Harvard Catalyst Profiles

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Monica P. Colaiacovo, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13HD095645 (COLAIACOVO, MONICA P) Mar 21, 2018 - Aug 1, 2018
    2018 Meiosis Gordon Research Conference & Gordon Research Seminar
    Role: Principal Investigator
  2. R01GM105853 (COLAIACOVO, MONICA P) Jul 15, 2014 - Feb 28, 2018
    Molecular mechanisms of germline DNA repair and DNA damage response
    Role: Principal Investigator
  3. R01GM072551 (COLAIACOVO, MONICA P) Aug 1, 2005 - Jul 31, 2023
    Synaptonemal complex assembly and function in meiosis
    Role: Principal Investigator
  4. F32HD041329 (COLAIACOVO, MONICA P) Jul 1, 2001 - Aug 31, 2003
    Studies of Synaptonemal Complex in C. elegans Meiosis
    Role: Principal Investigator
  5. F31GM018050 (COLAIACOVO, MONICA P) Mar 25, 1996
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li Q, Saito TT, Martinez-Garcia M, Deshong AJ, Nadarajan S, Lawrence KS, Checchi PM, Colaiacovo MP, Engebrecht J. The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans. PLoS Genet. 2018 11; 14(11):e1007701. PMID: 30383767.
    Citations:    Fields:    
  2. Nottke AC, Kim HM, Colaiácovo MP. Wrestling with Chromosomes: The Roles of SUMO During Meiosis. Adv Exp Med Biol. 2017; 963:185-196. PMID: 28197913.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. Addendum: REST and stress resistance in ageing and Alzheimer's disease. Nature. 2016 12 15; 540(7633):470. PMID: 27851730.
    Citations: 1     Fields:    
  4. Gao J, Barroso C, Zhang P, Kim HM, Li S, Labrador L, Lightfoot J, Gerashchenko MV, Labunskyy VM, Dong MQ, Martinez-Perez E, Colaiácovo MP. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Genes Dev. 2016 11 01; 30(21):2404-2416. PMID: 27881602.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Kim HM, Colaiácovo MP. CRISPR-Cas9-Guided Genome Engineering in C. elegans. Curr Protoc Mol Biol. 2016 07 01; 115:31.7.1-31.7.18. PMID: 27366893.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Mendes TK, Novakovic S, Raymant G, Bertram SE, Esmaillie R, Nadarajan S, Breugelmans B, Hofmann A, Gasser RB, Colaiácovo MP, Boag PR. Correction: Investigating the Role of RIO Protein Kinases in Caenorhabditis elegans. PLoS One. 2016; 11(5):e0156191. PMID: 27192152.
    Citations:    Fields:    
  7. Nadarajan S, Mohideen F, Tzur YB, Ferrandiz N, Crawley O, Montoya A, Faull P, Snijders AP, Cutillas PR, Jambhekar A, Blower MD, Martinez-Perez E, Harper JW, Colaiacovo MP. The MAP kinase pathway coordinates crossover designation with disassembly of synaptonemal complex proteins during meiosis. Elife. 2016 Feb 27; 5:e12039. PMID: 26920220.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Norris AD, Kim HM, Colaiácovo MP, Calarco JA. Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual-Marker Selection Cassettes. Genetics. 2015 Oct; 201(2):449-58. PMID: 26232410.
    Citations: 24     Fields:    Translation:AnimalsCells
  9. Kim HM, Colaiácovo MP. DNA Damage Sensitivity Assays in Caenorhabditis elegans. Bio Protoc. 2015; 5(11). PMID: 26807430.
    Citations: 2     
  10. Kim HM, Colaiácovo MP. New Insights into the Post-Translational Regulation of DNA Damage Response and Double-Strand Break Repair in Caenorhabditis elegans. Genetics. 2015 Jun; 200(2):495-504. PMID: 25819793.
