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Last Name
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profileGordon Campbell Weir, M.D.

TitleProfessor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
One Joslin Place
Boston MA 02215
Phone617/732-2581
Fax617/732-2650
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U42RR016606     (WEIR, GORDON CAMPBELL)Sep 30, 2001 - Aug 31, 2007
NIH/NCRR
HUMAN PANCREATIC ISLET CELL RESOURCE
Role: Principal Investigator

U19DK061251     (HABENER, JOEL F)Sep 30, 2001 - Jul 31, 2007
NIH/NIDDK
Program Project,Restoration of Endocrine Pancreas Funct*
Role: Co-Principal Investigator

P01DK053087     (WEIR, GORDON CAMPBELL)Feb 15, 1998 - Nov 30, 2003
NIH/NIDDK
ISLET XENOTRANSPLANTATION--GENETIC APPROACHES TO PROBLEM
Role: Principal Investigator

R01DK050657     (WEIR, GORDON CAMPBELL)Feb 10, 1996 - Mar 31, 2008
NIH/NIDDK
Islet Transplantation - Protection by Immunobarriers
Role: Principal Investigator

P30DK036836     (KING, GEORGE L)Sep 30, 1986 - Mar 31, 2022
NIH/NIDDK
Diabetes Research Center
Role: Co-Principal Investigator
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This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Islet Isolation Core (JDC) - Core services (2)

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir S. ß Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell Metab. 2017 Apr 04; 25(4):898-910.e5. PMID: 28380379.
    View in: PubMed
  2. Ebrahimi A, Jung MH, Dreyfuss JM, Pan H, Sgroi D, Bonner-Weir S, Weir GC. Evidence of stress in ß cells obtained with laser capture microdissection from pancreases of brain dead donors. Islets. 2017 Mar 04; 9(2):19-29. PMID: 28252345.
    View in: PubMed
  3. Weir GC, Bonner-Weir S. Glucose Driven Changes in Beta Cell Identity Are Important for Function and Possibly Autoimmune Vulnerability during the Progression of Type 1 Diabetes. Front Genet. 2017; 8:2. PMID: 28174593.
    View in: PubMed
  4. Weir GC, Bonner-Weir S. GABA Signaling Stimulates ß Cell Regeneration in Diabetic Mice. Cell. 2017 01 12; 168(1-2):7-9. PMID: 28086099.
    View in: PubMed
  5. Dong Y, Wang W, Veiseh O, Appel EA, Xue K, Webber MJ, Tang BC, Yang XW, Weir GC, Langer R, Anderson DG. Injectable and Glucose-Responsive Hydrogels Based on Boronic Acid-Glucose Complexation. Langmuir. 2016 Aug 30; 32(34):8743-7. PMID: 27455412.
    View in: PubMed
  6. Shankar SS, Vella A, Raymond RH, Staten MA, Calle RA, Bergman RN, Cao C, Chen D, Cobelli C, Dalla Man C, Deeg M, Dong JQ, Lee DS, Polidori D, Robertson RP, Ruetten H, Stefanovski D, Vassileva MT, Weir GC, Fryburg DA. Standardized Mixed-Meal Tolerance and Arginine Stimulation Tests Provide Reproducible and Complementary Measures of ß-Cell Function: Results From the Foundation for the National Institutes of Health Biomarkers Consortium Investigative Series. Diabetes Care. 2016 Sep; 39(9):1602-13. PMID: 27407117; PMCID: PMC5001146 [Available on 09/01/17].
  7. Markmann JF, Bartlett ST, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, O'Connell PJ, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Khovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T. Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of ß-Cell Replacement. Transplantation. 2016 Jul; 100(7):e25-31. PMID: 27082827.
    View in: PubMed
  8. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Corrigendum: Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 Jun 09; 34(6):666. PMID: 27281428.
    View in: PubMed
  9. Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Apr; 22(4):446. PMID: 27050590.
    View in: PubMed
  10. Bonner-Weir S, Aguayo-Mazzucato C, Weir GC. Dynamic development of the pancreas from birth to adulthood. Ups J Med Sci. 2016 May; 121(2):155-8. PMID: 26998806; PMCID: PMC4900072.
  11. Kuznetsova A, Yu Y, Hollister-Lock J, Opare-Addo L, Rozzo A, Sadagurski M, Norquay L, Reed JE, El Khattabi I, Bonner-Weir S, Weir GC, Sharma A, White MF. Trimeprazine increases IRS2 in human islets and promotes pancreatic ß cell growth and function in mice. JCI Insight. 2016; 1(3). PMID: 27152363.
    View in: PubMed
  12. Molven A, Hollister-Lock J, Hu J, Martinez R, Njølstad PR, Liew CW, Weir G, Kulkarni RN. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Diabetes. 2016 Jun; 65(6):1672-8. PMID: 26953163; PMCID: PMC4878426 [Available on 06/01/17].
  13. Bartlett ST, Markmann JF, Johnson P, Korsgren O, Hering BJ, Scharp D, Kay TW, Bromberg J, Odorico JS, Weir GC, Bridges N, Kandaswamy R, Stock P, Friend P, Gotoh M, Cooper DK, Park CG, O'Connell P, Stabler C, Matsumoto S, Ludwig B, Choudhary P, Kovatchev B, Rickels MR, Sykes M, Wood K, Kraemer K, Hwa A, Stanley E, Ricordi C, Zimmerman M, Greenstein J, Montanya E, Otonkoski T. Report from IPITA-TTS Opinion Leaders Meeting on the Future of ß-Cell Replacement. Transplantation. 2016 Feb; 100 Suppl 2:S1-44. PMID: 26840096; PMCID: PMC4741413.
  14. Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, McGarrigle JJ, Bochenek MA, Hollister-Lock J, Oberholzer J, Greiner DL, Weir GC, Melton DA, Langer R, Anderson DG. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016 Mar; 22(3):306-11. PMID: 26808346; PMCID: PMC4825868.
  15. Vegas AJ, Veiseh O, Doloff JC, Ma M, Tam HH, Bratlie K, Li J, Bader AR, Langan E, Olejnik K, Fenton P, Kang JW, Hollister-Locke J, Bochenek MA, Chiu A, Siebert S, Tang K, Jhunjhunwala S, Aresta-Dasilva S, Dholakia N, Thakrar R, Vietti T, Chen M, Cohen J, Siniakowicz K, Qi M, McGarrigle J, Lyle S, Harlan DM, Greiner DL, Oberholzer J, Weir GC, Langer R, Anderson DG. Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates. Nat Biotechnol. 2016 Mar; 34(3):345-52. PMID: 26807527; PMCID: PMC4904301.
  16. Weir GC. Islet-cell biology in 2015: Understanding secretion, ageing and death in ß cells. Nat Rev Endocrinol. 2016 Feb; 12(2):72-4. PMID: 26729035.
    View in: PubMed
  17. Cavelti-Weder C, Li W, Zumsteg A, Stemann-Andersen M, Zhang Y, Yamada T, Wang M, Lu J, Jermendy A, Bee YM, Bonner-Weir S, Weir GC, Zhou Q. Hyperglycaemia attenuates in vivo reprogramming of pancreatic exocrine cells to beta cells in mice. Diabetologia. 2016 Mar; 59(3):522-32. PMID: 26693711; PMCID: PMC4744133 [Available on 03/01/17].
  18. Papas KK, Bellin MD, Sutherland DE, Suszynski TM, Kitzmann JP, Avgoustiniatos ES, Gruessner AC, Mueller KR, Beilman GJ, Balamurugan AN, Loganathan G, Colton CK, Koulmanda M, Weir GC, Wilhelm JJ, Qian D, Niland JC, Hering BJ. Islet Oxygen Consumption Rate (OCR) Dose Predicts Insulin Independence in Clinical Islet Autotransplantation. PLoS One. 2015; 10(8):e0134428. PMID: 26258815; PMCID: PMC4530873.
  19. Li W, Cavelti-Weder C, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D, Meissner A, Weir G, Zhou Q. Corrigendum: Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nat Biotechnol. 2015 Aug; 33(8):882. PMID: 26252147.
    View in: PubMed
  20. Aguayo-Mazzucato C, DiIenno A, Hollister-Lock J, Cahill C, Sharma A, Weir G, Colton C, Bonner-Weir S. MAFA and T3 Drive Maturation of Both Fetal Human Islets and Insulin-Producing Cells Differentiated From hESC. J Clin Endocrinol Metab. 2015 Oct; 100(10):3651-9. PMID: 26207953; PMCID: PMC4596039 [Available on 10/01/16].
  21. Veiseh O, Doloff JC, Ma M, Vegas AJ, Tam HH, Bader AR, Li J, Langan E, Wyckoff J, Loo WS, Jhunjhunwala S, Chiu A, Siebert S, Tang K, Hollister-Lock J, Aresta-Dasilva S, Bochenek M, Mendoza-Elias J, Wang Y, Qi M, Lavin DM, Chen M, Dholakia N, Thakrar R, Lacík I, Weir GC, Oberholzer J, Greiner DL, Langer R, Anderson DG. Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates. Nat Mater. 2015 Jun; 14(6):643-51. PMID: 25985456; PMCID: PMC4477281.
  22. Yamada T, Cavelti-Weder C, Caballero F, Lysy PA, Guo L, Sharma A, Li W, Zhou Q, Bonner-Weir S, Weir GC. Reprogramming Mouse Cells With a Pancreatic Duct Phenotype to Insulin-Producing ß-Like Cells. Endocrinology. 2015 Jun; 156(6):2029-38. PMID: 25836667; PMCID: PMC4430605.
  23. Cavelti-Weder C, Li W, Zumsteg A, Stemann M, Yamada T, Bonner-Weir S, Weir G, Zhou Q. Direct Reprogramming for Pancreatic Beta-Cells Using Key Developmental Genes. Curr Pathobiol Rep. 2015 Mar 01; 3(1):57-65. PMID: 26998407.
    View in: PubMed
  24. Bonner-Weir S, Sullivan BA, Weir GC. Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All. J Histochem Cytochem. 2015 Aug; 63(8):604-12. PMID: 25604813; PMCID: PMC4530393.
  25. Fonseca SG, Urano F, Weir GC, Gromada J, Burcin M. Retraction: Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol. 2014 Dec 23; 17(1):105. PMID: 25534090.
    View in: PubMed
  26. Sullivan BA, Hollister-Lock J, Bonner-Weir S, Weir GC. Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human ß-Cells. Diabetes. 2015 May; 64(5):1698-702. PMID: 25488899; PMCID: PMC4407864.
  27. Li W, Cavelti-Weder C, Zhang Y, Zhang Y, Clement K, Donovan S, Gonzalez G, Zhu J, Stemann M, Xu K, Hashimoto T, Yamada T, Nakanishi M, Zhang Y, Zeng S, Gifford D, Meissner A, Weir G, Zhou Q. Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells. Nat Biotechnol. 2014 Dec; 32(12):1223-30. PMID: 25402613.
    View in: PubMed
  28. Evron Y, Zimermann B, Ludwig B, Barkai U, Colton CK, Weir GC, Arieli B, Maimon S, Shalev N, Yavriyants K, Goldman T, Gendler Z, Eizen L, Vardi P, Bloch K, Barthel A, Bornstein SR, Rotem A. Oxygen supply by photosynthesis to an implantable islet cell device. Horm Metab Res. 2015 Jan; 47(1):24-30. PMID: 25365509.
    View in: PubMed
  29. Robertson RP, Raymond RH, Lee DS, Calle RA, Ghosh A, Savage PJ, Shankar SS, Vassileva MT, Weir GC, Fryburg DA. Arginine is preferred to glucagon for stimulation testing of ß-cell function. Am J Physiol Endocrinol Metab. 2014 Oct 15; 307(8):E720-7. PMID: 25159323; PMCID: PMC4200308.
