Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

William Taylor Kimberly, Ph.D., M.D.

Title
Institution
Department
Address
Phone

Mentoring
Available: 01/01/19, Expires: 12/31/21

The Kimberly lab studies the determinants of cerebral edema and ischemia in acute stroke. Using biomarkers, brain MRI analysis and models systems, we focus on better understanding the biological pathways that lead to secondary neurological injury after stroke. Students would participate in ongoing biomarker and clinical sample analyses, with ample opportunity for independent research. Specific projects would depend on student interest, skills and the current status of the projects at time they join our group. We have several exciting projects that bridge basic biology, models systems and connect them to patients and patients' samples.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS099209 (KIMBERLY, WILLIAM TAYLOR) Dec 1, 2016 - Nov 30, 2021
    NIH/NINDS
    Metabolomic predictors of stroke in REGARDS
    Role: Principal Investigator
  2. K23NS076597 (KIMBERLY, WILLIAM TAYLOR) Sep 1, 2011 - Aug 31, 2016
    NIH/NINDS
    Metabolomic analysis of acute stress hyperglycemia in ischemic stroke
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Winzeck S, Mocking SJT, Bezerra R, Bouts MJRJ, McIntosh EC, Diwan I, Garg P, Chutinet A, Kimberly WT, Copen WA, Schaefer PW, Ay H, Singhal AB, Kamnitsas K, Glocker B, Sorensen AG, Wu O. Ensemble of Convolutional Neural Networks Improves Automated Segmentation of Acute Ischemic Lesions Using Multiparametric Diffusion-Weighted MRI. AJNR Am J Neuroradiol. 2019 May 30. PMID: 31147354.
    Citations:    
  2. Rao SS, Chung DY, Wolcott Z, Sheriff F, Khawaja AM, Lee H, Guanci MM, Leslie-Mazwi TM, Kimberly WT, Patel AB, Rordorf GA. Intermittent CSF drainage and rapid EVD weaning approach after subarachnoid hemorrhage: association with fewer VP shunts and shorter length of stay. J Neurosurg. 2019 Apr 26; 1-6. PMID: 31026832.
    Citations:    
  3. Nelson SE, Ament Z, Wolcott Z, Gerszten RE, Kimberly WT. Succinate links atrial dysfunction and cardioembolic stroke. Neurology. 2019 Feb 19; 92(8):e802-e810. PMID: 30674589.
    Citations:    Fields:    
  4. Kimberly WT, Bevers MB, von Kummer R, Demchuk AM, Romero JM, Elm JJ, Hinson HE, Molyneaux BJ, Simard JM, Sheth KN. Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial. Neurology. 2018 Dec 04; 91(23):e2163-e2169. PMID: 30446594.
    Citations:    Fields:    
  5. King ZA, Sheth KN, Kimberly WT, Simard JM. Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date. Drug Des Devel Ther. 2018; 12:2539-2552. PMID: 30147301.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Hayman EG, Patel AP, Kimberly WT, Sheth KN, Simard JM. Cerebral Edema After Cardiopulmonary Resuscitation: A Therapeutic Target Following Cardiac Arrest? Neurocrit Care. 2018 06; 28(3):276-287. PMID: 29080068.
    Citations: 2     Fields:    
  7. Ostwaldt AC, Battey TWK, Irvine HJ, Campbell BCV, Davis SM, Donnan GA, Kimberly WT. Comparative Analysis of Markers of Mass Effect after Ischemic Stroke. J Neuroimaging. 2018 Sep; 28(5):530-534. PMID: 29797614.
    Citations:    Fields:    
  8. Sheth KN, Petersen NH, Cheung K, Elm JJ, Hinson HE, Molyneaux BJ, Beslow LA, Sze GK, Simard JM, Kimberly WT. Long-Term Outcomes in Patients Aged =70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis. Stroke. 2018 Jun; 49(6):1457-1463. PMID: 29789393.
