016 - Apr 30, 2018
    NIH/NCI
    Multiplexed exosome analyses with DNA barcoding
    Role: Principal Investigator
  4. R01HL113156 (LEE, HAKHO) Apr 16, 2012 - Mar 31, 2017
    NIH/NHLBI
    MAGNETIC NANOSENSORS FOR BIOMEDICAL ANALYSES OF MICROVESICLES
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H. Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017 11 21; 17(23):4000-4007. PMID: 29067383.
    Citations:    Fields:    Translation:HumansCells
  2. Im H, Lee K, Weissleder R, Lee H, Castro CM. Novel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017 08 22; 17(17):2892-2898. PMID: 28745363.
    Citations: 2     Fields:    Translation:HumansCells
  3. Hong S, Park KS, Weissleder R, Castro CM, Lee H. Facile silicification of plastic surface for bioassays. Chem Commun (Camb). 2017 Feb 09; 53(13):2134-2137. PMID: 28134385.
    Citations:    Fields:    Translation:HumansCells
  4. Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H. Digital diffraction detection of protein markers for avian influenza. Lab Chip. 2016 Apr 21; 16(8):1340-5. PMID: 26980325.
    Citations:    Fields:    Translation:AnimalsCells
  5. Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H. Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab Chip. 2014 Jan 07; 14(1):14-23. PMID: 23835814.
    Citations: 9     Fields:    Translation:HumansCells
  6. Shao H, Chung J, Balaj L, Charest A, Bigner DD, Carter BS, Hochberg FH, Breakefield XO, Weissleder R, Lee H. Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat Med. 2012 Dec; 18(12):1835-40. PMID: 23142818.
    Citations: 141     Fields:    Translation:HumansCells
  7. Agasti SS, Liong M, Peterson VM, Lee H, Weissleder R. Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cells. J Am Chem Soc. 2012 Nov 14; 134(45):18499-502. PMID: 23092113.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  8. Agasti SS, Kohler RH, Liong M, Peterson VM, Lee H, Weissleder R. Dual imaging and photoactivated nanoprobe for controlled cell tracking. Small. 2013 Jan 28; 9(2):222-7. PMID: 22996932.
    Citations: 4     Fields:    
  9. Min C, Shao H, Liong M, Yoon TJ, Weissleder R, Lee H. Mechanism of magnetic relaxation switching sensing. ACS Nano. 2012 Aug 28; 6(8):6821-8. PMID: 22762250.
    Citations: 9     Fields:    
  10. Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H. Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med. 2012 Jul 04; 4(141):141ra92. PMID: 22764208.
    Citations: 58     Fields:    Translation:HumansCells
  11. Budin G, Chung HJ, Lee H, Weissleder R. A magnetic Gram stain for bacterial detection. Angew Chem Int Ed Engl. 2012 Jul 27; 51(31):7752-5. PMID: 22744868.
    Citations: 8     Fields:    Translation:Cells
  12. Chung J, Shao H, Reiner T, Issadore D, Weissleder R, Lee H. Microfluidic cell sorter (µFCS) for on-chip capture and analysis of single cells. Adv Healthc Mater. 2012 Jul; 1(4):432-6. PMID: 23184773.
    Citations: 10     Fields:    Translation:HumansCells
  13. Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder R. Sensitive and direct detection of circulating tumor cells by multimarker µ-nuclear magnetic resonance. Neoplasia. 2012 May; 14(5):388-95. PMID: 22745585.
    Citations: 16     Fields:    Translation:HumansCells
  14. Peterson VM, Castro CM, Lee H, Weissleder R. Orthogonal amplification of nanoparticles for improved diagnostic sensing. ACS Nano. 2012 Apr 24; 6(4):3506-13. PMID: 22424443.
    Citations: 5     Fields:    Translation:HumansCells
  15. Shao H, Min C, Issadore D, Liong M, Yoon TJ, Weissleder R, Lee H. Magnetic Nanoparticles and microNMR for Diagnostic Applications. Theranostics. 2012; 2(1):55-65. PMID: 22272219.
    Citations: 28     Fields:    
  16. Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R. Supramolecular host-guest interaction for labeling and detection of cellular biomarkers. Angew Chem Int Ed Engl. 2012 Jan 09; 51(2):450-4. PMID: 22113923.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  17. Liong M, Fernandez-Suarez M, Issadore D, Min C, Tassa C, Reiner T, Fortune SM, Toner M, Lee H, Weissleder R. Specific pathogen detection using bioorthogonal chemistry and diagnostic magnetic resonance. Bioconjug Chem. 2011 Dec 21; 22(12):2390-4. PMID: 22043803.
    Citations: 12     Fields:    Translation:HumansCells
  18. Ullal AV, Reiner T, Yang KS, Gorbatov R, Min C, Issadore D, Lee H, Weissleder R. Nanoparticle-mediated measurement of target-drug binding in cancer cells. ACS Nano. 2011 Nov 22; 5(11):9216-24. PMID: 21962084.
