Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Kathryn D. Held, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R21CA182259 (HELD, KATHRYN DALE) Dec 1, 2013 - Nov 30, 2015
    NIH
    Radiobiology Investigations of Ions Heavier than Protons
    Role: Principal Investigator
  2. RC1AI081282 (HELD, KATHRYN DALE) Sep 25, 2009 - Jan 31, 2013
    NIH
    Novel agents for mitigation of radiation-induced pulmonary injury
    Role: Co-Principal Investigator
  3. R13CA141926 (WOLOSCHAK, GAYLE E.) Sep 1, 2009 - Aug 31, 2015
    NIH
    Radiation Research Society Annual Meeting
    Role: Co-Principal Investigator
  4. P01CA095227 (HELD, KATHRYN DALE) Sep 1, 2004 - Jul 31, 2010
    NIH
    Cellular Responses to Localized Oxidative Stress
    Role: Principal Investigator
  5. R13CA106951 (HELD, KATHRYN DALE) May 1, 2004 - Apr 30, 2005
    NIH
    Eighth International Workshop on Radiation Damage to DNA
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hermann AL, Fell GL, Kemény LV, Fung CY, Held KD, Biggs PJ, Rivera PD, Bilbo SD, Igras V, Willers H, Kung J, Gheorghiu L, Hideghéty K, Mao J, Woolf CJ, Fisher DE. ß-Endorphin mediates radiation therapy fatigue. Sci Adv. 2022 Dec 16; 8(50):eabn6025. PMID: 36525492; PMCID: PMC9757747.
    Citations:    Fields:    
  2. Peter JS, Schuemann J, Held KD, McNamara AL. Nano-scale simulation of neuronal damage by galactic cosmic rays. Phys Med Biol. 2022 11 25; 67(23). PMID: 36172820; PMCID: PMC9951267.
    Citations:    Fields:    Translation:Cells
  3. Linet MS, Applegate KE, McCollough CH, Bailey JE, Bright C, Bushberg JT, Chanock SJ, Coleman J, Dalal NH, Dauer LT, Davis PB, Eagar RY, Frija G, Held KD, Kachnic LA, Kiess AP, Klein LW, Kosti O, Miller CW, Miller-Thomas MM, Straus C, Vapiwala N, Wieder JS, Yoo DC, Brink JA, Dalrymple JL. A Multimedia Strategy to Integrate Introductory Broad-Based Radiation Science Education in US Medical Schools. J Am Coll Radiol. 2023 02; 20(2):251-264. PMID: 36130692.
    Citations:    Fields:    Translation:Humans
  4. Nogueira-Pedro A, Segreto HRC, Held KD, Ferreira Junior AFG, Dias CC, Hastreiter AA, Makiyama EN, Paredes-Gamero EJ, Borelli P, Fock RA. Direct ionizing radiation and bystander effect in mouse mesenchymal stem cells. Int J Radiat Biol. 2022 Apr 22; 1-11. PMID: 35394402.
    Citations:    Fields:    
  5. Uda Y, Saini V, Petty CA, Alshehri M, Shi C, Spatz JM, Santos R, Newell CM, Huang TY, Kochen A, Kim JW, Constantinou CK, Saito H, Held KD, Hesse E, Pajevic PD. Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss. Aging (Albany NY). 2021 12 30; 13(24):25607-25642. PMID: 34968192; PMCID: PMC8751595.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Boice JD, Quinn B, Al-Nabulsi I, Ansari A, Blake PK, Blattnig SR, Caffrey EA, Cohen SS, Golden AP, Held KD, Jokisch DW, Leggett RW, Mumma MT, Samuels C, Till JE, Tolmachev SY, Yoder RC, Zhou JY, Dauer LT. A million persons, a million dreams: a vision for a national center of radiation epidemiology and biology. Int J Radiat Biol. 2022; 98(4):795-821. PMID: 34669549.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  7. Preston RJ, Rühm W, Azzam EI, Boice JD, Bouffler S, Held KD, Little MP, Shore RE, Shuryak I, Weil MM. Adverse outcome pathways, key events, and radiation risk assessment. Int J Radiat Biol. 2021; 97(6):804-814. PMID: 33211576.
    Citations: 3     Fields:    Translation:Humans
  8. Prasanna PG, Woloschak GE, DiCarlo AL, Buchsbaum JC, Schaue D, Chakravarti A, Cucinotta FA, Formenti SC, Guha C, Hu DJ, Khan MK, Kirsch DG, Krishnan S, Leitner WW, Marples B, McBride W, Mehta MP, Rafii S, Sharon E, Sullivan JM, Weichselbaum RR, Ahmed MM, Vikram B, Coleman CN, Held KD. Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks? Radiat Res. 2020 11 10; 194(5):452-464. PMID: 33045077; PMCID: PMC8009137.
    Citations: 18     Fields:    Translation:HumansAnimalsPHPublic Health
  9. Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio. Radiat Res. 2020 07 08; 194(1):9-21. PMID: 32401689; PMCID: PMC7484135.
    Citations: 9     Fields:    Translation:HumansCells
  10. Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio. Phys Med Biol. 2020 04 23; 65(8):085015. PMID: 32101803.
