Harvard Catalyst Profiles

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Wayne A. Marasco, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI142502 (MARASCO, WAYNE A.) Aug 1, 2019 - Jul 31, 2021
    The role of Ig Polymorphism in shaping the Broadly Neutralizing Antibody Response to Hemagglutinin HA stem domain(s) of Influenza A, Group 1 and 2 Viruses
    Role: Principal Investigator
  2. R21AI142590 (WATSON, COREY TAYLOR) Nov 15, 2018 - Oct 31, 2020
    Population level characterization of human immunoglobulin heavy chain germline variants with impacts on variability in the Ab repertoire of healthy adults
    Role: Co-Principal Investigator
  3. R01AI121285 (MARASCO, WAYNE A.) Nov 9, 2015 - Oct 31, 2020
    Studies of IGHV Germline Gene Polymorphism, Utilization & Shifting for Seasonal Influenza Vaccine Induced Broadly Neutralizing Antibody Responses
    Role: Principal Investigator
  4. R56AI109223 (MARASCO, WAYNE A.) Sep 11, 2014 - Aug 31, 2016
    Structural Requirements for Broadly Protecting Antibodies to Influenza A & B
    Role: Principal Investigator
  5. R21AI091557 (MARASCO, WAYNE A.) Jul 1, 2010 - Jun 30, 2013
    Study of broadly neutralizing antibody generation to HIV gp140 in humanized mice
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Harshbarger WD, Deming D, Lockbaum GJ, Attatippaholkun N, Kamkaew M, Hou S, Somasundaran M, Wang JP, Finberg RW, Zhu QK, Schiffer CA, Marasco WA. Unique structural solution from a VH3-30 antibody targeting the hemagglutinin stem of influenza A viruses. Nat Commun. 2021 01 25; 12(1):559. PMID: 33495478.
    Citations:    Fields:    Translation:HumansCells
  2. Wang Y, Chan LL, Grimaud M, Fayed A, Zhu Q, Marasco WA. High-Throughput Image Cytometry Detection Method for CAR-T Transduction, Cell Proliferation, and Cytotoxicity Assays. Cytometry A. 2020 Nov 15. PMID: 33191639.
    Citations:    Fields:    
  3. Rodriguez OL, Gibson WS, Parks T, Emery M, Powell J, Strahl M, Deikus G, Auckland K, Eichler EE, Marasco WA, Sebra R, Sharp AJ, Smith ML, Bashir A, Watson CT. A Novel Framework for Characterizing Genomic Haplotype Diversity in the Human Immunoglobulin Heavy Chain Locus. Front Immunol. 2020; 11:2136. PMID: 33072076.
    Citations: 1     Fields:    
  4. Ogata AF, Maley AM, Wu C, Gilboa T, Norman M, Lazarovits R, Mao CP, Newton G, Chang M, Nguyen K, Kamkaew M, Zhu Q, Gibson TE, Ryan ET, Charles RC, Marasco WA, Walt DR. Ultra-sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease. Clin Chem. 2020 Sep 08. PMID: 32897389.
    Citations: 7     Fields:    
  5. Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. Author Correction: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2020 Jul; 26(7):1146. PMID: 32661400.
    Citations:    Fields:    
  6. Saleh FM, Chandra PK, Lin D, Robinson JE, Izadpanah R, Mondal D, Bollensdorff C, Alt EU, Zhu Q, Marasco WA, Braun SE, Abdel-Motal UM. A New Humanized Mouse Model Mimics Humans in Lacking a-Gal Epitopes and Secreting Anti-Gal Antibodies. J Immunol. 2020 04 01; 204(7):1998-2005. PMID: 32144163.
    Citations: 1     Fields:    Translation:HumansAnimals
  7. Magnotti EL, Chan LL, Zhu Q, Marasco WA. A high-throughput chemotaxis detection method for CCR4+ T cell migration inhibition using image cytometry. J Immunol Methods. 2020 04; 479:112747. PMID: 31958449.
    Citations: 1     Fields:    Translation:HumansCells
  8. Prachanronarong KL, Canale AS, Liu P, Somasundaran M, Hou S, Poh YP, Han T, Zhu Q, Renzette N, Zeldovich KB, Kowalik TF, Kurt-Yilmaz N, Jensen JD, Bolon DNA, Marasco WA, Finberg RW, Schiffer CA, Wang JP. Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody. J Virol. 2019 01 15; 93(2). PMID: 30381484.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Samuelson DR, Siggins RW, Ruan S, Amedee AM, Sun J, Zhu QK, Marasco WA, Taylor CM, Luo M, Welsh DA, Shellito JE. Alcohol consumption increases susceptibility to pneumococcal pneumonia in a humanized murine HIV model mediated by intestinal dysbiosis. Alcohol. 2019 11; 80:33-43. PMID: 30213614.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. Canale AS, Venev SV, Whitfield TW, Caffrey DR, Marasco WA, Schiffer CA, Kowalik TF, Jensen JD, Finberg RW, Zeldovich KB, Wang JP, Bolon DNA. Synonymous Mutations at the Beginning of the Influenza A Virus Hemagglutinin Gene Impact Experimental Fitness. J Mol Biol. 2018 04 13; 430(8):1098-1115. PMID: 29466705.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  11. Magnotti E, Marasco WA. The latest animal models of ovarian cancer for novel drug discovery. Expert Opin Drug Discov. 2018 03; 13(3):249-257. PMID: 29338446.
    Citations: 7     Fields:    Translation:HumansAnimals
  12. Avnir Y, Prachanronarong KL, Zhang Z, Hou S, Peterson EC, Sui J, Zayed H, Kurella VB, McGuire AT, Stamatatos L, Hilbert BJ, Bohn MF, Kowalik TF, Jensen JD, Finberg RW, Wang JP, Goodall M, Jefferis R, Zhu Q, Kurt Yilmaz N, Schiffer CA, Marasco WA. Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope. Cell Rep. 2017 Dec 12; 21(11):3243-3255. PMID: 29241550.
    Citations: 5     Fields:    Translation:HumansCells
  13. Pierce CL, Williams TL, Santana WI, Levine M, Chen LM, Cooper HC, Solano MI, Woolfitt AR, Marasco WA, Fang H, Donis RO, Barr JR. Immunocapture isotope dilution mass spectrometry in response to a pandemic influenza threat. Vaccine. 2017 09 05; 35(37):5011-5018. PMID: 28774565.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  14. Watson CT, Glanville J, Marasco WA. The Individual and Population Genetics of Antibody Immunity. Trends Immunol. 2017 07; 38(7):459-470. PMID: 28539189.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  15. Cockrell AS, Yount BL, Scobey T, Jensen K, Douglas M, Beall A, Tang XC, Marasco WA, Heise MT, Baric RS. A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol. 2016 Nov 28; 2:16226. PMID: 27892925.
    Citations: 82     Fields:    Translation:AnimalsCells
  16. Simmons M, Putnak R, Sun P, Burgess T, Marasco WA. Antibody Prophylaxis Against Dengue Virus 2 Infection in Non-Human Primates. Am J Trop Med Hyg. 2016 Nov 02; 95(5):1148-1156. PMID: 27645784.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  17. Fu Y, Zhang Z, Sheehan J, Avnir Y, Ridenour C, Sachnik T, Sun J, Hossain MJ, Chen LM, Zhu Q, Donis RO, Marasco WA. A broadly neutralizing anti-influenza antibody reveals ongoing capacity of haemagglutinin-specific memory B cells to evolve. Nat Commun. 2016 09 13; 7:12780. PMID: 27619409.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  18. Suarez ER, Chang de K, Sun J, Sui J, Freeman GJ, Signoretti S, Zhu Q, Marasco WA. Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model. Oncotarget. 2016 Jun 07; 7(23):34341-55. PMID: 27145284.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  19. Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q, Marasco WA. Erratum: IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity. Sci Rep. 2016 04 29; 6:23876. PMID: 27125899.
