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Stephen Neil Gomperts, M.D., Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R56AG070827 (GOMPERTS, STEPHEN N.) Sep 30, 2021 - Aug 31, 2022
    NIH
    Imaging Epigenetic Mechanisms in the Lewy Body Dementias with [11C]Martinostat
    Role: Principal Investigator
  2. R41NS122576 (GOMPERTS, EDWARD) Sep 20, 2021 - Aug 31, 2023
    NIH
    HBI-002 to Treat Parkinson?s Disease
    Role: Principal Investigator
  3. R21NS109833 (GOMPERTS, STEPHEN N.) Sep 1, 2018 - Aug 31, 2021
    NIH
    Imaging Epigenetic Mechanisms in Parkinson's Disease with [11C]Martinostat
    Role: Principal Investigator
  4. R01AG054551 (GOMPERTS, STEPHEN N.) Aug 15, 2017 - Apr 30, 2022
    NIH
    Impact of Amyloid Beta on Hippocampal Neurophysiology and Calcium Activity across the Sleep-Wake Cycle
    Role: Principal Investigator
  5. R21NS090243 (GOMPERTS, STEPHEN N.) Sep 15, 2014 - Aug 31, 2016
    NIH
    PET imaging of hyperphosphorylated tau differentiates PSP and CBD from PD
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Azami H, Moguilner S, Penagos H, Sarkis RA, Arnold SE, Gomperts SN, Lam AD. EEG Entropy in REM Sleep as a Physiologic Biomarker in Early Clinical Stages of Alzheimer's Disease. J Alzheimers Dis. 2023; 91(4):1557-1572. PMID: 36641682.
    Citations:    Fields:    Translation:Humans
  2. Zhou H, Li H, Gowravaram N, Quan M, Kausar N, Gomperts SN. Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP/PS1 mouse model of Alzheimer's disease. Sci Rep. 2022 12 05; 12(1):21022. PMID: 36471155; PMCID: PMC9723144.
    Citations:    Fields:    Translation:HumansAnimals
  3. Jiang Y, Alam JJ, Gomperts SN, Maruff P, Lemstra AW, Germann UA, Stavrides PH, Darji S, Malampati S, Peddy J, Bleiwas C, Pawlik M, Pensalfini A, Yang DS, Subbanna S, Basavarajappa BS, Smiley JF, Gardner A, Blackburn K, Chu HM, Prins ND, Teunissen CE, Harrison JE, Scheltens P, Nixon RA. Preclinical and randomized clinical evaluation of the p38a kinase inhibitor neflamapimod for basal forebrain cholinergic degeneration. Nat Commun. 2022 09 21; 13(1):5308. PMID: 36130946; PMCID: PMC9492778.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  4. Scott GD, Arnold MR, Beach TG, Gibbons CH, Kanthasamy AG, Lebovitz RM, Lemstra AW, Shaw LM, Teunissen CE, Zetterberg H, Taylor AS, Graham TC, Boeve BF, Gomperts SN, Graff-Radford NR, Moussa C, Poston KL, Rosenthal LS, Sabbagh MN, Walsh RR, Weber MT, Armstrong MJ, Bang JA, Bozoki AC, Domoto-Reilly K, Duda JE, Fleisher JE, Galasko DR, Galvin JE, Goldman JG, Holden SK, Honig LS, Huddleston DE, Leverenz JB, Litvan I, Manning CA, Marder KS, Pantelyat AY, Pelak VS, Scharre DW, Sha SJ, Shill HA, Mari Z, Quinn JF, Irwin DJ. Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium. Front Neurol. 2021; 12:805135. PMID: 35173668; PMCID: PMC8841880.
    Citations: 1     
  5. Ye R, Locascio JJ, Goodheart AE, Quan M, Zhang B, Gomperts SN. Serum NFL levels predict progression of motor impairment and reduction in putamen dopamine transporter binding ratios in de novo Parkinson's disease: An 8-year longitudinal study. Parkinsonism Relat Disord. 2021 04; 85:11-16. PMID: 33639572.
    Citations: 12     Fields:    Translation:Humans
  6. Goodheart AE, Locascio JJ, Samore WR, Collins JA, Brickhouse M, Schultz A, Touroutoglou A, Johnson KA, Frosch MP, Growdon JH, Dickerson BC, Gomperts SN. 18F-AV-1451 positron emission tomography in neuropathological substrates of corticobasal syndrome. Brain. 2021 02 12; 144(1):266-277. PMID: 33578418; PMCID: PMC7880673.
