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profileAmir Tirosh, Ph.D., M.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Endocrine/RFB 2
221 Longwood Ave
Boston MA 02115
Phone617/432-1951
Fax617/732-5764
vCardDownload vCard (login for email)
Other Positions
TitlePostdoctoral Research Fellow
InstitutionHarvard T.H. Chan School of Public Health
DepartmentGenetics and Complex Diseases


Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Twig G, Tirosh A, Leiba A, Levine H, Ben-Ami Shor D, Derazne E, Haklai Z, Goldberger N, Kasher-Meron M, Yifrach D, Gerstein HC, Kark JD. BMI at Age 17 Years and Diabetes Mortality in Midlife: A Nationwide Cohort of 2.3 Million Adolescents. Diabetes Care. 2016 Nov; 39(11):1996-2003. PMID: 27733421.
    View in: PubMed
  2. Twig G, Gerstein HC, Fruchter E, Shina A, Afek A, Derazne E, Tzur D, Cukierman-Yaffe T, Amital D, Amital H, Tirosh A. Self-Perceived Emotional Distress and Diabetes Risk Among Young Men. Am J Prev Med. 2016 Jun; 50(6):737-745. PMID: 26810356.
    View in: PubMed
  3. Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med. 2015 Dec 23; 7(319):319ra205. PMID: 26702093.
    View in: PubMed
  4. Twig G, Shina A, Afek A, Derazne E, Tzur D, Cukierman-Yaffe T, Shechter-Amir D, Gerstein HC, Tirosh A. Sleep quality and risk of diabetes and coronary artery disease among young men. Acta Diabetol. 2016 Apr; 53(2):261-70. PMID: 26077170.
    View in: PubMed
  5. Twig G, Gerstein HC, Ben-Ami Shor D, Derazne E, Tzur D, Afek A, Tirosh A. Coronary artery disease risk among obese metabolically healthy young men. Eur J Endocrinol. 2015 Sep; 173(3):305-12. PMID: 26041076.
    View in: PubMed
  6. Tirosh A, de Souza RJ, Sacks F, Bray GA, Smith SR, LeBoff MS. Sex Differences in the Effects of Weight Loss Diets on Bone Mineral Density and Body Composition: POUNDS LOST Trial. J Clin Endocrinol Metab. 2015 Jun; 100(6):2463-71. PMID: 25825948; PMCID: PMC4454797 [Available on 06/01/16].
  7. Twig G, Afek A, Derazne E, Tzur D, Cukierman-Yaffe T, Gerstein HC, Tirosh A. Diabetes risk among overweight and obese metabolically healthy young adults. Diabetes Care. 2014 Nov; 37(11):2989-95. PMID: 25139886.
    View in: PubMed
  8. Twig G, Gluzman I, Tirosh A, Gerstein HC, Yaniv G, Afek A, Derazne E, Tzur D, Karasik A, Gordon B, Fruchter E, Lubin G, Rudich A, Cukierman-Yaffe T. Cognitive function and the risk for diabetes among young men. Diabetes Care. 2014 Nov; 37(11):2982-8. PMID: 25092683.
    View in: PubMed
  9. Vivante A, Twig G, Tirosh A, Skorecki K, Calderon-Margalit R. Childhood history of resolved glomerular disease and risk of hypertension during adulthood. JAMA. 2014 Mar 19; 311(11):1155-7. PMID: 24643607.
    View in: PubMed
  10. Twig G, Afek A, Shamiss A, Derazne E, Landau Rabbi M, Tzur D, Gordon B, Tirosh A. Adolescence BMI and trends in adulthood mortality: a study of 2.16 million adolescents. J Clin Endocrinol Metab. 2014 Jun; 99(6):2095-103. PMID: 24601695.
    View in: PubMed
  11. Zada G, Tirosh A, Huang AP, Laws ER, Woodmansee WW. The postoperative cortisol stress response following transsphenoidal pituitary surgery: a potential screening method for assessing preserved pituitary function. Pituitary. 2013 Sep; 16(3):319-25. PMID: 22915289.