  30. Zhao Z, Low YS, Armstrong NA, Ryu JH, Sun SA, Arvanites AC, Hollister-Lock J, Shah NH, Weir GC, Annes JP. Repurposing cAMP-modulating medications to promote ß-cell replication. Mol Endocrinol. 2014 Oct; 28(10):1682-97. PMID: 25083741; PMCID: PMC4179632.
  31. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. Diabetes Care. 2014 Jun; 37(6):1751-8. PMID: 24812433; PMCID: PMC4179518.
  32. Halban PA, Polonsky KS, Bowden DW, Hawkins MA, Ling C, Mather KJ, Powers AC, Rhodes CJ, Sussel L, Weir GC. ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment. J Clin Endocrinol Metab. 2014 Jun; 99(6):1983-92. PMID: 24712577.
    View in: PubMed
  33. Bonner-Weir S, In't Veld PA, Weir GC. Reanalysis of study of pancreatic effects of incretin therapy: methodological deficiencies. Diabetes Obes Metab. 2014 Jul; 16(7):661-6. PMID: 24400596.
    View in: PubMed
  34. Cavelti-Weder C, Li W, Weir GC, Zhou Q. Direct lineage conversion of pancreatic exocrine to endocrine Beta cells in vivo with defined factors. Methods Mol Biol. 2014; 1150:247-62. PMID: 24744004.
    View in: PubMed
  35. Weir GC, Aguayo-Mazzucato C, Bonner-Weir S. ß-cell dedifferentiation in diabetes is important, but what is it? Islets. 2013 Sep-Dec; 5(5):233-7. PMID: 24356710; PMCID: PMC4010577.
  36. King AJ, Guo Y, Cai D, Hollister-Lock J, Morris B, Salvatori A, Corbett JA, Bonner-Weir S, Shoelson SE, Weir GC. Sustained NF-?B activation and inhibition in ß-cells have minimal effects on function and islet transplant outcomes. PLoS One. 2013; 8(10):e77452. PMID: 24204831; PMCID: PMC3799630.
  37. Lysy PA, Weir GC, Bonner-Weir S. Making ß cells from adult cells within the pancreas. Curr Diab Rep. 2013 Oct; 13(5):695-703. PMID: 23925431; PMCID: PMC3798031.
  38. Cavelti-Weder C, Shtessel M, Reuss JE, Jermendy A, Yamada T, Caballero F, Bonner-Weir S, Weir GC. Pancreatic duct ligation after almost complete ß-cell loss: exocrine regeneration but no evidence of ß-cell regeneration. Endocrinology. 2013 Dec; 154(12):4493-502. PMID: 24029238; PMCID: PMC3836076.
  39. Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N. Genetic disruption of SOD1 gene causes glucose intolerance and impairs ß-cell function. Diabetes. 2013 Dec; 62(12):4201-7. PMID: 24009256; PMCID: PMC3837066.
  40. Neufeld T, Ludwig B, Barkai U, Weir GC, Colton CK, Evron Y, Balyura M, Yavriyants K, Zimermann B, Azarov D, Maimon S, Shabtay N, Rozenshtein T, Lorber D, Steffen A, Willenz U, Bloch K, Vardi P, Taube R, de Vos P, Lewis EC, Bornstein SR, Rotem A. The efficacy of an immunoisolating membrane system for islet xenotransplantation in minipigs. PLoS One. 2013; 8(8):e70150. PMID: 23936385; PMCID: PMC3731363.
  41. Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in ducts is not required for postnatal formation of ß-cells but is necessary for their subsequent maturation. Diabetes. 2013 Oct; 62(10):3459-68. PMID: 23775765; PMCID: PMC3781453.
  42. Dang TT, Thai AV, Cohen J, Slosberg JE, Siniakowicz K, Doloff JC, Ma M, Hollister-Lock J, Tang KM, Gu Z, Cheng H, Weir GC, Langer R, Anderson DG. Enhanced function of immuno-isolated islets in diabetes therapy by co-encapsulation with an anti-inflammatory drug. Biomaterials. 2013 Jul; 34(23):5792-801. PMID: 23660251; PMCID: PMC3901568.
  43. Weir GC. Islet encapsulation: advances and obstacles. Diabetologia. 2013 Jul; 56(7):1458-61. PMID: 23636639.
    View in: PubMed
  44. Weir GC, Bonner-Weir S. Islet ß cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci. 2013 Apr; 1281:92-105. PMID: 23363033; PMCID: PMC3618572.
  45. Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S. Thyroid hormone promotes postnatal rat pancreatic ß-cell development and glucose-responsive insulin secretion through MAFA. Diabetes. 2013 May; 62(5):1569-80. PMID: 23305647; PMCID: PMC3636623.
  46. Caballero F, Siniakowicz K, Hollister-Lock J, Duran L, Katsuta H, Yamada T, Lei J, Deng S, Westermark GT, Markmann J, Bonner-Weir S, Weir GC. Birth and death of human ß-cells in pancreases from cadaver donors, autopsies, surgical specimens, and islets transplanted into mice. Cell Transplant. 2014 Feb; 23(2):139-51. PMID: 23321263; PMCID: PMC3947859.
  47. Bonner-Weir S, Guo L, Li WC, Ouziel-Yahalom L, Lysy PA, Weir GC, Sharma A. Islet neogenesis: a possible pathway for beta-cell replenishment. Rev Diabet Stud. 2012; 9(4):407-16. PMID: 23804276; PMCID: PMC3740706.
  48. Ma M, Chiu A, Sahay G, Doloff JC, Dholakia N, Thakrar R, Cohen J, Vegas A, Chen D, Bratlie KM, Dang T, York RL, Hollister-Lock J, Weir GC, Anderson DG. Core-shell hydrogel microcapsules for improved islets encapsulation. Adv Healthc Mater. 2013 May; 2(5):667-72. PMID: 23208618; PMCID: PMC3814167.
  49. Weir GC. Cellular transplantation into lymph nodes may not be such a crazy idea. Cell Stem Cell. 2012 Nov 02; 11(5):587-8. PMID: 23122285.
    View in: PubMed
  50. Cantley J, Walters SN, Jung MH, Weinberg A, Cowley MJ, Whitworth TP, Kaplan W, Hawthorne WJ, O'Connell PJ, Weir G, Grey ST. A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis. Cell Transplant. 2013; 22(11):2147-59. PMID: 23127310.
    View in: PubMed
  51. Barkai U, Weir GC, Colton CK, Ludwig B, Bornstein SR, Brendel MD, Neufeld T, Bremer C, Leon A, Evron Y, Yavriyants K, Azarov D, Zimermann B, Maimon S, Shabtay N, Balyura M, Rozenshtein T, Vardi P, Bloch K, de Vos P, Rotem A. Enhanced oxygen supply improves islet viability in a new bioartificial pancreas. Cell Transplant. 2013; 22(8):1463-76. PMID: 23043896.
    View in: PubMed
  52. Fonseca SG, Urano F, Weir GC, Gromada J, Burcin M. Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol. 2012 Oct; 14(10):1105-12. PMID: 22983116; PMCID: PMC3589109.
  53. Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC. Subpopulations of GFP-marked mouse pancreatic ß-cells differ in size, granularity, and insulin secretion. Endocrinology. 2012 Nov; 153(11):5180-7. PMID: 22919061; PMCID: PMC3473214.
  54. Ludwig B, Rotem A, Schmid J, Weir GC, Colton CK, Brendel MD, Neufeld T, Block NL, Yavriyants K, Steffen A, Ludwig S, Chavakis T, Reichel A, Azarov D, Zimermann B, Maimon S, Balyura M, Rozenshtein T, Shabtay N, Vardi P, Bloch K, de Vos P, Schally AV, Bornstein SR, Barkai U. Improvement of islet function in a bioartificial pancreas by enhanced oxygen supply and growth hormone releasing hormone agonist. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):5022-7. PMID: 22393012; PMCID: PMC3324017.
  55. Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet ß-cell replication. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3915-20. PMID: 22345561; PMCID: PMC3309788.
  56. Lysy PA, Weir GC, Bonner-Weir S. Concise review: pancreas regeneration: recent advances and perspectives. Stem Cells Transl Med. 2012 Feb; 1(2):150-9. PMID: 23197762; PMCID: PMC3659687.
  57. O'Sullivan ES, Vegas A, Anderson DG, Weir GC. Islets transplanted in immunoisolation devices: a review of the progress and the challenges that remain. Endocr Rev. 2011 Dec; 32(6):827-44. PMID: 21951347; PMCID: PMC3591674.
  58. Weir GC, Cavelti-Weder C, Bonner-Weir S. Stem cell approaches for diabetes: towards beta cell replacement. Genome Med. 2011 Sep 27; 3(9):61. PMID: 21951399; PMCID: PMC3239236.
  59. Weir GC, Bonner-Weir S. Finally! A human pancreatic ß cell line. J Clin Invest. 2011 Sep; 121(9):3395-7. PMID: 21865653; PMCID: PMC3163975.
  60. Weir GC, Bonner-Weir S. Sleeping islets and the relationship between ß-cell mass and function. Diabetes. 2011 Aug; 60(8):2018-9. PMID: 21788579; PMCID: PMC3142069.
  61. Berinstein NL, Morse M, Kaufman H, Nemunaitis JJ, Odunsi K, Chatta GS, Weir G, MacDonald L, Stanford M, Karkada M, Nigam R, Mansour M. A phase I study of the safety and immunogenicity of a therapeutic vaccine, DPX-0907 in patients with advanced-stage ovarian, breast, or prostate cancer. J Clin Oncol. 2011 May 20; 29(15_suppl):e13050. PMID: 28019867.
    View in: PubMed
  62. Johnson AS, O'Sullivan E, D'Aoust LN, Omer A, Bonner-Weir S, Fisher RJ, Weir GC, Colton CK. Quantitative assessment of islets of Langerhans encapsulated in alginate. Tissue Eng Part C Methods. 2011 Apr; 17(4):435-49. PMID: 21067465; PMCID: PMC3065730.
  63. Jermendy A, Toschi E, Aye T, Koh A, Aguayo-Mazzucato C, Sharma A, Weir GC, Sgroi D, Bonner-Weir S. Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells. Diabetologia. 2011 Mar; 54(3):594-604. PMID: 21240476; PMCID: PMC3045081.
  64. Aguayo-Mazzucato C, Koh A, El Khattabi I, Li WC, Toschi E, Jermendy A, Juhl K, Mao K, Weir GC, Sharma A, Bonner-Weir S. Mafa expression enhances glucose-responsive insulin secretion in neonatal rat beta cells. Diabetologia. 2011 Mar; 54(3):583-93. PMID: 21190012; PMCID: PMC3047400.
  65. da Silva Xavier G, Farhan H, Kim H, Caxaria S, Johnson P, Hughes S, Bugliani M, Marselli L, Marchetti P, Birzele F, Sun G, Scharfmann R, Rutter J, Siniakowicz K, Weir G, Parker H, Reimann F, Gribble FM, Rutter GA. Per-arnt-sim (PAS) domain-containing protein kinase is downregulated in human islets in type 2 diabetes and regulates glucagon secretion. Diabetologia. 2011 Apr; 54(4):819-27. PMID: 21181396; PMCID: PMC3052475.
  66. Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC, Sharma A. Beta-cell growth and regeneration: replication is only part of the story. Diabetes. 2010 Oct; 59(10):2340-8. PMID: 20876724; PMCID: PMC3279552.
  67. Mei Y, Hollister-Lock J, Bogatyrev SR, Cho SW, Weir GC, Langer R, Anderson DG. A high throughput micro-array system of polymer surfaces for the manipulation of primary pancreatic islet cells. Biomaterials. 2010 Dec; 31(34):8989-95. PMID: 20828808; PMCID: PMC3415986.
  68. Hamamoto Y, Akashi T, Inada A, Bonner-Weir S, Weir GC. Lack of evidence for recipient precursor cells replenishing ß-cells in transplanted islets. Cell Transplant. 2010; 19(12):1563-72. PMID: 20719077.