    Citations: 1     Fields:    
  20. Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2016 Apr; 22(4):446. PMID: 27050591.
    Citations: 1     Fields:    
  21. Menachery VD, Yount BL, Sims AC, Debbink K, Agnihothram SS, Gralinski LE, Graham RL, Scobey T, Plante JA, Royal SR, Swanstrom J, Sheahan TP, Pickles RJ, Corti D, Randell SH, Lanzavecchia A, Marasco WA, Baric RS. SARS-like WIV1-CoV poised for human emergence. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3048-53. PMID: 26976607.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  22. Chang DK, Kurella VB, Biswas S, Avnir Y, Sui J, Wang X, Sun J, Wang Y, Panditrao M, Peterson E, Tallarico A, Fernandes S, Goodall M, Zhu Q, Brown JR, Jefferis R, Marasco WA. Humanized mouse G6 anti-idiotypic monoclonal antibody has therapeutic potential against IGHV1-69 germline gene-based B-CLL. MAbs. 2016 May-Jun; 8(4):787-98. PMID: 26963739.
    Citations: 3     Fields:    Translation:HumansAnimals
  23. Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q, Marasco WA. IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity. Sci Rep. 2016 Feb 16; 6:20842. PMID: 26880249.
    Citations: 32     Fields:    Translation:HumansCells
  24. Johnson RF, Bagci U, Keith L, Tang X, Mollura DJ, Zeitlin L, Qin J, Huzella L, Bartos CJ, Bohorova N, Bohorov O, Goodman C, Kim DH, Paulty MH, Velasco J, Whaley KJ, Johnson JC, Pettitt J, Ork BL, Solomon J, Oberlander N, Zhu Q, Sun J, Holbrook MR, Olinger GG, Baric RS, Hensley LE, Jahrling PB, Marasco WA. 3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012. Virology. 2016 03; 490:49-58. PMID: 26828465.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  25. Chang DK, Peterson E, Sun J, Goudie C, Drapkin RI, Liu JF, Matulonis U, Zhu Q, Marasco WA. Anti-CCR4 monoclonal antibody enhances antitumor immunity by modulating tumor-infiltrating Tregs in an ovarian cancer xenograft humanized mouse model. Oncoimmunology. 2016 Mar; 5(3):e1090075. PMID: 27141347.
    Citations: 18     
  26. Menachery VD, Yount BL, Debbink K, Agnihothram S, Gralinski LE, Plante JA, Graham RL, Scobey T, Ge XY, Donaldson EF, Randell SH, Lanzavecchia A, Marasco WA, Shi ZL, Baric RS. A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence. Nat Med. 2015 Dec; 21(12):1508-13. PMID: 26552008.
    Citations: 226     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  27. Freund NT, Roitburd-Berman A, Sui J, Marasco WA, Gershoni JM. Reconstitution of the receptor-binding motif of the SARS coronavirus. Protein Eng Des Sel. 2015 Dec; 28(12):567-75. PMID: 26487711.
    Citations: 5     Fields:    Translation:HumansCells
  28. Tang XC, Marasco WA. Human neutralizing antibodies against MERS coronavirus: implications for future immunotherapy. Immunotherapy. 2015; 7(6):591-4. PMID: 26098703.
    Citations: 2     Fields:    Translation:HumansCells
  29. Chang DK, Moniz RJ, Xu Z, Sun J, Signoretti S, Zhu Q, Marasco WA. Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinoma in vitro and in a humanized mouse model in vivo. Mol Cancer. 2015 Jun 11; 14:119. PMID: 26062742.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  30. Huang X, Dong W, Milewska A, Golda A, Qi Y, Zhu QK, Marasco WA, Baric RS, Sims AC, Pyrc K, Li W, Sui J. Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme. J Virol. 2015 Jul; 89(14):7202-13. PMID: 25926653.
    Citations: 77     Fields:    Translation:HumansCells
  31. Goettel JA, Biswas S, Lexmond WS, Yeste A, Passerini L, Patel B, Yang S, Sun J, Ouahed J, Shouval DS, McCann KJ, Horwitz BH, Mathis D, Milford EL, Notarangelo LD, Roncarolo MG, Fiebiger E, Marasco WA, Bacchetta R, Quintana FJ, Pai SY, Klein C, Muise AM, Snapper SB. Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3. Blood. 2015 Jun 18; 125(25):3886-95. PMID: 25833964.
    Citations: 15     Fields:    Translation:HumansAnimals
  32. Sheehan J, Marasco WA. Phage and Yeast Display. Microbiol Spectr. 2015 Feb; 3(1):AID-0028-2014. PMID: 26104550.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  33. Lo AS, Xu C, Murakami A, Marasco WA. Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T cells expressing a human anti-CAIX chimeric antigen receptor. Mol Ther Oncolytics. 2014; 1:14003. PMID: 27119093.
    Citations: 3     
  34. Kang W, Marasco WA, Tong HI, Byron MM, Wu C, Shi Y, Sun S, Sun Y, Lu Y. Anti-tat Hutat2:Fc mediated protection against tat-induced neurotoxicity and HIV-1 replication in human monocyte-derived macrophages. J Neuroinflammation. 2014 Nov 22; 11:195. PMID: 25416164.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  35. Sui J, Deming M, Rockx B, Liddington RC, Zhu QK, Baric RS, Marasco WA. Effects of human anti-spike protein receptor binding domain antibodies on severe acute respiratory syndrome coronavirus neutralization escape and fitness. J Virol. 2014 Dec; 88(23):13769-80. PMID: 25231316.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  36. Abdel-Motal UM, Harbison C, Han T, Pudney J, Anderson DJ, Zhu Q, Westmoreland S, Marasco WA. Prolonged expression of an anti-HIV-1 gp120 minibody to the female rhesus macaque lower genital tract by AAV gene transfer. Gene Ther. 2014 Sep; 21(9):802-10. PMID: 24965083.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  37. Avnir Y, Tallarico AS, Zhu Q, Bennett AS, Connelly G, Sheehan J, Sui J, Fahmy A, Huang CY, Cadwell G, Bankston LA, McGuire AT, Stamatatos L, Wagner G, Liddington RC, Marasco WA. Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses. PLoS Pathog. 2014 May; 10(5):e1004103. PMID: 24788925.
    Citations: 48     Fields:    Translation:HumansCells
  38. Tang XC, Agnihothram SS, Jiao Y, Stanhope J, Graham RL, Peterson EC, Avnir Y, Tallarico AS, Sheehan J, Zhu Q, Baric RS, Marasco WA. Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution. Proc Natl Acad Sci U S A. 2014 May 13; 111(19):E2018-26. PMID: 24778221.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  39. Almagro JC, Gilliland GL, Breden F, Scott JK, Sok D, Pauthner M, Reichert JM, Helguera G, Andrabi R, Mabry R, Bléry M, Voss JE, Laurén J, Abuqayyas L, Barghorn S, Ben-Jacob E, Crowe JE, Huston JS, Johnston SA, Krauland E, Lund-Johansen F, Marasco WA, Parren PW, Xu KY. Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA. MAbs. 2014 May-Jun; 6(3):577-618. PMID: 24589717.
    Citations: 1     Fields:    Translation:HumansAnimals
  40. Hall SR, Jiang Y, Leary E, Yavanian G, Eminli S, O'Neill DW, Marasco WA. Identification and isolation of small CD44-negative mesenchymal stem/progenitor cells from human bone marrow using elutriation and polychromatic flow cytometry. Stem Cells Transl Med. 2013 Aug; 2(8):567-78. PMID: 23847000.
