Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Raymond H Mak, M.D.

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Mentoring
current student opportunities
Available: 04/05/22, Expires: 06/01/23

I am currently focused on developing clinically-applicable deep-learning-based biomarkers to predict response to radiation therapy in patients with lung cancer. We have developed a clinical dataset with accompanying genomic, radiomic (scans with quantitative imaging features) and radiation therapy plans in over 2000 patients with NSCLC. We utilize this dataset to develop automated tools to improve the efficiency and safety of radiation therapy.

Available: 07/01/19, Expires: 07/01/24

Work with a group of data scientists, radiation oncologists and physicists to develop AI applications to automate radiation therapy planning. Student roles could include more technical work (coding) or more clinically oriented projects such as gathering and curating clinical data and imaging, designing and helping to run clinical trials to test AI applications. Time commitments are flexible.

completed student projects
Genetic and Clinical Predictors of Radiation Esophagitis in Lung Cancer Treatment
Summer, 06/17/13 - 08/16/13
Evaluation of CT Imaging Features of Non-Small Cell Lung Cancer During Chemoradiation
Full Time/Year Long, 08/01/14 - 08/15/15
Use of Frailty to Predict Survival in Elderly Patients with Early Stage Non-Small-Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy
Full Time/Year Long, 09/01/15 - 09/30/16

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Qi XS, Albuquerque K, Bailey S, Dawes S, Kashani R, Li H, Mak RH, Mundt AJ, Sio TT. Quality and Safety Considerations in Image Guided Radiation Therapy: An ASTRO Safety White Paper Update. Pract Radiat Oncol. 2023 Mar-Apr; 13(2):97-111. PMID: 36585312.
    Citations:    Fields:    
  2. McKenzie E, Zhang S, Zakariaee R, Guthier CV, Hakimian B, Mirhadi A, Kamrava M, Padda SK, Lewis JH, Nikolova A, Mak RH, Atkins KM. Left Anterior Descending Coronary Artery Radiation Dose Association With All-Cause Mortality in NRG Oncology Trial RTOG 0617. Int J Radiat Oncol Biol Phys. 2022 Nov 24. PMID: 36436615.
    Citations: 1     Fields:    
  3. Chuong MD, Clark MA, Henke LE, Kishan AU, Portelance L, Parikh PJ, Bassetti MF, Nagar H, Rosenberg SA, Mehta MP, Refaat T, Rineer JM, Smith A, Seung S, Zaki BI, Fuss M, Mak RH. Patterns of utilization and clinical adoption of 0.35 Tesla MR-guided radiation therapy in the United States - Understanding the transition to adaptive, ultra-hypofractionated treatments. Clin Transl Radiat Oncol. 2023 Jan; 38:161-168. PMID: 36466748; PMCID: PMC9712826.
    Citations: 1     
  4. Gao SJ, Jin L, Meadows HW, Shafman TD, Gross CP, Yu JB, Aerts HJWL, Miccio JA, Stahl JM, Mak RH, Decker RH, Kann BH. Prediction of Distant Metastases After Stereotactic Body Radiation Therapy for Early Stage NSCLC: Development and External Validation of a Multi-Institutional Model. J Thorac Oncol. 2023 Mar; 18(3):339-349. PMID: 36396062.
    Citations:    Fields:    
  5. Whitaker J, Bredfeldt J, Williams SE, Qian P, Chang D, Mak RH, Cochet H, Sauer W, Zei PC, Tedrow U. Ventricular Conduction Velocity Following Multimodal Ablation Including Stereotactic Body Radiation Therapy for Refractory Ventricular Tachycardia. JACC Clin Electrophysiol. 2023 01; 9(1):119-121. PMID: 36697191.
    Citations:    Fields:    Translation:Humans
  6. Hsu SH, Han Z, Leeman JE, Hu YH, Mak RH, Sudhyadhom A. Synthetic CT generation for MRI-guided adaptive radiotherapy in prostate cancer. Front Oncol. 2022; 12:969463. PMID: 36212472; PMCID: PMC9539763.
    Citations:    
  7. Hosny A, Bitterman DS, Guthier CV, Qian JM, Roberts H, Perni S, Saraf A, Peng LC, Pashtan I, Ye Z, Kann BH, Kozono DE, Christiani D, Catalano PJ, Aerts HJWL, Mak RH. Clinical validation of deep learning algorithms for radiotherapy targeting of non-small-cell lung cancer: an observational study. Lancet Digit Health. 2022 09; 4(9):e657-e666. PMID: 36028289; PMCID: PMC9435511.
    Citations:    Fields:    Translation:Humans
  8. McGurk R, Woch Naheedy K, Kosak T, Hobbs A, Mullins BT, Paradis KC, Kearney M, Roback D, Durney J, Adapa K, Chera BS, Marks LB, Moran JM, Mak RH, Mazur LM. Multi-Institutional Stereotactic Body Radiation Therapy Incident Learning: Evaluation of Safety Barriers Using a Human Factors Analysis and Classification System. J Patient Saf. 2023 01 01; 19(1):e18-e24. PMID: 35948321; PMCID: PMC9771927.
    Citations:    Fields:    Translation:Humans
  9. Chua GT, Greenhawt M, Shaker M, Soller L, Abrams EM, Cameron SB, Cook VE, Erdle SC, Fleischer DM, Mak R, Vander Leek TK, Chan ES. The Case for Prompt Salvage Infant Peanut Oral Immunotherapy Following Failed Primary Prevention. J Allergy Clin Immunol Pract. 2022 10; 10(10):2561-2569. PMID: 35752433.
    Citations:    Fields:    
  10. Wei C, Boeck M, Qian PC, Vivenzio T, Elizee Z, Bredfeldt JS, Kaplan RS, Tedrow U, Mak R, Zei PC. Cost of cardiac stereotactic body radioablation therapy versus catheter ablation for treatment of ventricular tachycardia. Pacing Clin Electrophysiol. 2022 09; 45(9):1124-1131. PMID: 35621224.
    Citations:    Fields:    
  11. Mahmood U, Huynh MA, Killoran JH, Qian JM, Bent EH, Aizer AA, Mak RH, Mamon HJ, Balboni TA, Gunasti L, Ott PA, Awad MM, Schoenfeld JD. Retrospective Review of Outcomes After Radiation Therapy for Oligoprogressive Disease on Immune Checkpoint Blockade. Int J Radiat Oncol Biol Phys. 2022 11 15; 114(4):666-675. PMID: 35643252.
    Citations: 1     Fields:    
  12. Yang DD, Brennan VS, Huynh E, Williams CL, Han Z, Ampofo N, Vastola ME, Sangal P, Singer L, Mak RH, Leeman JE, Cagney DN, Huynh MA. Stereotactic Magnetic Resonance-Guided Adaptive Radiation Therapy (SMART) for Abdominopelvic Oligometastases. Int J Radiat Oncol Biol Phys. 2022 12 01; 114(5):941-949. PMID: 35598799.
    Citations:    Fields:    
  13. Tjong MC, Mak RH, Louie AV. Trastuzumab Deruxtecan in Non-Small-Cell Lung Cancer. N Engl J Med. 2022 05 05; 386(18):1770. PMID: 35507495.
    Citations:    Fields:    Translation:Humans
  14. Ye Z, Qian JM, Hosny A, Zeleznik R, Plana D, Likitlersuang J, Zhang Z, Mak RH, Aerts HJWL, Kann BH. Deep Learning-based Detection of Intravenous Contrast Enhancement on CT Scans. Radiol Artif Intell. 2022 May; 4(3):e210285. PMID: 35652117; PMCID: PMC9152686.
