David James Gregory, Ph.D.
Instructor in Pediatrics
Massachusetts General Hospital
Harvard School of Public Health
651 Huntington Ave
Boston MA 02115
My research focuses on the innate immune response to infection. I use computational and in vitro assays to identify regulatory genes that determine the outcome of infection, and present opportunities for therapeutic intervention. I developed a computational tool that enabled identification of a miRNA that protects against infection with intracellular bacteria. I have used RNAi screening to identify a cellular hub that may co-ordinate inflammatory gene expression, autophagy, and inflammatory cell death. I have also shown how a eukaryotic parasite distorts host transcription factor signaling using molecular approaches.
Much my work at Harvard has focused on developing countermeasures to potential biological weapons bacteria: Bacillus anthracis (anthrax), Yesinia pestis (plague), and especially Francisella tularensis (rabbit fever). I retain an interest in neglected, tropical parasites such as Leishmania. My current research focuses on using comparative bioinformatics to answer why different species differ greatly in their susceptibility to sepsis.
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