    Citations: 5     Fields:    Translation:AnimalsCells
  11. Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. PLoS Genet. 2015 Mar; 11(3):e1005029. PMID: 25768301.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Mendes TK, Novakovic S, Raymant G, Bertram SE, Esmaillie R, Nadarajan S, Breugelmans B, Hofmann A, Gasser RB, Colaiácovo MP, Boag PR. Investigating the role of RIO protein kinases in Caenorhabditis elegans. PLoS One. 2015; 10(2):e0117444. PMID: 25688864.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Kim HM, Colaiácovo MP. ZTF-8 interacts with the 9-1-1 complex and is required for DNA damage response and double-strand break repair in the C. elegans germline. PLoS Genet. 2014 Oct; 10(10):e1004723. PMID: 25329393.
    Citations: 7     Fields:    Translation:AnimalsCells
  14. Greer EL, Beese-Sims SE, Brookes E, Spadafora R, Zhu Y, Rothbart SB, Aristizábal-Corrales D, Chen S, Badeaux AI, Jin Q, Wang W, Strahl BD, Colaiácovo MP, Shi Y. A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Cell Rep. 2014 Apr 10; 7(1):113-26. PMID: 24685137.
    Citations: 32     Fields:    Translation:AnimalsCells
  15. Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM, Drake D, Liu XS, Bennett DA, Colaiácovo MP, Yankner BA. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014 Mar 27; 507(7493):448-54. PMID: 24670762.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  16. Saito TT, Colaiácovo MP. Crossover recombination mediated by HIM-18/SLX4-associated nucleases. Worm. 2014; 3:e28233. PMID: 25057454.
    Citations: 2     
  17. Tzur YB, Friedland AE, Nadarajan S, Church GM, Calarco JA, Colaiácovo MP. Heritable custom genomic modifications in Caenorhabditis elegans via a CRISPR-Cas9 system. Genetics. 2013 Nov; 195(3):1181-5. PMID: 23979579.
    Citations: 55     Fields:    Translation:AnimalsCells
  18. Saito TT, Lui DY, Kim HM, Meyer K, Colaiácovo MP. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. PLoS Genet. 2013; 9(7):e1003586. PMID: 23874210.
    Citations: 31     Fields:    Translation:AnimalsCells
  19. Friedland AE, Tzur YB, Esvelt KM, Colaiácovo MP, Church GM, Calarco JA. Heritable genome editing in C. elegans via a CRISPR-Cas9 system. Nat Methods. 2013 Aug; 10(8):741-3. PMID: 23817069.
    Citations: 276     Fields:    Translation:AnimalsCells
  20. Allard P, Kleinstreuer NC, Knudsen TB, Colaiácovo MP. A C. elegans screening platform for the rapid assessment of chemical disruption of germline function. Environ Health Perspect. 2013 Jun; 121(6):717-24. PMID: 23603051.
    Citations: 13     Fields:    Translation:AnimalsCells
  21. Clemons AM, Brockway HM, Yin Y, Kasinathan B, Butterfield YS, Jones SJ, Colaiácovo MP, Smolikove S. akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I. Mol Biol Cell. 2013 Apr; 24(7):1053-67. PMID: 23363597.
    Citations: 8     Fields:    Translation:AnimalsCells
  22. Lui DY, Colaiácovo MP. Meiotic development in Caenorhabditis elegans. Adv Exp Med Biol. 2013; 757:133-70. PMID: 22872477.
    Citations: 16     Fields:    Translation:Animals
  23. Sengupta MS, Low WY, Patterson JR, Kim HM, Traven A, Beilharz TH, Colaiácovo MP, Schisa JA, Boag PR. ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. J Cell Sci. 2013 Feb 01; 126(Pt 3):850-9. PMID: 23264733.
    Citations: 9     Fields:    Translation:AnimalsCells
  24. Saito TT, Mohideen F, Meyer K, Harper JW, Colaiácovo MP. SLX-1 is required for maintaining genomic integrity and promoting meiotic noncrossovers in the Caenorhabditis elegans germline. PLoS Genet. 2012 Aug; 8(8):e1002888. PMID: 22927825.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  25. Tzur YB, Egydio de Carvalho C, Nadarajan S, Van Bostelen I, Gu Y, Chu DS, Cheeseman IM, Colaiácovo MP. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. PLoS Biol. 2012; 10(8):e1001378. PMID: 22927794.
