Harvard Catalyst Profiles

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Li Zhou, Ph.D., M.D.

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Best Paper Selection for the Yearbook of Medical Informatics
Distinguished Paper Award, Medinfo / World Congress on Medical and Health Informatics
Care Coordination for Improved Outcomes Challenge, Health 2.0 Developer Challenge
Best Paper Award Nomination, Medinfo / World Congress on Medical and Health Informatics
Partners in Excellence - Leadership and Innovation
Innovation Discovery Award
Partners in Excellence - Quality Treatment and Service
Elected Fellow, American College of Medical Informatics
Faculty Pillar Award - Research Innovation

Available: 01/17/20, Expires: 01/28/22

Severe cutaneous adverse reactions (SCARs) result in substantial morbidity, long term disability, health care burden and a mortality of 10-50%. To advance the science of clinical and genetic risk factor identification for antibiotic SCAR, we will leverage large electronic health record (EHR) data and advanced informatics technology. Through case validation we will create an informatics roadmap for other institutions with similar EHR data to identify SCAR cases and we will establish a data sharing platform, including an online electronic phenotype and patient registry, that can be used to enlarge SCAR cohorts for future large-scale genomics studies.

The student will assist with research activities that include chart review, case identification, data analysis and manuscript presentation.

Available: 02/03/20, Expires: 01/01/21

Health care today is increasingly delivered in the outpatient setting supported by the use of electronic health records (EHRs) with clinical decision support. However, despite the growth in EHR adoption, results are mixed about the impact of these changes on the safety of patient care, including medication safety. Approaches to identifying adverse drug events (ADEs) have improved, but there is no standard approach that is used across multiple organizations to track harm in the aggregate, leaving organizations struggling to know how they are doing with respect to safety. EHRs and computational methods for analyzing EHRs (e.g., natural language processing [NLP]) can be used to both decrease the burden of measuring safety issues and improve reliability of identifying adverse events. The overall goal of this project is to evaluate the performance of artificial intelligence methods in detecting ADEs in ambulatory primary care clinical notes. The student will be involved in diverse research activities, including chart review, method development and implementation, data analysis and manuscript writing.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI150295 (ZHOU, LI) Sep 16, 2019 - Aug 31, 2023
    Clinical Informatics to Advance Epidemiology and Pharmacogenetics of Serious Cutaneous Adverse Drug Reactions
    Role: Principal Investigator
  2. (Li Zhou) Jul 1, 2018 - Jun 30, 2020
    Similar-cAses Finder for Risk Reduction – the SAFRR system
    Role: PI
  3. (Li Zhou) Jul 1, 2018 - Jun 30, 2019
    Computerized Support for Malpractice Auditing and Coding
    Role: PI
  4. R01HS025375 (Li Zhou) May 7, 2018 - Apr 30, 2022
    Improving Allergy Documentation and Clinical Decision Support in the EHR
    Role: PI
  5. (Joshua Lakin) Oct 1, 2017 - Sep 30, 2018
    Brigham Care Redesign Incubator and Startup Program (BCRISP)
    Finding Needles in the Haystack: Using Clinical Data and Machine Learning to Identify Patients for Early Palliative Care Communication Interventions in Inpatient
    Role: Co-investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Blumenthal KG, Acker WW, Li Y, Holtzman NS, Zhou L. Allergy entry and deletion in the electronic health record. Ann Allergy Asthma Immunol. 2017 03; 118(3):380-381. PMID: 28126435.
    Citations: 2     Fields:    Translation:Humans
  2. Blumenthal KG, Lai KH, Huang M, Wallace ZS, Wickner PG, Zhou L. Adverse and Hypersensitivity Reactions to Prescription Nonsteroidal Anti-Inflammatory Agents in a Large Health Care System. J Allergy Clin Immunol Pract. 2017 May - Jun; 5(3):737-743.e3. PMID: 28110055.