    Citations: 12     Fields:    Translation:Cells
  11. Held KD, Lomax AJ, Troost EGC. Proton therapy special feature: introductory editorial. Br J Radiol. 2020 Mar; 93(1107):20209004. PMID: 32081045; PMCID: PMC7066953.
    Citations: 4     Fields:    Translation:Humans
  12. Guardiola C, De Marzi L, Prezado Y. Verification of a Monte Carlo dose calculation engine in proton minibeam radiotherapy in a passive scattering beamline for preclinical trials. Br J Radiol. 2020 Mar; 93(1107):20190578. PMID: 31868523; PMCID: PMC7066976.
    Citations: 5     Fields:    Translation:AnimalsPHPublic Health
  13. Müller M, Espinoza S, Jüstel T, Held KD, Anderson RR, Purschke M. UVC-Emitting LuPO4:Pr3+ Nanoparticles Decrease Radiation Resistance of Hypoxic Cancer Cells. Radiat Res. 2020 01; 193(1):82-87. PMID: 31738663.
    Citations: 1     Fields:    Translation:HumansCells
  14. Puspitasari A, Yamazaki H, Kawamura H, Nakano T, Takahashi A, Shirao T, Held KD. X-irradiation of developing hippocampal neurons causes changes in neuron population phenotypes, dendritic morphology and synaptic protein expression in surviving neurons at maturity. Neurosci Res. 2020 Nov; 160:11-24. PMID: 31711782.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Kakoti S, Yamauchi M, Gu W, Kato R, Yasuhara T, Hagiwara Y, Laskar S, Oike T, Sato H, Held KD, Nakano T, Shibata A. p53 deficiency augments nucleolar instability after ionizing irradiation. Oncol Rep. 2019 Dec; 42(6):2293-2302. PMID: 31578593; PMCID: PMC6826308.
    Citations: 1     Fields:    Translation:HumansCells
  16. Wang Y, Ferrer-Espada R, Baglo Y, Goh XS, Held KD, Grad YH, Gu Y, Gelfand JA, Dai T. Photoinactivation of Neisseria gonorrhoeae: A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection. J Infect Dis. 2019 07 31; 220(5):873-881. PMID: 30629196; PMCID: PMC6667797.
    Citations: 12     Fields:    Translation:HumansCells
  17. Boice JD, Held KD, Shore RE. Radiation epidemiology and health effects following low-level radiation exposure. J Radiol Prot. 2019 Jul 04; 39(4):S14-S27. PMID: 31272090.
    Citations: 7     Fields:    
  18. Paganetti H, Blakely E, Carabe-Fernandez A, Carlson DJ, Das IJ, Dong L, Grosshans D, Held KD, Mohan R, Moiseenko V, Niemierko A, Stewart RD, Willers H. Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy. Med Phys. 2019 Mar; 46(3):e53-e78. PMID: 30661238; PMCID: PMC9559855.
    Citations: 54     Fields:    Translation:Humans
  19. Permata TBM, Hagiwara Y, Sato H, Yasuhara T, Oike T, Gondhowiardjo S, Held KD, Nakano T, Shibata A. Base excision repair regulates PD-L1 expression in cancer cells. Oncogene. 2019 06; 38(23):4452-4466. PMID: 30755733.
    Citations: 36     Fields:    Translation:HumansCells
  20. Held K. NCRP 54th Annual Meeting, Radiation Protection Responsibility in Medicine: Tenforde Topical Lecture and Fostering Innovations Q & A (Questions for Roy E. Shore [T.S. Tenforde Lecturer], Ehsan Samei, Keith J. Strauss, and X. George Xu). Health Phys. 2019 02; 116(2):276-278. PMID: 30585975.
    Citations:    Fields:    Translation:Humans
  21. Held K. NCRP 54th Annual Meeting, Radiation Protection Responsibility in Medicine: Nuclear Medicine and Radiation Oncology Q&A (Questions for Frederic H. Fahey, Melissa C. Martin, George sgouros, and Bruce Thomadsen). Health Phys. 2019 Feb; 116(2):205-206. PMID: 30585964.
    Citations:    Fields:    Translation:Humans
  22. Held K. NCRP 54th Annual Meeting, Radiation Protection Responsibility in Medicine: Dose, Benefit, Risk, and Safety Q & A (Questions for Jerrold T. Bushberg, Mythreyi Chatfield, Fred A. Mettler, Jr., Marvin Rosenstein, and Pat B. Zanzonico). Health Phys. 2019 02; 116(2):143-147. PMID: 30585955.
    Citations:    Fields:    Translation:HumansPHPublic Health
  23. Held K. NCRP 54th Annual Meeting, Radiation Protection Responsibility in Medicine: Diagnostic X-ray Imaging Session Q & A (Questions for Alan G. Lurie, Cynthia H. McCollough, and J. Anthony Seibert). Health Phys. 2019 Feb; 116(2):170-174. PMID: 30585959.
    Citations:    Fields:    Translation:Humans
  24. Held K. NCRP 54th Annual Meeting, Radiation Protection Responsibility in Medicine: Dialogue and Shared Decision Making Q&A (Questions for Kimberly E. Applegate, Lawrence T. Dauer, Randall N. Hyer, María Del Rosario Pérez, Julie E.K. Timins, and Jessica S. Wieder). Health Phys. 2019 Feb; 116(2):214-217. PMID: 30585967.
