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Last Name

profileDan Levy, Ph.D.

TitleAssociate Professor of Anaesthesia
InstitutionBeth Israel Deaconess Medical Center
AddressBeth Israel Deaconess Medical Center
Anesthesia & Critical Care, DA 717
330 Brookline Ave
Boston MA 02215
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Available: 07/26/17, Expires: 12/30/18

Opportunities are available to study neural and glial mechanisms underlying the genesis of migraine and headaches due to traumatic brain injury (post-traumatic headache). Studies are using in vivo rodent models and employ electrophysiology, histology, behavioral as well as cutting edge optogenetic and chemogenetic methodologies

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21NS101405     (LEVY, DAN)Apr 1, 2017 - Mar 31, 2019
Chronic two-photon calcium imaging of intracranial meningeal afferents in awake behaving mice
Role: Principal Investigator

R01NS086830     (LEVY, DAN)Aug 15, 2014 - May 31, 2019
Peripheral Mechanisms of Posttraumatic Headache
Role: Principal Investigator

R01NS078263     (LEVY, DAN)Jul 15, 2013 - Apr 30, 2017
Mechanisms of CSD-evoked persistent activation of meningeal nociceptors
Role: Principal Investigator

R21AA020305     (LEVY, DAN)Feb 10, 2012 - Jan 31, 2014
Mechanisms of Alcohol Hangover Headache
Role: Principal Investigator