    Citations: 6     Fields:    Translation:Humans
  7. Huh YE, Chiang MSR, Locascio JJ, Liao Z, Liu G, Choudhury K, Kuras YI, Tuncali I, Videnovic A, Hunt AL, Schwarzschild MA, Hung AY, Herrington TM, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Sardi SP, Scherzer CR. ß-Glucocerebrosidase activity in GBA-linked Parkinson disease: The type of mutation matters. Neurology. 2020 08 11; 95(6):e685-e696. PMID: 32540937; PMCID: PMC7455354.
    Citations: 15     Fields:    Translation:Humans
  8. McKeith IG, Ferman TJ, Thomas AJ, Blanc F, Boeve BF, Fujishiro H, Kantarci K, Muscio C, O'Brien JT, Postuma RB, Aarsland D, Ballard C, Bonanni L, Donaghy P, Emre M, Galvin JE, Galasko D, Goldman JG, Gomperts SN, Honig LS, Ikeda M, Leverenz JB, Lewis SJG, Marder KS, Masellis M, Salmon DP, Taylor JP, Tsuang DW, Walker Z, Tiraboschi P. Research criteria for the diagnosis of prodromal dementia with Lewy bodies. Neurology. 2020 04 28; 94(17):743-755. PMID: 32241955; PMCID: PMC7274845.
    Citations: 112     Fields:    Translation:Humans
  9. Ye R, Touroutoglou A, Brickhouse M, Katz S, Growdon JH, Johnson KA, Dickerson BC, Gomperts SN. Topography of cortical thinning in the Lewy body diseases. Neuroimage Clin. 2020; 26:102196. PMID: 32059167.
    Citations: 6     Fields:    Translation:Humans
  10. Bakshi R, Macklin EA, Hung AY, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Ascherio A, Scherzer CR, Schwarzschild MA. Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study. J Parkinsons Dis. 2020; 10(2):505-510. PMID: 32250320.
    Citations: 12     Fields:    Translation:Humans
  11. Shirvan J, Clement N, Ye R, Katz S, Schultz A, Johnson KA, Gomez-Isla T, Frosch M, Growdon JH, Gomperts SN. Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease. Neurology. 2019 07 30; 93(5):e476-e484. PMID: 31243072; PMCID: PMC6693430.
    Citations: 8     Fields:    Translation:Humans
  12. Kastanenka KV, Calvo-Rodriguez M, Hou SS, Zhou H, Takeda S, Arbel-Ornath M, Lariviere A, Lee YF, Kim A, Hawkes JM, Logan R, Feng D, Chen X, Gomperts SN, Bacskai BJ. Frequency-dependent exacerbation of Alzheimer's disease neuropathophysiology. Sci Rep. 2019 06 20; 9(1):8964. PMID: 31221985.
    Citations: 19     Fields:    Translation:AnimalsCells
  13. Peterson B, Armstrong M, Galasko D, Galvin JE, Goldman J, Irwin D, Paulson H, Kaufer D, Leverenz J, Lunde A, McKeith IG, Siderowf A, Taylor A, Amodeo K, Barrett M, Domoto-Reilly K, Duda J, Gomperts S, Graff-Radford N, Holden S, Honig L, Huddleston D, Lippa C, Litvan I, Manning C, Marder K, Moussa C, Onyike C, Pagan F, Pantelyat A, Pelak V, Poston K, Quinn J, Richard I, Rosenthal LS, Sabbagh M, Scharre D, Sha S, Shill H, Torres-Yaghi Y, Christie T, Graham T, Richards I, Koehler M, Boeve B. Lewy Body Dementia Association's Research Centers of Excellence Program: Inaugural Meeting Proceedings. Alzheimers Res Ther. 2019 03 13; 11(1):23. PMID: 30867052.
    Citations: 2     Fields:    Translation:Humans
  14. Zhou H, Neville KR, Goldstein N, Kabu S, Kausar N, Ye R, Nguyen TT, Gelwan N, Hyman BT, Gomperts SN. Cholinergic modulation of hippocampal calcium activity across the sleep-wake cycle. Elife. 2019 03 07; 8. PMID: 30843520.
