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Kenneth Dean Swanson, Ph.D.

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Research
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  1. R56AI085131 (SWANSON, KENNETH DEAN) Aug 15, 2010 - Jul 31, 2012
    NIH/NIAID
    Regulation of innate immune cell signaling by Skap-hom
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shaban L, Nguyen GT, Mecsas-Faxon BD, Swanson KD, Tan S, Mecsas J. Yersinia pseudotuberculosis YopH targets SKAP2-dependent and independent signaling pathways to block neutrophil antimicrobial mechanisms during infection. PLoS Pathog. 2020 05; 16(5):e1008576. PMID: 32392230.
    Citations:    
  2. Nguyen GT, Shaban L, Mack M, Swanson KD, Bunnell SC, Sykes DB, Mecsas J. SKAP2 is required for defense against K. pneumoniae infection and neutrophil respiratory burst. Elife. 2020 Apr 30; 9. PMID: 32352382.
    Citations:    
  3. Bever CS, Swanson KD, Hamelin EI, Filigenzi M, Poppenga RH, Kaae J, Cheng LW, Stanker LH. Rapid, Sensitive, and Accurate Point-of-Care Detection of Lethal Amatoxins in Urine. Toxins (Basel). 2020 02 15; 12(2). PMID: 32075251.
    Citations:    
  4. Canesin G, Hejazi SM, Swanson KD, Wegiel B. Heme-Derived Metabolic Signals Dictate Immune Responses. Front Immunol. 2020; 11:66. PMID: 32082323.
    Citations:    
  5. Krajewski LC, Swanson KD, Bragg WA, Shaner RL, Seymour C, Carter MD, Hamelin EI, Johnson RC. Application of the fentanyl analog screening kit toward the identification of emerging synthetic opioids in human plasma and urine by LC-QTOF. Toxicol Lett. 2020 Mar 01; 320:87-94. PMID: 31812604.
    Citations:    
  6. Riley MM, San P, Lok E, Swanson KD, Wong ET. The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma. J Vis Exp. 2019 04 16; (146). PMID: 31058901.
    Citations:    
  7. Wong ET, Swanson KD. Dexamethasone-Friend or Foe for Patients With Glioblastoma? JAMA Neurol. 2019 03 01; 76(3):247-248. PMID: 30667471.
    Citations:    Fields:    
  8. Timmons JJ, Zhang K, Fong J, Lok E, Swanson KD, Gautam S, Wong ET. Literature Review of Spinal Cord Glioblastoma. Am J Clin Oncol. 2018 12; 41(12):1281-1287. PMID: 29528867.
    Citations: 1     Fields:    
  9. Swanson KD, Theodorou E, Kokkotou E. Reproducing the human mucosal environment ex vivo: inflammatory bowel disease as a paradigm. Curr Opin Gastroenterol. 2018 11; 34(6):384-391. PMID: 30188406.
    Citations:    Fields:    
  10. Wong ET, Lok E, Swanson KD. Alternating Electric Fields Therapy for Malignant Gliomas: From Bench Observation to Clinical Reality. Prog Neurol Surg. 2018; 32:180-195. PMID: 29990984.
    Citations:    Fields:    Translation:Humans
  11. Wong ET, Swanson KD. Everolimus shortens survival of newly diagnosed glioblastoma patients. J Neurooncol. 2018 Oct; 140(1):179-180. PMID: 29956084.
    Citations:    Fields:    
  12. Swanson KD, Zheng B. Supplementing Cancer? Mol Cell. 2018 03 15; 69(6):917-918. PMID: 29547718.
    Citations:    Fields:    Translation:HumansCells
  13. Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG. ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPa. J Biol Chem. 2017 11 17; 292(46):18924-18936. PMID: 28900037.
    Citations:    Fields:    Translation:HumansCells
  14. Swanson KD, Worth AL, Glish GL. Use of an Open Port Sampling Interface Coupled to Electrospray Ionization for the On-Line Analysis of Organic Aerosol Particles. J Am Soc Mass Spectrom. 2018 02; 29(2):297-303. PMID: 28895085.
    Citations:    Fields:    
  15. Kim SH, Li M, Trousil S, Zhang Y, Pasca di Magliano M, Swanson KD, Zheng B. Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma. J Invest Dermatol. 2017 08; 137(8):1740-1748. PMID: 28433543.
    Citations: 11     Fields:    Translation:AnimalsCells
  16. Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC. Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity. Cancer Discov. 2017 07; 7(7):750-765. PMID: 28274958.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  17. Swanson KD, Spencer SE, Glish GL. Metal Cationization Extractive Electrospray Ionization Mass Spectrometry of Compounds Containing Multiple Oxygens. J Am Soc Mass Spectrom. 2017 06; 28(6):1030-1035. PMID: 27896697.