    Citations:    Fields:    Translation:HumansPHPublic Health
  25. Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B. TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiat Res. 2019 02; 191(2):125-138. PMID: 30609382; PMCID: PMC6377808.
    Citations: 47     Fields:    Translation:HumansCells
  26. Hagiwara Y, Oike T, Niimi A, Yamauchi M, Sato H, Limsirichaikul S, Held KD, Nakano T, Shibata A. Clustered DNA double-strand break formation and the repair pathway following heavy-ion irradiation. J Radiat Res. 2019 Jan 01; 60(1):69-79. PMID: 30476166; PMCID: PMC6373698.
    Citations: 25     Fields:    Translation:HumansCells
  27. Hada M, Ikeda H, Rhone JR, Beitman AJ, Plante I, Souda H, Yoshida Y, Held KD, Fujiwara K, Saganti PB, Takahashi A. Increased Chromosome Aberrations in Cells Exposed Simultaneously to Simulated Microgravity and Radiation. Int J Mol Sci. 2018 Dec 22; 20(1). PMID: 30583489; PMCID: PMC6337712.
    Citations: 17     Fields:    Translation:HumansCells
  28. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. A New Standard DNA Damage (SDD) Data Format. Radiat Res. 2019 01; 191(1):76-92. PMID: 30407901; PMCID: PMC6407706.
    Citations: 22     Fields:    Translation:Cells
  29. McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J. Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 09 06; 63(17):175018. PMID: 30088810.
    Citations: 18     Fields:    Translation:Humans
  30. Müller M, Wang Y, Squillante MR, Held KD, Anderson RR, Purschke M. UV scintillating particles as radiosensitizer enhance cell killing after X-ray excitation. Radiother Oncol. 2018 12; 129(3):589-594. PMID: 30539764; PMCID: PMC6340643.
    Citations: 3     Fields:    Translation:HumansCells
  31. Mohan R, Held KD, Story MD, Grosshans D, Capala J. Proceedings of the National Cancer Institute Workshop on Charged Particle Radiobiology. Int J Radiat Oncol Biol Phys. 2018 03 15; 100(4):816-831. PMID: 29485053.
    Citations: 7     Fields:    Translation:Humans
  32. Hagiwara Y, Niimi A, Isono M, Yamauchi M, Yasuhara T, Limsirichaikul S, Oike T, Sato H, Held KD, Nakano T, Shibata A. 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread ?H2AX foci after high LET heavy-ion particle radiation. Oncotarget. 2017 Dec 12; 8(65):109370-109381. PMID: 29312614.
    Citations: 23     Fields:    
  33. Sato H, Niimi A, Yasuhara T, Permata TBM, Hagiwara Y, Isono M, Nuryadi E, Sekine R, Oike T, Kakoti S, Yoshimoto Y, Held KD, Suzuki Y, Kono K, Miyagawa K, Nakano T, Shibata A. DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. Nat Commun. 2017 11 24; 8(1):1751. PMID: 29170499; PMCID: PMC5701012.
    Citations: 259     Fields:    Translation:HumansCells
  34. Held KD, Hamada N. Correction to: Held and Hamada, Summary of the Bill Morgan Memorial Symposium - part 1: biology, epidemiology and radiation protection. Int J Radiat Biol. 2017 10; 93(10):x. PMID: 28766988.
    Citations:    Fields:    
  35. Hamada N, Salomaa S, Held KD, Boice JD. Introduction to the Bill Morgan Memorial Special Issue on Biology, Epidemiology, and Implications for Radiation Protection. Int J Radiat Biol. 2017 10; 93(10):1003-1008. PMID: 28612672.
    Citations:    Fields:    Translation:HumansPHPublic Health
  36. Held KD, Hamada N. Summary of the Bill Morgan Memorial Symposium - part 1: biology, epidemiology and radiation protection. Int J Radiat Biol. 2017 10; 93(10):1054-1055. PMID: 28635554.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  37. Hausoel A, Karolak M, Sas?oglu E, Lichtenstein A, Held K, Katanin A, Toschi A, Sangiovanni G. Local magnetic moments in iron and nickel at ambient and Earth's core conditions. Nat Commun. 2017 07 12; 8:16062. PMID: 28799538.
    Citations: 3     Fields:    
  38. Held K. NCRP 52nd Annual Meeting, Meeting the Needs of the Nation for Radiation Protection: How Did We Get Here? Session Q&A (Session Chairs Kathryn H. Pryor and Richard E. Toohey). Health Phys. 2017 02; 112(2):152-159. PMID: 28027154.
    Citations:    Fields:    Translation:Humans
  39. Ikeda H, Souda H, Puspitasari A, Held KD, Hidema J, Nikawa T, Yoshida Y, Kanai T, Takahashi A. Development and performance evaluation of a three-dimensional clinostat synchronized heavy-ion irradiation system. Life Sci Space Res (Amst). 2017 Feb; 12:51-60. PMID: 28212708.
    Citations: 12     Fields:    Translation:HumansCells
  40. McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J. Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215. PMID: 28017738.
    Citations: 25     Fields:    Translation:Cells
  41. Lin Y, Tessa C, Rusek A, McMahon S, Kaminuma T, Held K. SU-C-204-04: Irradiation of Human Cell Lines Using Various Ions. Med Phys. 2016 Jun; 43(6):3314. PMID: 28047192.