    Citations:    
  15. Hu DY, Xu Y, Chen YH, Khosravi M, Lyatskaya Y, Bredfeldt JS, Hacker FL, Balboni TA, Spektor A, Cagney D, Mak R, Huynh MA. Less Time Is Less Motion: Analysis of Practical Efficiencies Gained With a Modified Workflow Integrating Planar kV Midimaging With CBCT for Spine Stereotactic Body Radiation Therapy. Adv Radiat Oncol. 2022 Sep-Oct; 7(5):100961. PMID: 35847546; PMCID: PMC9280020.
    Citations:    
  16. Leeman JE, Cagney DN, Mak RH, Huynh MA, Tanguturi SK, Singer L, Catalano P, Martin NE, D'Amico AV, Mouw KW, Nguyen PL, King MT, Han Z, Williams C, Huynh E. Magnetic Resonance-Guided Prostate Stereotactic Body Radiation Therapy With Daily Online Plan Adaptation: Results of a Prospective Phase 1 Trial and Supplemental Cohort. Adv Radiat Oncol. 2022 Sep-Oct; 7(5):100934. PMID: 35847547; PMCID: PMC9280019.
    Citations:    
  17. Tjong MC, Bitterman DS, Brantley K, Nohria A, Hoffmann U, Atkins KM, Mak RH. Major adverse cardiac event risk prediction model incorporating baseline Cardiac disease, Hypertension, and Logarithmic Left anterior descending coronary artery radiation dose in lung cancer (CHyLL). Radiother Oncol. 2022 04; 169:105-113. PMID: 35182687.
    Citations:    Fields:    Translation:Humans
  18. Huynh E, Boyle S, Campbell J, Penney J, Mak RH, Schoenfeld JD, Leeman JE, Williams CL. Technical note: Toward implementation of MR-guided radiation therapy for laryngeal cancer with healthy volunteer imaging and a custom MR-CT larynx phantom. Med Phys. 2022 Mar; 49(3):1814-1821. PMID: 35090060.
    Citations:    Fields:    Translation:Humans
  19. Schoenfeld JD, Giobbie-Hurder A, Ranasinghe S, Kao KZ, Lako A, Tsuji J, Liu Y, Brennick RC, Gentzler RD, Lee C, Hubbard J, Arnold SM, Abbruzzese JL, Jabbour SK, Uboha NV, Stephans KL, Johnson JM, Park H, Villaruz LC, Sharon E, Streicher H, Ahmed MM, Lyon H, Cibuskis C, Lennon N, Jhaveri A, Yang L, Altreuter J, Gunasti L, Weirather JL, Mak RH, Awad MM, Rodig SJ, Chen HX, Wu CJ, Monjazeb AM, Hodi FS. Durvalumab plus tremelimumab alone or in combination with low-dose or hypofractionated radiotherapy in metastatic non-small-cell lung cancer refractory to previous PD(L)-1 therapy: an open-label, multicentre, randomised, phase 2 trial. Lancet Oncol. 2022 02; 23(2):279-291. PMID: 35033226; PMCID: PMC8813905.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  20. Atkins KM, Weiss J, Zeleznik R, Bitterman DS, Chaunzwa TL, Huynh E, Guthier C, Kozono DE, Lewis JH, Tamarappoo BK, Nohria A, Hoffmann U, Aerts HJWL, Mak RH. Elevated Coronary Artery Calcium Quantified by a Validated Deep Learning Model From Lung Cancer Radiotherapy Planning Scans Predicts Mortality. JCO Clin Cancer Inform. 2022 01; 6:e2100095. PMID: 35084935.
    Citations:    Fields:    Translation:Humans
  21. Kim E, Bitterman DS, Kann BH, Mak RH, Moreno AC, Upadhyay VA, Warner JL, Zhang HM. Hidden in Plain Sight: Clinical Informaticians are the Oncology Subspecialists You Did Not Know You Needed. Clin Oncol (R Coll Radiol). 2022 02; 34(2):135-140. PMID: 34887151; PMCID: PMC8792333.
    Citations:    Fields:    Translation:Humans
  22. Bitterman DS, Selesnick P, Bredfeldt J, Williams CL, Guthier C, Huynh E, Kozono DE, Lewis JH, Cormack RA, Carpenter CM, Mak RH, Atkins KM. Dosimetric Planning Tradeoffs to Reduce Heart Dose Using Machine Learning-Guided Decision Support Software in Patients with Lung Cancer. Int J Radiat Oncol Biol Phys. 2022 03 15; 112(4):996-1003. PMID: 34774998.
    Citations:    Fields:    Translation:Humans
  23. Liu KX, Sierra-Davidson K, Tyan K, Orlina LT, Marcoux JP, Kann BH, Kozono DE, Mak RH, White A, Singer L. Surgical complications and clinical outcomes after dose-escalated trimodality therapy for non-small cell lung cancer in the era of intensity-modulated radiotherapy. Radiother Oncol. 2021 12; 165:44-51. PMID: 34695520; PMCID: PMC8688236.
    Citations:    Fields:    Translation:Humans
  24. Wei C, Qian PC, Boeck M, Bredfeldt JS, Blankstein R, Tedrow UB, Mak R, Zei PC. Cardiac stereotactic body radiation therapy for ventricular tachycardia: Current experience and technical gaps. J Cardiovasc Electrophysiol. 2021 11; 32(11):2901-2914. PMID: 34587335.
    Citations: 2     Fields:    Translation:Humans
  25. Rosenberg SA, Mak R, Kotecha R, Loo BW, Senan S. The Nordic-HILUS Trial: Ultracentral Lung Stereotactic Ablative Radiotherapy and a Narrow Therapeutic Window. J Thorac Oncol. 2021 10; 16(10):e79-e80. PMID: 34561039.
    Citations:    Fields:    Translation:Humans
  26. Qian PC, Quadros K, Aguilar M, Wei C, Boeck M, Bredfeldt J, Cochet H, Blankstein R, Mak R, Sauer WH, Tedrow UB, Zei PC. Substrate Modification Using Stereotactic Radioablation to Treat Refractory Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy. JACC Clin Electrophysiol. 2022 01; 8(1):49-58. PMID: 34364832.
    Citations: 2     Fields:    Translation:Humans
  27. Nobel JM, Puts S, Weiss J, Aerts HJWL, Mak RH, Robben SGF, Dekker ALAJ. T-staging pulmonary oncology from radiological reports using natural language processing: translating into a multi-language setting. Insights Imaging. 2021 Jun 10; 12(1):77. PMID: 34114076.
    Citations: 1     
  28. Talcott WJ, Miccio JA, Park HS, White AA, Kozono DE, Singer L, Sands JM, Sholl LM, Detterbeck FC, Mak RH, Decker RH, Kann BH. Rates of invasive disease and outcomes in NSCLC patients with biopsy suggestive of carcinoma in situ. Lung Cancer. 2021 07; 157:17-20. PMID: 34052704.
    Citations:    Fields:    Translation:Humans
  29. Whitaker J, Mak RH, Zei PC. Non-invasive ablation of arrhythmias with stereotactic ablative radiotherapy. Trends Cardiovasc Med. 2022 07; 32(5):287-296. PMID: 33951498.
