Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Alexander Peter Lin, Ph.D.

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Other Positions
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Biography
2014
Young Mentor Award
2011
Clinical Research Excellence Award
2011
Partners in Excellence Team Award

Overview
Dr. Lin is the director of the Center for Clinical Spectroscopy at Brigham and Women’s Hospital and Assistant Professor of Radiology at Harvard Medical School. Dr. Lin is a graduate of the California Institute of Technology, where he completed his Masters degree in Bioengineering and his doctoral degree in Biochemistry and Molecular Biophysics. He began his training as a research associate in 1997 and was appointed Director of Clinical Services and Senior Scientist at the Magnetic Resonance Spectroscopy Unit at the Huntington Medical Research Institutes in 2003. Since that time, he has been a visiting research associate at the Center of MR Research at the University of Illinois Chicago. From 2007 to 2009, Dr. Lin had a research fellowship at the National Heart, Lung and Blood Institute at the National Institutes of Health in Bethesda, MD. Dr. Lin arrived at Brigham and Women’s Hospital in 2009.

Dr. Lin’s research interests include clinical applications of multinuclear magnetic resonance spectroscopy in the brain, breast, and liver, and cardiovascular magnetic resonance imaging. He was awarded the Young Investigator’s Award in 2003 for his work in 13C spectroscopy in Alzheimer’s disease and an NHLBI Fellows Research Award for his work in strain mapping of the carotid arteries in 2007. He was recently awarded a Congressionally Directed Medical Research Program grant from the Department of Defense to study mild traumatic brain injury and post-traumatic stress disorder in soldiers returning from the Iraq/Afghanistan wars. In addition, he has ongoing collaborations with the Boston University Center for Study of Traumatic Encephalopathy to examine the long-term effects of repetitive head injury using magnetic resonance spectroscopy. He has co-authored more than three dozen peer-reviewed publications, five book chapters, and 75+ conference abstracts.

Finally, Dr. Alexander Lin has also been recognized through awards and media reports for his efforts in supporting mentorship, particularly of students of diversity through the laboratory’s involvement in the Student Success Jobs Program and Harvard Catalyst summer research studies. He actively mentors Harvard Medical School students and received a Young Mentor Award from Harvard Medical School. Further, he is involved in education and training in several international workshops for MR spectroscopy.

Mentoring
Available: 01/01/20, Expires: 01/01/22

The Center for Clinical Spectroscopy develops cutting edge diagnostic tools using magnetic resonance imaging and spectroscopy. There are several ongoing projects involving magnetic resonance imaging and spectroscopy of the brain, including research on the effect of traumatic brain injury on football players and soldiers, some of which was recently featured in the media. Other projects include studies in brain cancer, schizophrenia, muscle metabolism, sleep, etc.

Your role will be dependent on your interests and experience. Excellent opportunities to publish papers.

Player Position, Impact Severity, and Brain Chemistry in Retired National Football League Athletes
Summer, 06/09/14 - 08/15/14
Magnetic Resonance Spectroscopy in mTBI and PTS
Summer, 06/08/15 - 08/14/15

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Koerte IK, Bahr R, Filipcik P, Gooijers J, Leemans A, Lin AP, Tripodis Y, Shenton ME, Sochen N, Swinnen SP, Pasternak O. REPIMPACT - a prospective longitudinal multisite study on the effects of repetitive head impacts in youth soccer. Brain Imaging Behav. 2021 Sep 10. PMID: 34505977.
    Citations:    Fields:    
  2. Alosco ML, Mariani ML, Adler CH, Balcer LJ, Bernick C, Au R, Banks SJ, Barr WB, Bouix S, Cantu RC, Coleman MJ, Dodick DW, Farrer LA, Geda YE, Katz DI, Koerte IK, Kowall NW, Lin AP, Marcus DS, Marek KL, McClean MD, McKee AC, Mez J, Palmisano JN, Peskind ER, Tripodis Y, Turner RW, Wethe JV, Cummings JL, Reiman EM, Shenton ME, Stern RA. Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project. Alzheimers Res Ther. 2021 08 12; 13(1):136. PMID: 34384490.
    Citations:    Fields:    Translation:HumansPHPublic Health
  3. Kochsiek J, O'Donnell LJ, Zhang F, Bonke EM, Sollmann N, Tripodis Y, Wiegand TLT, Kaufmann D, Umminger L, Di Biase MA, Kaufmann E, Schultz V, Alosco ML, Martin BM, Lin AP, Coleman MJ, Rathi Y, Pasternak O, Bouix S, Stern RA, Shenton ME, Koerte IK. Exposure to Repetitive Head Impacts Is Associated With Corpus Callosum Microstructure and Plasma Total Tau in Former Professional American Football Players. J Magn Reson Imaging. 2021 Jun 16. PMID: 34137112.