    Citations: 4     Fields:    Translation:HumansCells
  41. Zhang J, Valianou M, Simmons H, Robinson MK, Lee HO, Mullins SR, Marasco WA, Adams GP, Weiner LM, Cheng JD. Identification of inhibitory scFv antibodies targeting fibroblast activation protein utilizing phage display functional screens. FASEB J. 2013 Feb; 27(2):581-9. PMID: 23104982.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Han T, Abdel-Motal UM, Chang DK, Sui J, Muvaffak A, Campbell J, Zhu Q, Kupper TS, Marasco WA. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma. PLoS One. 2012; 7(9):e44455. PMID: 22973452.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  43. Braun SE, Taube R, Zhu Q, Wong FE, Murakami A, Kamau E, Dwyer M, Qiu G, Daigle J, Carville A, Johnson RP, Marasco WA. In vivo selection of CD4(+) T cells transduced with a gamma-retroviral vector expressing a single-chain intrabody targeting HIV-1 tat. Hum Gene Ther. 2012 Sep; 23(9):917-31. PMID: 22734618.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  44. Vyas JM, Marasco WA. Fatal fulminant hepatic failure from adenovirus in allogeneic bone marrow transplant patients. Case Rep Infect Dis. 2012; 2012:463569. PMID: 22928129.
    Citations: 2     
  45. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. . 2012 Nov; 11(11):2451-61. PMID: 22869555.
    Citations: 24     Translation:HumansAnimalsCells
  46. Hammond SP, Gagne LS, Stock SR, Marty FM, Gelman RS, Marasco WA, Poritz MA, Baden LR. Respiratory virus detection in immunocompromised patients with FilmArray respiratory panel compared to conventional methods. J Clin Microbiol. 2012 Oct; 50(10):3216-21. PMID: 22814461.
    Citations: 23     Fields:    Translation:HumansCells
  47. Chang H, Biswas S, Tallarico AS, Sarkis PT, Geng S, Panditrao MM, Zhu Q, Marasco WA. Human B-cell ontogeny in humanized NOD/SCID ?c(null) mice generates a diverse yet auto/poly- and HIV-1-reactive antibody repertoire. Genes Immun. 2012 Jul; 13(5):399-410. PMID: 22592523.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  48. Biswas S, Chang H, Sarkis PT, Fikrig E, Zhu Q, Marasco WA. Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV-1 envelope proteins are largely mediated via human CD5+ B cells. Immunology. 2011 Dec; 134(4):419-33. PMID: 22044090.
    Citations: 38     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  49. Abdel-Motal UM, Sarkis PT, Han T, Pudney J, Anderson DJ, Zhu Q, Marasco WA. Anti-gp120 minibody gene transfer to female genital epithelial cells protects against HIV-1 virus challenge in vitro. PLoS One. 2011; 6(10):e26473. PMID: 22031835.
    Citations: 11     Fields:    Translation:HumansCells
  50. Han T, Sui J, Bennett AS, Liddington RC, Donis RO, Zhu Q, Marasco WA. Fine epitope mapping of monoclonal antibodies against hemagglutinin of a highly pathogenic H5N1 influenza virus using yeast surface display. Biochem Biophys Res Commun. 2011 Jun 03; 409(2):253-9. PMID: 21569761.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  51. Sui J, Sheehan J, Hwang WC, Bankston LA, Burchett SK, Huang CY, Liddington RC, Beigel JH, Marasco WA. Wide prevalence of heterosubtypic broadly neutralizing human anti-influenza A antibodies. Clin Infect Dis. 2011 Apr 15; 52(8):1003-9. PMID: 21460314.
    Citations: 70     Fields:    Translation:HumansCells
  52. Han T, Marasco WA. Structural basis of influenza virus neutralization. Ann N Y Acad Sci. 2011 Jan; 1217:178-90. PMID: 21251008.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  53. Wrammert J, Koutsonanos D, Li GM, Edupuganti S, Sui J, Morrissey M, McCausland M, Skountzou I, Hornig M, Lipkin WI, Mehta A, Razavi B, Del Rio C, Zheng NY, Lee JH, Huang M, Ali Z, Kaur K, Andrews S, Amara RR, Wang Y, Das SR, O'Donnell CD, Yewdell JW, Subbarao K, Marasco WA, Mulligan MJ, Compans R, Ahmed R, Wilson PC. Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection. J Exp Med. 2011 Jan 17; 208(1):181-93. PMID: 21220454.
    Citations: 410     Fields:    Translation:HumansAnimalsCells
  54. Hashem AM, Van Domselaar G, Li C, Wang J, She YM, Cyr TD, Sui J, He R, Marasco WA, Li X. Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus. Biochem Biophys Res Commun. 2010 Dec 10; 403(2):247-51. PMID: 21078301.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  55. Herschhorn A, Marasco WA, Hizi A. Antibodies and lentiviruses that specifically recognize a T cell epitope derived from HIV-1 Nef protein and presented by HLA-C. J Immunol. 2010 Dec 15; 185(12):7623-32. PMID: 21076072.
    Citations: 10     Fields:    Translation:HumansCells
  56. Kuan CT, Srivastava N, McLendon RE, Marasco WA, Zalutsky MR, Bigner DD. Recombinant single-chain variable fragment antibodies against extracellular epitopes of human multidrug resistance protein MRP3 for targeting malignant gliomas. Int J Cancer. 2010 Aug 01; 127(3):598-611. PMID: 19937796.
    Citations: 12     Fields:    Translation:HumansCells
  57. Xu C, Lo A, Yammanuru A, Tallarico AS, Brady K, Murakami A, Barteneva N, Zhu Q, Marasco WA. Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology. PLoS One. 2010 Mar 10; 5(3):e9625. PMID: 20224781.
    Citations: 15     Fields:    Translation:HumansCells
  58. Centeno CJ, Schultz JR, Cheever M, Robinson B, Freeman M, Marasco W. Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell Res Ther. 2010 Mar; 5(1):81-93. PMID: 19951252.
    Citations: 45     Fields:    Translation:HumansCells
  59. Sultana H, Foellmer HG, Neelakanta G, Oliphant T, Engle M, Ledizet M, Krishnan MN, Bonafé N, Anthony KG, Marasco WA, Kaplan P, Montgomery RR, Diamond MS, Koski RA, Fikrig E. Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody. J Immunol. 2009 Jul 01; 183(1):650-60. PMID: 19535627.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  60. Gennari F, Lopes L, Verhoeyen E, Marasco W, Collins MK. Single-chain antibodies that target lentiviral vectors to MHC class II on antigen-presenting cells. Hum Gene Ther. 2009 Jun; 20(6):554-62. PMID: 19260768.
    Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  61. Sui J, Hwang WC, Perez S, Wei G, Aird D, Chen LM, Santelli E, Stec B, Cadwell G, Ali M, Wan H, Murakami A, Yammanuru A, Han T, Cox NJ, Bankston LA, Donis RO, Liddington RC, Marasco WA. Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat Struct Mol Biol. 2009 Mar; 16(3):265-73. PMID: 19234466.
    Citations: 570     Fields:    Translation:HumansAnimalsCells
  62. Nakase K, Cheng J, Zhu Q, Marasco WA. Mechanisms of SHP-1 P2 promoter regulation in hematopoietic cells and its silencing in HTLV-1-transformed T cells. J Leukoc Biol. 2009 Jan; 85(1):165-74. PMID: 18948549.
    Citations: 11     Fields:    Translation:HumansCells
  63. Sui J, Aird DR, Tamin A, Murakami A, Yan M, Yammanuru A, Jing H, Kan B, Liu X, Zhu Q, Yuan QA, Adams GP, Bellini WJ, Xu J, Anderson LJ, Marasco WA. Broadening of neutralization activity to directly block a dominant antibody-driven SARS-coronavirus evolution pathway. PLoS Pathog. 2008 Nov; 4(11):e1000197. PMID: 18989460.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  64. Taube R, Zhu Q, Xu C, Diaz-Griffero F, Sui J, Kamau E, Dwyer M, Aird D, Marasco WA. Lentivirus display: stable expression of human antibodies on the surface of human cells and virus particles. PLoS One. 2008 Sep 11; 3(9):e3181. PMID: 18784843.