    Citations:    Fields:    Translation:Humans
  30. Grant JM, Song WHC, Shajari S, Mak R, Meikle AT, Partovi N, Masri BA, Lau TTY. Safety of administering cefazolin versus other antibiotics in penicillin-allergic patients for surgical prophylaxis at a major Canadian teaching hospital. Surgery. 2021 09; 170(3):783-789. PMID: 33894984.
    Citations: 3     Fields:    Translation:Humans
  31. Elhalawani H, Mak R. Are Artificial Intelligence Challenges Becoming Radiology's New "Bee's Knees"? Radiol Artif Intell. 2021 May; 3(3):e210056. PMID: 34138989; PMCID: PMC8204138.
    Citations:    
  32. Atkins KM, Bitterman DS, Chaunzwa TL, Kozono DE, Baldini EH, Aerts HJWL, Tamarappoo BK, Hoffmann U, Nohria A, Mak RH. Mean Heart Dose Is an Inadequate Surrogate for Left Anterior Descending Coronary Artery Dose and the Risk of Major Adverse Cardiac Events in Lung Cancer Radiation Therapy. Int J Radiat Oncol Biol Phys. 2021 08 01; 110(5):1473-1479. PMID: 33713743.
    Citations: 2     Fields:    Translation:Humans
  33. Chaunzwa TL, Hosny A, Xu Y, Shafer A, Diao N, Lanuti M, Christiani DC, Mak RH, Aerts HJWL. Deep learning classification of lung cancer histology using CT images. Sci Rep. 2021 03 09; 11(1):5471. PMID: 33727623; PMCID: PMC7943565.
    Citations: 7     Fields:    Translation:Humans
  34. Zeleznik R, Weiss J, Taron J, Guthier C, Bitterman DS, Hancox C, Kann BH, Kim DW, Punglia RS, Bredfeldt J, Foldyna B, Eslami P, Lu MT, Hoffmann U, Mak R, Aerts HJWL. Deep-learning system to improve the quality and efficiency of volumetric heart segmentation for breast cancer. NPJ Digit Med. 2021 Mar 05; 4(1):43. PMID: 33674717.
    Citations: 1     
  35. Shi DD, Liu KX, Hacker F, Hanna GJ, Kwong RY, Cagney DN, Mak RH, Singer L. Development and Implementation of an Online Adaptive Stereotactic Body Radiation Therapy Workflow for Treatment of Intracardiac Metastasis. Pract Radiat Oncol. 2021 Jul-Aug; 11(4):e395-e401. PMID: 33556580.
    Citations:    Fields:    Translation:Humans
  36. Bitterman DS, Miller TA, Mak RH, Savova GK. Clinical Natural Language Processing for Radiation Oncology: A Review and Practical Primer. Int J Radiat Oncol Biol Phys. 2021 07 01; 110(3):641-655. PMID: 33545300.
    Citations: 2     Fields:    Translation:Humans
  37. Atkins KM, Chaunzwa TL, Lamba N, Bitterman DS, Rawal B, Bredfeldt J, Williams CL, Kozono DE, Baldini EH, Nohria A, Hoffmann U, Aerts HJWL, Mak RH. Association of Left Anterior Descending Coronary Artery Radiation Dose With Major Adverse Cardiac Events and Mortality in Patients With Non-Small Cell Lung Cancer. JAMA Oncol. 2021 Feb 01; 7(2):206-219. PMID: 33331883; PMCID: PMC7747040.
    Citations: 12     Fields:    Translation:Humans
  38. Atkins KM, Bitterman DS, Chaunzwa TL, Williams CL, Rahman R, Kozono DE, Baldini EH, Aerts HJWL, Tamarappoo BK, Hoffmann U, Nohria A, Mak RH. Statin Use, Heart Radiation Dose, and Survival in Locally Advanced Lung Cancer. Pract Radiat Oncol. 2021 Sep-Oct; 11(5):e459-e467. PMID: 33476841.
    Citations: 2     Fields:    Translation:Humans
  39. Boyle PJ, Huynh E, Boyle S, Campbell J, Penney J, Usta I, Neubauer Sugar E, Hacker F, Williams C, Cagney D, Mak R, Singer L. Use of a healthy volunteer imaging program to optimize clinical implementation of stereotactic MR-guided adaptive radiotherapy. Tech Innov Patient Support Radiat Oncol. 2020 Dec; 16:70-76. PMID: 33305025; PMCID: PMC7710639.
    Citations:    
  40. Soller L, Abrams EM, Carr S, Kapur S, Rex GA, Leo S, McHenry M, Vander Leek TK, Yeung J, Cook VE, Wong T, Hildebrand KJ, Mak R, Gerstner TV, Cameron SB, Chan ES. First Real-World Effectiveness Analysis of Preschool Peanut Oral Immunotherapy. J Allergy Clin Immunol Pract. 2021 03; 9(3):1349-1356.e1. PMID: 33221274.
    Citations: 6     Fields:    Translation:HumansAnimals
  41. Liu KX, Chen YH, Kozono D, Mak RH, Boyle PJ, Janeway KA, Mullen EA, Marcus KJ. Phase I/II Study of Stereotactic Body Radiation Therapy for Pulmonary Metastases in Pediatric Patients. Adv Radiat Oncol. 2020 Nov-Dec; 5(6):1267-1273. PMID: 33305087; PMCID: PMC7718514.
    Citations: 2     
  42. Sun R, Xu M, Li X, Gaynor S, Zhou H, Li Z, Bossé Y, Lam S, Tsao MS, Tardon A, Chen C, Doherty J, Goodman G, Bojesen SE, Landi MT, Johansson M, Field JK, Bickeböller H, Wichmann HE, Risch A, Rennert G, Arnold S, Wu X, Melander O, Brunnström H, Le Marchand L, Liu G, Andrew A, Duell E, Kiemeney LA, Shen H, Haugen A, Johansson M, Grankvist K, Caporaso N, Woll P, Dawn Teare M, Scelo G, Hong YC, Yuan JM, Lazarus P, Schabath MB, Aldrich MC, Albanes D, Mak R, Barbie D, Brennan P, Hung RJ, Amos CI, Christiani DC, Lin X. Integration of multiomic annotation data to prioritize and characterize inflammation and immune-related risk variants in squamous cell lung cancer. Genet Epidemiol. 2021 02; 45(1):99-114. PMID: 32924180; PMCID: PMC7855632.
    Citations: 1     Fields:    Translation:HumansCells
  43. Bitterman DS, Aerts HJWL, Mak RH. Approaching autonomy in medical artificial intelligence. Lancet Digit Health. 2020 09; 2(9):e447-e449. PMID: 33328110.
    Citations: 5     Fields:    Translation:Humans
  44. Huynh E, Hosny A, Guthier C, Bitterman DS, Petit SF, Haas-Kogan DA, Kann B, Aerts HJWL, Mak RH. Artificial intelligence in radiation oncology. Nat Rev Clin Oncol. 2020 12; 17(12):771-781. PMID: 32843739.
    Citations: 28     Fields:    Translation:Humans
  45. Mahmood U, Bang A, Chen YH, Mak RH, Lorch JH, Hanna GJ, Nishino M, Manuszak C, Thrash EM, Severgnini M, Sanborn M, Sridharan V, Margalit DN, Tishler RB, Busse PM, Willers H, Mamon HJ, Yoo HJ, Pai SI, Wirth LJ, Haddad RI, Chau NG, Schoenfeld JD. A Randomized Phase 2 Study of Pembrolizumab With or Without Radiation in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma. Int J Radiat Oncol Biol Phys. 2021 01 01; 109(1):134-144. PMID: 32781104; PMCID: PMC9361179.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  46. Kumana CR, Mak R, Kwong YL, Gill H. Resurrection of Oral Arsenic Trioxide for Treating Acute Promyelocytic Leukaemia: A Historical Account From Bedside to Bench to Bedside. Front Oncol. 2020; 10:1294. PMID: 32850403; PMCID: PMC7418518.
