Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jeffrey Daniel Macklis, M.D., Dr.Sc.Tech.

Other Positions

Available: 10/22/18, Expires: 05/31/22

Depending on the student's background and extent of undergraduate research experience in neuroscience, developmental biology, molecular biology, and related fields, a four-year or five-year HMS/HST research project can be planned and undertaken.

Overcoming inhibition of axonal regeneration following spinal cord injury using subcellular RNA-proteome mapping in corticospinal neuron growth cones
Summer, 02/02/18 - 12/28/18
Molecular Development of Corticospinal Motor Neurons in vivo
Summer, 05/01/05 - 08/26/05
Computational Tools for Mapping Gene Regulatory Networks of Projection Neuron Subtype Differentiation
Summer, 05/30/07 - 08/30/07
Molecular Mechanisms of Cortical Projection Neuron Differentiation and Neurogenesis
Summer, 06/01/01 - 08/31/01
Genetic Expression Profile of Corticospinal Motor Neurons in Ctip2-deficient mice
Summer, 06/19/06 - 08/18/06

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS104055 (MACKLIS, JEFFREY D) Mar 15, 2020 - Jan 31, 2025
    Molecular development and diversity of callosal projection neurons
    Role: Principal Investigator
  2. R21NS104733 (MACKLIS, JEFFREY D) Dec 1, 2017 - Nov 30, 2019
    Novel BEAM and R26-BEACON recombinase-based systems for mosaic analysis of gene function
    Role: Principal Investigator
  3. DP1NS106665 (MACKLIS, JEFFREY D) Sep 30, 2017 - Jul 31, 2022
    Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and Regeneration
    Role: Principal Investigator
  4. R56NS093376 (MACKLIS, JEFFREY D) Apr 15, 2016 - Mar 31, 2018
    Molecular development and diversity of callosal projection neurons
    Role: Principal Investigator
  5. R01NS075672 (MACKLIS, JEFFREY D) May 1, 2012 - Jan 31, 2018
    Molecular Mechanisms of CTIP2 Function in Corticospinal Motor Neuron Development
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Engmann AK, Hatch JJ, Nanda P, Veeraraghavan P, Ozkan A, Poulopoulos A, Murphy AJ, Macklis JD. Neuronal subtype-specific growth cone and soma purification from mammalian CNS via fractionation and fluorescent sorting for subcellular analyses and spatial mapping of local transcriptomes and proteomes. Nat Protoc. 2022 02; 17(2):222-251. PMID: 35022617.
    Citations:    Fields:    Translation:Cells
  2. Sahni V, Itoh Y, Shnider SJ, Macklis JD. Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting. Cell Rep. 2021 10 19; 37(3):109842. PMID: 34686337.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Sahni V, Shnider SJ, Jabaudon D, Song JHT, Itoh Y, Greig LC, Macklis JD. Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting. Cell Rep. 2021 10 19; 37(3):109843. PMID: 34686320.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Sadegh C, Ebina W, Arvanites AC, Davidow LS, Rubin LL, Macklis JD. Synthetic modified Fezf2 mRNA (modRNA) with concurrent small molecule SIRT1 inhibition enhances refinement of cortical subcerebral/corticospinal neuron identity from mouse embryonic stem cells. PLoS One. 2021; 16(9):e0254113. PMID: 34473715.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Diaz JL, Siththanandan VB, Lu V, Gonzalez-Nava N, Pasquina L, MacDonald JL, Woodworth MB, Ozkan A, Nair R, He Z, Sahni V, Sarnow P, Palmer TD, Macklis JD, Tharin S. An evolutionarily acquired microRNA shapes development of mammalian cortical projections. Proc Natl Acad Sci U S A. 2020 11 17; 117(46):29113-29122. PMID: 33139574.
    Citations: 5     Fields:    Translation:AnimalsCells
  6. Ribeiro MC, Moore SM, Kishi N, Macklis JD, MacDonald JL. Vitamin D Supplementation Rescues Aberrant NF-?B Pathway Activation and Partially Ameliorates Rett Syndrome Phenotypes in Mecp2 Mutant Mice. eNeuro. 2020 May/Jun; 7(3). PMID: 32393583.
    Citations: 2     Fields:    Translation:HumansAnimals
  7. Poulopoulos A, Murphy AJ, Ozkan A, Davis P, Hatch J, Kirchner R, Macklis JD. Subcellular transcriptomes and proteomes of developing axon projections in the cerebral cortex. Nature. 2019 01; 565(7739):356-360. PMID: 30626971.