    Citations: 15     Fields:    Translation:AnimalsCells
  15. Marquié M, Verwer EE, Meltzer AC, Kim SJW, Agüero C, Gonzalez J, Makaretz SJ, Siao Tick Chong M, Ramanan P, Amaral AC, Normandin MD, Vanderburg CR, Gomperts SN, Johnson KA, Frosch MP, Gómez-Isla T. Lessons learned about [F-18]-AV-1451 off-target binding from an autopsy-confirmed Parkinson's case. Acta Neuropathol Commun. 2017 10 19; 5(1):75. PMID: 29047416.
    Citations: 50     Fields:    Translation:Humans
  16. Schonhaut DR, McMillan CT, Spina S, Dickerson BC, Siderowf A, Devous MD, Tsai R, Winer J, Russell DS, Litvan I, Roberson ED, Seeley WW, Grinberg LT, Kramer JH, Miller BL, Pressman P, Nasrallah I, Baker SL, Gomperts SN, Johnson KA, Grossman M, Jagust WJ, Boxer AL, Rabinovici GD. 18 F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study. Ann Neurol. 2017 Oct; 82(4):622-634. PMID: 28980714.
    Citations: 74     Fields:    Translation:Humans
  17. McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, Bras J, Brundin P, Burn D, Chen-Plotkin A, Duda JE, El-Agnaf O, Feldman H, Ferman TJ, Ffytche D, Fujishiro H, Galasko D, Goldman JG, Gomperts SN, Graff-Radford NR, Honig LS, Iranzo A, Kantarci K, Kaufer D, Kukull W, Lee VMY, Leverenz JB, Lewis S, Lippa C, Lunde A, Masellis M, Masliah E, McLean P, Mollenhauer B, Montine TJ, Moreno E, Mori E, Murray M, O'Brien JT, Orimo S, Postuma RB, Ramaswamy S, Ross OA, Salmon DP, Singleton A, Taylor A, Thomas A, Tiraboschi P, Toledo JB, Trojanowski JQ, Tsuang D, Walker Z, Yamada M, Kosaka K. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. 2017 Jul 04; 89(1):88-100. PMID: 28592453.
    Citations: 1017     Fields:    Translation:Humans
  18. Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol. 2017 04 01; 74(4):427-436. PMID: 28241163; PMCID: PMC5470368.
    Citations: 127     Fields:    Translation:Humans
  19. Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, Oakley DH, Gomperts SN, Growdon JH, Domoto-Reilly K, Lucente D, Dickerson BC, Frosch MP, Hyman BT, Johnson KA, Gómez-Isla T. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann Neurol. 2017 Jan; 81(1):117-128. PMID: 27997036; PMCID: PMC5319193.
    Citations: 102     Fields:    Translation:Humans
  20. Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, Sperling R, Growdon JH, Dickerson BC, Johnson K. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. JAMA Neurol. 2016 Nov 01; 73(11):1334-1341. PMID: 27654968; PMCID: PMC5287290.
    Citations: 97     Fields:    Translation:Humans
  21. Gomperts SN. Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia. Continuum (Minneap Minn). 2016 Apr; 22(2 Dementia):435-63. PMID: 27042903.
    Citations: 54     Fields:    Translation:Humans
  22. Gomperts SN, Marquie M, Locascio JJ, Bayer S, Johnson KA, Growdon JH. PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies. Neurodegener Dis. 2016; 16(1-2):118-24. PMID: 26655867.
    Citations: 19     Fields:    
  23. Gomperts SN, Kloosterman F, Wilson MA. VTA neurons coordinate with the hippocampal reactivation of spatial experience. Elife. 2015 Oct 14; 4. PMID: 26465113.
    Citations: 61     Fields:    Translation:AnimalsCells
  24. Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, Frosch MP, Hyman BT, Gómez-Isla T. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov; 78(5):787-800. PMID: 26344059; PMCID: PMC4900162.
    Citations: 316     Fields:    Translation:HumansCells
  25. Rieckmann A, Gomperts SN, Johnson KA, Growdon JH, Van Dijk KR. Putamen-midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases. Neuroimage Clin. 2015; 8:554-9. PMID: 26137443.
