Harvard Catalyst Profiles

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Odile Daniele Peroni, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhou P, Santoro A, Peroni OD, Nelson AT, Saghatelian A, Siegel D, Kahn BB. PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms. J Clin Invest. 2019 10 01; 129(10):4138-4150. PMID: 31449056.
    Citations: 21     Fields:    Translation:AnimalsCells
  2. Syed I, Lee J, Peroni OD, Yore MM, Moraes-Vieira PM, Santoro A, Wellenstein K, Smith U, McGraw TE, Saghatelian A, Kahn BB. Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects. Cell Metab. 2018 10 02; 28(4):543-546. PMID: 30244974.
    Citations: 12     Fields:    Translation:Animals
  3. Syed I, Lee J, Moraes-Vieira PM, Donaldson CJ, Sontheimer A, Aryal P, Wellenstein K, Kolar MJ, Nelson AT, Siegel D, Mokrosinski J, Farooqi IS, Zhao JJ, Yore MM, Peroni OD, Saghatelian A, Kahn BB. Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab. 2018 02 06; 27(2):419-427.e4. PMID: 29414687.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  4. Vijayakumar A, Aryal P, Wen J, Syed I, Vazirani RP, Moraes-Vieira PM, Camporez JP, Gallop MR, Perry RJ, Peroni OD, Shulman GI, Saghatelian A, McGraw TE, Kahn BB. Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport. Cell Rep. 2017 Oct 24; 21(4):1021-1035. PMID: 29069585.
    Citations: 46     Fields:    Translation:AnimalsCells
  5. Kolar MJ, Kamat SS, Parsons WH, Homan EA, Maher T, Peroni OD, Syed I, Fjeld K, Molven A, Kahn BB, Cravatt BF, Saghatelian A. Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase. Biochemistry. 2016 08 23; 55(33):4636-41. PMID: 27509211.
    Citations: 24     Fields:    
  6. Moraes-Vieira PM, Castoldi A, Aryal P, Wellenstein K, Peroni OD, Kahn BB. Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance. Diabetes. 2016 05; 65(5):1317-27. PMID: 26936962.
    Citations: 17     Fields:    Translation:AnimalsCells
  7. Zemany L, Bhanot S, Peroni OD, Murray SF, Moraes-Vieira PM, Castoldi A, Manchem P, Guo S, Monia BP, Kahn BB. Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice. Diabetes. 2015 May; 64(5):1603-14. PMID: 25524914.
    Citations: 25     Fields:    Translation:Animals
  8. Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, Patel RT, Lee J, Chen S, Peroni OD, Dhaneshwar AS, Hammarstedt A, Smith U, McGraw TE, Saghatelian A, Kahn BB. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell. 2014 Oct 09; 159(2):318-32. PMID: 25303528.
    Citations: 250     Fields:    Translation:HumansAnimalsCells
  9. Chiappini F, Catalano KJ, Lee J, Peroni OD, Lynch J, Dhaneshwar AS, Wellenstein K, Sontheimer A, Neel BG, Kahn BB. Ventromedial hypothalamus-specific Ptpn1 deletion exacerbates diet-induced obesity in female mice. J Clin Invest. 2014 Sep; 124(9):3781-92. PMID: 25083988.
    Citations: 14     Fields:    Translation:Animals
  10. Kraus D, Yang Q, Kong D, Banks AS, Zhang L, Rodgers JT, Pirinen E, Pulinilkunnil TC, Gong F, Wang YC, Cen Y, Sauve AA, Asara JM, Peroni OD, Monia BP, Bhanot S, Alhonen L, Puigserver P, Kahn BB. Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature. 2014 Apr 10; 508(7495):258-62. PMID: 24717514.
    Citations: 179     Fields:    Translation:AnimalsCells
  11. Zemany L, Kraus BJ, Norseen J, Saito T, Peroni OD, Johnson RL, Kahn BB. Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol. 2014 Mar; 34(6):1170-86. PMID: 24421389.
    Citations: 15     Fields:    Translation:AnimalsCells
  12. Kawashima J, Alquier T, Tsuji Y, Peroni OD, Kahn BB. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One. 2012; 7(5):e36335. PMID: 22590531.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Herman MA, Peroni OD, Villoria J, Schön MR, Abumrad NA, Blüher M, Klein S, Kahn BB. A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. Nature. 2012 Apr 19; 484(7394):333-8. PMID: 22466288.