    Citations: 39     Fields:    Translation:AnimalsCells
  8. Wuttke TV, Markopoulos F, Padmanabhan H, Wheeler AP, Murthy VN, Macklis JD. Developmentally primed cortical neurons maintain fidelity of differentiation and establish appropriate functional connectivity after transplantation. Nat Neurosci. 2018 04; 21(4):517-529. PMID: 29507412.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. MacDonald JL, Fame RM, Gillis-Buck EM, Macklis JD. Caveolin1 Identifies a Specific Subpopulation of Cerebral Cortex Callosal Projection Neurons (CPN) Including Dual Projecting Cortical Callosal/Frontal Projection Neurons (CPN/FPN). eNeuro. 2018 Jan-Feb; 5(1). PMID: 29379878.
    Citations: 6     Fields:    Translation:AnimalsCells
  10. Frangeul L, Kehayas V, Sanchez-Mut JV, Fièvre S, Krishna-K K, Pouchelon G, Telley L, Bellone C, Holtmaat A, Gräff J, Macklis JD, Jabaudon D. Input-dependent regulation of excitability controls dendritic maturation in somatosensory thalamocortical neurons. Nat Commun. 2017 12 08; 8(1):2015. PMID: 29222517.
    Citations: 12     Fields:    Translation:AnimalsCells
  11. Shipman SL, Nivala J, Macklis JD, Church GM. CRISPR-Cas encoding of a digital movie into the genomes of a population of living bacteria. Nature. 2017 07 20; 547(7663):345-349. PMID: 28700573.
    Citations: 48     Fields:    Translation:Cells
  12. Itoh Y, Poulopoulos A, Macklis JD. Unfolding the Folding Problem of the Cerebral Cortex: Movin' and Groovin'. Dev Cell. 2017 05 22; 41(4):332-334. PMID: 28535368.
    Citations:    Fields:    Translation:AnimalsCells
  13. Fame RM, Dehay C, Kennedy H, Macklis JD. Subtype-Specific Genes that Characterize Subpopulations of Callosal Projection Neurons in Mouse Identify Molecularly Homologous Populations in Macaque Cortex. Cereb Cortex. 2017 Mar 01; 27(3):1817-1830. PMID: 26874185.
    Citations: 11     Fields:    Translation:AnimalsCells
  14. Rodriguez-Muela N, Litterman NK, Norabuena EM, Mull JL, Galazo MJ, Sun C, Ng SY, Makhortova NR, White A, Lynes MM, Chung WK, Davidow LS, Macklis JD, Rubin LL. Single-Cell Analysis of SMN Reveals Its Broader Role in Neuromuscular Disease. Cell Rep. 2017 02 07; 18(6):1484-1498. PMID: 28178525.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  15. Muralidharan B, Khatri Z, Maheshwari U, Gupta R, Roy B, Pradhan SJ, Karmodiya K, Padmanabhan H, Shetty AS, Balaji C, Kolthur-Seetharam U, Macklis JD, Galande S, Tole S. LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J Neurosci. 2017 01 04; 37(1):194-203. PMID: 28053041.
    Citations: 24     Fields:    Translation:AnimalsCells
  16. Chen Z, Lin K, Macklis JD, Al-Chalabi A. Proposed association between the hexanucleotide repeat of C9orf72 and opposability index of the thumb. Amyotroph Lateral Scler Frontotemporal Degener. 2017 05; 18(3-4):175-181. PMID: 28010125.
    Citations:    Fields:    Translation:AnimalsCells
  17. Smith EC, Luc S, Croney DM, Woodworth MB, Greig LC, Fujiwara Y, Nguyen M, Sher F, Macklis JD, Bauer DE, Orkin SH. Strict in vivo specificity of the Bcl11a erythroid enhancer. Blood. 2016 11 10; 128(19):2338-2342. PMID: 27707736.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  18. Galazo MJ, Emsley JG, Macklis JD. Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016 07 06; 91(1):90-106. PMID: 27321927.
    Citations: 18     Fields:    Translation:AnimalsCells
  19. Fame RM, MacDonald JL, Dunwoodie SL, Takahashi E, Macklis JD. Cited2 Regulates Neocortical Layer II/III Generation and Somatosensory Callosal Projection Neuron Development and Connectivity. J Neurosci. 2016 06 15; 36(24):6403-19. PMID: 27307230.
    Citations: 11     Fields:    Translation:AnimalsCells
  20. Shipman SL, Nivala J, Macklis JD, Church GM. Molecular recordings by directed CRISPR spacer acquisition. Science. 2016 Jul 29; 353(6298):aaf1175. PMID: 27284167.
    Citations: 52     Fields:    Translation:Cells
  21. Woodworth MB, Greig LC, Liu KX, Ippolito GC, Tucker HO, Macklis JD. Ctip1 Regulates the Balance between Specification of Distinct Projection Neuron Subtypes in Deep Cortical Layers. Cell Rep. 2016 05 03; 15(5):999-1012. PMID: 27117402.
