Harvard Catalyst Profiles

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Michael Jerome Whalen, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS096550 (WHALEN, MICHAEL J) Jul 1, 2018 - Mar 31, 2022
    NIH/NINDS
    Mechanisms of cognitive dysfunction after repetitive closed head injury in adolescent mice
    Role: Principal Investigator
  2. R21HD086385 (WHALEN, MICHAEL J) Sep 1, 2016 - Aug 31, 2018
    NIH/NICHD
    Understanding Repetitive Concussion
    Role: Principal Investigator
  3. R03NS086631 (WHALEN, MICHAEL J) Jan 1, 2014 - Dec 31, 2015
    NIH/NINDS
    Characterization of the Brain and Serum Metabolome in Mouse Models of Concussion
    Role: Principal Investigator
  4. R21NS075226 (WHALEN, MICHAEL J) Apr 1, 2012 - Mar 31, 2014
    NIH/NINDS
    Development of a repetitive concussion traumatic brain injury model
    Role: Principal Investigator
  5. R01NS071072 (WHALEN, MICHAEL J) Mar 1, 2012 - Feb 28, 2017
    NIH/NINDS
    Plasmalemma permeability and necroptosis: New targets for intracerebral hemo
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Takizawa T, Qin T, Lopes de Morais A, Sugimoto K, Chung JY, Morsett L, Mulder I, Fischer P, Suzuki T, Anzabi M, Böhm M, Qu WS, Yanagisawa T, Hickman S, Khoury JE, Whalen MJ, Harriott AM, Chung DY, Ayata C. Non-invasively triggered spreading depolarizations induce a rapid pro-inflammatory response in cerebral cortex. J Cereb Blood Flow Metab. 2019 Jun 26; 271678X19859381. PMID: 31242047.
    Citations:    
  2. Sîrbulescu RF, Chung JY, Edmiston WJ, Poznansky SA, Poznansky MC, Whalen MJ. Intraparenchymal Application of Mature B Lymphocytes Improves Structural and Functional Outcome after Contusion Traumatic Brain Injury. J Neurotrauma. 2019 May 23. PMID: 30997843.
    Citations:    
  3. Koenig JB, Cantu D, Low C, Sommer M, Noubary F, Croker D, Whalen M, Kong D, Dulla CG. Glycolytic inhibitor 2-deoxyglucose prevents cortical hyperexcitability after traumatic brain injury. JCI Insight. 2019 Apr 30; 5. PMID: 31038473.
    Citations:    
  4. Tang-Schomer MD, Kaplan DL, Whalen MJ. Film interface for drug testing for delivery to cells in culture and in the brain. Acta Biomater. 2019 Mar 02. PMID: 30836199.
    Citations:    
  5. Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2019 Mar 01; 29(3):1150-1161. PMID: 29425263.
    Citations: 2     Fields:    
  6. Liaudanskaya V, Jgamadze D, Berk AN, Bischoff DJ, Gu BJ, Hawks-Mayer H, Whalen MJ, Chen HI, Kaplan DL. Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats. Biomaterials. 2019 Feb; 192:510-522. PMID: 30529870.
    Citations:    Fields:    
  7. McGill M, Raol N, Gipson KS, Bowe SN, Fulk-Logan J, Nourmahnad A, Chung JY, Whalen MJ, Kaplan DL, Hartnick CJ. Preclinical assessment of resorbable silk splints for the treatment of pediatric tracheomalacia. Laryngoscope. 2018 Nov 08. PMID: 30408198.
    Citations:    Fields:    
  8. Chung JY, Krapp N, Wu L, Lule S, McAllister LM, Edmiston WJ, Martin S, Levy E, Songtachalert T, Sherwood JS, Buckley EM, Sanders B, Izzy S, Hickman S, Guo S, Lok J, El Khoury J, Lo EH, Kaplan D, Whalen MJ. Interleukin-1 Receptor 1 Deletion in Focal and Diffuse Experimental Traumatic Brain Injury in Mice. J Neurotrauma. 2019 Jan 15; 36(2):370-379. PMID: 29768967.
    Citations:    Fields:    
  9. Wu L, Chung JY, Saith S, Tozzi L, Buckley EM, Sanders B, Franceschini MA, Lule S, Izzy S, Lok J, Edmiston WJ, McAllister LM, Mebane S, Jin G, Lu J, Sherwood JS, Willwerth S, Hickman S, Khoury JE, Lo EH, Kaplan D, Whalen MJ. Repetitive head injury in adolescent mice: A role for vascular inflammation. J Cereb Blood Flow Metab. 2018 07 13; 271678X18786633. PMID: 30001646.
