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Adam B. Lerner, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher A, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med. 2018 09; 24(9):1351-1359. PMID: 30127395.
    Citations:    Fields:    
  2. Stolla M, Chang S, Schulman S, Bauer K, Haspel R, Lerner AB. Use of thromboelastography in the management of a patient with acquired von Willebrand disease undergoing cardiac bypass surgery. Br J Haematol. 2018 04; 181(1):143-145. PMID: 28106909.
    Citations:    Fields:    
  3. Hai T, Lerner AB, Khamooshian A. Severe Tricuspid Valve Injury During Right Ventricular Lead Extraction. J Cardiothorac Vasc Anesth. 2017 04; 31(2):626-628. PMID: 27989376.
    Citations:    Fields:    Translation:Humans
  4. Andersen LW, Holmberg MJ, Berg KM, Chase M, Cocchi MN, Sulmonte C, Balkema J, MacDonald M, Montissol S, Senthilnathan V, Liu D, Khabbaz K, Lerner A, Novack V, Liu X, Donnino MW. Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial. Crit Care. 2016 Mar 14; 20:92. PMID: 27044557.
    Citations: 2     Fields:    Translation:Humans
  5. Andersen LW, Holmberg MJ, Doherty M, Khabbaz K, Lerner A, Berg KM, Donnino MW. Postoperative Lactate Levels and Hospital Length of Stay After Cardiac Surgery. J Cardiothorac Vasc Anesth. 2015 Dec; 29(6):1454-60. PMID: 26456273.
    Citations: 3     Fields:    Translation:Humans
  6. Karkouti K, Grocott HP, Hall R, Jessen ME, Kruger C, Lerner AB, MacAdams C, Mazer CD, de Medicis É, Myles P, Ralley F, Rheault MR, Rochon A, Slaughter MS, Sternlicht A, Syed S, Waters T. Interrelationship of preoperative anemia, intraoperative anemia, and red blood cell transfusion as potentially modifiable risk factors for acute kidney injury in cardiac surgery: a historical multicentre cohort study. Can J Anaesth. 2015 Apr; 62(4):377-84. PMID: 25537735.
    Citations: 9     Fields:    Translation:Humans
  7. Foss F, Advani R, Duvic M, Hymes KB, Intragumtornchai T, Lekhakula A, Shpilberg O, Lerner A, Belt RJ, Jacobsen ED, Laurent G, Ben-Yehuda D, Beylot-Barry M, Hillen U, Knoblauch P, Bhat G, Chawla S, Allen LF, Pohlman B. A Phase II trial of Belinostat (PXD101) in patients with relapsed or refractory peripheral or cutaneous T-cell lymphoma. Br J Haematol. 2015 Mar; 168(6):811-9. PMID: 25404094.
    Citations: 29     Fields:    Translation:HumansCTClinical Trials
  8. Tapan U, Pestana JB, Lee JC, Lerner A. Epstein-Barr virus-associated diffuse large B-cell lymphoma arising in atrial myxoma: a proposal for a modified therapeutic approach. Leuk Lymphoma. 2015 Feb; 56(2):505-7. PMID: 24794809.
    Citations: 1     Fields:    Translation:HumansCells
  9. Subramaniam B, Khabbaz KR, Heldt T, Lerner AB, Mittleman MA, Davis RB, Goldberger AL, Costa MD. Blood pressure variability: can nonlinear dynamics enhance risk assessment during cardiovascular surgery? J Cardiothorac Vasc Anesth. 2014 Apr; 28(2):392-7. PMID: 24508020.
    Citations: 4     Fields:    Translation:Humans
  10. Subramaniam B, Lerner A, Novack V, Khabbaz K, Paryente-Wiesmann M, Hess P, Talmor D. Increased glycemic variability in patients with elevated preoperative HbA1C predicts adverse outcomes following coronary artery bypass grafting surgery. Anesth Analg. 2014 Feb; 118(2):277-87. PMID: 24445629.
    Citations: 8     Fields:    Translation:Humans
  11. McNeil J, Lerner AB. Standard thromboelastography should not be used to assess candidacy for neuraxial procedures in patients taking P2Y12 inhibitors. Anesthesiology. 2013 Oct; 119(4):993. PMID: 24195884.
