Harvard Catalyst Profiles

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Jeffrey E Saffitz, M.D., Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL148348 (SAFFITZ, JEFFREY E) Apr 1, 2020 - Mar 31, 2024
    Arrhythmogenic Cardiomyopathy is an Inflammatory Disease
    Role: Principal Investigator
  2. R01HL136463 (SAFFITZ, JEFFREY E) Jul 15, 2018 - Jun 30, 2022
    Altered Cell-Cell Coupling in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator
  3. R01HL116906 (TOWBIN, JEFFREY ALLEN) Aug 23, 2013 - Jun 30, 2017
    Genetics, Mechanisms and Clinical Phenotypes of Arrhythmogenic Cardiomyopathy
    Role: Co-Principal Investigator
  4. R01HL102361 (SAFFITZ, JEFFREY E) Apr 1, 2010 - Mar 31, 2014
    Disease Mechanisms in ARVC
    Role: Principal Investigator
  5. RC1HL100110 (SAFFITZ, JEFFREY E) Sep 30, 2009 - Aug 31, 2012
    Determinants of Disease Expression in Arrhythmogenic Cardiomyopathy
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lerchenmüller C, Rabolli CP, Yeri AS, Kitchen R, Salvador AM, Liu LX, Ziegler O, Danielson KM, Platt C, Shah R, Damilano F, Kundu P, Riechert E, Katus HA, Saffitz JE, Keshishian H, Carr S, Bezzerides VJ, Das S, Rosenzweig A. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress. Circ Res. 2020 May 18. PMID: 32418505.
  2. Camors EM, Purevjav E, Jefferies JL, Saffitz JE, Gong N, Ryan TD, Lucky AW, Taylor MD, Sullivan LM, Mestroni L, Towbin JA. Early Lethality Due to a Novel Desmoplakin Variant Causing Infantile Epidermolysis Bullosa Simplex With Fragile Skin, Aplasia Cutis Congenita, and Arrhythmogenic Cardiomyopathy. Circ Genom Precis Med. 2020 Apr; 13(2):e002800. PMID: 32164419.
  3. Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary. Heart Rhythm. 2019 11; 16(11):e373-e407. PMID: 31676023.
  4. Chelko SP, Asimaki A, Lowenthal J, Bueno-Beti C, Bedja D, Scalco A, Amat-Alarcon N, Andersen P, Judge DP, Tung L, Saffitz JE. Therapeutic Modulation of the Immune Response in Arrhythmogenic Cardiomyopathy. Circulation. 2019 Oct 29; 140(18):1491-1505. PMID: 31533459.
  5. Austin KM, Trembley MA, Chandler SF, Sanders SP, Saffitz JE, Abrams DJ, Pu WT. Molecular mechanisms of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2019 09; 16(9):519-537. PMID: 31028357.
  6. Barkagan M, Leshem E, Shapira-Daniels A, Sroubek J, Buxton AE, Saffitz JE, Anter E. Histopathological Characterization of Radiofrequency Ablation in Ventricular Scar Tissue. JACC Clin Electrophysiol. 2019 08; 5(8):920-931. PMID: 31439293.
  7. Towbin JA, McKenna WJ, Abrams DJ, Ackerman MJ, Calkins H, Darrieux FCC, Daubert JP, de Chillou C, DePasquale EC, Desai MY, Estes NAM, Hua W, Indik JH, Ingles J, James CA, John RM, Judge DP, Keegan R, Krahn AD, Link MS, Marcus FI, McLeod CJ, Mestroni L, Priori SG, Saffitz JE, Sanatani S, Shimizu W, van Tintelen JP, Wilde AAM, Zareba W. 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm. 2019 11; 16(11):e301-e372. PMID: 31078652.
  8. Thiene G, Saffitz JE. Response by Thiene and Saffitz to Letter Regarding Article, "Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now". Circulation. 2019 01 22; 139(4):568-569. PMID: 30664373.
    Citations:    Fields:    
  9. Te Rijdt WP, Asimaki A, Jongbloed JDH, Hoorntje ET, Lazzarini E, van der Zwaag PA, de Boer RA, van Tintelen JP, Saffitz JE, van den Berg MP, Suurmeijer AJH. Distinct molecular signature of phospholamban p.Arg14del arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2019 May - Jun; 40:2-6. PMID: 30763825.
  10. Saffitz JE. Editorial commentary: Nuclear receptors and a network biology approach to understanding and treating heart disease. Trends Cardiovasc Med. 2019 11; 29(8):438-439. PMID: 30559047.
