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David James Gregory, Ph.D.

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My research focuses on the innate immune response to infection. I use computational and in vitro assays to identify regulatory genes that determine the outcome of infection, and present opportunities for therapeutic intervention. I developed a computational tool that enabled identification of a miRNA that protects against infection with intracellular bacteria. I have used RNAi screening to identify a cellular hub that may co-ordinate inflammatory gene expression, autophagy, and inflammatory cell death. I have also shown how a eukaryotic parasite distorts host transcription factor signaling using molecular approaches.

Much my work at Harvard has focused on developing countermeasures to potential biological weapons bacteria: Bacillus anthracis (anthrax), Yesinia pestis (plague), and especially Francisella tularensis (rabbit fever). I retain an interest in neglected, tropical parasites such as Leishmania. My current research focuses on using comparative bioinformatics to answer why different species differ greatly in their susceptibility to sepsis.

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Garcia-Beltran WF, Lam EC, St Denis K, Nitido AD, Garcia ZH, Hauser BM, Feldman J, Pavlovic MN, Gregory DJ, Poznansky MC, Sigal A, Schmidt AG, Iafrate AJ, Naranbhai V, Balazs AB. Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity. Cell. 2021 04 29; 184(9):2372-2383.e9. PMID: 33743213.
    Citations: 22     Fields:    
  2. Gregory DJ, DeLoid GM, Salmon SL, Metzger DW, Kramnik I, Kobzik L. SON DNA-binding protein mediates macrophage autophagy and responses to intracellular infection. FEBS Lett. 2020 09; 594(17):2782-2799. PMID: 32484234.
    Citations:    Fields:    
  3. Mandarino A, Gregory DJ, McGuire CC, Leblanc BW, Witt H, Rivera LM, Godleski JJ, Fedulov AV. The effect of talc particles on phagocytes in co-culture with ovarian cancer cells. Environ Res. 2020 01; 180:108676. PMID: 31785414.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Campion A, Smith KJ, Fedulov AV, Gregory DZ, Fan Y, Godleski JJ. Identification of Foreign Particles in Human Tissues Using Raman Microscopy. Anal Chem. 2018 07 17; 90(14):8362-8369. PMID: 29894163.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Gregory DJ, Kramnik I, Kobzik L. Protection of macrophages from intracellular pathogens by miR-182-5p mimic-a gene expression meta-analysis approach. FEBS J. 2018 01; 285(2):244-260. PMID: 29197182.
    Citations: 1     Fields:    Translation:HumansCells
  6. Gregory DJ, Kobzik L, Yang Z, McGuire CC, Fedulov AV. Transgenerational transmission of asthma risk after exposure to environmental particles during pregnancy. . 2017 08 01; 313(2):L395-L405. PMID: 28495853.
    Citations: 10     Translation:AnimalsCellsPHPublic Health
  7. Dohmen LC, Navas A, Vargas DA, Gregory DJ, Kip A, Dorlo TP, Gomez MA. Functional Validation of ABCA3 as a Miltefosine Transporter in Human Macrophages: IMPACT ON INTRACELLULAR SURVIVAL OF LEISHMANIA (VIANNIA) PANAMENSIS. J Biol Chem. 2016 Apr 29; 291(18):9638-47. PMID: 26903515.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Gregory DJ, Kobzik L. Influenza lung injury: mechanisms and therapeutic opportunities. . 2015 Nov 15; 309(10):L1041-6. PMID: 26408556.
    Citations: 14     Translation:HumansAnimalsCells
  9. Gregory DJ, Zhang Y, Kobzik L, Fedulov AV. Specific transcriptional enhancement of inducible nitric oxide synthase by targeted promoter demethylation. Epigenetics. 2013 Nov; 8(11):1205-12. PMID: 24008769.
    Citations: 16     Fields:    Translation:AnimalsCells