    View in: PubMed
  12. Tirosh A, Golan R, Harman-Boehm I, Henkin Y, Schwarzfuchs D, Rudich A, Kovsan J, Fiedler GM, Blüher M, Stumvoll M, Thiery J, Stampfer MJ, Shai I. Renal function following three distinct weight loss dietary strategies during 2 years of a randomized controlled trial. Diabetes Care. 2013 Aug; 36(8):2225-32. PMID: 23690533; PMCID: PMC3714527.
  13. Twig G, Livneh A, Vivante A, Afek A, Shamiss A, Derazne E, Tzur D, Ben-Zvi I, Tirosh A, Barchana M, Shohat T, Golan E, Amital H. Mortality risk factors associated with familial Mediterranean fever among a cohort of 1.25 million adolescents. Ann Rheum Dis. 2014 Apr; 73(4):704-9. PMID: 23505237; PMCID: PMC4934385.
  14. Vivante A, Golan E, Tzur D, Leiba A, Tirosh A, Skorecki K, Calderon-Margalit R. Body mass index in 1.2 million adolescents and risk for end-stage renal disease. Arch Intern Med. 2012 Nov 26; 172(21):1644-50. PMID: 23108588; PMCID: PMC4941233.
  15. Twig G, Afek A, Shamiss A, Derazne E, Tzur D, Gordon B, Tirosh A. White blood cell count and the risk for coronary artery disease in young adults. PLoS One. 2012; 7(10):e47183. PMID: 23077568; PMCID: PMC3470580.
  16. Twig G, Afek A, Shamiss A, Derazne E, Tzur D, Gordon B, Tirosh A. White blood cells count and incidence of type 2 diabetes in young men. Diabetes Care. 2013 Feb; 36(2):276-82. PMID: 22961572; PMCID: PMC3554323.
  17. Pereg D, Tirosh A, Elis A, Neuman Y, Mosseri M, Segev D, Lishner M, Hermoni D. Mortality and coronary heart disease in euthyroid patients. Am J Med. 2012 Aug; 125(8):826.e7-12. PMID: 22608790; PMCID: PMC4934377.
  18. Shor R, Tirosh A, Shemesh L, Krakover R, Bar Chaim A, Mor A, Boaz M, Golik A. 25 hydroxyvitamin D levels in patients undergoing coronary artery catheterization. Eur J Intern Med. 2012 Jul; 23(5):470-3. PMID: 22726379.
    View in: PubMed
  19. Golan R, Tirosh A, Schwarzfuchs D, Harman-Boehm I, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Shai I. Dietary intervention induces flow of changes within biomarkers of lipids, inflammation, liver enzymes, and glycemic control. Nutrition. 2012 Feb; 28(2):131-7. PMID: 21820871; PMCID: PMC4935830.
  20. Tirosh A, Shai I, Afek A, Dubnov-Raz G, Ayalon N, Gordon B, Derazne E, Tzur D, Shamis A, Vinker S, Rudich A. Adolescent BMI trajectory and risk of diabetes versus coronary disease. N Engl J Med. 2011 Apr 07; 364(14):1315-25. PMID: 21470009; PMCID: PMC4939259.
  21. Hemi R, Yochananov Y, Barhod E, Kasher-Meron M, Karasik A, Tirosh A, Kanety H. p38 mitogen-activated protein kinase-dependent transactivation of ErbB receptor family: a novel common mechanism for stress-induced IRS-1 serine phosphorylation and insulin resistance. Diabetes. 2011 Apr; 60(4):1134-45. PMID: 21386087; PMCID: PMC3064087.
  22. Ashwal R, Hemi R, Tirosh A, Gordin R, Yissachar E, Cohen-Dayag A, Rosenberg A, Karasik A, Blüher M, Kanety H. Differential expression of novel adiponectin receptor-1 transcripts in skeletal muscle of subjects with normal glucose tolerance and type 2 diabetes. Diabetes. 2011 Mar; 60(3):936-46. PMID: 21289205; PMCID: PMC3046855.