    Citations: 29     Fields:    Translation:AnimalsCells
  22. Greig LC, Woodworth MB, Greppi C, Macklis JD. Ctip1 Controls Acquisition of Sensory Area Identity and Establishment of Sensory Input Fields in the Developing Neocortex. Neuron. 2016 04 20; 90(2):261-77. PMID: 27100196.
    Citations: 25     Fields:    Translation:AnimalsCells
  23. Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016 Apr; 19(4):542-53. PMID: 27021939.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  24. Kishi N, MacDonald JL, Ye J, Molyneaux BJ, Azim E, Macklis JD. Reduction of aberrant NF-?B signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice. Nat Commun. 2016 Jan 29; 7:10520. PMID: 26821816.
    Citations: 25     Fields:    Translation:AnimalsCells
  25. Jones AR, Troakes C, King A, Sahni V, De Jong S, Bossers K, Papouli E, Mirza M, Al-Sarraj S, Shaw CE, Shaw PJ, Kirby J, Veldink JH, Macklis JD, Powell JF, Al-Chalabi A. Stratified gene expression analysis identifies major amyotrophic lateral sclerosis genes. Neurobiol Aging. 2015 May; 36(5):2006.e1-9. PMID: 25801576.
    Citations: 11     Fields:    Translation:HumansCells
  26. Jara JH, Genç B, Cox GA, Bohn MC, Roos RP, Macklis JD, Ulupinar E, Özdinler PH. Corticospinal Motor Neurons Are Susceptible to Increased ER Stress and Display Profound Degeneration in the Absence of UCHL1 Function. Cereb Cortex. 2015 Nov; 25(11):4259-72. PMID: 25596590.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  27. Sadegh C, Macklis JD. Established monolayer differentiation of mouse embryonic stem cells generates heterogeneous neocortical-like neurons stalled at a stage equivalent to midcorticogenesis. J Comp Neurol. 2014 Aug 15; 522(12):Spc1. PMID: 24942076.
  28. Sadegh C, Macklis JD. Established monolayer differentiation of mouse embryonic stem cells generates heterogeneous neocortical-like neurons stalled at a stage equivalent to midcorticogenesis. J Comp Neurol. 2014 Aug 15; 522(12):2691-706. PMID: 24610556.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Greig LC, Woodworth MB, Galazo MJ, Padmanabhan H, Macklis JD. Molecular logic of neocortical projection neuron specification, development and diversity. Nat Rev Neurosci. 2013 11; 14(11):755-69. PMID: 24105342.
    Citations: 318     Fields:    Translation:HumansCells
  30. Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, van den Berg LH, Ringel S. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotroph Lateral Scler Frontotemporal Degener. 2013 May; 14 Suppl 1:5-18. PMID: 23678876.
    Citations: 63     Fields:    Translation:HumansCells
  31. Cederquist GY, Azim E, Shnider SJ, Padmanabhan H, Macklis JD. Lmo4 establishes rostral motor cortex projection neuron subtype diversity. J Neurosci. 2013 Apr 10; 33(15):6321-32. PMID: 23575831.
    Citations: 28     Fields:    Translation:AnimalsCells
  32. Woodworth MB, Greig LC, Kriegstein AR, Macklis JD. SnapShot: cortical development. Cell. 2012 Nov 09; 151(4):918-918.e1. PMID: 23141546.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  33. Tharin S, Kothapalli CR, Ozdinler PH, Pasquina L, Chung S, Varner J, DeValence S, Kamm R, Macklis JD. A microfluidic device to investigate axon targeting by limited numbers of purified cortical projection neuron subtypes. Integr Biol (Camb). 2012 Nov; 4(11):1398-405. PMID: 23034677.
    Citations: 2     Fields:    Translation:AnimalsCells
  34. Sohur US, Padmanabhan HK, Kotchetkov IS, Menezes JR, Macklis JD. Anatomic and molecular development of corticostriatal projection neurons in mice. Cereb Cortex. 2014 Feb; 24(2):293-303. PMID: 23118198.
    Citations: 38     Fields:    Translation:AnimalsCells
  35. Macklis JD. Human adult olfactory bulb neurogenesis? Novelty is the best policy. Neuron. 2012 May 24; 74(4):595-6. PMID: 22632715.
    Citations: 10     Fields:    
  36. Emsley JG, Menezes JR, Madeiro Da Costa RF, Martinez AM, Macklis JD. Identification of radial glia-like cells in the adult mouse olfactory bulb. Exp Neurol. 2012 Aug; 236(2):283-97. PMID: 22634209.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  37. Sohur US, Arlotta P, Macklis JD. Developmental Controls are Re-Expressed during Induction of Neurogenesis in the Neocortex of Young Adult Mice. Front Neurosci. 2012; 6:12. PMID: 22347158.