    Citations: 249     Fields:    Translation:HumansAnimalsCells
  14. Pulinilkunnil T, He H, Kong D, Asakura K, Peroni OD, Lee A, Kahn BB. Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem. 2011 Mar 18; 286(11):8798-809. PMID: 21209093.
    Citations: 47     Fields:    Translation:AnimalsCells
  15. Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB. Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. J Biol Chem. 2010 Apr 09; 285(15):11348-56. PMID: 20093359.
    Citations: 145     Fields:    Translation:Animals
  16. Preitner F, Mody N, Graham TE, Peroni OD, Kahn BB. Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis. Am J Physiol Endocrinol Metab. 2009 Dec; 297(6):E1420-9. PMID: 19826103.
    Citations: 53     Fields:    Translation:Animals
  17. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7. PMID: 17643114.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  18. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell Metab. 2007 Apr; 5(4):305-12. PMID: 17403374.
    Citations: 115     Fields:    Translation:AnimalsCells
  19. Beylot M, Pinteur C, Peroni O. Expression of the adiponectin receptors AdipoR1 and AdipoR2 in lean rats and in obese Zucker rats. Metabolism. 2006 Mar; 55(3):396-401. PMID: 16483885.
    Citations: 10     Fields:    Translation:Animals
  20. Kershaw EE, Hamm JK, Verhagen LA, Peroni O, Katic M, Flier JS. Adipose triglyceride lipase: function, regulation by insulin, and comparison with adiponutrin. Diabetes. 2006 Jan; 55(1):148-57. PMID: 16380488.
    Citations: 132     Fields:    Translation:AnimalsCells
  21. Letexier D, Peroni O, Pinteur C, Beylot M. In vivo expression of carbohydrate responsive element binding protein in lean and obese rats. Diabetes Metab. 2005 Dec; 31(6):558-66. PMID: 16357804.
    Citations: 4     Fields:    Translation:Animals
  22. Kim YB, Peroni OD, Aschenbach WG, Minokoshi Y, Kotani K, Zisman A, Kahn CR, Goodyear LJ, Kahn BB. Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism. Mol Cell Biol. 2005 Nov; 25(21):9713-23. PMID: 16227617.
    Citations: 22     Fields:    Translation:AnimalsCells
  23. Yang Q, Graham TE, Mody N, Preitner F, Peroni OD, Zabolotny JM, Kotani K, Quadro L, Kahn BB. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005 Jul 21; 436(7049):356-62. PMID: 16034410.
    Citations: 705     Fields:    Translation:AnimalsCells
  24. Carvalho E, Kotani K, Peroni OD, Kahn BB. Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle. Am J Physiol Endocrinol Metab. 2005 Oct; 289(4):E551-61. PMID: 15928024.
    Citations: 83     Fields:    Translation:Animals
  25. Kotani K, Peroni OD, Minokoshi Y, Boss O, Kahn BB. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J Clin Invest. 2004 Dec; 114(11):1666-75. PMID: 15578099.
    Citations: 49     Fields:    Translation:HumansAnimals
  26. Large V, Peroni O, Letexier D, Ray H, Beylot M. Metabolism of lipids in human white adipocyte. Diabetes Metab. 2004 09; 30(4):294-309. PMID: 15525872.
    Citations: 71     Fields:    Translation:HumansCells
  27. Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004 Jun; 24(11):5080-7. PMID: 15143198.
    Citations: 47     Fields:    Translation:Animals
  28. Carvalho E, Schellhorn SE, Zabolotny JM, Martin S, Tozzo E, Peroni OD, Houseknecht KL, Mundt A, James DE, Kahn BB. GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase. J Biol Chem. 2004 May 14; 279(20):21598-605. PMID: 14985357.
    Citations: 26     Fields:    Translation:AnimalsCells
  29. Blüher M, Michael MD, Peroni OD, Ueki K, Carter N, Kahn BB, Kahn CR. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell. 2002 Jul; 3(1):25-38. PMID: 12110165.
    Citations: 271     Fields:    Translation:AnimalsCells
  30. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature. 2002 Jan 17; 415(6869):339-43. PMID: 11797013.
    Citations: 543     Fields:    Translation:AnimalsCells
  31. Kim JK, Zisman A, Fillmore JJ, Peroni OD, Kotani K, Perret P, Zong H, Dong J, Kahn CR, Kahn BB, Shulman GI. Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4. J Clin Invest. 2001 Jul; 108(1):153-60. PMID: 11435467.