  23. Erez G, Tirosh A, Rudich A, Meiner V, Schwarzfuchs D, Sharon N, Shpitzen S, Blüher M, Stumvoll M, Thiery J, Fiedler GM, Friedlander Y, Leiterstdorf E, Shai I. Phenotypic and genetic variation in leptin as determinants of weight regain. Int J Obes (Lond). 2011 Jun; 35(6):785-792. PMID: 21042325; PMCID: PMC4941231.
  24. Zada G, Tirosh A, Kaiser UB, Laws ER, Woodmansee WW. Cushing's disease and idiopathic intracranial hypertension: case report and review of underlying pathophysiological mechanisms. J Clin Endocrinol Metab. 2010 Nov; 95(11):4850-4. PMID: 20739379.
    View in: PubMed
  25. Tirosh A, Garg R, Adler GK. Mineralocorticoid receptor antagonists and the metabolic syndrome. Curr Hypertens Rep. 2010 Aug; 12(4):252-7. PMID: 20563672; PMCID: PMC2948675.
  26. Tirosh A, Afek A, Rudich A, Percik R, Gordon B, Ayalon N, Derazne E, Tzur D, Gershnabel D, Grossman E, Karasik A, Shamiss A, Shai I. Progression of normotensive adolescents to hypertensive adults: a study of 26,980 teenagers. Hypertension. 2010 Aug; 56(2):203-9. PMID: 20547973.
    View in: PubMed
  27. Farfel A, Tirosh A, Derazne E, Garty BZ, Afek A. Association between socioeconomic status and the prevalence of asthma. Ann Allergy Asthma Immunol. 2010 Jun; 104(6):490-5. PMID: 20568381.
    View in: PubMed
  28. Shai I, Spence JD, Schwarzfuchs D, Henkin Y, Parraga G, Rudich A, Fenster A, Mallett C, Liel-Cohen N, Tirosh A, Bolotin A, Thiery J, Fiedler GM, Blüher M, Stumvoll M, Stampfer MJ. Dietary intervention to reverse carotid atherosclerosis. Circulation. 2010 Mar 16; 121(10):1200-8. PMID: 20194883.
    View in: PubMed
  29. Stern Z, Calderon-Margalit R, Mazar M, Brezis M, Tirosh A. Emergency room visit: a red-flag indicator for poor diabetes care. Diabet Med. 2009 Nov; 26(11):1105-11. PMID: 19929988.
    View in: PubMed
  30. Tirosh A, Shai I, Bitzur R, Kochba I, Tekes-Manova D, Israeli E, Shochat T, Rudich A. Changes in triglyceride levels over time and risk of type 2 diabetes in young men. Diabetes Care. 2008 Oct; 31(10):2032-7. PMID: 18591400; PMCID: PMC2551650.
  31. Elis A, Pereg D, Tirosh A, Shochat T, Tekes-Manova D, Lishner M. Family history of cardiovascular disease does not predict risk-reducing behavior. Eur J Cardiovasc Prev Rehabil. 2008 Jun; 15(3):325-8. PMID: 18525388.
    View in: PubMed
  32. Pereg D, Tirosh A, Lishner M, Goldberg A, Shochat T, Confino-Cohen R. Prevalence of asthma in a large group of Israeli adolescents: influence of country of birth and age at migration. Allergy. 2008 Aug; 63(8):1040-5. PMID: 18384451.
    View in: PubMed
  33. Pereg D, Tirosh A, Shochat T, Hasdai D. Mild renal dysfunction associated with incident coronary artery disease in young males. Eur Heart J. 2008 Jan; 29(2):198-203. PMID: 18079138.
    View in: PubMed
  34. Tirosh A, Rudich A, Shochat T, Tekes-Manova D, Israeli E, Henkin Y, Kochba I, Shai I. Changes in triglyceride levels and risk for coronary heart disease in young men. Ann Intern Med. 2007 Sep 18; 147(6):377-85. PMID: 17876021.