    View in: PubMed
  69. Pisania A, Papas KK, Powers DE, Rappel MJ, Omer A, Bonner-Weir S, Weir GC, Colton CK. Enumeration of islets by nuclei counting and light microscopic analysis. Lab Invest. 2010 Nov; 90(11):1676-86. PMID: 20697375; PMCID: PMC2966546.
  70. Pisania A, Weir GC, O'Neil JJ, Omer A, Tchipashvili V, Lei J, Colton CK, Bonner-Weir S. Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest. 2010 Nov; 90(11):1661-75. PMID: 20697378; PMCID: PMC2966538.
  71. Marselli L, Thorne J, Dahiya S, Sgroi DC, Sharma A, Bonner-Weir S, Marchetti P, Weir GC. Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One. 2010 Jul 13; 5(7):e11499. PMID: 20644627; PMCID: PMC2903480.
  72. Weir GC, Bonner-Weir S. Dreams for type 1 diabetes: shutting off autoimmunity and stimulating beta-cell regeneration. Endocrinology. 2010 Jul; 151(7):2971-3. PMID: 20570953.
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  73. Kennedy J, Katsuta H, Jung MH, Marselli L, Goldfine AB, Balis UJ, Sgroi D, Bonner-Weir S, Weir GC. Protective unfolded protein response in human pancreatic beta cells transplanted into mice. PLoS One. 2010 Jun 18; 5(6):e11211. PMID: 20585452; PMCID: PMC2887848.
  74. Igoillo-Esteve M, Marselli L, Cunha DA, Ladrière L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, Cnop M. Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia. 2010 Jul; 53(7):1395-405. PMID: 20369226.
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  75. Papas KK, Colton CK, Qipo A, Wu H, Nelson RA, Hering BJ, Weir GC, Koulmanda M. Prediction of marginal mass required for successful islet transplantation. J Invest Surg. 2010 Feb; 23(1):28-34. PMID: 20233002; PMCID: PMC3786417.
  76. O'Sullivan ES, Johnson AS, Omer A, Hollister-Lock J, Bonner-Weir S, Colton CK, Weir GC. Rat islet cell aggregates are superior to islets for transplantation in microcapsules. Diabetologia. 2010 May; 53(5):937-945. PMID: 20101386; PMCID: PMC4327903.
  77. Halban PA, German MS, Kahn SE, Weir GC. Current status of islet cell replacement and regeneration therapy. J Clin Endocrinol Metab. 2010 Mar; 95(3):1034-43. PMID: 20061422; PMCID: PMC2841538.
  78. Kushner JA, Weir GC, Bonner-Weir S. Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab. 2010 Jan; 11(1):2-3. PMID: 20085728; PMCID: PMC3762572.
  79. Weir GC, Marselli L, Marchetti P, Katsuta H, Jung MH, Bonner-Weir S. Towards better understanding of the contributions of overwork and glucotoxicity to the beta-cell inadequacy of type 2 diabetes. Diabetes Obes Metab. 2009 Nov; 11 Suppl 4:82-90. PMID: 19817791.
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  80. Katsuta H, Akashi T, Katsuta R, Nagaya M, Kim D, Arinobu Y, Hara M, Bonner-Weir S, Sharma AJ, Akashi K, Weir GC. Single pancreatic beta cells co-express multiple islet hormone genes in mice. Diabetologia. 2010 Jan; 53(1):128-38. PMID: 19851748.
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  81. Medarova Z, Vallabhajosyula P, Tena A, Evgenov N, Pantazopoulos P, Tchipashvili V, Weir G, Sachs D, Moore A. In vivo imaging of autologous islet grafts in the liver and under the kidney capsule in non-human primates. Transplantation. 2009 Jun 15; 87(11):1659-66. PMID: 19502957; PMCID: PMC2746764.
  82. Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90. PMID: 19407223; PMCID: PMC2718751.
  83. Weir GC, Koulamnda M. Control of inflammation with alpha1-antitrypsin: a potential treatment for islet transplantation and new-onset type 1 diabetes. Curr Diab Rep. 2009 Apr; 9(2):100-2. PMID: 19323953.
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  84. Kikugawa R, Katsuta H, Akashi T, Yatoh S, Weir GC, Sharma A, Bonner-Weir S. Differentiation of COPAS-sorted non-endocrine pancreatic cells into insulin-positive cells in the mouse. Diabetologia. 2009 Apr; 52(4):645-52. PMID: 19183938; PMCID: PMC4336153.
  85. Nagaya M, Katsuta H, Kaneto H, Bonner-Weir S, Weir GC. Adult mouse intrahepatic biliary epithelial cells induced in vitro to become insulin-producing cells. J Endocrinol. 2009 Apr; 201(1):37-47. PMID: 19168505.
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  86. Marselli L, Sgroi DC, Bonner-Weir S, Weir GC. Laser capture microdissection of human pancreatic beta-cells and RNA preparation for gene expression profiling. Methods Mol Biol. 2009; 560:87-98. PMID: 19504246.
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  87. O'Rahilly S, Weir GC, Matthews DR. An appreciation of Robert Turner. Diabetes. 2008 Nov; 57(11):2918-21. PMID: 18971441; PMCID: PMC2570386.
  88. Akashi T, Shigematsu H, Hamamoto Y, Iwasaki H, Yatoh S, Bonner-Weir S, Akashi K, Weir GC. Bone marrow or foetal liver cells fail to induce islet regeneration in diabetic Akita mice. Diabetes Metab Res Rev. 2008 Oct; 24(7):585-90. PMID: 18727153.
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  89. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science. 2008 Nov 07; 322(5903):945-9. PMID: 18818365; PMCID: PMC3987909.
  90. Xu J, Han J, Long YS, Lock J, Weir GC, Epstein PN, Liu YQ. Malic enzyme is present in mouse islets and modulates insulin secretion. Diabetologia. 2008 Dec; 51(12):2281-9. PMID: 18802677; PMCID: PMC2777632.
  91. Isshiki K, He Z, Maeno Y, Ma RC, Yasuda Y, Kuroki T, White GS, Patti ME, Weir GC, King GL. Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells. Kidney Int. 2008 Dec; 74(11):1434-43. PMID: 19008912; PMCID: PMC2644821.
  92. Böni-Schnetzler M, Thorne J, Parnaud G, Marselli L, Ehses JA, Kerr-Conte J, Pattou F, Halban PA, Weir GC, Donath MY. Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab. 2008 Oct; 93(10):4065-74. PMID: 18664535; PMCID: PMC2579638.
  93. Inada A, Kanamori H, Arai H, Akashi T, Araki M, Weir GC, Fukatsu A. A model for diabetic nephropathy: advantages of the inducible cAMP early repressor transgenic mouse over the streptozotocin-induced diabetic mouse. J Cell Physiol. 2008 May; 215(2):383-91. PMID: 18270980.
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  94. Tonomura N, Shimizu A, Wang S, Yamada K, Tchipashvili V, Weir GC, Yang YG. Pig islet xenograft rejection in a mouse model with an established human immune system. Xenotransplantation. 2008 Mar-Apr; 15(2):129-35. PMID: 18447886.
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  95. Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab. 2008 Mar; 93(3):1046-53. PMID: 18073315; PMCID: PMC2266961.
  96. Papas KK, Pisania A, Wu H, Weir GC, Colton CK. A stirred microchamber for oxygen consumption rate measurements with pancreatic islets. Biotechnol Bioeng. 2007 Dec 01; 98(5):1071-82. PMID: 17497731; PMCID: PMC2859188.
  97. Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia. 2007 Dec; 50(12):2486-94. PMID: 17906960.
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  98. Laybutt DR, Hawkins YC, Lock J, Lebet J, Sharma A, Bonner-Weir S, Weir GC. Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia. 2007 Oct; 50(10):2117-25. PMID: 17641871.
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  99. King AJ, Fernandes JR, Hollister-Lock J, Nienaber CE, Bonner-Weir S, Weir GC. Normal relationship of beta- and non-beta-cells not needed for successful islet transplantation. Diabetes. 2007 Sep; 56(9):2312-8. PMID: 17563059.
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  100. Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S. Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 2007 Jul; 56(7):1802-9. PMID: 17473224.
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  101. Arikawa E, Ma RC, Isshiki K, Luptak I, He Z, Yasuda Y, Maeno Y, Patti ME, Weir GC, Harris RA, Zammit VA, Tian R, King GL. Effects of insulin replacements, inhibitors of angiotensin, and PKCbeta's actions to normalize cardiac gene expression and fuel metabolism in diabetic rats. Diabetes. 2007 May; 56(5):1410-20. PMID: 17363743.
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  102. Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Weir GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007 Jun; 56(6):1551-8. PMID: 17360984.
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  103. Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GC. NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev. 2007 Mar; 23(3):239-49. PMID: 16921545.
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  104. Papas KK, Colton CK, Nelson RA, Rozak PR, Avgoustiniatos ES, Scott WE, Wildey GM, Pisania A, Weir GC, Hering BJ. Human islet oxygen consumption rate and DNA measurements predict diabetes reversal in nude mice. Am J Transplant. 2007 Mar; 7(3):707-13. PMID: 17229069; PMCID: PMC2857994.
  105. Weir GC, Bonner-Weir S. A dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest. 2007 Jan; 117(1):81-3. PMID: 17200709; PMCID: PMC1716221.
  106. Ahn YB, Xu G, Marselli L, Toschi E, Sharma A, Bonner-Weir S, Sgroi DC, Weir GC. Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection. Diabetologia. 2007 Feb; 50(2):334-42. PMID: 17180350.
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  107. López-Avalos MD, Duvivier-Kali VF, Xu G, Bonner-Weir S, Sharma A, Weir GC. Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes. 2006 May; 55(5):1223-31. PMID: 16644676.
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  108. Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure? Am J Transplant. 2006 Apr; 6(4):687-96. PMID: 16539625; PMCID: PMC3779922.
  109. Xu G, Kaneto H, Lopez-Avalos MD, Weir GC, Bonner-Weir S. GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract. 2006 Jul; 73(1):107-10. PMID: 16406191.
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  110. Fukui K, Yang Q, Cao Y, Takahashi N, Hatakeyama H, Wang H, Wada J, Zhang Y, Marselli L, Nammo T, Yoneda K, Onishi M, Higashiyama S, Matsuzawa Y, Gonzalez FJ, Weir GC, Kasai H, Shimomura I, Miyagawa J, Wollheim CB, Yamagata K. The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab. 2005 Dec; 2(6):373-84. PMID: 16330323.
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  111. Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. J Biol Chem. 2006 Jan 13; 281(2):1159-68. PMID: 16272563.
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  112. Papas KK, Avgoustiniatos ES, Tempelman LA, Weir GC, Colton CK, Pisania A, Rappel MJ, Friberg AS, Bauer AC, Hering BJ. High-density culture of human islets on top of silicone rubber membranes. Transplant Proc. 2005 Oct; 37(8):3412-4. PMID: 16298611.
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  113. King A, Lock J, Xu G, Bonner-Weir S, Weir GC. Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment. Diabetologia. 2005 Oct; 48(10):2074-9. PMID: 16132945.
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  114. Inada A, Nagai K, Arai H, Miyazaki J, Nomura K, Kanamori H, Toyokuni S, Yamada Y, Bonner-Weir S, Weir GC, Fukatsu A, Seino Y. Establishment of a diabetic mouse model with progressive diabetic nephropathy. Am J Pathol. 2005 Aug; 167(2):327-36. PMID: 16049320; PMCID: PMC1603579.
  115. Bonner-Weir S, Weir GC. New sources of pancreatic beta-cells. Nat Biotechnol. 2005 Jul; 23(7):857-61. PMID: 16003374.
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  116. Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB. The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7297-302. PMID: 15883383; PMCID: PMC1091752.
  117. Gaglia JL, Shapiro AM, Weir GC. Islet transplantation: progress and challenge. Arch Med Res. 2005 May-Jun; 36(3):273-80. PMID: 15925017.