    Citations:    
  42. Held K. WE-FG-BRB-04: RBEs for Human Lung Cancer Cells Exposed to Protons and Heavier Ions: Implications for Clinical Use of Charged Particles in Cancer Therapy. Med Phys. 2016 Jun; 43(6):3822-3823. PMID: 28046299.
    Citations:    
  43. McNamara A, Perl J, Piersimoni P, Ramos-Mendez J, Faddegon B, Held K, Paganetti H, Schuemann J. WE-H-BRA-04: Biological Geometries for the Monte Carlo Simulation Toolkit TOPASNBio. Med Phys. 2016 Jun; 43(6):3843. PMID: 28048349.
    Citations:    
  44. Held KD, Blakely EA, Story MD, Lowenstein DI. Use of the NASA Space Radiation Laboratory at Brookhaven National Laboratory to Conduct Charged Particle Radiobiology Studies Relevant to Ion Therapy. Radiat Res. 2016 06; 185(6):563-7. PMID: 27195609; PMCID: PMC4937823.
    Citations: 6     Fields:    Translation:Humans
  45. Niimi A, Yamauchi M, Limsirichaikul S, Sekine R, Oike T, Sato H, Suzuki K, Held KD, Nakano T, Shibata A. Identification of DNA double strand breaks at chromosome boundaries along the track of particle irradiation. Genes Chromosomes Cancer. 2016 08; 55(8):650-60. PMID: 27113385.
    Citations: 5     Fields:    Translation:HumansCells
  46. Held KD, Kawamura H, Kaminuma T, Paz AE, Yoshida Y, Liu Q, Willers H, Takahashi A. Effects of Charged Particles on Human Tumor Cells. Front Oncol. 2016; 6:23. PMID: 26904502; PMCID: PMC4751258.
    Citations: 42     
  47. Liu Q, Underwood TSA, Kung J, Wang M, Lu HM, Paganetti H, Held KD, Hong TS, Efstathiou JA, Willers H. Disruption of SLX4-MUS81 Function Increases the Relative Biological Effectiveness of Proton Radiation. Int J Radiat Oncol Biol Phys. 2016 May 01; 95(1):78-85. PMID: 27084631; PMCID: PMC4889010.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  48. Held KD, Woloschak GE. NCRP Program Area Committee 1: Basic Criteria, Epidemiology, Radiobiology and Risk. Health Phys. 2016 Feb; 110(2):98-100. PMID: 26717156.
    Citations:    Fields:    
  49. Dynlacht JR, Zeman EM, Held KD, Deye J, Vikram B, Joiner MC. Education and Training Needs in the Radiation Sciences: Problems and Potential Solutions. Radiat Res. 2015 Nov; 184(5):449-55. PMID: 26479274.
    Citations: 7     Fields:    Translation:Humans
  50. Lin Y, La Tessa C, Rusek A, Held K. SU-E-T-526: Irradiation of Human Cell Lines Using Carbon Ions: Real Time Dosimetry Using Gaf-Chromic Film. Med Phys. 2015 Jun; 42(6):3456. PMID: 26128191.
    Citations:    
  51. Lin Y, Held K, McMahon S, Paganetti H, Schuemann J. SU-E-T-518: Investigation of Gold Nanoparticle Radiosensitization for Carbon Ion Therapy. Med Phys. 2015 Jun; 42(6):3454. PMID: 26128182.
    Citations:    
  52. Liu Q, Ghosh P, Magpayo N, Testa M, Tang S, Gheorghiu L, Biggs P, Paganetti H, Efstathiou JA, Lu HM, Held KD, Willers H. Lung cancer cell line screen links fanconi anemia/BRCA pathway defects to increased relative biological effectiveness of proton radiation. Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):1081-9. PMID: 25832698.
    Citations: 51     Fields:    Translation:HumansCells
  53. Liu Q, Wang M, Kern AM, Khaled S, Han J, Yeap BY, Hong TS, Settleman J, Benes CH, Held KD, Efstathiou JA, Willers H. Adapting a drug screening platform to discover associations of molecular targeted radiosensitizers with genomic biomarkers. Mol Cancer Res. 2015 Apr; 13(4):713-20. PMID: 25667133.
    Citations: 21     Fields:    Translation:HumansCells
  54. Held KD. Review of Session 7: non-cancer risk. J Radiat Res. 2014 Mar 1; 55 Suppl 1:i32-i35. PMID: 24585982.
    Citations:    
  55. Li C, Kawamura H, Khaled S, Held KD. Response of irradiated and bystander cells to charged particles in two-dimensional and three-dimensional colon models. J Radiat Res. 2014 Mar 1; 55 Suppl 1:i48-i49. PMID: 24585989.
    Citations:    
  56. Kesler CT, Kuo AH, Wong HK, Masuck DJ, Shah JL, Kozak KR, Held KD, Padera TP. Vascular endothelial growth factor-C enhances radiosensitivity of lymphatic endothelial cells. Angiogenesis. 2014 Apr; 17(2):419-27. PMID: 24201897.
    Citations: 9     Fields:    Translation:HumansCells
  57. Durante M, Reppingen N, Held KD. Immunologically augmented cancer treatment using modern radiotherapy. Trends Mol Med. 2013 Sep; 19(9):565-82. PMID: 23831337.
