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profileMariella Gruber Filbin, M.D.,Ph.D.

TitleInstructor in Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildren's Hospital
Housestaff Lounge Pavillion Lobby
300 Longwood Ave
Boston MA 02115
Phone617/355-6369
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Venteicher AS, Tirosh I, Hebert C, Yizhak K, Neftel C, Filbin MG, Hovestadt V, Escalante LE, Shaw ML, Rodman C, Gillespie SM, Dionne D, Luo CC, Ravichandran H, Mylvaganam R, Mount C, Onozato ML, Nahed BV, Wakimoto H, Curry WT, Iafrate AJ, Rivera MN, Frosch MP, Golub TR, Brastianos PK, Getz G, Patel AP, Monje M, Cahill DP, Rozenblatt-Rosen O, Louis DN, Bernstein BE, Regev A, Suvà ML. Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science. 2017 Mar 31; 355(6332). PMID: 28360267.
    View in: PubMed
  2. Tirosh I, Venteicher AS, Hebert C, Escalante LE, Patel AP, Yizhak K, Fisher JM, Rodman C, Mount C, Filbin MG, Neftel C, Desai N, Nyman J, Izar B, Luo CC, Francis JM, Patel AA, Onozato ML, Riggi N, Livak KJ, Gennert D, Satija R, Nahed BV, Curry WT, Martuza RL, Mylvaganam R, Iafrate AJ, Frosch MP, Golub TR, Rivera MN, Getz G, Rozenblatt-Rosen O, Cahill DP, Monje M, Bernstein BE, Louis DN, Regev A, Suvà ML. Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma. Nature. 2016 11 10; 539(7628):309-313. PMID: 27806376.
    View in: PubMed
  3. Filbin MG, Suvà ML. Gliomas Genomics and Epigenomics: Arriving at the Start and Knowing It for the First Time. Annu Rev Pathol. 2016 May 23; 11:497-521. PMID: 26980161.
    View in: PubMed
  4. Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA. A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. J Vis Exp. 2015 Nov 07; (105):e53304. PMID: 26575352; PMCID: PMC4692695 [Available on 11/07/16].
  5. Filbin MG, Stiles CD. Of Brains and Blood: Developmental Origins of Glioma Diversity? Cancer Cell. 2015 Oct 12; 28(4):403-4. PMID: 26461085.
    View in: PubMed
  6. Filbin MG, Segal RA. How neuronal activity regulates glioma cell proliferation. Neuro Oncol. 2015 Dec; 17(12):1543-4. PMID: 26359210; PMCID: PMC4633934 [Available on 12/01/16].
  7. Siddiq MM, Hannila SS, Carmel JB, Bryson JB, Hou J, Nikulina E, Willis MR, Mellado W, Richman EL, Hilaire M, Hart RP, Filbin MT. Metallothionein-I/II Promotes Axonal Regeneration in the Central Nervous System. J Biol Chem. 2015 Jun 26; 290(26):16343-56. PMID: 25947372; PMCID: PMC4481232 [Available on 06/26/16].
  8. Martinez J, Stessin AM, Campana A, Hou J, Nikulina E, Buck J, Levin LR, Filbin MT. Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors. J Neurosci. 2014 Jul 09; 34(28):9281-9. PMID: 25009261; PMCID: PMC4087207.
  9. Wyatt LA, Filbin MT, Keirstead HS. PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells. J Comp Neurol. 2014 Aug 15; 522(12):2741-55. PMID: 24610700.
    View in: PubMed
  10. Filbin MG, Dabral SK, Pazyra-Murphy MF, Ramkissoon S, Kung AL, Pak E, Chung J, Theisen MA, Sun Y, Franchetti Y, Sun Y, Shulman DS, Redjal N, Tabak B, Beroukhim R, Wang Q, Zhao J, Dorsch M, Buonamici S, Ligon KL, Kelleher JF, Segal RA. Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities. Nat Med. 2013 Nov; 19(11):1518-23. PMID: 24076665; PMCID: PMC3923315.
  11. Hannila SS, Siddiq MM, Carmel JB, Hou J, Chaudhry N, Bradley PM, Hilaire M, Richman EL, Hart RP, Filbin MT. Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-ß signaling protein Smad2. J Neurosci. 2013 Mar 20; 33(12):5138-51. PMID: 23516280; PMCID: PMC3684282.
  12. Costa LM, Pereira JE, Filipe VM, Magalhães LG, Couto PA, Gonzalo-Orden JM, Raimondo S, Geuna S, Maurício AC, Nikulina E, Filbin MT, Varejão AS. Rolipram promotes functional recovery after contusive thoracic spinal cord injury in rats. Behav Brain Res. 2013 Apr 15; 243:66-73. PMID: 23295392.
    View in: PubMed
  13. Perdigoto AL, Chaudhry N, Barnes GN, Filbin MT, Carter BD. A novel role for PTEN in the inhibition of neurite outgrowth by myelin-associated glycoprotein in cortical neurons. Mol Cell Neurosci. 2011 Jan; 46(1):235-44. PMID: 20869442; PMCID: PMC3018674.
