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Jeffrey E Saffitz, M.D., Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01HL136463 (SAFFITZ, JEFFREY E) Jul 15, 2018 - Jun 30, 2022
    NIH/NHLBI
    Altered Cell-Cell Coupling in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator
  2. R01HL116906 (TOWBIN, JEFFREY ALLEN) Aug 23, 2013 - Jun 30, 2017
    NIH/NHLBI
    Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
    Role: Co-Principal Investigator
  3. R01HL102361 (SAFFITZ, JEFFREY E) Apr 1, 2010 - Mar 31, 2014
    NIH/NHLBI
    Disease Mechanisms in ARVC
    Role: Principal Investigator
  4. RC1HL100110 (SAFFITZ, JEFFREY E) Sep 30, 2009 - Aug 31, 2012
    NIH/NHLBI
    Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator
  5. R01HL058507 (SAFFITZ, JEFFREY E) Apr 1, 1998 - Dec 31, 2008
    NIH/NHLBI
    Cx43 in a Genetic Model of Altered Myocardial Conduction
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Thiene G, Saffitz JE. Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now. Circulation. 2018 Jun 19; 137(25):2683-2685. PMID: 29915093.
    View in: PubMed
  2. Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 Apr; 4(4):504-514. PMID: 30067491.
    View in: PubMed
  3. Saffitz JE. Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2017 May - Jun; 28:51-58. PMID: 28319834.
    View in: PubMed
  4. Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz J, Arany Z. Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRß. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H662-H671. PMID: 28130335.
    View in: PubMed
  5. Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP. Central role for GSK3ß in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016 Apr 21; 1(5). PMID: 27170944.
    View in: PubMed
  6. Almomani R, Verhagen JM, Herkert JC, Brosens E, van Spaendonck-Zwarts KY, Asimaki A, van der Zwaag PA, Frohn-Mulder IM, Bertoli-Avella AM, Boven LG, van Slegtenhorst MA, van der Smagt JJ, van IJcken WF, Timmer B, van Stuijvenberg M, Verdijk RM, Saffitz JE, du Plessis FA, Michels M, Hofstra RM, Sinke RJ, van Tintelen JP, Wessels MW, Jongbloed JD, van de Laar IM. Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy. J Am Coll Cardiol. 2016 Feb 09; 67(5):515-25. PMID: 26846950.
    View in: PubMed
  7. Asimaki A, Protonotarios A, James CA, Chelko SP, Tichnell C, Murray B, Tsatsopoulou A, Anastasakis A, te Riele A, Kléber AG, Judge DP, Calkins H, Saffitz JE. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003688. PMID: 26850880; PMCID: PMC4785796 [Available on 02/01/17].
    View in: PubMed, PubMed Central
  8. Siqueira WC, da Cruz SG, Asimaki A, Saffitz JE, Moreira Mda C, Brasileiro G, Rocha LO. Cardiac sarcoidosis with severe involvement of the right ventricle: a case report. Autops Case Rep. 2015 Oct-Dec; 5(4):53-63. PMID: 26894046; PMCID: PMC4757920.
    View in: PubMed, PubMed Central
  9. Saffitz JE, Corradi D. The electrical heart: 25 years of discovery in cardiac electrophysiology, arrhythmias and sudden death. Cardiovasc Pathol. 2016 Mar-Apr; 25(2):149-57. PMID: 26764149.
    View in: PubMed
  10. Spezzacatene A, Sinagra G, Merlo M, Barbati G, Graw SL, Brun F, Slavov D, Di Lenarda A, Salcedo EE, Towbin JA, Saffitz JE, Marcus FI, Zareba W, Taylor MR, Mestroni L. Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life-Threatening Arrhythmias. J Am Heart Assoc. 2015 Oct 16; 4(10):e002149. PMID: 26475296.
    View in: PubMed
  11. Ahmad T, Yin P, Saffitz J, Pockros PJ, Lalezari J, Shiffman M, Freilich B, Zamparo J, Brown K, Dimitrova D, Kumar M, Manion D, Heath-Chiozzi M, Wolf R, Hughes E, Muir AJ, Hernandez AF. Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C. Hepatology. 2015 Aug; 62(2):409-16. PMID: 25251156.
    View in: PubMed
  12. Asimaki A, Kleber AG, Saffitz JE. Pathogenesis of Arrhythmogenic Cardiomyopathy. Can J Cardiol. 2015 Nov; 31(11):1313-24. PMID: 26199027; PMCID: PMC4619183 [Available on 11/01/16].
    View in: PubMed, PubMed Central
  13. Saffitz JE. Protein trafficking in cardiovascular disease: How the science has evolved and where it must go. Trends Cardiovasc Med. 2015 Jul; 25(5):390-1. PMID: 25666491.
    View in: PubMed
  14. Asimaki A, Kléber AG, MacRae CA, Saffitz JE. Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery. Prog Pediatr Cardiol. 2014 Dec 01; 37(1-2):3-7. PMID: 25506190.
    View in: PubMed
  15. Kleber AG, Saffitz JE. Role of the intercalated disc in cardiac propagation and arrhythmogenesis. Front Physiol. 2014; 5:404. PMID: 25368581; PMCID: PMC4201087.
    View in: PubMed, PubMed Central
  16. Hariharan V, Asimaki A, Michaelson JE, Plovie E, MacRae CA, Saffitz JE, Huang H. Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion. Cardiovasc Res. 2014 Nov 01; 104(2):280-9. PMID: 25253076; PMCID: PMC4296114.
    View in: PubMed, PubMed Central
  17. Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JE. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci Transl Med. 2014 Jun 11; 6(240):240ra74. PMID: 24920660; PMCID: PMC4471875.
    View in: PubMed, PubMed Central
  18. Saffitz JE, Sanders SP. Postmortem analysis of structural heart defects in fetuses and children by magnetic resonance imaging: an alternative to autopsy? Circulation. 2014 May 13; 129(19):1909-11. PMID: 24647276.
    View in: PubMed
  19. Corradi D, Callegari S, Manotti L, Ferrara D, Goldoni M, Alinovi R, Pinelli S, Mozzoni P, Andreoli R, Asimaki A, Pozzoli A, Becchi G, Mutti A, Benussi S, Saffitz JE, Alfieri O. Persistent lone atrial fibrillation: clinicopathologic study of 19 cases. Heart Rhythm. 2014 Jul; 11(7):1250-8. PMID: 24560692.
    View in: PubMed
  20. Asimaki A, Saffitz JE. Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy. Cell Commun Adhes. 2014 Feb; 21(1):13-23. PMID: 24460198; PMCID: PMC4466113.
    View in: PubMed, PubMed Central
  21. Haspel RL, Saffitz JE. Genomic oncology education: an urgent need, a new approach. Cancer J. 2014 Jan-Feb; 20(1):91-5. PMID: 24445771; PMCID: PMC3924419.
    View in: PubMed, PubMed Central
  22. Noorman M, Hakim S, Asimaki A, Vreeker A, van Rijen HV, van der Heyden MA, de Jonge N, de Weger RA, Hauer RN, Saffitz JE, van Veen TA. Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations. Cardiovasc Pathol. 2013 Sep-Oct; 22(5):314-8. PMID: 23688911.
    View in: PubMed
  23. Park JK, Rosen A, Saffitz JE, Asimaki A, Litovsky SH, Mackey-Bojack SM, Halushka MK. Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis. Rheumatology (Oxford). 2013 Aug; 52(8):1529-33. PMID: 23674817.
    View in: PubMed
  24. Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm. 2013 Mar; 10(3):412-9. PMID: 23178689.
    View in: PubMed
  25. Noorman M, Groeneweg JA, Asimaki A, Rizzo S, Papegaaij M, van Stuijvenberg L, de Jonge N, Dooijes D, Basso C, Saffitz JE, van Veen TA, Vink A, Hauer RN. End stage of arrhythmogenic cardiomyopathy with severe involvement of the interventricular septum. Heart Rhythm. 2013 Feb; 10(2):283-9. PMID: 23085127.
    View in: PubMed
  26. Saffitz JE, Kléber AG. Gap junctions, slow conduction, and ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 2012 Sep 18; 60(12):1111-3. PMID: 22883635.
    View in: PubMed
  27. van der Zwaag PA, van Rijsingen IA, Asimaki A, Jongbloed JD, van Veldhuisen DJ, Wiesfeld AC, Cox MG, van Lochem LT, de Boer RA, Hofstra RM, Christiaans I, van Spaendonck-Zwarts KY, Lekanne dit Deprez RH, Judge DP, Calkins H, Suurmeijer AJ, Hauer RN, Saffitz JE, Wilde AA, van den Berg MP, van Tintelen JP. Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy. Eur J Heart Fail. 2012 Nov; 14(11):1199-207. PMID: 22820313; PMCID: PMC3475434.
    View in: PubMed, PubMed Central
  28. Saffitz JE. Genomic pathology: a disruptive innovation. Per Med. 2012 May; 9(3):237-239. PMID: 29758788.
    View in: PubMed
  29. Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. Circ Res. 2012 May 25; 110(11):1445-53. PMID: 22518032; PMCID: PMC3381798.
    View in: PubMed, PubMed Central
  30. Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, Tinker A, Lambiase PD. Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur Heart J. 2012 Aug; 33(15):1942-53. PMID: 22240500; PMCID: PMC3409421.
    View in: PubMed, PubMed Central
  31. Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, Saffitz JE, Duffy HS, Ackerman MJ. Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation. 2012 Jan 24; 125(3):474-81. PMID: 22179534; PMCID: PMC3332541.