    Citations:    Fields:    
  9. Kimberly WT, Dutra BG, Boers AMM, Alves HCBR, Berkhemer OA, van den Berg L, Sheth KN, Roos YBWEM, van der Lugt A, Beenen LFM, Dippel DWJ, van Zwam WH, van Oostenbrugge RJ, Lingsma HF, Marquering H, Majoie CBLM. Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial. JAMA Neurol. 2018 Apr 01; 75(4):453-461. PMID: 29365017.
    Citations: 1     Fields:    
  10. Bevers MB, Battey TWK, Ostwaldt AC, Jahan R, Saver JL, Kimberly WT, Kidwell CS. Apparent Diffusion Coefficient Signal Intensity Ratio Predicts the Effect of Revascularization on Ischemic Cerebral Edema. Cerebrovasc Dis. 2018; 45(3-4):93-100. PMID: 29533946.
    Citations: 1     Fields:    
  11. Irvine HJ, Ostwaldt AC, Bevers MB, Dixon S, Battey TW, Campbell BC, Davis SM, Donnan GA, Sheth KN, Jahan R, Saver JL, Kidwell CS, Kimberly WT. Reperfusion after ischemic stroke is associated with reduced brain edema. J Cereb Blood Flow Metab. 2018 Oct; 38(10):1807-1817. PMID: 28731381.
    Citations: 2     Fields:    
  12. Wolcott Z, Batra A, Bevers MB, Sastre C, Khoury J, Sperling M, Meyer BC, Walsh KB, Adeoye O, Broderick JP, Kimberly WT. Soluble ST2 predicts outcome and hemorrhagic transformation after acute stroke. Ann Clin Transl Neurol. 2017 08; 4(8):553-563. PMID: 28812045.
    Citations:    
  13. Bevers MB, Kimberly WT. Critical Care Management of Acute Ischemic Stroke. Curr Treat Options Cardiovasc Med. 2017 Jun; 19(6):41. PMID: 28466119.
    Citations: 2     
  14. Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE. Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI Insight. 2017 May 04; 2(9). PMID: 28469090.
    Citations: 2     Fields:    
  15. Grunwald Z, Beslow LA, Urday S, Vashkevich A, Ayres A, Greenberg SM, Goldstein JN, Leasure A, Shi FD, Kahle KT, Battey TW, Simard JM, Rosand J, Kimberly WT, Sheth KN. Perihematomal Edema Expansion Rates and Patient Outcomes in Deep and Lobar Intracerebral Hemorrhage. Neurocrit Care. 2017 04; 26(2):205-212. PMID: 27844466.
    Citations: 1     Fields:    Translation:Humans
  16. Shah S, Kimberly WT. Today's Approach to Treating Brain Swelling in the Neuro Intensive Care Unit. Semin Neurol. 2016 Dec; 36(6):502-507. PMID: 27907954.
    Citations:    
  17. Sheth KN, Elm JJ, Molyneaux BJ, Hinson H, Beslow LA, Sze GK, Ostwaldt AC, Del Zoppo GJ, Simard JM, Jacobson S, Kimberly WT. Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet Neurol. 2016 Oct; 15(11):1160-9. PMID: 27567243.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  18. Murthy SB, Urday S, Beslow LA, Dawson J, Lees K, Kimberly WT, Iadecola C, Kamel H, Hanley DF, Sheth KN, Ziai WC. Rate of perihaematomal oedema expansion is associated with poor clinical outcomes in intracerebral haemorrhage. J Neurol Neurosurg Psychiatry. 2016 Nov; 87(11):1169-1173. PMID: 27466360.
    Citations:    Fields:    Translation:Humans
  19. Irvine HJ, Battey TW, Ostwaldt AC, Campbell BC, Davis SM, Donnan GA, Sheth KN, Kimberly WT. Early neurological stability predicts adverse outcome after acute ischemic stroke. Int J Stroke. 2016 10; 11(8):882-889. PMID: 27334760.
