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Alexander Peter Lin, Ph.D.

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Biography
2014
Young Mentor Award
2011
Clinical Research Excellence Award
2011
Partners in Excellence Team Award

Overview
Dr. Lin is the director of the Center for Clinical Spectroscopy at Brigham and Women’s Hospital and Assistant Professor of Radiology at Harvard Medical School. Dr. Lin is a graduate of the California Institute of Technology, where he completed his Masters degree in Bioengineering and his doctoral degree in Biochemistry and Molecular Biophysics. He began his training as a research associate in 1997 and was appointed Director of Clinical Services and Senior Scientist at the Magnetic Resonance Spectroscopy Unit at the Huntington Medical Research Institutes in 2003. Since that time, he has been a visiting research associate at the Center of MR Research at the University of Illinois Chicago. From 2007 to 2009, Dr. Lin had a research fellowship at the National Heart, Lung and Blood Institute at the National Institutes of Health in Bethesda, MD. Dr. Lin arrived at Brigham and Women’s Hospital in 2009.

Dr. Lin’s research interests include clinical applications of multinuclear magnetic resonance spectroscopy in the brain, breast, and liver, and cardiovascular magnetic resonance imaging. He was awarded the Young Investigator’s Award in 2003 for his work in 13C spectroscopy in Alzheimer’s disease and an NHLBI Fellows Research Award for his work in strain mapping of the carotid arteries in 2007. He was recently awarded a Congressionally Directed Medical Research Program grant from the Department of Defense to study mild traumatic brain injury and post-traumatic stress disorder in soldiers returning from the Iraq/Afghanistan wars. In addition, he has ongoing collaborations with the Boston University Center for Study of Traumatic Encephalopathy to examine the long-term effects of repetitive head injury using magnetic resonance spectroscopy. He has co-authored more than three dozen peer-reviewed publications, five book chapters, and 75+ conference abstracts.

Finally, Dr. Alexander Lin has also been recognized through awards and media reports for his efforts in supporting mentorship, particularly of students of diversity through the laboratory’s involvement in the Student Success Jobs Program and Harvard Catalyst summer research studies. He actively mentors Harvard Medical School students and received a Young Mentor Award from Harvard Medical School. Further, he is involved in education and training in several international workshops for MR spectroscopy.

Mentoring
Player Position, Impact Severity, and Brain Chemistry in Retired National Football League Athletes
Summer, 06/09/14 - 08/15/14
Magnetic Resonance Spectroscopy in mTBI and PTS
Summer, 06/08/15 - 08/14/15

