Harvard Catalyst Profiles

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Vinay Subhash Mahajan, Ph.D., M.B.,B.S.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08AI113163 (MAHAJAN, VINAY SUBHASH) Aug 15, 2014 - Jul 31, 2019
    Pathogenesis of IgG4 related disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yonker LM, Gilboa T, Ogata AF, Senussi Y, Lazarovits R, Boribong BP, Bartsch YC, Loiselle M, Rivas MN, Porritt RA, Lima R, Davis JP, Farkas EJ, Burns MD, Young N, Mahajan VS, Hajizadeh S, Lopez XIH, Kreuzer J, Morris R, Martinez EE, Han I, Griswold K, Barry NC, Thompson DB, Church G, Edlow AG, Haas W, Pillai S, Arditi M, Alter G, Walt DR, Fasano A. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier. J Clin Invest. 2021 07 15; 131(14). PMID: 34032635.
    Citations: 11     Fields:    Translation:Humans
  2. Mahajan VS, Mattoo H, Sun N, Viswanadham V, Yuen GJ, Allard-Chamard H, Ahmad M, Murphy SJH, Cariappa A, Tuncay Y, Pillai S. B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers. Nat Commun. 2021 04 13; 12(1):2208. PMID: 33850140.
    Citations:    Fields:    Translation:AnimalsCells
  3. Kaneko N, Boucau J, Kuo HH, Perugino C, Mahajan VS, Farmer JR, Liu H, Diefenbach TJ, Piechocka-Trocha A, Lefteri K, Waring MT, Premo KR, Walker BD, Li JZ, Gaiha G, Yu XG, Lichterfeld M, Padera RF, Pillai S. Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19. medRxiv. 2021 Mar 26. PMID: 33791730.
  4. Allard-Chamard H, Alsufyani F, Kaneko N, Xing K, Perugino C, Mahajan VS, Wheat JL, Deepe GS, Loyd J, Pillai S. CD4+CTLs in Fibrosing Mediastinitis Linked to Histoplasma capsulatum. J Immunol. 2021 02 01; 206(3):524-530. PMID: 33328214.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Alter G, Li JZ, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu XG, Padera RF, Pillai S. Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19. Cell. 2020 10 01; 183(1):143-157.e13. PMID: 32877699.
    Citations: 134     Fields:    Translation:HumansCellsPHPublic Health
  6. Kaneko N, Kuo HH, Boucau J, Farmer JR, Allard-Chamard H, Mahajan VS, Piechocka-Trocha A, Lefteri K, Osborn M, Bals J, Bartsch YC, Bonheur N, Caradonna TM, Chevalier J, Chowdhury F, Diefenbach TJ, Einkauf K, Fallon J, Feldman J, Finn KK, Garcia-Broncano P, Hartana CA, Hauser BM, Jiang C, Kaplonek P, Karpell M, Koscher EC, Lian X, Liu H, Liu J, Ly NL, Michell AR, Rassadkina Y, Seiger K, Sessa L, Shin S, Singh N, Sun W, Sun X, Ticheli HJ, Waring MT, Zhu AL, Li J, Lingwood D, Schmidt AG, Lichterfeld M, Walker BD, Yu X, Padera RF, Pillai S. The Loss of Bcl-6 Expressing T Follicular Helper Cells and the Absence of Germinal Centers in COVID-19. SSRN. 2020 Jul 16; 3652322. PMID: 32742244.
  7. Perugino CA, Kaneko N, Maehara T, Mattoo H, Kers J, Allard-Chamard H, Mahajan VS, Liu H, Della-Torre E, Murphy SJH, Ghebremichael M, Wallace ZS, Bolster MB, Harvey LM, Mylvaganam G, Tuncay Y, Liang L, Montesi SB, Zhang X, Tinju A, Mochizuki K, Munemura R, Sakamoto M, Moriyama M, Nakamura S, Yosef N, Stone JH, Pillai S. CD4+ and CD8+ cytotoxic T lymphocytes may induce mesenchymal cell apoptosis in IgG4-related disease. J Allergy Clin Immunol. 2021 01; 147(1):368-382. PMID: 32485263.