    Citations: 1     Fields:    
  4. Kaufmann D, Sollmann N, Kaufmann E, Veggeberg R, Tripodis Y, Wrobel PP, Kochsiek J, Martin BM, Lin AP, Coleman MJ, Alosco ML, Pasternak O, Bouix S, Stern RA, Shenton ME, Koerte IK. Age at First Exposure to Tackle Football is Associated with Cortical Thickness in Former Professional American Football Players. Cereb Cortex. 2021 06 10; 31(7):3426-3434. PMID: 33676369.
    Citations: 1     Fields:    
  5. Koerte IK, Esopenko C, Hinds SR, Shenton ME, Bonke EM, Bazarian JJ, Bickart KC, Bigler ED, Bouix S, Buckley TA, Choe MC, Echlin PS, Gill J, Giza CC, Hayes J, Hodges CB, Irimia A, Johnson PK, Kenney K, Levin HS, Lin AP, Lindsey HM, Lipton ML, Max JE, Mayer AR, Meier TB, Merchant-Borna K, Merkley TL, Mills BD, Newsome MR, Porfido T, Stephens JA, Tartaglia MC, Ware AL, Zafonte RD, Zeineh MM, Thompson PM, Tate DF, Dennis EL, Wilde EA, Baron D. The ENIGMA sports injury working group:- an international collaboration to further our understanding of sport-related brain injury. Brain Imaging Behav. 2021 Apr; 15(2):576-584. PMID: 32720179.
    Citations: 2     Fields:    Translation:Humans
  6. Wiegand TLT, Sollmann N, Bonke EM, Umeasalugo KE, Sobolewski KR, Plesnila N, Shenton ME, Lin AP, Koerte IK. Translational neuroimaging in mild traumatic brain injury. J Neurosci Res. 2021 Mar 31. PMID: 33789358.
    Citations:    Fields:    
  7. Wiggins CJ, Choi C, Li Y, Lin AP, Thakur SB, Ratai EM. Shimming-the forgotten child of in-vivo MR? MAGMA. 2021 04; 34(2):179-181. PMID: 33768364.
    Citations:    Fields:    Translation:Humans
  8. Stergachis AB, Krier JB, Merugumala SK, Berry GT, Lin AP. Clinical utility of brain MRS imaging of patients with adult-onset non-cirrhotic hyperammonemia. Mol Genet Metab Rep. 2021 Jun; 27:100742. PMID: 33763331.
    Citations:    
  9. Afacan O, Yang E, Lin AP, Coello E, DiBacco ML, Pearl PL, Warfield SK, Consortium SDI. Magnetic Resonance Imaging (MRI) and Spectroscopy in Succinic Semialdehyde Dehydrogenase Deficiency. J Child Neurol. 2021 Feb 09; 883073821991295. PMID: 33557675.
    Citations:    Fields:    
  10. Zhou M, Dong C, Li C, Wang Y, Liao H, Shi H, Lin AP, Wang J, Hu Y, Zheng C. Longitudinal changes in COVID-19 clinical measures and correlation with the extent of CT lung abnormalities. Int J Med Sci. 2021; 18(5):1277-1284. PMID: 33526989.
    Citations: 1     Fields:    Translation:Humans
  11. Esopenko C, Meyer J, Wilde EA, Marshall AD, Tate DF, Lin AP, Koerte IK, Werner KB, Dennis EL, Ware AL, de Souza NL, Menefee DS, Dams-O'Connor K, Stein DJ, Bigler ED, Shenton ME, Chiou KS, Postmus JL, Monahan K, Eagan-Johnson B, van Donkelaar P, Merkley TL, Velez C, Hodges CB, Lindsey HM, Johnson P, Irimia A, Spruiell M, Bennett ER, Bridwell A, Zieman G, Hillary FG. A global collaboration to study intimate partner violence-related head trauma: The ENIGMA consortium IPV working group. Brain Imaging Behav. 2021 Apr; 15(2):475-503. PMID: 33405096.
    Citations: 1     Fields:    Translation:Humans
  12. Charney MF, Howell DR, Lanois C, Starr TC, Liao H, Coello E, Breedlove KM, Meehan WP, Koerte I, Lin AP. Associations Between Neurochemistry and Gait Performance Following Concussion in Collegiate Athletes. J Head Trauma Rehabil. 2020 Sep/Oct; 35(5):342-353. PMID: 32881768.
    Citations: 1     Fields:    Translation:Humans
  13. Stergachis AB, Mogensen KM, Khoury CC, Lin AP, Peake RW, Baker JJ, Barkoudah E, Sahai I, Sweetser DA, Berry GT, Krier JB. A retrospective study of adult patients with noncirrhotic hyperammonemia. J Inherit Metab Dis. 2020 11; 43(6):1165-1172. PMID: 32713002.