    View in: PubMed, PubMed Central
  32. Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d'Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL. 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol. 2012 Jul-Aug; 21(4):245-74. PMID: 22137237.
    View in: PubMed
  33. Asimaki A, Saffitz JE. Gap junctions and arrhythmogenic cardiomyopathy. Heart Rhythm. 2012 Jun; 9(6):992-5. PMID: 22100709; PMCID: PMC3358518.
    View in: PubMed, PubMed Central
  34. Gehmlich K, Syrris P, Reimann M, Asimaki A, Ehler E, Evans A, Quarta G, Pantazis A, Saffitz JE, McKenna WJ. Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele. Cardiovasc Pathol. 2012 Jul-Aug; 21(4):275-82. PMID: 22036071.
    View in: PubMed
  35. Saffitz JE. Arrhythmogenic cardiomyopathy: advances in diagnosis and disease pathogenesis. Circulation. 2011 Oct 11; 124(15):e390-2. PMID: 21986778.
    View in: PubMed
  36. Asimaki A, Tandri H, Duffy ER, Winterfield JR, Mackey-Bojack S, Picken MM, Cooper LT, Wilber DJ, Marcus FI, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, Stevenson WG, McKenna WJ, Gautam S, Remick DG, Calkins H, Saffitz JE. Altered desmosomal proteins in granulomatous myocarditis and potential pathogenic links to arrhythmogenic right ventricular cardiomyopathy. Circ Arrhythm Electrophysiol. 2011 Oct; 4(5):743-52. PMID: 21859801; PMCID: PMC3203520.
    View in: PubMed, PubMed Central
  37. Razani B, Zhang H, Schulze PC, Schilling JD, Verbsky J, Lodhi IJ, Topkara VK, Feng C, Coleman T, Kovacs A, Kelly DP, Saffitz JE, Dorn GW, Nichols CG, Semenkovich CF. Fatty acid synthase modulates homeostatic responses to myocardial stress. J Biol Chem. 2011 Sep 02; 286(35):30949-61. PMID: 21757749; PMCID: PMC3162454.
    View in: PubMed, PubMed Central
  38. Tonellato PJ, Crawford JM, Boguski MS, Saffitz JE. A national agenda for the future of pathology in personalized medicine: report of the proceedings of a meeting at the Banbury Conference Center on genome-era pathology, precision diagnostics, and preemptive care: a stakeholder summit. Am J Clin Pathol. 2011 May; 135(5):668-72. PMID: 21502420; PMCID: PMC4629248.
    View in: PubMed, PubMed Central
  39. Gehmlich K, Lambiase PD, Asimaki A, Ciaccio EJ, Ehler E, Syrris P, Saffitz JE, McKenna WJ. A novel desmocollin-2 mutation reveals insights into the molecular link between desmosomes and gap junctions. Heart Rhythm. 2011 May; 8(5):711-8. PMID: 21220045; PMCID: PMC3085091.
    View in: PubMed, PubMed Central
  40. Saffitz JE. The pathobiology of arrhythmogenic cardiomyopathy. Annu Rev Pathol. 2011; 6:299-321. PMID: 21073337.
    View in: PubMed
  41. Asimaki A, Saffitz JE. The role of endomyocardial biopsy in ARVC: looking beyond histology in search of new diagnostic markers. J Cardiovasc Electrophysiol. 2011 Jan; 22(1):111-7. PMID: 21235662; PMCID: PMC3058333.
    View in: PubMed, PubMed Central
  42. Gehmlich K, Syrris P, Peskett E, Evans A, Ehler E, Asimaki A, Anastasakis A, Tsatsopoulou A, Vouliotis AI, Stefanadis C, Saffitz JE, Protonotarios N, McKenna WJ. Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Cardiovasc Res. 2011 Apr 01; 90(1):77-87. PMID: 21062920; PMCID: PMC3058729.
    View in: PubMed, PubMed Central
  43. Samedi V, White S, Zimarowski MJ, Harris A, Saffitz J, Wang HH. Metastatic peritoneal mesothelioma in the setting of recurrent ascites: a case report. Diagn Cytopathol. 2010 Sep; 38(9):675-81. PMID: 20049974.
    View in: PubMed
  44. Gehmlich K, Asimaki A, Cahill TJ, Ehler E, Syrris P, Zachara E, Re F, Avella A, Monserrat L, Saffitz JE, McKenna WJ. Novel missense mutations in exon 15 of desmoglein-2: role of the intracellular cadherin segment in arrhythmogenic right ventricular cardiomyopathy? Heart Rhythm. 2010 Oct; 7(10):1446-53. PMID: 20708101; PMCID: PMC2994644.
    View in: PubMed, PubMed Central
  45. Haspel RL, Arnaout R, Briere L, Kantarci S, Marchand K, Tonellato P, Connolly J, Boguski MS, Saffitz JE. A call to action: training pathology residents in genomics and personalized medicine. Am J Clin Pathol. 2010 Jun; 133(6):832-4. PMID: 20472839.
    View in: PubMed
  46. Otten E, Asimaki A, Maass A, van Langen IM, van der Wal A, de Jonge N, van den Berg MP, Saffitz JE, Wilde AA, Jongbloed JD, van Tintelen JP. Desmin mutations as a cause of right ventricular heart failure affect the intercalated disks. Heart Rhythm. 2010 Aug; 7(8):1058-64. PMID: 20423733.
    View in: PubMed
  47. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the Task Force Criteria. Eur Heart J. 2010 Apr; 31(7):806-14. PMID: 20172912.
    View in: PubMed
  48. Marcus FI, McKenna WJ, Sherrill D, Basso C, Bauce B, Bluemke DA, Calkins H, Corrado D, Cox MG, Daubert JP, Fontaine G, Gear K, Hauer R, Nava A, Picard MH, Protonotarios N, Saffitz JE, Sanborn DM, Steinberg JS, Tandri H, Thiene G, Towbin JA, Tsatsopoulou A, Wichter T, Zareba W. Diagnosis of arrhythmogenic right ventricular cardiomyopathy/dysplasia: proposed modification of the task force criteria. Circulation. 2010 Apr 06; 121(13):1533-41. PMID: 20172911.
    View in: PubMed
  49. Xu T, Yang Z, Vatta M, Rampazzo A, Beffagna G, Pilichou K, Pillichou K, Scherer SE, Saffitz J, Kravitz J, Zareba W, Danieli GA, Lorenzon A, Nava A, Bauce B, Thiene G, Basso C, Calkins H, Gear K, Marcus F, Towbin JA. Compound and digenic heterozygosity contributes to arrhythmogenic right ventricular cardiomyopathy. J Am Coll Cardiol. 2010 Feb 09; 55(6):587-97. PMID: 20152563; PMCID: PMC2852685.
    View in: PubMed, PubMed Central
  50. Saffitz JE, Asimaki A, Huang H. Arrhythmogenic right ventricular cardiomyopathy: new insights into mechanisms of disease. Cardiovasc Pathol. 2010 May-Jun; 19(3):166-70. PMID: 20051321.
    View in: PubMed
  51. Saffitz JE, Asimaki A, Huang H. Arrhythmogenic right ventricular cardiomyopathy: new insights into disease mechanisms and diagnosis. J Investig Med. 2009 Dec; 57(8):861-4. PMID: 19952894.
    View in: PubMed
  52. Saffitz JE, Macrae CA. Mutations in desmosomal protein genes and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm. 2010 Jan; 7(1):30-2. PMID: 20129282.
    View in: PubMed
  53. Saffitz JE. Desmosome mutations in arrhythmogenic right ventricular cardiomyopathy: important insight but only part of the picture. Circ Cardiovasc Genet. 2009 Oct; 2(5):415-7. PMID: 20031615.
    View in: PubMed
  54. van Tintelen JP, Van Gelder IC, Asimaki A, Suurmeijer AJ, Wiesfeld AC, Jongbloed JD, van den Wijngaard A, Kuks JB, van Spaendonck-Zwarts KY, Notermans N, Boven L, van den Heuvel F, Veenstra-Knol HE, Saffitz JE, Hofstra RM, van den Berg MP. Severe cardiac phenotype with right ventricular predominance in a large cohort of patients with a single missense mutation in the DES gene. Heart Rhythm. 2009 Nov; 6(11):1574-83. PMID: 19879535.
    View in: PubMed
  55. Asimaki A, Tandri H, Huang H, Halushka MK, Gautam S, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, McKenna WJ, Calkins H, Saffitz JE. A new diagnostic test for arrhythmogenic right ventricular cardiomyopathy. N Engl J Med. 2009 Mar 12; 360(11):1075-84. PMID: 19279339.
    View in: PubMed
  56. Saffitz JE. Arrhythmogenic cardiomyopathy and abnormalities of cell-to-cell coupling. Heart Rhythm. 2009 Aug; 6(8 Suppl):S62-5. PMID: 19541548.
    View in: PubMed
  57. Tandri H, Asimaki A, Abraham T, Dalal D, Tops L, Jain R, Saffitz JE, Judge DP, Russell SD, Halushka M, Bluemke DA, Kass DA, Calkins H. Prolonged RV endocardial activation duration: a novel marker of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm. 2009 Jun; 6(6):769-75. PMID: 19419906.
    View in: PubMed
  58. Saffitz JE. Expanding the spectrum of arrhythmogenic cardiomyopathy. J Am Coll Cardiol. 2008 Dec 16; 52(25):2188-9. PMID: 19095137.
