Harvard Catalyst Profiles

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Hiroyuki Inuzuka, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K01AG041218 (INUZUKA, HIROYUKI) Sep 30, 2011 - Dec 31, 2016
    New insights into the role of the Fbw7 tumor suppressor in senescence and aging
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dang F, Nie L, Zhou J, Shimizu K, Chu C, Wu Z, Fassl A, Ke S, Wang Y, Zhang J, Zhang T, Tu Z, Inuzuka H, Sicinski P, Bass AJ, Wei W. Inhibition of CK1e potentiates the therapeutic efficacy of CDK4/6 inhibitor in breast cancer. Nat Commun. 2021 09 10; 12(1):5386. PMID: 34508104.
    Citations:    Fields:    Translation:HumansCells
  2. Dang F, Jiang C, Zhang T, Inuzuka H, Wei W. PCAF and SIRT1 modulate ßTrCP1 protein stability in an acetylation-dependent manner. J Genet Genomics. 2021 07 20; 48(7):652-655. PMID: 34366270.
    Citations:    Fields:    
  3. Gong H, Zhang C, Ogaki T, Inuzuka H, Hashizume D, Miyajima D. Azacalix[3]triazines: A Substructure of Triazine-Based Graphitic Carbon Nitride Featuring Anion-p Interactions. Angew Chem Int Ed Engl. 2021 07 19; 60(30):16377-16381. PMID: 33955147.
    Citations:    Fields:    
  4. Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H. Deficiency of Lipin2 Results in Enhanced NF-?B Signaling and Osteoclast Formation in RAW-D Murine Macrophages. Int J Mol Sci. 2021 Mar 12; 22(6). PMID: 33809261.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG, Liu J, Wei W. Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Res. 2021 Jan; 31(1):104. PMID: 32859994.
    Citations:    Fields:    
  6. Zhang C, Guo Y, He D, Komiya J, Watanabe G, Ogaki T, Wang C, Nihonyanagi A, Inuzuka H, Gong H, Yi Y, Takimiya K, Hashizume D, Miyajima D. A Design Principle for Polar Assemblies with C3 -Sym Bowl-Shaped p-Conjugated Molecules. Angew Chem Int Ed Engl. 2021 Feb 08; 60(6):3261-3267. PMID: 33098203.
    Citations:    Fields:    
  7. Hoshikawa S, Shimizu K, Watahiki A, Chiba M, Saito K, Wei W, Fukumoto S, Inuzuka H. Phosphorylation-dependent osterix degradation negatively regulates osteoblast differentiation. FASEB J. 2020 11; 34(11):14930-14945. PMID: 32931083.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Chiba Y, Yoshizaki K, Saito K, Ikeuchi T, Iwamoto T, Rhodes C, Nakamura T, de Vega S, Morell RJ, Boger ET, Martin D, Hino R, Inuzuka H, Bleck CKE, Yamada A, Yamada Y, Fukumoto S. G protein-coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts. J Biol Chem. 2020 11 06; 295(45):15328-15341. PMID: 32868297.
    Citations: 2     Fields:    Translation:AnimalsCells
  9. Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W. Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy. Nat Cell Biol. 2020 09; 22(9):1064-1075. PMID: 32839551.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  10. Liu J, Peng Y, Shi L, Wan L, Inuzuka H, Long J, Guo J, Zhang J, Yuan M, Zhang S, Wang X, Gao J, Dai X, Furumoto S, Jia L, Pandolfi PP, Asara JM, Kaelin WG, Liu J, Wei W. Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle. Cell Res. 2021 01; 31(1):80-93. PMID: 32669607.
    Citations: 8     Fields:    
  11. Saito K, Michon F, Yamada A, Inuzuka H, Yamaguchi S, Fukumoto E, Yoshizaki K, Nakamura T, Arakaki M, Chiba Y, Ishikawa M, Okano H, Thesleff I, Fukumoto S. Sox21 Regulates Anapc10 Expression and Determines the Fate of Ectodermal Organ. iScience. 2020 Jul 24; 23(7):101329. PMID: 32674056.
    Citations: 3     
  12. Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H. Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Biochem Biophys Res Commun. 2020 04 02; 524(2):477-483. PMID: 32008742.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2019 05; 21(5):662-663. PMID: 30783264.
    Citations: 3     Fields:    
  14. Ma Y, Cui D, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ, Zhao Y. SCFß-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation. Mol Oncol. 2019 02; 13(2):307-321. PMID: 30428154.