    Citations: 1     Fields:    Translation:Humans
  14. Koerte IK, Schultz V, Sydnor VJ, Howell DR, Guenette JP, Dennis E, Kochsiek J, Kaufmann D, Sollmann N, Mondello S, Shenton ME, Lin AP. Sex-Related Differences in the Effects of Sports-Related Concussion: A Review. J Neuroimaging. 2020 07; 30(4):387-409. PMID: 32533752.
    Citations: 5     Fields:    Translation:Humans
  15. Dennis EL, Baron D, Bartnik-Olson B, Caeyenberghs K, Esopenko C, Hillary FG, Kenney K, Koerte IK, Lin AP, Mayer AR, Mondello S, Olsen A, Thompson PM, Tate DF, Wilde EA. ENIGMA brain injury: Framework, challenges, and opportunities. Hum Brain Mapp. 2020 Jun 01. PMID: 32476212.
    Citations: 4     Fields:    
  16. Howell DR, Oldham J, Lanois C, Koerte I, Lin AP, Berkstresser B, Wang F, Meehan WP. Dual-Task Gait Recovery after Concussion among Female and Male Collegiate Athletes. Med Sci Sports Exerc. 2020 05; 52(5):1015-1021. PMID: 31985574.
    Citations: 1     Fields:    Translation:Humans
  17. Thompson PM, Jahanshad N, Ching CRK, Salminen LE, Thomopoulos SI, Bright J, Baune BT, Bertolín S, Bralten J, Bruin WB, Bülow R, Chen J, Chye Y, Dannlowski U, de Kovel CGF, Donohoe G, Eyler LT, Faraone SV, Favre P, Filippi CA, Frodl T, Garijo D, Gil Y, Grabe HJ, Grasby KL, Hajek T, Han LKM, Hatton SN, Hilbert K, Ho TC, Holleran L, Homuth G, Hosten N, Houenou J, Ivanov I, Jia T, Kelly S, Klein M, Kwon JS, Laansma MA, Leerssen J, Lueken U, Nunes A, Neill JO, Opel N, Piras F, Piras F, Postema MC, Pozzi E, Shatokhina N, Soriano-Mas C, Spalletta G, Sun D, Teumer A, Tilot AK, Tozzi L, van der Merwe C, Van Someren EJW, van Wingen GA, Völzke H, Walton E, Wang L, Winkler AM, Wittfeld K, Wright MJ, Yun JY, Zhang G, Zhang-James Y, Adhikari BM, Agartz I, Aghajani M, Aleman A, Althoff RR, Altmann A, Andreassen OA, Baron DA, Bartnik-Olson BL, Marie Bas-Hoogendam J, Baskin-Sommers AR, Bearden CE, Berner LA, Boedhoe PSW, Brouwer RM, Buitelaar JK, Caeyenberghs K, Cecil CAM, Cohen RA, Cole JH, Conrod PJ, De Brito SA, de Zwarte SMC, Dennis EL, Desrivieres S, Dima D, Ehrlich S, Esopenko C, Fairchild G, Fisher SE, Fouche JP, Francks C, Frangou S, Franke B, Garavan HP, Glahn DC, Groenewold NA, Gurholt TP, Gutman BA, Hahn T, Harding IH, Hernaus D, Hibar DP, Hillary FG, Hoogman M, Hulshoff Pol HE, Jalbrzikowski M, Karkashadze GA, Klapwijk ET, Knickmeyer RC, Kochunov P, Koerte IK, Kong XZ, Liew SL, Lin AP, Logue MW, Luders E, Macciardi F, Mackey S, Mayer AR, McDonald CR, McMahon AB, Medland SE, Modinos G, Morey RA, Mueller SC, Mukherjee P, Namazova-Baranova L, Nir TM, Olsen A, Paschou P, Pine DS, Pizzagalli F, Rentería ME, Rohrer JD, Sämann PG, Schmaal L, Schumann G, Shiroishi MS, Sisodiya SM, Smit DJA, Sønderby IE, Stein DJ, Stein JL, Tahmasian M, Tate DF, Turner JA, van den Heuvel OA, van der Wee NJA, van der Werf YD, van Erp TGM, van Haren NEM, van Rooij D, van Velzen LS, Veer IM, Veltman DJ, Villalon-Reina JE, Walter H, Whelan CD, Wilde EA, Zarei M, Zelman V. ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries. Transl Psychiatry. 2020 03 20; 10(1):100. PMID: 32198361.