    Citations: 5     
  47. Qian PC, Quadros K, Aguilar M, Mak R, Zei P, Tedrow UB. Recurrent ventricular tachycardia arising at the treatment borderzone after stereotactic radioablation in a patient with ischemic cardiomyopathy. Europace. 2020 07 01; 22(7):1053. PMID: 32447365.
    Citations: 1     Fields:    Translation:Humans
  48. Thomas R, Chen YH, Hatabu H, Mak RH, Nishino M. Radiographic patterns of symptomatic radiation pneumonitis in lung cancer patients: Imaging predictors for clinical severity and outcome. Lung Cancer. 2020 07; 145:132-139. PMID: 32447116.
    Citations: 9     Fields:    Translation:Humans
  49. Herter-Sprie GS, Korideck H, Christensen CL, Herter JM, Rhee K, Berbeco RI, Bennett DG, Akbay EA, Kozono D, Mak RH, Makrigiorgos GM, Kimmelman AC, Wong KK. Author Correction: Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models. Nat Commun. 2020 Apr 09; 11(1):1835. PMID: 32273495; PMCID: PMC7145825.
    Citations:    Fields:    
  50. Kann BH, Johnson SB, Aerts HJWL, Mak RH, Nguyen PL. Changes in Length and Complexity of Clinical Practice Guidelines in Oncology, 1996-2019. JAMA Netw Open. 2020 03 02; 3(3):e200841. PMID: 32167566.
    Citations: 5     Fields:    Translation:Humans
  51. Bitterman DS, Cagney DN, Singer LL, Nguyen PL, Catalano PJ, Mak RH. Master Protocol Trial Design for Efficient and Rational Evaluation of Novel Therapeutic Oncology Devices. J Natl Cancer Inst. 2020 03 01; 112(3):229-237. PMID: 31504680.
    Citations: 5     Fields:    Translation:Humans
  52. Wei C, Qian P, Tedrow U, Mak R, Zei PC. Non-invasive Stereotactic Radioablation: A New Option for the Treatment of Ventricular Arrhythmias. Arrhythm Electrophysiol Rev. 2020 Feb 12; 8(4):285-293. PMID: 32685159; PMCID: PMC7358955.
    Citations: 4     
  53. Kamran SC, Coroller T, Milani N, Agrawal V, Baldini EH, Chen AB, Johnson BE, Kozono D, Franco I, Chopra N, Zeleznik R, Aerts HJWL, Mak R. The impact of quantitative CT-based tumor volumetric features on the outcomes of patients with limited stage small cell lung cancer. Radiat Oncol. 2020 Jan 14; 15(1):14. PMID: 31937336.
    Citations: 2     Fields:    Translation:Humans
  54. Atkins KM, Rawal B, Mak RH. Reply: Two Statistical Methodological Issues Worth of Attention for Survival Data Using Multivariable Models. J Am Coll Cardiol. 2019 10 01; 74(13):1739. PMID: 31558264.
    Citations:    Fields:    
  55. Hosny A, Aerts HJ, Mak RH. Handcrafted versus deep learning radiomics for prediction of cancer therapy response. Lancet Digit Health. 2019 07; 1(3):e106-e107. PMID: 33323257.
    Citations: 14     Fields:    Translation:Humans
  56. Mitra D, Chen YH, Li R, Hermann G, Atkins K, Kozono D, Baldini EH, Aizer A, Chukwueke U, Mak RH. EGFR mutant locally advanced non-small cell lung cancer is at increased risk of brain metastasis. Clin Transl Radiat Oncol. 2019 Sep; 18:32-38. PMID: 31341973; PMCID: PMC6612652.
    Citations: 3     
  57. Atkins KM, Rawal B, Chaunzwa TL, Lamba N, Bitterman DS, Williams CL, Kozono DE, Baldini EH, Chen AB, Nguyen PL, D'Amico AV, Nohria A, Hoffmann U, Aerts HJWL, Mak RH. Cardiac Radiation Dose, Cardiac Disease, and Mortality in Patients With Lung Cancer. J Am Coll Cardiol. 2019 06 18; 73(23):2976-2987. PMID: 31196455.
    Citations: 45     Fields:    Translation:HumansPHPublic Health
  58. Mak RH, Endres MG, Paik JH, Sergeev RA, Aerts H, Williams CL, Lakhani KR, Guinan EC. Use of Crowd Innovation to Develop an Artificial Intelligence-Based Solution for Radiation Therapy Targeting. JAMA Oncol. 2019 May 01; 5(5):654-661. PMID: 30998808; PMCID: PMC6512265.
    Citations: 18     Fields:    Translation:Humans
  59. Schoenfeld JD, Nishino M, Severgnini M, Manos M, Mak RH, Hodi FS. Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features. J Immunother Cancer. 2019 04 24; 7(1):112. PMID: 31014385.
    Citations: 32     Fields:    Translation:Humans
  60. Xu Y, Hosny A, Zeleznik R, Parmar C, Coroller T, Franco I, Mak RH, Aerts HJWL. Deep Learning Predicts Lung Cancer Treatment Response from Serial Medical Imaging. Clin Cancer Res. 2019 06 01; 25(11):3266-3275. PMID: 31010833; PMCID: PMC6548658.
    Citations: 94     Fields:    Translation:Humans
  61. Soller L, Abrams EM, Carr S, Kapur S, Rex GA, Leo S, Lidman PG, Yeung J, Vander Leek TK, McHenry M, Wong T, Cook VE, Hildebrand KJ, Gerstner TV, Mak R, Lee NJ, Cameron SB, Chan ES. First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy. J Allergy Clin Immunol Pract. 2019 Nov - Dec; 7(8):2759-2767.e5. PMID: 31002957.
    Citations: 16     Fields:    Translation:HumansAnimals
  62. Bi WL, Hosny A, Schabath MB, Giger ML, Birkbak NJ, Mehrtash A, Allison T, Arnaout O, Abbosh C, Dunn IF, Mak RH, Tamimi RM, Tempany CM, Swanton C, Hoffmann U, Schwartz LH, Gillies RJ, Huang RY, Aerts HJWL. Artificial intelligence in cancer imaging: Clinical challenges and applications. CA Cancer J Clin. 2019 03; 69(2):127-157. PMID: 30720861; PMCID: PMC6403009.
    Citations: 268     Fields:    Translation:Humans
  63. Zei PC, Mak R. Noninvasive Stereotactic Radioablation for Ventricular Tachycardia. Circulation. 2019 01 15; 139(3):322-324. PMID: 30586783.
    Citations: 3     Fields:    Translation:Humans
  64. Hosny A, Parmar C, Coroller TP, Grossmann P, Zeleznik R, Kumar A, Bussink J, Gillies RJ, Mak RH, Aerts HJWL. Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study. PLoS Med. 2018 11; 15(11):e1002711. PMID: 30500819; PMCID: PMC6269088.
    Citations: 125     Fields:    Translation:Humans
  65. Vasconcelos MA, Simões E Silva AC, Dias CS, Gomes IR, Carvalho RA, Figueiredo SV, Dumont TR, Oliveira MCL, Pinheiro SV, Mak RH, Oliveira EA. Posterior urethral valves: comparison of clinical outcomes between postnatal and antenatal cohorts. J Pediatr Urol. 2019 Apr; 15(2):167.e1-167.e8. PMID: 30554921.