    View in: PubMed
  59. Huang H, Asimaki A, Lo D, McKenna W, Saffitz J. Disparate effects of different mutations in plakoglobin on cell mechanical behavior. Cell Motil Cytoskeleton. 2008 Dec; 65(12):964-78. PMID: 18937352; PMCID: PMC2650236.
    View in: PubMed, PubMed Central
  60. Asimaki A, Syrris P, Ward D, Guereta LG, Saffitz JE, McKenna WJ. Unique epidermolytic bullous dermatosis with associated lethal cardiomyopathy related to novel desmoplakin mutations. J Cutan Pathol. 2009 May; 36(5):553-9. PMID: 19178614.
    View in: PubMed
  61. Tandri H, Asimaki A, Dalal D, Saffitz JE, Halushka MK, Calkins H. Gap junction remodeling in a case of arrhythmogenic right ventricular dysplasia due to plakophilin-2 mutation. J Cardiovasc Electrophysiol. 2008 Nov; 19(11):1212-4. PMID: 18554203.
    View in: PubMed
  62. Saffitz JE. Sympathetic neural activity and the pathogenesis of sudden cardiac death. Heart Rhythm. 2008 Jan; 5(1):140-1. PMID: 18083070.
    View in: PubMed
  63. Asimaki A, Syrris P, Wichter T, Matthias P, Saffitz JE, McKenna WJ. A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet. 2007 Nov; 81(5):964-73. PMID: 17924338; PMCID: PMC2265660.
    View in: PubMed, PubMed Central
  64. Sundset R, Ytrehus K, Zhang Y, Saffitz JE, Yamada KA. Repeated simulated ischemia and protection against gap junctional uncoupling. Cell Commun Adhes. 2007 Sep-Oct; 14(5):239-49. PMID: 18163233.
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  65. Holt DB, Lublin DM, Phelan DL, Boslaugh SE, Gandhi SK, Huddleston CB, Saffitz JE, Canter CE. Mortality and morbidity in pre-sensitized pediatric heart transplant recipients with a positive donor crossmatch utilizing peri-operative plasmapheresis and cytolytic therapy. J Heart Lung Transplant. 2007 Sep; 26(9):876-82. PMID: 17845925.
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  66. Saffitz JE, Hames KY, Kanno S. Remodeling of gap junctions in ischemic and nonischemic forms of heart disease. J Membr Biol. 2007 Aug; 218(1-3):65-71. PMID: 17585361.
    View in: PubMed
  67. Jeyaraj D, Wilson LD, Zhong J, Flask C, Saffitz JE, Deschênes I, Yu X, Rosenbaum DS. Mechanoelectrical feedback as novel mechanism of cardiac electrical remodeling. Circulation. 2007 Jun 26; 115(25):3145-55. PMID: 17562957.
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  68. Hund TJ, Lerner DL, Yamada KA, Schuessler RB, Saffitz JE. Protein kinase Cepsilon mediates salutary effects on electrical coupling induced by ischemic preconditioning. Heart Rhythm. 2007 Sep; 4(9):1183-93. PMID: 17765619; PMCID: PMC2711555.
    View in: PubMed, PubMed Central
  69. Oxford EM, Everitt M, Coombs W, Fox PR, Kraus M, Gelzer AR, Saffitz J, Taffet SM, Moïse NS, Delmar M. Molecular composition of the intercalated disc in a spontaneous canine animal model of arrhythmogenic right ventricular dysplasia/cardiomyopathy. Heart Rhythm. 2007 Sep; 4(9):1196-205. PMID: 17765621; PMCID: PMC2080779.
    View in: PubMed, PubMed Central
  70. Laing JG, Saffitz JE, Steinberg TH, Yamada KA. Diminished zonula occludens-1 expression in the failing human heart. Cardiovasc Pathol. 2007 May-Jun; 16(3):159-64. PMID: 17502245.
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  71. Mancuso DJ, Han X, Jenkins CM, Lehman JJ, Sambandam N, Sims HF, Yang J, Yan W, Yang K, Green K, Abendschein DR, Saffitz JE, Gross RW. Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem. 2007 Mar 23; 282(12):9216-27. PMID: 17213206.
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  72. Beauchamp P, Yamada KA, Baertschi AJ, Green K, Kanter EM, Saffitz JE, Kléber AG. Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes. Circ Res. 2006 Nov 24; 99(11):1216-24. PMID: 17053190.
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  73. Yang Z, Bowles NE, Scherer SE, Taylor MD, Kearney DL, Ge S, Nadvoretskiy VV, DeFreitas G, Carabello B, Brandon LI, Godsel LM, Green KJ, Saffitz JE, Li H, Danieli GA, Calkins H, Marcus F, Towbin JA. Desmosomal dysfunction due to mutations in desmoplakin causes arrhythmogenic right ventricular dysplasia/cardiomyopathy. Circ Res. 2006 Sep 15; 99(6):646-55. PMID: 16917092.
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  74. Saffitz JE. Connexins, conduction, and atrial fibrillation. N Engl J Med. 2006 Jun 22; 354(25):2712-4. PMID: 16790707.
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  75. Saffitz JE. Adhesion molecules: why they are important to the electrophysiologist. J Cardiovasc Electrophysiol. 2006 Feb; 17(2):225-9. PMID: 16533266.
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  78. Zheng J, El Naqa I, Rowold FE, Pilgram TK, Woodard PK, Saffitz JE, Tang D. Quantitative assessment of coronary artery plaque vulnerability by high-resolution magnetic resonance imaging and computational biomechanics: a pilot study ex vivo. Magn Reson Med. 2005 Dec; 54(6):1360-8. PMID: 16265643; PMCID: PMC1474004.
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  79. Tang D, Yang C, Zheng J, Woodard PK, Saffitz JE, Petruccelli JD, Sicard GA, Yuan C. Local maximal stress hypothesis and computational plaque vulnerability index for atherosclerotic plaque assessment. Ann Biomed Eng. 2005 Dec; 33(12):1789-801. PMID: 16389527; PMCID: PMC1474005.
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  80. Tang D, Yang C, Zheng J, Woodard PK, Saffitz JE, Sicard GA, Pilgram TK, Yuan C. Quantifying effects of plaque structure and material properties on stress distributions in human atherosclerotic plaques using 3D FSI models. J Biomech Eng. 2005 Dec; 127(7):1185-94. PMID: 16502661; PMCID: PMC1474006.
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  81. Minami E, Laflamme MA, Saffitz JE, Murry CE. Extracardiac progenitor cells repopulate most major cell types in the transplanted human heart. Circulation. 2005 Nov 08; 112(19):2951-8. PMID: 16275883.
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  82. Reynolds DW, Chen PS, Deal BJ, Donahue JK, Ellenbogen KA, Epstein AE, Friedman PA, Hammill SC, Hohnloser SH, Kanter RJ, Lindsay BD, Natale A, Saffitz J, Stevenson WG. Highlights of Heart Rhythm 2005, the Annual Scientific Sessions of the Heart Rhythm Society, May 4-7, 2005, New Orleans, Louisiana. Heart Rhythm. 2005 Sep; 2(9):1025-33. PMID: 16171766.
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  83. Gard JJ, Yamada K, Green KG, Eloff BC, Rosenbaum DS, Wang X, Robbins J, Schuessler RB, Yamada KA, Saffitz JE. Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy. Cardiovasc Res. 2005 Aug 15; 67(3):539-47. PMID: 15913582.
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  84. Yamada K, Green KG, Samarel AM, Saffitz JE. Distinct pathways regulate expression of cardiac electrical and mechanical junction proteins in response to stretch. Circ Res. 2005 Aug 19; 97(4):346-53. PMID: 16037569.
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  85. Saffitz JE. The pathology of sudden cardiac death in patients with ischemic heart disease--arrhythmology for anatomic pathologists. Cardiovasc Pathol. 2005 Jul-Aug; 14(4):195-203. PMID: 16009318.
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  86. Hund TJ, Saffitz JE. Is CaMKII a therapeutic target for ventricular rate control? Heart Rhythm. 2005 Jun; 2(6):641-2. PMID: 15922274.
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  87. Saffitz JE. Dependence of electrical coupling on mechanical coupling in cardiac myocytes: insights gained from cardiomyopathies caused by defects in cell-cell connections. Ann N Y Acad Sci. 2005 Jun; 1047:336-44. PMID: 16093509.
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  88. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP. PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biol. 2005 Apr; 3(4):e101. PMID: 15760270; PMCID: PMC1064854.
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  89. Shanker AJ, Yamada K, Green KG, Yamada KA, Saffitz JE. Matrix-protein-specific regulation of Cx43 expression in cardiac myocytes subjected to mechanical load. Circ Res. 2005 Mar 18; 96(5):558-66. PMID: 15705967.
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  90. Saffitz JE, Schuessler RB. Altered atrial structure begets atrial fibrillation, but how? J Cardiovasc Electrophysiol. 2004 Oct; 15(10):1175-6. PMID: 15485443.
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  91. Tang D, Yang C, Zheng J, Woodard PK, Sicard GA, Saffitz JE, Yuan C. 3D MRI-based multicomponent FSI models for atherosclerotic plaques. Ann Biomed Eng. 2004 Jul; 32(7):947-60. PMID: 15298432.
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  92. Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A. 2004 Jul 06; 101(27):10132-6. PMID: 15220483; PMCID: PMC454177.
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  93. Beauchamp P, Choby C, Desplantez T, de Peyer K, Green K, Yamada KA, Weingart R, Saffitz JE, Kléber AG. Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ Res. 2004 Jul 23; 95(2):170-8. PMID: 15192022.