    Citations: 1     Fields:    
  10. Akhter M, Qin T, Fischer P, Sadeghian H, Kim HH, Whalen MJ, Goldstein JN, Ayata C. Rho-kinase inhibitors do not expand hematoma volume in acute experimental intracerebral hemorrhage. Ann Clin Transl Neurol. 2018 Jun; 5(6):769-776. PMID: 29928660.
    Citations:    
  11. Badani KK, Reddy BN, Moskowitz EJ, Paulucci DJ, Beksac AT, Martini A, Whalen MJ, Skarecky DW, Huynh LM, Ahlering TE. Lymph node yield during radical prostatectomy does not impact rate of biochemical recurrence in patients with seminal vesicle invasion and node-negative disease. Urol Oncol. 2018 Jun; 36(6):310.e1-310.e6. PMID: 29625782.
    Citations:    Fields:    Translation:Humans
  12. Whalen MJ, Pak JS, Lascano D, Ahlborn D, Matulay JT, McKiernan JM, Benson MC, Wenske S. Oncologic Outcomes of Definitive Treatments for Low- and Intermediate-Risk Prostate Cancer After a Period of Active Surveillance. Clin Genitourin Cancer. 2018 04; 16(2):e425-e435. PMID: 29113772.
    Citations:    Fields:    
  13. Jassam YN, Izzy S, Whalen M, McGavern DB, El Khoury J. Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift. Neuron. 2017 Sep 13; 95(6):1246-1265. PMID: 28910616.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  14. Lule S, Wu L, McAllister LM, Edmiston WJ, Chung JY, Levy E, Zheng Y, Gough PJ, Bertin J, Degterev A, Lo EH, Whalen MJ. Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice. Stroke. 2017 09; 48(9):2549-2556. PMID: 28765287.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Cheng C, Yu Z, Zhao S, Liao Z, Xing C, Jiang Y, Yang YG, Whalen MJ, Lo EH, Sun X, Wang X. Thrombospondin-1 Gene Deficiency Worsens the Neurological Outcomes of Traumatic Brain Injury in Mice. Int J Med Sci. 2017; 14(10):927-936. PMID: 28924363.
    Citations:    Fields:    Translation:AnimalsCells
  16. Wang Q, Yuan J, Yu Z, Lin L, Jiang Y, Cao Z, Zhuang P, Whalen MJ, Song B, Wang XJ, Li X, Lo EH, Xu Y, Wang X. FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice. Mol Neurobiol. 2018 Jun; 55(6):4702-4717. PMID: 28712011.
    Citations: 2     Fields:    
  17. Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A. Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-ß Synthesis Induced by Lipopolysaccharide. J Immunol. 2017 06 01; 198(11):4435-4447. PMID: 28461567.
    Citations: 7     Fields:    Translation:AnimalsCells
  18. Zhao S, Yu Z, Liu Y, Bai Y, Jiang Y, van Leyen K, Yang YG, Lok JM, Whalen MJ, Lo EH, Wang X. CD47 deficiency improves neurological outcomes of traumatic brain injury in mice. Neurosci Lett. 2017 03 16; 643:125-130. PMID: 27931776.
    Citations:    Fields:    Translation:Animals
  19. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  20. McAvoy KM, Scobie KN, Berger S, Russo C, Guo N, Decharatanachart P, Vega-Ramirez H, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A. Modulating Neuronal Competition Dynamics in the Dentate Gyrus to Rejuvenate Aging Memory Circuits. Neuron. 2016 Sep 21; 91(6):1356-1373. PMID: 27593178.
    Citations: 18     Fields:    Translation:AnimalsCells
  21. Paulucci DJ, Rosen DC, Sfakianos JP, Whalen MJ, Abaza R, Eun DD, Krane LS, Hemal AK, Badani KK. Selective arterial clamping does not improve outcomes in robot-assisted partial nephrectomy: a propensity-score analysis of patients without impaired renal function. BJU Int. 2017 03; 119(3):430-435. PMID: 27480607.
    Citations: 3     Fields:    Translation:Humans
  22. Najjar M, Saleh D, Zelic M, Nogusa S, Shah S, Tai A, Finger JN, Polykratis A, Gough PJ, Bertin J, Whalen M, Pasparakis M, Balachandran S, Kelliher M, Poltorak A, Degterev A. RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity. 2016 07 19; 45(1):46-59. PMID: 27396959.