    Citations: 11     Fields:    Translation:AnimalsCells
  26. Schild-Prüfert K, Saito TT, Smolikov S, Gu Y, Hincapie M, Hill DE, Vidal M, McDonald K, Colaiácovo MP. Organization of the synaptonemal complex during meiosis in Caenorhabditis elegans. Genetics. 2011 Oct; 189(2):411-21. PMID: 21840865.
    Citations: 25     Fields:    Translation:AnimalsCells
  27. Nottke AC, Beese-Sims SE, Pantalena LF, Reinke V, Shi Y, Colaiácovo MP. SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair. Proc Natl Acad Sci U S A. 2011 Aug 02; 108(31):12805-10. PMID: 21768382.
    Citations: 29     Fields:    Translation:AnimalsCells
  28. Compton D, Colaiácovo MP. Advances in imaging reveal novel insights into the mechanisms promoting accurate chromosome segregation in mitosis and meiosis. Mol Biol Cell. 2011 Mar 15; 22(6):720. PMID: 21406583.
    Citations:    Fields:    Translation:HumansAnimals
  29. Saito TT, Colaiácovo MP. Break to make a connection. PLoS Genet. 2011 Feb; 7(2):e1002006. PMID: 21383860.
    Citations: 1     Fields:    Translation:HumansAnimals
  30. Allard P, Colaiácovo MP. Mechanistic insights into the action of Bisphenol A on the germline using C. elegans. Cell Cycle. 2011 Jan 15; 10(2):183-4. PMID: 21228622.
    Citations: 5     Fields:    Translation:AnimalsCells
  31. Allard P, Colaiácovo MP. Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20405-10. PMID: 21059909.
    Citations: 40     Fields:    Translation:AnimalsCells
  32. Chou DM, Adamson B, Dephoure NE, Tan X, Nottke AC, Hurov KE, Gygi SP, Colaiácovo MP, Elledge SJ. A chromatin localization screen reveals poly (ADP ribose)-regulated recruitment of the repressive polycomb and NuRD complexes to sites of DNA damage. Proc Natl Acad Sci U S A. 2010 Oct 26; 107(43):18475-80. PMID: 20937877.
    Citations: 193     Fields:    Translation:HumansAnimalsCells
  33. Smogorzewska A, Desetty R, Saito TT, Schlabach M, Lach FP, Sowa ME, Clark AB, Kunkel TA, Harper JW, Colaiácovo MP, Elledge SJ. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Mol Cell. 2010 Jul 09; 39(1):36-47. PMID: 20603073.
    Citations: 148     Fields:    Translation:HumansAnimalsCells
  34. Saito TT, Youds JL, Boulton SJ, Colaiácovo MP. Caenorhabditis elegans HIM-18/SLX-4 interacts with SLX-1 and XPF-1 and maintains genomic integrity in the germline by processing recombination intermediates. PLoS Genet. 2009 Nov; 5(11):e1000735. PMID: 19936019.
    Citations: 57     Fields:    Translation:AnimalsCells
  35. Tzur YB, Colaiácovo MP. Genetics: Crossover control in two steps. Nature. 2009 Nov 05; 462(7269):46-7. PMID: 19890320.
    Citations:    Fields:    Translation:Animals
  36. Smolikov S, Schild-Prüfert K, Colaiácovo MP. A yeast two-hybrid screen for SYP-3 interactors identifies SYP-4, a component required for synaptonemal complex assembly and chiasma formation in Caenorhabditis elegans meiosis. PLoS Genet. 2009 Oct; 5(10):e1000669. PMID: 19798442.
    Citations: 28     Fields:    Translation:AnimalsCells
  37. Martinez-Perez E, Colaiácovo MP. Distribution of meiotic recombination events: talking to your neighbors. Curr Opin Genet Dev. 2009 Apr; 19(2):105-12. PMID: 19328674.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  38. Nottke A, Colaiácovo MP, Shi Y. Developmental roles of the histone lysine demethylases. Development. 2009 Mar; 136(6):879-89. PMID: 19234061.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  39. de Carvalho CE, Zaaijer S, Smolikov S, Gu Y, Schumacher JM, Colaiácovo MP. LAB-1 antagonizes the Aurora B kinase in C. elegans. Genes Dev. 2008 Oct 15; 22(20):2869-85. PMID: 18923084.