Featured Content
  • Imaging Trauma

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 107 total Publications Show all
  1. Altaras C, Ly MT, Schultz O, Barr WB, Banks SJ, Wethe JV, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Zetterberg H, Blennow K, Ashton N, Peskind E, Cantu RC, Coleman MJ, Lin AP, Koerte IK, Bouix S, Daneshvar D, Dodick DW, Geda YE, Katz DL, Weller JL, Mez J, Palmisano JN, Martin B, Cummings JL, Reiman EM, Shenton ME, Stern RA, Alosco ML. Dispersion-based cognitive intra-individual variability in former American football players: Association with traumatic encephalopathy syndrome, repetitive head impacts, and biomarkers. Clin Neuropsychol. 2025 Jan 26; 1-29. PMID: 39865747.
    Citations: Article has an altmetric score of 2
    Fields: NeuNeurologyPsyPsychology
  2. Ly MT, Altaras C, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Zetterberg H, Blennow K, Peskind ER, Banks SJ, Barr WB, Wethe JV, Lenio S, Bondi MW, Delano-Wood LM, Cantu RC, Coleman MJ, Dodick DW, Mez J, Daneshvar DH, Palmisano JN, Martin B, Lin AP, Koerte IK, Bouix S, Cummings JL, Reiman EM, Shenton ME, Stern RA, Alosco ML. Single- versus two-test criteria for cognitive impairment: associations with CSF and imaging markers in former American football players. Clin Neuropsychol. 2025 Jan 20; 1-25. PMID: 39834028.
    Fields: NeuNeurologyPsyPsychology
  3. Zhou M, Nie Z, Zhao J, Xiao Y, Hong X, Wang Y, Dong C, Lin AP, Lei Z. Correction: Optimization and validation of echo times of point-resolved spectroscopy for cystathionine detection in gliomas. Cancer Imaging. 2024 Nov 21; 24(1):159. PMID: 39574156; PMCID: PMC11580482.
    Fields: DiaDiagnostic ImagingNeoNeoplasms
  4. Arciniega H, Baucom ZH, Tuz-Zahra F, Tripodis Y, John O, Carrington H, Kim N, Knyazhanskaya EE, Jung LB, Breedlove K, Wiegand TLT, Daneshvar DH, Rushmore RJ, Billah T, Pasternak O, Coleman MJ, Adler CH, Bernick C, Balcer LJ, Alosco ML, Koerte IK, Lin AP, Cummings JL, Reiman EM, Stern RA, Shenton ME, Bouix S. Brain morphometry in former American football players: findings from the DIAGNOSE CTE research project. Brain. 2024 Oct 03; 147(10):3596-3610. PMID: 38533783; PMCID: PMC11449133.
    Citations: Article has an altmetric score of 25
    Fields: BraBrainNeuNeurologyTranslation:Humans
  5. Zhou M, Nie Z, Zhao J, Xiao Y, Hong X, Wang Y, Dong C, Lin AP, Lei Z. Optimization and validation of echo times of point-resolved spectroscopy for cystathionine detection in gliomas. Cancer Imaging. 2024 Sep 02; 24(1):118. PMID: 39223589; PMCID: PMC11367870.
    Citations: 1
    Fields: DiaDiagnostic ImagingNeoNeoplasmsTranslation:Humans
  6. Fleischer CC, Lin AP, Allen JW. Reversal of National Coverage Determination for MR Spectroscopy Increases Reimbursement Rates. Radiol Imaging Cancer. 2024 Sep; 6(5):e240230. PMID: 39212523; PMCID: PMC11443472.
    Citations:
    Fields: NeoNeoplasmsRadRadiologyTranslation:Humans
  7. Arciniega H, Jung LB, Tuz-Zahra F, Tripodis Y, John O, Kim N, Carrington HW, Knyazhanskaya EE, Chamaria A, Breedlove K, Wiegand TLT, Daneshvar D, Billah T, Pasternak O, Coleman MJ, Adler CH, Bernick C, Balcer LJ, Alosco ML, Lin AP, Koerte IK, Cummings JL, Reiman EM, Stern RA, Bouix S, Shenton ME, DIAGNOSE CTE Research Project. Cavum Septum Pellucidum in Former American Football Players: Findings From the DIAGNOSE CTE Research Project. Neurol Clin Pract. 2024 Oct; 14(5):e200324. PMID: 39161749; PMCID: PMC11332980.
    Citations: 1 Article has an altmetric score of 3
  8. Jung LB, Wiegand TLT, Tuz-Zahra F, Tripodis Y, Iliff JJ, Piantino J, Arciniega H, Kim CL, Pankatz L, Bouix S, Lin AP, Alosco ML, Daneshvar DH, Mez J, Sepehrband F, Rathi Y, Pasternak O, Coleman MJ, Adler CH, Bernick C, Balcer L, Cummings JL, Reiman EM, Stern RA, Shenton ME, Koerte IK, DIAGNOSE CTE Research Project. Repetitive Head Impacts and Perivascular Space Volume in Former American Football Players. JAMA Netw Open. 2024 Aug 01; 7(8):e2428687. PMID: 39186275.
    Citations: Article has an altmetric score of 58