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  94. Yamada KA, Kanter EM, Green KG, Saffitz JE. Transmural distribution of connexins in rodent hearts. J Cardiovasc Electrophysiol. 2004 Jun; 15(6):710-5. PMID: 15175068.
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  95. Kaplan SR, Gard JJ, Protonotarios N, Tsatsopoulou A, Spiliopoulou C, Anastasakis A, Squarcioni CP, McKenna WJ, Thiene G, Basso C, Brousse N, Fontaine G, Saffitz JE. Remodeling of myocyte gap junctions in arrhythmogenic right ventricular cardiomyopathy due to a deletion in plakoglobin (Naxos disease). Heart Rhythm. 2004 May; 1(1):3-11. PMID: 15851108.
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  96. McOmber D, Ibrahim J, Lublin DM, Saffitz JE, Ong-Simon C, Mendeloff EN, Huddleston CB, Canter CE. Non-ischemic left ventricular dysfunction after pediatric cardiac transplantation: treatment with plasmapheresis and OKT3. J Heart Lung Transplant. 2004 May; 23(5):552-7. PMID: 15135370.
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  97. Betsuyaku T, Kanno S, Lerner DL, Schuessler RB, Saffitz JE, Yamada KA. Spontaneous and inducible ventricular arrhythmias after myocardial infarction in mice. Cardiovasc Pathol. 2004 May-Jun; 13(3):156-64. PMID: 15081472.
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  98. Saffitz JE, Kléber AG. Effects of mechanical forces and mediators of hypertrophy on remodeling of gap junctions in the heart. Circ Res. 2004 Mar 19; 94(5):585-91. PMID: 15031271.
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  99. Petrich BG, Eloff BC, Lerner DL, Kovacs A, Saffitz JE, Rosenbaum DS, Wang Y. Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. J Biol Chem. 2004 Apr 09; 279(15):15330-8. PMID: 14742426.
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  100. Russell LK, Mansfield CM, Lehman JJ, Kovacs A, Courtois M, Saffitz JE, Medeiros DM, Valencik ML, McDonald JA, Kelly DP. Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner. Circ Res. 2004 Mar 05; 94(4):525-33. PMID: 14726475.
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  102. Yamada KA, Rogers JG, Sundset R, Steinberg TH, Saffitz J. Up-regulation of connexin45 in heart failure. J Cardiovasc Electrophysiol. 2003 Nov; 14(11):1205-12. PMID: 14678136.
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  103. Thomas SP, Kucera JP, Bircher-Lehmann L, Rudy Y, Saffitz JE, Kléber AG. Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43. Circ Res. 2003 Jun 13; 92(11):1209-16. PMID: 12730095; PMCID: PMC2242733.
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  105. Mancuso DJ, Abendschein DR, Jenkins CM, Han X, Saffitz JE, Schuessler RB, Gross RW. Cardiac ischemia activates calcium-independent phospholipase A2beta, precipitating ventricular tachyarrhythmias in transgenic mice: rescue of the lethal electrophysiologic phenotype by mechanism-based inhibition. J Biol Chem. 2003 Jun 20; 278(25):22231-6. PMID: 12719436.
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  106. Chen Z, Fitzgerald RL, Saffitz JE, Semenkovich CF, Schonfeld G. Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arterioscler Thromb Vasc Biol. 2003 Apr 01; 23(4):668-74. PMID: 12615667.
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  108. Petrich BG, Gong X, Lerner DL, Wang X, Brown JH, Saffitz JE, Wang Y. c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. Circ Res. 2002 Oct 04; 91(7):640-7. PMID: 12364393.
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  109. Kanno S, Lerner DL, Schuessler RB, Betsuyaku T, Yamada KA, Saffitz JE, Kovacs A. Echocardiographic evaluation of ventricular remodeling in a mouse model of myocardial infarction. J Am Soc Echocardiogr. 2002 Jun; 15(6):601-9. PMID: 12050601.
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  111. Laflamme MA, Myerson D, Saffitz JE, Murry CE. Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ Res. 2002 Apr 05; 90(6):634-40. PMID: 11934829.
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  113. Saffitz JE, Kaplan SR. Pathologic basis of conduction disturbances: the challenge to move beyond microscopic anatomy. J Cardiovasc Electrophysiol. 2002 Mar; 13(3):265-6. PMID: 11942595.
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  115. Liao P, Georgakopoulos D, Kovacs A, Zheng M, Lerner D, Pu H, Saffitz J, Chien K, Xiao RP, Kass DA, Wang Y. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12283-8. PMID: 11593045; PMCID: PMC59806.
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  116. Eloff BC, Lerner DL, Yamada KA, Schuessler RB, Saffitz JE, Rosenbaum DS. High resolution optical mapping reveals conduction slowing in connexin43 deficient mice. Cardiovasc Res. 2001 Sep; 51(4):681-90. PMID: 11530101.
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  119. Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, Saffitz JE, Schaffer JE. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001 Apr; 107(7):813-22. PMID: 11285300; PMCID: PMC199569.
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  120. Wu J, Schuessler RB, Rodefeld MD, Saffitz JE, Boineau JP. Morphological and membrane characteristics of spider and spindle cells isolated from rabbit sinus node. Am J Physiol Heart Circ Physiol. 2001 Mar; 280(3):H1232-40. PMID: 11179068.
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  121. Lerner DL, Chapman Q, Green KG, Saffitz JE. Reversible down-regulation of connexin43 expression in acute cardiac allograft rejection. J Heart Lung Transplant. 2001 Jan; 20(1):93-7. PMID: 11166617.
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  122. Saffitz JE, Schuessler RB. Connexin-40, bundle-branch block, and propagation at the Purkinje-myocyte junction. Circ Res. 2000 Nov 10; 87(10):835-6. PMID: 11073876.
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  124. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 2000 Oct; 106(7):847-56. PMID: 11018072; PMCID: PMC517815.
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  125. Thomas SP, Bircher-Lehmann L, Thomas SA, Zhuang J, Saffitz JE, Kléber AG. Synthetic strands of neonatal mouse cardiac myocytes: structural and electrophysiological properties. Circ Res. 2000 Sep 15; 87(6):467-73. PMID: 10988238.
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  126. Zhuang J, Yamada KA, Saffitz JE, Kléber AG. Pulsatile stretch remodels cell-to-cell communication in cultured myocytes. Circ Res. 2000 Aug 18; 87(4):316-22. PMID: 10948066.
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  128. Saffitz JE, Laing JG, Yamada KA. Connexin expression and turnover : implications for cardiac excitability. Circ Res. 2000 Apr 14; 86(7):723-8. PMID: 10764404.
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  129. Saffitz JE. Regulation of intercellular coupling in acute and chronic heart disease. Braz J Med Biol Res. 2000 Apr; 33(4):407-13. PMID: 10775305.
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  134. Antzelevitch C, Shimizu W, Yan GX, Sicouri S, Weissenburger J, Nesterenko VV, Burashnikov A, Di Diego J, Saffitz J, Thomas GP. The M cell: its contribution to the ECG and to normal and abnormal electrical function of the heart. J Cardiovasc Electrophysiol. 1999 Aug; 10(8):1124-52. PMID: 10466495.
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  135. Kavanagh KM, Guerrero PA, Jugdutt BI, Witkowski FX, Saffitz JE. Electrophysiologic properties and ventricular fibrillation in normal and myopathic hearts. Can J Physiol Pharmacol. 1999 Jul; 77(7):510-9. PMID: 10535711.
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  136. Chen Z, Saffitz JE, Latour MA, Schonfeld G. Truncated apo B-70.5-containing lipoproteins bind to megalin but not the LDL receptor. J Clin Invest. 1999 May 15; 103(10):1419-30. PMID: 10330424; PMCID: PMC408451.
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  138. Saffitz JE. Toward a clearer understanding of the link between viral infection of the heart and dilated cardiomyopathy. Adv Anat Pathol. 1999 May; 6(3):154-60. PMID: 10342013.
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  139. Kwong KF, Schuessler RB, Kanellopoulos GK, Saffitz JE, Sundt TM. Nontransmural laser treatment incompletely denervates canine myocardium. Circulation. 1998 Nov 10; 98(19 Suppl):II67-71; discussion II71-2. PMID: 9852883.
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  140. Beardslee MA, Laing JG, Beyer EC, Saffitz JE. Rapid turnover of connexin43 in the adult rat heart. Circ Res. 1998 Sep 21; 83(6):629-35. PMID: 9742058.
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  141. Djouadi F, Weinheimer CJ, Saffitz JE, Pitchford C, Bastin J, Gonzalez FJ, Kelly DP. A gender-related defect in lipid metabolism and glucose homeostasis in peroxisome proliferator- activated receptor alpha- deficient mice. J Clin Invest. 1998 Sep 15; 102(6):1083-91. PMID: 9739042; PMCID: PMC509091.
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  142. Dodge SM, Beardslee MA, Darrow BJ, Green KG, Beyer EC, Saffitz JE. Effects of angiotensin II on expression of the gap junction channel protein connexin43 in neonatal rat ventricular myocytes. J Am Coll Cardiol. 1998 Sep; 32(3):800-7. PMID: 9741530.
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  143. Laing JG, Tadros PN, Green K, Saffitz JE, Beyer EC. Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes. Cardiovasc Res. 1998 Jun; 38(3):711-8. PMID: 9747439.
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  144. Thomas SA, Schuessler RB, Saffitz JE. Connexins, conduction, and atrial fibrillation. J Cardiovasc Electrophysiol. 1998 Jun; 9(6):608-11. PMID: 9654225.