    Citations: 45     Fields:    Translation:Humans
  18. Alosco ML, Tripodis Y, Koerte IK, Jackson JD, Chua AS, Mariani M, Haller O, Foley ÉM, Martin BM, Palmisano J, Singh B, Green K, Lepage C, Muehlmann M, Makris N, Cantu RC, Lin AP, Coleman M, Pasternak O, Mez J, Bouix S, Shenton ME, Stern RA. Interactive Effects of Racial Identity and Repetitive Head Impacts on Cognitive Function, Structural MRI-Derived Volumetric Measures, and Cerebrospinal Fluid Tau and Aß. Front Hum Neurosci. 2019; 13:440. PMID: 31920598.
    Citations: 5     
  19. Lepage C, Muehlmann M, Tripodis Y, Hufschmidt J, Stamm J, Green K, Wrobel P, Schultz V, Weir I, Alosco ML, Baugh CM, Fritts NG, Martin BM, Chaisson C, Coleman MJ, Lin AP, Pasternak O, Makris N, Stern RA, Shenton ME, Koerte IK. Limbic system structure volumes and associated neurocognitive functioning in former NFL players. Brain Imaging Behav. 2019 Jun; 13(3):725-734. PMID: 29779184.
    Citations: 11     Fields:    Translation:Humans
  20. Wilson M, Andronesi O, Barker PB, Bartha R, Bizzi A, Bolan PJ, Brindle KM, Choi IY, Cudalbu C, Dydak U, Emir UE, Gonzalez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Huppi PS, Hurd RE, Kantarci K, Kauppinen RA, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Mullins PG, Murdoch JB, Nelson SJ, Noeske R, Öz G, Pan JW, Peet AC, Poptani H, Posse S, Ratai EM, Salibi N, Scheenen TWJ, Smith ICP, Soher BJ, Tkác I, Vigneron DB, Howe FA. Methodological consensus on clinical proton MRS of the brain: Review and recommendations. Magn Reson Med. 2019 08; 82(2):527-550. PMID: 30919510.
    Citations: 51     Fields:    Translation:Humans
  21. Lin AP. Overcoming Technical Challenges of MR Spectroscopy in Chronic Spinal Cord Injury. Radiology. 2019 Apr; 291(1):139-140. PMID: 30694155.
    Citations:    Fields:    Translation:Humans
  22. Bevers MB, Scirica BM, Avery KR, Henderson GV, Lin AP, Lee JW. Combination of Clinical Exam, MRI and EEG to Predict Outcome Following Cardiac Arrest and Targeted Temperature Management. Neurocrit Care. 2018 12; 29(3):396-403. PMID: 29949008.
    Citations: 3     Fields:    Translation:Humans
  23. Panchal H, Sollmann N, Pasternak O, Alosco ML, Kinzel P, Kaufmann D, Hartl E, Forwell LA, Johnson AM, Skopelja EN, Shenton ME, Koerte IK, Echlin PS, Lin AP. Neuro-Metabolite Changes in a Single Season of University Ice Hockey Using Magnetic Resonance Spectroscopy. Front Neurol. 2018; 9:616. PMID: 30177905.
    Citations: 3     
  24. Zhou M, Zhou Y, Liao H, Rowland BC, Kong X, Arvold ND, Reardon DA, Wen PY, Lin AP, Huang RY. Diagnostic accuracy of 2-hydroxyglutarate magnetic resonance spectroscopy in newly diagnosed brain mass and suspected recurrent gliomas. Neuro Oncol. 2018 08 02; 20(9):1262-1271. PMID: 29438510.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  25. Grizales AM, Patti ME, Lin AP, Beckman JA, Sahni VA, Cloutier E, Fowler KM, Dreyfuss JM, Pan H, Kozuka C, Lee A, Basu R, Pober DM, Gerszten RE, Goldfine AB. Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes. J Clin Endocrinol Metab. 2018 08 01; 103(8):3038-3049. PMID: 29860335.
    Citations: 6     Fields:    Translation:Humans
  26. Zhou M, Liao H, Sreepada LP, Ladner JR, Balschi JA, Lin AP. Tai Chi Improves Brain Metabolism and Muscle Energetics in Older Adults. J Neuroimaging. 2018 07; 28(4):359-364. PMID: 29667260.
    Citations: 2     Fields:    Translation:Humans
  27. Guenette JP, Stern RA, Tripodis Y, Chua AS, Schultz V, Sydnor VJ, Somes N, Karmacharya S, Lepage C, Wrobel P, Alosco ML, Martin BM, Chaisson CE, Coleman MJ, Lin AP, Pasternak O, Makris N, Shenton ME, Koerte IK. Automated versus manual segmentation of brain region volumes in former football players. Neuroimage Clin. 2018; 18:888-896. PMID: 29876273.
    Citations: 9     Fields:    Translation:Humans
  28. Miller MW, Lin AP, Wolf EJ, Miller DR. Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD. Harv Rev Psychiatry. 2018 Mar/Apr; 26(2):57-69. PMID: 29016379.