    Citations:    Fields:    Translation:Humans
  66. Dou TH, Coroller TP, van Griethuysen JJM, Mak RH, Aerts HJWL. Peritumoral radiomics features predict distant metastasis in locally advanced NSCLC. PLoS One. 2018; 13(11):e0206108. PMID: 30388114.
    Citations: 35     Fields:    Translation:Humans
  67. Mak RH, Hermann G, Aerts HJ, Baldini EH, Chen AB, Kozono D, Rabin MS, Swanson SJ, Chen YH, Catalano P, Johnson BE, Jänne PA. Outcomes by EGFR, KRAS, and ALK Genotype After Combined Modality Therapy for Locally Advanced Non-Small-Cell Lung Cancer. JCO Precis Oncol. 2018 Nov; 2:1-18. PMID: 35135121.
    Citations:    Fields:    
  68. Bitterman DS, Zei PC, Mak RH. Radiation Safety and Cardiovascular Implantable Electronic Devices. Int J Radiat Oncol Biol Phys. 2018 10 01; 102(2):243-246. PMID: 30191855.
    Citations: 1     Fields:    Translation:Humans
  69. Hou Y, Hermann G, Lewis JH, Aerts HJ, Baldini EH, Chen AB, Colson YL, Hacker FL, Killoran JH, Kozono DE, Wagar M, Wee JO, Mak RH. Clinical Outcomes After Lung Stereotactic Body Radiation Therapy in Patients With or Without a Prior Lung Resection. Am J Clin Oncol. 2018 07; 41(7):695-701. PMID: 27819875.
    Citations: 5     Fields:    Translation:Humans
  70. Markmiller S, Soltanieh S, Server KL, Mak R, Jin W, Fang MY, Luo EC, Krach F, Yang D, Sen A, Fulzele A, Wozniak JM, Gonzalez DJ, Kankel MW, Gao FB, Bennett EJ, Lécuyer E, Yeo GW. Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell. 2018 01 25; 172(3):590-604.e13. PMID: 29373831; PMCID: PMC5969999.
    Citations: 267     Fields:    Translation:HumansAnimalsCells
  71. Diao K, Chen YH, Catalano PJ, Lee S, Milani N, Killoran JH, Baldini EH, Chen AB, Kozono DE, Mak RH. Radiation toxicity in patients with collagen vascular disease and intrathoracic malignancy treated with modern radiation techniques. Radiother Oncol. 2017 11; 125(2):301-309. PMID: 29102264.
    Citations: 3     Fields:    Translation:Humans
  72. Yip SSF, Parmar C, Kim J, Huynh E, Mak RH, Aerts HJWL. Impact of experimental design on PET radiomics in predicting somatic mutation status. Eur J Radiol. 2017 Dec; 97:8-15. PMID: 29153372.
    Citations: 16     Fields:    Translation:Humans
  73. Franco I, Chen YH, Chipidza F, Agrawal V, Romano J, Baldini E, Chen A, Colson Y, Hou Y, Kozono D, Wee J, Mak R. Use of frailty to predict survival in elderly patients with early stage non-small-cell lung cancer treated with stereotactic body radiation therapy. J Geriatr Oncol. 2018 03; 9(2):130-137. PMID: 28941581.
    Citations: 8     Fields:    Translation:Humans
  74. Martínez P, Mak RH, Oxnard GR. Targeted Therapy as an Alternative to Whole-Brain Radiotherapy in EGFR-Mutant or ALK-Positive Non-Small-Cell Lung Cancer With Brain Metastases. JAMA Oncol. 2017 Sep 01; 3(9):1274-1275. PMID: 28520828.
    Citations: 18     Fields:    Translation:Humans
  75. Aizer AA, Mak R, Alexander BM. Prophylactic cranial irradiation in patients with extensive-stage small cell lung cancer. Neuro Oncol. 2017 08 01; 19(8):1015-1016. PMID: 28854622; PMCID: PMC5570200.
    Citations:    Fields:    Translation:Humans
  76. Rios Velazquez E, Parmar C, Liu Y, Coroller TP, Cruz G, Stringfield O, Ye Z, Makrigiorgos M, Fennessy F, Mak RH, Gillies R, Quackenbush J, Aerts HJWL. Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer. Cancer Res. 2017 07 15; 77(14):3922-3930. PMID: 28566328; PMCID: PMC5528160.
    Citations: 129     Fields:    Translation:Humans
  77. Agrawal V, Coroller TP, Hou Y, Lee SW, Romano JL, Baldini EH, Chen AB, Kozono D, Swanson SJ, Wee JO, Aerts HJWL, Mak RH. Lymph node volume predicts survival but not nodal clearance in Stage IIIA-IIIB NSCLC. PLoS One. 2017; 12(4):e0174268. PMID: 28426673.
    Citations: 2     Fields:    Translation:Humans
  78. Wang M, Han J, Marcar L, Black J, Liu Q, Li X, Nagulapalli K, Sequist LV, Mak RH, Benes CH, Hong TS, Gurtner K, Krause M, Baumann M, Kang JX, Whetstine JR, Willers H. Radiation Resistance in KRAS-Mutated Lung Cancer Is Enabled by Stem-like Properties Mediated by an Osteopontin-EGFR Pathway. Cancer Res. 2017 04 15; 77(8):2018-2028. PMID: 28202526; PMCID: PMC5445902.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  79. Sundaramoorthy E, Leonard M, Mak R, Liao J, Fulzele A, Bennett EJ. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Mol Cell. 2017 Feb 16; 65(4):751-760.e4. PMID: 28132843; PMCID: PMC5321136.
    Citations: 121     Fields:    Translation:HumansCells
  80. Huynh E, Coroller TP, Narayan V, Agrawal V, Romano J, Franco I, Parmar C, Hou Y, Mak RH, Aerts HJ. Associations of Radiomic Data Extracted from Static and Respiratory-Gated CT Scans with Disease Recurrence in Lung Cancer Patients Treated with SBRT. PLoS One. 2017; 12(1):e0169172. PMID: 28046060.
    Citations: 40     Fields:    Translation:Humans
  81. Coroller TP, Agrawal V, Huynh E, Narayan V, Lee SW, Mak RH, Aerts HJWL. Radiomic-Based Pathological Response Prediction from Primary Tumors and Lymph Nodes in NSCLC. J Thorac Oncol. 2017 03; 12(3):467-476. PMID: 27903462.
    Citations: 78     Fields:    Translation:Humans
  82. Agrawal V, Coroller TP, Hou Y, Lee SW, Romano JL, Baldini EH, Chen AB, Jackman DM, Kozono D, Swanson SJ, Wee JO, Aerts HJ, Mak RH. Radiologic-pathologic correlation of response to chemoradiation in resectable locally advanced NSCLC. Lung Cancer. 2016 12; 102:1-8. PMID: 27987576.
    Citations: 8     Fields:    Translation:Humans
  83. Hou Y, Lee S, Agrawal V, Romano J, Baldini EH, Chen AB, Kozono DE, Killoran JH, Wagar M, Hacker FL, Aerts HJ, Lewis JH, Mak RH. Inter-scan and inter-observer tumour volume delineation variability on cone beam computed tomography in patients treated with stereotactic body radiation therapy for early-stage non-small cell lung cancer. J Med Imaging Radiat Oncol. 2017 Feb; 61(1):93-98. PMID: 27709803.
