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Louis Chu, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kundi H, Popma JJ, Khabbaz KR, Chu LM, Strom JB, Valsdottir LR, Shen C, Yeh RW. Association of Hospital Surgical Aortic Valve Replacement Quality With 30-Day and 1-Year Mortality After Transcatheter Aortic Valve Replacement. JAMA Cardiol. 2019 Jan 01; 4(1):16-22. PMID: 30516798.
    Citations:    Fields:    
  2. Mahmood E, Jeganathan J, Feng R, Saraf M, Khabbaz K, Mahmood F, Venkatachalam S, Liu D, Chu L, Parikh SM, Matyal R. Decreased PGC-1a Post-Cardiopulmonary Bypass Leads to Impaired Oxidative Stress in Diabetic Patients. Ann Thorac Surg. 2019 Feb; 107(2):467-476. PMID: 30291832.
    Citations:    Fields:    
  3. Kundi H, Popma JJ, Cohen DJ, Liu DC, Laham RJ, Pinto DS, Chu LM, Strom JB, Shen C, Yeh RW. Prevalence and Outcomes of Isolated Tricuspid Valve Surgery Among Medicare Beneficiaries. Am J Cardiol. 2019 Jan 01; 123(1):132-138. PMID: 30442362.
    Citations:    Fields:    
  4. Carroll BJ, Pemberton H, Bauer KA, Chu LM, Weinstein JL, Levarge BL, Pinto DS. Initiation of a Multidisciplinary, Rapid Response Team to Massive and Submassive Pulmonary Embolism. Am J Cardiol. 2017 Oct 15; 120(8):1393-1398. PMID: 28807405.
    Citations: 1     Fields:    Translation:Humans
  5. Scrimgeour LA, Potz BA, Elmadhun NY, Chu LM, Sellke FW. Alcohol attenuates myocardial ischemic injury. Surgery. 2017 09; 162(3):680-687. PMID: 28602493.
    Citations:    Fields:    Translation:Animals
  6. Nemec U, Heidinger B, Sokas C, Chu L, Eisenberg RL. Diagnosing Sarcopenia on Thoracic Computed Tomography: Quantitative Assessment of Skeletal Muscle Mass in Patients Undergoing Transcatheter Aortic Valve Replacement. Acad Radiol. 2017 09; 24(9):1154-1161. PMID: 28365235.
    Citations: 2     Fields:    Translation:Humans
  7. Sabe AA, Elmadhun NY, Sadek AA, Dalal RS, Chu LM, Bianchi C, Sellke FW. Atorvastatin regulates apoptosis in chronically ischemic myocardium. J Card Surg. 2015 Feb; 30(2):218-23. PMID: 25511504.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Sabe AA, Dalal RS, Chu LM, Elmadhun NY, Ramlawi B, Bianchi C, Sellke FW. Preoperative gene expression may be associated with neurocognitive decline after cardiopulmonary bypass. J Thorac Cardiovasc Surg. 2015 Feb; 149(2):613-22; discussion 622-3. PMID: 25483902.
    Citations: 2     Fields:    Translation:Humans
  9. Sabe AA, Elmadhun NY, Sadek AA, Chu LM, Bianchi C, Sellke FW. Differential effects of atorvastatin on autophagy in ischemic and nonischemic myocardium in Ossabaw swine with metabolic syndrome. J Thorac Cardiovasc Surg. 2014 Dec; 148(6):3172-8. PMID: 25240527.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Elmadhun NY, Sabe AA, Lassaletta AD, Chu LM, Kondra K, Sturek M, Sellke FW. Metabolic syndrome impairs notch signaling and promotes apoptosis in chronically ischemic myocardium. J Thorac Cardiovasc Surg. 2014 Sep; 148(3):1048-55; discussion 1055. PMID: 25037620.
    Citations: 6     Fields:    Translation:AnimalsCells
  11. Elmadhun NY, Sabe AA, Lassaletta AD, Chu LM, Sellke FW. Metformin mitigates apoptosis in ischemic myocardium. J Surg Res. 2014 Nov; 192(1):50-8. PMID: 24969550.
    Citations: 8     Fields:    Translation:AnimalsCells
  12. Lassaletta AD, Elmadhun NY, Burgess TA, Bianchi C, Sabe AA, Robich MP, Chu LM, Sellke FW. Microvascular notch signaling is upregulated in response to vascular endothelial growth factor and chronic myocardial ischemia. Circ J. 2014; 78(3):743-51. PMID: 24366099.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Feng J, Liu Y, Dobrilovic N, Chu LM, Bianchi C, Singh AK, Sellke FW. Altered apoptosis-related signaling after cardioplegic arrest in patients with uncontrolled type 2 diabetes mellitus. Circulation. 2013 Sep 10; 128(11 Suppl 1):S144-51. PMID: 24030399.