    Citations: 52     Fields:    Translation:Humans
  58. Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Res. 2013 Apr 15; 73(8):2574-86. PMID: 23436801; PMCID: PMC3760004.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  59. Held KD. Summary: achievements, critical issues, and thoughts on the future. Health Phys. 2012 Nov; 103(5):681-4. PMID: 23032899.
    Citations:    Fields:    Translation:Humans
  60. Butterworth KT, McGarry CK, Clasie B, Carabe-Fernandez A, Schuemann J, Depauw N, Tang S, McMahon SJ, Schettino G, O'Sullivan JM, Lu HM, Kooy H, Paganetti H, Hounsell AR, Held KD, Prise KM. Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. Phys Med Biol. 2012 Oct 21; 57(20):6671-80. PMID: 23022765.
    Citations: 5     Fields:    Translation:HumansCells
  61. Khaled S, Held KD. Radiation Biology: A Handbook for Teachers and Students Radiation Biology: A Handbook for Teachers and Students International Atomic Energy Agency Vienna: 2010; pp 149; ISSN 1018-5518. Int J Radiat Biol. 2012 Nov; 88(11):858-9. PMID: 22471625.
    Citations:    
  62. Wakatsuki M, Magpayo N, Kawamura H, Held KD. Differential bystander signaling between radioresistant chondrosarcoma cells and fibroblasts after x-ray, proton, iron ion and carbon ion exposures. Int J Radiat Oncol Biol Phys. 2012 Sep 01; 84(1):e103-8. PMID: 22537542.
    Citations: 11     Fields:    Translation:HumansCells
  63. Yang H, Magpayo N, Rusek A, Chiang IH, Sivertz M, Held KD. Effects of very low fluences of high-energy protons or iron ions on irradiated and bystander cells. Radiat Res. 2011 Dec; 176(6):695-705. PMID: 21988573.
    Citations: 13     Fields:    Translation:HumansCells
  64. Yang H, Magpayo N, Held KD. Targeted and non-targeted effects from combinations of low doses of energetic protons and iron ions in human fibroblasts. Int J Radiat Biol. 2011 Mar; 87(3):311-9. PMID: 21158498.
    Citations: 9     Fields:    Translation:HumansCells
  65. Lupi S, Baldassarre L, Mansart B, Perucchi A, Barinov A, Dudin P, Papalazarou E, Rodolakis F, Rueff JP, Itié JP, Ravy S, Nicoletti D, Postorino P, Hansmann P, Parragh N, Toschi A, Saha-Dasgupta T, Andersen OK, Sangiovanni G, Held K, Marsi M. A microscopic view on the Mott transition in chromium-doped V(2)O(3). Nat Commun. 2010 Nov 02; 1:105. PMID: 21045823.
    Citations: 12     Fields:    
  66. Purschke M, Rubio N, Held KD, Redmond RW. Phototoxicity of Hoechst 33342 in time-lapse fluorescence microscopy. Photochem Photobiol Sci. 2010 Dec; 9(12):1634-9. PMID: 20931137.
    Citations: 36     Fields:    Translation:AnimalsCells
  67. Rosenstein BS, Held KD, Rockwell S, Williams JP, Zeman EM. American Society for Radiation Oncology (ASTRO) survey of radiation biology educators in U.S. and Canadian radiation oncology residency programs. Int J Radiat Oncol Biol Phys. 2009 Nov 01; 75(3):896-905. PMID: 19733012.
    Citations: 9     Fields:    Translation:Humans
  68. Zhang Y, Zhou J, Baldwin J, Held KD, Prise KM, Redmond RW, Liber HL. Ionizing radiation-induced bystander mutagenesis and adaptation: quantitative and temporal aspects. Mutat Res. 2009 Dec 01; 671(1-2):20-5. PMID: 19695271.
    Citations: 8     Fields:    Translation:HumansCells
  69. Chakraborty A, Held KD, Prise KM, Liber HL, Redmond RW. Bystander effects induced by diffusing mediators after photodynamic stress. Radiat Res. 2009 Jul; 172(1):74-81. PMID: 19580509; PMCID: PMC2735195.
    Citations: 23     Fields:    Translation:HumansCells
  70. Kuhnert VM, Kachnic LA, Li L, Purschke M, Gheorghiu L, Lee R, Held KD, Willers H. FANCD2-deficient human fibroblasts are hypersensitive to ionising radiation at oxygen concentrations of 0% and 3% but not under normoxic conditions. Int J Radiat Biol. 2009 Jun; 85(6):523-31. PMID: 19466639; PMCID: PMC3758881.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  71. Rubio N, Rajadurai A, Held KD, Prise KM, Liber HL, Redmond RW. Real-time imaging of novel spatial and temporal responses to photodynamic stress. Free Radic Biol Med. 2009 Aug 01; 47(3):283-90. PMID: 19409981.
    Citations: 13     Fields:    Translation:AnimalsCells
  72. Held KD. Effects of low fluences of radiations found in space on cellular systems. Int J Radiat Biol. 2009 May; 85(5):379-90. PMID: 19382021.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  73. Shao C, Folkard M, Held KD, Prise KM. Estrogen enhanced cell-cell signalling in breast cancer cells exposed to targeted irradiation. BMC Cancer. 2008 Jun 30; 8:184. PMID: 18590532.