    Citations: 1     Fields:    Translation:Humans
  20. Asuzu D, Nyström K, Sreekrishnan A, Schindler J, Wira C, Greer D, Halliday J, Kimberly WT, Sheth KN. TURN Score Predicts 24-Hour Cerebral Edema After IV Thrombolysis. Neurocrit Care. 2016 06; 24(3):381-8. PMID: 26341364.
    Citations: 1     Fields:    Translation:Humans
  21. Urday S, Beslow LA, Dai F, Zhang F, Battey TW, Vashkevich A, Ayres AM, Leasure AC, Selim MH, Simard JM, Rosand J, Kimberly WT, Sheth KN. Rate of Perihematomal Edema Expansion Predicts Outcome After Intracerebral Hemorrhage. Crit Care Med. 2016 Apr; 44(4):790-7. PMID: 26757167.
    Citations: 5     Fields:    Translation:Humans
  22. Sheth KN, Elm JJ, Beslow LA, Sze GK, Kimberly WT. Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial: Rationale and Design. Neurocrit Care. 2016 Feb; 24(1):132-9. PMID: 26268138.
    Citations: 11     Fields:    Translation:Humans
  23. Leasure A, Kimberly WT, Sansing LH, Kahle KT, Kronenberg G, Kunte H, Simard JM, Sheth KN. Treatment of Edema Associated With Intracerebral Hemorrhage. Curr Treat Options Neurol. 2016 Feb; 18(2):9. PMID: 26874842.
    Citations: 3     
  24. Wang W, Shen G, Shahar E, Bidulescu A, Kimberly WT, Sheth KN, Campbell BW, Horbal S, Correa A, Griswold ME. Forced Expiratory Volume in the First Second and Aldosterone as Mediators of Smoking Effect on Stroke in African Americans: The Jackson Heart Study. J Am Heart Assoc. 2016 Jan 27; 5(1). PMID: 26819252.
    Citations:    Fields:    Translation:HumansCells
  25. Kimberly WT, Battey TW, Wu O, Singhal AB, Campbell BC, Davis SM, Donnan GA, Sheth KN. Novel Imaging Markers of Ischemic Cerebral Edema and Its Association with Neurological Outcome. Acta Neurochir Suppl. 2016; 121:223-6. PMID: 26463953.
    Citations: 1     Fields:    Translation:Humans
  26. Sheth KN, Simard JM, Elm J, Kronenberg G, Kunte H, Kimberly WT. Human Data Supporting Glyburide in Ischemic Stroke. Acta Neurochir Suppl. 2016; 121:13-8. PMID: 26463916.
    Citations:    Fields:    Translation:Humans
  27. Bevers MB, Vaishnav NH, Pham L, Battey TW, Kimberly WT. Hyperglycemia is associated with more severe cytotoxic injury after stroke. J Cereb Blood Flow Metab. 2017 Jul; 37(7):2577-2583. PMID: 27671250.
    Citations: 4     Fields:    Translation:Humans
  28. Poston JT, McSparron JI, Hayes MM, Damm T, Patel JJ, Decker BK, Attia EF, Çoruh B, Cai X, Kimberly WT, Poisson SN, Sokol S, Csikesz N, Levinson AT, Thomson CC, Luks AM. ATS Core Curriculum 2015: Part IV. Adult Critical Care Medicine. Ann Am Thorac Soc. 2015 Dec; 12(12):1864-72. PMID: 26653191.
    Citations:    Fields:    Translation:Humans
  29. Lewis A, Wahlster S, Karinja S, Czeisler BM, Kimberly WT, Lord AS. Ventriculostomy-related infections: The performance of different definitions for diagnosing infection. Br J Neurosurg. 2016; 30(1):49-56. PMID: 26372297.
    Citations: 2     Fields:    Translation:Humans
  30. Urday S, Beslow LA, Goldstein DW, Vashkevich A, Ayres AM, Battey TW, Selim MH, Kimberly WT, Rosand J, Sheth KN. Measurement of perihematomal edema in intracerebral hemorrhage. Stroke. 2015 Apr; 46(4):1116-9. PMID: 25721012.