    Citations:    Fields:    Translation:Humans
  12. Mahmood F, Hess PE, Matyal R, Mackensen GB, Wang A, Qazi A, Panzica PJ, Lerner AB, Maslow A. Echocardiographic anatomy of the mitral valve: a critical appraisal of 2-dimensional imaging protocols with a 3-dimensional perspective. J Cardiothorac Vasc Anesth. 2012 Oct; 26(5):777-84. PMID: 22841527.
    Citations: 1     Fields:    Translation:Humans
  13. Makkinje A, Vanden Borre P, Near RI, Patel PS, Lerner A. Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas). J Biol Chem. 2012 Aug 10; 287(33):27703-14. PMID: 22711540.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Sundar S, Novack V, Jervis K, Bender SP, Lerner A, Panzica P, Mahmood F, Malhotra A, Talmor D. Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients. Anesthesiology. 2011 May; 114(5):1102-10. PMID: 21430518.
    Citations: 24     Fields:    Translation:Humans
  15. Vanden Borre P, Near RI, Makkinje A, Mostoslavsky G, Lerner A. BCAR3/AND-34 can signal independent of complex formation with CAS family members or the presence of p130Cas. Cell Signal. 2011 Jun; 23(6):1030-40. PMID: 21262352.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  16. Pugsley J, Lerner AB. Cardiac output monitoring: is there a gold standard and how do the newer technologies compare? Semin Cardiothorac Vasc Anesth. 2010 Dec; 14(4):274-82. PMID: 21059611.
    Citations: 13     Fields:    Translation:Humans
  17. Mahmood F, Gorman JH, Subramaniam B, Gorman RC, Panzica PJ, Hagberg RC, Lerner AB, Hess PE, Maslow A, Khabbaz KR. Changes in mitral valve annular geometry after repair: saddle-shaped versus flat annuloplasty rings. Ann Thorac Surg. 2010 Oct; 90(4):1212-20. PMID: 20868816.
    Citations: 17     Fields:    Translation:Humans
  18. Xavier A, Erlich J, Lerner AB. Coronary artery bypass graft surgery and moderate aortic stenosis: when to leave well enough alone. J Cardiothorac Vasc Anesth. 2010 Aug; 24(4):712-3. PMID: 20673750.
    Citations:    Fields:    Translation:Humans
  19. Subramaniam B; Gerstle J; Jidge S; Mahmood F; Lerner A; Khabbaz K . Major perioperative adverse events following cardiac surgery in patients with impaired glucose tolerance. Anesthesia & Analgesia. 2010; 110(3).
  20. Hashim B, Lerner AB. The FloTrac system--measurement of stroke volume and the assessment of dynamic fluid loading. Int Anesthesiol Clin. 2010; 48(1):45-56. PMID: 20065726.
    Citations: 2     Fields:    Translation:Humans
  21. Makkinje A, Near RI, Infusini G, Vanden Borre P, Bloom A, Cai D, Costello CE, Lerner A. AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern. Cell Signal. 2009 Sep; 21(9):1423-35. PMID: 19454314.
    Citations: 13     Fields:    Translation:HumansCells
  22. Meyers JA, Su DW, Lerner A. Chronic lymphocytic leukemia and B and T cells differ in their response to cyclic nucleotide phosphodiesterase inhibitors. J Immunol. 2009 May 01; 182(9):5400-11. PMID: 19380787.
    Citations: 12     Fields:    Translation:HumansCells
  23. Near RI, Smith RS, Toselli PA, Freddo TF, Bloom AB, Vanden Borre P, Seldin DC, Lerner A. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009; 15:685-99. PMID: 19365570.
    Citations: 13     Fields:    Translation:AnimalsCells
  24. Jervis K, Senthilnathan V, Lerner AB. Management of a patient with lupus anticoagulant and antiphospholipid syndrome for off-pump coronary artery bypass grafting using the Hepcon system. Anesth Analg. 2009 Apr; 108(4):1116-9. PMID: 19299773.