R21NS077882     (LEVY, DAN)Sep 1, 2011 - Aug 31, 2013
Calvarial periosteal afferents in post-traumatic headache
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Levy D, Edut S, Baraz-Goldstein R, Rubovitch V, Defrin R, Bree D, Gariepy H, Zhao J, Pick CG. Responses of dural mast cells in concussive and blast models of mild traumatic brain injury in mice: Potential implications for post-traumatic headache. Cephalalgia. 2016 Sep; 36(10):915-23. PMID: 26566937.
    View in: PubMed
  2. Benromano T, Defrin R, Ahn AH, Zhao J, Pick CG, Levy D. Mild closed head injury promotes a selective trigeminal hypernociception: implications for the acute emergence of post-traumatic headache. Eur J Pain. 2015 May; 19(5):621-8. PMID: 25168788; PMCID: PMC4345163.
  3. Zhao J, Levy D. The sensory innervation of the calvarial periosteum is nociceptive and contributes to headache-like behavior. Pain. 2014 Jul; 155(7):1392-400. PMID: 24769138; PMCID: PMC4058402.
  4. Burstein R, Zhang X, Levy D, Aoki KR, Brin MF. Selective inhibition of meningeal nociceptors by botulinum neurotoxin type A: therapeutic implications for migraine and other pains. Cephalalgia. 2014 Oct; 34(11):853-69. PMID: 24694964; PMCID: PMC4167963.
  5. Zhang X, Kainz V, Zhao J, Strassman AM, Levy D. Vascular extracellular signal-regulated kinase mediates migraine-related sensitization of meningeal nociceptors. Ann Neurol. 2013 Jun; 73(6):741-50. PMID: 23447360; PMCID: PMC3688635.
  6. Arakaki X, McCleary P, Techy M, Chiang J, Kuo L, Fonteh AN, Armstrong B, Levy D, Harrington MG. Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat. Fluids Barriers CNS. 2013 Mar 14; 10(1):14. PMID: 23497725; PMCID: PMC3636111.
  7. Boes T, Levy D. Influence of sex, estrous cycle, and estrogen on intracranial dural mast cells. Cephalalgia. 2012 Sep; 32(12):924-31. PMID: 22833613; PMCID: PMC4037908.
  8. Levy D. Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression. Curr Pain Headache Rep. 2012 Jun; 16(3):270-7. PMID: 22328144.
    View in: PubMed
  9. Zhang X, Burstein R, Levy D. Local action of the proinflammatory cytokines IL-1ß and IL-6 on intracranial meningeal nociceptors. Cephalalgia. 2012 Jan; 32(1):66-72. PMID: 22144718; PMCID: PMC3674888.
  10. Levy D, Moskowitz MA, Noseda R, Burstein R. Activation of the migraine pain pathway by cortical spreading depression: do we need more evidence? Cephalalgia. 2012 May; 32(7):581-2. PMID: 21996564; PMCID: PMC3698973.
  11. Levy D, Kainz V, Burstein R, Strassman AM. Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity. Brain Behav Immun. 2012 Feb; 26(2):311-7. PMID: 22019552; PMCID: PMC3264697.
  12. Levy D, Burstein R. The vascular theory of migraine: leave it or love it? Ann Neurol. 2011 Apr; 69(4):600-1. PMID: 21520229.
    View in: PubMed
  13. Zhang X, Levy D, Kainz V, Noseda R, Jakubowski M, Burstein R. Activation of central trigeminovascular neurons by cortical spreading depression. Ann Neurol. 2011 May; 69(5):855-65. PMID: 21416489; PMCID: PMC3174689.
  14. Zhang XC, Kainz V, Burstein R, Levy D. Tumor necrosis factor-a induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions. Pain. 2011 Jan; 152(1):140-9. PMID: 21036476; PMCID: PMC3391748.
  15. Zhang X, Levy D, Noseda R, Kainz V, Jakubowski M, Burstein R. Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura. J Neurosci. 2010 Jun 30; 30(26):8807-14. PMID: 20592202; PMCID: PMC2907647.
  16. Verster JC, Stephens R, Penning R, Rohsenow D, McGeary J, Levy D, McKinney A, Finnigan F, Piasecki TM, Adan A, Batty GD, Fliervoet LA, Heffernan T, Howland J, Kim DJ, Kruisselbrink LD, Ling J, McGregor N, Murphy RJ, van Nuland M, Oudelaar M, Parkes A, Prat G, Reed N, Slutske WS, Smith G, Young M. The alcohol hangover research group consensus statement on best practice in alcohol hangover research. Curr Drug Abuse Rev. 2010 Jun; 3(2):116-26. PMID: 20712593; PMCID: PMC3827719.
  17. Levy D. Migraine pain and nociceptor activation--where do we stand? Headache. 2010 May; 50(5):909-16. PMID: 20546325.
    View in: PubMed
  18. Levy D, Strassman AM, Burstein R. A critical view on the role of migraine triggers in the genesis of migraine pain. Headache. 2009 Jun; 49(6):953-7. PMID: 19545256.
    View in: PubMed
  19. Levy D. Migraine pain, meningeal inflammation, and mast cells. Curr Pain Headache Rep. 2009 Jun; 13(3):237-40. PMID: 19457286.
    View in: PubMed
  20. Zhang XC, Kainz V, Jakubowski M, Burstein R, Strassman A, Levy D. Localization of COX-1 and COX-2 in the intracranial dura mater of the rat. Neurosci Lett. 2009 Mar 06; 452(1):33-6. PMID: 19444941; PMCID: PMC2775514.
  21. Zhang XC, Levy D. Modulation of meningeal nociceptors mechanosensitivity by peripheral proteinase-activated receptor-2: the role of mast cells. Cephalalgia. 2008 Mar; 28(3):276-84. PMID: 18254896; PMCID: PMC2504502.
  22. Levy D, Zhang XC, Jakubowski M, Burstein R. Sensitization of meningeal nociceptors: inhibition by naproxen. Eur J Neurosci. 2008 Feb; 27(4):917-22. PMID: 18333963; PMCID: PMC2677814.