    Citations: 6     Fields:    Translation:HumansCells
  65. Huang IC, Li W, Sui J, Marasco W, Choe H, Farzan M. Influenza A virus neuraminidase limits viral superinfection. J Virol. 2008 May; 82(10):4834-43. PMID: 18321971.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  66. Lo AS, Zhu Q, Marasco WA. Intracellular antibodies (intrabodies) and their therapeutic potential. Handb Exp Pharmacol. 2008; (181):343-73. PMID: 18071953.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  67. Rodgerson D, Rothenberg R and Marasco WA. . The Collection, Processing and Storage of Adult Stem Cells – A Bio-Insurance Policy for Personalized Medical Therapies. Life Extension Foundation magazine. 2008.
  68. Marasco WA, Sui J. The growth and potential of human antiviral monoclonal antibody therapeutics. Nat Biotechnol. 2007 Dec; 25(12):1421-34. PMID: 18066039.
    Citations: 97     Fields:    Translation:Humans
  69. Xu C, Sui J, Tao H, Zhu Q, Marasco WA. Human anti-CXCR4 antibodies undergo VH replacement, exhibit functional V-region sulfation, and define CXCR4 antigenic heterogeneity. J Immunol. 2007 Aug 15; 179(4):2408-18. PMID: 17675502.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  70. Li W, Sui J, Huang IC, Kuhn JH, Radoshitzky SR, Marasco WA, Choe H, Farzan M. The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2. Virology. 2007 Oct 25; 367(2):367-74. PMID: 17631932.
    Citations: 64     Fields:    Translation:HumansCells
  71. Cheng J, Kydd AR, Nakase K, Noonan KM, Murakami A, Tao H, Dwyer M, Xu C, Zhu Q, Marasco WA. Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein. Blood. 2007 Sep 15; 110(6):2110-20. PMID: 17540846.
    Citations: 10     Fields:    Translation:HumansCells
  72. Lo A, Zhu QK and Marasco WA. . Intracellular antibodies (Intrabodies) as specific molecules for therapeutic applications. In Handbook of Experimental Pharmacology. Chernajovsky Y, ed. 2007.
  73. Hwang WC, Lin Y, Santelli E, Sui J, Jaroszewski L, Stec B, Farzan M, Marasco WA, Liddington RC. Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. J Biol Chem. 2006 Nov 10; 281(45):34610-6. PMID: 16954221.
    Citations: 85     Fields:    Translation:HumansCells
  74. Kanai R, Kar K, Anthony K, Gould LH, Ledizet M, Fikrig E, Marasco WA, Koski RA, Modis Y. Crystal structure of west nile virus envelope glycoprotein reveals viral surface epitopes. J Virol. 2006 Nov; 80(22):11000-8. PMID: 16943291.
    Citations: 99     Fields:    Translation:Cells
  75. Bai J, Demirjian A, Sui J, Marasco W, Callery MP. Histone deacetylase inhibitor trichostatin A and proteasome inhibitor PS-341 synergistically induce apoptosis in pancreatic cancer cells. Biochem Biophys Res Commun. 2006 Oct 06; 348(4):1245-53. PMID: 16904634.
    Citations: 19     Fields:    Translation:HumansCells
  76. Yuan QA, Simmons HH, Robinson MK, Russeva M, Marasco WA, Adams GP. Development of engineered antibodies specific for the Müllerian inhibiting substance type II receptor: a promising candidate for targeted therapy of ovarian cancer. . 2006 Aug; 5(8):2096-105. PMID: 16928831.
    Citations: 11     Translation:HumansCells
  77. Marasco WA*, Sui J. . Convergent Combination Immunotherapy for the Prevention and Treatment of SARS. The 5th International Congress on Recombinant Antibodies. Zurich, Switzerland. 2006.
  78. Si Z, Vandegraaff N, O'huigin C, Song B, Yuan W, Xu C, Perron M, Li X, Marasco WA, Engelman A, Dean M, Sodroski J. Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7454-9. PMID: 16648259.
    Citations: 52     Fields:    Translation:AnimalsCells
  79. Marasco WA*, Sui J. . Passive immunotherapy in an outbreak setting. A case of SARS. From Concept to Clinic. Cambridge Health Institute’s 7th Annual Meeting, Boston, MA. 2006.
  80. Tarnovitski N, Matthews LJ, Sui J, Gershoni JM, Marasco WA. Mapping a neutralizing epitope on the SARS coronavirus spike protein: computational prediction based on affinity-selected peptides. J Mol Biol. 2006 May 26; 359(1):190-201. PMID: 16630634.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  81. Sui J and Marasco WA. . Immunopathogenesis and Immunotherapy of SARS. In Challenges of Severe Acute Respiratory Syndrome. Chan JCK and Wong VCW, eds. 2006.
  82. Sui J, Aird DR, Marasco WA*. . Human neutralizing antibodies for convergent immunotherapy against SARS. 16th Annual International Conference on Antibody Engineering, San Diego, CA. 2005.
  83. Gould LH, Sui J, Foellmer H, Oliphant T, Wang T, Ledizet M, Murakami A, Noonan K, Lambeth C, Kar K, Anderson JF, de Silva AM, Diamond MS, Koski RA, Marasco WA, Fikrig E. Protective and therapeutic capacity of human single-chain Fv-Fc fusion proteins against West Nile virus. J Virol. 2005 Dec; 79(23):14606-13. PMID: 16282460.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  84. Marasco WA*. . A strategy to move potent neutralizing anti-SARS monoclonal antibodies into clinical trials in an outbreak setting. The Second China International Symposium on Antibody Engineering. Invited Speaker. Therapeutic Antibodies for Non-Malignant Diseases. Beijing, China,. 2005.
  85. Marasco WA*, Sui J. . A Strategy Toward Convergent Combination Immunotherapy for SARS. ICLAS-CALAS International Symposium. Animal Models of Infectious Diseases. Beijing, China. 2005.
  86. Lo AS-Y, Dwyer MR, Appleman LJ, Marasco WA*. . Development of Renal Cell Carcinoma (RCC) Vaccine against G250 by Co-Expression of G250 Extracellular Domain-Fc Fusion Protein and IL-2 Using 2A Self-Processing Peptide. CHI Conference. Cancer Immunotheerptics and Targeted Cancer Therapies, Boston, MA. 2005.
  87. Marasco, WA*, Cheng J, and Noonan K. . Role of HTLV-1 Tax in SH2-containing Tyrosine Phosphatase-1 (SHP-1) Promoter Silencing in Acute Infection and Adult T-Cell Leukemia. 12th International Conference on Human Retrovirology: HTLV-1 and Related Viruses. Montego Bay, Jamaica. 2005.
  88. Cheng J, Noonan K and Marasco WA*. . Suppresses Shp-1 (SH2-containing Tyrosine Phosphatase-1) Gene Expression and Facilitates Leukemogenesis Through Tax-Promoter Interaction. 12th International Conference on Human Retrovirology: HTLV-1 and Related Viruses. Montego Bay, Jamaica. 2005.
  89. Bal HP, Cheng J, Murakami A, Tallarico AS, Wang W, Zhou D, Vasicek TJ, Marasco WA. GITR overexpression on CD4+CD25+ HTLV-1 transformed cells: detection by massively parallel signature sequencing. Biochem Biophys Res Commun. 2005 Jul 01; 332(2):569-84. PMID: 15896717.