    Citations: 9     Fields:    Translation:HumansCells
  8. Maehara T, Kaneko N, Perugino CA, Mattoo H, Kers J, Allard-Chamard H, Mahajan VS, Liu H, Murphy SJ, Ghebremichael M, Fox D, Payne AS, Lafyatis R, Stone JH, Khanna D, Pillai S. Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis. J Clin Invest. 2020 05 01; 130(5):2451-2464. PMID: 31990684.
    Citations: 24     Fields:    Translation:HumansCells
  9. Mahajan VS, Demissie E, Alsufyani F, Kumari S, Yuen GJ, Viswanadham V, Huang A, Tran JQ, Moon JJ, Irvine DJ, Pillai S. DOCK2 Sets the Threshold for Entry into the Virtual Memory CD8+ T Cell Compartment by Negatively Regulating Tonic TCR Triggering. J Immunol. 2020 01 01; 204(1):49-57. PMID: 31740487.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Farmer JR, Allard-Chamard H, Sun N, Ahmad M, Bertocchi A, Mahajan VS, Aicher T, Arnold J, Benson MD, Morningstar J, Barmettler S, Yuen G, Murphy SJH, Walter JE, Ghebremichael M, Shalek AK, Batista F, Gerszten R, Pillai S. Induction of metabolic quiescence defines the transitional to follicular B cell switch. Sci Signal. 2019 10 22; 12(604). PMID: 31641080.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Allard-Chamard H, Mahajan VS. The Future of Clinical Immunology Laboratory Testing. Clin Lab Med. 2019 12; 39(4):699-708. PMID: 31668279.
    Citations:    Fields:    Translation:HumansCells
  12. Mahajan VS. Update on Clinical Immunology Laboratory Testing. Clin Lab Med. 2019 12; 39(4):xi-xii. PMID: 31668280.
    Citations:    Fields:    Translation:Humans
  13. Farmer JR, Mahajan VS. Molecular Diagnosis of Inherited Immune Disorders. Clin Lab Med. 2019 12; 39(4):685-697. PMID: 31668278.
    Citations: 1     Fields:    Translation:Humans
  14. Della-Torre E, Rigamonti E, Perugino C, Baghai-Sain S, Sun N, Kaneko N, Maehara T, Rovati L, Ponzoni M, Milani R, Lanzillotta M, Mahajan V, Mattoo H, Molineris I, Deshpande V, Stone JH, Falconi M, Manfredi AA, Pillai S. B lymphocytes directly contribute to tissue fibrosis in patients with IgG4-related disease. J Allergy Clin Immunol. 2020 03; 145(3):968-981.e14. PMID: 31319101.
    Citations: 14     Fields:    Translation:HumansCells
  15. Newman JH, Shaver A, Sheehan JH, Mallal S, Stone JH, Pillai S, Bastarache L, Riebau D, Allard-Chamard H, Stone WM, Perugino C, Pilkinton M, Smith SA, McDonnell WJ, Capra JA, Meiler J, Cogan J, Xing K, Mahajan VS, Mattoo H, Hamid R, Phillips JA. IgG4-related disease: Association with a rare gene variant expressed in cytotoxic T cells. Mol Genet Genomic Med. 2019 06; 7(6):e686. PMID: 30993913.
    Citations: 3     Fields:    Translation:HumansCells
  16. Mahajan VS, Alsufyani F, Mattoo H, Rosenberg I, Pillai S. Alterations in sialic-acid O-acetylation glycoforms during murine erythrocyte development. Glycobiology. 2019 03 01; 29(3):222-228. PMID: 30597004.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Perugino CA, AlSalem SB, Mattoo H, Della-Torre E, Mahajan V, Ganesh G, Allard-Chamard H, Wallace Z, Montesi SB, Kreuzer J, Haas W, Stone JH, Pillai S. Identification of galectin-3 as an autoantigen in patients with IgG4-related disease. J Allergy Clin Immunol. 2019 02; 143(2):736-745.e6. PMID: 29852256.
    Citations: 27     Fields:    Translation:HumansCells
  18. Maehara T, Mattoo H, Mahajan VS, Murphy SJ, Yuen GJ, Ishiguro N, Ohta M, Moriyama M, Saeki T, Yamamoto H, Yamauchi M, Daccache J, Kiyoshima T, Nakamura S, Stone JH, Pillai S. The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivo. Life Sci Alliance. 2018 Jan; 1(1). PMID: 29984361.
