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Melissa Leger-Abraham, Ph.D.

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Harvard Medical School, Boston, MAPostdoctoral FellowBiological Chemistry and Molecular Pharmacology
University of Montreal, Montreal, Quebec, CanadaPh.D.Biochemistry
University of Montreal, Montreal, Quebec, CanadaB.Sc.Biochemistry
2017 - 2019
Harvard Catalyst, Program for faculty development and diversity inclusion faculty

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M. Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res. 2018 Apr 20; 46(7):3791-3801. PMID: 29562352.
    View in: PubMed
  2. Sekiyama N, Boeszoermenyi A, Arthanari H, Wagner G, Léger-Abraham M. 1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E. Biomol NMR Assign. 2017 Oct; 11(2):187-191. PMID: 28589219.
    View in: PubMed
  3. Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M. Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4036-45. PMID: 26170285; PMCID: PMC4522750.
  4. Zinoviev A, Léger M, Wagner G, Shapira M. A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways. Nucleic Acids Res. 2011 Oct; 39(19):8404-15. PMID: 21764780; PMCID: PMC3201875.
  5. Yoffe Y, Léger M, Zinoviev A, Zuberek J, Darzynkiewicz E, Wagner G, Shapira M. Evolutionary changes in the Leishmania eIF4F complex involve variations in the eIF4E-eIF4G interactions. Nucleic Acids Res. 2009 Jun; 37(10):3243-53. PMID: 19321500; PMCID: PMC2691829.
  6. Léger M, Dulude D, Steinberg SV, Brakier-Gingras L. The three transfer RNAs occupying the A, P and E sites on the ribosome are involved in viral programmed -1 ribosomal frameshift. Nucleic Acids Res. 2007; 35(16):5581-92. PMID: 17704133; PMCID: PMC2018615.
  7. Léger M, Sidani S, Brakier-Gingras L. A reassessment of the response of the bacterial ribosome to the frameshift stimulatory signal of the human immunodeficiency virus type 1. RNA. 2004 Aug; 10(8):1225-35. PMID: 15247429; PMCID: PMC1370612.
  8. Bélanger F, Léger M, Saraiya AA, Cunningham PR, Brakier-Gingras L. Functional studies of the 900 tetraloop capping helix 27 of 16S ribosomal RNA. J Mol Biol. 2002 Jul 26; 320(5):979-89. PMID: 12126619.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.