    Citations: 32     Fields:    Translation:Humans
  29. Sollmann N, Echlin PS, Schultz V, Viher PV, Lyall AE, Tripodis Y, Kaufmann D, Hartl E, Kinzel P, Forwell LA, Johnson AM, Skopelja EN, Lepage C, Bouix S, Pasternak O, Lin AP, Shenton ME, Koerte IK. Sex differences in white matter alterations following repetitive subconcussive head impacts in collegiate ice hockey players. Neuroimage Clin. 2018; 17:642-649. PMID: 29204342.
    Citations: 12     Fields:    Translation:Humans
  30. Schultz V, Stern RA, Tripodis Y, Stamm J, Wrobel P, Lepage C, Weir I, Guenette JP, Chua A, Alosco ML, Baugh CM, Fritts NG, Martin BM, Chaisson CE, Coleman MJ, Lin AP, Pasternak O, Shenton ME, Koerte IK. Age at First Exposure to Repetitive Head Impacts Is Associated with Smaller Thalamic Volumes in Former Professional American Football Players. J Neurotrauma. 2018 01 15; 35(2):278-285. PMID: 28990457.
    Citations: 23     Fields:    Translation:Humans
  31. Alosco ML, Koerte IK, Tripodis Y, Mariani M, Chua AS, Jarnagin J, Rahimpour Y, Puzo C, Healy RC, Martin B, Chaisson CE, Cantu RC, Au R, McClean M, McKee AC, Lin AP, Shenton ME, Killiany RJ, Stern RA. White matter signal abnormalities in former National Football League players. Alzheimers Dement (Amst). 2018; 10:56-65. PMID: 29201991.
    Citations: 16     
  32. O'Donnell-Luria AH, Lin AP, Merugumala SK, Rohr F, Waisbren SE, Lynch R, Tchekmedyian V, Goldberg AD, Bellinger A, McFaline-Figueroa JR, Simon T, Gershanik EF, Levy BD, Cohen DE, Samuels MA, Berry GT, Frank NY. Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma. Mol Genet Metab. 2017 05; 121(1):9-15. PMID: 28408159.
    Citations: 3     Fields:    Translation:Humans
  33. Gardner AJ, Iverson GL, Wojtowicz M, Levi CR, Kay-Lambkin F, Schofield PW, Zafonte R, Shultz SR, Lin AP, Stanwell P. MR Spectroscopy Findings in Retired Professional Rugby League Players. Int J Sports Med. 2017 Mar; 38(3):241-252. PMID: 28192828.
    Citations: 10     Fields:    Translation:Humans
  34. Waisbren SE, Prabhu SP, Greenstein P, Petty C, Schomer D, Anastasoaie V, Charette K, Rodriguez D, Merugumala S, Lin AP. Improved Measurement of Brain Phenylalanine and Tyrosine Related to Neuropsychological Functioning in Phenylketonuria. JIMD Rep. 2017; 34:77-86. PMID: 27677920.
    Citations: 2     
  35. Rowland BC, Liao H, Adan F, Mariano L, Irvine J, Lin AP. Correcting for Frequency Drift in Clinical Brain MR Spectroscopy. J Neuroimaging. 2017 01; 27(1):23-28. PMID: 27601075.
    Citations: 7     Fields:    Translation:Humans
  36. Koerte IK, Mayinger M, Muehlmann M, Kaufmann D, Lin AP, Steffinger D, Fisch B, Rauchmann BS, Immler S, Karch S, Heinen FR, Ertl-Wagner B, Reiser M, Stern RA, Zafonte R, Shenton ME. Cortical thinning in former professional soccer players. Brain Imaging Behav. 2016 09; 10(3):792-8. PMID: 26286826.
    Citations: 32     Fields:    Translation:Humans
  37. Koerte IK, Hufschmidt J, Muehlmann M, Tripodis Y, Stamm JM, Pasternak O, Giwerc MY, Coleman MJ, Baugh CM, Fritts NG, Heinen F, Lin A, Stern RA, Shenton ME. Cavum Septi Pellucidi in Symptomatic Former Professional Football Players. J Neurotrauma. 2016 Feb 15; 33(4):346-53. PMID: 26414478.
    Citations: 24     Fields:    Translation:Humans
  38. Rowland B, Merugumala SK, Liao H, Creager MA, Balschi J, Lin AP. Spectral improvement by fourier thresholding of in vivo dynamic spectroscopy data. Magn Reson Med. 2016 09; 76(3):978-85. PMID: 26445244.