    Citations: 2     Fields:    
  18. Gera N, Swanson KD, Jin T. ß-Arrestin 1-dependent regulation of Rap2 is required for fMLP-stimulated chemotaxis in neutrophil-like HL-60 cells. J Leukoc Biol. 2017 01; 101(1):239-251. PMID: 27493245.
    Citations: 1     Fields:    Translation:HumansCells
  19. Swanson KD, Lok E, Wong ET. An Overview of Alternating Electric Fields Therapy (NovoTTF Therapy) for the Treatment of Malignant Glioma. Curr Neurol Neurosci Rep. 2016 Jan; 16(1):8. PMID: 26739692.
    Citations: 6     Fields:    Translation:HumansAnimals
  20. Wong ET, Lok E, Gautam S, Swanson KD. Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma. Br J Cancer. 2015 Dec 01; 113(11):1642. PMID: 26625224.
    Citations: 3     Fields:    
  21. Lok E, Swanson KD, Wong ET. Tumor treating fields therapy device for glioblastoma: physics and clinical practice considerations. Expert Rev Med Devices. 2015; 12(6):717-26. PMID: 26513694.
    Citations: 2     Fields:    Translation:Humans
  22. Wong ET, Swanson KD. Response to: Comment on 'Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma'. Br J Cancer. 2015 Dec 01; 113(11):1633-4. PMID: 26348442.
    Citations:    Fields:    Translation:Humans
  23. Wong ET, Lok E, Swanson KD. An Evidence-Based Review of Alternating Electric Fields Therapy for Malignant Gliomas. Curr Treat Options Oncol. 2015 Aug; 16(8):40. PMID: 26143265.
    Citations: 7     Fields:    Translation:Humans
  24. Wong ET, Lok E, Gautam S, Swanson KD. Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma. Br J Cancer. 2015 Jul 14; 113(2):232-41. PMID: 26125449.
    Citations: 13     Fields:    Translation:HumansCells
  25. Gera N, Yang A, Holtzman TS, Lee SX, Wong ET, Swanson KD. Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit. PLoS One. 2015; 10(5):e0125269. PMID: 26010837.
    Citations: 15     Fields:    Translation:HumansCells
  26. Wong ET, Lok E, Swanson KD. Clinical benefit in recurrent glioblastoma from adjuvant NovoTTF-100A and TCCC after temozolomide and bevacizumab failure: a preliminary observation. Cancer Med. 2015 Mar; 4(3):383-91. PMID: 25620708.
    Citations: 4     Fields:    Translation:Humans
  27. Lok E, Chung AS, Swanson KD, Wong ET. Melanoma brain metastasis globally reconfigures chemokine and cytokine profiles in patient cerebrospinal fluid. Melanoma Res. 2014 Apr; 24(2):120-30. PMID: 24463459.
    Citations: 7     Fields:    Translation:Humans
  28. Wong ET, Lok E, Swanson KD, Gautam S, Engelhard HH, Lieberman F, Taillibert S, Ram Z, Villano JL. Response assessment of NovoTTF-100A versus best physician's choice chemotherapy in recurrent glioblastoma. Cancer Med. 2014 Jun; 3(3):592-602. PMID: 24574359.
    Citations: 9     Fields:    Translation:Humans
  29. Alenghat FJ, Baca QJ, Rubin NT, Pao LI, Matozaki T, Lowell CA, Golan DE, Neel BG, Swanson KD. Macrophages require Skap2 and Sirpa for integrin-stimulated cytoskeletal rearrangement. J Cell Sci. 2012 Nov 15; 125(Pt 22):5535-45. PMID: 22976304.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  30. Locasale JW, Melman T, Song S, Yang X, Swanson KD, Cantley LC, Wong ET, Asara JM. Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. Mol Cell Proteomics. 2012 Jun; 11(6):M111.014688. PMID: 22240505.
    Citations: 30     Fields:    Translation:Humans
  31. Fang Z, Zhang T, Dizeyi N, Chen S, Wang H, Swanson KD, Cai C, Balk SP, Yuan X. Androgen Receptor Enhances p27 Degradation in Prostate Cancer Cells through Rapid and Selective TORC2 Activation. J Biol Chem. 2012 Jan 13; 287(3):2090-8. PMID: 22139837.
    Citations: 22     Fields:    Translation:AnimalsCells
  32. Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science. 2010 Sep 17; 329(5998):1492-9. PMID: 20847263.
    Citations: 225     Fields:    Translation:HumansAnimalsCells
  33. Li B, Castano AP, Hudson TE, Nowlin BT, Lin SL, Bonventre JV, Swanson KD, Duffield JS. The melanoma-associated transmembrane glycoprotein Gpnmb controls trafficking of cellular debris for degradation and is essential for tissue repair. FASEB J. 2010 Dec; 24(12):4767-81. PMID: 20709912.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  34. Stewart RA, Sanda T, Widlund HR, Zhu S, Swanson KD, Hurley AD, Bentires-Alj M, Fisher DE, Kontaridis MI, Look AT, Neel BG. Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis. Dev Cell. 2010 May 18; 18(5):750-62. PMID: 20493809.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  35. Swanson KD, Tang Y, Ceccarelli DF, Poy F, Sliwa JP, Neel BG, Eck MJ. The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch. Mol Cell. 2008 Nov 21; 32(4):564-75. PMID: 19026786.
