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Dan Levy, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 2R01NS078263-05 (Dan Levy) Sep 1, 2018 - May 31, 2023
    NIH/NINDS
    MECHANISMS OF CSD-EVOKED PERSISTENT ACTIVATION OF MENINGEAL NOCICEPTORS
    Role: Principal Investigator
  2. R21NS101405 (LEVY, DAN) Apr 1, 2017 - Mar 31, 2019
    NIH/NINDS
    Chronic two-photon calcium imaging of intracranial meningeal afferents in awake behaving mice
    Role: Principal Investigator
  3. R01NS086830 (LEVY, DAN) Aug 15, 2014 - May 31, 2019
    NIH/NINDS
    Peripheral Mechanisms of Posttraumatic Headache
    Role: Principal Investigator
  4. R01NS078263 (LEVY, DAN) Jul 15, 2013 - May 31, 2023
    NIH/NINDS
    MECHANISMS OF CSD-EVOKED PERSISTENT ACTIVATION OF MENINGEAL NOCICEPTORS
    Role: Principal Investigator
  5. R21AA020305 (LEVY, DAN) Feb 10, 2012 - Jan 31, 2014
    NIH/NIAAA
    Mechanisms of Alcohol Hangover Headache
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bree D, Stratton J, Levy D. Increased severity of closed head injury or repetitive subconcussive head impacts enhances post-traumatic headache-like behaviors in a rat model. Cephalalgia. 2020 Jun 29; 333102420937664. PMID: 32600065.
    Citations:    
  2. Bree D, Mackenzie K, Stratton J, Levy D. Enhanced post-traumatic headache-like behaviors and diminished contribution of peripheral CGRP in female rats following a mild closed head injury. Cephalalgia. 2020 Jun; 40(7):748-760. PMID: 32077327.
    Citations:    
  3. Levy D, Gruener H, Riabinin M, Feingold Y, Schreiber S, Pick CG, Defrin R. Different clinical phenotypes of persistent post-traumatic headache exhibit distinct sensory profiles. Cephalalgia. 2020 Jun; 40(7):675-688. PMID: 31847569.
    Citations:    
  4. Eger M, Bader M, Bree D, Hadar R, Nemerovski A, Tam J, Levy D, Pick CG, Gabet Y. Bone Anabolic Response in the Calvaria Following Mild Traumatic Brain Injury is Mediated by the Cannabinoid-1 Receptor. Sci Rep. 2019 11 07; 9(1):16196. PMID: 31700010.
    Citations:    
  5. Bree D, Levy D. Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache. Pain. 2019 05; 160(5):1050-1058. PMID: 30624345.
    Citations:    Fields:    
  6. Bree D, Levy D. Strides Toward Better Understanding of Post-Traumatic Headache Pathophysiology Using Animal Models. Curr Pain Headache Rep. 2018 Aug 02; 22(10):67. PMID: 30073545.
    Citations:    Fields:    Translation:HumansAnimals
  7. Levy D, Labastida-Ramirez A, MaassenVanDenBrink A. Current understanding of meningeal and cerebral vascular function underlying migraine headache. Cephalalgia. 2019 11; 39(13):1606-1622. PMID: 29929378.
    Citations:    Fields:    
  8. Zhao J, Levy D. Dissociation between CSD-Evoked Metabolic Perturbations and Meningeal Afferent Activation and Sensitization: Implications for Mechanisms of Migraine Headache Onset. J Neurosci. 2018 05 30; 38(22):5053-5066. PMID: 29703787.
    Citations:    Fields:    
  9. Zhao J, Levy D. The CGRP receptor antagonist BIBN4096 inhibits prolonged meningeal afferent activation evoked by brief local K+ stimulation but not cortical spreading depression-induced afferent sensitization. Pain Rep. 2018 Jan; 3(1):e632. PMID: 29430561.
    Citations:    
  10. Levy D, Abdian L, Dekel-Steinkeller M, Defrin R. Experimental evidence for weaker endogenous inhibition of trigeminal pain than extra-trigeminal pain in healthy individuals. Cephalalgia. 2018 06; 38(7):1307-1315. PMID: 28990805.
    Citations:    Fields:    Translation:Humans
  11. Zhao J, Levy D. Cortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine. eNeuro. 2016 Nov-Dec; 3(6). PMID: 28127585.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. Bree D, Levy D. Development of CGRP-dependent pain and headache related behaviours in a rat model of concussion: Implications for mechanisms of post-traumatic headache. Cephalalgia. 2018 02; 38(2):246-258. PMID: 27899434.