    Citations: 5     
  38. Czupryn A, Zhou YD, Chen X, McNay D, Anderson MP, Flier JS, Macklis JD. Transplanted hypothalamic neurons restore leptin signaling and ameliorate obesity in db/db mice. Science. 2011 Nov 25; 334(6059):1133-7. PMID: 22116886.
    Citations: 22     Fields:    Translation:AnimalsCells
  39. Jabaudon D, Shnider SJ, Tischfield DJ, Galazo MJ, Macklis JD. RORß induces barrel-like neuronal clusters in the developing neocortex. Cereb Cortex. 2012 May; 22(5):996-1006. PMID: 21799210.
    Citations: 42     Fields:    Translation:AnimalsCells
  40. Ozdinler PH, Benn S, Yamamoto TH, Güzel M, Brown RH, Macklis JD. Corticospinal motor neurons and related subcerebral projection neurons undergo early and specific neurodegeneration in hSOD1G?³A transgenic ALS mice. J Neurosci. 2011 Mar 16; 31(11):4166-77. PMID: 21411657.
    Citations: 86     Fields:    Translation:AnimalsCells
  41. Fame RM, MacDonald JL, Macklis JD. Development, specification, and diversity of callosal projection neurons. Trends Neurosci. 2011 Jan; 34(1):41-50. PMID: 21129791.
    Citations: 150     Fields:    Translation:HumansAnimalsCells
  42. Tomassy GS, De Leonibus E, Jabaudon D, Lodato S, Alfano C, Mele A, Macklis JD, Studer M. Area-specific temporal control of corticospinal motor neuron differentiation by COUP-TFI. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3576-81. PMID: 20133588.
    Citations: 51     Fields:    Translation:AnimalsCells
  43. Kishi N, Macklis JD. MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons. Exp Neurol. 2010 Mar; 222(1):51-8. PMID: 20025874.
    Citations: 56     Fields:    Translation:AnimalsCells
  44. Molyneaux BJ, Arlotta P, Fame RM, MacDonald JL, MacQuarrie KL, Macklis JD. Novel subtype-specific genes identify distinct subpopulations of callosal projection neurons. J Neurosci. 2009 Sep 30; 29(39):12343-54. PMID: 19793993.
    Citations: 92     Fields:    Translation:AnimalsCells
  45. Azim E, Jabaudon D, Fame RM, Macklis JD. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. Nat Neurosci. 2009 Oct; 12(10):1238-47. PMID: 19657336.
    Citations: 104     Fields:    Translation:AnimalsCells
  46. Azim E, Shnider SJ, Cederquist GY, Sohur US, Macklis JD. Lmo4 and Clim1 progressively delineate cortical projection neuron subtypes during development. Cereb Cortex. 2009 Jul; 19 Suppl 1:i62-9. PMID: 19366868.
    Citations: 35     Fields:    Translation:AnimalsCells
  47. Joshi PS, Molyneaux BJ, Feng L, Xie X, Macklis JD, Gan L. Bhlhb5 regulates the postmitotic acquisition of area identities in layers II-V of the developing neocortex. Neuron. 2008 Oct 23; 60(2):258-72. PMID: 18957218.
    Citations: 88     Fields:    Translation:AnimalsCells
  48. Lai T, Jabaudon D, Molyneaux BJ, Azim E, Arlotta P, Menezes JR, Macklis JD. SOX5 controls the sequential generation of distinct corticofugal neuron subtypes. Neuron. 2008 Jan 24; 57(2):232-47. PMID: 18215621.
    Citations: 147     Fields:    Translation:AnimalsCells
  49. Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci. 2008 Jan 16; 28(3):622-32. PMID: 18199763.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  50. Magavi SS, Macklis JD. Immunocytochemical analysis of neuronal differentiation. Methods Mol Biol. 2008; 438:345-52. PMID: 18369769.
    Citations: 9     Fields:    Translation:AnimalsCells
  51. Magavi SS, Macklis JD. Identification of newborn cells by BrdU labeling and immunocytochemistry in vivo. Methods Mol Biol. 2008; 438:335-43. PMID: 18369768.
    Citations: 13     Fields:    Translation:Animals
  52. Catapano LA, Magavi SS, Macklis JD. Neuroanatomical tracing of neuronal projections with Fluoro-Gold. Methods Mol Biol. 2008; 438:353-9. PMID: 18369770.
    Citations: 6     Fields:    Translation:AnimalsCells
  53. Gao X, Arlotta P, Macklis JD, Chen J. Conditional knock-out of beta-catenin in postnatal-born dentate gyrus granule neurons results in dendritic malformation. J Neurosci. 2007 Dec 26; 27(52):14317-25. PMID: 18160639.
