Harvard Catalyst Profiles

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Jeffrey E Saffitz, M.D., Ph.D.

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Other Positions
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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL148348 (SAFFITZ, JEFFREY E) Apr 1, 2020 - Mar 31, 2024
    NIH
    Arrhythmogenic Cardiomyopathy is an Inflammatory Disease
    Role: Principal Investigator
  2. R01HL136463 (SAFFITZ, JEFFREY E) Jul 15, 2018 - Jun 30, 2022
    NIH
    Altered Cell-Cell Coupling in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator
  3. R01HL116906 (TOWBIN, JEFFREY ALLEN) Aug 23, 2013 - Jun 30, 2019
    NIH
    Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
    Role: Co-Principal Investigator
  4. R01HL102361 (SAFFITZ, JEFFREY E) Apr 1, 2010 - Sep 30, 2014
    NIH
    Disease Mechanisms in ARVC
    Role: Principal Investigator
  5. RC1HL100110 (SAFFITZ, JEFFREY E) Sep 30, 2009 - Aug 31, 2012
    NIH
    Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hawthorne RN, Blazeski A, Lowenthal J, Kannan S, Teuben R, DiSilvestre D, Morrissette-McAlmon J, Saffitz JE, Boheler KR, James CA, Chelko SP, Tomaselli G, Tung L. Altered Electrical, Biomolecular, and Immunologic Phenotypes in a Novel Patient-Derived Stem Cell Model of Desmoglein-2 Mutant ARVC. J Clin Med. 2021 Jul 10; 10(14). PMID: 34300226.
    Citations:    
  2. Chelko SP, Saffitz JE. Role of galectin-3 in the pathogenesis of arrhythmogenic cardiomyopathy-It's complicated. Heart Rhythm. 2021 Aug; 18(8):1404-1405. PMID: 33905812.
    Citations:    Fields:    
  3. Chelko SP, Keceli G, Carpi A, Doti N, Agrimi J, Asimaki A, Beti CB, Miyamoto M, Amat-Codina N, Bedja D, Wei AC, Murray B, Tichnell C, Kwon C, Calkins H, James CA, O'Rourke B, Halushka MK, Melloni E, Saffitz JE, Judge DP, Ruvo M, Kitsis RN, Andersen P, Di Lisa F, Paolocci N. Exercise triggers CAPN1-mediated AIF truncation, inducing myocyte cell death in arrhythmogenic cardiomyopathy. Sci Transl Med. 2021 02 17; 13(581). PMID: 33597260.
    Citations: 5     Fields:    Translation:AnimalsCells
  4. Corradi D, Saffitz JE, Novelli D, Asimaki A, Simon C, Oldoni E, Masson S, Meessen JMTA, Monaco R, Manuguerra R, Latini R, Libby P, Tavazzi L, Marchioli R, Dozza L, Cavallotti L, Aleksova A, Gregorini R, Mozaffarian D. Prospective Evaluation of Clinico-Pathological Predictors of Postoperative Atrial Fibrillation: An Ancillary Study From the OPERA Trial. Circ Arrhythm Electrophysiol. 2020 08; 13(8):e008382. PMID: 32654517.
    Citations:    Fields:    Translation:Humans
  5. Lerchenmüller C, Rabolli CP, Yeri A, Kitchen R, Salvador AM, Liu LX, Ziegler O, Danielson K, Platt C, Shah R, Damilano F, Kundu P, Riechert E, Katus HA, Saffitz JE, Keshishian H, Carr SA, Bezzerides VJ, Das S, Rosenzweig A. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020 08 14; 127(5):631-646. PMID: 32418505.
    Citations: 5     Fields:    Translation:AnimalsCells
  6. Shaw RM, Saffitz JE. A role for connexin-43 in Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 04 01; 130(4):1608-1610. PMID: 32091412.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Camors EM, Purevjav E, Jefferies JL, Saffitz JE, Gong N, Ryan TD, Lucky AW, Taylor MD, Sullivan LM, Mestroni L, Towbin JA. Early Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2020 04; 13(2):e002800. PMID: 32164419.
    Citations:    Fields:    Translation:Humans
  8. Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. 2019 11; 16(11):e373-e407. PMID: 31676023.
    Citations: 33     Fields:    Translation:Humans
  9. Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L, Saffitz JE. Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy. Circulation. 2019 10 29; 140(18):1491-1505. PMID: 31533459.