    Citations: 12     Fields:    Translation:Humans
  31. Urday S, Kimberly WT, Beslow LA, Vortmeyer AO, Selim MH, Rosand J, Simard JM, Sheth KN. Targeting secondary injury in intracerebral haemorrhage--perihaematomal oedema. Nat Rev Neurol. 2015 Feb; 11(2):111-22. PMID: 25623787.
    Citations: 25     Fields:    Translation:Humans
  32. Stahl DL, North CM, Lewis A, Kimberly WT, Hess DR. Case scenario: power of positive end-expiratory pressure: use of esophageal manometry to illustrate pulmonary physiology in an obese patient. Anesthesiology. 2014 Dec; 121(6):1320-6. PMID: 25057842.
    Citations: 2     Fields:    Translation:Humans
  33. Battey TW, Karki M, Singhal AB, Wu O, Sadaghiani S, Campbell BC, Davis SM, Donnan GA, Sheth KN, Kimberly WT. Brain edema predicts outcome after nonlacunar ischemic stroke. Stroke. 2014 Dec; 45(12):3643-8. PMID: 25336512.
    Citations: 20     Fields:    Translation:Humans
  34. Lewis A, Irvine H, Ogilvy C, Kimberly WT. Predictors for delayed ventriculoperitoneal shunt placement after external ventricular drain removal in patients with subarachnoid hemorrhage. Br J Neurosurg. 2015 Apr; 29(2):219-24. PMID: 25299790.
    Citations: 2     Fields:    Translation:Humans
  35. Walcott BP, Miller JC, Kwon CS, Sheth SA, Hiller M, Cronin CA, Schwamm LH, Simard JM, Kahle KT, Kimberly WT, Sheth KN. Outcomes in severe middle cerebral artery ischemic stroke. Neurocrit Care. 2014 Aug; 21(1):20-6. PMID: 23839704.
    Citations: 8     Fields:    Translation:Humans
  36. Sheth KN, Kimberly WT, Elm JJ, Kent TA, Yoo AJ, Thomalla G, Campbell B, Donnan GA, Davis SM, Albers GW, Jacobson S, del Zoppo G, Simard JM, Stern BJ, Mandava P. Exploratory analysis of glyburide as a novel therapy for preventing brain swelling. Neurocrit Care. 2014 Aug; 21(1):43-51. PMID: 24671831.
    Citations: 9     Fields:    Translation:Humans
  37. Bell DL, Kimberly WT, Yoo AJ, Leslie-Mazwi TM, Rabinov JD, Bell JE, Mehta BP, Hirsch JA. Low neurologic intensive care unit hemoglobin as a predictor for intra-arterial vasospasm therapy and poor discharge modified Rankin Scale in aneurysmal subarachnoid haemorrhage-induced cerebral vasospasm. J Neurointerv Surg. 2015 Jun; 7(6):438-42. PMID: 24814068.
    Citations: 1     Fields:    Translation:Humans
  38. Kimberly WT, Battey TW, Pham L, Wu O, Yoo AJ, Furie KL, Singhal AB, Elm JJ, Stern BJ, Sheth KN. Glyburide is associated with attenuated vasogenic edema in stroke patients. Neurocrit Care. 2014 Apr; 20(2):193-201. PMID: 24072459.
    Citations: 27     Fields:    Translation:Humans
  39. Simard JM, Sheth KN, Kimberly WT, Stern BJ, del Zoppo GJ, Jacobson S, Gerzanich V. Glibenclamide in cerebral ischemia and stroke. Neurocrit Care. 2014 Apr; 20(2):319-33. PMID: 24132564.
    Citations: 12     Fields:    Translation:HumansAnimals
  40. Jha R, Battey TW, Pham L, Lorenzano S, Furie KL, Sheth KN, Kimberly WT. Fluid-attenuated inversion recovery hyperintensity correlates with matrix metalloproteinase-9 level and hemorrhagic transformation in acute ischemic stroke. Stroke. 2014 Apr; 45(4):1040-5. PMID: 24619394.