    Citations: 2     Fields:    Translation:HumansAnimals
  39. Stamm JM, Koerte IK, Muehlmann M, Pasternak O, Bourlas AP, Baugh CM, Giwerc MY, Zhu A, Coleman MJ, Bouix S, Fritts NG, Martin BM, Chaisson C, McClean MD, Lin AP, Cantu RC, Tripodis Y, Stern RA, Shenton ME. Age at First Exposure to Football Is Associated with Altered Corpus Callosum White Matter Microstructure in Former Professional Football Players. J Neurotrauma. 2015 Nov 15; 32(22):1768-76. PMID: 26200068.
    Citations: 57     Fields:    Translation:Humans
  40. Wilde EA, Bouix S, Tate DF, Lin AP, Newsome MR, Taylor BA, Stone JR, Montier J, Gandy SE, Biekman B, Shenton ME, York G. Advanced neuroimaging applied to veterans and service personnel with traumatic brain injury: state of the art and potential benefits. Brain Imaging Behav. 2015 Sep; 9(3):367-402. PMID: 26350144.
    Citations: 13     Fields:    Translation:Humans
  41. Koerte IK, Lin AP, Muehlmann M, Merugumala S, Liao H, Starr T, Kaufmann D, Mayinger M, Steffinger D, Fisch B, Karch S, Heinen F, Ertl-Wagner B, Reiser M, Stern RA, Zafonte R, Shenton ME. Altered Neurochemistry in Former Professional Soccer Players without a History of Concussion. J Neurotrauma. 2015 Sep 01; 32(17):1287-93. PMID: 25843317.
    Citations: 39     Fields:    Translation:Humans
  42. Koerte IK, Lin AP, Willems A, Muehlmann M, Hufschmidt J, Coleman MJ, Green I, Liao H, Tate DF, Wilde EA, Pasternak O, Bouix S, Rathi Y, Bigler ED, Stern RA, Shenton ME. A review of neuroimaging findings in repetitive brain trauma. Brain Pathol. 2015 May; 25(3):318-49. PMID: 25904047.
    Citations: 40     Fields:    Translation:Humans
  43. Lin AP, Ramadan S, Stern RA, Box HC, Nowinski CJ, Ross BD, Mountford CE. Changes in the neurochemistry of athletes with repetitive brain trauma: preliminary results using localized correlated spectroscopy. Alzheimers Res Ther. 2015; 7(1):13. PMID: 25780390.
    Citations: 24     Fields:    
  44. Mountford C, Quadrelli S, Lin A, Ramadan S. Six fucose-a(1-2) sugars and a-fucose assigned in the human brain using in vivo two-dimensional MRS. NMR Biomed. 2015 Mar; 28(3):291-6. PMID: 25534141.
    Citations: 6     Fields:    Translation:Humans
  45. Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dinçer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjanska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tkác I, Vigneron DB, Kauppinen RA. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014 Mar; 270(3):658-79. PMID: 24568703.
    Citations: 155     Fields:    Translation:Humans
  46. Ng TS, Lin AP, Koerte IK, Pasternak O, Liao H, Merugumala S, Bouix S, Shenton ME. Neuroimaging in repetitive brain trauma. Alzheimers Res Ther. 2014; 6(1):10. PMID: 25031630.
    Citations: 18     Fields:    
  47. Rathi Y, Ning L, Michailovich O, Liao H, Gagoski B, Grant PE, Shenton ME, Stern R, Westin CF, Lin A. Maximum entropy estimation of glutamate and glutamine in MR spectroscopic imaging. Med Image Comput Comput Assist Interv. 2014; 17(Pt 2):749-56. PMID: 25485447.
    Citations:    Fields:    Translation:Humans
  48. Ramadan S, Lin A, Stanwell P. Glutamate and glutamine: a review of in vivo MRS in the human brain. NMR Biomed. 2013 Dec; 26(12):1630-46. PMID: 24123328.
    Citations: 59     Fields:    Translation:HumansAnimals
  49. Lin A, Tran T, Bluml S, Merugumala S, Liao HJ, Ross BD. Guidelines for acquiring and reporting clinical neurospectroscopy. Semin Neurol. 2012 Sep; 32(4):432-53. PMID: 23361487.
    Citations: 12     Fields:    Translation:HumansAnimals
  50. Ramadan S, Baltzer PA, Lin A, Stanwell P, Box H, Kaiser WA, Mountford CE. L-COSY of breast cancer at 3T. Eur J Radiol. 2012 Sep; 81 Suppl 1:S129-31. PMID: 23083559.
    Citations:    Fields:    Translation:Humans
  51. Lin AP, Liao HJ, Merugumala SK, Prabhu SP, Meehan WP, Ross BD. Metabolic imaging of mild traumatic brain injury. Brain Imaging Behav. 2012 Jun; 6(2):208-23. PMID: 22684770.