    Citations: 25     Fields:    Translation:AnimalsCells
  23. Belkind-Gerson J, Hotta R, Whalen M, Nayyar N, Nagy N, Cheng L, Zuckerman A, Goldstein AM, Dietrich J. Engraftment of enteric neural progenitor cells into the injured adult brain. BMC Neurosci. 2016 Jan 25; 17:5. PMID: 26810757.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  24. Kalish BT, Whalen MJ. Weight Drop Models in Traumatic Brain Injury. Methods Mol Biol. 2016; 1462:193-209. PMID: 27604720.
    Citations: 1     Fields:    Translation:HumansAnimals
  25. Pagano MJ, Whalen MJ, Paulucci DJ, Reddy BN, Matulay JT, Rothberg M, Scarberry K, Patel T, Shapiro EY, RoyChoudhury A, McKiernan J, Benson MC, Badani KK. Predictors of biochemical recurrence in pT3b prostate cancer after radical prostatectomy without adjuvant radiotherapy. Prostate. 2016 Feb; 76(2):226-34. PMID: 26481325.
    Citations: 2     Fields:    Translation:Humans
  26. Murphy SA, Bell MJ, Clark ME, Whalen MJ, Noviski N. Pediatric Neurocritical Care: A Short Survey of Current Perceptions and Practices. Neurocrit Care. 2015 Oct; 23(2):149-58. PMID: 25693892.
    Citations: 1     Fields:    Translation:Humans
  27. Paulucci DJ, Whalen MJ, Badani KK. Analysis of the Transperitoneal Approach to Robot-Assisted Laparoscopic Partial Nephrectomy for the Treatment of Anterior and Posterior Renal Masses. J Laparoendosc Adv Surg Tech A. 2015 Nov; 25(11):880-5. PMID: 26368056.
    Citations:    Fields:    Translation:Humans
  28. Smith DH, Hicks RR, Johnson VE, Bergstrom DA, Cummings DM, Noble LJ, Hovda D, Whalen M, Ahlers ST, LaPlaca M, Tortella FC, Duhaime AC, Dixon CE. Pre-Clinical Traumatic Brain Injury Common Data Elements: Toward a Common Language Across Laboratories. J Neurotrauma. 2015 Nov 15; 32(22):1725-35. PMID: 26058402.
    Citations: 17     Fields:    Translation:HumansAnimalsPHPublic Health
  29. Whalen MJ, Shapiro EY, Rothberg MB, Turk AT, Woldu SL, Roy Choudhury A, Patel T, Badani KK. Close surgical margins after radical prostatectomy mimic biochemical recurrence rates of positive margins. Urol Oncol. 2015 Nov; 33(11):494.e9-494.e14. PMID: 26259665.
    Citations: 2     Fields:    Translation:Humans
  30. Buckley EM, Miller BF, Golinski JM, Sadeghian H, McAllister LM, Vangel M, Ayata C, Meehan WP, Franceschini MA, Whalen MJ. Decreased microvascular cerebral blood flow assessed by diffuse correlation spectroscopy after repetitive concussions in mice. J Cereb Blood Flow Metab. 2015 Dec; 35(12):1995-2000. PMID: 26154866.
    Citations: 4     Fields:    Translation:Animals
  31. Dilekoz E, Houben T, Eikermann-Haerter K, Balkaya M, Lenselink AM, Whalen MJ, Spijker S, Ferrari MD, van den Maagdenberg AM, Ayata C. Migraine mutations impair hippocampal learning despite enhanced long-term potentiation. J Neurosci. 2015 Feb 25; 35(8):3397-402. PMID: 25716839.
    Citations: 4     Fields:    Translation:Animals
  32. Sierra-Mercado D, McAllister LM, Lee CC, Milad MR, Eskandar EN, Whalen MJ. Controlled cortical impact before or after fear conditioning does not affect fear extinction in mice. Brain Res. 2015 May 05; 1606:133-41. PMID: 25721797.
    Citations: 2     Fields:    Translation:Animals
  33. Blasi F, Whalen MJ, Ayata C. Lasting pure-motor deficits after focal posterior internal capsule white-matter infarcts in rats. J Cereb Blood Flow Metab. 2015 Jun; 35(6):977-84. PMID: 25649992.
    Citations: 7     Fields:    Translation:AnimalsCells
  34. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8. PMID: 25475543.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Whalen MJ. Cerebrovascular autoregulation in diabetic ketoacidosis: time to go with the (microvascular cerebral blood) flow! Pediatr Crit Care Med. 2014 Oct; 15(8):779-80. PMID: 25280150.
    Citations:    Fields:    Translation:Humans
  36. Matilsky D, Lewiss RE, Whalen M, Saul T. Fournier's gangrene. Case report. Med Ultrason. 2014 Sep; 16(3):262-3. PMID: 25110769.