    Citations: 5     Fields:    Translation:HumansCells
  15. Huang LY, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y, Wei W. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nat Commun. 2018 09 03; 9(1):3569. PMID: 30177679.
    Citations: 17     Fields:    Translation:HumansCells
  16. Clement E, Inuzuka H, Nihira NT, Wei W, Toker A. Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors. Sci Signal. 2018 03 13; 11(521). PMID: 29535262.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  17. Ci Y, Li X, Chen M, Zhong J, North BJ, Inuzuka H, He X, Li Y, Guo J, Dai X. SCFß-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. Protein Cell. 2018 10; 9(10):879-889. PMID: 29497989.
    Citations: 6     Fields:    Translation:HumansCells
  18. Shimizu K, Nihira NT, Inuzuka H, Wei W. Physiological functions of FBW7 in cancer and metabolism. Cell Signal. 2018 06; 46:15-22. PMID: 29474981.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  19. Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H. NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. Mol Cell. 2017 Nov 16; 68(4):645-658.e5. PMID: 29149593.
    Citations: 12     Fields:    Translation:AnimalsCells
  20. Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nat Med. 2017 Sep; 23(9):1063-1071. PMID: 28805820.
    Citations: 95     Fields:    Translation:HumansCells
  21. Takada M, Zhang W, Suzuki A, Kuroda TS, Yu Z, Inuzuka H, Gao D, Wan L, Zhuang M, Hu L, Zhai B, Fry CJ, Bloom K, Li G, Karpen GH, Wei W, Zhang Q. FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. Cancer Res. 2017 09 15; 77(18):4881-4893. PMID: 28760857.
    Citations: 26     Fields:    Translation:HumansCells
  22. Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W. Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017 02 14; 10(466). PMID: 28196907.
    Citations: 13     Fields:    Translation:HumansCells
  23. Liu L, Michowski W, Inuzuka H, Shimizu K, Nihira NT, Chick JM, Li N, Geng Y, Meng AY, Ordureau A, Kolodziejczyk A, Ligon KL, Bronson RT, Polyak K, Harper JW, Gygi SP, Wei W, Sicinski P. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nat Cell Biol. 2017 03; 19(3):177-188. PMID: 28192421.
    Citations: 38     Fields:    Translation:AnimalsCells
  24. Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017 04; 7(4):424-441. PMID: 28174173.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  25. Nagashima K, Fukushima H, Shimizu K, Yamada A, Hidaka M, Hasumi H, Ikebe T, Fukumoto S, Okabe K, Inuzuka H. Nutrient-induced FNIP degradation by SCFß-TRCP regulates FLCN complex localization and promotes renal cancer progression. Oncotarget. 2017 Feb 07; 8(6):9947-9960. PMID: 28039480.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  26. Takada M, Zhuang M, Inuzuka H, Zhang J, Zurlo G, Zhang J, Zhang Q. EglN2 contributes to triple negative breast tumorigenesis by functioning as a substrate for the FBW7 tumor suppressor. Oncotarget. 2017 Jan 24; 8(4):6787-6795. PMID: 28036276.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  27. Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W. The SCFß-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017 01 03; 10(460). PMID: 28049764.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  28. Guo J, Chakraborty AA, Liu P, Gan W, Zheng X, Inuzuka H, Wang B, Zhang J, Zhang L, Yuan M, Novak J, Cheng JQ, Toker A, Signoretti S, Zhang Q, Asara JM, Kaelin WG, Wei W. pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner. Science. 2016 08 26; 353(6302):929-32. PMID: 27563096.
    Citations: 64     Fields:    Translation:HumansCells
  29. Hong X, Liu W, Song R, Shah JJ, Feng X, Tsang CK, Morgan KM, Bunting SF, Inuzuka H, Zheng XF, Shen Z, Sabaawy HE, Liu L, Pine SR. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016 Oct 14; 44(18):8855-8869. PMID: 27566146.
    Citations: 11     Fields:    Translation:HumansCells
  30. Li X, Dai X, Wan L, Inuzuka H, Sun L, North BJ. Smurf1 regulation of DAB2IP controls cell proliferation and migration. Oncotarget. 2016 May 03; 7(18):26057-69. PMID: 27036023.