    Citations: 12     Fields:    Translation:HumansCells
  74. Zhang Y, Zhou J, Held KD, Redmond RW, Prise KM, Liber HL. Deficiencies of double-strand break repair factors and effects on mutagenesis in directly gamma-irradiated and medium-mediated bystander human lymphoblastoid cells. Radiat Res. 2008 Feb; 169(2):197-206. PMID: 18220473.
    Citations: 14     Fields:    Translation:HumansCells
  75. Willers H, Kachnic LA, Luo CM, Li L, Purschke M, Borgmann K, Held KD, Powell SN. Biomarkers and mechanisms of FANCD2 function. J Biomed Biotechnol. 2008; 2008:821529. PMID: 18483568.
    Citations: 10     Fields:    Translation:HumansCells
  76. Yang H, Anzenberg V, Held KD. The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Radiat Res. 2007 Sep; 168(3):292-8. PMID: 17705636.
    Citations: 22     Fields:    Translation:HumansCells
  77. Yang H, Anzenberg V, Held KD. Effects of heavy ions and energetic protons on normal human fibroblasts. Radiats Biol Radioecol. 2007 May-Jun; 47(3):302-6. PMID: 17867499.
    Citations: 6     Fields:    Translation:HumansCells
  78. Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. J Soc Integr Oncol. 2007; 5(1):11-7. PMID: 17309809.
    Citations: 3     Fields:    Translation:AnimalsCells
  79. Willers H, Held KD. Introduction to clinical radiation biology. Hematol Oncol Clin North Am. 2006 Feb; 20(1):1-24. PMID: 16580554.
    Citations: 18     Fields:    Translation:Humans
  80. Prise KM, Schettino G, Folkard M, Held KD. New insights on cell death from radiation exposure. Lancet Oncol. 2005 Jul; 6(7):520-8. PMID: 15992701.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  81. Muckova K, Duffield JS, Held KD, Bonventre JV, Sheridan AM. cPLA2-interacting protein, PLIP, causes apoptosis and decreases G1 phase in mesangial cells. Am J Physiol Renal Physiol. 2006 Jan; 290(1):F70-9. PMID: 15985650.
    Citations: 3     Fields:    Translation:AnimalsCells
  82. Yang H, Asaad N, Held KD. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene. 2005 Mar 17; 24(12):2096-103. PMID: 15688009.
    Citations: 70     Fields:    Translation:HumansCells
  83. Lawenda BD, Smith DE, Niemierko A, Xu L, Silverstein JR, Held KD, Loeffler JS, Jain RK, Blumberg JB. Radiomodifying responses of vitamin E and epigallocatechin gallate supplementation during irradiation of implanted tumors. J Clin Oncol. 2004 Jul 15; 22(14_suppl):9601. PMID: 28016194.
    Citations:    
  84. Schettino G, Folkard M, Prise KM, Vojnovic B, Held KD, Michael BD. Low-dose studies of bystander cell killing with targeted soft X rays. Radiat Res. 2003 Nov; 160(5):505-11. PMID: 14565833.
    Citations: 23     Fields:    Translation:AnimalsCells
  85. White SM, Held KD, Palmer MR, Yanch JC. Biological dosimetry for epithermal neutron beams. Radiat Res. 2001 Jun; 155(6):778-84. PMID: 11352759.
    Citations: 1     Fields:    Translation:AnimalsCells
  86. Tartier L, McCarey YL, Biaglow JE, Kochevar IE, Held KD. Apoptosis induced by dithiothreitol in HL-60 cells shows early activation of caspase 3 and is independent of mitochondria. Cell Death Differ. 2000 Oct; 7(10):1002-10. PMID: 11279547.
    Citations: 19     Fields:    Translation:HumansCells
  87. Biaglow JE, Donahue J, Tuttle S, Held K, Chrestensen C, Mieyal J. A method for measuring disulfide reduction by cultured mammalian cells: relative contributions of glutathione-dependent and glutathione-independent mechanisms. Anal Biochem. 2000 May 15; 281(1):77-86. PMID: 10847613.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  88. Tuttle S, Horan AM, Koch CJ, Held K, Manevich Y, Biaglow J. Radiation-sensitive tyrosine phosphorylation of cellular proteins: sensitive to changes in GSH content induced by pretreatment with N-acetyl-L-cysteine or L-buthionine-S,R-sulfoximine. Int J Radiat Oncol Biol Phys. 1998 Nov 01; 42(4):833-8. PMID: 9845106.
    Citations: 5     Fields:    Translation:AnimalsCells
  89. Manevich Y, Held KD, Biaglow JE. Coumarin-3-carboxylic acid as a detector for hydroxyl radicals generated chemically and by gamma radiation. Radiat Res. 1997 Dec; 148(6):580-91. PMID: 9399704.
    Citations: 38     Fields:    Translation:Cells
  90. Hagan MP, Hopcia KL, Sylvester FC, Held KD. Caffeine-induced apoptosis reveals a persistent lesion after treatment with bromodeoxyuridine and ultraviolet-B light. Radiat Res. 1997 Jun; 147(6):674-9. PMID: 9189164.