    Citations: 5     Fields:    Translation:HumansCells
  90. Qin C, Wang J, Wei Q, She M, Marasco WA, Jiang H, Tu X, Zhu H, Ren L, Gao H, Guo L, Huang L, Yang R, Cong Z, Guo L, Wang Y, Liu Y, Sun Y, Duan S, Qu J, Chen L, Tong W, Ruan L, Liu P, Zhang H, Zhang J, Zhang H, Liu D, Liu Q, Hong T, He W. An animal model of SARS produced by infection of Macaca mulatta with SARS coronavirus. J Pathol. 2005 Jul; 206(3):251-9. PMID: 15892035.
    Citations: 41     Fields:    Translation:AnimalsCells
  91. Song E, Zhu P, Lee SK, Chowdhury D, Kussman S, Dykxhoorn DM, Feng Y, Palliser D, Weiner DB, Shankar P, Marasco WA, Lieberman J. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol. 2005 Jun; 23(6):709-17. PMID: 15908939.
    Citations: 266     Fields:    Translation:HumansAnimalsCells
  92. Marasco WA. Therapeutic antibody gene transfer. Nat Biotechnol. 2005 May; 23(5):551-2. PMID: 15877069.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  93. Sui J, Li W, Roberts A, Matthews LJ, Murakami A, Vogel L, Wong SK, Subbarao K, Farzan M, Marasco WA. Evaluation of human monoclonal antibody 80R for immunoprophylaxis of severe acute respiratory syndrome by an animal study, epitope mapping, and analysis of spike variants. J Virol. 2005 May; 79(10):5900-6. PMID: 15857975.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  94. Li W, Zhang C, Sui J, Kuhn JH, Moore MJ, Luo S, Wong SK, Huang IC, Xu K, Vasilieva N, Murakami A, He Y, Marasco WA, Guan Y, Choe H, Farzan M. Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2. EMBO J. 2005 Apr 20; 24(8):1634-43. PMID: 15791205.
    Citations: 345     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  95. Bai J, Sui J, Demirjian A, Vollmer CM, Marasco W, Callery MP. Predominant Bcl-XL knockdown disables antiapoptotic mechanisms: tumor necrosis factor-related apoptosis-inducing ligand-based triple chemotherapy overcomes chemoresistance in pancreatic cancer cells in vitro. Cancer Res. 2005 Mar 15; 65(6):2344-52. PMID: 15781649.
    Citations: 55     Fields:    Translation:HumansCells
  96. Cheng J, Kydd A, Noonan K, Xu C, Murakami A, and Marasco WA*. . Role of SHP-1 deregulation in HTLV-1 leukemogenesis. 12th Conference on Retroviruses and Opportunistic Infections, Boston, MA. 2005.
  97. Marasco, WA*, Sui J, Xu C, Murakami A and Noonan K. . Potential Use of Human Monoclonal Antibodies Against CXCR4 for the Prevention and Treatment of Breast Cancer Metastasis. Keystone Symposium on Antibody Based Therapeutics for Cancer, Santa Fe, NM. 2005.
  98. Masiero S, Del Vecchio C, Gavioli R, Mattiuzzo G, Cusi MG, Micheli L, Gennari F, Siccardi A, Marasco WA, Palù G, Parolin C. T-cell engineering by a chimeric T-cell receptor with antibody-type specificity for the HIV-1 gp120. Gene Ther. 2005 Feb; 12(4):299-310. PMID: 15496956.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  99. Marasco WA*. . A strategy for Global Collaborations to Develop Human Monoclonal Antibody (mAb) Drugs for the Treatment of Cancer. Oncology Research. 2005; 15:458.
  100. Gould LH, Sui J, Ledizet M, Foellmer H, Koski R, Marasco WA*, and Fikrig E. . Preventive and therapeutic immunization against lethal murine West Nile virus infection with a bivalent human single-chain antibody (scFv)-Fc fusion protein and rabbit polyclonal antibody against the envelope protein. American Association of Tropical Medicine and Hygiene Annual Meeting, Miami Beach, FL. 2004.
  101. Gennari F, Lopes L, Marasco WA* and Collins MK. . Targeting Dendritic Cells: Selection of Single Chain Antibodies from a Human Phage Display Library. The 12th Annual Congress of the European Society of Gene Therapy, Tampere, Finland. 2004.
  102. Busch A, Marasco WA, Doebis C, Volk HD, Seifert M. MHC class I manipulation on cell surfaces by gene transfer of anti-MHC class I intrabodies--a tool for decreased immunogenicity of allogeneic tissue and cell transplants. Methods. 2004 Oct; 34(2):240-9. PMID: 15312677.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  103. Sui J, Xu C, Murakami A, Noonan K and Marasco WA*. . Isolation of human antibodies against CXCR4 by paramagnetic proteoliposomes for prevention and treatment of breast cancer metastases. The Susan G, Komen Cancer Foundation Pathways to a Promise. New York, NY. 2004.
  104. Bal HP, Cheng J, Murakami A, Wang W, Vasicek TJ, and Marasco WA*. . Transcriptional deregulation in adult T-cell leukemia: Genome-wide transcriptional profiling of acutely HTLV-1 transformed cells using Massively Parallel Signature Sequencing. 95th AACR Annual Meeting, Orlando, FL. 2004.
  105. Sui J, Li W, Murakami A, Tamin A, Matthews LJ, Wong SK, Moore MJ, Tallarico AS, Olurinde M, Choe H, Anderson LJ, Bellini WJ, Farzan M, Marasco WA. Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2536-41. PMID: 14983044.
    Citations: 213     Fields:    Translation:HumansCells
  106. Cheng JD, Valianou M, Simmons H, Jann P, Yuan QA, Russeva MG, Marasco WA*, Cukierman E, Adams GP, and Weiner LM. Abrogation of Fibroblast Activation Protein Enzymatic Activity Attenuates Tumor Growth. AACR Annual Meeting, Dana Point, CA. 2004.
  107. Cheng J, Kydd A, Noonan K, Xu C, Murakami A, and Marasco WA*. . Role of SHP-1 deregulation in HTLV-1 leukemogenesis. 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, CA. 2004.
  108. Gennari F, Mehta S, Wang Y, St Clair Tallarico A, Palu G, Marasco WA. Direct phage to intrabody screening (DPIS): demonstration by isolation of cytosolic intrabodies against the TES1 site of Epstein Barr virus latent membrane protein 1 (LMP1) that block NF-kappaB transactivation. J Mol Biol. 2004 Jan 02; 335(1):193-207. PMID: 14659750.
    Citations: 9     Fields:    Translation:HumansCells
  109. Cheng J, Zhang D, Zhou C, Marasco WA. Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells. Leuk Res. 2004 Jan; 28(1):71-82. PMID: 14630083.
    Citations: 10     Fields:    Translation:HumansCells
  110. Sui J, Bai J, St Clair Tallarico A, Xu C, Marasco WA. Identification of CD4 and transferrin receptor antibodies by CXCR4 antibody-guided Pathfinder selection. Eur J Biochem. 2003 Nov; 270(22):4497-506. PMID: 14622278.
    Citations: 6     Fields:    Translation:HumansCells
  111. Vyas J and Marasco WA*. . Fatal Fulminant Hepatic Failure from Adenovirus in Allogeneic Bone Marrow Transplant Patients. 41st Annual Meeting of Infectious Diseases Society of America. 2003.
  112. Marty FM, Cosimi L, Marasco WA*, Rubin RH and Baden LR. . Breakthrough Zygomycosis in Allogeneic Hematopoietic Stem Cell Transplant Recipients Who Received Voriconazole as Prophylaxis or Empiric Therapy. 43rd ICAAC. 2003.
  113. Xu C, Kontos H, Tallarico A, Murakami A, Morse LJ, Cheng J and Marasco WA*. . Generation and Characterization of Engineered Human Anti-CCR5 Antibodies. 3rd Annual Harvard Medical School Centers for AIDS Research Symposium, Boston, MA. 2003.