    Citations:    Fields:    Translation:Humans
  84. Yip SS, Kim J, Coroller TP, Parmar C, Velazquez ER, Huynh E, Mak RH, Aerts HJ. Associations Between Somatic Mutations and Metabolic Imaging Phenotypes in Non-Small Cell Lung Cancer. J Nucl Med. 2017 04; 58(4):569-576. PMID: 27688480; PMCID: PMC5373502.
    Citations: 65     Fields:    Translation:Humans
  85. Mak RH, Hunt D, Efstathiou JA, Heney NM, Jones CU, Lukka HR, Bahary JP, Patel M, Balogh A, Nabid A, Leibenhaut MH, Hamstra DA, Roof KS, Jeffrey Lee R, Gore EM, Sandler HM, Shipley WU. Acute and late urinary toxicity following radiation in men with an intact prostate gland or after a radical prostatectomy: A secondary analysis of RTOG 94-08 and 96-01. Urol Oncol. 2016 10; 34(10):430.e1-7. PMID: 27381895; PMCID: PMC5035191.
    Citations: 6     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  86. Huynh E, Coroller TP, Narayan V, Agrawal V, Hou Y, Romano J, Franco I, Mak RH, Aerts HJ. CT-based radiomic analysis of stereotactic body radiation therapy patients with lung cancer. Radiother Oncol. 2016 08; 120(2):258-66. PMID: 27296412.
    Citations: 61     Fields:    Translation:Humans
  87. Coroller T, Agrawal V, Narayan V, Lee S, Mak R, Aerts H. TU-D-207B-06: Pathological Response Prediction by Radiomic Data From Primary and Lymph Nodes in NSCLC. Med Phys. 2016 Jun; 43(6):3751. PMID: 28046592.
    Citations:    
  88. Huynh E, Coroller T, Narayan V, Agrawal V, Romano J, Franco I, Hou Y, Mak R, Aerts H. SU-F-R-52: A Comparison of the Performance of Radiomic Features From Free Breathing and 4DCT Scans in Predicting Disease Recurrence in Lung Cancer SBRT Patients. Med Phys. 2016 Jun; 43(6):3385. PMID: 28046768.
    Citations:    
  89. Coroller T, Yip S, Kim J, Lee S, Mak R, Aerts H. SU-D-207B-03: A PET-CT Radiomics Comparison to Predict Distant Metastasis in Lung Adenocarcinoma. Med Phys. 2016 Jun; 43(6):3349. PMID: 28047618.
    Citations:    
  90. Yip S, Kim J, Coroller T, Rios Velazquez E, Parmar C, Mak R, Aerts H. MO-DE-207B-01: JACK FOWLER JUNIOR INVESTIGATOR COMPETITION WINNER: Between Somatic Mutations and PET-Based Radiomic Features in Non-Small Cell Lung Cancer. Med Phys. 2016 Jun; 43(6):3704. PMID: 28048737.
    Citations:    
  91. Huynh E, Coroller T, Narayan V, Agrawal V, Hou Y, Romano J, Franco I, Mak R, Aerts H. SU-F-R-53: CT-Based Radiomics Analysis of Non-Small Cell Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy. Med Phys. 2016 Jun; 43(6):3385. PMID: 28048830.
    Citations:    
  92. Coroller TP, Agrawal V, Narayan V, Hou Y, Grossmann P, Lee SW, Mak RH, Aerts HJ. Radiomic phenotype features predict pathological response in non-small cell lung cancer. Radiother Oncol. 2016 06; 119(3):480-6. PMID: 27085484.
    Citations: 119     Fields:    Translation:Humans
  93. Agrawal V, Marcoux JP, Rabin MS, Vernovsky I, Wee JO, Mak RH. Case report of tracheobronchial squamous cell carcinoma treated with radiation therapy and concurrent chemotherapy. Adv Radiat Oncol. 2016 Apr-Jun; 1(2):127-131. PMID: 28740880; PMCID: PMC5506744.
    Citations: 1     
  94. Wu W, Parmar C, Grossmann P, Quackenbush J, Lambin P, Bussink J, Mak R, Aerts HJ. Exploratory Study to Identify Radiomics Classifiers for Lung Cancer Histology. Front Oncol. 2016; 6:71. PMID: 27064691; PMCID: PMC4811956.
    Citations: 141     
  95. Li R, Hermann G, Baldini E, Chen A, Jackman D, Kozono D, Nguyen P, Nohria A, Powell G, Mak R. Advanced nodal stage predicts venous thromboembolism in patients with locally advanced non-small cell lung cancer. Lung Cancer. 2016 06; 96:41-7. PMID: 27133748.
    Citations: 10     Fields:    Translation:Humans
  96. Coroller T, Grossmann P, Hou Y, Lee S, Mak R, Aerts H. SU-E-J-246: CT-Based Volumetric Features Are Associated with Somatic Mutations in Lung Cancer. Med Phys. 2015 Jun; 42(6):3322. PMID: 26127634.
    Citations:    
  97. Hou Y, Aileen C, Kozono D, Killoran J, Wagar M, Lee S, Hacker F, Aerts H, Lewis J, Mak R. SU-E-J-266: Cone Beam Computed Tomography (CBCT) Inter-Scan and Inter-Observer Tumor Volume Variability Assessment in Patients Treated with Stereotactic Body Radiation Therapy (SBRT) for Early Stage Non-Small Cell Lung Cancer (NSCLC). Med Phys. 2015 Jun; 42(6):3328. PMID: 26127657.
    Citations:    
  98. Coroller TP, Grossmann P, Hou Y, Rios Velazquez E, Leijenaar RT, Hermann G, Lambin P, Haibe-Kains B, Mak RH, Aerts HJ. CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma. Radiother Oncol. 2015 Mar; 114(3):345-50. PMID: 25746350.
    Citations: 280     Fields:    Translation:Humans
  99. Baldini EH, Richards WG, Gill RR, Goodman BM, Winfrey OK, Eisen HM, Mak RH, Chen AB, Kozono DE, Bueno R, Sugarbaker DJ. Updated patterns of failure after multimodality therapy for malignant pleural mesothelioma. J Thorac Cardiovasc Surg. 2015 May; 149(5):1374-81. PMID: 25772281; PMCID: PMC6042876.
    Citations: 27     Fields:    Translation:Humans
  100. Hurwitz M, Williams CL, Mishra P, Rottmann J, Dhou S, Wagar M, Mannarino EG, Mak RH, Lewis JH. Generation of fluoroscopic 3D images with a respiratory motion model based on an external surrogate signal. Phys Med Biol. 2015 Jan 21; 60(2):521-35. PMID: 25548999.
    Citations: 2     Fields:    Translation:Humans
  101. Herter-Sprie GS, Korideck H, Christensen CL, Herter JM, Rhee K, Berbeco RI, Bennett DG, Akbay EA, Kozono D, Mak RH, Mike Makrigiorgos G, Kimmelman AC, Wong KK. Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models. Nat Commun. 2014 Dec 18; 5:5870. PMID: 25519892; PMCID: PMC4271540.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  102. Mak RH, Hunt D, Shipley WU, Efstathiou JA, Tester WJ, Hagan MP, Kaufman DS, Heney NM, Zietman AL. Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233. J Clin Oncol. 2014 Dec 01; 32(34):3801-9. PMID: 25366678.