    Citations: 1     Fields:    Translation:AnimalsCells
  91. Kachur AV, Held KD, Koch CJ, Biaglow JE. Mechanism of production of hydroxyl radicals in the copper-catalyzed oxidation of dithiothreitol. Radiat Res. 1997 Apr; 147(4):409-15. PMID: 9092919.
    Citations: 15     Fields:    Translation:Cells
  92. Biaglow JE, Manevich Y, Uckun F, Held KD. Quantitation of hydroxyl radicals produced by radiation and copper-linked oxidation of ascorbate by 2-deoxy-D-ribose method. Free Radic Biol Med. 1997; 22(7):1129-38. PMID: 9098085.
    Citations: 9     Fields:    Translation:Cells
  93. Held KD. Radiation-induced apoptosis and its relationship to loss of clonogenic survival. Apoptosis. 1997; 2(3):265-82. PMID: 14646540.
    Citations: 5     Fields:    
  94. Biaglow JE, Held KD, Manevich Y, Tuttle S, Kachur A, Uckun F. Role of guanosine triphosphate in ferric ion-linked Fenton chemistry. Radiat Res. 1996 May; 145(5):554-62. PMID: 8619020.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  95. Held KD, Sylvester FC, Hopcia KL, Biaglow JE. Role of Fenton chemistry in thiol-induced toxicity and apoptosis. Radiat Res. 1996 May; 145(5):542-53. PMID: 8619019.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  96. Hopcia KL, McCarey YL, Sylvester FC, Held KD. Radiation-induced apoptosis in HL60 cells: oxygen effect, relationship between apoptosis and loss of clonogenicity, and dependence of time to apoptosis on radiation dose. Radiat Res. 1996 Mar; 145(3):315-23. PMID: 8927699.
    Citations: 2     Fields:    Translation:HumansCells
  97. Held KD, Biaglow JE. Mechanisms for the oxygen radical-mediated toxicity of various thiol-containing compounds in cultured mammalian cells. Radiat Res. 1994 Jul; 139(1):15-23. PMID: 8016303.
    Citations: 24     Fields:    Translation:AnimalsCells
  98. Held KD, Biaglow JE. Role of copper in the oxygen radical-mediated toxicity of the thiol-containing radioprotector dithiothreitol in mammalian cells. Radiat Res. 1993 Jun; 134(3):375-82. PMID: 8316632.
    Citations: 3     Fields:    Translation:AnimalsCells
  99. Held KD, Tuttle SW, Biaglow JE. Role of the pentose cycle in oxygen radical-mediated toxicity of the thiol-containing radioprotector dithiothreitol in mammalian cells. Radiat Res. 1993 Jun; 134(3):383-9. PMID: 8316633.
    Citations: 2     Fields:    Translation:AnimalsCells
  100. Held KD, Hopcia KL. Role of protein thiols in intrinsic radiation protection of DNA and cells. Mutat Res. 1993 May; 299(3-4):261-9. PMID: 7683093.
    Citations: 2     Fields:    Translation:AnimalsCells
  101. Awad S, Henderson GB, Cerami A, Held KD. Effects of trypanothione on the biological activity of irradiated transforming DNA. Int J Radiat Biol. 1992 Oct; 62(4):401-7. PMID: 1357053.
    Citations: 4     Fields:    Translation:Cells
  102. Biaglow JE, Mitchell JB, Held K. The importance of peroxide and superoxide in the X-ray response. Int J Radiat Oncol Biol Phys. 1992; 22(4):665-9. PMID: 1312073.
    Citations: 23     Fields:    Translation:HumansCells
  103. Held KD, Epp ER, Awad S, Biaglow JE. Postirradiation sensitization of mammalian cells by the thiol-depleting agent dimethyl fumarate. Radiat Res. 1991 Jul; 127(1):75-80. PMID: 2068274.
    Citations: 8     Fields:    Translation:Animals
  104. Harrop HA, Held KD, Michael BD. The oxygen effect: variation of the K-value and lifetimes of O2-dependent damage in some glutathione-deficient mutants of Escherichia coli. Int J Radiat Biol. 1991 May; 59(5):1237-51. PMID: 1675241.
    Citations: 1     Fields:    Translation:Cells
  105. Held KD, Awad S. Effects of polyamines and thiols on the radiation sensitivity of bacterial transforming DNA. Int J Radiat Biol. 1991 Mar; 59(3):699-710. PMID: 1672358.
    Citations: 6     Fields:    
  106. Held KD, Mirro J, Melder DC, Blakely WF, Oleinick NL, Chiu SM. Radiation-induced binding of DNA from irradiated mammalian cells to hydroxyapatite columns. Radiat Res. 1990 Sep; 123(3):268-74. PMID: 2217724.
    Citations:    Fields:    Translation:AnimalsCells
  107. Kochevar IE, Walsh AA, Held KD, Gallo RL, Mirro J. Mechanism for 193-nm laser radiation-induced effects on mammalian cells. Radiat Res. 1990 May; 122(2):142-8. PMID: 2336460.
    Citations: 1     Fields:    Translation:AnimalsCells
  108. Biaglow JE, Varnes ME, Epp ER, Clark EP, Tuttle SW, Held KD. Role of glutathione in the aerobic radiation response. Int J Radiat Oncol Biol Phys. 1989 May; 16(5):1311-4. PMID: 2715084.