  114. Cheng J, Zhang D, Zhou C and Marasco WA*. . Down-Regulation of SHP1 and Up-Regulation of Negative Regulators of JAK/STAT Signaling in HTLV-1 Transformed Cell Lines and Freshly Transformed Human Peripheral Blood CD4+ T-cells. 3rd Annual Harvard Medical School Centers for AIDS Research Symposium, Boston, MA. 2003.
  115. Zhang D, Murakami A, Johnson RP, Sui J, Cheng J, Bai J, Marasco WA. Optimization of ex vivo activation and expansion of macaque primary CD4-enriched peripheral blood mononuclear cells for use in anti-HIV immunotherapy and gene therapy strategies. . 2003 Mar 01; 32(3):245-54. PMID: 12626883.
    Citations: 5     Translation:AnimalsCells
  116. Marasco WA*, Murakami A, Gennari F. . Intrabodies as Tools to Perturb Cellular Function. Guest Speaker for the Antibody-Based Therapeutics for Cancer, 2003 Keystone Symposia. 2003.
  117. Zhu Q and Marasco WA. . Intracellular targeting of antibodies in mammalian cells. In New Comprehensive Biocehmistry : Gene Transfer and Expression in Mammalian Cells. Savvas C. Makrides , ed. 2003; 573 – 623.
  118. Sui J, Marasco WA. Evidence against Ebola virus sGP binding to human neutrophils by a specific receptor. Virology. 2002 Nov 10; 303(1):9-14. PMID: 12482654.
    Citations: 9     Fields:    Translation:HumansCells
  119. Bai J, Sui J, Zhu RY, Tallarico AS, Gennari F, Zhang D, Marasco WA. Inhibition of Tat-mediated transactivation and HIV-1 replication by human anti-hCyclinT1 intrabodies. J Biol Chem. 2003 Jan 17; 278(3):1433-42. PMID: 12401780.
    Citations: 25     Fields:    Translation:HumansCells
  120. Mhashilkar AM, Doebis C, Seifert M, Busch A, Zani C, Soo Hoo J, Nagy M, Ritter T, Volk HD, Marasco WA. Intrabody-mediated phenotypic knockout of major histocompatibility complex class I expression in human and monkey cell lines and in primary human keratinocytes. Gene Ther. 2002 Mar; 9(5):307-19. PMID: 11938450.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  121. Li X, Josef J, Marasco WA. Hiv-1 Tat can substantially enhance the capacity of NIK to induce IkappaB degradation. Biochem Biophys Res Commun. 2001 Aug 24; 286(3):587-94. PMID: 11511100.
    Citations: 2     Fields:    Translation:HumansCells
  122. Ogueta SB, Yao F, Marasco WA. Design and in vitro characterization of a single regulatory module for efficient control of gene expression in both plasmid DNA and a self-inactivating lentiviral vector. Mol Med. 2001 Aug; 7(8):569-79. PMID: 11591893.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  123. Li X, Stuckert P, Bosch I, Marks JD, Marasco WA. Single-chain antibody-mediated gene delivery into ErbB2-positive human breast cancer cells. Cancer Gene Ther. 2001 Aug; 8(8):555-65. PMID: 11571533.
    Citations: 18     Fields:    Translation:HumansCells
  124. Marasco WA. Intrabodies as antiviral agents. Curr Top Microbiol Immunol. 2001; 260:247-70. PMID: 11443877.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  125. Marasco WA. . Intrabodies as anti-viral agents. In Current Topics in Microbiology and Immunology. Dennis R. Burton,ed. 2001; 260:247-70.
  126. Marasco, WA. Expression vectors and methods of use. 2000.
  127. Li X, Multon MC, Henin Y, Schweighoffer F, Venot C, Josef J, Zhou C, LaVecchio J, Stuckert P, Raab M, Mhashilkar A, Tocque B, Marasco WA. Grb3-3 is up-regulated in HIV-1-infected T-cells and can potentiate cell activation through NFATc. J Biol Chem. 2000 Oct 06; 275(40):30925-33. PMID: 10906142.
    Citations: 3     Fields:    Translation:HumansCells
  128. Li X, Multon MC, Henin Y, Schweighoffer F, Venot C, LaVecchio J, Josef J, Stuckert P, Mhashilkar A, Tocqué B, Marasco WA. Upregulation of the apoptosis-associated protein Grb3-3 in HIV-1-infected human CD4(+) lymphocytes. Biochem Biophys Res Commun. 2000 Sep 16; 276(1):362-70. PMID: 11006130.
    Citations: 2     Fields:    Translation:HumansCells
  129. Marasco, WA. Method of intracellular binding of target molecules. 2000.
  130. Mirzabekov T, Kontos H, Farzan M, Marasco W, Sodroski J. Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5. Nat Biotechnol. 2000 Jun; 18(6):649-54. PMID: 10835604.
    Citations: 36     Fields:    Translation:HumansCells
  131. Song SU and Marasco WA. . Rapid establishment of myeloma cell lines expressing Fab (Tac)-Protamine, A targetable protein vector, directed against the high affinity alpha chain of the human interleukin-2 receptor. In Methods in Molecular Biology. Eric Kmiec, ed. 2000; 133:156-66.
  132. Song SU, Marasco WA. Rapid establishment of myeloma cell lines expressing Fab(Tac)-protamine, a targetable protein vector, directed against high-affinity alpha-chain of human interleukin-2 receptor. Methods Mol Biol. 2000; 133:157-66. PMID: 10561837.
    Citations:    Fields:    Translation:HumansAnimalsCells
  133. Marasco, WA. Intracellular targeting of endogenous proteins. 1999.
  134. Marasco WA, LaVecchio J, Winkler A. Human anti-HIV-1 tat sFv intrabodies for gene therapy of advanced HIV-1-infection and AIDS. J Immunol Methods. 1999 Dec 10; 231(1-2):223-38. PMID: 10648940.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  135. Zhu Q, Zeng C, Huhalov A, Yao J, Turi TG, Danley D, Hynes T, Cong Y, DiMattia D, Kennedy S, Daumy G, Schaeffer E, Marasco WA, Huston JS. Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7. J Immunol Methods. 1999 Dec 10; 231(1-2):207-22. PMID: 10648939.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  136. Poznansky MC, La Vecchio J, Silva-Arietta S, Porter-Brooks J, Brody K, Olszak IT, Adams GB, Ramstedt U, Marasco WA, Scadden DT. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and monocytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat. Hum Gene Ther. 1999 Oct 10; 10(15):2505-14. PMID: 10543615.
    Citations: 4     Fields:    Translation:HumansCells
  137. Mhashilkar AM, LaVecchio J, Eberhardt B, Porter-Brooks J, Boisot S, Dove JH, Pumphrey C, Li X, Weissmahr RN, Ring DB, Ramstedt U, Marasco WA. Inhibition of human immunodeficiency virus type 1 replication in vitro in acutely and persistently infected human CD4+ mononuclear cells expressing murine and humanized anti-human immunodeficiency virus type 1 Tat single-chain variable fragment intrabodies. Hum Gene Ther. 1999 Jun 10; 10(9):1453-67. PMID: 10395371.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  138. Marasco, WA. Reactive neutralizing human anti-gp120 recombinant antibody, DNA coding the same and use thereof. 1998.
  139. Marasco, WA. Method of intracellular binding of target molecules. 1998.
  140. Marasco, WA. Method of intracellular binding of target molecules. 1998.
  141. Marasco WA, Chen S, Richardson JH, Ramstedt U, Jones SD. Intracellular antibodies against HIV-1 envelope protein for AIDS gene therapy. Hum Gene Ther. 1998 Jul 20; 9(11):1627-42. PMID: 9694161.