    Citations: 101     Fields:    Translation:Humans
  103. Mak RH, Hermann G, Lewis JH, Aerts HJ, Baldini EH, Chen AB, Colson YL, Hacker FH, Kozono D, Wee JO, Chen YH, Catalano PJ, Wong KK, Sher DJ. Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer. Clin Lung Cancer. 2015 Jan; 16(1):24-32. PMID: 25450872.
    Citations: 34     Fields:    Translation:Humans
  104. Mishra P, Li R, Mak RH, Rottmann J, Bryant JH, Williams CL, Berbeco RI, Lewis JH. An initial study on the estimation of time-varying volumetric treatment images and 3D tumor localization from single MV cine EPID images. Med Phys. 2014 Aug; 41(8):081713. PMID: 25086523.
    Citations: 6     Fields:    Translation:Humans
  105. Parmar C, Rios Velazquez E, Leijenaar R, Jermoumi M, Carvalho S, Mak RH, Mitra S, Shankar BU, Kikinis R, Haibe-Kains B, Lambin P, Aerts HJ. Robust Radiomics feature quantification using semiautomatic volumetric segmentation. PLoS One. 2014; 9(7):e102107. PMID: 25025374.
    Citations: 217     Fields:    Translation:Humans
  106. Gray PJ, Mak RH, Yeap BY, Cryer SK, Pinnell NE, Christianson LW, Sher DJ, Arvold ND, Baldini EH, Chen AB, Kozono DE, Swanson SJ, Jackman DM, Alexander BM. Aggressive therapy for patients with non-small cell lung carcinoma and synchronous brain-only oligometastatic disease is associated with long-term survival. Lung Cancer. 2014 Aug; 85(2):239-44. PMID: 24974152.
    Citations: 35     Fields:    Translation:Humans
  107. Coroller T, Grossman P, Rios E, Mak R, Aerts H. WE-E-17A-04: CT Based Radiomics Data Predicts for Nodal Involvement and Overall Survival in NSCLC. Med Phys. 2014 Jun; 41(6):508. PMID: 28037615.
    Citations:    
  108. Parikh RB, Cronin AM, Kozono DE, Oxnard GR, Mak RH, Jackman DM, Lo PC, Baldini EH, Johnson BE, Chen AB. Definitive primary therapy in patients presenting with oligometastatic non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014 Jul 15; 89(4):880-7. PMID: 24867533.
    Citations: 58     Fields:    Translation:Humans
  109. Coroller TP, Mak RH, Lewis JH, Baldini EH, Chen AB, Colson YL, Hacker FL, Hermann G, Kozono D, Mannarino E, Molodowitch C, Wee JO, Sher DJ, Killoran JH. Low incidence of chest wall pain with a risk-adapted lung stereotactic body radiation therapy approach using three or five fractions based on chest wall dosimetry. PLoS One. 2014; 9(4):e94859. PMID: 24728448.
    Citations: 12     Fields:    Translation:Humans
  110. Velazquez ER, Parmar C, Jermoumi M, Mak RH, van Baardwijk A, Fennessy FM, Lewis JH, De Ruysscher D, Kikinis R, Lambin P, Aerts HJ. Volumetric CT-based segmentation of NSCLC using 3D-Slicer. Sci Rep. 2013 Dec 18; 3:3529. PMID: 24346241.
    Citations: 64     Fields:    Translation:Humans
  111. Williams CL, Mishra P, Seco J, St James S, Mak RH, Berbeco RI, Lewis JH. A mass-conserving 4D XCAT phantom for dose calculation and accumulation. Med Phys. 2013 Jul; 40(7):071728. PMID: 23822432.
    Citations: 4     Fields:    Translation:Humans
  112. Coroller T, Lewis J, Mak R, Chen A, Hacker F, Kozono D, Mannarino E, Molodowitch C, Killoran J. SU-E-T-694: Correlation Between Geometric Information and Dose Fractionation in Lung SBRT Treatment Plans. Med Phys. 2013 Jun; 40(6Part21):365-366. PMID: 28519454.
    Citations:    
  113. Williams C, Seco J, Mishra P, St James S, Mak R, Berbeco R, Lewis J. SU-E-J-29: Assessing the Dosimetric Effects of Tumor Tracking During Irregular Respiration Using a Mass-Conserving XCAT Phantom. Med Phys. 2013 Jun; 40(6Part7):156. PMID: 28519880.
    Citations:    
  114. Lewis J, Mamata H, Tokuda J, Mishra P, Hermann G, Hatabu H, Nishino M, Mak R. TH-C-141-08: A Feasibility Study of the Utility of Dynamic Contrast-Enhanced MRI for Treatment Planning and Monitoring Treatment Response in Lung Stereotactic Body Radiation Therapy. Med Phys. 2013 Jun; 40(6Part33):540. PMID: 28519198.
    Citations:    
  115. Williams C, Mishra P, Seco J, St James S, Wagar M, Mak R, Berbeco R, Lewis J. SU-C-141-07: A Mass-Conserving 4D XCAT Phantom Enabling Normal Tissue Deformable Dose Accumulation. Med Phys. 2013 Jun; 40(6Part2):93. PMID: 28518311.
    Citations:    
  116. Mishra P, Li R, James SS, Mak RH, Williams CL, Yue Y, Berbeco RI, Lewis JH. Evaluation of 3D fluoroscopic image generation from a single planar treatment image on patient data with a modified XCAT phantom. Phys Med Biol. 2013 Feb 21; 58(4):841-58. PMID: 23337614.
    Citations: 6     Fields:    Translation:Humans
  117. Lewis J, Mak R, Molodowitch C, Mannarino E, Baldini E, Chen A, Kozono D, Sher D, Hacker F, Killoran J. TU-E-BRB-02: A Decision Support Tool for SBRT Planning Using a Searchable DVH Database. Med Phys. 2012 Jun; 39(6Part24):3908. PMID: 28518686.
    Citations:    Fields:    
  118. Mishra P, Li R, St James S, Yue Y, Mak R, Berbeco R, Lewis J. SU-E-J-126: Generation of Fluoroscopic 3D Images Using Single X-Ray Projections on Realistic Modified XCAT Phantom Data. Med Phys. 2012 Jun; 39(6Part8):3681. PMID: 28518907.
    Citations: 1     Fields:    
  119. Mak RH, Hunt D, Shipley WU, Efstathiou JA, Tester WJ, Hagan MP, Kaufman DS, Heney NM, Zietman AL. Long-term outcomes in patients with muscle-invasive bladder cancer after bladder-preserving combined-modality therapy: A pooled analysis of RTOG 8802, 8903, 9506, 9706, 9906, and 0233. J Clin Oncol. 2012 Feb 10; 30(5_suppl):264. PMID: 28143313.
    Citations:    
  120. Mak RH, Alexander BM, Asomaning K, Heist RS, Liu CY, Su L, Zhai R, Ancukiewicz M, Napolitano B, Niemierko A, Willers H, Choi NC, Christiani DC. A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy. Cancer. 2012 Jul 15; 118(14):3654-65. PMID: 22144047; PMCID: PMC3312983.
    Citations: 13     Fields:    Translation:Humans
  121. Alexander BM, Wang XZ, Niemierko A, Weaver DT, Mak RH, Roof KS, Fidias P, Wain J, Choi NC. DNA repair biomarkers predict response to neoadjuvant chemoradiotherapy in esophageal cancer. Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):164-71. PMID: 22000749.