    View in: PubMed
  35. Israeli E, Korzets Z, Tekes-Manova D, Tirosh A, Schochat T, Bernheim J, Golan E. Blood-pressure categories in adolescence predict development of hypertension in accordance with the European guidelines. Am J Hypertens. 2007 Jun; 20(6):705-9. PMID: 17531932.
    View in: PubMed
  36. Heymann AD, Shilo Y, Tirosh A, Valinsky L, Vinker S. Differences between soldiers, with and without emotional distress, in number of primary care medical visits and type of presenting complaints. Isr Med Assoc J. 2007 Feb; 9(2):90-3. PMID: 17348479.
    View in: PubMed
  37. Tirosh A, Mandel D, Mimouni FB, Zimlichman E, Shochat T, Kochba I. Autoimmune diseases in asthma. Ann Intern Med. 2006 Jun 20; 144(12):877-83. PMID: 16785476.
    View in: PubMed
  38. Tirosh A, Shai I, Tekes-Manova D, Israeli E, Pereg D, Shochat T, Kochba I, Rudich A. Normal fasting plasma glucose levels and type 2 diabetes in young men. N Engl J Med. 2005 Oct 06; 353(14):1454-62. PMID: 16207847.
    View in: PubMed
  39. Pereg D, Kimhi O, Tirosh A, Orr N, Kayouf R, Lishner M. The effect of fermented yogurt on the prevention of diarrhea in a healthy adult population. Am J Infect Control. 2005 Mar; 33(2):122-5. PMID: 15761413.
    View in: PubMed
  40. Ben-Romano R, Rudich A, Tirosh A, Potashnik R, Sasaoka T, Riesenberg K, Schlaeffer F, Bashan N. Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta. Diabetologia. 2004 Jun; 47(6):1107-17. PMID: 15168016.
    View in: PubMed
  41. Rudich A, Vanounou S, Riesenberg K, Porat M, Tirosh A, Harman-Boehm I, Greenberg AS, Schlaeffer F, Bashan N. The HIV protease inhibitor nelfinavir induces insulin resistance and increases basal lipolysis in 3T3-L1 adipocytes. Diabetes. 2001 Jun; 50(6):1425-31. PMID: 11375344.
    View in: PubMed
  42. Tirosh A, Rudich A, Potashnik R, Bashan N. Oxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytes. Biochem J. 2001 May 01; 355(Pt 3):757-63. PMID: 11311139; PMCID: PMC1221792.
  43. Talmor D, Applebaum A, Rudich A, Shapira Y, Tirosh A. Activation of mitogen-activated protein kinases in human heart during cardiopulmonary bypass. Circ Res. 2000 May 12; 86(9):1004-7. PMID: 10807874.
    View in: PubMed
  44. Tirosh A, Rudich A, Bashan N. Regulation of glucose transporters--implications for insulin resistance states. J Pediatr Endocrinol Metab. 2000 Feb; 13(2):115-33. PMID: 10711656.
    View in: PubMed
  45. Rudich A, Tirosh A, Potashnik R, Khamaisi M, Bashan N. Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes. Diabetologia. 1999 Aug; 42(8):949-57. PMID: 10491755.
    View in: PubMed
  46. Tirosh A, Potashnik R, Bashan N, Rudich A. Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation. J Biol Chem. 1999 Apr 09; 274(15):10595-602. PMID: 10187855.
    View in: PubMed
  47. Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes. 1998 Oct; 47(10):1562-9. PMID: 9753293.
    View in: PubMed
  48. Khamaisi M, Potashnik R, Tirosh A, Demshchak E, Rudich A, Tritschler H, Wessel K, Bashan N. Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats. Metabolism. 1997 Jul; 46(7):763-8. PMID: 9225829.
    View in: PubMed
  49. Tirosh A, Anaise JZ. Prevalence of caries and periodontal disease and oral hygiene status in urban teenagers (15--17 years of age). Refuat Hapeh Vehashinayim. 1979 Jan; 28(1):39-44, 35-9. PMID: 289638.
    View in: PubMed
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