Yvonne Claire Lee, M.D.
|Title||Assistant Professor of Medicine|
|Institution||Brigham and Women's Hospital|
|Address||Brigham and Womens Hospital|
75 Francis St
Boston MA 02115
(login for email)
My research focuses on the inflammatory and non-inflammatory components of pain in the rheumatic diseases. Pain is the most common reason patients seek rheumatologic care. However, little is known about the mechanisms of pain in rheumatic diseases, and the best ways to treat pain are still unknown.
To examine the components of pain among patients with rheumatic disease, we supplement data from validated instruments of clinical pain severity with quantitative sensory testing methods to assess experimental pain sensitivity. Using different testing paradigms, we are able to examine the contributions of peripheral mechanisms (e.g., inflammation and damage at joint sites) and central mechanisms (e.g., modulation of pain by the brain and spinal cord) to overall pain sensitivity.
Current research activities include a study to examine differences in central pain processing among rheumatoid arthritis (RA) patients compared to healthy controls and a clinical trial of milnacipran, a serotonin norepinephrine reuptake inhibitor, in the treatment of pain in RA. We also collaborate with prospective observational cohorts, such as the Brigham Rheumatoid Arthritis Sequential Study, to examine relationships between pain and inflammation in large rheumatic disease populations. We are particularly interested in examining the acute to chronic pain transition and defining clinical predictors of chronic pain.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
R01AR064850 (LEE, YVONNE CLAIRE)Jul 1, 2013 - Jun 30, 2018NIH/NIAMS
Central Pain Mechanisms, Pain Intensity and Drug Response in Rheumatoid Arthritis
Role: Principal Investigator
K23AR057578 (LEE, YVONNE CLAIRE)Sep 30, 2009 - Aug 31, 2014NIH/NIAMS
Mechanisms, Outcomes and Treatment of Non-Articular Pain in Rheumatoid Arthritis
Role: Principal Investigator
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Click the "See All" links for more information and interactive visualizations!
People who are also in this person's primary department.