    Citations: 7     Fields:    Translation:HumansCells
  142. Richardson JH, Hofmann W, Sodroski JG, Marasco WA. Intrabody-mediated knockout of the high-affinity IL-2 receptor in primary human T cells using a bicistronic lentivirus vector. Gene Ther. 1998 May; 5(5):635-44. PMID: 9797868.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  143. Marasco WA. Antibodies for targeted gene therapy: extracellular gene targeting and intracellular expression. Adv Drug Deliv Rev. 1998 Apr 06; 31(1-2):153-170. PMID: 10837623.
    Citations: 5     Fields:    
  144. Pumphrey CY, Marasco WA. The therapeutic potential of intracellular antibodies. BioDrugs. 1998 Mar; 9(3):179-85. PMID: 18020558.
    Citations:    Fields:    
  145. Poznansky MC, Foxall R, Mhashilkar A, Coker R, Jones S, Ramstedt U, Marasco W. Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells from HIV-infected individuals that express intracellular antibodies against HIV-1 gp120 or Tat. Hum Gene Ther. 1998 Mar 01; 9(4):487-96. PMID: 9525310.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  146. Vallat AV, De Girolami U, He J, Mhashilkar A, Marasco W, Shi B, Gray F, Bell J, Keohane C, Smith TW, Gabuzda D. Localization of HIV-1 co-receptors CCR5 and CXCR4 in the brain of children with AIDS. Am J Pathol. 1998 Jan; 152(1):167-78. PMID: 9422534.
    Citations: 48     Fields:    Translation:HumansCells
  147. Jones SD and Marasco WA. . Antibodies for targeted gene therapy: extracellular gene targeting and intracellular expression. In Advanced Drug Reviews. 1998; 31:153-170.
  148. Richardson JH, Waldmann TA, Sodroski JG, Marasco WA. Inducible knockout of the interleukin-2 receptor alpha chain: expression of the high-affinity IL-2 receptor is not required for the in vitro growth of HTLV-I-transformed cell lines. Virology. 1997 Oct 27; 237(2):209-16. PMID: 9356333.
    Citations: 5     Fields:    Translation:HumansCells
  149. Mhashilkar AM, Biswas DK, LaVecchio J, Pardee AB, Marasco WA. Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-Tat single-chain intrabodies and NF-kappa B antagonists. J Virol. 1997 Sep; 71(9):6486-94. PMID: 9261367.
    Citations: 14     Fields:    Translation:HumansCells
  150. Levin R, Mhashilkar AM, Dorfman T, Bukovsky A, Zani C, Bagley J, Hinkula J, Niedrig M, Albert J, Wahren B, Göttlinger HG, Marasco WA. Inhibition of early and late events of the HIV-1 replication cycle by cytoplasmic Fab intrabodies against the matrix protein, p17. Mol Med. 1997 Feb; 3(2):96-110. PMID: 9085253.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  151. Rondon IJ and Marasco WA. . Gene therapy for HIV-1 using intracellular antibodies against HIV-1 Gag proteins. In Intrabodies: Basic Research and Clinical Gene Therapy Applications. Molecular Biology Intelligence Unit. Marasco WA, ed. 1997.
  152. Marasco WA. . Intrabodies: From antibody genes to intracellular immunization. In The Antibodies, Zanetti M and Capra JD, eds. 1997; 4.
  153. Marasco WA. . Designing Intrabodies: Structural features and the use of intracellular trafficking signals. In Intrabodies: Basic Research and Clinical Gene Therapy Applications. Molecular Biology Intelligence Unit. Marasco WA, ed. 1997.
  154. Marasco WA. Intrabodies: turning the humoral immune system outside in for intracellular immunization. Gene Ther. 1997 Jan; 4(1):11-5. PMID: 9068790.
    Citations: 16     Fields:    Translation:Humans
  155. Richardson JH and Marasco WA. . Studies on the phenotypic ¡§knockout¡¨ of the human interleukin-2 receptor ƒÑ chain. In Intrabodies: Basic Research and Clinical Gene Therapy Applications. Molecular Biology Intelligence Unit. Marasco WA, ed. 1997.
  156. Pumphrey CY and Marasco WA. . The therapeutic potential of intracellular antibodies. In BioDrugs. Beedle AS, ed. 1997.
  157. Jones SD and Marasco WA. . Intracellular antibodies (intrabodies): Potential applications in transgenic animal research and engineered resistance to pathogens. In Transgenic Animals - Generation and Use. Houdebine L-M, ed. . 1997; 74:501-6.
  158. Rondon IJ, Marasco WA. Intracellular antibodies (intrabodies) for gene therapy of infectious diseases. Annu Rev Microbiol. 1997; 51:257-83. PMID: 9343351.
    Citations: 24     Fields:    Translation:HumansCells
  159. Mhashilkar AM and Marasco WA. . Intrabodies targeted against regulatory epitopes of HIV-1: Tat and Rev as two significant targets for gene therapy. In Intrabodies: Basic Research and Clinical Gene Therapy Applications. Molecular Biology Intelligence Unit. Marasco WA, ed. 1997.
  160. Chen JD, Yang Q, Yang AG, Marasco WA, Chen SY. Intra- and extracellular immunization against HIV-1 infection with lymphocytes transduced with an AAV vector expressing a human anti-gp120 antibody. Hum Gene Ther. 1996 Aug 20; 7(13):1515-25. PMID: 8864752.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
  161. Chen SY, Marasco WA. Novel genetic immunotoxins and intracellular antibodies for cancer therapy. Semin Oncol. 1996 Feb; 23(1):148-53. PMID: 8607024.
    Citations:    Fields:    Translation:Humans
  162. Marasco WA. . Gene Therapy and Research Applications of Intrabodies for Human Infectious Diseases. In The Use of Ectopic Antibody Expression for Intracellular and Extracellular Immunization. Biocca S. And Cattaneo A., eds. 1996.
  163. Mhashilkar AM, Agarwal S, Levin R, and Marasco WA. . Looking ahead: Combination of intracellular single-chain antibodies and other genetic-based anti-HIV-1 approaches hold promise as an effective strategy for AIDS gene therapy. In Drugs, News and Perspectives. 1996; 9:220-7.
  164. Mhashilkar AM and Marasco WA. . Intrabody-based gene therapy approaches against HIV-1. In -Advancing a New Agenda for AIDS Research, Poznansky M.C., Coker R.J. and Gilles P., eds. 1996.
  165. Richardson JH, Marasco WA. Intracellular antibodies: development and therapeutic potential. Trends Biotechnol. 1995 Aug; 13(8):306-10. PMID: 7662306.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  166. Marasco WA. Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy. Immunotechnology. 1995 May; 1(1):1-19. PMID: 9373329.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  167. Richardson JH, Sodroski JG, Waldmann TA, Marasco WA. Phenotypic knockout of the high-affinity human interleukin 2 receptor by intracellular single-chain antibodies against the alpha subunit of the receptor. Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3137-41. PMID: 7724529.
    Citations: 14     Fields:    Translation:HumansCells
  168. Mhashilkar AM, Bagley J, Chen SY, Szilvay AM, Helland DG, Marasco WA. Inhibition of HIV-1 Tat-mediated LTR transactivation and HIV-1 infection by anti-Tat single chain intrabodies. EMBO J. 1995 Apr 03; 14(7):1542-51. PMID: 7537216.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  169. Chen SY, Zani C, Khouri Y, Marasco WA. Design of a genetic immunotoxin to eliminate toxin immunogenicity. Gene Ther. 1995 Mar; 2(2):116-23. PMID: 7719928.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  170. Khouri YF, McIntosh K, Cavacini L, Posner M, Pagano M, Tuomala R, Marasco WA. Vertical Transmission of HIV-1. Correlation with maternal viral load and plasma levels of CD4 binding site anti-gp120 antibodies. J Clin Invest. 1995 Feb; 95(2):732-7. PMID: 7860754.