    Citations: 7     Fields:    Translation:Humans
  14. Elmadhun NY, Sabe AA, Robich MP, Chu LM, Lassaletta AD, Sellke FW. The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease. Ann N Y Acad Sci. 2013 Jul; 1290:130-5. PMID: 23855475.
    Citations: 8     Fields:    Translation:HumansAnimals
  15. Elmadhun NY, Lassaletta AD, Chu LM, Sellke FW. Metformin alters the insulin signaling pathway in ischemic cardiac tissue in a swine model of metabolic syndrome. J Thorac Cardiovasc Surg. 2013 Jan; 145(1):258-65; discussion 265-6. PMID: 23083540.
    Citations: 7     Fields:    Translation:AnimalsCells
  16. Lassaletta AD, Chu LM, Elmadhun NY, Robich MP, Hoffman ZG, Kim DJ, Sellke FW. Mechanism for reduced pericardial adhesion formation in hypercholesterolemic swine supplemented with alcohol. Eur J Cardiothorac Surg. 2013 May; 43(5):1058-64. PMID: 22991457.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Elmadhun NY, Lassaletta AD, Chu LM, Liu Y, Feng J, Sellke FW. Atorvastatin increases oxidative stress and modulates angiogenesis in Ossabaw swine with the metabolic syndrome. J Thorac Cardiovasc Surg. 2012 Dec; 144(6):1486-93. PMID: 22995723.
    Citations: 4     Fields:    Translation:AnimalsCells
  18. Matyal R, Chu L, Mahmood F, Robich MP, Wang A, Hess PE, Shahul S, Pinto DS, Khabbaz K, Sellke FW. Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia. J Mol Cell Cardiol. 2012 Dec; 53(6):891-8. PMID: 22982235.
    Citations: 5     Fields:    Translation:Animals
  19. Feng J, Liu Y, Chu LM, Singh AK, Dobrilovic N, Fingleton JG, Clements RT, Bianchi C, Sellke FW. Changes in microvascular reactivity after cardiopulmonary bypass in patients with poorly controlled versus controlled diabetes. Circulation. 2012 Sep 11; 126(11 Suppl 1):S73-80. PMID: 22965996.
    Citations: 13     Fields:    Translation:HumansCells
  20. Chu LM, Lassaletta AD, Robich MP, Liu Y, Burgess T, Laham RJ, Sweeney JD, Shen TL, Sellke FW. Effects of red wine and vodka on collateral-dependent perfusion and cardiovascular function in hypercholesterolemic swine. Circulation. 2012 Sep 11; 126(11 Suppl 1):S65-72. PMID: 22965995.
    Citations: 12     Fields:    Translation:Animals
  21. Elmadhun NY, Lassaletta AD, Chu LM, Bianchi C, Sellke FW. Vodka and wine consumption in a swine model of metabolic syndrome alters insulin signaling pathways in the liver and skeletal muscle. Surgery. 2012 Sep; 152(3):414-22. PMID: 22938901.
    Citations: 7     Fields:    Translation:AnimalsCells
  22. Robich MP, Chu LM, Burgess TA, Feng J, Han Y, Nezafat R, Leber MP, Laham RJ, Manning WJ, Sellke FW. Resveratrol preserves myocardial function and perfusion in remote nonischemic myocardium in a swine model of metabolic syndrome. J Am Coll Surg. 2012 Nov; 215(5):681-9. PMID: 22867714.
    Citations: 11     Fields:    Translation:Animals
  23. Feng J, Chu LM, Dobrilovic N, Liu Y, Singh AK, Sellke FW. Decreased coronary microvascular reactivity after cardioplegic arrest in patients with uncontrolled diabetes mellitus. Surgery. 2012 Aug; 152(2):262-9. PMID: 22828147.
    Citations: 8     Fields:    Translation:Humans
  24. Lassaletta AD, Chu LM, Elmadhun NY, Burgess TA, Feng J, Robich MP, Sellke FW. Cardioprotective effects of red wine and vodka in a model of endothelial dysfunction. J Surg Res. 2012 Dec; 178(2):586-92. PMID: 22748601.