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  145. Kwong KF, Schuessler RB, Green KG, Laing JG, Beyer EC, Boineau JP, Saffitz JE. Differential expression of gap junction proteins in the canine sinus node. Circ Res. 1998 Mar 23; 82(5):604-12. PMID: 9529165.
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  146. Saffitz JE, Yamada KA. Do alterations in intercellular coupling play a role in cardiac contractile dysfunction? Circulation. 1998 Feb 24; 97(7):630-2. PMID: 9495295.
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  148. Weck KE, Dal Canto AJ, Gould JD, O'Guin AK, Roth KA, Saffitz JE, Speck SH, Virgin HW. Murine gamma-herpesvirus 68 causes severe large-vessel arteritis in mice lacking interferon-gamma responsiveness: a new model for virus-induced vascular disease. Nat Med. 1997 Dec; 3(12):1346-53. PMID: 9396604.
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  149. Kwong KF, Kanellopoulos GK, Nickols JC, Pogwizd SM, Saffitz JE, Schuessler RB, Sundt TM. Transmyocardial laser treatment denervates canine myocardium. J Thorac Cardiovasc Surg. 1997 Dec; 114(6):883-9; discussion 889-90. PMID: 9434682.
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  151. Guerrero PA, Schuessler RB, Davis LM, Beyer EC, Johnson CM, Yamada KA, Saffitz JE. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J Clin Invest. 1997 Apr 15; 99(8):1991-8. PMID: 9109444; PMCID: PMC508024.
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  152. Ishikawa Y, Saffitz JE, Mealman TL, Grace AM, Roberts R. Reversible myocardial ischemic injury is not associated with increased creatine kinase activity in plasma. Clin Chem. 1997 Mar; 43(3):467-75. PMID: 9068590.
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  153. Saffitz JE. Gap junctions: functional effects of molecular structure and tissue distribution. Adv Exp Med Biol. 1997; 430:291-301. PMID: 9330738.
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  154. Tsai CC, Saffitz JE, Billadello JJ. Expression of the Gs protein alpha-subunit disrupts the normal program of differentiation in cultured murine myogenic cells. J Clin Invest. 1997 Jan 01; 99(1):67-76. PMID: 9011578; PMCID: PMC507769.
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  155. Nash JA, Hammond HK, Saffitz JE. Subcellular compartmentalization of Gs alpha in cardiac myocytes and its redistribution in heart failure. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2209-17. PMID: 8997276.
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  156. Rodefeld MD, Beau SL, Schuessler RB, Boineau JP, Saffitz JE. Beta-adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node: identification of a high beta 2-adrenergic receptor density. J Cardiovasc Electrophysiol. 1996 Nov; 7(11):1039-49. PMID: 8930735.
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  157. Darrow BJ, Fast VG, Kléber AG, Beyer EC, Saffitz JE. Functional and structural assessment of intercellular communication. Increased conduction velocity and enhanced connexin expression in dibutyryl cAMP-treated cultured cardiac myocytes. Circ Res. 1996 Aug; 79(2):174-83. PMID: 8755993.
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  158. Fast VG, Darrow BJ, Saffitz JE, Kléber AG. Anisotropic activation spread in heart cell monolayers assessed by high-resolution optical mapping. Role of tissue discontinuities. Circ Res. 1996 Jul; 79(1):115-27. PMID: 8925559.
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  159. Santos-Ocampo SD, Sekarski TJ, Saffitz JE, Bridges ND, Huddleston CB, Spray TL, Canter CE. Echocardiographic characteristics of biopsy-proven cellular rejection in infant heart transplant recipients. J Heart Lung Transplant. 1996 Jan; 15(1 Pt 1):25-34. PMID: 8820080.
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  160. Diebold RJ, Eis MJ, Yin M, Ormsby I, Boivin GP, Darrow BJ, Saffitz JE, Doetschman T. Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12215-9. PMID: 8618872; PMCID: PMC40327.
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  161. Soudais C, Bielinska M, Heikinheimo M, MacArthur CA, Narita N, Saffitz JE, Simon MC, Leiden JM, Wilson DB. Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro. Development. 1995 Nov; 121(11):3877-88. PMID: 8582296.
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  162. Balzer DT, Moorhead S, Saffitz JE, Huddleston CB, Spray TL, Canter CE. Utility of surveillance biopsies in infant heart transplant recipients. J Heart Lung Transplant. 1995 Nov-Dec; 14(6 Pt 1):1095-101. PMID: 8719456.
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  163. Beau SL, Hand DE, Schuessler RB, Bromberg BI, Kwon B, Boineau JP, Saffitz JE. Relative densities of muscarinic cholinergic and beta-adrenergic receptors in the canine sinoatrial node and their relation to sites of pacemaker activity. Circ Res. 1995 Nov; 77(5):957-63. PMID: 7554150.
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  164. Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JE. Gap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol. 1995 Oct; 6(10 Pt 1):813-22. PMID: 8542077.
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  165. Ohnishi Y, Butterfield MC, Saffitz JE, Sobel BE, Corr PB, Goldstein JA. Deleterious effects of a systemic lytic state on reperfused myocardium. Minimization of reperfusion injury and enhanced recovery of myocardial function by direct angioplasty. Circulation. 1995 Aug 01; 92(3):500-10. PMID: 7634465.
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  166. Kanter HL, Beyer EC, Saffitz JE. Structural and molecular determinants of intercellular coupling in cardiac myocytes. Microsc Res Tech. 1995 Aug 01; 31(5):357-63. PMID: 8534897.
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  167. Recchia D, Abendschein DR, Saffitz JE, Wickline SA. The biologic behavior of balloon hyperinflation-induced arterial lesions in hypercholesterolemic pigs depends on the presence of foam cells. Arterioscler Thromb Vasc Biol. 1995 Jul; 15(7):924-9. PMID: 7541293.
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  169. Warshawsky I, Bu G, Mast A, Saffitz JE, Broze GJ, Schwartz AL. The carboxy terminus of tissue factor pathway inhibitor is required for interacting with hepatoma cells in vitro and in vivo. J Clin Invest. 1995 Apr; 95(4):1773-81. PMID: 7706485; PMCID: PMC295702.
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  170. Beyer EC, Davis LM, Saffitz JE, Veenstra RD. Cardiac intercellular communication: consequences of connexin distribution and diversity. Braz J Med Biol Res. 1995 Apr; 28(4):415-25. PMID: 8520538.
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  171. Darrow BJ, Laing JG, Lampe PD, Saffitz JE, Beyer EC. Expression of multiple connexins in cultured neonatal rat ventricular myocytes. Circ Res. 1995 Mar; 76(3):381-7. PMID: 7859384.
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  172. Davis LM, Saffitz JE, Beyer EC. Modulation of connexin43 expression: effects on cellular coupling. J Cardiovasc Electrophysiol. 1995 Feb; 6(2):103-14. PMID: 7780626.
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  173. Grant JW, Canter CE, Spray TL, Landt Y, Saffitz JE, Ladenson JH, Jaffe AS. Elevated donor cardiac troponin I. A marker of acute graft failure in infant heart recipients. Circulation. 1994 Dec; 90(6):2618-21. PMID: 7994800.
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  174. Chen SC, Davis LM, Westphale EM, Beyer EC, Saffitz JE. Expression of multiple gap junction proteins in human fetal and infant hearts. Pediatr Res. 1994 Nov; 36(5):561-6. PMID: 7877871.
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  175. Davis LM, Kanter HL, Beyer EC, Saffitz JE. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J Am Coll Cardiol. 1994 Oct; 24(4):1124-32. PMID: 7930207.
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  176. Laster SB, Ohnishi Y, Saffitz JE, Goldstein JA. Effects of reperfusion on ischemic right ventricular dysfunction. Disparate mechanisms of benefit related to duration of ischemia. Circulation. 1994 Sep; 90(3):1398-409. PMID: 8087950.
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  177. York JD, Saffitz JE, Majerus PW. Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis. J Biol Chem. 1994 Aug 05; 269(31):19992-9. PMID: 8051083.
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  178. Kanter HL, Saffitz JE, Beyer EC. Molecular cloning of two human cardiac gap junction proteins, connexin40 and connexin45. J Mol Cell Cardiol. 1994 Jul; 26(7):861-8. PMID: 7966354.
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  179. Saffitz JE, Kanter HL, Green KG, Tolley TK, Beyer EC. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res. 1994 Jun; 74(6):1065-70. PMID: 8187276.
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  180. Saffitz JE. Myocyte interconnections at gap junctions and the development of anatomic substrates of ventricular arrhythmia's. Cardiovasc Pathol. 1994 Apr-Jun; 3(2):87-91. PMID: 25990853.
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  181. Beau SL, Saffitz JE. Transmural heterogeneity of norepinephrine uptake in failing human hearts. J Am Coll Cardiol. 1994 Mar 01; 23(3):579-85. PMID: 8113537.
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  182. Saffitz JE, Nash JA, Green KG, Luke RA, Ransnas LA, Insel PA. Immunoelectron microscopic identification of cytoplasmic and nuclear Gs alpha in S49 lymphoma cells. FASEB J. 1994 Feb; 8(2):252-8. PMID: 8119495.
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  183. Creswell LL, Rosenbloom M, Pirolo JS, Saffitz JE, Cox JL. Potential ablation of accessory atrioventricular pathways: injection of alcohol into the atrioventricular groove. Ann Thorac Surg. 1994 Jan; 57(1):203-7. PMID: 8279892.