    Citations: 11     Fields:    Translation:HumansCellsCTClinical Trials
  171. Becker EL and Marasco WA.* . Chemotaxis and activation of neutrophils. In Symposium on Chemical Mediators of Inflammation. Japan, Cohen S, Hayashi H, Saito K, and Takada A. eds. 1995; 220-4.
  172. Chen S-Y, Mhashilkar AM, and Marasco WA. . Intracellular antibodies for HIV-1 gene therapy. In Expert Opinion on Investigational Drugs. 1995; 4:823-31.
  173. Smith C, Marasco WA, and Böhnlein B. . Gene therapy. In HIV: A Practical Approach: Volume 2, Biochemistry, Molecular Biology, Drug Discovery. Karn J, ed. 1995.
  174. Bagley J, Dillon PJ, Rosen C, Robinson J, Sodroski J, Marasco WA. Structural characterization of broadly neutralizing human monoclonal antibodies against the CD4 binding site of HIV-1 gp120. Mol Immunol. 1994 Oct; 31(15):1149-60. PMID: 7935503.
    Citations: 10     Fields:    Translation:HumansCells
  175. Chen SY, Khouri Y, Bagley J, Marasco WA. Combined intra- and extracellular immunization against human immunodeficiency virus type 1 infection with a human anti-gp120 antibody. Proc Natl Acad Sci U S A. 1994 Jun 21; 91(13):5932-6. PMID: 8016092.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  176. Chen SY, Bagley J, Marasco WA. Intracellular antibodies as a new class of therapeutic molecules for gene therapy. Hum Gene Ther. 1994 May; 5(5):595-601. PMID: 7914435.
    Citations: 25     Fields:    Translation:HumansCells
  177. Marasco WA, Szilvay AM, Kalland KH, Helland DG, Reyes HM, Walter RJ. Spatial association of HIV-1 tat protein and the nucleolar transport protein B23 in stably transfected Jurkat T-cells. Arch Virol. 1994; 139(1-2):133-54. PMID: 7826206.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  178. Marasco WA, Haseltine WA, Chen SY. Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7889-93. PMID: 8356098.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  179. Marasco WA, Bagley J, Zani C, Posner M, Cavacini L, Haseltine WA, Sodroski J. Characterization of the cDNA of a broadly reactive neutralizing human anti-gp120 monoclonal antibody. J Clin Invest. 1992 Oct; 90(4):1467-78. PMID: 1401079.
    Citations: 15     Fields:    Translation:HumansCells
  180. Garcia LW, Hemphill RB, Marasco WA, Ciano PS. Acquired immunodeficiency syndrome with disseminated toxoplasmosis presenting as an acute pulmonary and gastrointestinal illness. Arch Pathol Lab Med. 1991 May; 115(5):459-63. PMID: 2021313.
    Citations: 2     Fields:    Translation:Humans
  181. Bradley SF, Gordon JJ, Baumgartner DD, Marasco WA, Kauffman CA. Group C streptococcal bacteremia: analysis of 88 cases. Rev Infect Dis. 1991 Mar-Apr; 13(2):270-80. PMID: 2041960.
    Citations: 37     Fields:    Translation:Humans
  182. Sannomiya P, Craig RA, Clewell DB, Suzuki A, Fujino M, Till GO, Marasco WA. Characterization of a class of nonformylated Enterococcus faecalis-derived neutrophil chemotactic peptides: the sex pheromones. Proc Natl Acad Sci U S A. 1990 Jan; 87(1):66-70. PMID: 2104986.
    Citations: 16     Fields:    Translation:AnimalsCells
  183. Marasco WA, Lester S, Parsonnet J. Unusual presentation of cat scratch disease in a patient positive for antibody to the human immunodeficiency virus. Rev Infect Dis. 1989 Sep-Oct; 11(5):793-803. PMID: 2814165.
    Citations: 3     Fields:    Translation:Humans
  184. Janeczek AH, Marasco WA, van Alten PJ, Walter RJ. Autoradiographic analysis of formylpeptide chemoattractant binding, uptake and intracellular processing by neutrophils. J Cell Sci. 1989 Sep; 94 ( Pt 1):155-68. PMID: 2515197.
    Citations: 4     Fields:    Translation:AnimalsCells
  185. Feltner DE, Marasco WA. Regulation of formyl peptide receptor binding to rabbit neutrophil plasma membranes. Use of monovalent cations, guanine nucleotides, and bacterial toxins to discriminate among different states of the receptor. J Immunol. 1989 Jun 01; 142(11):3963-70. PMID: 2715641.
    Citations: 3     Fields:    Translation:AnimalsCells
  186. Atkinson YH, Lopez AF, Marasco WA, Lucas CM, Wong GG, Burns GF, Vadas MA. Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils. Immunology. 1988 Jul; 64(3):519-25. PMID: 2842255.
    Citations: 17     Fields:    Translation:HumansCells
  187. Atkinson YH, Marasco WA, Lopez AF, Vadas MA. Recombinant human tumor necrosis factor-alpha. Regulation of N-formylmethionylleucylphenylalanine receptor affinity and function on human neutrophils. J Clin Invest. 1988 Mar; 81(3):759-65. PMID: 2830314.
    Citations: 42     Fields:    Translation:HumansCells
  188. Marasco WA and Ward PA. . Chemotactic factors of bacterial origin. Chapter 19. In Immunological Techniques. Part L. Chemotaxis and Inflammation. Methods in Enzymology. DiSabato G, Langone JJ, and VanVunakis H, eds. 1988; Vol. 162:198-214.
  189. Marasco WA, Ward PA. Chemotactic factors of bacterial origin. Methods Enzymol. 1988; 162:198-214. PMID: 3067051.
    Citations: 2     Fields:    Translation:AnimalsCells
  190. Marasco WA, Gikas PW, Azziz-Baumgartner R, Hyzy R, Eldredge CJ, Stross J. Ibuprofen-associated renal dysfunction. Pathophysiologic mechanisms of acute renal failure, hyperkalemia, tubular necrosis, and proteinuria. Arch Intern Med. 1987 Dec; 147(12):2107-16. PMID: 3689062.
    Citations: 7     Fields:    Translation:Humans
  191. Walter RJ, Marasco WA. Direct visualization of formylpeptide receptor binding on rounded and polarized human neutrophils: cellular and receptor heterogeneity. J Leukoc Biol. 1987 May; 41(5):377-91. PMID: 3553401.
    Citations: 3     Fields:    Translation:HumansCells
  192. Walter RJ and Marasco WA. . Heterogeneity and topographical asymmetry of formyl peptide receptor binding on polymorphonuclear leukocytes. In The Biology of Phagocytes in Health and Disease. Mauri C, Rizzo SC, and Ricevuti G, eds. 1987; 9-21.
  193. Feltner DE, Smith RH, Marasco WA. Characterization of the plasma membrane bound GTPase from rabbit neutrophils. I. Evidence for an Ni-like protein coupled to the formyl peptide, C5a, and leukotriene B4 chemotaxis receptors. J Immunol. 1986 Sep 15; 137(6):1961-70. PMID: 3018082.
    Citations: 11     Fields:    Translation:AnimalsCells
  194. Duque RE, Fantone JC, Kramer C, Marasco WA, Phan SH. Inhibition of neutrophil activation by p-bromophenacyl bromide and its effects on phospholipase A2. Br J Pharmacol. 1986 Jun; 88(2):463-72. PMID: 3015312.
    Citations: 4     Fields:    Translation:AnimalsCells
  195. Marasco WA, Becker KM, Feltner DE, Brown CS, Ward PA, Nairn R. Covalent affinity labeling, detergent solubilization, and fluid-phase characterization of the rabbit neutrophil formyl peptide chemotaxis receptor. Biochemistry. 1985 Apr 23; 24(9):2227-36. PMID: 3995012.
    Citations: 5     Fields:    Translation: