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Saffitz, Jeffrey
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Jeffrey E Saffitz, M.D., Ph.D.
Title
Mallinckrodt Professor of Pathology
Institution
Beth Israel Deaconess Medical Center
Department
Pathology
Address
Beth Israel Deaconess Med Ctr
Finard 207, Pathology
330 Brookline Ave
Boston MA 02215
Phone
617/667-4343
Fax
617/667-2943
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Other Positions
Title
Head of the Department of Pathology at Beth Israel Deaconess Medical Center
Institution
Beth Israel Deaconess Medical Center
Department
Pathology
Title
Professor of Pathology
Institution
Beth Israel Deaconess Medical Center
Department
Pathology
research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01HL148348
(SAFFITZ, JEFFREY E)
Apr 1, 2020 - Mar 31, 2024
NIH
Arrhythmogenic Cardiomyopathy is an Inflammatory Disease
Role: Principal Investigator
R01HL136463
(SAFFITZ, JEFFREY E)
Jul 15, 2018 - Jun 30, 2022
NIH
Altered Cell-Cell Coupling in Arrhythmogenic Cardiomyopathy
Role: Principal Investigator
R01HL116906
(TOWBIN, JEFFREY ALLEN)
Aug 23, 2013 - Jun 30, 2019
NIH
Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
Role: Co-Principal Investigator
R01HL102361
(SAFFITZ, JEFFREY E)
Apr 1, 2010 - Sep 30, 2014
NIH
Disease Mechanisms in ARVC
Role: Principal Investigator
RC1HL100110
(SAFFITZ, JEFFREY E)
Sep 30, 2009 - Aug 31, 2012
NIH
Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
Role: Principal Investigator
R01HL058507
(SAFFITZ, JEFFREY E)
Apr 1, 1998 - Dec 31, 2008
NIH
Cx43 in a Genetic Model of Altered Myocardial Conduction
Role: Principal Investigator
S10RR012911
(SAFFITZ, JEFFREY E)
Apr 1, 1998 - Mar 31, 2001
NIH
MULTISITE OPTICAL MAPPING SYSTEM
Role: Principal Investigator
P01HL057278
(GROSS, RICHARD W)
Sep 30, 1996 - May 31, 2014
NIH/NHLBI
Membrane-Mediated Alterations in Diabetes
Role: Co-Principal Investigator
R01HL050598
(SAFFITZ, JEFFREY E)
Dec 29, 1994 - Jun 30, 2009
NIH
Regulation of Myocardial Gap Junctions
Role: Principal Investigator
S10RR003989
(SAFFITZ, JEFFREY E)
Jan 11, 1988 - Jun 30, 1990
NIH
ELECTRON MICROSCOPE
Role: Principal Investigator
P60HL017646
(SOBEL, BURTON E)
Sep 30, 1984 - Dec 31, 1989
NIH/NHLBI
SPECIALIZED CENTER OF RESEARCH, ISCHEMIC HEART DISEASE
Role: Co-Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Bueno-Beti C, Field E, Tsatsopoulou A, Perry G, Sheppard MN, Behr ER,
Saffitz JE
, Kaski JP, Asimaki A. Analysis of buccal mucosa as a prognostic tool in children with arrhythmogenic cardiomyopathy. Prog Pediatr Cardiol. 2022 Mar; 64:None.
PMID:
35300203
.
Citations:
Hawthorne RN,
Blazeski A
, Lowenthal J, Kannan S, Teuben R, DiSilvestre D, Morrissette-McAlmon J,
Saffitz JE
, Boheler KR, James CA, Chelko SP, Tomaselli G, Tung L. Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC. J Clin Med. 2021 Jul 10; 10(14).
PMID:
34300226
.
Citations:
1
Chelko SP,
Saffitz JE
. Role of galectin-3 in the pathogenesis of arrhythmogenic cardiomyopathy-It's complicated. Heart Rhythm. 2021 08; 18(8):1404-1405.
PMID:
33905812
.
Citations:
Fields:
Car
Cardiology
Translation:
Humans
Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E,
Saffitz JE
, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N. Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021 02 17; 13(581).
PMID:
33597260
.
Citations:
11
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Corradi D,
Saffitz JE
, Novelli D, Asimaki A, Simon C, Oldoni E, Masson S, Meessen JMTA, Monaco R, Manuguerra R, Latini R,
Libby P
, Tavazzi L, Marchioli R, Dozza L, Cavallotti L, Aleksova A, Gregorini R, Mozaffarian D. Prospective Evaluation of Clinico-Pathological Predictors of Postoperative Atrial Fibrillation: An Ancillary Study From the OPERA Trial. Circ Arrhythm Electrophysiol. 2020 08; 13(8):e008382.
PMID:
32654517
.
Citations:
1
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Lerchenmüller C, Rabolli CP, Yeri A,
Kitchen R
, Salvador AM, Liu LX, Ziegler O, Danielson K,
Platt C
, Shah R, Damilano F, Kundu P, Riechert E, Katus HA,
Saffitz JE
, Keshishian H, Carr SA,
Bezzerides VJ
,
Das S
,
Rosenzweig A
. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020 08 14; 127(5):631-646.