    Citations: 38     Fields:    Translation:AnimalsCells
  40. Smolikov S, Schild-Prüfert K, Colaiácovo MP. CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis. PLoS Genet. 2008 Jun 06; 4(6):e1000088. PMID: 18535664.
    Citations: 29     Fields:    Translation:AnimalsCells
  41. Smolikov S, Eizinger A, Hurlburt A, Rogers E, Villeneuve AM, Colaiácovo MP. Synapsis-defective mutants reveal a correlation between chromosome conformation and the mode of double-strand break repair during Caenorhabditis elegans meiosis. Genetics. 2007 Aug; 176(4):2027-33. PMID: 17565963.
    Citations: 34     Fields:    Translation:AnimalsCells
  42. Smolikov S, Eizinger A, Schild-Prufert K, Hurlburt A, McDonald K, Engebrecht J, Villeneuve AM, Colaiácovo MP. SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans. Genetics. 2007 Aug; 176(4):2015-25. PMID: 17565948.
    Citations: 40     Fields:    Translation:AnimalsCells
  43. de Carvalho CE, Colaiácovo MP. SUMO-mediated regulation of synaptonemal complex formation during meiosis. Genes Dev. 2006 Aug 01; 20(15):1986-92. PMID: 16882975.
    Citations: 17     Fields:    Translation:AnimalsCells
  44. Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M, Shi Y. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 2006 May 05; 125(3):467-81. PMID: 16603238.
    Citations: 332     Fields:    Translation:HumansAnimalsCells
  45. Colaiácovo MP. The many facets of SC function during C. elegans meiosis. Chromosoma. 2006 Jun; 115(3):195-211. PMID: 16555015.
    Citations: 31     Fields:    Translation:AnimalsCells
  46. Nabeshima K, Villeneuve AM, Colaiácovo MP. Crossing over is coupled to late meiotic prophase bivalent differentiation through asymmetric disassembly of the SC. J Cell Biol. 2005 Feb 28; 168(5):683-9. PMID: 15738262.
    Citations: 59     Fields:    Translation:AnimalsCells
  47. Colaiácovo MP, MacQueen AJ, Martinez-Perez E, McDonald K, Adamo A, La Volpe A, Villeneuve AM. Synaptonemal complex assembly in C. elegans is dispensable for loading strand-exchange proteins but critical for proper completion of recombination. Dev Cell. 2003 Sep; 5(3):463-74. PMID: 12967565.
    Citations: 157     Fields:    Translation:AnimalsCells
  48. MacQueen AJ, Colaiácovo MP, McDonald K, Villeneuve AM. Synapsis-dependent and -independent mechanisms stabilize homolog pairing during meiotic prophase in C. elegans. Genes Dev. 2002 Sep 15; 16(18):2428-42. PMID: 12231631.
    Citations: 155     Fields:    Translation:AnimalsCells
  49. Colaiácovo MP, Stanfield GM, Reddy KC, Reinke V, Kim SK, Villeneuve AM. A targeted RNAi screen for genes involved in chromosome morphogenesis and nuclear organization in the Caenorhabditis elegans germline. Genetics. 2002 Sep; 162(1):113-28. PMID: 12242227.
    Citations: 31     Fields:    Translation:AnimalsCells
  50. Dernburg AF, Zalevsky J, Colaiácovo MP, Villeneuve AM. Transgene-mediated cosuppression in the C. elegans germ line. Genes Dev. 2000 Jul 01; 14(13):1578-83. PMID: 10887151.
    Citations: 51     Fields:    Translation:AnimalsCells
  51. Colaiácovo MP, Pâques F, Haber JE. Removal of one nonhomologous DNA end during gene conversion by a RAD1- and MSH2-independent pathway. Genetics. 1999 Apr; 151(4):1409-23. PMID: 10101166.
    Citations: 40     Fields:    Translation:AnimalsCells
  52. Sugawara N, Pâques F, Colaiácovo M, Haber JE. Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9214-9. PMID: 9256462.
    Citations: 136     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.