    Citations: 10     Fields:    Translation:Humans
  3. Topaz M, Goss F, Blumenthal K, Lai K, Seger DL, Slight SP, Wickner PG, Robinson GA, Fung KW, McClure RC, Spiro S, Acker WW, Bates DW, Zhou L. Towards improved drug allergy alerts: Multidisciplinary expert recommendations. Int J Med Inform. 2017 01; 97:353-355. PMID: 27729200.
    Citations: 3     Fields:    
  4. Topaz M, Radhakrishnan K, Blackley S, Lei V, Lai K, Zhou L. Studying Associations Between Heart Failure Self-Management and Rehospitalizations Using Natural Language Processing. West J Nurs Res. 2017 Jan; 39(1):147-165. PMID: 27628125.
    Citations: 3     Fields:    
  5. Topaz M, Lai K, Dowding D, Lei VJ, Zisberg A, Bowles KH, Zhou L. Automated identification of wound information in clinical notes of patients with heart diseases: Developing and validating a natural language processing application. Int J Nurs Stud. 2016 Dec; 64:25-31. PMID: 27668855.
    Citations: 3     Fields:    Translation:Humans
  6. Goss FR, Zhou L, Weiner SG. Incidence of speech recognition errors in the emergency department. Int J Med Inform. 2016 09; 93:70-3. PMID: 27435949.
    Citations: 3     Fields:    Translation:Humans
  7. Zhou L, Dhopeshwarkar N, Blumenthal KG, Goss F, Topaz M, Slight SP, Bates DW. Drug allergies documented in electronic health records of a large healthcare system. Allergy. 2016 09; 71(9):1305-13. PMID: 26970431.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
  8. Topaz M, Lai K, Dhopeshwarkar N, Seger DL, Sa'adon R, Goss F, Rozenblum R, Zhou L. Clinicians' Reports in Electronic Health Records Versus Patients' Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and Atorvastatin. Drug Saf. 2016 Mar; 39(3):241-50. PMID: 26715498.
    Citations: 7     Fields:    Translation:Humans
  9. Topaz M, Radhakrishnan K, Lei V, Zhou L. Mining Clinicians' Electronic Documentation to Identify Heart Failure Patients with Ineffective Self-Management: A Pilot Text-Mining Study. Stud Health Technol Inform. 2016; 225:856-7. PMID: 27332377.
    Citations: 1     Fields:    Translation:Humans
  10. Topaz M, Seger DL, Slight SP, Goss F, Lai K, Wickner PG, Blumenthal K, Dhopeshwarkar N, Chang F, Bates DW, Zhou L. Rising drug allergy alert overrides in electronic health records: an observational retrospective study of a decade of experience. J Am Med Inform Assoc. 2016 05; 23(3):601-8. PMID: 26578227.
    Citations: 18     Fields:    Translation:Humans
  11. Plasek JM, Goss FR, Lai KH, Lau JJ, Seger DL, Blumenthal KG, Wickner PG, Slight SP, Chang FY, Topaz M, Bates DW, Zhou L. Food entries in a large allergy data repository. J Am Med Inform Assoc. 2016 Apr; 23(e1):e79-87. PMID: 26384406.
    Citations: 6     Fields:    Translation:Humans
  12. Lai KH, Topaz M, Goss FR, Zhou L. Automated misspelling detection and correction in clinical free-text records. J Biomed Inform. 2015 Jun; 55:188-95. PMID: 25917057.
    Citations: 9     Fields:    
  13. Topaz M, Seger DL, Lai K, Wickner PG, Goss F, Dhopeshwarkar N, Chang F, Bates DW, Zhou L. High Override Rate for Opioid Drug-allergy Interaction Alerts: Current Trends and Recommendations for Future. Stud Health Technol Inform. 2015; 216:242-6. PMID: 26262047.