    Citations: 1     Fields:    Translation:Humans
  25. Matyal R, Grinberg AO, Panzica PJ, Darke M, Lerner AB, Fisher L, Campbell D, Mahmood F. Heparin administration during cardiopulmonary resuscitation. J Cardiothorac Vasc Anesth. 2008 Dec; 22(6):861-3. PMID: 18834837.
    Citations:    Fields:    Translation:Humans
  26. Karthik S; Mahmood F; Subramaniam B; Panzica P; Lerner A; Jervis K; DeLatorre R. Changes in mitral valve geometry following repair of ischemic mitral regurgitation. Anesthesia & Analgesia. 2008; 106(6):118.
  27. Matyal R; Mahmood F; Lerner A; Pawlowski J; Panzica P; Mitchell J; Karthik S; Subramaniam B; Leckie R; DeCamp M; Gangadharan S; Hess P. Transesophageal assessment of right ventricular function during one lung ventilation in noncardiac thoracic surgery. Anesthesia & Analgesia. 2008; 106(6):5.
  28. Mahmood F, Karthik S, Subramaniam B, Panzica PJ, Mitchell J, Lerner AB, Jervis K, Maslow AD. Intraoperative application of geometric three-dimensional mitral valve assessment package: a feasibility study. J Cardiothorac Vasc Anesth. 2008 Apr; 22(2):292-8. PMID: 18375338.
    Citations: 10     Fields:    Translation:Humans
  29. Karthik S, Sundar S, Lerner A, Panzica P, Subramaniam B, Mahmood F. Intraoperative assessment of perivalvular mitral regurgitation: utility of three-dimensional echocardiography. J Cardiothorac Vasc Anesth. 2008 Jun; 22(3):431-4. PMID: 18503935.
    Citations: 1     Fields:    Translation:Humans
  30. Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A. AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology. J Cell Physiol. 2007 Sep; 212(3):655-65. PMID: 17427198.
    Citations: 18     Fields:    Translation:HumansCells
  31. Meyers JA, Taverna J, Chaves J, Makkinje A, Lerner A. Phosphodiesterase 4 inhibitors augment levels of glucocorticoid receptor in B cell chronic lymphocytic leukemia but not in normal circulating hematopoietic cells. Clin Cancer Res. 2007 Aug 15; 13(16):4920-7. PMID: 17699872.
    Citations: 11     Fields:    Translation:Humans
  32. Oren-Grinberg A, Lerner AB, Talmor D. Echocardiography in the Intensive Care Unit. Procedures, Techniques, and Minimally Invasive Monitoring in Intensive Care Medicine. 2007; 323-336.
  33. Oren-Grinberg A, Lerner AB, Talmor D. Echocardiography in the Intensive Care Unit. Irwin and Rippe’s Intensive Care Medicine. 2007; 289-302.
  34. Mahmood F, Matyal R, Subramaniam B, Mitchell J, Pomposelli F, Lerner AB, Maslow A, Hess PM. Transmitral flow propagation velocity and assessment of diastolic function during abdominal aortic aneurysm repair. J Cardiothorac Vasc Anesth. 2007 Aug; 21(4):486-91. PMID: 17678772.
    Citations: 3     Fields:    Translation:Humans
  35. Lerner AB. Aprotinin's effect on ACT is not an artifact. Anesth Analg. 2007 May; 104(5):1302; author reply 1302-3. PMID: 17456701.
    Citations:    Fields:    Translation:Humans
  36. Mahmood F; Oren-Grinberg A; Subramaniam B; Karthik S; Lerner A; Panzica P; DeLatorre R. Utility of three dimensional echocardiography for assessment of mitral regurgitation. Anesthesia & Analgesia. 2007; 104:SCA88.
  37. Karthik S; Subramaniam B; Mahmood F; Legedza A; Panzica P; Lerner A. Optimal TEE view to measure C-sept, AL/ PL ratios and intercommisural distances in mitral valve surgery . Anesthesia & Analgesia. 2007; 104:SCA102.
