Harvard Catalyst Profiles

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Jeffrey Daniel Macklis, Dipl.ScNat, Dr.Sc.Tech, M.D.

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Mentoring
completed student projects
Overcoming inhibition of axonal regeneration following spinal cord injury using subcellular RNA-proteome mapping in corticospinal neuron growth cones
Summer, 02/02/18 - 12/28/18
Molecular Development of Corticospinal Motor Neurons in vivo
Summer, 05/01/05 - 08/26/05
Computational Tools for Mapping Gene Regulatory Networks of Projection Neuron Subtype Differentiation
Summer, 05/30/07 - 08/30/07
Molecular Mechanisms of Cortical Projection Neuron Differentiation and Neurogenesis
Summer, 06/01/01 - 08/31/01
Genetic Expression Profile of Corticospinal Motor Neurons in Ctip2-deficient mice
Summer, 06/19/06 - 08/18/06

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21NS141110 (MACKLIS, JEFFREY D) Sep 20, 2024 - Sep 19, 2026
    NIH
    Synthetic System for Neuron Subtype- and Context-Specific Subcellular RNA/Protein Manipulation and Bioactive Delivery
    Role: Principal Investigator
  2. RF1AG083085 (MACKLIS, JEFFREY D) Sep 1, 2023 - Aug 31, 2026
    NIH
    Subcellular mechanisms of subtype-specific neuron vulnerability in ALS and FTD: dysregulation of synapse-localized RNA, protein, and translation in mouse models and human cortico-spinal assembloids
    Role: Principal Investigator
  3. R01NS104055 (MACKLIS, JEFFREY D) Mar 15, 2020 - Jan 31, 2025
    NIH
    Molecular development and diversity of callosal projection neurons
    Role: Principal Investigator
  4. R21NS104733 (MACKLIS, JEFFREY D) Dec 1, 2017 - Nov 30, 2019
    NIH
    Novel BEAM and R26-BEACON recombinase-based systems for mosaic analysis of gene function
    Role: Principal Investigator
  5. DP1NS106665 (MACKLIS, JEFFREY D) Sep 30, 2017 - Jul 31, 2022
    NIH
    Subcellular RNA-Proteome Mapping in Subtype- and Circuit-Specific Growth Cones: Development, Cell Biology, Disease, and Regeneration
    Role: Principal Investigator

Bibliographic
selected publications
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.