    Citations: 21     Fields:    Translation:HumansCells
  122. Mak RH, Doran E, Muzikansky A, Kang J, Neal JW, Baldini EH, Choi NC, Willers H, Jackman DM, Sequist LV. Outcomes after combined modality therapy for EGFR-mutant and wild-type locally advanced NSCLC. Oncologist. 2011; 16(6):886-95. PMID: 21632451.
    Citations: 23     Fields:    Translation:Humans
  123. Mak RH, Digumarthy SR, Muzikansky A, Engelman JA, Shepard JA, Choi NC, Sequist LV. Role of 18F-fluorodeoxyglucose positron emission tomography in predicting epidermal growth factor receptor mutations in non-small cell lung cancer. Oncologist. 2011; 16(3):319-26. PMID: 21339258.
    Citations: 37     Fields:    Translation:Humans
  124. Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011 Jan 21; 144(2):296-309. PMID: 21241896.
    Citations: 463     Fields:    Translation:Humans
  125. Mak RH, McCarthy EP, Das P, Hong TS, Mamon HJ, Hoffman KE. Adoption of preoperative radiation therapy for rectal cancer from 2000 to 2006: a Surveillance, Epidemiology, and End Results Patterns-of-Care Study. Int J Radiat Oncol Biol Phys. 2011 Jul 15; 80(4):978-84. PMID: 20961695.
    Citations: 9     Fields:    Translation:Humans
  126. Mak RH, Halasz LM, Tanaka CK, Ancukiewicz M, Schultz DJ, Russell AH, Viswanathan AN. Outcomes after radiation therapy with concurrent weekly platinum-based chemotherapy or every-3-4-week 5-fluorouracil-containing regimens for squamous cell carcinoma of the vulva. Gynecol Oncol. 2011 Jan; 120(1):101-7. PMID: 20950845.
    Citations: 10     Fields:    Translation:Humans
  127. Mak KS, Lee LK, Mak RH, Wang S, Pile-Spellman J, Abrahm JL, Prigerson HG, Balboni TA. Incidence and treatment patterns in hospitalizations for malignant spinal cord compression in the United States, 1998-2006. Int J Radiat Oncol Biol Phys. 2011 Jul 01; 80(3):824-31. PMID: 20630663.
    Citations: 20     Fields:    Translation:Humans
  128. Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12617-22. PMID: 20616024.
    Citations: 93     Fields:    Translation:Humans
  129. Mak RH, Mamon HJ, Ryan DP, Miyamoto DT, Ancukiewicz M, Kobayashi WK, Willett CG, Choi NC, Blaszkowsky LS, Hong TS. Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older. Dis Esophagus. 2010 May; 23(4):316-23. PMID: 19788436.
    Citations: 16     Fields:    Translation:Humans
  130. Dietschy T, Shevelev I, Pena-Diaz J, Hühn D, Kuenzle S, Mak R, Miah MF, Hess D, Fey M, Hottiger MO, Janscak P, Stagljar I. p300-mediated acetylation of the Rothmund-Thomson-syndrome gene product RECQL4 regulates its subcellular localization. J Cell Sci. 2009 Apr 15; 122(Pt 8):1258-67. PMID: 19299466.
    Citations: 23     Fields:    Translation:HumansCells
  131. Mak RH, Zietman AL, Heney NM, Kaufman DS, Shipley WU. Bladder preservation: optimizing radiotherapy and integrated treatment strategies. BJU Int. 2008 Nov; 102(9 Pt B):1345-53. PMID: 19035903.
    Citations: 11     Fields:    Translation:Humans
  132. Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol. 2008 Aug 01; 181(3):1859-68. PMID: 18641323; PMCID: PMC3771862.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  133. Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008 Jun; 14(6):843-53. PMID: 18539114; PMCID: PMC2688789.
    Citations: 159     Fields:    Translation:HumansAnimalsCells
  134. Ebert BL, Galili N, Tamayo P, Bosco J, Mak R, Pretz J, Tanguturi S, Ladd-Acosta C, Stone R, Golub TR, Raza A. An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome. PLoS Med. 2008 Feb; 5(2):e35. PMID: 18271621.
    Citations: 61     Fields:    Translation:HumansCells
  135. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature. 2005 Jun 09; 435(7043):834-8. PMID: 15944708.
    Citations: 3929     Fields:    Translation:HumansAnimals
  136. Ebert BL, Lee MM, Pretz JL, Subramanian A, Mak R, Golub TR, Sieff CA. An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. Blood. 2005 Jun 15; 105(12):4620-6. PMID: 15755903; PMCID: PMC1895002.
    Citations: 34     Fields:    Translation:HumansCells
  137. De Bacquer D, Pelfrene E, Clays E, Mak R, Moreau M, de Smet P, Kornitzer M, De Backer G. Perceived job stress and incidence of coronary events: 3-year follow-up of the Belgian Job Stress Project cohort. Am J Epidemiol. 2005 Mar 01; 161(5):434-41. PMID: 15718479.
    Citations: 38     Fields:    Translation:Humans
  138. Leung AY, Mak R, Lie AK, Yuen KY, Cheng VC, Liang R, Kwong YL. Clinicopathological features and risk factors of clinically overt haemorrhagic cystitis complicating bone marrow transplantation. Bone Marrow Transplant. 2002 Mar; 29(6):509-13. PMID: 11960271.
    Citations: 23     Fields:    Translation:HumansCells
  139. Cromheecke ME, Levi M, Colly LP, de Mol BJ, Prins MH, Hutten BA, Mak R, Keyzers KC, Büller HR. Oral anticoagulation self-management and management by a specialist anticoagulation clinic: a randomised cross-over comparison. Lancet. 2000 Jul 08; 356(9224):97-102. PMID: 10963245.
    Citations: 59     Fields:    Translation:HumansCTClinical Trials
  140. Rahman MA, Mak R, Ayad H, Smith A, Maclean N. Expression of a novel piscine growth hormone gene results in growth enhancement in transgenic tilapia (Oreochromis niloticus). Transgenic Res. 1998 Sep; 7(5):357-69. PMID: 9859224.
    Citations: 32     Fields:    Translation:AnimalsCells
  141. Alfrey EJ, Salvatierra O, Tanney DC, Mak R, Scandling JD, Dafoe DC, Hammer GB, Orlandi PD, Page L, Conley SB. Bladder augmentation can be problematic with renal failure and transplantation. Pediatr Nephrol. 1997 Dec; 11(6):672-5. PMID: 9438639.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  142. Mak RH. Amelioration of hypertension and insulin resistance by 1,25-dihydroxycholecalciferol in hemodialysis patients. Pediatr Nephrol. 1992 Jul; 6(4):345-8. PMID: 1498003.
    Citations: 16     Fields:    Translation:Humans
  143. Mak RH. Intravenous 1,25 dihydroxycholecalciferol corrects glucose intolerance in hemodialysis patients. Kidney Int. 1992 Apr; 41(4):1049-54. PMID: 1513086.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  144. Mak RH, DeFronzo RA. Glucose and insulin metabolism in uremia. Nephron. 1992; 61(4):377-82. PMID: 1501732.
    Citations: 34     Fields:    Translation:HumansAnimals
  145. Mak RH. Insulin secretion in uremia: effect of parathyroid hormone and vitamin D metabolites. Kidney Int Suppl. 1989 Nov; 27:S227-30. PMID: 2699996.
    Citations: 2     Fields:    Translation:Humans
  146. Mak RH. Carbohydrate metabolism in uremia. Pediatr Nephrol. 1989 Apr; 3(2):201-8. PMID: 2701869.
    Citations: 1     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.