  38. Mineva ND, Rothstein TL, Meyers JA, Lerner A, Sonenshein GE. CD40 ligand-mediated activation of the de novo RelB NF-kappaB synthesis pathway in transformed B cells promotes rescue from apoptosis. J Biol Chem. 2007 Jun 15; 282(24):17475-85. PMID: 17446175.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  39. Subramaniam B, Panzica PJ, Pawlowski JB, Ramanavarapu V, Pomposelli FB, De La Torre R, Lerner AB. Epidural blood patch for acute subdural hematoma after spinal catheter drainage during hybrid thoracoabdominal aneurysm repair. J Cardiothorac Vasc Anesth. 2007 Oct; 21(5):704-8. PMID: 17905278.
    Citations:    Fields:    Translation:Humans
  40. Robina Matyal, Feroze Mahmood, Peter Panzica, John Mitchell, and Adam Lerner . Pulmonary Artery Catheter Misplacement. Anesth Analg. 2007; 104:456-7.
  41. Karthik S, Mahmood F, Panzica PJ, Khabbaz KR, Lerner AB. Intraoperative transesophageal echocardiographic visualization of a left anterior descending coronary artery aneurysm. Anesth Analg. 2007 Feb; 104(2):263-4. PMID: 17242077.
    Citations: 1     Fields:    Translation:Humans
  42. Everett PC, Meyers JA, Makkinje A, Rabbi M, Lerner A. Preclinical assessment of curcumin as a potential therapy for B-CLL. Am J Hematol. 2007 Jan; 82(1):23-30. PMID: 16947318.
    Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
  43. Lerner AB. Pro: Antifibrinolytics are safe and effective in patients undergoing liver transplantation. J Cardiothorac Vasc Anesth. 2006 Dec; 20(6):888-90. PMID: 17138101.
    Citations:    Fields:    Translation:Humans
  44. Lerner AB, Subramaniam B, Mahmood F, Khabbaz KR. An unusual echodensity in the ascending aorta: transesophageal echocardiographic visualization of a protruding coronary stent. Anesth Analg. 2006 Oct; 103(4):854-5. PMID: 17000792.
    Citations:    Fields:    Translation:Humans
  45. Joan E. Spiegel, Amanda D. Kindred, Adam B. Lerner. Anesthesia: Keywords Defined. 2006.
  46. Mahmood F, Lerner AB, Matyal R, Karthik S, Maslow AD. Dobutamine stress echocardiography and intraoperative assessment of mitral valve. J Cardiothorac Vasc Anesth. 2006 Dec; 20(6):867-71. PMID: 17138098.
    Citations:    Fields:    Translation:Humans
  47. Lerner A, Epstein PM. Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J. 2006 Jan 01; 393(Pt 1):21-41. PMID: 16336197.
    Citations: 38     Fields:    Translation:Humans
  48. Lerner AB, Mashikian J, Haering M, Comunale M. Introduction to the Cardiac Room. 2005.
  49. Lerner AB, Sundar E, Mahmood F, Sarge T, Hanto DW, Panzica PJ. Four cases of cardiopulmonary thromboembolism during liver transplantation without the use of antifibrinolytic drugs. Anesth Analg. 2005 Dec; 101(6):1608-12. PMID: 16301227.
    Citations: 6     Fields:    Translation:Humans
  50. Koido S, Nikrui N, Ohana M, Xia J, Tanaka Y, Liu C, Durfee JK, Lerner A, Gong J. Assessment of fusion cells from patient-derived ovarian carcinoma cells and dendritic cells as a vaccine for clinical use. Gynecol Oncol. 2005 Nov; 99(2):462-71. PMID: 16137749.
    Citations: 14     Fields:    Translation:HumansCells
  51. Felekkis KN, Narsimhan RP, Near R, Castro AF, Zheng Y, Quilliam LA, Lerner A. AND-34 activates phosphatidylinositol 3-kinase and induces anti-estrogen resistance in a SH2 and GDP exchange factor-like domain-dependent manner. Mol Cancer Res. 2005 Jan; 3(1):32-41. PMID: 15671247.