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  118. Inada A, Weir GC, Bonner-Weir S. Induced ICER Igamma down-regulates cyclin A expression and cell proliferation in insulin-producing beta cells. Biochem Biophys Res Commun. 2005 Apr 15; 329(3):925-9. PMID: 15752744.
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  119. Iype T, Francis J, Garmey JC, Schisler JC, Nesher R, Weir GC, Becker TC, Newgard CB, Griffen SC, Mirmira RG. Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem. 2005 Apr 29; 280(17):16798-807. PMID: 15743769.
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  120. Omer A, Duvivier-Kali V, Fernandes J, Tchipashvili V, Colton CK, Weir GC. Long-term normoglycemia in rats receiving transplants with encapsulated islets. Transplantation. 2005 Jan 15; 79(1):52-8. PMID: 15714169.
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  121. Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004 Dec; 53 Suppl 3:S16-21. PMID: 15561905.
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  122. Duvivier-Kali VF, Omer A, Lopez-Avalos MD, O'Neil JJ, Weir GC. Survival of microencapsulated adult pig islets in mice in spite of an antibody response. Am J Transplant. 2004 Dec; 4(12):1991-2000. PMID: 15575901.
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  123. Fernandes JR, Duvivier-Kali VF, Keegan M, Hollister-Lock J, Omer A, Su S, Bonner-Weir S, Feng S, Lee JS, Mulligan RC, Weir GC. Transplantation of islets transduced with CTLA4-Ig and TGFbeta using adenovirus and lentivirus vectors. Transpl Immunol. 2004 Nov; 13(3):191-200. PMID: 15381202.
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  124. Weir GC, Bonner-Weir S. Beta-cell precursors--a work in progress. Nat Biotechnol. 2004 Sep; 22(9):1095-6. PMID: 15340475.
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  125. Weir GC. Can we make surrogate beta-cells better than the original? Semin Cell Dev Biol. 2004 Jun; 15(3):347-57. PMID: 15125898.
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  126. Ko SH, Suh SH, Kim BJ, Ahn YB, Song KH, Yoo SJ, Son HS, Cha BY, Lee KW, Son HY, Kang SK, Bonner-Weir S, Weir GC, Yoon KH, Park CG. Expression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells. Pancreas. 2004 Mar; 28(2):121-8. PMID: 15028943.
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  127. Omer A, Duvivier-Kali VF, Aschenbach W, Tchipashvili V, Goodyear LJ, Weir GC. Exercise induces hypoglycemia in rats with islet transplantation. Diabetes. 2004 Feb; 53(2):360-5. PMID: 14747286.
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  128. Fernandes J, Duvivier-Kali VF, Keegan M, Hollister-Loc k J, Omer A, Su S, Bonner-Weir S, Feng S, Lee J-S, Mulligan RC, Weir GC. Transplantation of Islets Transduced with CTLA4-Ig and TGFb Using Adenovirus and Lentivirus Vectors. Transplant Immunology. 2004; 13:191-200.
  129. Makhlouf L, Duvivier-Kali VF, Bonner-Weir S, Dieperink H, Weir GC, Sayegh MH. Importance of hyperglycemia on the primary function of allogeneic islet transplants. Transplantation. 2003 Aug 27; 76(4):657-64. PMID: 12973104.
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  130. Noguchi H, Kaneto H, Weir GC, Bonner-Weir S. PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes. 2003 Jul; 52(7):1732-7. PMID: 12829640.
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  131. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83. PMID: 12852853.
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  132. Omer A, Keegan M, Czismadia E, De Vos P, Van Rooijen N, Bonner-Weir S, Weir GC. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation. 2003 May; 10(3):240-51. PMID: 12694544.
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  133. Patané G, Kaneto H, Toschi E, Sharma A, Gupta S, Weir GC. Induction of Mad expression leads to augmentation of insulin gene transcription. Biochem Biophys Res Commun. 2003 Apr 18; 303(4):1199-208. PMID: 12684063.
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  134. Tatarkiewicz K, López-Avalos MD, Yoon KH, Trivedi N, Quickel RR, Bonner-Weir S, Weir GC. Development and retroviral transduction of porcine neonatal pancreatic islet cells in monolayer culture. Dev Growth Differ. 2003 Feb; 45(1):39-50. PMID: 12630945.
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  135. Omer A, Duvivier-Kali VF, Trivedi N, Wilmot K, Bonner-Weir S, Weir GC. Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice. Diabetes. 2003 Jan; 52(1):69-75. PMID: 12502495.
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  136. Makhlouf L, Duvivier-Kali V, Bonner-Weir S, Weir, GC, Sayegh MH. Importance of glycemic control on the primary function of islet transplants. Transplantation. 2003; 76:657-664.
  137. Patane G, Kaneto H, Toschi E, Sharma A, Gupta S, Weir G. Induction of Mad expression leads to augmentation of insulin gene expression. Biochem, Biophys. Res. Com. 2003; 303:1199-1208.
  138. Laybutt DR, Glandt M, Xu G, Ahn YB, Trivedi N, Bonner-Weir S, Weir GC. Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem. 2003 Jan 31; 278(5):2997-3005. PMID: 12438314.
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  139. Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes. 2002 Jun; 51(6):1793-804. PMID: 12031967.
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  140. Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC. Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem. 2002 Aug 16; 277(33):30010-8. PMID: 12011047.
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  141. Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes. 2002 Feb; 51(2):413-23. PMID: 11812749.
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  142. Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem. 2002 Apr 12; 277(15):12998-3006. PMID: 11799123.
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  143. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem. 2002 Mar 29; 277(13):10912-21. PMID: 11782487.
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  144. Matarazzo M, Giardina MG, Guardasole V, Davalli AM, Horton ES, Weir GC, Saccà L, Napoli R. Islet transplantation under the kidney capsule corrects the defects in glycogen metabolism in both liver and muscle of streptozocin-diabetic rats. Cell Transplant. 2002; 11(2):103-12. PMID: 12099634.
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  145. Bühler L, Deng S, O'Neil J, Kitamura H, Koulmanda M, Baldi A, Rahier J, Alwayn IP, Appel JZ, Awwad M, Sachs DH, Weir G, Squifflet JP, Cooper DK, Morel P. Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD154 blockade. Xenotransplantation. 2002 Jan; 9(1):3-13. PMID: 12005102.
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  146. Laviola L, Belsanti G, Davalli AM, Napoli R, Perrini S, Weir GC, Giorgino R, Giorgino F. Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart. Diabetes. 2001 Dec; 50(12):2709-20. PMID: 11723053.
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  147. Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GC. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 01; 277(5):3680-5. PMID: 11714718.
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  148. Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MA, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GC. NMR spectroscopy in beta cell engineering and islet transplantation. Ann N Y Acad Sci. 2001 Nov; 944:96-119. PMID: 11797699.
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  149. Duvivier-Kali VF, Omer A, Parent RJ, O'Neil JJ, Weir GC. Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane. Diabetes. 2001 Aug; 50(8):1698-705. PMID: 11473027.
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  150. Jonas JC, Laybutt DR, Steil GM, Trivedi N, Pertusa JG, Van de Casteele M, Weir GC, Henquin JC. High glucose stimulates early response gene c-Myc expression in rat pancreatic beta cells. J Biol Chem. 2001 Sep 21; 276(38):35375-81. PMID: 11457846.
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  151. Tatarkiewicz K, Garcia M, Lopez-Avalos M, Bonner-Weir S, Weir GC. Porcine neonatal pancreatic cell clusters in tissue culture: benefits of serum and immobilization in alginate hydrogel. Transplantation. 2001 Jun 15; 71(11):1518-26. PMID: 11435959.
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  152. Kaneto H, Xu G, Song KH, Suzuma K, Bonner-Weir S, Sharma A, Weir GC. Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem. 2001 Aug 17; 276(33):31099-104. PMID: 11390407.
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  153. Tatarkiewicz K, Garcia M, Omer A, Van Schilfgaarde R, Weir GC, De Vos P. C-peptide responses after meal challenge in mice transplanted with microencapsulated rat islets. Diabetologia. 2001 May; 44(5):646-53. PMID: 11380084.
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  154. Steil GM, Trivedi N, Jonas JC, Hasenkamp WM, Sharma A, Bonner-Weir S, Weir GC. Adaptation of beta-cell mass to substrate oversupply: enhanced function with normal gene expression. Am J Physiol Endocrinol Metab. 2001 May; 280(5):E788-96. PMID: 11287362.
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  155. Trivedi N, Hollister-Lock J, Lopez-Avalos MD, O'Neil JJ, Keegan M, Bonner-Weir S, Weir GC. Increase in beta-cell mass in transplanted porcine neonatal pancreatic cell clusters is due to proliferation of beta-cells and differentiation of duct cells. Endocrinology. 2001 May; 142(5):2115-22. PMID: 11316779.
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  156. Trivedi N, Hollister-Lock J, Lopez-Avalos MD, O'Neil JJ, Keegan M, Bonner-Weir S, Weir GC. Increase in ß-Cell Mass in Transplanted Porcine Neonatal Pancreatic Cell Clusters Is Due to Proliferation of ß-Cells and Differentiation of Duct Cells. Endocrinology. 2001 May 01; 142(5):2115-2122. PMID: 28201207.
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  157. Lopez-Avalos MD, Tatarkiewicz K, Sharma A, Bonner-Weir S, Weir GC. Enhanced maturation of porcine neonatal pancreatic cell clusters with growth factors fails to improve transplantation outcome. Transplantation. 2001 Apr 27; 71(8):1154-62. PMID: 11374418.
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  158. Vasir B, Jonas JC, Steil GM, Hollister-Lock J, Hasenkamp W, Sharma A, Bonner-Weir S, Weir GC. Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets. Transplantation. 2001 Apr 15; 71(7):924-35. PMID: 11349728.
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  159. Laybutt R, Hasenkamp W, Groff A, Grey S, Jonas JC, Kaneto H, Sharma A, Bonner-Weir S, Weir G. beta-cell adaptation to hyperglycemia. Diabetes. 2001 Feb; 50 Suppl 1:S180-1. PMID: 11272186.
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  160. Weir GC, Laybutt DR, Kaneto H, Bonner-Weir S, Sharma A. Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes. 2001 Feb; 50 Suppl 1:S154-9. PMID: 11272180.
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  161. Jonas JC, Laybutt R, Steil GM, Trivedi N, Weir GC, Henquin JC. Potential role of the early response gene c-myc in beta-cell adaptation to changes in glucose concentration. Diabetes. 2001 Feb; 50 Suppl 1:S137. PMID: 11272174.
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  162. Trivedi N, Keegan M, Steil GM, Hollister-Lock J, Hasenkamp WM, Colton CK, Bonner-Weir S, Weir GC. Islets in alginate macrobeads reverse diabetes despite minimal acute insulin secretory responses. Transplantation. 2001 Jan 27; 71(2):203-11. PMID: 11213060.
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  163. Lopez-Avalos MD, Tatarkiewicz K, Sharma A, Bonner-Weir S and Weir GC. Optimization of the culture of porcine neonatal pancreatic cell clusters intended for transplantation . Transplantation. 2001; 71:1154-1162.
  164. Papas KK, Colton CK, Gounarides JS, Roos ES, Jarema MAC, Shapiro MJ, Cheng LL, Cline GW, Shulman GI, Wu H, Bonner-Weir S, Weir GC . NMR spectroscopy in beta cell engineering and islet transplntation. Bioartificial Organs III: Tissue Sourcing, Immunoisolation and Clinical Trials . Ann NY Acad of Sciences. 2001; 944:96-119.
  165. Trivedi N, Hollister-Lock J, Lopez-Avalos MD, O'Neil JJ, Keegan M, Bonner- Weir S, Weir GC. Increase in b-cell mass after transplantation of porcine neonatal pancreatic cell clusters is due to proliferation of b- cells and differentiation of duct cells. Endocrinology. 2001; 142:2115-2122.