    Citations: 9     Fields:    Translation:Humans
  41. Wijdicks EF, Sheth KN, Carter BS, Greer DM, Kasner SE, Kimberly WT, Schwab S, Smith EE, Tamargo RJ, Wintermark M. Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014 Apr; 45(4):1222-38. PMID: 24481970.
    Citations: 56     Fields:    Translation:Humans
  42. Sheth KN, Kimberly WT, Elm JJ, Kent TA, Mandava P, Yoo AJ, Thomalla G, Campbell B, Donnan GA, Davis SM, Albers GW, Jacobson S, Simard JM, Stern BJ. Pilot study of intravenous glyburide in patients with a large ischemic stroke. Stroke. 2014 Jan; 45(1):281-3. PMID: 24193798.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  43. Walcott BP, Kamel H, Castro B, Kimberly WT, Sheth KN. Tracheostomy after severe ischemic stroke: a population-based study. J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):1024-9. PMID: 24103666.
    Citations: 8     Fields:    Translation:Humans
  44. Brouwers HB, Backes D, Kimberly WT, Schwab K, Romero JM, Velthuis BK, Klijn CJ, Ogilvy CS, Regli L, Greenberg SM, Rosand J, Rinkel GJ, Goldstein JN. Computed tomography angiography spot sign does not predict case fatality in aneurysmal subarachnoid hemorrhage with intraparenchymal extension. Stroke. 2013 Jun; 44(6):1590-4. PMID: 23572475.
    Citations: 1     Fields:    Translation:Humans
  45. Kimberly WT, Wang Y, Pham L, Furie KL, Gerszten RE. Metabolite profiling identifies a branched chain amino acid signature in acute cardioembolic stroke. Stroke. 2013 May; 44(5):1389-95. PMID: 23520238.
    Citations: 11     Fields:    Translation:HumansAnimals
  46. Kimberly WT, Lima FO, O'Connor S, Furie KL. Sex differences and hemoglobin levels in relation to stroke outcomes. Neurology. 2013 Feb 19; 80(8):719-24. PMID: 23365064.
    Citations: 4     Fields:    Translation:Humans
  47. Hanak BW, Walcott BP, Nahed BV, Muzikansky A, Mian MK, Kimberly WT, Curry WT. Postoperative intensive care unit requirements after elective craniotomy. World Neurosurg. 2014 Jan; 81(1):165-72. PMID: 23182731.
    Citations: 3     Fields:    Translation:Humans
  48. Simard JM, Geng Z, Silver FL, Sheth KN, Kimberly WT, Stern BJ, Colucci M, Gerzanich V. Does inhibiting Sur1 complement rt-PA in cerebral ischemia? Ann N Y Acad Sci. 2012 Sep; 1268:95-107. PMID: 22994227.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  49. O'Connor S, Ayres A, Cortellini L, Rosand J, Rosenthal E, Kimberly WT. Process improvement methods increase the efficiency, accuracy, and utility of a neurocritical care research repository. Neurocrit Care. 2012 Aug; 17(1):90-6. PMID: 22434546.
    Citations: 1     Fields:    Translation:Humans
  50. Yoo AJ, Sheth KN, Kimberly WT, Chaudhry ZA, Elm JJ, Jacobson S, Davis SM, Donnan GA, Albers GW, Stern BJ, González RG. Validating imaging biomarkers of cerebral edema in patients with severe ischemic stroke. J Stroke Cerebrovasc Dis. 2013 Aug; 22(6):742-9. PMID: 22325573.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  51. Kimberly WT. Biomarkers in neurocritical care. Neurotherapeutics. 2012 Jan; 9(1):17-23. PMID: 22105793.
    Citations: 2     Fields:    Translation:Humans
  52. Kimberly WT, Wu O, Arsava EM, Garg P, Ji R, Vangel M, Singhal AB, Ay H, Sorensen AG. Lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke. Cerebrovasc Dis Extra. 2011 Jan-Dec; 1(1):44-53. PMID: 22566982.