    Citations: 9     Fields:    Translation:Humans
  14. Zhou L, Baughman AW, Lei VJ, Lai KH, Navathe AS, Chang F, Sordo M, Topaz M, Zhong F, Murrali M, Navathe S, Rocha RA. Identifying Patients with Depression Using Free-text Clinical Documents. Stud Health Technol Inform. 2015; 216:629-33. PMID: 26262127.
    Citations: 5     Fields:    Translation:Humans
  15. Blumenthal KG, Wickner PG, Lau JJ, Zhou L. Stevens-Johnson syndrome and toxic epidermal necrolysis: a cross-sectional analysis of patients in an integrated allergy repository of a large health care system. J Allergy Clin Immunol Pract. 2015 Mar-Apr; 3(2):277-280.e1. PMID: 25609329.
    Citations: 9     Fields:    Translation:Humans
  16. Goss FR, Plasek JM, Lau JJ, Seger DL, Chang FY, Zhou L. An evaluation of a natural language processing tool for identifying and encoding allergy information in emergency department clinical notes. AMIA Annu Symp Proc. 2014; 2014:580-8. PMID: 25954363.
    Citations: 4     Fields:    Translation:Humans
  17. Zhou L, Lu Y, Vitale CJ, Mar PL, Chang F, Dhopeshwarkar N, Rocha RA. Representation of information about family relatives as structured data in electronic health records. Appl Clin Inform. 2014; 5(2):349-67. PMID: 25024754.
    Citations: 5     Fields:    Translation:Humans
  18. Shu T, Liu H, Goss FR, Yang W, Zhou L, Bates DW, Liang M. EHR adoption across China's tertiary hospitals: a cross-sectional observational study. Int J Med Inform. 2014 Feb; 83(2):113-21. PMID: 24262068.
    Citations: 12     Fields:    
  19. Zhou L, Maviglia SM, Rocha RA. The ability of a retrospective review of electronic health records to fully capture the frequency of supratherapeutic dosing of acetaminophen--reply. JAMA Intern Med. 2013 Jun 10; 173(11):1036. PMID: 23752971.
    Citations:    Fields:    Translation:Humans
  20. Goss FR, Zhou L, Plasek JM, Broverman C, Robinson G, Middleton B, Rocha RA. Evaluating standard terminologies for encoding allergy information. J Am Med Inform Assoc. 2013 Sep-Oct; 20(5):969-79. PMID: 23396542.
    Citations: 9     Fields:    Translation:Humans
  21. Zhou L, Hongsermeier T, Boxwala A, Lewis J, Kawamoto K, Maviglia S, Gentile D, Teich JM, Rocha R, Bell D, Middleton B. Structured representation for core elements of common clinical decision support interventions to facilitate knowledge sharing. Stud Health Technol Inform. 2013; 192:195-9. PMID: 23920543.
    Citations:    Fields:    
  22. Zhou L, Maviglia SM, Mahoney LM, Chang F, Orav EJ, Plasek J, Boulware LJ, Bates DW, Rocha RA. Supratherapeutic dosing of acetaminophen among hospitalized patients. Arch Intern Med. 2012 Dec 10; 172(22):1721-8. PMID: 23401887.
    Citations: 1     Fields:    Translation:Humans
  23. Zhou L, Karipineni N, Lewis J, Maviglia SM, Fairbanks A, Hongsermeier T, Middleton B, Rocha RA. A study of diverse clinical decision support rule authoring environments and requirements for integration. BMC Med Inform Decis Mak. 2012 Nov 12; 12:128. PMID: 23145874.
    Citations: 5     Fields:    
  24. Zhou L, Mahoney LM, Shakurova A, Goss F, Chang FY, Bates DW, Rocha RA. How many medication orders are entered through free-text in EHRs?--a study on hypoglycemic agents. AMIA Annu Symp Proc. 2012; 2012:1079-88. PMID: 23304384.