  166. Steil GM, Trivedi N, Jonas J-C, Hasenkamp WM, Sharma A, Bonner-Weir S, Weir GC. Enhanced beta-cell function with normal islet gene expression following adaptation of b-cell mass to substrate oversupply. Am J Physiol Endoc Metab. 2001; 280:E788-E796.
  167. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A. 2000 Jul 05; 97(14):7999-8004. PMID: 10884429; PMCID: PMC16659.
  168. Vasir B, Reitz P, Xu G, Sharma A, Bonner-Weir S, Weir GC. Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-alpha, TGF-beta, bFGF and Vimentin) in cultured and transplanted rat islets. Diabetologia. 2000 Jun; 43(6):763-72. PMID: 10907122.
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  169. de Souza CJ, Capotorto JV, Cornell-Kennon S, Wu YJ, Steil GM, Trivedi N, Weir GC. Beta-cell dysfunction in 48-hour glucose-infused rats is not a consequence of elevated plasma lipid or islet triglyceride levels. Metabolism. 2000 Jun; 49(6):755-9. PMID: 10877202.
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  170. Vasir B, Reitz P, Xu Gang, Sharma A, Bonner-Weir S, Weir GC. Diabetic state delays gene expression of markers of angiogenesis HGF, uPA and uPAR in transplanted islets. Diabetologia. 2000; 43:763-772.
  171. Trivedi N, Steil GM, Colton CK, Bonner-Weir S, Weir GC. Improved vascularization of planar membrane diffusion devices following continuous infusion of vascular endothelial growth factor. Cell Transplant. 2000 Jan-Feb; 9(1):115-24. PMID: 10784073.
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  172. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz, Song K-H, Sharma A, O’Neil J. In vitro cultivation of human islets from expanded ductal tissue . PNAS. 2000; 97:7999-8004.
  173. Yoon KH, Quickel RR, Tatarkiewicz K, Ulrich TR, Hollister-Lock J, Trivedi N, Bonner-Weir S, Weir GC. Differentiation and expansion of beta cell mass in porcine neonatal pancreatic cell clusters transplanted into nude mice. Cell Transplant. 1999 Nov-Dec; 8(6):673-89. PMID: 10701496.
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  175. Feng S, Quickel RR, Hollister-Lock J, McLeod M, Bonner-Weir S, Mulligan RC, Weir GC. Prolonged xenograft survival of islets infected with small doses of adenovirus expressing CTLA4Ig. Transplantation. 1999 Jun 27; 67(12):1607-13. PMID: 10401769.
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  176. Wu H, Avgoustiniatos ES, Swette L, Bonner-Weir S, Weir GC, Colton CK. In situ electrochemical oxygen generation with an immunoisolation device. Ann N Y Acad Sci. 1999 Jun 18; 875:105-25. PMID: 10415561.
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  177. Jonas JC, Sharma A, Hasenkamp W, Ilkova H, Patanè G, Laybutt R, Bonner-Weir S, Weir GC. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes. J Biol Chem. 1999 May 14; 274(20):14112-21. PMID: 10318828.
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  178. Finegood DT, Weir GC, Bonner-Weir S. Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats. Am J Physiol. 1999 May; 276(5 Pt 1):E822-7. PMID: 10329974.
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  179. Lee B, Jonas JC, Weir GC, Laychock SG. Glucose regulates expression of inositol 1,4,5-trisphosphate receptor isoforms in isolated rat pancreatic islets. Endocrinology. 1999 May; 140(5):2173-82. PMID: 10218969.
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  180. Giorgino F, Logoluso F, Davalli AM, Napoli R, Laviola L, Hirshman MF, Horton ES, Weir GC, Smith RJ. Islet transplantation restores normal levels of insulin receptor and substrate tyrosine phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle and myocardium of streptozocin-induced diabetic rats. Diabetes. 1999 Apr; 48(4):801-12. PMID: 10102697.
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  181. Tatarkiewicz K, Hollister-Lock J, Quickel RR, Colton CK, Bonner-Weir S, Weir GC. Reversal of hyperglycemia in mice after subcutaneous transplantation of macroencapsulated islets. Transplantation. 1999 Mar 15; 67(5):665-71. PMID: 10096520.
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  182. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999 Mar; 48(3):507-13. PMID: 10078550.
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  183. Weitgasser R, Davalli AM, Weir GC. Measurement of glucose concentrations in rats: differences between glucose meter and plasma laboratory results. Diabetologia. 1999 Feb; 42(2):256. PMID: 10064108.
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  184. Suzuki K, Colton CK, Bonner-Weir S, Hollister J, Weir GC. Estimating number and volume of islets transplanted within a planar immunobarrier diffusion chamber. Methods Mol Med. 1999; 18:497-505. PMID: 21370199.
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  185. Wu H, Avgoustiniatos ES, Swette L, Bonner-Weir S, Weir GC, Colton CK. In situ electrochemical oxygen generation with an immunoisolation device. New York Acad Science. 1999; 875:105-125.
  186. Vasir B, Aiello LP, Yoon KH, Quickel RR, Bonner-Weir S, Weir GC. Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells. Diabetes. 1998 Dec; 47(12):1894-903. PMID: 9836521.
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  187. Weir GC, Bonner-Weir S. Islet transplantation as a treatment for diabetes. J Am Optom Assoc. 1998 Nov; 69(11):727-32. PMID: 9844324.
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  188. Suzuki K, Bonner-Weir S, Trivedi N, Yoon KH, Hollister-Lock J, Colton CK, Weir GC. Function and survival of macroencapsulated syngeneic islets transplanted into streptozocin-diabetic mice. Transplantation. 1998 Jul 15; 66(1):21-8. PMID: 9679817.
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  189. Seufert J, Weir GC, Habener JF. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus. J Clin Invest. 1998 Jun 01; 101(11):2528-39. PMID: 9616224; PMCID: PMC508842.
  190. Tatarkiewicz K, Hollister-Lock J, Quickel RR, Cotton CK, Bonner-Weir S, Weir GC. Subcutaneous transplantation of rat islets into diabetic nude. Transplant Proc. 1998 Mar; 30(2):479-80. PMID: 9532136.
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  191. Yoon KH, Quickel RR, Tatarkiewicz K, Weir GC, Bonner-Weir S. Growth and differentiation of transplanted porcine neonatal pancreatic cell clusters in normal nude mice. Transplant Proc. 1998 Mar; 30(2):601. PMID: 9532194.
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  192. Suzuki K, Bonner-Weir S, Hollister-Lock J, Colton CK, Weir GC. Number and volume of islets transplanted in immunobarrier devices. Cell Transplant. 1998 Jan-Feb; 7(1):47-52. PMID: 9489762.
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  193. Seufert JR, Weir GC, Habener JF. Differential expression of the insulin gene transcriptional repressor C/EBPbeta and transactivatior IDX-1 in rat pancreatic beta cells during the development of diabetes mellitus. J Clin Invest. 1998; 101:2528-2539.
  194. Vasir B, Aiello LP, Yoon K-H, Quickel RR, Bonner-Weir S, Weir GC. Hypoxia induced VEGF gene and protein expression in rat islets. Diabetes. 1998; 47:1894-1903.
  195. Björklund A, Yaney G, McGarry JD, Weir G. Fatty acids and beta-cell function. Diabetologia. 1997 Oct; 40 Suppl 3:B21-6. PMID: 9345641.
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  196. Weir GC, Sharma A, Zangen DH, Bonner-Weir S. Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis. Acta Diabetol. 1997 Oct; 34(3):177-84. PMID: 9401638.
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  197. Weir GC, Bonner-Weir S. Scientific and political impediments to successful islet transplantation. Diabetes. 1997 Aug; 46(8):1247-56. PMID: 9231647.
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  198. Trivedi N, Suzuki K, Bonner-Weir S, Hollister-Lock J, Weir GC. Islet number in an immunobarrier device required to treat diabetes in mice. Transplant Proc. 1997 Jun; 29(4):2142-3. PMID: 9193561.
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  199. Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC. Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy. Diabetes. 1997 Feb; 46(2):258-64. PMID: 9000703.
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  200. Montaña E, Bonner-Weir S, Weir GC. Beta cell replication and mass in islet transplantation. Adv Exp Med Biol. 1997; 426:421-7. PMID: 9580368.
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  201. Weir GC, Quickel RR, Yoon KH, Tatarkiewicz K, Ulrich TR, Hollister-Lock J, Bonner-Weir S. Porcine neonatal pancreatic cell clusters (NPCCs): a potential source of tissue for islet transplantation. Ann Transplant. 1997; 2(3):63-8. PMID: 9869866.
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  202. Suzuki K, Bonner-Weir S, Hollister J, Weir GC. A method for estimating number and mass of islets transplanted within a membrane device. Cell Transplant. 1996 Nov-Dec; 5(6):613-25. PMID: 8951219.
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  203. Kieffer TJ, Heller RS, Unson CG, Weir GC, Habener JF. Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets. Endocrinology. 1996 Nov; 137(11):5119-25. PMID: 8895386.
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  204. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes. 1996 Sep; 45(9):1161-7. PMID: 8772716.
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  205. Lipes MA, Cooper EM, Skelly R, Rhodes CJ, Boschetti E, Weir GC, Davalli AM. Insulin-secreting non-islet cells are resistant to autoimmune destruction. Proc Natl Acad Sci U S A. 1996 Aug 06; 93(16):8595-600. PMID: 8710916; PMCID: PMC38718.
  206. Davalli AM, Napoli R, Weitgasser R, Capotorto JV, Hirshman MF, Finegood DT, Bonner-Weir S, Horton ES, Weir GC. Long-term normalization of GLUT-4 protein content in skeletal muscle of diabetic rats following islet transplantation. J Endocrinol. 1996 Aug; 150(2):255-63. PMID: 8869592.
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  207. Juang JH, Bonner-Weir S, Ogawa Y, Vacanti JP, Weir GC. Outcome of subcutaneous islet transplantation improved by polymer device. Transplantation. 1996 Jun 15; 61(11):1557-61. PMID: 8669096.
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  208. Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE. Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3492-6. PMID: 8622964; PMCID: PMC39637.
  209. Noma Y, Bonner-Weir S, Latimer JB, Davalli AM, Weir GC. Translocation of glucokinase in pancreatic beta-cells during acute and chronic hyperglycemia. Endocrinology. 1996 Apr; 137(4):1485-91. PMID: 8625927.
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  210. Napoli R, Davalli AM, Hirshman MF, Weitgasser R, Weir GC, Horton ES. Islet transplantation under the kidney capsule fully corrects the impaired skeletal muscle glucose transport system of streptozocin diabetic rats. J Clin Invest. 1996 Mar 15; 97(6):1389-97. PMID: 8617870; PMCID: PMC507197.
  211. Weitgasser R, Davalli AM, Capotorto JV, Finegood DT, Bonner-Weir S, Weir GC. Islet transplantation in diabetic Lewis rats--a comparison of the transplantation sites kidney and spleen capsule. Acta Med Austriaca. 1996; 23(5):156-9. PMID: 9082744.
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  212. Davalli AM, Napoli R, Weitgasser R, Capotorto JV, Hirshman MF, Finegood DT, Bonner-Weir S, Horton ES, Weir GC. Long-term normalization of GLUT-4 protein content in skeletal muscle of diabetic rats following islet transplantation. J Endocrinology. 1996; 150(2):255-263.
  213. Lipes MA, Cooper E, Skelly R, Rhodes CJ, Boschetti E, Weir GC, Davalli AM. . Transgenic engineering of non-islet cells for beta cell replacement in insulin dependent diabetes mellitus. Proc Natl Acad Sci USA. 1996; 93:8595-8600.
  214. Verchere CB, D'Alessio DA, Palmiter RD, Weir GC, Bonner-Weir S, Baskin DG, Kahn SE. Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci USA. 1996; 93:3492-3496.
  215. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Islet vulnerability in the immediate post-transplant period. Role exerted by the recipients metabolic control. Diabetes. 1996; 45:1161-1167.