    Citations:    Fields:    
  11. Thiene G, Saffitz JE. Autopsy as a Source of Discovery in Cardiovascular Medicine: Then and Now. Circulation. 2018 06 19; 137(25):2683-2685. PMID: 29915093.
    Citations:    Fields:    
  12. Begay RL, Graw SL, Sinagra G, Asimaki A, Rowland TJ, Slavov DB, Gowan K, Jones KL, Brun F, Merlo M, Miani D, Sweet M, Devaraj K, Wartchow EP, Gigli M, Puggia I, Salcedo EE, Garrity DM, Ambardekar AV, Buttrick P, Reece TB, Bristow MR, Saffitz JE, Mestroni L, Taylor MRG. Filamin C Truncation Mutations Are Associated With Arrhythmogenic Dilated Cardiomyopathy and Changes in the Cell-Cell Adhesion Structures. JACC Clin Electrophysiol. 2018 04; 4(4):504-514. PMID: 30067491.
    Citations: 1     
  13. Saffitz JE. Molecular mechanisms in the pathogenesis of arrhythmogenic cardiomyopathy. Cardiovasc Pathol. 2017 May - Jun; 28:51-58. PMID: 28319834.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Rowe GC, Asimaki A, Graham EL, Martin KD, Margulies KB, Das S, Saffitz J, Arany Z. Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRRß. Am J Physiol Heart Circ Physiol. 2017 Apr 01; 312(4):H662-H671. PMID: 28130335.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  15. Chelko SP, Asimaki A, Andersen P, Bedja D, Amat-Alarcon N, DeMazumder D, Jasti R, MacRae CA, Leber R, Kleber AG, Saffitz JE, Judge DP. Central role for GSK3ß in the pathogenesis of arrhythmogenic cardiomyopathy. JCI Insight. 2016 Apr 21; 1(5). PMID: 27170944.
    Citations: 12     Fields:    
  16. Almomani R, Verhagen JM, Herkert JC, Brosens E, van Spaendonck-Zwarts KY, Asimaki A, van der Zwaag PA, Frohn-Mulder IM, Bertoli-Avella AM, Boven LG, van Slegtenhorst MA, van der Smagt JJ, van IJcken WF, Timmer B, van Stuijvenberg M, Verdijk RM, Saffitz JE, du Plessis FA, Michels M, Hofstra RM, Sinke RJ, van Tintelen JP, Wessels MW, Jongbloed JD, van de Laar IM. Biallelic Truncating Mutations in ALPK3 Cause Severe Pediatric Cardiomyopathy. J Am Coll Cardiol. 2016 Feb 09; 67(5):515-25. PMID: 26846950.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Asimaki A, Protonotarios A, James CA, Chelko SP, Tichnell C, Murray B, Tsatsopoulou A, Anastasakis A, te Riele A, Kléber AG, Judge DP, Calkins H, Saffitz JE. Characterizing the Molecular Pathology of Arrhythmogenic Cardiomyopathy in Patient Buccal Mucosa Cells. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003688. PMID: 26850880.
    Citations: 2     Fields:    Translation:HumansCells
  18. Siqueira WC, da Cruz SG, Asimaki A, Saffitz JE, Moreira Mda C, Brasileiro G, Rocha LO. Cardiac sarcoidosis with severe involvement of the right ventricle: a case report. Autops Case Rep. 2015 Oct-Dec; 5(4):53-63. PMID: 26894046.
  19. Saffitz JE, Corradi D. The electrical heart: 25 years of discovery in cardiac electrophysiology, arrhythmias and sudden death. Cardiovasc Pathol. 2016 Mar-Apr; 25(2):149-57. PMID: 26764149.
    Citations: 2     Fields:    Translation:HumansAnimals
  20. Spezzacatene A, Sinagra G, Merlo M, Barbati G, Graw SL, Brun F, Slavov D, Di Lenarda A, Salcedo EE, Towbin JA, Saffitz JE, Marcus FI, Zareba W, Taylor MR, Mestroni L. Arrhythmogenic Phenotype in Dilated Cardiomyopathy: Natural History and Predictors of Life-Threatening Arrhythmias. J Am Heart Assoc. 2015 Oct 16; 4(10):e002149. PMID: 26475296.
    Citations: 10     Fields:    Translation:Humans
  21. Ahmad T, Yin P, Saffitz J, Pockros PJ, Lalezari J, Shiffman M, Freilich B, Zamparo J, Brown K, Dimitrova D, Kumar M, Manion D, Heath-Chiozzi M, Wolf R, Hughes E, Muir AJ, Hernandez AF. Cardiac dysfunction associated with a nucleotide polymerase inhibitor for treatment of hepatitis C. Hepatology. 2015 Aug; 62(2):409-16. PMID: 25251156.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  22. Asimaki A, Kleber AG, Saffitz JE. Pathogenesis of Arrhythmogenic Cardiomyopathy. Can J Cardiol. 2015 Nov; 31(11):1313-24. PMID: 26199027.