    Citations: 9     Fields:    Translation:Humans
  25. Zhou L, Plasek JM, Mahoney LM, Chang FY, DiMaggio D, Rocha RA. Mapping Partners Master Drug Dictionary to RxNorm using an NLP-based approach. J Biomed Inform. 2012 Aug; 45(4):626-33. PMID: 22142948.
    Citations: 8     Fields:    Translation:Humans
  26. Zhou L, Plasek JM, Mahoney LM, Karipineni N, Chang F, Yan X, Chang F, Dimaggio D, Goldman DS, Rocha RA. Using Medical Text Extraction, Reasoning and Mapping System (MTERMS) to process medication information in outpatient clinical notes. AMIA Annu Symp Proc. 2011; 2011:1639-48. PMID: 22195230.
    Citations: 18     Fields:    Translation:Humans
  27. Hripcsak G, Knirsch C, Zhou L, Wilcox A, Melton G. Bias associated with mining electronic health records. J Biomed Discov Collab. 2011 Jun 06; 6:48-52. PMID: 21647858.
    Citations: 36     
  28. Zhou L, Plasek JM, Karipineni N, Mahoney LM, Chang F, Dimaggio D, Rocha, RA. Improving Medication Reconciliation Using Natural Language Processing. The 2011 AHRQ Annual Conference, Bethesda, MD. 2011.
  29. Zhou L, Yan X, Chang YJ, Chang F, Rocha, RA. Improving Completeness and Correctness of Medication Lists Using Temporal Reasoning and Clinical Narratives. The AHRQ 2010 Health IT Grantee and Contractor Meeting. 2010.
  30. Zhou L, Rocha RA, Chang YJ, Mahoney LM, Chang F, Maviglia SM. A Study on Using Temporal Reasoning to Augment Clinical Decision Support for Medication Administration. AMIA Annu Symp Proc. 2010; 1326.
  31. Zhou L, Goldberg H, Pabbathi D, Wright A, Goldman DS, Van Putten C, Barley A, Rocha RA. Terminology modeling for an enterprise laboratory orders catalog. AMIA Annu Symp Proc. 2009 Nov 14; 2009:735-9. PMID: 20351950.
    Citations:    Fields:    
  32. Zhou L, Soran CS, Jenter CA, Volk LA, Orav EJ, Bates DW, Simon SR. The relationship between electronic health record use and quality of care over time. J Am Med Inform Assoc. 2009 Jul-Aug; 16(4):457-64. PMID: 19390094.
    Citations: 55     Fields:    Translation:Humans
  33. Zhou L, Maviglia SM, Goldman DS, Barley A, Lewis J, Hongsermeier T, Rocha RA. A Methodology for the Design, Development, and Maintenance of Enterprise Clinical Decision Support Rules. AMIA Annu Symp Proc. 2009; 1107.
  34. Goldman DS, Barley A, Dubois D, Lewis J, Tsivkin K, Zhou L, Rocha RA. Collaboration Process and Tools for Developing Clinical Content. AMIA Annu Symp Proc. 2009; 858.
  35. Jenter CA, Soran CS, Volk LA, Kaushal R, Zhou L, Bates DW, Simon SR. Imminent Adopters of Electronic Health Records: Do Things Go as Planned? AMIA Annu Symp Proc. 2009; 895.
  36. Hripcsak G, Elhadad N, Chen YH, Zhou L, Morrison FP. Using empiric semantic correlation to interpret temporal assertions in clinical texts. J Am Med Inform Assoc. 2009 Mar-Apr; 16(2):220-7. PMID: 19074297.
    Citations: 10     Fields:    Translation:Humans
  37. Zhou L, Gurjar R, Regier R, Morgan S, Meyer T, Aroy T, Goldman DS, Hongsermeier T, Middleton B. A study on design and development of enterprise-wide concepts for clinical documentation templates. AMIA Annu Symp Proc. 2008 Nov 06; 1193. PMID: 18998991.