    Citations: 45     Fields:    Translation:AnimalsCells
  54. Breunig JJ, Arellano JI, Macklis JD, Rakic P. Everything that glitters isn't gold: a critical review of postnatal neural precursor analyses. Cell Stem Cell. 2007 Dec 13; 1(6):612-27. PMID: 18371403.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  55. Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD. Neuronal subtype specification in the cerebral cortex. Nat Rev Neurosci. 2007 Jun; 8(6):427-37. PMID: 17514196.
    Citations: 724     Fields:    Translation:HumansAnimalsCells
  56. Molyneaux BJ, Arlotta P, Macklis JD. Molecular development of corticospinal motor neuron circuitry. Novartis Found Symp. 2007; 288:3-15; discussion 15-20, 96-8. PMID: 18494249.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  57. Ozdinler PH, Macklis JD. IGF-I specifically enhances axon outgrowth of corticospinal motor neurons. Nat Neurosci. 2006 Nov; 9(11):1371-81. PMID: 17057708.
    Citations: 159     Fields:    Translation:AnimalsCells
  58. Sohur US, Emsley JG, Mitchell BD, Macklis JD. Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells. Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29; 361(1473):1477-97. PMID: 16939970.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  59. Emsley JG, Macklis JD. Astroglial heterogeneity closely reflects the neuronal-defined anatomy of the adult murine CNS. Neuron Glia Biol. 2006 Aug; 2(3):175-86. PMID: 17356684.
    Citations: 132     Fields:    
  60. Steele AD, Emsley JG, Ozdinler PH, Lindquist S, Macklis JD. Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3416-21. PMID: 16492732.
    Citations: 116     Fields:    Translation:AnimalsCells
  61. Magavi SS, Mitchell BD, Szentirmai O, Carter BS, Macklis JD. Adult-born and preexisting olfactory granule neurons undergo distinct experience-dependent modifications of their olfactory responses in vivo. J Neurosci. 2005 Nov 16; 25(46):10729-39. PMID: 16291946.
    Citations: 87     Fields:    Translation:AnimalsCells
  62. Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification of corticospinal motor neurons. Neuron. 2005 Sep 15; 47(6):817-31. PMID: 16157277.
    Citations: 226     Fields:    Translation:AnimalsCells
  63. Kishi N, Macklis JD. Dissecting MECP2 function in the central nervous system. J Child Neurol. 2005 Sep; 20(9):753-9. PMID: 16225831.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  64. Arlotta P, Macklis JD. Archeo-cell biology: carbon dating is not just for pots and dinosaurs. Cell. 2005 Jul 15; 122(1):4-6. PMID: 16009125.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  65. Emsley JG, Mitchell BD, Kempermann G, Macklis JD. Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells. Prog Neurobiol. 2005 Apr; 75(5):321-41. PMID: 15913880.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  66. Mitchell BD, Macklis JD. Large-scale maintenance of dual projections by callosal and frontal cortical projection neurons in adult mice. J Comp Neurol. 2005 Jan 31; 482(1):17-32. PMID: 15612019.
    Citations: 42     Fields:    Translation:AnimalsCells
  67. Arlotta P, Molyneaux BJ, Chen J, Inoue J, Kominami R, Macklis JD. Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo. Neuron. 2005 Jan 20; 45(2):207-21. PMID: 15664173.
    Citations: 512     Fields:    Translation:AnimalsCells
  68. Chen J, Magavi SS, Macklis JD. Neurogenesis of corticospinal motor neurons extending spinal projections in adult mice. Proc Natl Acad Sci U S A. 2004 Nov 16; 101(46):16357-62. PMID: 15534207.
    Citations: 76     Fields:    Translation:AnimalsCells
  69. Kishi N, Macklis JD. MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol Cell Neurosci. 2004 Nov; 27(3):306-21. PMID: 15519245.
    Citations: 212     Fields:    Translation:AnimalsCells
  70. Emsley JG, Mitchell BD, Magavi SS, Arlotta P, Macklis JD. The repair of complex neuronal circuitry by transplanted and endogenous precursors. NeuroRx. 2004 Oct; 1(4):452-71. PMID: 15717047.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  71. Catapano LA, Arlotta P, Cage TA, Macklis JD. Stage-specific and opposing roles of BDNF, NT-3 and bFGF in differentiation of purified callosal projection neurons toward cellular repair of complex circuitry. Eur J Neurosci. 2004 May; 19(9):2421-34. PMID: 15128396.