    Citations: 71     Fields:    Translation:Animals
  32. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell. 2001 Jun 15; 105(6):745-55. PMID: 11440717.
    Citations: 281     Fields:    Translation:HumansAnimals
  33. Vidon C, Boucher P, Cachefo A, Peroni O, Diraison F, Beylot M. Effects of isoenergetic high-carbohydrate compared with high-fat diets on human cholesterol synthesis and expression of key regulatory genes of cholesterol metabolism. Am J Clin Nutr. 2001 May; 73(5):878-84. PMID: 11333840.
    Citations: 8     Fields:    Translation:HumansCellsCTClinical Trials
  34. Zabolotny JM, Kim YB, Peroni OD, Kim JK, Pani MA, Boss O, Klaman LD, Kamatkar S, Shulman GI, Kahn BB, Neel BG. Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5187-92. PMID: 11309481.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  35. Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature. 2001 Feb 08; 409(6821):729-33. PMID: 11217863.
    Citations: 385     Fields:    Translation:AnimalsCells
  36. Zisman A, Peroni OD, Abel ED, Michael MD, Mauvais-Jarvis F, Lowell BB, Wojtaszewski JF, Hirshman MF, Virkamaki A, Goodyear LJ, Kahn CR, Kahn BB. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med. 2000 Aug; 6(8):924-8. PMID: 10932232.
    Citations: 234     Fields:    Translation:HumansAnimalsCells
  37. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Stricker-Krongrad A, Shulman GI, Neel BG, Kahn BB. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol. 2000 Aug; 20(15):5479-89. PMID: 10891488.
    Citations: 334     Fields:    Translation:Animals
  38. Kim JK, Michael MD, Previs SF, Peroni OD, Mauvais-Jarvis F, Neschen S, Kahn BB, Kahn CR, Shulman GI. Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest. 2000 Jun; 105(12):1791-7. PMID: 10862794.
    Citations: 115     Fields:    Translation:AnimalsCells
  39. Kim YB, Peroni OD, Franke TF, Kahn BB. Divergent regulation of Akt1 and Akt2 isoforms in insulin target tissues of obese Zucker rats. Diabetes. 2000 May; 49(5):847-56. PMID: 10905496.
    Citations: 32     Fields:    Translation:AnimalsCells
  40. Saadatian M, Peroni O, Diraison F, Beylot M. In vivo measurement of gluconeogenesis in animals and humans with deuterated water: a simplified method. Diabetes Metab. 2000 May; 26(3):202-9. PMID: 10880894.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  41. Boss O, Bachman E, Vidal-Puig A, Zhang CY, Peroni O, Lowell BB. Role of the beta(3)-adrenergic receptor and/or a putative beta(4)-adrenergic receptor on the expression of uncoupling proteins and peroxisome proliferator-activated receptor-gamma coactivator-1. Biochem Biophys Res Commun. 1999 Aug 11; 261(3):870-6. PMID: 10441518.
    Citations: 23     Fields:    Translation:Animals
  42. Peroni O, Large V, Diraison F, Beylot M. Glucose production and gluconeogenesis in postabsorptive and starved normal and streptozotocin-diabetic rats. Metabolism. 1997 Nov; 46(11):1358-63. PMID: 9361699.
    Citations: 4     Fields:    Translation:AnimalsCells
  43. Beylot M, Peroni O, Diraison F, Large V. In vivo studies of intrahepatic metabolic pathways. Diabetes Metab. 1997 Jun; 23(3):251-7. PMID: 9234004.
    Citations:    Fields:    Translation:Humans
  44. Peroni O, Large V, Odeon M, Beylot M. Measuring glycerol turnover, gluconeogenesis from glycerol, and total gluconeogenesis with [2-13C] glycerol: role of the infusion-sampling mode. Metabolism. 1996 Jul; 45(7):897-901. PMID: 8692028.
    Citations: 4     Fields:    Translation:AnimalsCells
  45. Beylot M, Peroni O, Diraison F, Large V. New methods for in vivo studies of hepatic metabolism. Reprod Nutr Dev. 1996; 36(4):363-73. PMID: 8878354.
    Citations:    Fields:    Translation:HumansCells
  46. Peroni O, Large V, Beylot M. Measuring gluconeogenesis with [2-13C]glycerol and mass isotopomer distribution analysis of glucose. Am J Physiol. 1995 Sep; 269(3 Pt 1):E516-23. PMID: 7573429.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.