    Citations: 17     Fields:    
  19. Perugino CA, Mattoo H, Mahajan VS, Maehara T, Wallace ZS, Pillai S, Stone JH. Emerging Treatment Models in Rheumatology: IgG4-Related Disease: Insights Into Human Immunology and Targeted Therapies. Arthritis Rheumatol. 2017 09; 69(9):1722-1732. PMID: 28575535.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  20. Maehara T, Mattoo H, Ohta M, Mahajan VS, Moriyama M, Yamauchi M, Drijvers J, Nakamura S, Stone JH, Pillai SS. Lesional CD4+ IFN-?+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. Ann Rheum Dis. 2017 Feb; 76(2):377-385. PMID: 27358392.
    Citations: 45     Fields:    Translation:HumansCells
  21. Mahajan VS, Demissie E, Mattoo H, Viswanadham V, Varki A, Morris R, Pillai S. Striking Immune Phenotypes in Gene-Targeted Mice Are Driven by a Copy-Number Variant Originating from a Commercially Available C57BL/6 Strain. Cell Rep. 2016 05 31; 15(9):1901-9. PMID: 27210752.
    Citations: 25     Fields:    Translation:AnimalsCells
  22. Mattoo H, Mahajan VS, Maehara T, Deshpande V, Della-Torre E, Wallace ZS, Kulikova M, Drijvers JM, Daccache J, Carruthers MN, Castelino FV, Stone JR, Stone JH, Pillai S. Clonal expansion of CD4(+) cytotoxic T lymphocytes in patients with IgG4-related disease. J Allergy Clin Immunol. 2016 09; 138(3):825-838. PMID: 26971690.
    Citations: 78     Fields:    Translation:HumansCells
  23. Wallace ZS, Mattoo H, Mahajan VS, Kulikova M, Lu L, Deshpande V, Choi HK, Pillai S, Stone JH. Predictors of disease relapse in IgG4-related disease following rituximab. Rheumatology (Oxford). 2016 Jun; 55(6):1000-8. PMID: 26888853.
    Citations: 39     Fields:    Translation:HumansCells
  24. Mahajan VS, Pillai S. Sialic acids and autoimmune disease. Immunol Rev. 2016 Jan; 269(1):145-61. PMID: 26683151.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  25. Wallace ZS, Deshpande V, Mattoo H, Mahajan VS, Kulikova M, Pillai S, Stone JH. IgG4-Related Disease: Clinical and Laboratory Features in One Hundred Twenty-Five Patients. Arthritis Rheumatol. 2015 Sep; 67(9):2466-75. PMID: 25988916.
    Citations: 122     Fields:    Translation:HumansCells
  26. Della-Torre E, Feeney E, Deshpande V, Mattoo H, Mahajan V, Kulikova M, Wallace ZS, Carruthers M, Chung RT, Pillai S, Stone JH. B-cell depletion attenuates serological biomarkers of fibrosis and myofibroblast activation in IgG4-related disease. Ann Rheum Dis. 2015 Dec; 74(12):2236-43. PMID: 25143523.
    Citations: 28     Fields:    Translation:HumansCells
  27. Wallace ZS, Mattoo H, Carruthers M, Mahajan VS, Della Torre E, Lee H, Kulikova M, Deshpande V, Pillai S, Stone JH. Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations. Ann Rheum Dis. 2015 Jan; 74(1):190-5. PMID: 24817416.
    Citations: 106     Fields:    Translation:HumansCells
  28. Mattoo H, Mahajan VS, Della-Torre E, Sekigami Y, Carruthers M, Wallace ZS, Deshpande V, Stone JH, Pillai S. De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease. J Allergy Clin Immunol. 2014 Sep; 134(3):679-87. PMID: 24815737.
    Citations: 86     Fields:    Translation:HumansCells
  29. Della-Torre E, Mattoo H, Mahajan VS, Deshpande V, Krause D, Song P, Pillai S, Stone JH. IgG4-related midline destructive lesion. Ann Rheum Dis. 2014 Jul; 73(7):1434-6. PMID: 24651619.