  216. Weitgasser R, Davalli AM, Napoli R, Capotorto JV, Finegood DT, Bonner-Weir S, Weir GC. Long-term normalization of GLUT 4 protein content in skeletal muscle of streptozotocin-diabetic Lewis rats after islet transplantation. Transplant Proc. 1995 Dec; 27(6):3184-5. PMID: 8539901.
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  217. Davalli AM, Scaglia L, Zangen DH, Hollister J, Bonner-Weir S, Weir GC. Early changes in syngeneic islet grafts: effect of recipient's metabolic control on graft outcome. Transplant Proc. 1995 Dec; 27(6):3238-9. PMID: 8539932.
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  218. Juang JH, Bonner-Weir S, Vacanti JP, Weir GC. Outcome of subcutaneous islet transplantation improved by a polymer device. Transplant Proc. 1995 Dec; 27(6):3215-6. PMID: 8539921.
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  219. Weir GC. Which comes first in non-insulin-dependent diabetes mellitus: insulin resistance or beta-cell failure? Both come first. JAMA. 1995 Jun 21; 273(23):1878-9. PMID: 7776508.
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  220. Davalli AM, Ogawa Y, Ricordi C, Scharp DW, Bonner-Weir S, Weir GC. A selective decrease in the beta cell mass of human islets transplanted into diabetic nude mice. Transplantation. 1995 Mar 27; 59(6):817-20. PMID: 7701574.
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  221. Weir GC. Glucagon-like peptide-1 (GLP-1): a piece of the incretin puzzle. J Clin Invest. 1995 Jan; 95(1):1. PMID: 7814603; PMCID: PMC295354.
  222. Ogawa Y, Noma Y, Davalli AM, Wu YJ, Thorens B, Bonner-Weir S, Weir GC. Loss of glucose-induced insulin secretion and GLUT2 expression in transplanted beta-cells. Diabetes. 1995 Jan; 44(1):75-9. PMID: 7813817.
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  223. Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GC. Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes. 1995 Jan; 44(1):104-11. PMID: 7813803.
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  224. Weir GC, Nathan DM, Singer DE. Standards of care for diabetes. Diabetes Care. 1994 Dec; 17(12):1514-22. PMID: 7882829.
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  225. Juang JH, Bonner-Weir S, Wu YJ, Weir GC. Beneficial influence of glycemic control upon the growth and function of transplanted islets. Diabetes. 1994 Nov; 43(11):1334-9. PMID: 7926308.
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  226. Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GC. Porcine islet grafts in diabetic nude mice: dynamic insulin secretion and regulated B-cell mass lower glucose levels to the normal porcine range. Transplant Proc. 1994 Jun; 26(3):1098-9. PMID: 8029845.
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  227. Lorenzo A, Razzaboni B, Weir GC, Yankner BA. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature. 1994 Apr 21; 368(6473):756-60. PMID: 8152488.
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  228. Montaña E, Bonner-Weir S, Weir GC. Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass. J Clin Invest. 1994 Apr; 93(4):1577-82. PMID: 8163660; PMCID: PMC294183.
  229. Montaña E, Bonner-Weir S, Weir GC. Transplanted beta-cell replication and mass increase after 95% pancreatectomy. Transplant Proc. 1994 Apr; 26(2):657. PMID: 7909632.
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  230. Efrat S, Leiser M, Wu YJ, Fusco-DeMane D, Emran OA, Surana M, Jetton TL, Magnuson MA, Weir G, Fleischer N. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2051-5. PMID: 7510884; PMCID: PMC43307.
  231. Efrat S, Leiser M, Wu Y-J, Fusco-DeMane D, Emran OA, Sunra M, Jetton JL, Magnuson MA, Weir GC, Fleischer N. Ribozyme-mediated attentuation of pancreatic B-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. Proc Nat Acad Sci. 1994; 91:2051-2055.
  232. Klopper JM, Myers JE, Ehrlich R, McIntyre D, Chetty K, Weir G, Hoffman M, Cooper D, London L. AIDS and the social irresponsibility of the insurance industry. S Afr Med J. 1993 Sep; 83(9):690. PMID: 8310367.
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  233. Weir GC. The relationship of diabetes, loss of glucose-induced insulin secretion, and GLUT2. J Diabetes Complications. 1993 Apr-Jun; 7(2):124-9. PMID: 8518454.
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  234. Schuppin GT, Bonner-Weir S, Montana E, Kaiser N, Weir GC. Replication of adult pancreatic-beta cells cultured on bovine corneal endothelial cell extracellular matrix. In Vitro Cell Dev Biol Anim. 1993 Apr; 29A(4):339-44. PMID: 8320184.
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  235. Weir GC. A defective beta-cell glucose sensor as a cause of diabetes. N Engl J Med. 1993 Mar 11; 328(10):729-31. PMID: 8433735.
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  236. Montaña E, Bonner-Weir S, Weir GC. Beta cell mass and growth after syngeneic islet cell transplantation in normal and streptozocin diabetic C57BL/6 mice. J Clin Invest. 1993 Mar; 91(3):780-7. PMID: 8450059; PMCID: PMC288028.
  237. Schuppin GT, Bonner-Weir S, Montana E, Kaiser N, Weir G.C. Replication of adult pancreatic B-cells cultured on bovine corneal endothelial extracellular matrix. In Vitro. 1993; 29A:339-344.
  238. Hendrick GK, Gjinovci A, Baxter LA, Mojsov S, Wollheim CB, Habener JF, Weir GC. Glucagon-like peptide-I-(7-37) suppresses hyperglycemia in rats. Metabolism. 1993 Jan; 42(1):1-6. PMID: 8446036.
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  239. Montaña E, Bonner-Weir S, Weir GC. Beta-cell mass falls progressively when hyperglycemia persists after islet transplantation. Transplant Proc. 1992 Dec; 24(6):2996. PMID: 1466031.
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  240. Chen C, Thorens B, Bonner-Weir S, Weir GC, Leahy JL. Recovery of glucose-induced insulin secretion in a rat model of NIDDM is not accompanied by return of the B-cell GLUT2 glucose transporter. Diabetes. 1992 Oct; 41(10):1320-7. PMID: 1397706.
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  241. Tal M, Wu YJ, Leiser M, Surana M, Lodish H, Fleischer N, Weir G, Efrat S. [Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5744-8. PMID: 1631055; PMCID: PMC402094.
  242. Thorens B, Wu YJ, Leahy JL, Weir GC. The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment. J Clin Invest. 1992 Jul; 90(1):77-85. PMID: 1634622; PMCID: PMC443065.
  243. Leahy JL, Bonner-Weir S, Weir GC. Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. Diabetes Care. 1992 Mar; 15(3):442-55. PMID: 1559411.
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  244. Tal M, Wu Y-J, Leiser M, Surana M, Lodish H, Fleischer N, Weir G, Efrat S. . (Val 12) HRAS downregulates GLUT-2 in beta cells of transgenic mice without affecting glucose homeostasis. Proc. Natl. Acad Sci. USA. 1992; 90:77-85.
  245. Leahy JL, Weir GC. Beta-cell dysfunction in hyperglycaemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level. Diabetologia. 1991 Sep; 34(9):640-7. PMID: 1955096.
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  246. Leahy JL, Halban PA, Weir GC. Relative hypersecretion of proinsulin in rat model of NIDDM. Diabetes. 1991 Aug; 40(8):985-9. PMID: 1860563.
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  247. Smith FE, Rosen KM, Villa-Komaroff L, Weir GC, Bonner-Weir S. Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6152-6. PMID: 1712481; PMCID: PMC52040.
  248. Smith FE, Rosen KM, Villa-Komaroff L, Weir GC. Bonner-Weir S. Enhanced insulin-like growth factor I gene expression in regenerating rat pancreas. Proc Natl. Acad Sci USA. 1991; 88:6152-6156.
  249. Leahy JL, Halban PA, Weir GC. Relative hypersection of proinsulin in rat model of NIDDM. Diabetes. 1991; 40:985-989.
  250. Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir S. Reduced expression of the liver/beta-cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6492-6. PMID: 2204056; PMCID: PMC54562.
  251. Weir GC, Bonner-Weir S, Leahy JL. Islet mass and function in diabetes and transplantation. Diabetes. 1990 Apr; 39(4):401-5. PMID: 2108068.
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  252. Gefel D, Hendrick GK, Mojsov S, Habener J, Weir GC. Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation. Endocrinology. 1990 Apr; 126(4):2164-8. PMID: 2156683.
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  253. Weir GC, Bonner-Weir S. Islets of Langerhans: the puzzle of intraislet interactions and their relevance to diabetes. J Clin Invest. 1990 Apr; 85(4):983-7. PMID: 1969425; PMCID: PMC296525.
  254. Thorens B, Weir GC, Leahy JL, Lodish HF, Bonner-Weir S. Reduced expression of the liver/beta cell glucose transporter isoform in glucose-insensitive pancreatic beta cells of diabetic rats. Proc. Natl. Acad Sci. 1990; 87:6492-6494.
  255. Gross DJ, Villa-Komaroff L, Kahn CR, Weir GC, Halban PA. Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells. J Biol Chem. 1989 Dec 25; 264(36):21486-90. PMID: 2689438.
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  256. Gross DJ, Halban PA, Kahn CR, Weir GC, Villa-Komaroff L. Partial diversion of a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells. Proc Natl Acad Sci U S A. 1989 Jun; 86(11):4107-11. PMID: 2657740; PMCID: PMC287398.
  257. Lee HC, Bonner-Weir S, Weir GC, Leahy JL. Compensatory adaption to partial pancreatectomy in the rat. Endocrinology. 1989 Mar; 124(3):1571-5. PMID: 2645116.
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  258. Weir GC, Mojsov S, Hendrick GK, Habener JF. Glucagonlike peptide I (7-37) actions on endocrine pancreas. Diabetes. 1989 Mar; 38(3):338-42. PMID: 2645190.
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  259. Bonner-Weir S, Deery D, Leahy JL, Weir GC. Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes. 1989 Jan; 38(1):49-53. PMID: 2642434.
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  260. Weir GC, Mojsov S, Hendrick GK, Habener JF. Glucagon like Peptide-1(7-37) actions on endocrine pancreas. Diabetes. 1989; 38:338-342.
  261. Gross D.J., Halban PA, Kahn CR, Weir GC, Villa-Komaroff L. Partial diversion a mutant proinsulin (B10 aspartic acid) from the regulated to the constitutive secretory pathway in transfected AtT-20 cells. Proc. Natl. Acad.Sci USA. 1989; 86:4107-4111.
  262. Gross DJ, Villa-Komaroff L, Kahn CR, Weir GC., Halban PA . Deletion of a highly conserved tetrapeptide sequence of the proinsulin connecting peptide (C-peptide) inhibits proinsulin to insulin conversion by transfected pituitary corticotroph (AtT20) cells. J. Biol. Chem. 1989; 264:21486-21490.
  263. Gross D, Skvorak A, Hendrick G, Weir G, Villa-Komaroff L, Halban P. Oxidation of rat insulin II, but not I, leads to anomalous elution profiles upon HPLC analysis of insulin-related peptides. FEBS Lett. 1988 Dec 05; 241(1-2):205-8. PMID: 3058512.
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  264. Brockenbrough JS, Weir GC, Korc M. Alterations in EGF binding to acini during pancreatic regeneration in the rat. Int J Pancreatol. 1988 Dec; 3(6):415-24. PMID: 3065416.
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  265. Leahy JL, Bonner-Weir S, Weir GC. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy. J Clin Invest. 1988 May; 81(5):1407-14. PMID: 3284912; PMCID: PMC442571.
  266. Leahy JL, Weir GC. Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia. Diabetes. 1988 Feb; 37(2):217-22. PMID: 3292316.
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  267. Brockenbrough JS, Weir GC, Bonner-Weir S. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes. 1988 Feb; 37(2):232-6. PMID: 3292318.