    Citations: 11     Fields:    Translation:HumansCells
  31. Wang Z, Dai X, Zhong J, Inuzuka H, Wan L, Li X, Wang L, Ye X, Sun L, Gao D, Zou L, Wei W. SCF(ß-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation. Nat Commun. 2015 Dec 15; 6:10185. PMID: 26666832.
    Citations: 23     Fields:    Translation:HumansCells
  32. Gan W, Dai X, Lunardi A, Li Z, Inuzuka H, Liu P, Varmeh S, Zhang J, Cheng L, Sun Y, Asara JM, Beck AH, Huang J, Pandolfi PP, Wei W. SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. Mol Cell. 2015 Sep 17; 59(6):917-30. PMID: 26344095.
    Citations: 78     Fields:    Translation:HumansCells
  33. Morra F, Luise C, Merolla F, Poser I, Visconti R, Ilardi G, Paladino S, Inuzuka H, Guggino G, Monaco R, Colecchia D, Monaco G, Cerrato A, Chiariello M, Denning K, Claudio PP, Staibano S, Celetti A. FBXW7 and USP7 regulate CCDC6 turnover during the cell cycle and affect cancer drugs susceptibility in NSCLC. Oncotarget. 2015 May 20; 6(14):12697-709. PMID: 25885523.
    Citations: 13     Fields:    Translation:HumansCells
  34. Gasser JA, Inuzuka H, Lau AW, Wei W, Beroukhim R, Toker A. SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer. Mol Cell. 2014 Nov 20; 56(4):595-607. PMID: 25458846.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  35. Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B, Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A, Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC, Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P. Cyclin C is a haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov; 16(11):1080-91. PMID: 25344755.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  36. Dai X, Liu P, Lau AW, Liu Y, Inuzuka H. Acetylation-dependent regulation of essential iPS-inducing factors: a regulatory crossroad for pluripotency and tumorigenesis. Cancer Med. 2014 Oct; 3(5):1211-24. PMID: 25116380.
    Citations: 8     Fields:    Translation:HumansCells
  37. Wu X, Fukushima H, North BJ, Nagaoka Y, Nagashima K, Deng F, Okabe K, Inuzuka H, Wei W. SCFß-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination. Oncotarget. 2014 Jun 30; 5(12):4211-21. PMID: 24961988.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  38. Dai X, North BJ, Inuzuka H. Negative regulation of DAB2IP by Akt and SCFFbw7 pathways. Oncotarget. 2014 May 30; 5(10):3307-15. PMID: 24912918.
    Citations: 15     Fields:    Translation:HumansCells
  39. Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev Cell. 2014 May 27; 29(4):377-91. PMID: 24871945.
    Citations: 53     Fields:    Translation:HumansCells
  40. Lau AW, Liu P, Inuzuka H, Gao D. SIRT1 phosphorylation by AMP-activated protein kinase regulates p53 acetylation. Am J Cancer Res. 2014; 4(3):245-55. PMID: 24959379.
    Citations: 34     
  41. Wang Z, Liu P, Inuzuka H, Wei W. Roles of F-box proteins in cancer. Nat Rev Cancer. 2014 Apr; 14(4):233-47. PMID: 24658274.
    Citations: 177     Fields:    Translation:HumansAnimalsCells
  42. Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24; 508(7497):541-5. PMID: 24670654.
    Citations: 145     Fields:    Translation:AnimalsCells
  43. Liu J, Wan L, Liu P, Inuzuka H, Liu J, Wang Z, Wei W. SCF(ß-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway. Oncotarget. 2014 Feb 28; 5(4):1026-37. PMID: 24657926.
    Citations: 20     Fields:    Translation:HumansCells
  44. Zhong J, Shaik S, Wan L, Tron AE, Wang Z, Sun L, Inuzuka H, Wei W. SCF ß-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget. 2013 Dec; 4(12):2339-53. PMID: 24318128.
    Citations: 30     Fields:    Translation:HumansCells
  45. Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W. Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol. 2013 Nov; 15(11):1340-50. PMID: 24161930.
    Citations: 128     Fields:    Translation:HumansCells
  46. Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep. 2013 Aug 29; 4(4):803-16. PMID: 23972993.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  47. Lau AW, Inuzuka H, Fukushima H, Wan L, Liu P, Gao D, Sun Y, Wei W. Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. Cell Res. 2013 Jul; 23(7):947-61. PMID: 23670162.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  48. Chen H, Ma H, Inuzuka H, Diao J, Lan F, Shi YG, Wei W, Shi Y. DNA damage regulates UHRF1 stability via the SCF(ß-TrCP) E3 ligase. Mol Cell Biol. 2013 Mar; 33(6):1139-48. PMID: 23297342.