    Fields: MedMedicine (General)Translation:Humans
  9. Rahmani F, Batson RD, Zimmerman A, Reddigari S, Bigler ED, Lanning SC, Ilasa E, Grafman JH, Lu H, Lin AP, Raji CA. Rate of abnormalities in quantitative MR neuroimaging of persons with chronic traumatic brain injury. BMC Neurol. 2024 Jul 05; 24(1):235. PMID: 38969967; PMCID: PMC11225195.
    Citations: 1 Article has an altmetric score of 45
    Fields: NeuNeurologyTranslation:Humans
  10. Basaria S, Taplin ME, McDonnell M, Simonson DC, Lin AP, Dufour AB, Habtemariam D, Nguyen PL, Ravi P, Kibel AS, Sweeney CJ, D'Amico AV, Roberts DA, Xu W, Wei XX, Sunkara R, Choudhury AD, Mantia C, Beltran H, Pomerantz M, Berchuck JE, Martin NE, Leeman JE, Mouw KW, Kilbridge KE, Bearup R, Kackley H, Kafel H, Huang G, Reid KF, Storer T, Braga-Basaria M, Travison TG. Insulin resistance during androgen deprivation therapy in men with prostate cancer. Cancer. 2024 Nov 01; 130(21):3671-3685. PMID: 38881266; PMCID: PMC11464184.
    Citations: 1 Article has an altmetric score of 3
    Fields: NeoNeoplasmsTranslation:Humans
  11. Banks SJ, Yhang E, Tripodis Y, Su Y, Protas H, Adler CH, Balcer LJ, Bernick C, Mez JB, Palmisano J, Barr WB, Wethe JV, Dodick DW, Mcclean MD, Martin B, Hartlage K, Turner A, Turner RW, Malhotra A, Colman M, Pasternak O, Lin AP, Koerte IK, Bouix S, Cummings JL, Shenton ME, Reiman EM, Stern RA, Alosco ML. Clinical Outcomes and Tau Pathology in Retired Football Players: Associations With Diagnosed and Witnessed Sleep Apnea. Neurol Clin Pract. 2024 Apr; 14(2):e200263. PMID: 38425491; PMCID: PMC10900387.
  12. Ly MT, Tuz-Zahra F, Tripodis Y, Adler CH, Balcer LJ, Bernick C, Zetterberg H, Blennow K, Peskind ER, Au R, Banks SJ, Barr WB, Wethe JV, Bondi MW, Delano-Wood LM, Cantu RC, Coleman MJ, Dodick DW, McClean MD, Mez JB, Palmisano J, Martin B, Hartlage K, Lin AP, Koerte IK, Cummings JL, Reiman EM, Shenton ME, Stern RA, Bouix S, Alosco ML, for DIAGNOSE CTE Research Project. Association of Vascular Risk Factors and CSF and Imaging Biomarkers With White Matter Hyperintensities in Former American Football Players. Neurology. 2024 Jan 23; 102(2):e208030. PMID: 38165330; PMCID: PMC10870736.
    Citations: 3 Article has an altmetric score of 70
    Fields: NeuNeurology
  13. Lin AP. Cystathionine: A Spectroscopic Biomarker for 1p/19q Codeleted Gliomas. Radiology. 2023 09; 308(3):e232100. PMID: 37668521.
    Citations: 2 Article has an altmetric score of 3
    Fields: RadRadiologyTranslation:Humans
  14. Doose A, Tam FI, Hellerhoff I, King JA, Boehm I, Gottloeber K, Wahl H, Werner A, Raschke F, Bartnik-Olson B, Lin AP, Akgün K, Roessner V, Linn J, Ehrlich S. Triangulating brain alterations in anorexia nervosa: a multimodal investigation of magnetic resonance spectroscopy, morphometry and blood-based biomarkers. Transl Psychiatry. 2023 08 12; 13(1):277. PMID: 37573444; PMCID: PMC10423271.
    Citations: 2 Article has an altmetric score of 13
    Fields: PsyPsychiatryTranslation:Humans
  15. Busler JN, Slate SR, Liao H, Lyndon S, Taylor J, Lin AP, Mahon PB. Sex hormones as correlates of oxidative stress in the adult brain. Psychiatry Res Neuroimaging. 2023 09; 334:111681. PMID: 37540945; PMCID: PMC10548422.
    Citations: 1 Article has an altmetric score of 1
    Fields: DiaDiagnostic ImagingNeuNeurologyPsyPsychiatryTranslation:Humans
  16. Pencina KM, Valderrabano R, Wipper B, Orkaby AR, Reid KF, Storer T, Lin AP, Merugumala S, Wilson L, Latham N, Ghattas-Puylara C, Ozimek NE, Cheng M, Bhargava A, Memish-Beleva Y, Lawney B, Lavu S, Swain PM, Apte RS, Sinclair DA, Livingston D, Bhasin S. Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: A Physiologic Study. J Clin Endocrinol Metab. 2023 07 14; 108(8):1968-1980. PMID: 36740954; PMCID: PMC11491622.
    Citations: 12 Article has an altmetric score of 60
    Fields: EndEndocrinologyMetMetabolismTranslation:Humans