    Citations: 12     Fields:    Translation:AnimalsCells
  72. Emsley JG, Arlotta P, Macklis JD. Star-cross'd neurons: astroglial effects on neural repair in the adult mammalian CNS. Trends Neurosci. 2004 May; 27(5):238-40. PMID: 15111002.
    Citations: 14     Fields:    Translation:AnimalsCells
  73. Mitchell BD, Emsley JG, Magavi SS, Arlotta P, Macklis JD. Constitutive and induced neurogenesis in the adult mammalian brain: manipulation of endogenous precursors toward CNS repair. Dev Neurosci. 2004 Mar-Aug; 26(2-4):101-17. PMID: 15711054.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  74. Mellough CB, Cui Q, Spalding KL, Symons NA, Pollett MA, Snyder EY, Macklis JD, Harvey AR. Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells. Exp Neurol. 2004 Mar; 186(1):6-19. PMID: 14980806.
    Citations: 14     Fields:    Translation:AnimalsCells
  75. Eyding D, Macklis JD, Neubacher U, Funke K, Wörgötter F. Selective elimination of corticogeniculate feedback abolishes the electroencephalogram dependence of primary visual cortical receptive fields and reduces their spatial specificity. J Neurosci. 2003 Aug 06; 23(18):7021-33. PMID: 12904463.
    Citations: 10     Fields:    Translation:AnimalsCells
  76. Arlotta P, Magavi SS, Macklis JD. Induction of adult neurogenesis: molecular manipulation of neural precursors in situ. Ann N Y Acad Sci. 2003 Jun; 991:229-36. PMID: 12846990.
    Citations: 6     Fields:    Translation:AnimalsCells
  77. Arlotta P, Magavi SS, Macklis JD. Molecular manipulation of neural precursors in situ: induction of adult cortical neurogenesis. Exp Gerontol. 2003 Jan-Feb; 38(1-2):173-82. PMID: 12543275.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  78. Wörgötter F, Eyding D, Macklis JD, Funke K. The influence of the corticothalamic projection on responses in thalamus and cortex. Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29; 357(1428):1823-34. PMID: 12626015.
    Citations: 13     Fields:    Translation:Animals
  79. Fricker-Gates RA, Shin JJ, Tai CC, Catapano LA, Macklis JD. Late-stage immature neocortical neurons reconstruct interhemispheric connections and form synaptic contacts with increased efficiency in adult mouse cortex undergoing targeted neurodegeneration. J Neurosci. 2002 May 15; 22(10):4045-56. PMID: 12019324.
    Citations: 23     Fields:    Translation:AnimalsCells
  80. Magavi SS, Macklis JD. Induction of neuronal type-specific neurogenesis in the cerebral cortex of adult mice: manipulation of neural precursors in situ. Brain Res Dev Brain Res. 2002 Mar 31; 134(1-2):57-76. PMID: 11947937.
    Citations: 11     Fields:    Translation:AnimalsCells
  81. Magavi SS, Macklis JD. Identification of newborn cells by BrdU labeling and immunocytochemistry in vivo. Methods Mol Biol. 2002; 198:283-90. PMID: 11951629.
    Citations: 4     Fields:    Translation:AnimalsCells
  82. Catapano LA, Magavi SS, Macklis JD. Neuroanatomical tracing of neuronal projections with Fluoro-Gold. Methods Mol Biol. 2002; 198:299-304. PMID: 11951632.
    Citations: 2     Fields:    Translation:AnimalsCells
  83. Magavi SS, Macklis JD. Immunocytochemical analysis of neuronal differentiation. Methods Mol Biol. 2002; 198:291-7. PMID: 11951631.
    Citations: 2     Fields:    Translation:AnimalsCells
  84. Magavi SS, Macklis JD. Manipulation of neural precursors in situ: induction of neurogenesis in the neocortex of adult mice. Neuropsychopharmacology. 2001 Dec; 25(6):816-35. PMID: 11750176.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  85. Catapano LA, Arnold MW, Perez FA, Macklis JD. Specific neurotrophic factors support the survival of cortical projection neurons at distinct stages of development. J Neurosci. 2001 Nov 15; 21(22):8863-72. PMID: 11698598.
    Citations: 32     Fields:    Translation:AnimalsCells
  86. Macklis JD. Neurobiology: New memories from new neurons. Nature. 2001 Mar 15; 410(6826):314-5, 317. PMID: 11268187.
    Citations: 4     Fields:    Translation:AnimalsCells
  87. Shin JJ, Fricker-Gates RA, Perez FA, Leavitt BR, Zurakowski D, Macklis JD. Transplanted neuroblasts differentiate appropriately into projection neurons with correct neurotransmitter and receptor phenotype in neocortex undergoing targeted projection neuron degeneration. J Neurosci. 2000 Oct 01; 20(19):7404-16. PMID: 11007899.