    Citations:    Fields:    Translation:Humans
  37. Zhu X, Park J, Golinski J, Qiu J, Khuman J, Lee CC, Lo EH, Degterev A, Whalen MJ. Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice. J Cereb Blood Flow Metab. 2014 Sep; 34(9):1531-9. PMID: 24938400.
    Citations: 7     Fields:    Translation:AnimalsCells
  38. Miller BF, Keles E, Tien L, Zhang J, Kaplan D, Lo EH, Whalen MJ. The pharmacokinetics and pharmacodynamics of Kollidon VA64 dissociate its protective effects from membrane resealing after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2014 Aug; 34(8):1347-53. PMID: 24824916.
    Citations: 3     Fields:    Translation:Animals
  39. Tang-Schomer MD, Hu X, Tupaj M, Tien LW, Whalen M, Omenetto F, Kaplan DL. Film-based Implants for Supporting Neuron-Electrode Integrated Interfaces for The Brain. Adv Funct Mater. 2014 Apr 02; 24(13):1938-1948. PMID: 25386113.
    Citations: 4     
  40. Mannix R, Meehan WP, Feany M, Grant PE, Mandeville J, Kaplan DL, Whalen M. Genetic influences and neuropathological sequelae of repetitive brain injury. Reply. Ann Neurol. 2014 Apr; 75(4):618. PMID: 24242978.
    Citations:    Fields:    Translation:Animals
  41. Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis. 2014 Feb 27; 5:e1084. PMID: 24577082.
    Citations: 23     Fields:    Translation:AnimalsCells
  42. Schaefer JH, Leung W, Wu L, Van Cott EM, Lok J, Whalen M, van Leyen K, Lauer A, van Ryn J, Lo EH, Foerch C. Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation. J Cereb Blood Flow Metab. 2014 May; 34(5):870-5. PMID: 24549187.
    Citations: 6     Fields:    Translation:Animals
  43. Mannix R, Meehan WP, Mandeville J, Grant PE, Gray T, Berglass J, Zhang J, Bryant J, Rezaie S, Chung JY, Peters NV, Lee C, Tien LW, Kaplan DL, Feany M, Whalen M. Clinical correlates in an experimental model of repetitive mild brain injury. Ann Neurol. 2013 Jul; 74(1):65-75. PMID: 23922306.
    Citations: 40     Fields:    Translation:AnimalsCells
  44. Mannix RC, Zhang J, Berglass J, Qui J, Whalen MJ. Beneficial effect of amyloid beta after controlled cortical impact. Brain Inj. 2013 Jun; 27(6):743-8. PMID: 23672448.
    Citations: 2     Fields:    Translation:Animals
  45. Lin J, Whalen M, Holder D, Hruby G, Decastro GJ, McKiernan J. Neoadjuvant chemotherapy in the treatment of muscle invasive bladder cancer with mixed histology. Can J Urol. 2013 Apr; 20(2):6690-5. PMID: 23587508.
    Citations:    Fields:    Translation:Humans
  46. Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice. J Neurotrauma. 2013 Mar 01; 30(5):382-91. PMID: 23153355.
    Citations: 5     Fields:    Translation:Animals
  47. Sheridan RL, Schaefer PW, Whalen M, Fagan S, Stoddard FJ, Schneider JC, McConkey B, Cancio LC. Case records of the Massachusetts General Hospital. Case 36-2012. Recovery of a 16-year-old girl from trauma and burns after a car accident. N Engl J Med. 2012 Nov 22; 367(21):2027-37. PMID: 23171100.
    Citations:    Fields:    Translation:Humans
  48. Meehan WP, Zhang J, Mannix R, Whalen MJ. Increasing recovery time between injuries improves cognitive outcome after repetitive mild concussive brain injuries in mice. Neurosurgery. 2012 Oct; 71(4):885-91. PMID: 22743360.
    Citations: 31     Fields:    Translation:AnimalsCells
  49. Yager PH, Cummings BM, Whalen MJ, Noviski N. Nighttime telecommunication between remote staff intensivists and bedside personnel in a pediatric intensive care unit: a retrospective study. Crit Care Med. 2012 Sep; 40(9):2700-3. PMID: 22732287.
    Citations: 2     Fields:    Translation:Humans
  50. Walker KR, Kang EL, Whalen MJ, Shen Y, Tesco G. Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1. J Neurosci. 2012 Jul 25; 32(30):10423-37. PMID: 22836275.
    Citations: 23     Fields:    Translation:AnimalsCells
  51. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519.
    Citations: 11     Fields:    Translation:Animals
  52. Kates M, Whalen MJ, Badalato GM, McKiernan JM. The effect of race and gender on the surgical management of the small renal mass. Urol Oncol. 2013 Nov; 31(8):1794-9. PMID: 22687567.