    Citations: 5     Fields:    
  53. Kimberly WT, Sheth KN. Approach to severe hemispheric stroke. Neurology. 2011 Feb 15; 76(7 Suppl 2):S50-6. PMID: 21321352.
    Citations: 8     Fields:    Translation:Humans
  54. Kimberly WT, Gilson A, Rost NS, Rosand J, Viswanathan A, Smith EE, Greenberg SM. Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy. Neurology. 2009 Apr 07; 72(14):1230-5. PMID: 19349602.
    Citations: 54     Fields:    Translation:Humans
  55. Singhal AB, Kimberly WT, Schaefer PW, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 8-2009. A 36-year-old woman with headache, hypertension, and seizure 2 weeks post partum. N Engl J Med. 2009 Mar 12; 360(11):1126-37. PMID: 19279345.
    Citations: 15     Fields:    Translation:Humans
  56. Kimberly WT, Zheng JB, Town T, Flavell RA, Selkoe DJ. Physiological regulation of the beta-amyloid precursor protein signaling domain by c-Jun N-terminal kinase JNK3 during neuronal differentiation. J Neurosci. 2005 Jun 08; 25(23):5533-43. PMID: 15944381.
    Citations: 44     Fields:    Translation:AnimalsCells
  57. Kimberly WT, Wolfe MS. Identity and function of gamma-secretase. J Neurosci Res. 2003 Nov 01; 74(3):353-60. PMID: 14598311.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  58. LaVoie MJ, Fraering PC, Ostaszewski BL, Ye W, Kimberly WT, Wolfe MS, Selkoe DJ. Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem. 2003 Sep 26; 278(39):37213-22. PMID: 12857757.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  59. Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6382-7. PMID: 12740439.
    Citations: 204     Fields:    Translation:Animals
  60. Kimberly WT, Esler WP, Ye W, Ostaszewski BL, Gao J, Diehl T, Selkoe DJ, Wolfe MS. Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry. 2003 Jan 14; 42(1):137-44. PMID: 12515548.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  61. Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ. Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem. 2002 Sep 20; 277(38):35113-7. PMID: 12130643.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  62. Esler WP, Kimberly WT, Ostaszewski BL, Ye W, Diehl TS, Selkoe DJ, Wolfe MS. Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A. 2002 Mar 05; 99(5):2720-5. PMID: 11867728.
    Citations: 80     Fields:    Translation:AnimalsCells
  63. Kimberly WT, Zheng JB, Guénette SY, Selkoe DJ. The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner. J Biol Chem. 2001 Oct 26; 276(43):40288-92. PMID: 11544248.
    Citations: 105     Fields:    Translation:Cells
  64. Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation. Proc Natl Acad Sci U S A. 2000 Aug 01; 97(16):9299-304. PMID: 10922078.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  65. Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1. Nat Cell Biol. 2000 Jul; 2(7):428-34. PMID: 10878808.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  66. Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation. J Biol Chem. 2000 Feb 04; 275(5):3173-8. PMID: 10652302.
    Citations: 45     Fields:    Translation:AnimalsCells
  67. Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature. 1999 Apr 08; 398(6727):513-7. PMID: 10206644.
    Citations: 434     Fields:    Translation:HumansAnimalsCells
  68. Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 1998 Nov 24; 37(47):16465-71. PMID: 9843412.
    Citations: 42     Fields:    Translation:AnimalsCells
  69. Dobbelstein M, Roth J, Kimberly WT, Levine AJ, Shenk T. Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J. 1997 Jul 16; 16(14):4276-84. PMID: 9250671.
    Citations: 76     Fields:    Translation:HumansCells
  70. Porges AJ, Redecha PB, Kimberly WT, Csernok E, Gross WL, Kimberly RP. Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via Fc gamma RIIa. J Immunol. 1994 Aug 01; 153(3):1271-80. PMID: 8027554.
    Citations: 58     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Kimberly's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (275)
Explore
_
Co-Authors (44)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.