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  184. Canter CE, Moorhead S, Saffitz JE, Huddleston CB, Spray TL. Steroid withdrawal in the pediatric heart transplant recipient initially treated with triple immunosuppression. J Heart Lung Transplant. 1994 Jan-Feb; 13(1 Pt 1):74-9; discussion 79-80. PMID: 8167131.
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  185. Beau SL, Tolley TK, Saffitz JE. Heterogeneous transmural distribution of beta-adrenergic receptor subtypes in failing human hearts. Circulation. 1993 Dec; 88(6):2501-9. PMID: 7902783.
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  186. Saffitz JE, Stahl DJ, Sundt TM, Wareing TH, Kouchoukos NT. Disseminated intravascular coagulation after administration of aprotinin in combination with deep hypothermic circulatory arrest. Am J Cardiol. 1993 Nov 01; 72(14):1080-2. PMID: 7692717.
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  187. Woodle ES, Phelan DL, Saffitz JE, Mohanakumar T, Shenoy S, Pasque M. FK506--reversal of humorally mediated cardiac allograft rejection in the presence of preformed anti-class I antibody. Transplantation. 1993 Nov; 56(5):1271-5. PMID: 7504346.
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  188. Balzer D, Moorhead S, Saffitz JE, Sekarski DR, Canter CE. Pediatric endomyocardial biopsy performed solely with echocardiographic guidance. J Am Soc Echocardiogr. 1993 Sep-Oct; 6(5):510-5. PMID: 8260169.
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  189. Kanter HL, Laing JG, Beyer EC, Green KG, Saffitz JE. Multiple connexins colocalize in canine ventricular myocyte gap junctions. Circ Res. 1993 Aug; 73(2):344-50. PMID: 8392450.
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  190. McHowat J, Yamada KA, Saffitz JE, Corr PB. Subcellular distribution of endogenous long chain acylcarnitines during hypoxia in adult canine myocytes. Cardiovasc Res. 1993 Jul; 27(7):1237-43. PMID: 8252583.
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  191. Sundt TM, Kouchoukos NT, Saffitz JE, Murphy SF, Wareing TH, Stahl DJ. Renal dysfunction and intravascular coagulation with aprotinin and hypothermic circulatory arrest. Ann Thorac Surg. 1993 Jun; 55(6):1418-24. PMID: 7685587.
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  192. Kanter HL, Laing JG, Beau SL, Beyer EC, Saffitz JE. Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle. Circ Res. 1993 May; 72(5):1124-31. PMID: 8386597.
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  193. Rooney IA, Atkinson JP, Krul ES, Schonfeld G, Polakoski K, Saffitz JE, Morgan BP. Physiologic relevance of the membrane attack complex inhibitory protein CD59 in human seminal plasma: CD59 is present on extracellular organelles (prostasomes), binds cell membranes, and inhibits complement-mediated lysis. J Exp Med. 1993 May 01; 177(5):1409-20. PMID: 7683035; PMCID: PMC2191001.
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  194. Saffitz JE, Corr PB, Sobel BE. Arrhythmogenesis and ventricular dysfunction after myocardial infarction. Is anomalous cellular coupling the elusive link? Circulation. 1993 May; 87(5):1742-5. PMID: 8491027.
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  195. Canter CE, Saffitz JE, Moorhead S, Gutierrez FR, Bolman RM, Spray TL. Early results after pediatric cardiac transplantation with triple immunosuppression therapy. Am J Cardiol. 1993 Apr 15; 71(11):971-5. PMID: 8465791.
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  196. Saffitz JE, Beau SL. Noninvasive quantification of myocardial beta-adrenergic receptors. A first step. Circulation. 1993 Apr; 87(4):1412-4. PMID: 8096442.
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  197. Wu J, McHowat J, Saffitz JE, Yamada KA, Corr PB. Inhibition of gap junctional conductance by long-chain acylcarnitines and their preferential accumulation in junctional sarcolemma during hypoxia. Circ Res. 1993 Apr; 72(4):879-89. PMID: 8443874.
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  198. Pogwizd SM, Hoyt RH, Saffitz JE, Corr PB, Cox JL, Cain ME. Reentrant and focal mechanisms underlying ventricular tachycardia in the human heart. Circulation. 1992 Dec; 86(6):1872-87. PMID: 1451259.
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  199. Fujii S, Sawa H, Saffitz JE, Lucore CL, Sobel BE. Induction of endothelial cell expression of the plasminogen activator inhibitor type 1 gene by thrombosis in vivo. Circulation. 1992 Dec; 86(6):2000-10. PMID: 1451272.
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  200. Saffitz JE, Liggett SB. Subcellular distribution of beta 2-adrenergic receptors delineated with quantitative ultrastructural autoradiography of radioligand binding sites. Circ Res. 1992 Jun; 70(6):1320-5. PMID: 1315641.
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  201. Martin WH, Korte E, Tolley TK, Saffitz JE. Skeletal muscle beta-adrenoceptor distribution and responses to isoproterenol in hyperthyroidism. Am J Physiol. 1992 Apr; 262(4 Pt 1):E504-10. PMID: 1314497.
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  202. Saffitz JE, Hoyt RH, Luke RA, Lee Kanter H, Beyer EC. Cardiac myocyte interconnections at gap junctions Role in normal and abnormal electrical conduction. Trends Cardiovasc Med. 1992 Mar-Apr; 2(2):56-60. PMID: 21239275.
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  203. Kanter HL, Saffitz JE, Beyer EC. Cardiac myocytes express multiple gap junction proteins. Circ Res. 1992 Feb; 70(2):438-44. PMID: 1310450.
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  204. Roysam B, Maffitt DR, Miller MI, Saffitz JE, Thomas LJ. A personal computer based implementation of the maximum-likelihood method of analysis of electron microscope autoradiographs. Microsc Res Tech. 1992 Jan 01; 20(1):73-86. PMID: 1611151.
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  205. Saffitz JE. Toward a unified concept of vascular smooth muscle response to injury. Am J Clin Pathol. 1992 Jan; 97(1):1-3. PMID: 1728848.
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  206. Wong EC, Saffitz JE, McDonald JM. Association of calmodulin with isolated nuclei from rat hepatocytes. Biochem Biophys Res Commun. 1991 Dec 31; 181(3):1548-56. PMID: 1764103.
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  207. Martin WH, Spina RJ, Korte E, Yarasheski KE, Angelopoulos TJ, Nemeth PM, Saffitz JE. Mechanisms of impaired exercise capacity in short duration experimental hyperthyroidism. J Clin Invest. 1991 Dec; 88(6):2047-53. PMID: 1752962; PMCID: PMC295798.
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  208. Canter CE, Appleton RS, Saffitz JE, Bologna S, Miller L, Pennington DG, Spray TL. Surveillance for rejection by echocardiographically guided endomyocardial biopsy in the infant heart transplant recipient. Circulation. 1991 Nov; 84(5 Suppl):III310-5. PMID: 1934425.
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  209. Ford DA, Hazen SL, Saffitz JE, Gross RW. The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia. J Clin Invest. 1991 Jul; 88(1):331-5. PMID: 2056126; PMCID: PMC296037.
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  210. Luke RA, Saffitz JE. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest. 1991 May; 87(5):1594-602. PMID: 2022731; PMCID: PMC295242.
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  211. Wareing TH, Saffitz JE, Kouchoukos NT. Use of single internal mammary artery grafts in older patients. Circulation. 1990 Nov; 82(5 Suppl):IV224-8. PMID: 2225408.
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  212. Martin WH, Tolley TK, Saffitz JE. Autoradiographic delineation of skeletal muscle alpha 1-adrenergic receptor distribution. Am J Physiol. 1990 Nov; 259(5 Pt 2):H1402-8. PMID: 1978576.
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  213. Bolman R, Saffitz J. Early postoperative care of the cardiac transplantation patient: routine considerations and immunosuppressive therapy. Prog Cardiovasc Dis. 1990 Nov-Dec; 33(3):137-48. PMID: 2236562.
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  214. Miyazaki Y, Gross RW, Sobel BE, Saffitz JE. Selective turnover of sarcolemmal phospholipids with lethal cardiac myocyte injury. Am J Physiol. 1990 Aug; 259(2 Pt 1):C325-31. PMID: 2382705.
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  215. Hoyt RH, Cohen ML, Corr PB, Saffitz JE. Alterations of intercellular junctions induced by hypoxia in canine myocardium. Am J Physiol. 1990 May; 258(5 Pt 2):H1439-48. PMID: 2337178.
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  216. Haskel EJ, Adams SP, Feigen LP, Saffitz JE, Gorczynski RJ, Sobel BE, Abendschein DR. Prevention of reoccluding platelet-rich thrombi in canine femoral arteries with a novel peptide antagonist of platelet glycoprotein IIb/IIIa receptors. Circulation. 1989 Dec; 80(6):1775-82. PMID: 2513145.
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  217. Luke RA, Beyer EC, Hoyt RH, Saffitz JE. Quantitative analysis of intercellular connections by immunohistochemistry of the cardiac gap junction protein connexin43. Circ Res. 1989 Nov; 65(5):1450-7. PMID: 2478314.
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  218. Martin WH, Coggan AR, Spina RJ, Saffitz JE. Effects of fiber type and training on beta-adrenoceptor density in human skeletal muscle. Am J Physiol. 1989 Nov; 257(5 Pt 1):E736-42. PMID: 2556938.
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  219. Marshall WG, Barzilai B, Kouchoukos NT, Saffitz J. Intraoperative ultrasonic imaging of the ascending aorta. Ann Thorac Surg. 1989 Sep; 48(3):339-44. PMID: 2673086.