    Citations: 41     Fields:    Translation:Humans
  52. Baugh CM, Stamm JM, Riley DO, Gavett BE, Shenton ME, Lin A, Nowinski CJ, Cantu RC, McKee AC, Stern RA. Chronic traumatic encephalopathy: neurodegeneration following repetitive concussive and subconcussive brain trauma. Brain Imaging Behav. 2012 Jun; 6(2):244-54. PMID: 22552850.
    Citations: 135     Fields:    Translation:Humans
  53. Shenton ME, Hamoda HM, Schneiderman JS, Bouix S, Pasternak O, Rathi Y, Vu MA, Purohit MP, Helmer K, Koerte I, Lin AP, Westin CF, Kikinis R, Kubicki M, Stern RA, Zafonte R. A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury. Brain Imaging Behav. 2012 Jun; 6(2):137-92. PMID: 22438191.
    Citations: 259     Fields:    Translation:Humans
  54. Gavett BE, Cantu RC, Shenton M, Lin AP, Nowinski CJ, McKee AC, Stern RA. Clinical appraisal of chronic traumatic encephalopathy: current perspectives and future directions. Curr Opin Neurol. 2011 Dec; 24(6):525-31. PMID: 22045219.
    Citations: 38     Fields:    Translation:Humans
  55. Ramadan S, Andronesi OC, Stanwell P, Lin AP, Sorensen AG, Mountford CE. Use of in vivo two-dimensional MR spectroscopy to compare the biochemistry of the human brain to that of glioblastoma. Radiology. 2011 May; 259(2):540-9. PMID: 21357517.
    Citations: 12     Fields:    Translation:Humans
  56. Gruber RP, Lin AY, Richards T. Nasal strips for evaluating and classifying valvular nasal obstruction. Aesthetic Plast Surg. 2011 Apr; 35(2):211-5. PMID: 21082181.
    Citations: 3     Fields:    Translation:Humans
  57. Stanwell P, Siddall P, Keshava N, Cocuzzo D, Ramadan S, Lin A, Herbert D, Craig A, Tran Y, Middleton J, Gautam S, Cousins M, Mountford C. Neuro magnetic resonance spectroscopy using wavelet decomposition and statistical testing identifies biochemical changes in people with spinal cord injury and pain. Neuroimage. 2010 Nov 01; 53(2):544-52. PMID: 20600973.
    Citations: 10     Fields:    Translation:Humans
  58. Mountford CE, Stanwell P, Lin A, Ramadan S, Ross B. Neurospectroscopy: the past, present and future. Chem Rev. 2010 May 12; 110(5):3060-86. PMID: 20387805.
    Citations: 40     Fields:    Translation:HumansAnimals
  59. Perman WH, Bhattacharya P, Leupold J, Lin AP, Harris KC, Norton VA, Hövener JB, Ross BD. Fast volumetric spatial-spectral MR imaging of hyperpolarized 13C-labeled compounds using multiple echo 3D bSSFP. Magn Reson Imaging. 2010 May; 28(4):459-65. PMID: 20171034.
    Citations: 10     Fields:    Translation:Animals
  60. Tran T, Ross B, Lin A. Magnetic resonance spectroscopy in neurological diagnosis. Neurol Clin. 2009 Feb; 27(1):21-60, xiii. PMID: 19055974.
    Citations: 12     Fields:    Translation:Humans
  61. Xu V, Chan H, Lin AP, Sailasuta N, Valencerina S, Tran T, Hovener J, Ross BD. MR spectroscopy in diagnosis and neurological decision-making. Semin Neurol. 2008 Sep; 28(4):407-22. PMID: 18843570.
    Citations: 15     Fields:    Translation:Humans
  62. Lin AP, Bennett E, Wisk LE, Gharib M, Fraser SE, Wen H. Circumferential strain in the wall of the common carotid artery: comparing displacement-encoded and cine MRI in volunteers. Magn Reson Med. 2008 Jul; 60(1):8-13. PMID: 18581403.
    Citations: 10     Fields:    Translation:Humans
  63. Haseler LJ, Lin A, Hoff J, Richardson RS. Oxygen availability and PCr recovery rate in untrained human calf muscle: evidence of metabolic limitation in normoxia. . 2007 Nov; 293(5):R2046-51. PMID: 17715186.
    Citations: 22     Translation:HumansCells
  64. Bhattacharya P, Chekmenev EY, Perman WH, Harris KC, Lin AP, Norton VA, Tan CT, Ross BD, Weitekamp DP. Towards hyperpolarized (13)C-succinate imaging of brain cancer. J Magn Reson. 2007 May; 186(1):150-5. PMID: 17303454.
    Citations: 90     Fields:    Translation:Animals
  65. Lin AP, Tran TT, Ross BD. Impact of evidence-based medicine on magnetic resonance spectroscopy. NMR Biomed. 2006 Jun; 19(4):476-83. PMID: 16763969.