    Citations: 28     Fields:    Translation:HumansCells
  49. Wang Z, Wan L, Zhong J, Inuzuka H, Liu P, Sarkar FH, Wei W. Cdc20: a potential novel therapeutic target for cancer treatment. Curr Pharm Des. 2013; 19(18):3210-4. PMID: 23151139.
    Citations: 35     Fields:    Translation:HumansAnimals
  50. Zhong J, Ogura K, Wang Z, Inuzuka H. Degradation of the transcription factor Twist, an oncoprotein that promotes cancer metastasis. Discov Med. 2013 Jan; 15(80):7-15. PMID: 23375009.
    Citations: 29     Fields:    Translation:HumansCells
  51. Wang Z, Inuzuka H, Zhong J, Liu P, Sarkar FH, Sun Y, Wei W. Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2. Oncotarget. 2012 Nov; 3(11):1294-300. PMID: 23230084.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  52. Wang Z, Inuzuka H, Zhong J, Fukushima H, Wan L, Liu P, Wei W. DNA damage-induced activation of ATM promotes ß-TRCP-mediated Mdm2 ubiquitination and destruction. Oncotarget. 2012 Sep; 3(9):1026-35. PMID: 22976441.
    Citations: 18     Fields:    Translation:HumansCells
  53. Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 06; 150(1):179-93. PMID: 22770219.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  54. Shaik S, Nucera C, Inuzuka H, Gao D, Garnaas M, Frechette G, Harris L, Wan L, Fukushima H, Husain A, Nose V, Fadda G, Sadow PM, Goessling W, North T, Lawler J, Wei W. SCF(ß-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 2012 Jul 02; 209(7):1289-307. PMID: 22711876.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  55. Fukushima H, Matsumoto A, Inuzuka H, Zhai B, Lau AW, Wan L, Gao D, Shaik S, Yuan M, Gygi SP, Jimi E, Asara JM, Nakayama K, Nakayama KI, Wei W. SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction. Cell Rep. 2012 May 31; 1(5):434-43. PMID: 22708077.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  56. Min SH, Lau AW, Lee TH, Inuzuka H, Wei S, Huang P, Shaik S, Lee DY, Finn G, Balastik M, Chen CH, Luo M, Tron AE, Decaprio JA, Zhou XZ, Wei W, Lu KP. Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. Mol Cell. 2012 Jun 29; 46(6):771-83. PMID: 22608923.
    Citations: 78     Fields:    Translation:HumansCells
  57. Wang Z, Zhong J, Inuzuka H, Gao D, Shaik S, Sarkar FH, Wei W. An evolving role for DEPTOR in tumor development and progression. Neoplasia. 2012 May; 14(5):368-75. PMID: 22745583.
    Citations: 31     Fields:    Translation:HumansCells
  58. Wang Z, Zhong J, Gao D, Inuzuka H, Liu P, Wei W. DEPTOR ubiquitination and destruction by SCF(ß-TrCP). Am J Physiol Endocrinol Metab. 2012 Jul 15; 303(2):E163-9. PMID: 22454292.
    Citations: 10     Fields:    Translation:HumansCells
  59. Wang Z, Inuzuka H, Zhong J, Wan L, Fukushima H, Sarkar FH, Wei W. Tumor suppressor functions of FBW7 in cancer development and progression. FEBS Lett. 2012 May 21; 586(10):1409-18. PMID: 22673505.
    Citations: 80     Fields:    Translation:HumansAnimals
  60. Wang Z, Fukushima H, Inuzuka H, Wan L, Liu P, Gao D, Sarkar FH, Wei W. Skp2 is a promising therapeutic target in breast cancer. Front Oncol. 2012 Jan 04; 1(57). PMID: 22279619.
    Citations: 38     
  61. Wang Z, Inuzuka H, Fukushima H, Wan L, Gao D, Shaik S, Sarkar FH, Wei W. Emerging roles of the FBW7 tumour suppressor in stem cell differentiation. EMBO Rep. 2011 Dec 23; 13(1):36-43. PMID: 22157894.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  62. Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell. 2011 Dec 09; 44(5):721-33. PMID: 22152476.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  63. Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW, Wei W. mTOR drives its own activation via SCF(ßTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Mol Cell. 2011 Oct 21; 44(2):290-303. PMID: 22017875.