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  268. Brockenbrough JS, Weir GC, Korc M. Alterations in EGF binding to acini during pancreatic regeneration in the rat. Int. J. Pancreatology. 1988; 3:415-424.
  269. Leahy JL, Samols MD, Weir GC. Effects of glyburide in a rat model of reduced B-cell mass. Prog Clin Biol Res. 1988; 265:87-98. PMID: 3136456.
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  270. Brockenbrough JS, Weir, GC, Bonner-Weir S. Discordance of exocrine and endocrine growth following 90% partial pancreatectomy in the rat. Diabetes. 1988; 37:232-236.
  271. Leahy JL, Bonner-Weir S, Weir GC. Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion following incomplete pancreatectomy in the rat. J. Clin. Invest. 1988; 77:1407-1414.
  272. Colella RM, May JM, Bonner-Weir S, Leahy JL, Weir GC. Glucose utilization in islets of hyperglycemic rat models with impaired glucose-induced insulin secretion. Metabolism. 1987 Apr; 36(4):335-7. PMID: 3550372.
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  273. Leahy JL, Cooper HE, Weir GC. Impaired insulin secretion associated with near normoglycemia. Study in normal rats with 96-h in vivo glucose infusions. Diabetes. 1987 Apr; 36(4):459-64. PMID: 3545946.
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  274. Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest. 1987 Feb; 79(2):616-9. PMID: 3543057; PMCID: PMC424143.
  275. Leahy JL, Cooper, HE, Weir GC. Impaired insulin secretion associated with nearnormoglycemia: A study in normal rats using 96 hour in vivo glucose infusions. Diabetes. 1987; 36:459-464.
  276. Wagman LD, Newsome HH, Miller KB, Thomas RB, Weir GC. The effect of acute discontinuation of total parenteral nutrition. Ann Surg. 1986 Nov; 204(5):524-9. PMID: 3094465; PMCID: PMC1251334.
  277. Leahy JL, Cooper HE, Deal DA, Weir GC. Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion. A study in normal rats using chronic in vivo glucose infusions. J Clin Invest. 1986 Mar; 77(3):908-15. PMID: 3512603; PMCID: PMC423478.
  278. Samols E, Bonner-Weir S, Weir GC. Intra-islet insulin-glucagon-somatostatin relationships. Clin Endocrinol Metab. 1986 Feb; 15(1):33-58. PMID: 2869846.
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  279. Weir GC, Leahy JL, Bonner-Weir S. Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes. Diabetes Metab Rev. 1986; 2(1-2):125-61. PMID: 2424696.
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  280. Weir GC, Leahy JL, Barras E, Braunstein LP. Characteristics of insulin and glucagon release from the perfused pancreas, intact isolated islets, and dispersed islet cells. Horm Res. 1986; 24(1):62-72. PMID: 3530935.
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  281. Wagman LD, Newsome HH, Miller KB, Thomas RB, Weir GC. Effect of acute discontinuation of total parentaeral nutrition. Ann Surger. 1986; 204:524-529.
  282. Weir GC, Leahy JL, Barras E. Braunstein LP. Characteristics of insulin and glucagon release from the perfused pancreas, intact isolated islets, and dispersed cells. Hormone Res. 1986; 24:62-72.
  283. Colella RM, Bonner-Weir S, Braunstein LP, Schwalke M, Weir GC. Pancreatic islets of variable size--insulin secretion and glucose utilization. Life Sci. 1985 Sep 16; 37(11):1059-65. PMID: 3897755.
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  284. Leahy JL, Bonner-Weir S, Weir GC. Abnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment. Diabetes. 1985 Jul; 34(7):660-6. PMID: 2408948.
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  285. Leahy JL, Weir GC. Unresponsiveness to glucose in a streptozocin model of diabetes. Inappropriate insulin and glucagon responses to a reduction of glucose concentration. Diabetes. 1985 Jul; 34(7):653-9. PMID: 2861128.
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  286. Giddings SJ, Orland MJ, Weir GC, Bonner-Weir S, Permutt MA. Impaired insulin biosynthetic capacity in a rat model for non-insulin-dependent diabetes. Studies with dexamethasone. Diabetes. 1985 Mar; 34(3):235-40. PMID: 3882490.
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  287. Weir GC, Bonner-Weir S. Pancreatic somatostatin. Adv Exp Med Biol. 1985; 188:403-23. PMID: 2863944.
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  288. Leahy JL, Bonner-Weir S, Weir GC. Abnormal glucose regulation of insulin secretion in models of reduced B-cell mass. Diabetes. 1984 Jul; 33(7):667-73. PMID: 6203798.
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  289. Trimble ER, Weir GC, Gjinovci A, Assimacopoulos-Jeannet F, Benzi R, Renold AE. Increased insulin responsiveness in vivo and in vitro consequent to induced hyperinsulinemia in the rat. Diabetes. 1984 May; 33(5):444-9. PMID: 6144606.
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  290. Permutt MA, Kakita K, Malinas P, Karl I, Bonner-Weir S, Weir G, Giddings SJ. An in vivo analysis of pancreatic protein and insulin biosynthesis in a rat model for non-insulin-dependent diabetes. J Clin Invest. 1984 May; 73(5):1344-50. PMID: 6232285; PMCID: PMC425156.
  291. Weir GC, Halban PA, Meda P, Wollheim CB, Orci L, Renold AE. Dispersed adult rat pancreatic islet cells in culture: A, B, and D cell function. Metabolism. 1984 May; 33(5):447-53. PMID: 6201694.
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  292. Trent DF, Fletcher DJ, May JM, Bonner-Weir S, Weir GC. Abnormal islet and adipocyte function in young B-cell-deficient rats with near-normoglycemia. Diabetes. 1984 Feb; 33(2):170-5. PMID: 6363171.
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  293. Weir GC, Halban PA, Meda P. Wollheim CB, Orci L. Renold AE. A functional and morphological study of dispersed adult pancreatic islet cells. Metabolism. 1984; 33:447-453.
  294. Trent DF, Schwalke MA, Weir GC. Pancreatic and gut hormones during fasting: insulin, glucagon, and somatostatin. Horm Res. 1984; 19(2):70-6. PMID: 6142854.
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  295. Permutt MA O'Connell K, Kakita K, Malinas P, Karl I, Bonner-Weir S., Weir GC. Giddings SJ. An in vitro analyses of pancreatic protein and insulin biosynthesis in a rat model for non-insulin dependent diabetes. . J Clin Invest. 1984; 73:1344-1350.
  296. Trent DF, Schwalke MA, Weir GC. Pancreatic and gut hormones during fasting; Insulin, glucagon and somatostatin. Hormone Research. 1984; 19:70-76.
  297. Fletcher DJ, Grogan WM, Barras E, Weir GC. Hormone release by islet B cell-enriched and A and D cell-enriched populations prepared by flow cytometry. Endocrinology. 1983 Nov; 113(5):1791-8. PMID: 6194980.
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  298. Rothman BS, Weir G, Dudek FE. Egg-laying hormone: direct action on the ovotestis of Aplysia. Gen Comp Endocrinol. 1983 Oct; 52(1):134-41. PMID: 6685081.
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  299. Bonner-Weir S, Trent DF, Weir GC. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J Clin Invest. 1983 Jun; 71(6):1544-53. PMID: 6134752; PMCID: PMC370360.
  300. Oie HK, Gazdar AF, Minna JD, Weir GC, Baylin SB. Clonal analysis of insulin and somatostatin secretion and L-dopa decarboxylase expression by a rat islet cell tumor. Endocrinology. 1983 Mar; 112(3):1070-5. PMID: 6129963.
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  301. Halban PA, Bonner-Weir S, Weir GC. Elevated proinsulin biosynthesis in vitro from a rat model of non-insulin-dependent diabetes mellitus. Diabetes. 1983 Mar; 32(3):277-83. PMID: 6337906.
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  302. Fletcher DJ, Trent DF, Weir GC. Catfish somatostatin is unique to piscine tissues. Regul Pept. 1983 Jan; 5(2):181-7. PMID: 6131502.
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  303. Halban PA, Bonner-Weir, S, Weir GC. Increased proinsulin biosynthesis in islets from a rat model of non-insulin dependent diabetes mellitus. Diabetes. 1983; 32:277-283.
  304. Weir GC. Non-insulin-dependent diabetes mellitus: interplay between B-cell inadequacy and insulin resistance. Am J Med. 1982 Oct; 73(4):461-4. PMID: 6751082.
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  305. Fletcher DJ, Grogan WM, Weir GC. Hormone content and acute hormone release of B- cell enriched and A and D cell-enriched populations prepared by flow cytometry. Endocrinology. 1982; 113:1791.
  306. Honey RN, Arimura A, Weir GC. Somatostatin neutralization stimulates glucagon and insulin secretion from the avian pancreas. Endocrinology. 1981 Dec; 109(6):1971-4. PMID: 6118258.
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  307. DuVal JW, Saffouri B, Weir GC, Walsh JH, Arimura A, Makhlouf GM. Stimulation of gastrin and somatostatin secretion from the isolated rat stomach by bombesin. Am J Physiol. 1981 Sep; 241(3):G242-7. PMID: 6116435.
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  308. Bonner-Weir S, Trent DF, Zmachinski CJ, Clore ET, Weir GC. Limited B cell regeneration in a B cell deficient rat model: studies with dexamethasone. Metabolism. 1981 Sep; 30(9):914-8. PMID: 6115303.
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  309. Lankford HV, Weir GC. Cushing's disease and failure of dexamethasone suppression. South Med J. 1981 Aug; 74(8):1002-4. PMID: 7268478.
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  310. Weir GC, Clore ET, Zmachinski CJ, Bonner-Weir S. Islet secretion in a new experimental model for non-insulin-dependent diabetes. Diabetes. 1981 Jul; 30(7):590-5. PMID: 6114005.
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  311. Trent DF, Weir GC. Heterogeneity of somatostatin-like peptides in rat brain, pancreas, and gastrointestinal tract. Endocrinology. 1981 Jun; 108(6):2033-8. PMID: 6112133.
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  312. Samols E, Stagner JI, Weir GC. Autonomic function and control of pancreatic somatostatin. Diabetologia. 1981 Mar; 20(Suppl 1):388-392. PMID: 27942826.
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  313. Samols E, Stagner JI, Weir GC. Autonomic function and control of pancreatic somatostatin. Diabetologia. 1981 Mar; 20 Suppl:388-92. PMID: 6112189.
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  314. Oyama H, Martin J, Sussman K, Weir GC, Permutt A. The biological activity of catfish pancreatic somatostatin. Regul Pept. 1981 Mar; 1(6):387-96. PMID: 6112779.
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  315. DuVal JW, Saffouri B, Weir GC. Walsh JH, Arimura A, Makhlouf GM. Stimulation of gastrin and somatostatin secretion from the isolated rat stomach by bombesin. Am J Physiol. 1981; 241:G242-G247.
  316. Honey RN, Weir GC, Arimura A. Stimulation of avian glucagon and insulin by somatostatin antiserum. Endocrinology. 1981; 109:1971-1974.
  317. Weir GC, Clore ET, Zmachinski CH, Bonner-Weir S. Islet secretion in a new experimental model of non-insulin dependent diabetes mellitus. Diabetes. 1981; 30:590-595.
  318. Bonner-Weir S, Trent DF, Honey RN, Weir GC. Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia. Diabetes. 1981 Jan; 30(1):64-9. PMID: 6112177.
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  319. Honey RN, Fallon MB, Weir GC. Effects of exogenous insulin, glucagon, and somatostatin on islet hormone secretion in the perfused chicken pancreas. Metabolism. 1980 Dec; 29(12):1242-6. PMID: 6109226.
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  320. Bitar KN, Said SI, Weir GC, Saffouri B, Makhlouf GM. Neural release of vasoactive intestinal peptide from the gut. Gastroenterology. 1980 Dec; 79(6):1288-94. PMID: 7439634.