    Citations: 18     Fields:    Translation:AnimalsCells
  88. Magavi SS, Leavitt BR, Macklis JD. Induction of neurogenesis in the neocortex of adult mice. Nature. 2000 Jun 22; 405(6789):951-5. PMID: 10879536.
    Citations: 297     Fields:    Translation:AnimalsCells
  89. Scharff C, Kirn JR, Grossman M, Macklis JD, Nottebohm F. Targeted neuronal death affects neuronal replacement and vocal behavior in adult songbirds. Neuron. 2000 Feb; 25(2):481-92. PMID: 10719901.
    Citations: 90     Fields:    Translation:AnimalsCells
  90. Gates MA, Tai CC, Macklis JD. Neocortical neurons lacking the protein-tyrosine kinase B receptor display abnormal differentiation and process elongation in vitro and in vivo. Neuroscience. 2000; 98(3):437-47. PMID: 10869838.
    Citations: 15     Fields:    Translation:AnimalsCells
  91. Gates MA, Fricker-Gates RA, Macklis JD. Reconstruction of cortical circuitry. Prog Brain Res. 2000; 127:115-56. PMID: 11142025.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  92. Catapano LA, Sheen VL, Leavitt BR, Macklis JD. Differentiation of transplanted neural precursors varies regionally in adults striatum. Neuroreport. 1999 Dec 16; 10(18):3971-7. PMID: 10716243.
    Citations:    Fields:    Translation:HumansAnimalsCells
  93. Sheen VL, Arnold MW, Wang Y, Macklis JD. Neural precursor differentiation following transplantation into neocortex is dependent on intrinsic developmental state and receptor competence. Exp Neurol. 1999 Jul; 158(1):47-62. PMID: 10448417.
    Citations: 13     Fields:    Translation:AnimalsCells
  94. Leavitt BR, Hernit-Grant CS, Macklis JD. Mature astrocytes transform into transitional radial glia within adult mouse neocortex that supports directed migration of transplanted immature neurons. Exp Neurol. 1999 May; 157(1):43-57. PMID: 10222107.
    Citations: 36     Fields:    Translation:AnimalsCells
  95. Lanier LM, Gates MA, Witke W, Menzies AS, Wehman AM, Macklis JD, Kwiatkowski D, Soriano P, Gertler FB. Mena is required for neurulation and commissure formation. Neuron. 1999 Feb; 22(2):313-25. PMID: 10069337.
    Citations: 142     Fields:    Translation:AnimalsCells
  96. Wang Y, Sheen VL, Macklis JD. Cortical interneurons upregulate neurotrophins in vivo in response to targeted apoptotic degeneration of neighboring pyramidal neurons. Exp Neurol. 1998 Dec; 154(2):389-402. PMID: 9878177.
    Citations: 13     Fields:    Translation:AnimalsCells
  97. Snyder EY, Yoon C, Flax JD, Macklis JD. Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortex. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11663-8. PMID: 9326667.
    Citations: 83     Fields:    Translation:AnimalsCells
  98. Hernit-Grant CS, Macklis JD. Embryonic neurons transplanted to regions of targeted photolytic cell death in adult mouse somatosensory cortex re-form specific callosal projections. Exp Neurol. 1996 May; 139(1):131-42. PMID: 8635560.
    Citations: 12     Fields:    Translation:AnimalsCells
  99. Sheen VL, Macklis JD. Targeted neocortical cell death in adult mice guides migration and differentiation of transplanted embryonic neurons. J Neurosci. 1995 Dec; 15(12):8378-92. PMID: 8613770.
    Citations: 17     Fields:    Translation:AnimalsCells
  100. Snyder EY, Macklis JD. Multipotent neural progenitor or stem-like cells may be uniquely suited for therapy for some neurodegenerative conditions. Clin Neurosci. 1995-1996; 3(5):310-6. PMID: 8914798.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  101. Sheen VL, Macklis JD. Apoptotic mechanisms in targeted neuronal cell death by chromophore-activated photolysis. Exp Neurol. 1994 Nov; 130(1):67-81. PMID: 7821398.
    Citations: 11     Fields:    Translation:AnimalsCells
  102. Macklis JD. Transplanted neocortical neurons migrate selectively into regions of neuronal degeneration produced by chromophore-targeted laser photolysis. J Neurosci. 1993 Sep; 13(9):3848-63. PMID: 8366349.
    Citations: 26     Fields:    Translation:AnimalsCells
  103. Madison RD, Macklis JD. Noninvasively induced degeneration of neocortical pyramidal neurons in vivo: selective targeting by laser activation of retrogradely transported photolytic chromophore. Exp Neurol. 1993 Jun; 121(2):153-9. PMID: 8339767.