    Citations: 20     Fields:    Translation:HumansCells
  52. Tiwari S, Dong H, Kim EJ, Weintraub L, Epstein PM, Lerner A. Type 4 cAMP phosphodiesterase (PDE4) inhibitors augment glucocorticoid-mediated apoptosis in B cell chronic lymphocytic leukemia (B-CLL) in the absence of exogenous adenylyl cyclase stimulation. Biochem Pharmacol. 2005 Feb 01; 69(3):473-83. PMID: 15652238.
    Citations: 12     Fields:    Translation:HumansCells
  53. Koido S, Ohana M, Liu C, Nikrui N, Durfee J, Lerner A, Gong J. Dendritic cells fused with human cancer cells: morphology, antigen expression, and T cell stimulation. Clin Immunol. 2004 Dec; 113(3):261-9. PMID: 15507391.
    Citations: 17     Fields:    Translation:HumansCells
  54. Tiwari S, Felekkis K, Moon EY, Flies A, Sherr DH, Lerner A. Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis. Blood. 2004 Apr 01; 103(7):2661-7. PMID: 14615375.
    Citations: 23     Fields:    Translation:HumansCells
  55. Lerner A, Dinardo JA, Comunale ME. Anesthetic management for repair of Ebstein's anomaly. J Cardiothorac Vasc Anesth. 2003 Apr; 17(2):232-5. PMID: 12698409.
    Citations:    Fields:    Translation:Humans
  56. Zhao X, Mashikian JS, Panzica P, Lerner A, Park KW, Comunale ME. Comparison of thermodilution bolus cardiac output and Doppler cardiac output in the early post-cardiopulmonary bypass period. J Cardiothorac Vasc Anesth. 2003 Apr; 17(2):193-8. PMID: 12698401.
    Citations: 3     Fields:    Translation:Humans
  57. Moon EY, Lerner A. PDE4 inhibitors activate a mitochondrial apoptotic pathway in chronic lymphocytic leukemia cells that is regulated by protein phosphatase 2A. Blood. 2003 May 15; 101(10):4122-30. PMID: 12531792.
    Citations: 21     Fields:    Translation:HumansCells
  58. Cai D, Felekkis KN, Near RI, O'Neill GM, van Seventer JM, Golemis EA, Lerner A. The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42. J Immunol. 2003 Jan 15; 170(2):969-78. PMID: 12517963.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  59. Moon EY, Lerner A. Benzylamide sulindac analogues induce changes in cell shape, loss of microtubules and G(2)-M arrest in a chronic lymphocytic leukemia (CLL) cell line and apoptosis in primary CLL cells. Cancer Res. 2002 Oct 15; 62(20):5711-9. PMID: 12384529.
    Citations: 1     Fields:    Translation:HumansCells
  60. Lee R, Wolda S, Moon E, Esselstyn J, Hertel C, Lerner A. PDE7A is expressed in human B-lymphocytes and is up-regulated by elevation of intracellular cAMP. Cell Signal. 2002 Mar; 14(3):277-84. PMID: 11812656.
    Citations: 11     Fields:    Translation:HumansCells
  61. Moon E, Lee R, Near R, Weintraub L, Wolda S, Lerner A. Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia. Clin Cancer Res. 2002 Feb; 8(2):589-95. PMID: 11839681.
    Citations: 19     Fields:    Translation:HumansCells
  62. Panzica P, Lerner A. Introduction to the Liver Transplant Operating Room. 2000.
  63. Chuang ML, Parker RA, Riley MF, Reilly MA, Johnson RB, Korley VJ, Lerner AB, Douglas PS. Three-dimensional echocardiography improves accuracy and compensates for sonographer inexperience in assessment of left ventricular ejection fraction. J Am Soc Echocardiogr. 1999 May; 12(5):290-9. PMID: 10231614.
    Citations: 5     Fields:    Translation:Humans
  64. Pomerantzeff PM, Brandao CM, Cauduro P, Puig LB, Grinberg M, Tarasoutchi F, Cardoso LF, Lerner A, Stolf NA, Verginelli G, Jatene AD. Fisics-Incor bovine pericardial bioprostheses: 15 year results. Heart Surg Forum. 1998; 1(2):130-5. PMID: 11276451.
    Citations: 2     Fields:    Translation:HumansAnimals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.