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  321. Chick WL, Appel MC, Weir GC, Like AA, Lauris V, Porter JG, Chute RN. Serially transplantable chemically induced rat islet cell tumor. Endocrinology. 1980 Oct; 107(4):954-60. PMID: 6250800.
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  322. Honey RN, Weir GC. Acetylcholine stimulates insulin, glucagon, and somatostatin release in the perfused chicken pancreas. Endocrinology. 1980 Oct; 107(4):1065-8. PMID: 6105951.
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  323. Saffouri B, Weir GC, Bitar KN, Makhlouf GM. Gastrin and somatostatin secretion by perfused rat stomach: functional linkage of antral peptides. Am J Physiol. 1980 Jun; 238(6):G495-501. PMID: 6104441.
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  324. Gazdar AF, Chick WL, Oie HK, Sims HL, King DL, Weir GC, Lauris V. Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor. Proc Natl Acad Sci U S A. 1980 Jun; 77(6):3519-23. PMID: 6106192; PMCID: PMC349648.
  325. Stagner JI, Samols E, Weir GC. Sustained oscillations of insulin, glucagon, and somatostatin from the isolated canine pancreas during exposure to a constant glucose concentration. J Clin Invest. 1980 Apr; 65(4):939-42. PMID: 6987271; PMCID: PMC434485.
  326. Dudek FE, Weir G, Acosta-Urquidi J, Tobe SS. A secretion from neuroendocrine bag cells evokes egg release in vitro from ovotestis of Aplysia californica. Gen Comp Endocrinol. 1980 Feb; 40(2):241-4. PMID: 6892702.
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  327. Honey RN, Schwarz JA, Mathe CJ, Weir GC. Insulin, glucagon, and somatostatin secretion from isolated perfused rat and chicken pancreas-duodenum. Am J Physiol. 1980 Feb; 238(2):E150-6. PMID: 6444782.
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  328. Weir GC, Bonner-Weir S, Edwards DC. Nerve growth factor and pancreatic APUD cells. Endocr Res Commun. 1980; 7(1):71-5. PMID: 6102510.
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  329. Weir GC, Bonner-Weir S, Edwards DC. Nerve growth factor and the pancreatic APUD cells. Endoc. Res Communications. 1980; 7:71-75.
  330. Weir GC, Schwarz JA, Mathe CJ. Inhibition of glucagon and insulin secretion from the perfused rat pancreas by a B-cell-selective somatostatin analog. Metabolism. 1980 Jan; 29(1):68-70. PMID: 6986012.
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  331. Gazdar AF, Chick WL, Oie HK, Sims HL, King DL, Weir GC. Lauris V.Continuous clonal insulin and somatostatin secreting cell lines established from a trans-plantation rat islet cell tumor. Proc Nat Acad Sci. 1980; 77:3519-3523.
  332. Saffouri B, Weir G, Bitar K, Makhlouf G. Stimulation of gastrin secretion from the perfused rat stomach by somatostatin antiserum. Life Sci. 1979 Nov 12; 25(20):1749-53. PMID: 529985.
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  333. Honey RN, Weir GC. Insulin stimulates somatostatin and inhibits glucagon secretion from the perfused chicken pancreas-duodenum. Life Sci. 1979 May 07; 24(19):1747-50. PMID: 459679.
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  334. Bonner-Weir S, Weir GC. The organization of the endocrine pancreas: a hypothetical unifying view of the phylogenetic differences. Gen Comp Endocrinol. 1979 May; 38(1):28-37. PMID: 381098.
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  335. Samols E, Weir GC. Adrenergic modulation of pancreatic A, B, and D cells alpha-Adrenergic suppression and beta-adrenergic stimulation of somatostatin secretion, alpha-adrenergic stimulation of glucagon secretion in the perfused dog pancreas. J Clin Invest. 1979 Feb; 63(2):230-8. PMID: 34627; PMCID: PMC371944.
  336. Honey RN, Weir GC. Insulin stimulates somatostatin and inhibits glucagon secretion from the perfused chicken pancreas-duodenum. Life Science. 1979; 24:1747-1750.
  337. Samols E, Weir GC. Adrenergic modulation of pancreatic A,B, and D cells. J. Clin Invest. 1979; 63:230-238.
  338. Weir GC, Samols E, Loo S, Patel YC, Gabbay KH. Somatostatin and pancreatic polypeptide secretion: effects of glucagon, insulin, and arginine. Diabetes. 1979 Jan; 28(1):35-40. PMID: 759249.
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  339. Newsome HH Jr., Weir GC, Daniel TM. Norepinephrine-secreting tumor of the organ of Zuckerland: Response to propranolol alone. JAMA. 1979; 242:540-542.
  340. Noe BD, Weir GC, Bauer GE. Biosynthesis of somatostatin in pancreatic islets. Metabolism. 1978 Sep; 27(9 Suppl 1):1201-5. PMID: 355780.
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  341. Weir GC, Samols E, Day JA, Patel YC. Glucose and glucagon stimulate the secretion of somatostatin from the perfused canine pancreas. Metabolism. 1978 Sep; 27(9 Suppl 1):1223-6. PMID: 682984.
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  342. Samols E, Weir GC, Ramseur R, Day JA, Patel YC. Modulation of pancreatic somatostatin by adrenergic and cholinergic agonism and by hyper- and hypoglycemic sulfonamides. Metabolism. 1978 Sep; 27(9 Suppl 1):1219-21. PMID: 682983.
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  343. Noe BD, Fletcher DJ, Bauer GE, Weir GC, Patel Y. Somatostatin biosynthesis occurs in pancreatic islets. Endocrinology. 1978 Jun; 102(6):1675-85. PMID: 369832.
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  344. Noe BD, Bauer GE, Weir GC, Patel YC. Somatostatin biosynthesis in pancreatic islets: Evidence for a precursor. Endocrinology. 1978; 102:1675.
  345. Weir GC, Samols E, Day JA Jr., Patel YC. Glucose and glucagon stimulate the secretion of somatostatin from the perfused canine pancreas. Metab. 1978; 27:1223.
  346. Noe BD, Weir GC. Baer GE. Biosynthesis of somatostatin in pancreatic islets. Metab. 1978; 27:1201.
  347. Witters LA, Ohman JL, Weir GC, Raymond LW, Lowell FC. Insulin antibodies in the pathogenesis of insulin allergy and resistance. Am J Med. 1977 Nov; 63(5):703-9. PMID: 563170.
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  348. Soeters PB, Weir G, Ebeid AM, Fischer JE. Insulin, glucagon, portal systemic shunting, and hepatic failure in the dog. J Surg Res. 1977 Sep; 23(3):183-8. PMID: 886853.
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  349. Ganda OP, Weir GC, Soeldner JS, Legg MA, Chick WL, Patel YC, Ebeid AM, Gabbay KH, Reichlin S. "Somatostatinoma": a somatostatin-containing tumor of the endocrine pancreas. N Engl J Med. 1977 Apr 28; 296(17):963-7. PMID: 321960.
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  350. Weir GC, Horton ES, Aoki TT, Slovik D, Jaspan J, Rubenstein AH. Secretion by glucagonomas of a possible glucagon precursor. J Clin Invest. 1977 Feb; 59(2):325-30. PMID: 833279; PMCID: PMC333363.
  351. Samols E, Weir GC, Ramseur R, Day JA, Patel YC. Modulation of pancreatic somatostatin by adrenergic and cholinergic agonism and by hyper and hypoglycemic sulfonamides. Metab. 1977; 27:1219-1222.
  352. Soeters PB, Weir GC, Ebeid AM, Fischer JE. Changes in insulin and glycagon with onset of hepatic encephalopathy. J. Surg Res. 1977; 23:183-188.
  353. Witters LA, Ohman J, Weir GC, Lowell FC. Insulin allergy and resistance: A clinical study. Am J Med. 1977; 63:703.
  354. Ganda OP, Weir GC, Soeldner SJ, Gabbay K, Patel YC, Reichlin S. Ebeid AM, Legg M. . A Somatostatinoma. N Eng. J. Med. 1977; 296:963-967.
  355. Weir GC, Atkins RF, Martin DB. Glucagon secretion from the perfused rat pancreas following acute and chronic streptozotocin. Metabolism. 1976 Nov; 25(11 Suppl 1):1519-21. PMID: 135913.
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  356. Bucher NL, Weir GC. Insulin, glucagon, liver regeneration, and DNA synthesis. Metabolism. 1976 Nov; 25(11 Suppl 1):1423-5. PMID: 979645.
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  357. Weir GC, Goltsos PC, Steinberg EP, Patel YC. High concentration of somatostatin immunoreactivity in chicken pancreas. Diabetologia. 1976 May; 12(2):129-32. PMID: 773728.
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  358. Weir GC, Knowlton SD, Atkins RF, McKennan KX, Martin DB. Glucagon secretion from the perfused pancreas of streptozotocin-treated rats. Diabetes. 1976 Apr; 25(4):275-82. PMID: 131725.
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  359. Patel YC, Weir GC. Increased somatostatin content of islets from streptozotocin-diabetic rats. Clin Endocrinol (Oxf). 1976 Mar; 5(2):191-4. PMID: 131661.
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  360. Patel YC. Weir GC. Increased somatostatin content of islets from streptozotocin diabetic rats. Clin Endocrinology. 1976; 5:191-194.
  361. Weir GC, Knowlton SD, Martin DB. Nucleotide and nucleoside stimulation of glucagon secretion. Endocrinology. 1975 Oct; 97(4):932-6. PMID: 1104353.
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  362. Weir GC, Lesser PB, Drop LJ, Fischer JE, Warshaw AL. The hypocalcemia of acute pancreatitis. Ann Intern Med. 1975 Aug; 83(2):185-9. PMID: 1147452.
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  363. Weir GC, Knowlton SD, Martin DB. High molecular weight glucagon-like immunoreactivity in plasma. J Clin Endocrinol Metab. 1975 Feb; 40(2):296-302. PMID: 1117980.
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  364. Weir GC, Knowlton SD, Martin DB. Somatostatin inhibition of epinephrine-induced glucagon secretion. Endocrinology. 1974 Dec; 95(6):1744-6. PMID: 4611749.
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  365. Weir GC, Knowlton SD, Martin DB. Glucagon secretion from the perfused rat pancreas. Studies with glucose and catecholamines. J Clin Invest. 1974 Dec; 54(6):1403-12. PMID: 4373494; PMCID: PMC301695.
  366. Rossini AA, Soeldner JS, Hiebert JM, Weir GC, Gleason RE. The effect of glucose anomers upon insulin and glucagon secretion. Diabetologia. 1974 Dec; 10(6):795-9. PMID: 4442670.
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  367. Weir GC, Turner RC, Martin DB. Glucagon radioimmunoassay using antiserum 30K: interference by plasma. Horm Metab Res. 1973 Jul; 5(4):241-4. PMID: 4731271.
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  368. Hamilton CR, Henkin RI, Weir GC, Kliman B. Olfactory status and response in clomiphene in male gonadotropin deficiency. Ann Intern Med. 1973; 78:47.
  369. Weir GC, Martin DB. Fatty acid biosynthesis in the erythrocyte. II. Evidence in immature erythrocytes for the presence of acetyl co-enzyme A carboxylase. J Lab Clin Med. 1973 Jan; 81(1):37-42. PMID: 4734156.
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  370. Hamilton CR, Henkin RI, Weir G, Kliman B. Olfactory status and response to clomiphene in male gonadotrophin deficiency. Ann Intern Med. 1973 Jan; 78(1):47-55. PMID: 4565901.
    View in: PubMed
  371. Weir GC, Turner RD, Martin DB. Glucagon radioimmunoassay using antiserum 30K: Interference by plasma. Horm Met Res. 1973; 5:241.
  372. Weir GC, Martin DB. Fatty acid biosynthesis in the erythrocyte: the effect of red cell age on the integrity of the pathway. Diabetes. 1968; 17:305. PMID: 5655853.
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