    Citations: 127     Fields:    Translation:HumansCells
  64. Wang Z, Gao D, Fukushima H, Inuzuka H, Liu P, Wan L, Sarkar FH, Wei W. Skp2: a novel potential therapeutic target for prostate cancer. Biochim Biophys Acta. 2012 Jan; 1825(1):11-7. PMID: 21963805.
    Citations: 55     Fields:    Translation:HumansCells
  65. Wang Z, Fukushima H, Gao D, Inuzuka H, Wan L, Lau AW, Liu P, Wei W. The two faces of FBW7 in cancer drug resistance. Bioessays. 2011 Nov; 33(11):851-9. PMID: 22006825.
    Citations: 26     Fields:    Translation:HumansCells
  66. Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 03; 471(7336):104-9. PMID: 21368833.
    Citations: 296     Fields:    Translation:HumansAnimalsCells
  67. Inuzuka H, Fukushima H, Shaik S, Liu P, Lau AW, Wei W. Mcl-1 ubiquitination and destruction. Oncotarget. 2011 Mar; 2(3):239-44. PMID: 21608150.
    Citations: 43     Fields:    Translation:HumansCells
  68. Inuzuka H, Fukushima H, Shaik S, Wei W. Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction. Oncotarget. 2010 Nov; 1(7):685-90. PMID: 21317463.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  69. Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10; 39(5):797-808. PMID: 20832730.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  70. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 09; 18(2):147-59. PMID: 20708156.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  71. Gao D, Inuzuka H, Tseng A, Wei W. Akt finds its new path to regulate cell cycle through modulating Skp2 activity and its destruction by APC/Cdh1. Cell Div. 2009 Jun 23; 4:11. PMID: 19549334.
    Citations: 15     
  72. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell. 2009 Jul; 20(14):3305-16. PMID: 19477924.
    Citations: 39     Fields:    Translation:HumansCells
  73. Gao D, Inuzuka H, Tseng A, Chin RY, Toker A, Wei W. Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction. Nat Cell Biol. 2009 Apr; 11(4):397-408. PMID: 19270695.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  74. Tseng A, Inuzuka H, Gao D, Singh A, Wei W. Experimental approaches to investigate the proteasomal degradation pathways involved in regulation of apoptosis. Methods Enzymol. 2008; 446:205-23. PMID: 18603124.
    Citations:    Fields:    Translation:HumansCells
  75. Paquet M, Asay MJ, Fam SR, Inuzuka H, Castleberry AM, Oller H, Smith Y, Yun CC, Traynelis SF, Hall RA. The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity. J Biol Chem. 2006 Oct 06; 281(40):29949-61. PMID: 16891310.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  76. He J, Bellini M, Inuzuka H, Xu J, Xiong Y, Yang X, Castleberry AM, Hall RA. Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins. J Biol Chem. 2006 Feb 03; 281(5):2820-7. PMID: 16316992.
    Citations: 55     Fields:    Translation:HumansCells
  77. Tokumitsu H, Hatano N, Inuzuka H, Sueyoshi Y, Yokokura S, Ichimura T, Nozaki N, Kobayashi R. Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinases. J Biol Chem. 2005 Oct 21; 280(42):35108-18. PMID: 16105844.
    Citations: 24     Fields:    Translation:AnimalsCells
  78. Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A. LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma. Cancer Res. 2005 Jun 01; 65(11):4587-97. PMID: 15930276.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  79. Murao K, Imachi H, Cao WM, Yu X, Tokumitsu H, Inuzuka H, Wong NC, Shupnik MA, Kobayashi R, Ishida T. Role of calcium-calmodulin-dependent protein kinase cascade in thyrotropin (TSH)-releasing hormone induction of TSH and prolactin gene expression. Endocrinology. 2004 Nov; 145(11):4846-52. PMID: 15308608.
    Citations: 3     Fields:    Translation:AnimalsCells
  80. Tokumitsu H, Hatano N, Inuzuka H, Yokokura S, Nozaki N, Kobayashi R. Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IV. J Biol Chem. 2004 Sep 24; 279(39):40296-302. PMID: 15262966.