  14. Reismüller B, Azizi AA, Peyrl A, Heinrich M, Gruber-Olipitz M, Luckner D, Rothschild KV, Slavc I. Feasibility and tolerability of bevacizumab in children with primary CNS tumors. Pediatr Blood Cancer. 2010 May; 54(5):681-6. PMID: 20066713.
    View in: PubMed
  15. Ma TC, Campana A, Lange PS, Lee HH, Banerjee K, Bryson JB, Mahishi L, Alam S, Giger RJ, Barnes S, Morris SM, Willis DE, Twiss JL, Filbin MT, Ratan RR. A large-scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone daidzeinas a clinically approved small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. J Neurosci. 2010 Jan 13; 30(2):739-48. PMID: 20071539; PMCID: PMC3554247.
  16. Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 2009 Oct 29; 64(2):165-72. PMID: 19874785; PMCID: PMC2773653.
  17. Gruber-Olipitz M, Segal RA. Live or let die: CCM2 provides the link. Neuron. 2009 Sep 10; 63(5):559-60. PMID: 19755097.
    View in: PubMed
  18. Deng K, He H, Qiu J, Lorber B, Bryson JB, Filbin MT. Increased synthesis of spermidine as a result of upregulation of arginase I promotes axonal regeneration in culture and in vivo. J Neurosci. 2009 Jul 29; 29(30):9545-52. PMID: 19641117.
    View in: PubMed
  19. Peyrl A, Azizi A, Czech T, Gruber-Olipitz M, Jones N, Haberler C, Prayer D, Autzinger E, Slavc I. Tumor stabilization under treatment with imatinib in progressive hypothalamic-chiasmatic glioma. Pediatr Blood Cancer. 2009 Apr; 52(4):476-80. PMID: 19061223.
    View in: PubMed
  20. Gruber-Olipitz M, Ströbel T, Kang SU, John JP, Grotzer MA, Slavc I, Lubec G. Neurotrophin 3/TrkC-regulated proteins in the human medulloblastoma cell line DAOY. Electrophoresis. 2009 Feb; 30(3):540-9. PMID: 19156760.
    View in: PubMed
  21. Peyrl A, Sauermann R, Traunmueller F, Azizi AA, Gruber-Olipitz M, Gupper A, Slavc I. Pharmacokinetics and safety of intrathecal liposomal cytarabine in children aged <3 years. Clin Pharmacokinet. 2009; 48(4):265-71. PMID: 19492871.
    View in: PubMed
  22. Filbin MT. PirB, a second receptor for the myelin inhibitors of axonal regeneration Nogo66, MAG, and OMgp: implications for regeneration in vivo. Neuron. 2008 Dec 10; 60(5):740-2. PMID: 19081369.
    View in: PubMed
  23. Azizi AA, Kang SU, Freilinger A, Gruber-Olipitz M, Chen WQ, Yang JW, Hengstschläger M, Slavc I, Lubec G. Mitosis-dependent protein expression in neuroblastoma cell line N1E-115. J Proteome Res. 2008 Aug; 7(8):3412-22. PMID: 18582092.
    View in: PubMed
  24. Gruber-Olipitz M, Ströbel T, Chen WQ, Grotzer MA, Quehenberger F, Slavc I, Lubec G. Synthesis, chaperoning, and metabolism of proteins are regulated by NT-3/TrkC signaling in the medulloblastoma cell line DAOY. J Proteome Res. 2008 May; 7(5):1932-44. PMID: 18336001.
    View in: PubMed
  25. Spencer TK, Mellado W, Filbin MT. BDNF activates CaMKIV and PKA in parallel to block MAG-mediated inhibition of neurite outgrowth. Mol Cell Neurosci. 2008 May; 38(1):110-6. PMID: 18381242; PMCID: PMC2692908.
  26. Hannila SS, Filbin MT. The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury. Exp Neurol. 2008 Feb; 209(2):321-32. PMID: 17720160; PMCID: PMC2692909.
  27. Cao Z, Qiu J, Domeniconi M, Hou J, Bryson JB, Mellado W, Filbin MT. The inhibition site on myelin-associated glycoprotein is within Ig-domain 5 and is distinct from the sialic acid binding site. J Neurosci. 2007 Aug 22; 27(34):9146-54. PMID: 17715351.
    View in: PubMed
  28. Hannila SS, Siddiq MM, Filbin MT. Therapeutic approaches to promoting axonal regeneration in the adult mammalian spinal cord. Int Rev Neurobiol. 2007; 77:57-105. PMID: 17178472.
    View in: PubMed
  29. Chaudhry N, Filbin MT. Myelin-associated inhibitory signaling and strategies to overcome inhibition. J Cereb Blood Flow Metab. 2007 Jun; 27(6):1096-107. PMID: 17033690.
    View in: PubMed
  30. Filbin MT. Recapitulate development to promote axonal regeneration: good or bad approach? Philos Trans R Soc Lond B Biol Sci. 2006 Sep 29; 361(1473):1565-74. PMID: 16939975; PMCID: PMC1664663.