  17. Bonke EM, Bonfert MV, Hillmann SM, Seitz-Holland J, Gaubert M, Wiegand TLT, De Luca A, Cho KIK, Sandmo SB, Yhang E, Tripodis Y, Seer C, Kaufmann D, Kaufmann E, Muehlmann M, Gooijers J, Lin AP, Leemans A, Swinnen SP, Bahr R, Shenton ME, Pasternak O, Tacke U, Heinen F, Koerte IK. Neurological soft signs in adolescents are associated with brain structure. Cereb Cortex. 2023 04 25; 33(9):5547-5556. PMID: 36424865.
    Citations: Article has an altmetric score of 1
    Fields: BraBrainTranslation:Humans
  18. Esopenko C, Sollmann N, Bonke EM, Wiegand TLT, Heinen F, de Souza NL, Breedlove KM, Shenton ME, Lin AP, Koerte IK. Current and Emerging Techniques in Neuroimaging of Sport-Related Concussion. J Clin Neurophysiol. 2023 Jul 01; 40(5):398-407. PMID: 36930218; PMCID: PMC10329721.
    Citations: 4 Article has an altmetric score of 4
    Fields: NeuNeurologyPhyPhysiologyTranslation:Humans
  19. Harris AD, Amiri H, Bento M, Cohen R, Ching CRK, Cudalbu C, Dennis EL, Doose A, Ehrlich S, Kirov II, Mekle R, Oeltzschner G, Porges E, Souza R, Tam FI, Taylor B, Thompson PM, Quidé Y, Wilde EA, Williamson J, Lin AP, Bartnik-Olson B. Harmonization of multi-scanner in vivo magnetic resonance spectroscopy: ENIGMA consortium task group considerations. Front Neurol. 2022; 13:1045678. PMID: 36686533; PMCID: PMC9845632.
    Citations: 6 Article has an altmetric score of 9
  20. Ritland BM, Neumeier WH, Jiang SH, Smith CD, Heaton KJ, Hildebrandt AM, Jabbar MA, Liao HJ, Coello E, Zhao W, Bay CP, Lin AP. Short-term neurochemical effects of transcutaneous trigeminal nerve stimulation using 7T magnetic resonance spectroscopy. J Neuroimaging. 2023 03; 33(2):279-288. PMID: 36495053.
    Citations: 3 Article has an altmetric score of 1
    Fields: DiaDiagnostic ImagingNeuNeurologyTranslation:Humans
  21. Ravanfar P, Syeda WT, Jayaram M, Rushmore RJ, Moffat B, Lin AP, Lyall AE, Merritt AH, Yaghmaie N, Laskaris L, Luza S, Opazo CM, Liberg B, Chakravarty MM, Devenyi GA, Desmond P, Cropley VL, Makris N, Shenton ME, Bush AI, Velakoulis D, Pantelis C. In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia. Schizophrenia (Heidelb). 2022 Oct 26; 8(1):86. PMID: 36289238; PMCID: PMC9605948.
    Citations: 11 Article has an altmetric score of 27
  22. Alosco ML, Su Y, Stein TD, Protas H, Cherry JD, Adler CH, Balcer LJ, Bernick C, Pulukuri SV, Abdolmohammadi B, Coleman MJ, Palmisano JN, Tripodis Y, Mez J, Rabinovici GD, Marek KL, Beach TG, Johnson KA, Huber BR, Koerte I, Lin AP, Bouix S, Cummings JL, Shenton ME, Reiman EM, McKee AC, Stern RA, DIAGNOSE C. T. E. Research Project. Associations between near end-of-life flortaucipir PET and postmortem CTE-related tau neuropathology in six former American football players. Eur J Nucl Med Mol Imaging. 2023 01; 50(2):435-452. PMID: 36152064; PMCID: PMC9816291.
    Citations: 8 Article has an altmetric score of 18
    Fields: NucNuclear MedicinePhyPhysicsTranslation:Humans
  23. Alosco ML, Tripodis Y, Baucom ZH, Adler CH, Balcer LJ, Bernick C, Mariani ML, Au R, Banks SJ, Barr WB, Wethe JV, Cantu RC, Coleman MJ, Dodick DW, McClean MD, McKee AC, Mez J, Palmisano JN, Martin B, Hartlage K, Lin AP, Koerte IK, Cummings JL, Reiman EM, Stern RA, Shenton ME, Bouix S, DIAGNOSE CTE Research Project. White matter hyperintensities in former American football players. Alzheimers Dement. 2023 04; 19(4):1260-1273. PMID: 35996231; PMCID: PMC10351916.
    Citations: 8 Article has an altmetric score of 29
    Fields: NeuNeurologyPsyPsychiatryTranslation:Humans
  24. Kim S, Merugumala S, Lin AP. A uniformity correction method to reduce scan time for 7T sodium imaging of brain tumors. J Neuroimaging. 2022 11; 32(6):1062-1069. PMID: 35989449; PMCID: PMC9649857.
    Fields: DiaDiagnostic ImagingNeuNeurologyTranslation:Humans
  25. Busler JN, Coello E, Liao H, Taylor J, Zhao W, Holsen LM, Lin AP, Mahon PB. Perceived Stress, Cortical GABA, and Functional Connectivity Correlates: A Hypothesis-Generating Preliminary Study. Front Psychiatry. 2022; 13:802449. PMID: 35350427; PMCID: PMC8957825.
    Citations: 2 Article has an altmetric score of 2
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.