    Citations: 5     Fields:    Translation:Humans
  23. Saffitz JE. Protein trafficking in cardiovascular disease: How the science has evolved and where it must go. Trends Cardiovasc Med. 2015 Jul; 25(5):390-1. PMID: 25666491.
    Citations:    Fields:    Translation:HumansCells
  24. Asimaki A, Kléber AG, MacRae CA, Saffitz JE. Arrhythmogenic Cardiomyopathy - New Insights into Disease Mechanisms and Drug Discovery. Prog Pediatr Cardiol. 2014 Dec 01; 37(1-2):3-7. PMID: 25506190.
    Citations: 1     
  25. Kleber AG, Saffitz JE. Role of the intercalated disc in cardiac propagation and arrhythmogenesis. Front Physiol. 2014; 5:404. PMID: 25368581.
    Citations: 12     
  26. Hariharan V, Asimaki A, Michaelson JE, Plovie E, MacRae CA, Saffitz JE, Huang H. Arrhythmogenic right ventricular cardiomyopathy mutations alter shear response without changes in cell-cell adhesion. Cardiovasc Res. 2014 Nov 01; 104(2):280-9. PMID: 25253076.
    Citations: 8     Fields:    Translation:AnimalsCells
  27. Asimaki A, Kapoor S, Plovie E, Karin Arndt A, Adams E, Liu Z, James CA, Judge DP, Calkins H, Churko J, Wu JC, MacRae CA, Kléber AG, Saffitz JE. Identification of a new modulator of the intercalated disc in a zebrafish model of arrhythmogenic cardiomyopathy. Sci Transl Med. 2014 Jun 11; 6(240):240ra74. PMID: 24920660.
    Citations: 52     Fields:    Translation:AnimalsCells
  28. Saffitz JE, Sanders SP. Postmortem analysis of structural heart defects in fetuses and children by magnetic resonance imaging: an alternative to autopsy? Circulation. 2014 May 13; 129(19):1909-11. PMID: 24647276.
    Citations:    Fields:    Translation:Humans
  29. Corradi D, Callegari S, Manotti L, Ferrara D, Goldoni M, Alinovi R, Pinelli S, Mozzoni P, Andreoli R, Asimaki A, Pozzoli A, Becchi G, Mutti A, Benussi S, Saffitz JE, Alfieri O. Persistent lone atrial fibrillation: clinicopathologic study of 19 cases. Heart Rhythm. 2014 Jul; 11(7):1250-8. PMID: 24560692.
    Citations: 9     Fields:    Translation:Humans
  30. Asimaki A, Saffitz JE. Remodeling of cell-cell junctions in arrhythmogenic cardiomyopathy. Cell Commun Adhes. 2014 Feb; 21(1):13-23. PMID: 24460198.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  31. Haspel RL, Saffitz JE. Genomic oncology education: an urgent need, a new approach. Cancer J. 2014 Jan-Feb; 20(1):91-5. PMID: 24445771.
    Citations: 5     Fields:    Translation:Humans
  32. Noorman M, Hakim S, Asimaki A, Vreeker A, van Rijen HV, van der Heyden MA, de Jonge N, de Weger RA, Hauer RN, Saffitz JE, van Veen TA. Reduced plakoglobin immunoreactivity in arrhythmogenic cardiomyopathy: methodological considerations. Cardiovasc Pathol. 2013 Sep-Oct; 22(5):314-8. PMID: 23688911.
    Citations: 2     Fields:    Translation:HumansCells
  33. Park JK, Rosen A, Saffitz JE, Asimaki A, Litovsky SH, Mackey-Bojack SM, Halushka MK. Expression of cathepsin K and tartrate-resistant acid phosphatase is not confined to osteoclasts but is a general feature of multinucleated giant cells: systematic analysis. Rheumatology (Oxford). 2013 Aug; 52(8):1529-33. PMID: 23674817.
    Citations: 6     Fields:    Translation:HumansCells
  34. Noorman M, Hakim S, Kessler E, Groeneweg JA, Cox MG, Asimaki A, van Rijen HV, van Stuijvenberg L, Chkourko H, van der Heyden MA, Vos MA, de Jonge N, van der Smagt JJ, Dooijes D, Vink A, de Weger RA, Varro A, de Bakker JM, Saffitz JE, Hund TJ, Mohler PJ, Delmar M, Hauer RN, van Veen TA. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Heart Rhythm. 2013 Mar; 10(3):412-9. PMID: 23178689.