  10. Gregory DJ. Triggering receptor expressed on myeloid cells-2: a new ally against sepsis. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):125-6. PMID: 23855687.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Gregory DJ, Mikhaylova L, Fedulov AV. Selective DNA demethylation by fusion of TDG with a sequence-specific DNA-binding domain. Epigenetics. 2012 Apr; 7(4):344-9. PMID: 22419066.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  12. Zhou H, DeLoid G, Browning E, Gregory DJ, Tan F, Bedugnis AS, Imrich A, Koziel H, Kramnik I, Lu Q, Kobzik L. Genome-wide RNAi screen in IFN-?-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PLoS One. 2012; 7(2):e31752. PMID: 22359626.
    Citations: 12     Fields:    Translation:HumansCells
  13. Ghosh S, Gregory D, Smith A, Kobzik L. MARCO regulates early inflammatory responses against influenza: a useful macrophage function with adverse outcome. Am J Respir Cell Mol Biol. 2011 Nov; 45(5):1036-44. PMID: 21562316.
    Citations: 29     Fields:    Translation:AnimalsCells
  14. Gregory DJ, Godbout M, Contreras I, Forget G, Olivier M. A novel form of NF-kappaB is induced by Leishmania infection: involvement in macrophage gene expression. Eur J Immunol. 2008 Apr; 38(4):1071-81. PMID: 18383035.
    Citations: 41     Fields:    Translation:AnimalsCells
  15. Olivier M, Gregory DJ. In Leishmania after the genome: biology and control, Myler PJ & Fasel N, editors. Chapter 11: Leishmania-macrophage interaction. 2008.
  16. Gregory DJ, Sladek R, Olivier M, Matlashewski G. Comparison of the effects of Leishmania major or Leishmania donovani infection on macrophage gene expression. Infect Immun. 2008 Mar; 76(3):1186-92. PMID: 18086813.
    Citations: 30     Fields:    Translation:AnimalsCells
  17. Forget G, Gregory DJ, Whitcombe LA, Olivier M. Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani-induced inhibition of nitric oxide production. Infect Immun. 2006 Nov; 74(11):6272-9. PMID: 17057094.
    Citations: 49     Fields:    Translation:AnimalsCells
  18. Forget G, Gregory DJ, Olivier M. Proteasome-mediated degradation of STAT1alpha following infection of macrophages with Leishmania donovani. J Biol Chem. 2005 Aug 26; 280(34):30542-9. PMID: 15983048.
    Citations: 37     Fields:    Translation:AnimalsCells
  19. Olivier M, Gregory DJ, Forget G. Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view. Clin Microbiol Rev. 2005 Apr; 18(2):293-305. PMID: 15831826.
    Citations: 160     Fields:    Translation:HumansAnimalsCells
  20. Bates GJ, Nicol SM, Wilson BJ, Jacobs AM, Bourdon JC, Wardrop J, Gregory DJ, Lane DP, Perkins ND, Fuller-Pace FV. The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor. EMBO J. 2005 Feb 09; 24(3):543-53. PMID: 15660129.
    Citations: 96     Fields:    Translation:HumansCells
  21. Gregory DJ, Olivier M. Subversion of host cell signalling by the protozoan parasite Leishmania. Parasitology. 2005; 130 Suppl:S27-35. PMID: 16281989.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  22. Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV. The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner. BMC Mol Biol. 2004 Aug 06; 5:11. PMID: 15298701.
    Citations: 48     Fields:    Translation:HumansCells
  23. Maclaren A, Clark W, Black EJ, Gregory D, Fujii H, Gillespie DA. v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1. Oncogene. 2003 Apr 24; 22(16):2383-95. PMID: 12717415.
    Citations: 5     Fields:    Translation:AnimalsCells
  24. Gregory DJ, Garcia-Wilson E, Poole JC, Snowden AW, Roninson IB, Perkins ND. Induction of transcription through the p300 CRD1 motif by p21WAF1/CIP1 is core promoter specific and cyclin dependent kinase independent. . 2002 Sep-Oct; 1(5):343-50. PMID: 12461297.
    Citations: 6     Translation:Cells
  25. Mouchel N, Tebbutt SJ, Broackes-Carter FC, Sahota V, Summerfield T, Gregory DJ, Harris A. The sheep genome contributes to localization of control elements in a human gene with complex regulatory mechanisms. Genomics. 2001 Aug; 76(1-3):9-13. PMID: 11549312.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.