    Citations: 6     Fields:    Translation:Humans
  53. Mannix RC, Whalen MJ. Traumatic brain injury, microglia, and Beta amyloid. Int J Alzheimers Dis. 2012; 2012:608732. PMID: 22666622.
    Citations: 16     
  54. Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, Whalen MJ, Lo EH. Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury. Transl Stroke Res. 2012 Jul; 3 Suppl 1:S119-24. PMID: 22773936.
    Citations: 17     Fields:    
  55. Foerch C, You Z, Wang H, Lo EH, Whalen MJ. Traumatic brain injury during warfarin anticoagulation: an experimental study in mice. J Neurotrauma. 2012 Apr 10; 29(6):1150-5. PMID: 22142342.
    Citations: 3     Fields:    Translation:Animals
  56. Wu Q, Xuan W, Ando T, Xu T, Huang L, Huang YY, Dai T, Dhital S, Sharma SK, Whalen MJ, Hamblin MR. Low-level laser therapy for closed-head traumatic brain injury in mice: effect of different wavelengths. Lasers Surg Med. 2012 Mar; 44(3):218-26. PMID: 22275301.
    Citations: 22     Fields:    Translation:Animals
  57. Seo JH, Guo S, Lok J, Navaratna D, Whalen MJ, Kim KW, Lo EH. Neurovascular matrix metalloproteinases and the blood-brain barrier. Curr Pharm Des. 2012; 18(25):3645-8. PMID: 22574977.
    Citations: 22     Fields:    Translation:Humans
  58. Mbye LH, Keles E, Tao L, Zhang J, Chung J, Larvie M, Koppula R, Lo EH, Whalen MJ. Kollidon VA64, a membrane-resealing agent, reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2012 Mar; 32(3):515-24. PMID: 22086196.
    Citations: 13     Fields:    Translation:AnimalsCells
  59. Zhu X, Tao L, Tejima-Mandeville E, Qiu J, Park J, Garber K, Ericsson M, Lo EH, Whalen MJ. Plasmalemma permeability and necrotic cell death phenotypes after intracerebral hemorrhage in mice. Stroke. 2012 Feb; 43(2):524-31. PMID: 22076006.
    Citations: 21     Fields:    Translation:AnimalsCells
  60. Ando T, Xuan W, Xu T, Dai T, Sharma SK, Kharkwal GB, Huang YY, Wu Q, Whalen MJ, Sato S, Obara M, Hamblin MR. Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice. PLoS One. 2011; 6(10):e26212. PMID: 22028832.
    Citations: 24     Fields:    Translation:Animals
  61. Park J, Zhang J, Qiu J, Zhu X, Degterev A, Lo EH, Whalen MJ. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):330-40. PMID: 21934697.
    Citations: 26     Fields:    Translation:AnimalsCells
  62. Khuman J, Zhang J, Park J, Carroll JD, Donahue C, Whalen MJ. Low-level laser light therapy improves cognitive deficits and inhibits microglial activation after controlled cortical impact in mice. J Neurotrauma. 2012 Jan 20; 29(2):408-17. PMID: 21851183.
    Citations: 26     Fields:    Translation:AnimalsCells
  63. Krajewska M, You Z, Rong J, Kress C, Huang X, Yang J, Kyoda T, Leyva R, Banares S, Hu Y, Sze CH, Whalen MJ, Salmena L, Hakem R, Head BP, Reed JC, Krajewski S. Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. PLoS One. 2011; 6(9):e24341. PMID: 21957448.
    Citations: 20     Fields:    Translation:AnimalsCells
  64. Mannix RC, Zhang J, Park J, Lee C, Whalen MJ. Detrimental effect of genetic inhibition of B-site APP-cleaving enzyme 1 on functional outcome after controlled cortical impact in young adult mice. J Neurotrauma. 2011 Sep; 28(9):1855-61. PMID: 21639727.
    Citations: 11     Fields:    Translation:Animals
  65. Badr CE, Wurdinger T, Nilsson J, Niers JM, Whalen M, Degterev A, Tannous BA. Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway. Neuro Oncol. 2011 Nov; 13(11):1213-24. PMID: 21757445.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  66. Khuman J, Meehan WP, Zhu X, Qiu J, Hoffmann U, Zhang J, Giovannone E, Lo EH, Whalen MJ. Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. J Cereb Blood Flow Metab. 2011 Feb; 31(2):778-89. PMID: 20940727.