    Citations: 5     Fields:    Translation:Animals
  25. Sellke FW, Lassaletta AD, Robich MP, Chu LM, Ruel M. Regenerative therapies for improving myocardial perfusion in patients with cardiovascular disease: failure to meet expectations but optimism for the future. Curr Vasc Pharmacol. 2012 May; 10(3):300-9. PMID: 22239632.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Lassaletta AD, Chu LM, Sellke FW. Effects of alcohol on pericardial adhesion formation in hypercholesterolemic swine. J Thorac Cardiovasc Surg. 2012 Apr; 143(4):953-9. PMID: 22244558.
    Citations: 2     Fields:    Translation:Animals
  27. Lassaletta AD, Chu LM, Robich MP, Elmadhun NY, Feng J, Burgess TA, Laham RJ, Sturek M, Sellke FW. Overfed Ossabaw swine with early stage metabolic syndrome have normal coronary collateral development in response to chronic ischemia. Basic Res Cardiol. 2012 Mar; 107(2):243. PMID: 22231675.
    Citations: 24     Fields:    Translation:Animals
  28. Chu LM, Lassaletta AD, Robich MP, Sellke FW. Resveratrol in the prevention and treatment of coronary artery disease. Curr Atheroscler Rep. 2011 Dec; 13(6):439-46. PMID: 21870059.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  29. Robich MP, Chu LM, Oyamada S, Sodha NR, Sellke FW. Myocardial therapeutic angiogenesis: a review of the state of development and future obstacles. Expert Rev Cardiovasc Ther. 2011 Nov; 9(11):1469-79. PMID: 22059795.
    Citations: 5     Fields:    Translation:HumansAnimals
  30. Chu LM, Robich MP, Bianchi C, Feng J, Liu Y, Xu SH, Burgess T, Sellke FW. Effects of cyclooxygenase inhibition on cardiovascular function in a hypercholesterolemic swine model of chronic ischemia. Am J Physiol Heart Circ Physiol. 2012 Jan; 302(2):H479-88. PMID: 22037194.
    Citations: 4     Fields:    Translation:Animals
  31. Chu LM, Robich MP, Lassaletta AD, Feng J, Xu SH, Heinl R, Liu Y, Sellke E, Sellke FW. High-fat diet alters prostanoid balance and perfusion in ischemic myocardium of naproxen-treated swine. Surgery. 2011 Sep; 150(3):490-6. PMID: 21878235.
    Citations: 1     Fields:    Translation:Animals
  32. Feng J, Liu Y, Chu LM, Clements RT, Khabbaz KR, Robich MP, Bianchi C, Sellke FW. Thromboxane-induced contractile response of human coronary arterioles is diminished after cardioplegic arrest. Ann Thorac Surg. 2011 Sep; 92(3):829-36. PMID: 21871266.
    Citations: 9     Fields:    Translation:Humans
  33. Feng J, Liu Y, Singh AK, Dobrilovic N, Feng WC, Chu LM, Robich MP, Khabbaz KR, Sellke FW. Impaired contractile response of human peripheral arterioles to thromboxane A-2 after cardiopulmonary bypass. Surgery. 2011 Aug; 150(2):263-71. PMID: 21801963.
    Citations: 2     Fields:    Translation:Humans
  34. Oyamada S, Bianchi C, Takai S, Chu LM, Sellke FW. Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion. J Pharmacol Exp Ther. 2011 Oct; 339(1):143-51. PMID: 21795433.
    Citations: 23     Fields:    Translation:AnimalsCells
  35. Chu LM, Robich MP, Lassaletta AD, Feng J, Laham RJ, Burgess T, Clements RT, Sellke FW. Resveratrol supplementation abrogates pro-arteriogenic effects of intramyocardial vascular endothelial growth factor in a hypercholesterolemic swine model of chronic ischemia. Surgery. 2011 Sep; 150(3):390-9. PMID: 21783219.
    Citations: 3     Fields:    Translation:AnimalsCells
  36. Chu LM, Robich MP, Lassaletta A, Burgess T, Liu Y, Sellke N, Sellke FW. Hypercholesterolemia and chronic ischemia alter myocardial responses to selective cyclooxygenase-2 inhibition. J Thorac Cardiovasc Surg. 2011 Sep; 142(3):675-81. PMID: 21762932.
    Citations:    Fields:    Translation:HumansAnimals
  37. Lassaletta AD, Chu LM, Sellke FW. Therapeutic neovascularization for coronary disease: current state and future prospects. Basic Res Cardiol. 2011 Nov; 106(6):897-909. PMID: 21713563.