PMID:
32418505
.
Citations:
7
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Shaw RM,
Saffitz JE
. A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 04 01; 130(4):1608-1610.
PMID:
32091412
.
Citations:
3
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Camors EM, Purevjav E, Jefferies JL,
Saffitz JE
, Gong N, Ryan TD, Lucky AW, Taylor MD, Sullivan LM, Mestroni L, Towbin JA. Early Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2020 04; 13(2):e002800.
PMID:
32164419
.
Citations:
1
Fields:
Car
Cardiology
Gen
Genetics
Vas
Vascular Diseases
Translation:
Humans
Towbin JA, McKenna WJ,
Abrams DJ
, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG,
Saffitz JE
, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. 2019 11; 16(11):e373-e407.
PMID:
31676023
.
Citations:
39
Fields:
Car
Cardiology
Translation:
Humans
Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L,
Saffitz JE
. Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy. Circulation. 2019 10 29; 140(18):1491-1505.
PMID:
31533459
.
Citations:
39
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Animals
Cells
Austin KM
,
Trembley MA
, Chandler SF,
Sanders SP
,
Saffitz JE
,
Abrams DJ
,
Pu WT
. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537.
PMID:
31028357
.
Citations:
49
Fields:
Car
Cardiology
Translation:
Humans
Animals
Cells
Barkagan M, Leshem E, Shapira-Daniels A, Sroubek J,
Buxton AE
,
Saffitz JE
, Anter E. Histopathological Characterization of Radiofrequency Ablation in Ventricular Scar Tissue. JACC Clin Electrophysiol. 2019 08; 5(8):920-931.
PMID:
31439293
.
Citations:
8
Fields:
Car
Cardiology
Translation:
Animals
Towbin JA, McKenna WJ,
Abrams DJ
, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG,
Saffitz JE
, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 11; 16(11):e301-e372.
PMID:
31078652
.
Citations:
122
Fields:
Car
Cardiology
Translation:
Humans
Thiene G,
Saffitz JE
. Response by Thiene and Saffitz to Letter Regarding Article, "Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now". Circulation. 2019 01 22; 139(4):568-569.
PMID:
30664373
.
Citations:
Fields:
Car
Cardiology
Vas
Vascular Diseases
Te Rijdt WP, Asimaki A, Jongbloed JDH, Hoorntje ET, Lazzarini E, van der Zwaag PA, de Boer RA, van Tintelen JP,
Saffitz JE
, van den Berg MP, Suurmeijer AJH. Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2019 May - Jun; 40:2-6.
PMID:
30763825
.
Citations:
8
Fields:
Car
Cardiology
Pat
Pathology
Vas
Vascular Diseases
Translation:
Humans
Cells
Saffitz JE
. Editorial commentary: Nuclear receptors and a network biology approach to understanding and treating heart disease. Trends Cardiovasc Med. 2019 11; 29(8):438-439.
PMID:
30559047
.
Citations:
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Thiene G,
Saffitz JE
. Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now. Circulation. 2018 06 19; 137(25):2683-2685.
PMID:
29915093
.
Citations:
2
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans
Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR,
Saffitz JE
, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 04; 4(4):504-514.
PMID:
30067491
.
Citations:
49
Fields:
Car
Cardiology
Translation:
Humans
Cells
Saffitz JE
. Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2017 May - Jun; 28:51-58.
PMID:
28319834
.
Citations:
2
Fields:
Car
Cardiology
Pat
Pathology
Vas
Vascular Diseases
Translation:
Humans
Animals
Cells
Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB,
Das S
,
Saffitz J
, Arany Z. Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRß. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H662-H671.
PMID:
28130335
.
Citations:
8
Fields:
Car
Cardiology
Phy
Physiology
Translation:
Humans
Animals
Cells
Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R,
MacRae CA
, Leber R,
Kleber AG
,
Saffitz JE
, Judge DP. Central role for GSK3ß in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016 Apr 21; 1(5).
PMID:
27170944
.
Citations:
53
Fields:
Med
Medicine (General)
Almomani R, Verhagen JM, Herkert JC, Brosens E, van Spaendonck-Zwarts KY, Asimaki A, van der Zwaag PA, Frohn-Mulder IM, Bertoli-Avella AM, Boven LG, van Slegtenhorst MA, van der Smagt JJ, van IJcken WF, Timmer B, van Stuijvenberg M, Verdijk RM,
Saffitz JE
, du Plessis FA, Michels M, Hofstra RM, Sinke RJ, van Tintelen JP, Wessels MW, Jongbloed JD, van de Laar IM. Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy. J Am Coll Cardiol. 2016 Feb 09; 67(5):515-25.
PMID:
26846950
.
Citations:
24
Fields:
Car
Cardiology
Translation:
Humans
Animals
Cells
Asimaki A, Protonotarios A, James CA, Chelko SP, Tichnell C, Murray B, Tsatsopoulou A, Anastasakis A, te Riele A, Kléber AG, Judge DP, Calkins H,
Saffitz JE
. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003688.
PMID:
26850880
.
Citations:
17
Fields:
Car
Cardiology
Vas
Vascular Diseases
Translation:
Humans