    Citations: 28     Fields:    Translation:AnimalsCells
  67. Mannix RC, Zhang J, Park J, Zhang X, Bilal K, Walker K, Tanzi RE, Tesco G, Whalen MJ. Age-dependent effect of apolipoprotein E4 on functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2011 Jan; 31(1):351-61. PMID: 20588316.
    Citations: 18     Fields:    Translation:AnimalsCells
  68. Yang J, You Z, Kim HH, Hwang SK, Khuman J, Guo S, Lo EH, Whalen MJ. Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice. J Neurotrauma. 2010 Jun; 27(6):1037-46. PMID: 20205514.
    Citations: 22     Fields:    Translation:Animals
  69. Morelli L, Contu D, Santoni F, Whalen MB, Francalacci P, Cucca F. A comparison of Y-chromosome variation in Sardinia and Anatolia is more consistent with cultural rather than demic diffusion of agriculture. PLoS One. 2010 Apr 29; 5(4):e10419. PMID: 20454687.
    Citations: 10     Fields:    Translation:HumansCells
  70. Arif H, Buchsbaum R, Pierro J, Whalen M, Sims J, Resor SR, Bazil CW, Hirsch LJ. Comparative effectiveness of 10 antiepileptic drugs in older adults with epilepsy. Arch Neurol. 2010 Apr; 67(4):408-15. PMID: 20385905.
    Citations: 12     Fields:    Translation:Humans
  71. Liu CH, You Z, Liu CM, Kim YR, Whalen MJ, Rosen BR, Liu PK. Diffusion-weighted magnetic resonance imaging reversal by gene knockdown of matrix metalloproteinase-9 activities in live animal brains. J Neurosci. 2009 Mar 18; 29(11):3508-17. PMID: 19295156.
    Citations: 11     Fields:    Translation:Animals
  72. You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1564-73. PMID: 18493258.
    Citations: 102     Fields:    Translation:Animals
  73. Yager PH, You Z, Qin T, Kim HH, Takahashi K, Ezekowitz AB, Stahl GL, Carroll MC, Whalen MJ. Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice. J Cereb Blood Flow Metab. 2008 May; 28(5):1030-9. PMID: 18183030.
    Citations: 16     Fields:    Translation:Animals
  74. Lok J, Wang H, Murata Y, Zhu HH, Qin T, Whalen MJ, Lo EH. Effect of neuregulin-1 on histopathological and functional outcome after controlled cortical impact in mice. J Neurotrauma. 2007 Dec; 24(12):1817-22. PMID: 18159993.
    Citations: 6     Fields:    Translation:Animals
  75. Whalen MJ, Dalkara T, You Z, Qiu J, Bermpohl D, Mehta N, Suter B, Bhide PG, Lo EH, Ericsson M, Moskowitz MA. Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Mar; 28(3):490-505. PMID: 17713463.
    Citations: 39     Fields:    Translation:AnimalsCells
  76. You Z, Yang J, Takahashi K, Yager PH, Kim HH, Qin T, Stahl GL, Ezekowitz RA, Carroll MC, Whalen MJ. Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4. J Cereb Blood Flow Metab. 2007 Dec; 27(12):1954-64. PMID: 17457366.
    Citations: 19     Fields:    Translation:HumansAnimals
  77. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH. Cell-cell signaling in the neurovascular unit. Neurochem Res. 2007 Dec; 32(12):2032-45. PMID: 17457674.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  78. Bermpohl D, You Z, Lo EH, Kim HH, Whalen MJ. TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1806-18. PMID: 17406655.
    Citations: 36     Fields:    Translation:AnimalsCells
  79. Bermpohl D, You Z, Korsmeyer SJ, Moskowitz MA, Whalen MJ. Traumatic brain injury in mice deficient in Bid: effects on histopathology and functional outcome. J Cereb Blood Flow Metab. 2006 May; 26(5):625-33. PMID: 16395279.
    Citations: 35     Fields:    Translation:Animals
  80. Hainsworth AH, Bermpohl D, Webb TE, Darwish R, Fiskum G, Qiu J, McCarthy D, Moskowitz MA, Whalen MJ. Expression of cellular FLICE inhibitory proteins (cFLIP) in normal and traumatic murine and human cerebral cortex. J Cereb Blood Flow Metab. 2005 Aug; 25(8):1030-40. PMID: 15815586.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  81. Sheibani N, Grabowski EF, Schoenfeld DA, Whalen MJ. Effect of granulocyte colony-stimulating factor on functional and histopathologic outcome after traumatic brain injury in mice. Crit Care Med. 2004 Nov; 32(11):2274-8. PMID: 15640641.