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  220. Barzilai B, Marshall WG, Saffitz JE, Kouchoukos N. Avoidance of embolic complications by ultrasonic characterization of the ascending aorta. Circulation. 1989 Sep; 80(3 Pt 1):I275-9. PMID: 2670329.
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  221. Cohen ML, Hoyt RH, Saffitz JE, Corr PB. A high density in vitro extracellular electrode array: description and implementation. Am J Physiol. 1989 Aug; 257(2 Pt 2):H681-9. PMID: 2764148.
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  222. Dunkel CG, Saffitz JE, Evers AS. fMet-Leu-Phe receptor expression by an interstitial cell in rabbit right atrium following left ventricular myocardial infarction. Circ Res. 1989 Jul; 65(1):215-23. PMID: 2736736.
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  223. Freed MS, Spaethe SM, Lefkowith JB, Saffitz JE, Needleman P. Essential fatty acid deficiency inhibits early but not late leukocyte infiltration in rabbit myocardial infarcts. Prostaglandins. 1989 Jul; 38(1):33-44. PMID: 2546188.
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  224. Saffitz JE. Distribution of alpha 1-adrenergic receptors in myocytic regions and vasculature of feline myocardium. Am J Physiol. 1989 Jul; 257(1 Pt 2):H162-9. PMID: 2546448.
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  225. Murphree SS, Saffitz JE. Distribution of beta-adrenergic receptors in failing human myocardium. Implications for mechanisms of down-regulation. Circulation. 1989 Jun; 79(6):1214-25. PMID: 2566394.
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  226. Martin WH, Murphree SS, Saffitz JE. Beta-adrenergic receptor distribution among muscle fiber types and resistance arterioles of white, red, and intermediate skeletal muscle. Circ Res. 1989 Jun; 64(6):1096-105. PMID: 2541942.
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  227. Corr PB, Creer MH, Yamada KA, Saffitz JE, Sobel BE. Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation. J Clin Invest. 1989 Mar; 83(3):927-36. PMID: 2921326; PMCID: PMC303768.
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  228. Rosenbloom M, Laschinger JC, Saffitz JE, Cox JL, Bolman RM. Noninvasive detection of cardiac allograft rejection by analysis of the unipolar peak-to-peak amplitude of intramyocardial electrograms. Ann Thorac Surg. 1989 Mar; 47(3):407-11. PMID: 2649032.
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  229. Hoyt RH, Cohen ML, Saffitz JE. Distribution and three-dimensional structure of intercellular junctions in canine myocardium. Circ Res. 1989 Mar; 64(3):563-74. PMID: 2645060.
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  230. Bolman RM, Cox JL, Marshall W, Kouchoukos N, Spray TL, Cance C, Genton RE, Saffitz J. Circulatory support with a centrifugal pump as a bridge to cardiac transplantation. Ann Thorac Surg. 1989 Jan; 47(1):108-12. PMID: 2643398.
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  231. Freed MS, Needleman P, Dunkel CG, Saffitz JE, Evers AS. Role of invading leukocytes in enhanced atrial eicosanoid production following rabbit left ventricular myocardial infarction. J Clin Invest. 1989 Jan; 83(1):205-12. PMID: 2492036; PMCID: PMC303663.
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  232. Rosenbloom M, Eisen HJ, Laschinger J, Saffitz JE, Sobel BE, Bergmann SR, Bolman RM. Noninvasive assessment of treatment of cardiac allograft rejection with indium-111-labeled lymphocytes. Transplantation. 1988 Sep; 46(3):341-6. PMID: 3047922.
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  233. Eisen HJ, Rosenbloom M, Laschinger JC, Saffitz JE, Cox JL, Sobel BE, Bolman RM, Bergmann SR. Detection of rejection of canine orthotopic cardiac allografts with indium-111 lymphocytes and gamma scintigraphy. J Nucl Med. 1988 Jul; 29(7):1223-9. PMID: 3292723.
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  234. Murphree SS, Saffitz JE. Delineation of the distribution of beta-adrenergic receptor subtypes in canine myocardium. Circ Res. 1988 Jul; 63(1):117-25. PMID: 2838202.
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  235. Barzilai B, Thomas LJ, Glueck RM, Saffitz JE, Vered Z, Sobel BE, Miller JG, Pérez JE. Detection of remote myocardial infarction with quantitative real-time ultrasonic characterization. J Am Soc Echocardiogr. 1988 May-Jun; 1(3):179-86. PMID: 3272768.
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  236. Myears DW, Nohara R, Abendschein DR, Saffitz JE, Sobel BE, Bergmann SR. Compromise of beneficial effects of reperfusion on myocardium supplied by vessels with critical residual stenosis. J Am Coll Cardiol. 1988 May; 11(5):1078-86. PMID: 2965715.
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  237. Bolman RM, Cance C, Spray T, Genton R, Weiss C, Saffitz J, Eisen H. The changing face of cardiac transplantation: the Washington University Program, 1985-1987. Ann Thorac Surg. 1988 Feb; 45(2):192-7. PMID: 3277556.
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  238. Miyazaki Y, Gross RW, Sobel BE, Saffitz JE. Biochemical and subcellular distribution of arachidonic acid in rat myocardium. Am J Physiol. 1987 Dec; 253(6 Pt 1):C846-53. PMID: 3122582.
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  239. Pikul FJ, Bolman RM, Saffitz JE, Chaplin H. Anti-B-mediated rejection of an ABO-incompatible cardiac allograft despite aggressive plasma exchange transfusion. Transplant Proc. 1987 Dec; 19(6):4601-4. PMID: 3321629.
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  240. Fuhrmann DR, Brown MA, Miller MI, Roysam B, Saffitz JE, Thomas LJ. Data acquisition system for maximum-likelihood analysis of electron microscopic autoradiographs. J Electron Microsc Tech. 1987 Nov; 7(3):199-204. PMID: 3504447.
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  241. Laposata M, Krueger CM, Saffitz JE. Selective uptake of [3H]arachidonic acid into the dense tubular system of human platelets. Blood. 1987 Sep; 70(3):832-7. PMID: 3113517.
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  242. Bolman RM, Spray TL, Cox JL, Kouchoukos N, Cance C, Saffitz J, Genton RE, Eisen H. Heart transplantation in patients requiring preoperative mechanical support. J Heart Transplant. 1987 Sep-Oct; 6(5):273-80. PMID: 3316551.
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  243. Sobel BE, Saffitz JE, Fields LE, Myears DW, Sarnoff SJ, Robison AK, Owensby DA, Fox KA. Intramuscular administration of human tissue-type plasminogen activator in rabbits and dogs and its implications for coronary thrombolysis. Circulation. 1987 Jun; 75(6):1261-72. PMID: 3105915.
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  244. Murphree SS, Saffitz JE. Quantitative autoradiographic delineation of the distribution of beta-adrenergic receptors in canine and feline left ventricular myocardium. Circ Res. 1987 Apr; 60(4):568-79. PMID: 3036392.
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  245. Eisen HJ, Eisenberg SB, Saffitz JE, Bolman RM, Sobel BE, Bergmann SR. Noninvasive detection of rejection of transplanted hearts with indium-111-labeled lymphocytes. Circulation. 1987 Apr; 75(4):868-76. PMID: 3030580.
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  246. Barzilai B, Saffitz JE, Miller JG, Sobel BE. Quantitative ultrasonic characterization of the nature of atherosclerotic plaques in human aorta. Circ Res. 1987 Mar; 60(3):459-63. PMID: 3555884.
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  247. Shanes JG, Ghali J, Billingham ME, Ferrans VJ, Fenoglio JJ, Edwards WD, Tsai CC, Saffitz JE, Isner J, Furner S, et al. Interobserver variability in the pathologic interpretation of endomyocardial biopsy results. Circulation. 1987 Feb; 75(2):401-5. PMID: 3802444.
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  248. Fox KA, Saffitz JE, Corr PB. Pathophysiology of myocardial reperfusion. Cardiol Clin. 1987 Feb; 5(1):31-48. PMID: 3548974.
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  249. Bolman RM, Olivari MT, Saffitz J, Sibley R, Spadaro J, Cance C, Elick B. Current results with triple therapy for heart transplantation. Transplant Proc. 1987 Feb; 19(1 Pt 3):2490-1. PMID: 3274544.
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  250. Saffitz JE, Schwartz CJ. Coronary atherosclerosis and thrombosis underlying acute myocardial infarction. Cardiol Clin. 1987 Feb; 5(1):21-30. PMID: 3548973.
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  251. Evers AS, Dunkel CG, Saffitz JE, Needleman P. Exaggerated atrial arachidonate metabolism in rabbit left ventricular myocardial infarction. J Clin Invest. 1987 Jan; 79(1):155-62. PMID: 3098782; PMCID: PMC424011.
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  252. Corr PB, Saffitz JE, Sobel BE. Lysophospholipids, long chain acylcarnitines and membrane dysfunction in the ischaemic heart. Basic Res Cardiol. 1987; 82 Suppl 1:199-208. PMID: 3311006.
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  253. Barzilai B, Eisen HJ, Saffitz JE, Pérez JE. Detection of thrombotic obstruction of a Björk-Shiley prosthesis by Doppler echocardiography. Am Heart J. 1986 Nov; 112(5):1088-90. PMID: 3776804.
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  254. Marshall WG, Saffitz J, Kouchoukos NT. Management during reoperation of aortocoronary saphenous vein grafts with minimal atherosclerosis by angiography. Ann Thorac Surg. 1986 Aug; 42(2):163-7. PMID: 3488717.