    Citations: 16     Fields:    Translation:AnimalsCells
  36. Wong ET, Yu M, Song S, Jeyapalan S, Groves M, Swanson KD, Gautam S. Vascular endothelial growth factor and matrix metalloprotease in lymphomatous meningitis. J Clin Oncol. 2008 May 20; 26(15_suppl):2031. PMID: 27948067.
    Citations:    
  37. Swanson KD, Winter JM, Reis M, Bentires-Alj M, Greulich H, Grewal R, Hruban RH, Yeo CJ, Yassin Y, Iartchouk O, Montgomery K, Whitman SP, Caligiuri MA, Loh ML, Gilliland DG, Look AT, Kucherlapati R, Kern SE, Meyerson M, Neel BG. SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients. Genes Chromosomes Cancer. 2008 Mar; 47(3):253-9. PMID: 18064648.
    Citations: 13     Fields:    Translation:Humans
  38. Kratz CP, Niemeyer CM, Thomas C, Bauhuber S, Matejas V, Bergsträsser E, Flotho C, Flores NJ, Haas O, Hasle H, van den Heuvel-Eibrink MM, Kucherlapati RS, Lang P, Roberts AE, Starý J, Strahm B, Swanson KD, Trebo M, Zecca M, Neel B, Locatelli F, Loh ML, Zenker M. Mutation analysis of Son of Sevenless in juvenile myelomonocytic leukemia. Leukemia. 2007 May; 21(5):1108-9. PMID: 17315019.
    Citations: 8     Fields:    Translation:Humans
  39. Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS. Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat Genet. 2007 Jan; 39(1):70-4. PMID: 17143285.
    Citations: 140     Fields:    Translation:Humans
  40. Kasirer-Friede A, Moran B, Nagrampa-Orje J, Swanson K, Ruggeri ZM, Schraven B, Neel BG, Koretzky G, Shattil SJ. ADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists. Blood. 2007 Feb 01; 109(3):1018-25. PMID: 17003372.
    Citations: 16     Fields:    Translation:AnimalsCells
  41. Kontaridis MI, Swanson KD, David FS, Barford D, Neel BG. PTPN11 (Shp2) mutations in LEOPARD syndrome have dominant negative, not activating, effects. J Biol Chem. 2006 Mar 10; 281(10):6785-92. PMID: 16377799.
    Citations: 101     Fields:    Translation:HumansCells
  42. Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, Gerber A. Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM. Mol Cell Biol. 2005 Sep; 25(18):8052-63. PMID: 16135797.
    Citations: 27     Fields:    Translation:AnimalsCells
  43. Lee SR, Ramos SM, Ko A, Masiello D, Swanson KD, Lu ML, Balk SP. AR and ER interaction with a p21-activated kinase (PAK6). Mol Endocrinol. 2002 Jan; 16(1):85-99. PMID: 11773441.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  44. Timms JF, Swanson KD, Marie-Cardine A, Raab M, Rudd CE, Schraven B, Neel BG. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages. Curr Biol. 1999 Aug 26; 9(16):927-30. PMID: 10469599.
    Citations: 21     Fields:    Translation:AnimalsCells
  45. Swanson KD, Reigh C, Landreth GE. ATP-stimulated activation of the mitogen-activated protein kinases through ionotrophic P2X2 purinoreceptors in PC12 cells. Difference in purinoreceptor sensitivity in two PC12 cell lines. J Biol Chem. 1998 Aug 07; 273(32):19965-71. PMID: 9685331.
    Citations: 11     Fields:    Translation:AnimalsCells
  46. Taylor LK, Swanson KD, Kerigan J, Mobley W, Landreth GE. Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells. J Biol Chem. 1994 Jan 07; 269(1):308-18. PMID: 8276812.
    Citations: 8     Fields:    Translation:AnimalsCells
  47. Swanson KD, Dhar MS, Joshi JG. The human and bovine 14-3-3 eta protein mRNAs are highly conserved in both their translated and untranslated regions. Biochim Biophys Acta. 1993 Oct 19; 1216(1):145-8. PMID: 8218406.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  48. Swanson KD, Ganguly R. Characterization of a Drosophila melanogaster gene similar to the mammalian genes encoding the tyrosine/tryptophan hydroxylase activator and protein kinase C inhibitor proteins. Gene. 1992 Apr 15; 113(2):183-90. PMID: 1349290.
    Citations: 11     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.