  31. Filbin MT. How inflammation promotes regeneration. Nat Neurosci. 2006 Jun; 9(6):715-7. PMID: 16732197.
    View in: PubMed
  32. Gruber-Olipitz M, Yang JW, Slavc I, Lubec G. Nectin-like molecule 1 is a high abundance protein in cerebellar neurons. Amino Acids. 2006 Jun; 30(4):409-15. PMID: 16773244.
    View in: PubMed
  33. Cao Z, Gao Y, Bryson JB, Hou J, Chaudhry N, Siddiq M, Martinez J, Spencer T, Carmel J, Hart RB, Filbin MT. The cytokine interleukin-6 is sufficient but not necessary to mimic the peripheral conditioning lesion effect on axonal growth. J Neurosci. 2006 May 17; 26(20):5565-73. PMID: 16707807.
    View in: PubMed
  34. Gruber-Olipitz M, Yang JW, Stroebel T, Slavc I, Lubec G. The medulloblastoma cell line DAOY but not eleven other tumor cell lines expresses minichromosome maintenance protein 4. Cancer Lett. 2006 Jul 08; 238(1):76-84. PMID: 16051427.
    View in: PubMed
  35. Domeniconi M, Zampieri N, Spencer T, Hilaire M, Mellado W, Chao MV, Filbin MT. MAG induces regulated intramembrane proteolysis of the p75 neurotrophin receptor to inhibit neurite outgrowth. Neuron. 2005 Jun 16; 46(6):849-55. PMID: 15953414.
    View in: PubMed
  36. Domeniconi M, Filbin MT. Overcoming inhibitors in myelin to promote axonal regeneration. J Neurol Sci. 2005 Jun 15; 233(1-2):43-7. PMID: 15949495.
    View in: PubMed
  37. Gao Y, Deng K, Hou J, Bryson JB, Barco A, Nikulina E, Spencer T, Mellado W, Kandel ER, Filbin MT. Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo. Neuron. 2004 Nov 18; 44(4):609-21. PMID: 15541310.
    View in: PubMed
  38. Afjehi-Sadat L, Gruber-Olipitz M, Felizardo M, Slavc I, Lubec G. Expression of proteasomal proteins in ten different tumor cell lines. Amino Acids. 2004 Oct; 27(2):129-40. PMID: 15455211.
    View in: PubMed
  39. Lu P, Yang H, Jones LL, Filbin MT, Tuszynski MH. Combinatorial therapy with neurotrophins and cAMP promotes axonal regeneration beyond sites of spinal cord injury. J Neurosci. 2004 Jul 14; 24(28):6402-9. PMID: 15254096.
    View in: PubMed
  40. Nikulina E, Tidwell JL, Dai HN, Bregman BS, Filbin MT. The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8786-90. PMID: 15173585; PMCID: PMC423273.
  41. Pearse DD, Pereira FC, Marcillo AE, Bates ML, Berrocal YA, Filbin MT, Bunge MB. cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury. Nat Med. 2004 Jun; 10(6):610-6. PMID: 15156204.
    View in: PubMed
  42. Spencer T, Filbin MT. A role for cAMP in regeneration of the adult mammalian CNS. J Anat. 2004 Jan; 204(1):49-55. PMID: 14690477; PMCID: PMC1571233.
  43. Gao Y, Nikulina E, Mellado W, Filbin MT. Neurotrophins elevate cAMP to reach a threshold required to overcome inhibition by MAG through extracellular signal-regulated kinase-dependent inhibition of phosphodiesterase. J Neurosci. 2003 Dec 17; 23(37):11770-7. PMID: 14684879.
    View in: PubMed
  44. Filbin MT. Myelin-associated inhibitors of axonal regeneration in the adult mammalian CNS. Nat Rev Neurosci. 2003 Sep; 4(9):703-13. PMID: 12951563.
    View in: PubMed
  45. Spencer T, Domeniconi M, Cao Z, Filbin MT. New roles for old proteins in adult CNS axonal regeneration. Curr Opin Neurobiol. 2003 Feb; 13(1):133-9. PMID: 12593992.
    View in: PubMed
  46. Cai D, Deng K, Mellado W, Lee J, Ratan RR, Filbin MT. Arginase I and polyamines act downstream from cyclic AMP in overcoming inhibition of axonal growth MAG and myelin in vitro. Neuron. 2002 Aug 15; 35(4):711-9. PMID: 12194870.
    View in: PubMed
  47. Domeniconi M, Cao Z, Spencer T, Sivasankaran R, Wang K, Nikulina E, Kimura N, Cai H, Deng K, Gao Y, He Z, Filbin M. Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth. Neuron. 2002 Jul 18; 35(2):283-90. PMID: 12160746.
    View in: PubMed
  48. Qiu J, Cai D, Dai H, McAtee M, Hoffman PN, Bregman BS, Filbin MT. Spinal axon regeneration induced by elevation of cyclic AMP. Neuron. 2002 Jun 13; 34(6):895-903. PMID: 12086638.
    View in: PubMed
  49. Qiu J, Cai D, Filbin MT. A role for cAMP in regeneration during development and after injury. Prog Brain Res. 2002; 137:381-7. PMID: 12440380.
    View in: PubMed
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