    Citations: 4     Fields:    Translation:AnimalsCells
  82. Yoshimura S, Teramoto T, Whalen MJ, Irizarry MC, Takagi Y, Qiu J, Harada J, Waeber C, Breakefield XO, Moskowitz MA. FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice. J Clin Invest. 2003 Oct; 112(8):1202-10. PMID: 14561705.
    Citations: 40     Fields:    Translation:AnimalsCells
  83. Prodhan P, Noviski NN, Butler WE, Eskandar E, Ellen Grant P, Whalen MJ. Orbital compartment syndrome mimicking cerebral herniation in a 12-yr-old boy with severe traumatic asphyxia. Pediatr Crit Care Med. 2003 Jul; 4(3):367-9. PMID: 12831422.
    Citations:    Fields:    Translation:Humans
  84. Whalen MJ. Predicting outcome in childhood bacterial meningitis: are pneumococci stronger than glutamate? Pediatr Crit Care Med. 2003 Apr; 4(2):260-1. PMID: 12749667.
    Citations:    Fields:    Translation:Humans
  85. Whalen MJ. Predicting significant vasospasm in patients with subarachnoid hemorrhage: a role for bedside microdialysis? Crit Care Med. 2002 May; 30(5):1171-3. PMID: 12006828.
    Citations:    Fields:    Translation:Humans
  86. Qiu J, Whalen MJ, Lowenstein P, Fiskum G, Fahy B, Darwish R, Aarabi B, Yuan J, Moskowitz MA. Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J Neurosci. 2002 May 01; 22(9):3504-11. PMID: 11978827.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  87. Bates B, Hirt L, Thomas SS, Akbarian S, Le D, Amin-Hanjani S, Whalen M, Jaenisch R, Moskowitz MA. Neurotrophin-3 promotes cell death induced in cerebral ischemia, oxygen-glucose deprivation, and oxidative stress: possible involvement of oxygen free radicals. Neurobiol Dis. 2002 Feb; 9(1):24-37. PMID: 11848682.
    Citations: 7     Fields:    Translation:AnimalsCells
  88. Whalen MJ, Carlos TM, Wisniewski SR, Clark RS, Mellick JA, Marion DW, Kochanek PM. Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats. Crit Care Med. 2000 Nov; 28(11):3710-7. PMID: 11098978.
    Citations: 11     Fields:    Translation:AnimalsCells
  89. Clark RS, Kochanek PM, Adelson PD, Bell MJ, Carcillo JA, Chen M, Wisniewski SR, Janesko K, Whalen MJ, Graham SH. Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury. J Pediatr. 2000 Aug; 137(2):197-204. PMID: 10931412.
    Citations: 22     Fields:    Translation:HumansCells
  90. Kochanek PM, Clark RS, Ruppel RA, Adelson PD, Bell MJ, Whalen MJ, Robertson CL, Satchell MA, Seidberg NA, Marion DW, Jenkins LW. Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: Lessons learned from the bedside. Pediatr Crit Care Med. 2000 Jul; 1(1):4-19. PMID: 12813280.
    Citations: 41     Fields:    
  91. Whalen MJ, Doughty LA, Carlos TM, Wisniewski SR, Kochanek PM, Carcillo JA. Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 are increased in the plasma of children with sepsis-induced multiple organ failure. Crit Care Med. 2000 Jul; 28(7):2600-7. PMID: 10921602.
    Citations: 17     Fields:    Translation:Humans
  92. Whalen MJ, Carlos TM, Kochanek PM, Wisniewski SR, Bell MJ, Clark RS, DeKosky ST, Marion DW, Adelson PD. Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury. Crit Care Med. 2000 Apr; 28(4):929-34. PMID: 10809261.
    Citations: 41     Fields:    Translation:Humans
  93. Whalen MJ, Carlos TM, Dixon CE, Robichaud P, Clark RS, Marion DW, Kochanek PM. Reduced brain edema after traumatic brain injury in mice deficient in P-selectin and intercellular adhesion molecule-1. J Leukoc Biol. 2000 Feb; 67(2):160-8. PMID: 10670575.
    Citations: 16     Fields:    Translation:Animals
  94. Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham S, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase: a preliminary report. Acta Neurochir Suppl. 2000; 76:61-4. PMID: 11450092.
    Citations: 6     Fields:    Translation:Animals
  95. Whalen MJ, Clark RS, Dixon CE, Robichaud P, Marion DW, Vagni V, Graham SH, Virag L, Hasko G, Stachlewitz R, Szabo C, Kochanek PM. Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase. J Cereb Blood Flow Metab. 1999 Aug; 19(8):835-42. PMID: 10458590.