    Citations: 19     Fields:    Translation:HumansAnimals
  38. Robich MP, Osipov RM, Chu LM, Han Y, Feng J, Nezafat R, Clements RT, Manning WJ, Sellke FW. Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia. Eur J Pharmacol. 2011 Aug 16; 664(1-3):45-53. PMID: 21575630.
    Citations: 23     Fields:    Translation:AnimalsCells
  39. Burgess TA, Robich MP, Chu LM, Bianchi C, Sellke FW. Improving glucose metabolism with resveratrol in a swine model of metabolic syndrome through alteration of signaling pathways in the liver and skeletal muscle. Arch Surg. 2011 May; 146(5):556-64. PMID: 21739664.
    Citations: 17     Fields:    Translation:AnimalsCells
  40. Robich MP, Chu LM, Burgess TA, Feng J, Bianchi C, Sellke FW. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on myocardial function and perfusion. J Cardiovasc Pharmacol. 2011 Jan; 57(1):122-30. PMID: 21233641.
    Citations: 6     Fields:    Translation:Animals
  41. Robich MP, Chu LM, Feng J, Burgess TA, Laham RJ, Bianchi C, Sellke FW. Effects of selective cyclooxygenase-2 and nonselective cyclooxygenase inhibition on ischemic myocardium. J Thorac Cardiovasc Surg. 2010 Nov; 140(5):1143-52. PMID: 20804993.
    Citations: 5     Fields:    Translation:Animals
  42. Chu LM, Osipov RM, Robich MP, Feng J, Sheller MR, Sellke FW. Effect of thrombin fragment (TP508) on myocardial ischemia reperfusion injury in a model of type 1 diabetes mellitus. Circulation. 2010 Sep 14; 122(11 Suppl):S162-9. PMID: 20837908.
    Citations: 4     Fields:    Translation:Animals
  43. Feng J, Chu LM, Robich MP, Clements RT, Khabbaz KR, Hagberg R, Liu Y, Osipov RM, Sellke FW. Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation. Circulation. 2010 Sep 14; 122(11 Suppl):S150-5. PMID: 20837906.
    Citations: 10     Fields:    Translation:HumansCells
  44. Robich MP, Matyal R, Chu LM, Feng J, Xu SH, Laham RJ, Hess PE, Bianchi C, Sellke FW. Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia. J Mol Cell Cardiol. 2010 Dec; 49(6):1022-30. PMID: 20826160.
    Citations: 13     Fields:    Translation:Animals
  45. Robich MP, Osipov RM, Chu LM, Feng J, Burgess TA, Oyamada S, Clements RT, Laham RJ, Sellke FW. Temporal and spatial changes in collateral formation and function during chronic myocardial ischemia. J Am Coll Surg. 2010 Oct; 211(4):470-80. PMID: 20729101.
    Citations: 1     Fields:    Translation:Animals
  46. Chu LM, Osipov RM, Robich MP, Feng J, Oyamada S, Bianchi C, Sellke FW. Is hyperglycemia bad for the heart during acute ischemia? J Thorac Cardiovasc Surg. 2010 Dec; 140(6):1345-52. PMID: 20542299.
    Citations: 11     Fields:    Translation:AnimalsCells
  47. Robich MP, Chu LM, Chaudray M, Nezafat R, Han Y, Clements RT, Laham RJ, Manning WJ, Coady MA, Sellke FW. Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome. Surgery. 2010 Aug; 148(2):453-62. PMID: 20570307.
    Citations: 16     Fields:    Translation:Animals
  48. Sellke FW, Chu LM, Cohn WE. Current state of surgical myocardial revascularization. Circ J. 2010 Jun; 74(6):1031-7. PMID: 20467145.
    Citations: 5     Fields:    Translation:Humans
  49. Oyamada S, Bianchi C, Takai S, Robich MP, Clements RT, Chu L, Sellke FW. Impact of acute myocardial ischemia reperfusion on the tissue and blood-borne renin-angiotensin system. Basic Res Cardiol. 2010 Jul; 105(4):513-22. PMID: 20340028.
    Citations: 6     Fields:    Translation:Animals
  50. Chu LM, Sellke FW. Invited commentary. Ann Thorac Surg. 2010 Feb; 89(2):520-1. PMID: 20103335.
    Citations:    Fields:    Translation:HumansCells
  51. Sodha NR, Chu LM, Boodhwani M, Sellke FW. Pharmacotherapy for end-stage coronary artery disease. Expert Opin Pharmacother. 2010 Feb; 11(2):207-13. PMID: 20088742.
    Citations: 5     Fields:    Translation:HumansAnimals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.