    Citations: 2     Fields:    Translation:Animals
  13. Zhao J, Bree D, Harrington MG, Strassman AM, Levy D. Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine. Cephalalgia. 2017 Oct; 37(11):1017-1025. PMID: 27493234.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Levy D, Edut S, Baraz-Goldstein R, Rubovitch V, Defrin R, Bree D, Gariepy H, Zhao J, Pick CG. Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache. Cephalalgia. 2016 Sep; 36(10):915-23. PMID: 26566937.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Zhao J, Levy D. Modulation of intracranial meningeal nociceptor activity by cortical spreading depression: a reassessment. J Neurophysiol. 2015 Apr 01; 113(7):2778-85. PMID: 25695654.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Benromano T, Defrin R, Ahn AH, Zhao J, Pick CG, Levy D. Mild closed head injury promotes a selective trigeminal hypernociception: implications for the acute emergence of post-traumatic headache. Eur J Pain. 2015 May; 19(5):621-8. PMID: 25168788.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Zhao J, Levy D. The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior. Pain. 2014 Jul; 155(7):1392-400. PMID: 24769138.
    Citations: 12     Fields:    Translation:AnimalsCells
  18. Burstein R, Zhang X, Levy D, Aoki KR, Brin MF. Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains. Cephalalgia. 2014 Oct; 34(11):853-69. PMID: 24694964.
    Citations: 33     Fields:    Translation:AnimalsCells
  19. Zhang X, Kainz V, Zhao J, Strassman AM, Levy D. Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors. Ann Neurol. 2013 Jun; 73(6):741-50. PMID: 23447360.
    Citations: 13     Fields:    Translation:AnimalsCells
  20. Arakaki X, McCleary P, Techy M, Chiang J, Kuo L, Fonteh AN, Armstrong B, Levy D, Harrington MG. Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat. Fluids Barriers CNS. 2013 Mar 14; 10(1):14. PMID: 23497725.
    Citations: 5     Fields:    
  21. Boes T, Levy D. Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells. Cephalalgia. 2012 Sep; 32(12):924-31. PMID: 22833613.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Levy D. Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression. Curr Pain Headache Rep. 2012 Jun; 16(3):270-7. PMID: 22328144.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  23. Zhang X, Burstein R, Levy D. Local action of the proinflammatory cytokines IL-1ß and IL-6 on intracranial meningeal nociceptors. Cephalalgia. 2012 Jan; 32(1):66-72. PMID: 22144718.
    Citations: 15     Fields:    Translation:AnimalsCells
  24. Levy D, Moskowitz MA, Noseda R, Burstein R. Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence? Cephalalgia. 2012 May; 32(7):581-2. PMID: 21996564.
    Citations: 3     Fields:    Translation:Animals
  25. Levy D, Kainz V, Burstein R, Strassman AM. Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun. 2012 Feb; 26(2):311-7. PMID: 22019552.
    Citations: 30     Fields:    Translation:AnimalsCells
  26. Levy D, Burstein R. The vascular theory of migraine: leave it or love it? Ann Neurol. 2011 Apr; 69(4):600-1. PMID: 21520229.
    Citations: 8     Fields:    Translation:HumansCells
  27. Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 May; 69(5):855-65. PMID: 21416489.
    Citations: 66     Fields:    Translation:AnimalsCells
  28. Zhang XC, Kainz V, Burstein R, Levy D. Tumor necrosis factor-a induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 Jan; 152(1):140-9. PMID: 21036476.
    Citations: 33     Fields:    Translation:AnimalsCells
  29. Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14. PMID: 20592202.
    Citations: 78     Fields:    Translation:AnimalsCells
  30. Verster JC, Stephens R, Penning R, Rohsenow D, McGeary J, Levy D, McKinney A, Finnigan F, Piasecki TM, Adan A, Batty GD, Fliervoet LA, Heffernan T, Howland J, Kim DJ, Kruisselbrink LD, Ling J, McGregor N, Murphy RJ, van Nuland M, Oudelaar M, Parkes A, Prat G, Reed N, Slutske WS, Smith G, Young M. The alcohol hangover research group consensus statement on best practice in alcohol hangover research. Curr Drug Abuse Rev. 2010 Jun; 3(2):116-26. PMID: 20712593.
    Citations: 21     Fields:    Translation:Humans
  31. Levy D. Migraine pain and nociceptor activation--where do we stand? Headache. 2010 May; 50(5):909-16. PMID: 20546325.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  32. Levy D, Strassman AM, Burstein R. A critical view on the role of migraine triggers in the genesis of migraine pain. Headache. 2009 Jun; 49(6):953-7. PMID: 19545256.
    Citations: 21     Fields:    Translation:HumansCells
  33. Levy D. Migraine pain, meningeal inflammation, and mast cells. Curr Pain Headache Rep. 2009 Jun; 13(3):237-40. PMID: 19457286.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  34. Zhang XC, Kainz V, Jakubowski M, Burstein R, Strassman A, Levy D. Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett. 2009 Mar 06; 452(1):33-6. PMID: 19444941.
    Citations: 8     Fields:    Translation:AnimalsCells
  35. Zhang XC, Levy D. Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. Cephalalgia. 2008 Mar; 28(3):276-84. PMID: 18254896.