    Citations: 13     Fields:    Translation:HumansCells
  30. Ahmad M, Mahajan VS, Mattoo H, Stone JH, Pillai S. Individuals with IgG4-related disease do not have an increased frequency of the K409 variant of IgG4 that compromises Fab-arm exchange. J Rheumatol. 2014 Jan; 41(1):185-7. PMID: 24382929.
    Citations: 2     Fields:    Translation:Humans
  31. Mattoo H, Della-Torre E, Mahajan VS, Stone JH, Pillai S. Circulating Th2 memory cells in IgG4-related disease are restricted to a defined subset of subjects with atopy. Allergy. 2014 Mar; 69(3):399-402. PMID: 24382311.
    Citations: 30     Fields:    Translation:HumansCells
  32. Della Torre E, Mattoo H, Mahajan VS, Carruthers M, Pillai S, Stone JH. Prevalence of atopy, eosinophilia, and IgE elevation in IgG4-related disease. Allergy. 2014 02; 69(2):269-272. PMID: 24266692.
    Citations: 54     Fields:    Translation:Humans
  33. Mahajan VS, Mattoo H, Deshpande V, Pillai SS, Stone JH. IgG4-related disease. Annu Rev Pathol. 2014; 9:315-47. PMID: 24111912.
    Citations: 94     Fields:    Translation:HumansCells
  34. Mahajan VS, Jarolim P. How to interpret elevated cardiac troponin levels. Circulation. 2011 Nov 22; 124(21):2350-4. PMID: 22105197.
    Citations: 69     Fields:    Translation:Humans
  35. Palmer MJ, Mahajan VS, Chen J, Irvine DJ, Lauffenburger DA. Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells. Immunol Cell Biol. 2011 Jul; 89(5):581-94. PMID: 21339767.
    Citations: 33     Fields:    Translation:AnimalsCells
  36. Shen CH, Talay O, Mahajan VS, Leskov IB, Eisen HN, Chen J. Antigen-bearing dendritic cells regulate the diverse pattern of memory CD8 T-cell development in different tissues. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22587-92. PMID: 21149737.
    Citations: 9     Fields:    Translation:AnimalsCells
  37. Mahajan VS, Pace CA, Jarolim P. Interpretation of HIV serologic testing results. Clin Chem. 2010 Oct; 56(10):1523-6. PMID: 20876778.
    Citations: 9     Fields:    Translation:HumansCells
  38. Mahajan VS, Drake A, Chen J. Virus-specific host miRNAs: antiviral defenses or promoters of persistent infection? Trends Immunol. 2009 Jan; 30(1):1-7. PMID: 19059006.
    Citations: 28     Fields:    Translation:HumansAnimals
  39. Palmer MJ, Mahajan VS, Trajman LC, Irvine DJ, Lauffenburger DA, Chen J. Interleukin-7 receptor signaling network: an integrated systems perspective. Cell Mol Immunol. 2008 Apr; 5(2):79-89. PMID: 18445337.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  40. Ge Q, Holler PD, Mahajan VS, Nuygen T, Eisen HN, Chen J. Development of CD4+ T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1822-7. PMID: 16443680.
    Citations: 5     Fields:    Translation:AnimalsCells
  41. Mahajan VS, Leskov IB, Chen JZ. Homeostasis of T cell diversity. Cell Mol Immunol. 2005 Feb; 2(1):1-10. PMID: 16212905.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  42. Seth P, Mahajan VS, Chauhan SS. Transcription of human cathepsin L mRNA species hCATL B from a novel alternative promoter in the first intron of its gene. Gene. 2003 Dec 04; 321:83-91. PMID: 14636995.
    Citations: 5     Fields:    Translation:AnimalsCells
  43. Chhikara P, Mahajan VS, Datta Gupta S, Chauhan SS. Differential activity of cathepsin L in human placenta at two different stages of gestation. Placenta. 2002 Jan; 23(1):59-64. PMID: 11869092.
    Citations: 6     Fields:    Translation:Humans
  44. Mahajan VS, Chauhan SS. The human genome project and its implications. Trop Gastroenterol. 2001 Oct-Dec; 22(4):177-9. PMID: 11963320.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.