    Citations: 3     Fields:    Translation:HumansCells
  19. Chung HJ, Reiner T, Budin G, Min C, Liong M, Issadore D, Lee H, Weissleder R. Ubiquitous detection of gram-positive bacteria with bioorthogonal magnetofluorescent nanoparticles. ACS Nano. 2011 Nov 22; 5(11):8834-41. PMID: 21967150.
    Citations: 19     Fields:    Translation:AnimalsCells
  20. Yoon TJ, Lee H, Shao H, Hilderbrand SA, Weissleder R. Multicore assemblies potentiate magnetic properties of biomagnetic nanoparticles. Adv Mater. 2011 Nov 02; 23(41):4793-7. PMID: 21953810.
    Citations: 19     Fields:    Translation:HumansCells
  21. Liong M, Tassa C, Shaw SY, Lee H, Weissleder R. Multiplexed magnetic labeling amplification using oligonucleotide hybridization. Adv Mater. 2011 Sep 22; 23(36):H254-7. PMID: 21780311.
    Citations: 8     Fields:    Translation:HumansCells
  22. Issadore D, Min C, Liong M, Chung J, Weissleder R, Lee H. Miniature magnetic resonance system for point-of-care diagnostics. Lab Chip. 2011 Jul 07; 11(13):2282-7. PMID: 21547317.
    Citations: 31     Fields:    Translation:Cells
  23. Yoon TJ, Lee H, Shao H, Weissleder R. Highly magnetic core-shell nanoparticles with a unique magnetization mechanism. Angew Chem Int Ed Engl. 2011 May 09; 50(20):4663-6. PMID: 21495138.
    Citations: 20     Fields:    
  24. Haun JB, Devaraj NK, Marinelli BS, Lee H, Weissleder R. Probing intracellular biomarkers and mediators of cell activation using nanosensors and bioorthogonal chemistry. ACS Nano. 2011 Apr 26; 5(4):3204-13. PMID: 21351804.
    Citations: 15     Fields:    Translation:HumansCells
  25. Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med. 2011 Feb 23; 3(71):71ra16. PMID: 21346169.
    Citations: 58     Fields:    Translation:Humans
  26. Haun JB, Yoon TJ, Lee H, Weissleder R. Molecular detection of biomarkers and cells using magnetic nanoparticles and diagnostic magnetic resonance. Methods Mol Biol. 2011; 726:33-49. PMID: 21424441.
    Citations: 7     Fields:    Translation:Cells
  27. Liong M, Shao H, Haun JB, Lee H, Weissleder R. Carboxymethylated polyvinyl alcohol stabilizes doped ferrofluids for biological applications. Adv Mater. 2010 Dec 01; 22(45):5168-72. PMID: 20859943.
    Citations: 9     Fields:    Translation:HumansCells
  28. Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H. Self-assembled magnetic filter for highly efficient immunomagnetic separation. Lab Chip. 2011 Jan 07; 11(1):147-51. PMID: 20949198.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  29. Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R. Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection. Nat Nanotechnol. 2010 Sep; 5(9):660-5. PMID: 20676091.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  30. Haun JB, Yoon TJ, Lee H, Weissleder R. Magnetic nanoparticle biosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010 May-Jun; 2(3):291-304. PMID: 20336708.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  31. Lee H, Yoon TJ, Figueiredo JL, Swirski FK, Weissleder R. Rapid detection and profiling of cancer cells in fine-needle aspirates. Proc Natl Acad Sci U S A. 2009 Jul 28; 106(30):12459-64. PMID: 19620715.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  32. Wildgruber M, Lee H, Chudnovskiy A, Yoon TJ, Etzrodt M, Pittet MJ, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski FK. Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS One. 2009 May 22; 4(5):e5663. PMID: 19461894.
    Citations: 24     Fields:    Translation:HumansCells
  33. Lee H, Yoon TJ, Weissleder R. Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system. Angew Chem Int Ed Engl. 2009; 48(31):5657-60. PMID: 19554581.
    Citations: 29     Fields:    Translation:Cells
  34. Lee H, Sun E, Ham D, Weissleder R. Chip-NMR biosensor for detection and molecular analysis of cells. Nat Med. 2008 Aug; 14(8):869-74. PMID: 18607350.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  35. Insin N, Tracy JB, Lee H, Zimmer JP, Westervelt RM, Bawendi MG. Incorporation of iron oxide nanoparticles and quantum dots into silica microspheres. ACS Nano. 2008 Feb; 2(2):197-202. PMID: 19206619.
    Citations: 30     Fields:    Translation:Cells
  36. Lee H, Liu Y, Ham D, Westervelt RM. Integrated cell manipulation system--CMOS/microfluidic hybrid. Lab Chip. 2007 Mar; 7(3):331-7. PMID: 17330164.
    Citations: 11     Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.