    Citations: 6     Fields:    Translation:AnimalsCells
  104. Sheen VL, Dreyer EB, Macklis JD. Calcium-mediated neuronal degeneration following singlet oxygen production. Neuroreport. 1992 Aug; 3(8):705-8. PMID: 1520860.
    Citations: 1     Fields:    Translation:AnimalsCells
  105. Macklis RM, Macklis JD. Historical and phrenologic reflections on the nonmotor functions of the cerebellum: love under the tent? Neurology. 1992 Apr; 42(4):928-32. PMID: 1565255.
    Citations: 1     Fields:    Translation:Humans
  106. Liu GT, Carrazana EJ, Macklis JD, Mikati MA. Delayed oculogyric crises associated with striatocapsular infarction. J Clin Neuroophthalmol. 1991 Sep; 11(3):198-201. PMID: 1836805.
    Citations: 2     Fields:    Translation:Humans
  107. Macklis JD, Madison RD. Neuroblastoma grafts are noninvasively removed within mouse neocortex by selective laser activation of intracellular photolytic chromophore. J Neurosci. 1991 Jul; 11(7):2055-62. PMID: 2066774.
    Citations: 4     Fields:    Translation:AnimalsCells
  108. Macklis JD, Quattrochi JJ. Restricted diffusion and stability of carbachol-fluorescent nanospheres in-vivo. Neuroreport. 1991 May; 2(5):247-50. PMID: 1912455.
    Citations: 4     Fields:    Translation:AnimalsCells
  109. Madison R, Macklis JD, Thies C. Latex nanosphere delivery system (LNDS): novel nanometer-sized carriers of fluorescent dyes and active agents selectively target neuronal subpopulations via uptake and retrograde transport. Brain Res. 1990 Jul 02; 522(1):90-8. PMID: 2224519.
    Citations: 2     Fields:    Translation:AnimalsCells
  110. Macklis JD, Madison RD. Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity. J Neurosci Methods. 1990 Jan; 31(1):43-6. PMID: 2308380.
    Citations: 38     Fields:    Translation:AnimalsCells
  111. Quattrochi JJ, Mamelak AN, Madison RD, Macklis JD, Hobson JA. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Science. 1989 Sep 01; 245(4921):984-6. PMID: 2475910.
    Citations: 21     Fields:    Translation:AnimalsCells
  112. Schick RM, Jolesz F, Barnes PD, Macklis JD. MR diagnosis of dural venous sinus thrombosis complicating L-asparaginase therapy. Comput Med Imaging Graph. 1989 Jul-Aug; 13(4):319-27. PMID: 2743289.
    Citations: 2     Fields:    Translation:Humans
  113. Madison RD, Macklis JD, Frosch MP. Non-invasive laser microsurgery selectively damages populations of labeled mouse neurons: dependence on incident laser dose and absorption. Brain Res. 1988 Mar 29; 445(1):101-10. PMID: 3365549.
    Citations: 1     Fields:    Translation:AnimalsCells
  114. Brasier AR, Macklis JD, Vaughan D, Warner L, Kirshenbaum JM. Myopericarditis as an initial presentation of meningococcemia. Unusual manifestation of infection with serotype W135. Am J Med. 1987 Mar 23; 82(3 Spec No):641-4. PMID: 3103444.
    Citations: 6     Fields:    Translation:HumansCells
  115. Macklis JD, Madison R. Unfocused laser illumination kills dye-targeted mouse neurons by selective photothermolysis. Brain Res. 1985 Dec 16; 359(1-2):158-65. PMID: 3841019.
    Citations:    Fields:    Translation:Animals
  116. Anderson P, Macklis J, Brown M, Ory D. Eosinophilic cerebrospinal fluid pleocytosis and cryptococcal meningitis. Ann Intern Med. 1985 Aug; 103(2):306-7. PMID: 4014918.
    Citations: 2     Fields:    Translation:Humans
  117. Macklis JD, Sidman RL, Shine HD. Cross-linked collagen surface for cell culture that is stable, uniform, and optically superior to conventional surfaces. In Vitro Cell Dev Biol. 1985 Mar; 21(3 Pt 1):189-94. PMID: 3859483.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  118. Macklis JD, Ketterer FD, Cravalho EG. Temperature dependence of the microwave properties of aqueous solutions of ethylene glycol between +15 degrees C and -70 degrees C. Cryobiology. 1979 Jun; 16(3):272-86. PMID: 477370.
    Citations: 1     Fields:    Translation:Cells
  119. Macklis JD, Ketterer FD. Microwave properties of cryoprotectants. Cryobiology. 1978 Dec; 15(6):627-35. PMID: 743887.
    Citations: 2     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.