    Citations: 30     Fields:    Translation:Animals
  96. Whalen MJ, Carlos TM, Kochanek PM, Clark RS, Heineman S, Schiding JK, Franicola D, Memarzadeh F, Lo W, Marion DW, Dekosky ST. Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats. J Neurotrauma. 1999 Jul; 16(7):583-94. PMID: 10447070.
    Citations: 13     Fields:    Translation:AnimalsCells
  97. Whalen MJ, Carlos TM, Clark RS, Kochanek PM. An acute inflammatory response to the use of granulocyte colony-stimulating factor to prevent infections in patients with brain injury: what about the brain? Crit Care Med. 1999 May; 27(5):1014-8. PMID: 10362429.
    Citations: 2     Fields:    Translation:HumansCells
  98. Maffei FA, Heine RP, Whalen MJ, Mortimer LF, Carcillo JA. Levels of antimicrobial molecules defensin and lactoferrin are elevated in the cerebrospinal fluid of children with meningitis. Pediatrics. 1999 May; 103(5 Pt 1):987-92. PMID: 10224177.
    Citations: 3     Fields:    Translation:HumansCells
  99. Whalen MJ, Carlos TM, Dixon CE, Schiding JK, Clark RS, Baum E, Yan HQ, Marion DW, Kochanek PM. Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome. J Neurotrauma. 1999 Apr; 16(4):299-309. PMID: 10225216.
    Citations: 23     Fields:    Translation:AnimalsCells
  100. Kochanek PM, Venkataraman S, Whalen MJ, Dalton H. Is the administration of inhaled nitric oxide (NO) associated with electroencephalogram abnormalities? There is NO harm in looking. Crit Care Med. 1998 Nov; 26(11):1788-9. PMID: 9824066.
    Citations:    Fields:    Translation:HumansAnimals
  101. Whalen MJ, Carlos TM, Kochanek PM, Wisniewski SR, Bell MJ, Carcillo JA, Clark RS, DeKosky ST, Adelson PD. Soluble adhesion molecules in CSF are increased in children with severe head injury. J Neurotrauma. 1998 Oct; 15(10):777-87. PMID: 9814634.
    Citations: 11     Fields:    Translation:Humans
  102. Carcillo JA, Korzekwa KR, Jones GS, Parise RA, Gillespie DG, Whalen MJ, Kochanek PM, Branch RA, Kost CK. The cytochrome P450 suicide inhibitor, 1-aminobenzotriazole, sensitizes rats to zymosan-induced toxicity. Res Commun Mol Pathol Pharmacol. 1998 Oct; 102(1):57-68. PMID: 9920346.
    Citations: 3     Fields:    Translation:AnimalsCells
  103. Adelson PD, Whalen MJ, Kochanek PM, Robichaud P, Carlos TM. Blood brain barrier permeability and acute inflammation in two models of traumatic brain injury in the immature rat: a preliminary report. Acta Neurochir Suppl. 1998; 71:104-6. PMID: 9779157.
    Citations: 32     Fields:    Translation:Animals
  104. Whalen MJ, Carlos TM, Kochanek PM, Heineman S. Blood-brain barrier permeability, neutrophil accumulation and vascular adhesion molecule expression after controlled cortical impact in rats: a preliminary study. Acta Neurochir Suppl. 1998; 71:212-4. PMID: 9779187.
    Citations: 10     Fields:    Translation:AnimalsCells
  105. Whalen MJ, Carlos TM, Clark RS, Marion DW, DeKosky ST, Heineman S, Schiding JK, Memarzadeh F, Kochanek PM. The effect of brain temperature on acute inflammation after traumatic brain injury in rats. J Neurotrauma. 1997 Aug; 14(8):561-72. PMID: 9300566.
    Citations: 14     Fields:    Translation:AnimalsCells
  106. Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS, Wisniewski SR, Whalen MJ, DeKosky ST. Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children. J Neurotrauma. 1997 Jul; 14(7):451-7. PMID: 9257663.
    Citations: 56     Fields:    Translation:Humans
  107. Bell MJ, Kochanek PM, Doughty LA, Carcillo JA, Adelson PD, Clark RS, Whalen MJ, DeKosky ST. Comparison of the interleukin-6 and interleukin-10 response in children after severe traumatic brain injury or septic shock. Acta Neurochir Suppl. 1997; 70:96-7. PMID: 9416290.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  108. Whalen MJ, Carlos TM, Clark RS, Marion DW, DeKosky MS, Heineman S, Schiding JK, Memarzadeh F, Dixon CE, Kochanek PM. The relationship between brain temperature and neutrophil accumulation after traumatic brain injury in rats. Acta Neurochir Suppl. 1997; 70:260-1. PMID: 9416340.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.