    Citations: 14     Fields:    Translation:Humans
  26. Marquie M, Locascio JJ, Rentz DM, Becker JA, Hedden T, Johnson KA, Growdon JH, Gomperts SN. Striatal and extrastriatal dopamine transporter levels relate to cognition in Lewy body diseases: an (11)C altropane positron emission tomography study. Alzheimers Res Ther. 2014; 6(5-8):52. PMID: 25429309.
    Citations: 14     Fields:    
  27. Gomperts SN. Imaging the role of amyloid in PD dementia and dementia with Lewy bodies. Curr Neurol Neurosci Rep. 2014 Aug; 14(8):472. PMID: 25011528.
    Citations: 18     Fields:    Translation:Humans
  28. Chen Z, Gomperts SN, Yamamoto J, Wilson MA. Neural representation of spatial topology in the rodent hippocampus. Neural Comput. 2014 Jan; 26(1):1-39. PMID: 24102128.
    Citations: 28     Fields:    Translation:AnimalsCells
  29. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7. PMID: 24068787; PMCID: PMC3888173.
    Citations: 55     Fields:    Translation:Humans
  30. Gomperts SN, Johnson KA, Growdon J. Reply: Beyond the limits of detection: failure of PiB imaging to capture true Aß burden. Mov Disord. 2013 Mar; 28(3):407. PMID: 23401107.
    Citations: 2     Fields:    Translation:Humans
  31. Gomperts SN, Locascio JJ, Rentz D, Santarlasci A, Marquie M, Johnson KA, Growdon JH. Amyloid is linked to cognitive decline in patients with Parkinson disease without dementia. Neurology. 2013 Jan 01; 80(1):85-91. PMID: 23243071; PMCID: PMC3589197.
    Citations: 77     Fields:    Translation:Humans
  32. Gomperts SN, Locascio JJ, Marquie M, Santarlasci AL, Rentz DM, Maye J, Johnson KA, Growdon JH. Brain amyloid and cognition in Lewy body diseases. Mov Disord. 2012 Jul; 27(8):965-73. PMID: 22693110.
    Citations: 68     Fields:    Translation:Humans
  33. Nguyen DP, Layton SP, Hale G, Gomperts SN, Davidson TJ, Kloosterman F, Wilson MA. Micro-drive array for chronic in vivo recording: tetrode assembly. J Vis Exp. 2009 Apr 22; (26). PMID: 19387422.
    Citations: 37     Fields:    Translation:Cells
  34. Kloosterman F, Davidson TJ, Gomperts SN, Layton SP, Hale G, Nguyen DP, Wilson MA. Micro-drive array for chronic in vivo recording: drive fabrication. J Vis Exp. 2009 Apr 20; (26). PMID: 19381129.
    Citations: 40     Fields:    Translation:AnimalsCells
  35. Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA. Imaging amyloid deposition in Lewy body diseases. Neurology. 2008 Sep 16; 71(12):903-10. PMID: 18794492; PMCID: PMC2637553.
    Citations: 175     Fields:    Translation:Humans
  36. Gomperts SN, Carroll R, Malenka RC, Nicoll RA. Distinct roles for ionotropic and metabotropic glutamate receptors in the maturation of excitatory synapses. J Neurosci. 2000 Mar 15; 20(6):2229-37. PMID: 10704498; PMCID: PMC6772494.
    Citations: 31     Fields:    Translation:AnimalsCells
  37. Kalman D, Gomperts SN, Hardy S, Kitamura M, Bishop JM. Ras family GTPases control growth of astrocyte processes. Mol Biol Cell. 1999 May; 10(5):1665-83. PMID: 10233170; PMCID: PMC30489.
    Citations: 23     Fields:    Translation:AnimalsCells
  38. Gomperts SN, Rao A, Craig AM, Malenka RC, Nicoll RA. Postsynaptically silent synapses in single neuron cultures. Neuron. 1998 Dec; 21(6):1443-51. PMID: 9883736.
    Citations: 38     Fields:    Translation:AnimalsCells
  39. Lissin DV, Gomperts SN, Carroll RC, Christine CW, Kalman D, Kitamura M, Hardy S, Nicoll RA, Malenka RC, von Zastrow M. Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):7097-102. PMID: 9618545; PMCID: PMC22752.
    Citations: 119     Fields:    Translation:AnimalsCells
  40. Gomperts SN. Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family. Cell. 1996 Mar 08; 84(5):659-62. PMID: 8625403.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.