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  255. Saffitz JE, Fredrickson RC, Roberts WC. Relation of size of transmural acute myocardial infarct to mode of death, interval between infarction and death and frequency of coronary arterial thrombus. Am J Cardiol. 1986 Jun 01; 57(15):1249-54. PMID: 3717021.
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  256. Yamada KA, Saffitz JE, Corr PB. Role of alpha- and beta-adrenergic receptor stimulation in the genesis of arrhythmias during myocardial ischaemia. Eur Heart J. 1986 May; 7 Suppl A:85-90. PMID: 2873040.
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  257. Kramer JB, Saffitz JE, Corr PB. Mechanisms of arrhythmogenesis during chronic myocardial infarction. Eur Heart J. 1986 May; 7 Suppl A:149-56. PMID: 3720770.
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  258. Knabb MT, Saffitz JE, Corr PB, Sobel BE. The dependence of electrophysiological derangements on accumulation of endogenous long-chain acyl carnitine in hypoxic neonatal rat myocytes. Circ Res. 1986 Feb; 58(2):230-40. PMID: 3948341.
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  259. Schmidt RE, Plurad SB, Saffitz JE, Grabau GG, Yip HK. Retrograde axonal transport of 125I-nerve growth factor in rat ileal mesenteric nerves. Effect of streptozocin diabetes. Diabetes. 1985 Dec; 34(12):1230-40. PMID: 2415414.
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  260. Knabb MT, Ahumada GG, Sobel BE, Saffitz JE. A fixation procedure suitable for autoradiography of endogenous long-chain acyl carnitine. J Histochem Cytochem. 1985 Aug; 33(8):744-8. PMID: 4020097.
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  261. Krueger CM, Neufeld EJ, Saffitz JE. Preservation of arachidonoyl phospholipids during tissue processing for electron microscopic autoradiography. J Histochem Cytochem. 1985 Aug; 33(8):799-802. PMID: 3926867.
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  262. Neufeld EJ, Majerus PW, Krueger CM, Saffitz JE. Uptake and subcellular distribution of [3H]arachidonic acid in murine fibrosarcoma cells measured by electron microscope autoradiography. J Cell Biol. 1985 Aug; 101(2):573-81. PMID: 3926781; PMCID: PMC2113660.
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  263. King TC, Saffitz JE. Acute right ventricular infarction resulting from intracardiac infusion of hyperosmotic hyperalimentation solutions. Am J Cardiol. 1985 Jun 01; 55(13 Pt 1):1659-60. PMID: 3923816.
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  264. Kramer JB, Saffitz JE, Witkowski FX, Corr PB. Intramural reentry as a mechanism of ventricular tachycardia during evolving canine myocardial infarction. Circ Res. 1985 May; 56(5):736-54. PMID: 3995700.
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  265. Kurnik PB, Saffitz JE, Ahumada GG, Tiefenbrunn AJ, Spadaro JJ, Ludbrook PA. 19-year longevity of isolated tricuspid valve replacement. Am Heart J. 1985 Apr; 109(4):904-5. PMID: 3984844.
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  266. McCluskey ER, Murphree S, Saffitz JE, Morrison AR, Needleman P. Temporal changes in 12-HETE formation in two models of canine myocardial infarction. Prostaglandins. 1985 Mar; 29(3):387-403. PMID: 3923561.
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  267. Evers AS, Murphree S, Saffitz JE, Jakschik BA, Needleman P. Effects of endogenously produced leukotrienes, thromboxane, and prostaglandins on coronary vascular resistance in rabbit myocardial infarction. J Clin Invest. 1985 Mar; 75(3):992-9. PMID: 3980734; PMCID: PMC423645.
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  268. Shanes JG, Lyons MF, Saffitz J, Fischbein LC, Kleiger RE. Persistent endomyocardial biopsy-proven vasculitis following cure of endocarditis. Am Heart J. 1984 Sep; 108(3 Pt 1):614-9. PMID: 6475726.
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  269. Pérez JE, Barzilai B, Madaras EI, Glueck RM, Saffitz JE, Johnston P, Miller JG, Sobel BE. Applicability of ultrasonic tissue characterization for longitudinal assessment and differentiation of calcification and fibrosis in cardiomyopathy. J Am Coll Cardiol. 1984 Jul; 4(1):88-95. PMID: 6736460.
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  270. Ahumada GG, Saffitz JE. Fibronectin in rat heart: a link between cardiac myocytes and collagen. J Histochem Cytochem. 1984 Apr; 32(4):383-8. PMID: 6707462.
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  271. Sedlis SP, Saffitz JE, Schwob VS, Jaffe AS. Cardiac amyloidosis simulating hypertrophic cardiomyopathy. Am J Cardiol. 1984 Mar 15; 53(7):969-70. PMID: 6538383.
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  272. Saffitz JE, Corr PB, Lee BI, Gross RW, Williamson EK, Sobel BE. Pathophysiologic concentrations of lysophosphoglycerides quantified by electron microscopic autoradiography. Lab Invest. 1984 Mar; 50(3):278-86. PMID: 6700193.
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  273. Saffitz JE, Ganote CE, Peterson CE, Roberts WC. False aneurysm of ascending aorta after aortocoronary bypass grafting. Am J Cardiol. 1983 Oct 01; 52(7):907-9. PMID: 6605084.
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  274. Saffitz JE, Schwartz DJ, Southworth W, Murphree S, Rodriguez ER, Ferrans VJ, Roberts WC. Coxsackie viral myocarditis causing transmural right and left ventricular infarction without coronary narrowing. Am J Cardiol. 1983 Sep 01; 52(5):644, 646-7. PMID: 6310981.
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  275. Saffitz JE, Phillips ER, Temesy-Armos PN, Roberts WC. Thrombocytosis and fatal coronary heart disease. Am J Cardiol. 1983 Sep 01; 52(5):651-2. PMID: 6613895.
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  276. Sharma AD, Saffitz JE, Lee BI, Sobel BE, Corr PB. Alpha adrenergic-mediated accumulation of calcium in reperfused myocardium. J Clin Invest. 1983 Sep; 72(3):802-18. PMID: 6136527; PMCID: PMC1129245.
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  277. Saffitz JE, Ferrans VJ, Rodriguez ER, Lewis FR, Roberts WC. Histiocytoid cardiomyopathy: a cause of sudden death in apparently healthy infants. Am J Cardiol. 1983 Jul; 52(1):215-7. PMID: 6858919.
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  278. Saffitz JE, McIntosh CL, Roberts WC. Massive right ventricular outflow tract aneurysm after ventriculotomy for subvalvular pulmonic stenosis associated with peripheral pulmonary arterial stenoses. Am J Cardiol. 1983 May 01; 51(8):1460-2. PMID: 6682618.
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  279. Saffitz JE, Sazama K, Roberts WC. Amyloidosis limited to small arteries causing angina pectoris and sudden death. Am J Cardiol. 1983 Apr; 51(7):1234-5. PMID: 6837470.
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  280. Pérez JE, Saffitz JE, Gutiérrez FA, Henry PD. Coronary artery spasm in intact dogs induced by potassium and serotonin. Circ Res. 1983 Apr; 52(4):423-31. PMID: 6299610.
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  281. Saffitz JE, Rose TE, Oaks JB, Roberts WC. Coronary arterial rupture during coronary angioplasty. Am J Cardiol. 1983 Mar 01; 51(5):902-4. PMID: 6219571.
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  282. McCluskey ER, Corr PB, Lee BI, Saffitz JE, Needleman P. The arachidonic acid metabolic capacity of canine myocardium is increased during healing of acute myocardial infarction. Circ Res. 1982 Dec; 51(6):743-50. PMID: 7139887.
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  283. Gross RW, Corr PB, Lee BI, Saffitz JE, Crafford WA, Sobel BE. Incorporation of radiolabeled lysophosphatidyl choline into canine Purkinje fibers and ventricular muscle. Electrophysiological, biochemical, and autoradiographic correlations. Circ Res. 1982 Jul; 51(1):27-36. PMID: 7083488.
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  284. Lerch RA, Bergmann SR, Carlson EM, Saffitz JE, Sobel BE. Monitoring of cardiac antirejection therapy with In-111 lymphocytes. J Nucl Med. 1982 Jun; 23(6):496-500. PMID: 7042935.
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  285. Bergmann SR, Lerch RA, Carlson EM, Saffitz JE, Sobel BE. Detection of cardiac transplant rejection with radiolabeled lymphocytes. Circulation. 1982 Mar; 65(3):591-9. PMID: 7034991.
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  286. Saffitz JE, Totty WG, McClennan BL, Gilula LA. Percutaneous transluminal angioplasty. Radiological-pathological correlation. Radiology. 1981 Dec; 141(3):651-4. PMID: 6458065.
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  287. Saffitz JE, Gross RW, Williamson JR, Sobel BE. Autoradiography of phosphatidyl choline. J Histochem Cytochem. 1981 Mar; 29(3):371-8. PMID: 7240719.
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  288. Saffitz JE, Caplan AI. Separation of transcriptively active and inactive chromatin. Agarose gel chromatography. Biochim Biophys Acta. 1978 Sep 27; 520(2):368-75. PMID: 568486.
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  289. Saffitz JE, Caplan AI. Hydroxylapatite thermal fractionation of chromatin and DNA. Biochemistry. 1978 Aug 22; 17(17):3480-6. PMID: 567488.
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  290. Saffitz JE, Caplan AI. Attempted separation of transcriptively active and inactive chromatin by hydroxylapatite thermal chromatography. Biochemistry. 1978 Aug 22; 17(17):3487-95. PMID: 567489.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.