  23. Jakubowski M, Levy D, Kainz V, Zhang XC, Kosaras B, Burstein R. Sensitization of central trigeminovascular neurons: blockade by intravenous naproxen infusion. Neuroscience. 2007 Aug 24; 148(2):573-83. PMID: 17651900; PMCID: PMC2710388.
  24. Zhang XC, Strassman AM, Burstein R, Levy D. Sensitization and activation of intracranial meningeal nociceptors by mast cell mediators. J Pharmacol Exp Ther. 2007 Aug; 322(2):806-12. PMID: 17483291.
    View in: PubMed
  25. Levy D, Burstein R, Kainz V, Jakubowski M, Strassman AM. Mast cell degranulation activates a pain pathway underlying migraine headache. Pain. 2007 Jul; 130(1-2):166-76. PMID: 17459586; PMCID: PMC2045157.
  26. Levy D, Burstein R, Strassman AM. Mast cell involvement in the pathophysiology of migraine headache: A hypothesis. Headache. 2006 Jun; 46 Suppl 1:S13-8. PMID: 16927959.
    View in: PubMed
  27. Strassman AM, Levy D. Response properties of dural nociceptors in relation to headache. J Neurophysiol. 2006 Mar; 95(3):1298-306. PMID: 16492942.
    View in: PubMed
  28. Levy D, Burstein R, Strassman AM. Calcitonin gene-related peptide does not excite or sensitize meningeal nociceptors: implications for the pathophysiology of migraine. Ann Neurol. 2005 Nov; 58(5):698-705. PMID: 16240341.
    View in: PubMed
  29. Zochodne DW, Levy D. Nitric oxide in damage, disease and repair of the peripheral nervous system. Cell Mol Biol (Noisy-le-grand). 2005 Sep 05; 51(3):255-67. PMID: 16191393.
    View in: PubMed
  30. Jakubowski M, Levy D, Goor-Aryeh I, Collins B, Bajwa Z, Burstein R. Terminating migraine with allodynia and ongoing central sensitization using parenteral administration of COX1/COX2 inhibitors. Headache. 2005 Jul-Aug; 45(7):850-61. PMID: 15985101.
    View in: PubMed
  31. Burstein R, Levy D, Jakubowski M. Effects of sensitization of trigeminovascular neurons to triptan therapy during migraine. Rev Neurol (Paris). 2005 Jul; 161(6-7):658-60. PMID: 16141951.
    View in: PubMed
  32. Burstein R, Jakubowski M, Levy D. Anti-migraine action of triptans is preceded by transient aggravation of headache caused by activation of meningeal nociceptors. Pain. 2005 May; 115(1-2):21-8. PMID: 15836966.
    View in: PubMed
  33. Strassman AM, Levy D. The anti-migraine agent sumatriptan induces a calcium-dependent discharge in meningeal sensory neurons. Neuroreport. 2004 Jun 28; 15(9):1409-12. PMID: 15194863.
    View in: PubMed
  34. Strassman AM, Weissner W, Williams M, Ali S, Levy D. Axon diameters and intradural trajectories of the dural innervation in the rat. J Comp Neurol. 2004 May 31; 473(3):364-76. PMID: 15116396.
    View in: PubMed
  35. Levy D, Strassman AM. Modulation of dural nociceptor mechanosensitivity by the nitric oxide-cyclic GMP signaling cascade. J Neurophysiol. 2004 Aug; 92(2):766-72. PMID: 15056690.
    View in: PubMed
  36. Levy D, Jakubowski M, Burstein R. Disruption of communication between peripheral and central trigeminovascular neurons mediates the antimigraine action of 5HT 1B/1D receptor agonists. Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12):4274-9. PMID: 15016917; PMCID: PMC384731.
  37. Levy D, Zochodne DW. NO pain: potential roles of nitric oxide in neuropathic pain. Pain Pract. 2004 Mar; 4(1):11-8. PMID: 17129298.
    View in: PubMed
  38. Levy D, Strassman AM. Mechanical response properties of A and C primary afferent neurons innervating the rat intracranial dura. J Neurophysiol. 2002 Dec; 88(6):3021-31. PMID: 12466427.
    View in: PubMed
  39. Levy D, Strassman AM. Distinct sensitizing effects of the cAMP-PKA second messenger cascade on rat dural mechanonociceptors. J Physiol. 2002 Jan 15; 538(Pt 2):483-93. PMID: 11790814; PMCID: PMC2290080.
  40. Levy D, Kubes P, Zochodne DW. Delayed peripheral nerve degeneration, regeneration, and pain in mice lacking inducible nitric oxide synthase. J Neuropathol Exp Neurol. 2001 May; 60(5):411-21. PMID: 11379816.
    View in: PubMed
  41. Levy D, Tal M, Höke A, Zochodne DW. Transient action of the endothelial constitutive nitric oxide synthase (ecNOS) mediates the development of thermal hypersensitivity following peripheral nerve injury. Eur J Neurosci. 2000 Jul; 12(7):2323-32. PMID: 10947811.
    View in: PubMed
  42. Levy D, Zochodne DW. Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. 2000 Jun; 86(3):265-71. PMID: 10812256.
    View in: PubMed
  43. Levy D, Höke A, Zochodne DW. Local expression of inducible nitric oxide synthase in an animal model of neuropathic pain. Neurosci Lett. 1999 Feb 05; 260(3):207-9. PMID: 10076904.
    View in: PubMed
  44. Zochodne DW, Levy D, Zwiers H, Sun H, Rubin I, Cheng C, Lauritzen M. Evidence for nitric oxide and nitric oxide synthase activity in proximal stumps of transected peripheral nerves. Neuroscience. 1999; 91(4):1515-27. PMID: 10391455.
    View in: PubMed
  45. Levy D, Zochodne DW. Local nitric oxide synthase activity in a model of neuropathic pain. Eur J Neurosci. 1998 May; 10(5):1846-55. PMID: 9751155.
    View in: PubMed
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