    Citations: 11     Fields:    Translation:AnimalsCells
  36. Levy D, Zhang XC, Jakubowski M, Burstein R. Sensitization of meningeal nociceptors: inhibition by naproxen. Eur J Neurosci. 2008 Feb; 27(4):917-22. PMID: 18333963.
    Citations: 12     Fields:    Translation:AnimalsCells
  37. Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein R. Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion. Neuroscience. 2007 Aug 24; 148(2):573-83. PMID: 17651900.
    Citations: 14     Fields:    Translation:AnimalsCells
  38. Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12. PMID: 17483291.
    Citations: 41     Fields:    Translation:AnimalsCells
  39. Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AM. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76. PMID: 17459586.
    Citations: 85     Fields:    Translation:AnimalsCells
  40. Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8. PMID: 16927959.
    Citations: 17     Fields:    Translation:HumansCells
  41. Strassman AM, Levy D. Response properties of dural nociceptors in relation to headache. J Neurophysiol. 2006 Mar; 95(3):1298-306. PMID: 16492942.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  42. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705. PMID: 16240341.
    Citations: 57     Fields:    Translation:AnimalsCells
  43. Zochodne DW, Levy D. Nitric oxide in damage, disease and repair of the peripheral nervous system. Cell Mol Biol (Noisy-le-grand). 2005 Sep 05; 51(3):255-67. PMID: 16191393.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  44. Jakubowski M, Levy D, Goor-Aryeh I, Collins B, Bajwa Z, Burstein R. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005 Jul-Aug; 45(7):850-61. PMID: 15985101.
    Citations: 47     Fields:    Translation:HumansAnimalsCTClinical Trials
  45. Burstein R, Levy D, Jakubowski M. Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine. Rev Neurol (Paris). 2005 Jul; 161(6-7):658-60. PMID: 16141951.
    Citations: 25     Fields:    Translation:HumansCells
  46. Burstein R, Jakubowski M, Levy D. Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005 May; 115(1-2):21-8. PMID: 15836966.
    Citations: 8     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  47. Strassman AM, Levy D. The anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons. Neuroreport. 2004 Jun 28; 15(9):1409-12. PMID: 15194863.
    Citations: 4     Fields:    Translation:AnimalsCells
  48. Strassman AM, Weissner W, Williams M, Ali S, Levy D. Axon diameters and intradural trajectories of the dural innervation in the rat. J Comp Neurol. 2004 May 31; 473(3):364-76. PMID: 15116396.
    Citations: 20     Fields:    Translation:AnimalsCells
  49. Levy D, Strassman AM. Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade. J Neurophysiol. 2004 Aug; 92(2):766-72. PMID: 15056690.
    Citations: 12     Fields:    Translation:AnimalsCells
  50. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4274-9. PMID: 15016917.
    Citations: 57     Fields:    Translation:AnimalsCells
  51. Levy D, Zochodne DW. NO pain: potential roles of nitric oxide in neuropathic pain. Pain Pract. 2004 Mar; 4(1):11-8. PMID: 17129298.
    Citations: 20     Fields:    
  52. Levy D, Strassman AM. Mechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura. J Neurophysiol. 2002 Dec; 88(6):3021-31. PMID: 12466427.
    Citations: 32     Fields:    Translation:AnimalsCells
  53. Levy D, Strassman AM. Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors. J Physiol. 2002 Jan 15; 538(Pt 2):483-93. PMID: 11790814.
    Citations: 23     Fields:    Translation:AnimalsCells
  54. Levy D, Kubes P, Zochodne DW. Delayed peripheral nerve degeneration, regeneration, and pain in mice lacking inducible nitric oxide synthase. J Neuropathol Exp Neurol. 2001 May; 60(5):411-21. PMID: 11379816.
    Citations: 18     Fields:    Translation:Animals
  55. Levy D, Tal M, Höke A, Zochodne DW. Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury. Eur J Neurosci. 2000 Jul; 12(7):2323-32. PMID: 10947811.
    Citations: 8     Fields:    Translation:AnimalsCells
  56. Levy D, Zochodne DW. Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. 2000 Jun; 86(3):265-71. PMID: 10812256.
    Citations: 16     Fields:    Translation:AnimalsCells
  57. Levy D, Höke A, Zochodne DW. Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain. Neurosci Lett. 1999 Feb 05; 260(3):207-9. PMID: 10076904.
    Citations: 19     Fields:    Translation:AnimalsCells
  58. Zochodne DW, Levy D, Zwiers H, Sun H, Rubin I, Cheng C, Lauritzen M. Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transected peripheral nerves. Neuroscience. 1999; 91(4):1515-27. PMID: 10391455.
    Citations: 5     Fields:    Translation:Animals
  59. Levy D, Zochodne DW. Local nitric oxide synthase activity in a model of neuropathic pain. Eur J Neurosci. 1998 May; 10(5):1846-55. PMID: 9751155.
    Citations: 14     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.