    Citations: 30     Fields:    Translation:AnimalsCells
  10. Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. PMID: 31028357.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  11. Barkagan M, Leshem E, Shapira-Daniels A, Sroubek J, Buxton AE, Saffitz JE, Anter E. Histopathological Characterization of Radiofrequency Ablation in Ventricular Scar Tissue. JACC Clin Electrophysiol. 2019 08; 5(8):920-931. PMID: 31439293.
    Citations: 7     Fields:    Translation:Animals
  12. Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 11; 16(11):e301-e372. PMID: 31078652.
    Citations: 89     Fields:    Translation:Humans
  13. Thiene G, Saffitz JE. Response by Thiene and Saffitz to Letter Regarding Article, "Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now". Circulation. 2019 01 22; 139(4):568-569. PMID: 30664373.
    Citations:    Fields:    
  14. Te Rijdt WP, Asimaki A, Jongbloed JDH, Hoorntje ET, Lazzarini E, van der Zwaag PA, de Boer RA, van Tintelen JP, Saffitz JE, van den Berg MP, Suurmeijer AJH. Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2019 May - Jun; 40:2-6. PMID: 30763825.
    Citations: 4     Fields:    Translation:HumansCells
  15. Saffitz JE. Editorial commentary: Nuclear receptors and a network biology approach to understanding and treating heart disease. Trends Cardiovasc Med. 2019 11; 29(8):438-439. PMID: 30559047.
    Citations:    Fields:    Translation:Humans
  16. Thiene G, Saffitz JE. Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now. Circulation. 2018 06 19; 137(25):2683-2685. PMID: 29915093.
    Citations: 1     Fields:    Translation:Humans
  17. Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 04; 4(4):504-514. PMID: 30067491.
    Citations: 37     Fields:    Translation:HumansCells
  18. Saffitz JE. Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2017 May - Jun; 28:51-58. PMID: 28319834.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz J, Arany Z. Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRß. . 2017 Apr 01; 312(4):H662-H671. PMID: 28130335.
    Citations: 6     Translation:HumansAnimalsCells
  20. Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP. Central role for GSK3ß in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016 Apr 21; 1(5). PMID: 27170944.
    Citations: 44     Fields:    
  21. Almomani R, Verhagen JM, Herkert JC, Brosens E, van Spaendonck-Zwarts KY, Asimaki A, van der Zwaag PA, Frohn-Mulder IM, Bertoli-Avella AM, Boven LG, van Slegtenhorst MA, van der Smagt JJ, van IJcken WF, Timmer B, van Stuijvenberg M, Verdijk RM, Saffitz JE, du Plessis FA, Michels M, Hofstra RM, Sinke RJ, van Tintelen JP, Wessels MW, Jongbloed JD, van de Laar IM. Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy. J Am Coll Cardiol. 2016 Feb 09; 67(5):515-25. PMID: 26846950.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  22. Asimaki A, Protonotarios A, James CA, Chelko SP, Tichnell C, Murray B, Tsatsopoulou A, Anastasakis A, te Riele A, Kléber AG, Judge DP, Calkins H, Saffitz JE. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003688. PMID: 26850880.
    Citations: 12     Fields:    Translation:HumansCells
  23. Siqueira WC, da Cruz SG, Asimaki A, Saffitz JE, Moreira Mda C, Brasileiro G, Rocha LO. Cardiac sarcoidosis with severe involvement of the right ventricle: a case report. Autops Case Rep. 2015 Oct-Dec; 5(4):53-63. PMID: 26894046.
    Citations: 1     
  24. Saffitz JE, Corradi D. The electrical heart: 25 years of discovery in cardiac electrophysiology, arrhythmias and sudden death. Cardiovasc Pathol. 2016 Mar-Apr; 25(2):149-57. PMID: 26764149.
    Citations: 2     Fields:    Translation:HumansAnimals
  25. Spezzacatene A, Sinagra G, Merlo M, Barbati G, Graw SL, Brun F, Slavov D, Di Lenarda A, Salcedo EE, Towbin JA, Saffitz JE, Marcus FI, Zareba W, Taylor MR, Mestroni L. Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life-Threatening Arrhythmias. J Am Heart Assoc. 2015 Oct 16; 4(10):e002149. PMID: 26475296.
    Citations: 32     Fields:    Translation:Humans
  26. Ahmad T, Yin P, Saffitz J, Pockros PJ, Lalezari J, Shiffman M, Freilich B, Zamparo J, Brown K, Dimitrova D, Kumar M, Manion D, Heath-Chiozzi M, Wolf R, Hughes E, Muir AJ, Hernandez AF. Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C. Hepatology. 2015 Aug; 62(2):409-16. PMID: 25251156.
    Citations: 19     Fields:    Translation:HumansCellsCTClinical Trials