    Citations: 5     Fields:    Translation:Humans
  66. Harris K, Lin A, Bhattacharya P, Tran T, Wong W, Ross B. Regulation of NAA-synthesis in the human brain in vivo: Canavan's disease, Alzheimer's disease and schizophrenia. Adv Exp Med Biol. 2006; 576:263-73; discussion 361-3. PMID: 16802718.
    Citations:    Fields:    Translation:HumansCells
  67. Lin AP. Acquiring Magnetic Resonance Spectroscopy in Clinical Practice, Eds. C. Mountford and G.A. Webb. 2006.
  68. Bhattacharya P, Harris K, Lin AP, Mansson M, Norton VA, Perman WH, Weitekamp DP, Ross BD. Ultra-fast three dimensional imaging of hyperpolarized 13C in vivo. MAGMA. 2005 Nov; 18(5):245-56. PMID: 16320090.
    Citations: 40     Fields:    Translation:Animals
  69. Lin A, Ross BD, Harris K, Wong W. Efficacy of proton magnetic resonance spectroscopy in neurological diagnosis and neurotherapeutic decision making. NeuroRx. 2005 Apr; 2(2):197-214. PMID: 15897945.
    Citations: 62     Fields:    Translation:HumansAnimals
  70. England B, Lee A, Tran T, Faw H, Yang P, Lin A, Colletti P, Roth F, Ross BD. Magnetic resonance criteria for future trials of cardiac resynchronization therapy. J Cardiovasc Magn Reson. 2005; 7(5):827-34. PMID: 16353444.
    Citations:    Fields:    Translation:Humans
  71. Haseler LJ, Lin AP, Richardson RS. Skeletal muscle oxidative metabolism in sedentary humans: 31P-MRS assessment of O2 supply and demand limitations. J Appl Physiol (1985). 2004 Sep; 97(3):1077-81. PMID: 15133010.
    Citations: 31     Fields:    Translation:HumansCellsCTClinical Trials
  72. Ross B, Lin A, Harris K, Bhattacharya P, Schweinsburg B. Clinical experience with 13C MRS in vivo. NMR Biomed. 2003 Oct-Nov; 16(6-7):358-69. PMID: 14679500.
    Citations: 40     Fields:    Translation:HumansCells
  73. Lin AP, Shic F, Enriquez C, Ross BD. Reduced glutamate neurotransmission in patients with Alzheimer's disease -- an in vivo (13)C magnetic resonance spectroscopy study. MAGMA. 2003 Feb; 16(1):29-42. PMID: 12695884.
    Citations: 39     Fields:    Translation:HumansCellsCTClinical Trials
  74. Cecil KM, Lin A, Ross BD, Egelhoff JC. Methylsulfonylmethane observed by in vivo proton magnetic resonance spectroscopy in a 5-year-old child with developmental disorder: effects of dietary supplementation. J Comput Assist Tomogr. 2002 Sep-Oct; 26(5):818-20. PMID: 12439321.
    Citations: 4     Fields:    Translation:Humans
  75. Pandit S, Lin A, Gahbauer H, Libertin CR, Erdogan B. MR spectroscopy in neurocysticercosis. J Comput Assist Tomogr. 2001 Nov-Dec; 25(6):950-2. PMID: 11711809.
    Citations: 4     Fields:    Translation:Humans
  76. Lin A, Nguy CH, Shic F, Ross BD. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicol Lett. 2001 Sep 15; 123(2-3):169-77. PMID: 11641045.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  77. Lin AP, Ross BD. Short-echo time proton MR spectroscopy in the presence of gadolinium. J Comput Assist Tomogr. 2001 Sep-Oct; 25(5):705-12. PMID: 11584229.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  78. Ross BD, Hoang TQ, Blüml S, Dubowitz D, Kopyov OV, Jacques DB, Lin A, Seymour K, Tan J. In vivo magnetic resonance spectroscopy of human fetal neural transplants. NMR Biomed. 1999 Jun; 12(4):221-36. PMID: 10421914.
    Citations: 11     Fields:    Translation:Humans
  79. Lin A, Bluml S, Mamelak AN. Efficacy of proton magnetic resonance spectroscopy in clinical decision making for patients with suspected malignant brain tumors. J Neurooncol. 1999; 45(1):69-81. PMID: 10728912.
    Citations: 19     Fields:    Translation:HumansPHPublic Health
  80. Ross BD, Bluml S, Seymour KJ, Tan J, Hwang JH, Lin A. . Encyclopedia of Nuclear Magnetic Resonance, eds Grant DM and Harris RK. Systemically Induced Encephalopathies: Newer Clinical Applications of MRS. 1999.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.