    Citations: 14     Fields:    Translation:AnimalsCells
  81. Yu X, Murao K, Sayo Y, Imachi H, Cao WM, Ohtsuka S, Niimi M, Tokumitsu H, Inuzuka H, Wong NC, Kobayashi R, Ishida T. The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression. Diabetes. 2004 Jun; 53(6):1475-81. PMID: 15161751.
    Citations: 13     Fields:    Translation:AnimalsCells
  82. Tokumitsu H, Hatano N, Inuzuka H, Ishikawa Y, Uyeda TQ, Smith JL, Kobayashi R. Regulatory mechanism of Dictyostelium myosin light chain kinase A. J Biol Chem. 2004 Jan 02; 279(1):42-50. PMID: 14570871.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  83. Ishikawa Y, Tokumitsu H, Inuzuka H, Murata-Hori M, Hosoya H, Kobayashi R. Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells. FEBS Lett. 2003 Aug 28; 550(1-3):57-63. PMID: 12935886.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  84. Ohira M, Morohashi A, Inuzuka H, Shishikura T, Kawamoto T, Kageyama H, Nakamura Y, Isogai E, Takayasu H, Sakiyama S, Suzuki Y, Sugano S, Goto T, Sato S, Nakagawara A. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. Oncogene. 2003 Aug 21; 22(35):5525-36. PMID: 12934113.
    Citations: 18     Fields:    Translation:Humans
  85. Tokumitsu H, Inuzuka H, Ishikawa Y, Kobayashi R. A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609. J Biol Chem. 2003 Mar 28; 278(13):10908-13. PMID: 12540834.
    Citations: 20     Fields:    Translation:AnimalsCells
  86. Inuzuka H, Tokumitsu H, Ohkura N, Kobayashi R. Transcriptional regulation of nuclear orphan receptor, NOR-1, by Ca(2+)/calmodulin-dependent protein kinase cascade. FEBS Lett. 2002 Jul 03; 522(1-3):88-92. PMID: 12095624.
    Citations: 2     Fields:    Translation:AnimalsCells
  87. Tokumitsu H, Inuzuka H, Ishikawa Y, Ikeda M, Saji I, Kobayashi R. STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 03; 277(18):15813-8. PMID: 11867640.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  88. Inuzuka H, Yamanouchi K, Tachi C, Tojo H. A transgenic mouse model for investigating the response of the upstream region of whey acidic protein (WAP) gene to various steroid hormones. Exp Anim. 2001 Jan; 50(1):1-7. PMID: 11326419.
    Citations: 1     Fields:    Translation:AnimalsCells
  89. Ohira M, Shishikura T, Kawamoto T, Inuzuka H, Morohashi A, Takayasu H, Kageyama H, Takada N, Takahashi M, Sakiyama S, Suzuki Y, Sugano S, Kuma H, Nozawa I, Nakagawara A. Hunting the subset-specific genes of neuroblastoma: expression profiling and differential screening of the full-length-enriched oligo-capping cDNA libraries. Med Pediatr Oncol. 2000 Dec; 35(6):547-9. PMID: 11107114.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  90. Inuzuka H, Nanbu-Wakao R, Masuho Y, Muramatsu M, Tojo H, Wakao H. Differential regulation of immediate early gene expression in preadipocyte cells through multiple signaling pathways. Biochem Biophys Res Commun. 1999 Nov 30; 265(3):664-8. PMID: 10600478.
    Citations: 17     Fields:    Translation:AnimalsCells
  91. Inuzuka H, Wakao H, Masuho Y, Muramatsu MA, Tojo H, Nanbu-Wakao R. cDNA cloning and expression analysis of mouse zf9, a Krüppel-like transcription factor gene that is induced by adipogenic hormonal stimulation in 3T3-L1 cells. Biochim Biophys Acta. 1999 Oct 28; 1447(2-3):199-207. PMID: 10542316.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  92. Inuzuka H, Yamanouchi K, Tachi C, Tojo H. Expression of milk protein genes is induced directly by exogenous STAT5 without prolactin-mediated signal transduction in transgenic mice. Mol Reprod Dev. 1999 Oct; 54(2):121-5. PMID: 10471471.
    Citations: 1     Fields:    Translation:AnimalsCells
  93. Takeichi M, Inuzuka H, Shimamura K, Fujimori T, Nagafuchi A. Cadherin subclasses: differential expression and their roles in neural morphogenesis. Cold Spring Harb Symp Quant Biol. 1990; 55:319-25. PMID: 2132824.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.