    Citations: 5     Fields:    Translation:HumansCells
  109. Epp ER, Held KD, Clark EP, Biaglow JE. Effect of varying the concentration of damage restituting species in the radical repair model. Int J Radiat Oncol Biol Phys. 1989 May; 16(5):1219-23. PMID: 2715073.
    Citations:    Fields:    Translation:AnimalsCells
  110. Biaglow JE, Varnes ME, Epp ER, Clark EP, Tuttle SW, Held KD. Role of glutathione and other thiols in cellular response to radiation and drugs. Drug Metab Rev. 1989; 20(1):1-12. PMID: 2653761.
    Citations: 3     Fields:    Translation:HumansAnimalsPHPublic Health
  111. Held KD, Epp ER, Clark EP, Biaglow JE. Effect of dimethyl fumarate on the radiation sensitivity of mammalian cells in vitro. Radiat Res. 1988 Sep; 115(3):495-502. PMID: 3174933.
    Citations: 16     Fields:    Translation:AnimalsCells
  112. Biaglow JE, Varnes ME, Epp ER, Clark EP, Tuttle S, Held KD. Cellular protection against damage by hydroperoxides: role of glutathione. Basic Life Sci. 1988; 49:567-73. PMID: 2854999.
    Citations:    Fields:    Translation:Animals
  113. Held KD. Interactions of oxygen and sulfhydryls with free radicals in irradiated mammalian cells. Basic Life Sci. 1988; 49:441-8. PMID: 3250501.
    Citations:    Fields:    Translation:AnimalsCells
  114. Held KD. Models for thiol protection of DNA in cells. Pharmacol Ther. 1988; 39(1-3):123-31. PMID: 3059362.
    Citations: 4     Fields:    Translation:HumansAnimals
  115. Held KD, Melder DC. Toxicity of the sulfhydryl-containing radioprotector dithiothreitol. Radiat Res. 1987 Dec; 112(3):544-54. PMID: 3423219.
    Citations: 10     Fields:    Translation:AnimalsCells
  116. Held KD, Bren GD, Melder DC. Interactions of radioprotectors and oxygen in cultured mammalian cells. II. Effects of dithiothreitol on radiation-induced DNA damage and comparison with cell survival. Radiat Res. 1986 Dec; 108(3):296-306. PMID: 3797635.
    Citations: 1     Fields:    Translation:Cells
  117. Held KD, Bren GD. DNA damage measured using the alkaline elution assay depends on time between subculturing of cells and irradiation. Radiat Res. 1986 Feb; 105(2):211-8. PMID: 3952272.
    Citations:    Fields:    Translation:AnimalsCells
  118. Michael BD, Davies S, Held KD. Ultrafast chemical repair of DNA single and double strand break precursors in irradiated V79 cells. Basic Life Sci. 1986; 38:89-100. PMID: 3741350.
    Citations: 1     Fields:    Translation:AnimalsCells
  119. Biaglow JE, Jacobson B, Varnes ME, Held KD. Cellular oxygen utilization and hypoxia: interaction of dithiols with cellular electron transfer systems. Adv Exp Med Biol. 1986; 200:591-601. PMID: 3026149.
    Citations:    Fields:    Translation:HumansAnimalsCells
  120. Held KD, Harrop HA, Michael BD. Pulse radiolysis studies of the interactions of the sulfhydryl compound dithiothreitol and sugars. Radiat Res. 1985 Aug; 103(2):171-85. PMID: 3927392.
    Citations:    Fields:    Translation:Cells
  121. Held KD. Interactions of radioprotectors and oxygen in cultured mammalian cells. I. Dithiothreitol effects on radiation-induced cell killing. Radiat Res. 1985 Mar; 101(3):424-33. PMID: 3983360.
    Citations: 1     Fields:    Translation:AnimalsCells
  122. Held KD, Harrop HA, Michael BD. Effects of oxygen and sulphydryl-containing compounds on irradiated transforming DNA. III. Reaction rates. Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Jun; 45(6):627-36. PMID: 6429076.
    Citations: 3     Fields:    Translation:Cells
  123. Held KD, Harrop HA, Michael BD. Effects of oxygen and sulphydryl-containing compounds on irradiated transforming DNA. II. Glutathione, cysteine and cysteamine. Int J Radiat Biol Relat Stud Phys Chem Med. 1984 Jun; 45(6):615-26. PMID: 6429075.
    Citations: 3     Fields:    Translation:Cells
  124. Held KD, Harrop HA, Michael BD. Effects of oxygen and sulphydryl-containing compounds on irradiated transforming DNA. Part I. Actions of dithiothreitol. Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Dec; 40(6):613-22. PMID: 6978298.
    Citations: 2     Fields:    Translation:Cells
  125. Held KD, Powers EL. Effects of varying O2 concentration on the X-ray sensitivity of transforming DNA. Int J Radiat Biol Relat Stud Phys Chem Med. 1979 Dec; 36(6):613-9. PMID: 121992.
    Citations:    Fields:    Translation:Cells
  126. Held KD, Synek RW, Powers EL. Radiation sensitivity of transforming DNA. Int J Radiat Biol Relat Stud Phys Chem Med. 1978 Apr; 33(4):317-24. PMID: 417037.
    Citations: 1     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.