    Citations: 36     Fields:    Translation:HumansCells
  35. Noorman M, Groeneweg JA, Asimaki A, Rizzo S, Papegaaij M, van Stuijvenberg L, de Jonge N, Dooijes D, Basso C, Saffitz JE, van Veen TA, Vink A, Hauer RN. End stage of arrhythmogenic cardiomyopathy with severe involvement of the interventricular septum. Heart Rhythm. 2013 Feb; 10(2):283-9. PMID: 23085127.
    Citations: 1     Fields:    Translation:Humans
  36. Saffitz JE, Kléber AG. Gap junctions, slow conduction, and ventricular tachycardia after myocardial infarction. J Am Coll Cardiol. 2012 Sep 18; 60(12):1111-3. PMID: 22883635.
    Citations: 8     Fields:    Translation:Animals
  37. van der Zwaag PA, van Rijsingen IA, Asimaki A, Jongbloed JD, van Veldhuisen DJ, Wiesfeld AC, Cox MG, van Lochem LT, de Boer RA, Hofstra RM, Christiaans I, van Spaendonck-Zwarts KY, Lekanne dit Deprez RH, Judge DP, Calkins H, Suurmeijer AJ, Hauer RN, Saffitz JE, Wilde AA, van den Berg MP, van Tintelen JP. Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy. Eur J Heart Fail. 2012 Nov; 14(11):1199-207. PMID: 22820313.
    Citations: 59     Fields:    Translation:Humans
  38. Saffitz JE. Genomic pathology: a disruptive innovation. Per Med. 2012 May; 9(3):237-239. PMID: 29758788.
  39. Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. Circ Res. 2012 May 25; 110(11):1445-53. PMID: 22518032.
    Citations: 12     Fields:    Translation:AnimalsCells
  40. Gomes J, Finlay M, Ahmed AK, Ciaccio EJ, Asimaki A, Saffitz JE, Quarta G, Nobles M, Syrris P, Chaubey S, McKenna WJ, Tinker A, Lambiase PD. Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur Heart J. 2012 Aug; 33(15):1942-53. PMID: 22240500.
    Citations: 40     Fields:    Translation:HumansAnimals
  41. Van Norstrand DW, Asimaki A, Rubinos C, Dolmatova E, Srinivas M, Tester DJ, Saffitz JE, Duffy HS, Ackerman MJ. Connexin43 mutation causes heterogeneous gap junction loss and sudden infant death. Circulation. 2012 Jan 24; 125(3):474-81. PMID: 22179534.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  42. Leone O, Veinot JP, Angelini A, Baandrup UT, Basso C, Berry G, Bruneval P, Burke M, Butany J, Calabrese F, d'Amati G, Edwards WD, Fallon JT, Fishbein MC, Gallagher PJ, Halushka MK, McManus B, Pucci A, Rodriguez ER, Saffitz JE, Sheppard MN, Steenbergen C, Stone JR, Tan C, Thiene G, van der Wal AC, Winters GL. 2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology. Cardiovasc Pathol. 2012 Jul-Aug; 21(4):245-74. PMID: 22137237.
    Citations: 48     Fields:    Translation:Humans
  43. Asimaki A, Saffitz JE. Gap junctions and arrhythmogenic cardiomyopathy. Heart Rhythm. 2012 Jun; 9(6):992-5. PMID: 22100709.
    Citations: 5     Fields:    Translation:HumansCells
  44. Gehmlich K, Syrris P, Reimann M, Asimaki A, Ehler E, Evans A, Quarta G, Pantazis A, Saffitz JE, McKenna WJ. Molecular changes in the heart of a severe case of arrhythmogenic right ventricular cardiomyopathy caused by a desmoglein-2 null allele. Cardiovasc Pathol. 2012 Jul-Aug; 21(4):275-82. PMID: 22036071.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  45. Saffitz JE. Arrhythmogenic cardiomyopathy: advances in diagnosis and disease pathogenesis. Circulation. 2011 Oct 11; 124(15):e390-2. PMID: 21986778.
    Citations: 7     Fields:    Translation:HumansCells
  46. Asimaki A, Tandri H, Duffy ER, Winterfield JR, Mackey-Bojack S, Picken MM, Cooper LT, Wilber DJ, Marcus FI, Basso C, Thiene G, Tsatsopoulou A, Protonotarios N, Stevenson WG, McKe