    Citations: 1     Fields:    
  38. Chen ES, Zhou L, Kashyap V, Schaeffer M, Dykes PC, Goldberg HS. Early experiences in evolving an enterprise-wide information model for laboratory and clinical observations. AMIA Annu Symp Proc. 2008 Nov 06; 106-10. PMID: 18999078.
    Citations: 4     Fields:    
  39. Zhou L, Xu H. Biomedical Scientific Textual Data Types and Processing. In: Liu L, Tamer M, editors, Encyclopedia of Database Systems, Springer. 2008.
  40. Zhou L, Parsons S, Hripcsak G. The evaluation of a temporal reasoning system in processing clinical discharge summaries. J Am Med Inform Assoc. 2008 Jan-Feb; 15(1):99-106. PMID: 17947618.
    Citations: 22     Fields:    Translation:Humans
  41. Zhou L, Hripcsak G. Temporal reasoning with medical data--a review with emphasis on medical natural language processing. J Biomed Inform. 2007 Apr; 40(2):183-202. PMID: 17317332.
    Citations: 33     Fields:    
  42. Zhou L. Representing, Extracting and Reasoning with Temporal Information in Electronic Clinical Narrative Reports. 2007.
  43. Zhou L, Tao Y, Cimino JJ, Chen ES, Liu H, Lussier YA, Hripcsak G, Friedman C. Terminology model discovery using natural language processing and visualization techniques. J Biomed Inform. 2006 Dec; 39(6):626-36. PMID: 16360342.
    Citations: 2     Fields:    Translation:Humans
  44. Hripcsak G, Knirsch C, Zhou L, Wilcox A, Melton GB. Using discordance to improve classification in narrative clinical databases: an application to community-acquired pneumonia. Comput Biol Med. 2007 Mar; 37(3):296-304. PMID: 16620802.
    Citations: 8     Fields:    Translation:Humans
  45. Zhou L, Parsons S, Hripcsak G. Handling implicit and uncertain temporal information in medical text. AMIA Annu Symp Proc. 2006; 1158. PMID: 17238777.
    Citations: 3     Fields:    
  46. Zhou L, Melton GB, Parsons S, Hripcsak G. A temporal constraint structure for extracting temporal information from clinical narrative. J Biomed Inform. 2006 Aug; 39(4):424-39. PMID: 16169282.
    Citations: 31     Fields:    
  47. Zhou L, Friedman C, Parsons S, Hripcsak G. System architecture for temporal information extraction, representation and reasoning in clinical narrative reports. AMIA Annu Symp Proc. 2005; 869-73. PMID: 16779164.
    Citations: 16     Fields:    Translation:Humans
  48. Hripcsak G, Zhou L, Parsons S, Das AK, Johnson SB. Modeling electronic discharge summaries as a simple temporal constraint satisfaction problem. J Am Med Inform Assoc. 2005 Jan-Feb; 12(1):55-63. PMID: 15492038.
    Citations: 14     Fields:    Translation:Humans
  49. Zhou L, Hripcsak G, Parsons S, Das AK, Johnson SB. Reasoning about Time in Electronic Discharge Summaries Using Temporal Constraint Satisfaction Techniques. Workshop in Intelligent Data Analysis in Medicine and Pharmacology (IDMAP). 2004; 73-75.
  50. Qian X, Smith H, Zhou L, Liang J, Garner P. Evidence-based obstetrics in four hospitals in China: An observational study to explore clinical practice, women's preferences and provider's views. BMC Pregnancy Childbirth. 2001; 1(1):1. PMID: 11375051.
    Citations: 22     Fields:    
  51. Song J, Cui C, Zhou L. The Effect of Health Education on Children Psychology. Journal of Chinese Maternal and Child Health. 1999; 12(14).
  52. Zhou L. Genetic and Epidemic Mechanisms of Systemic Lupus. 1996.
  53. Zhou L, Qian X, Liang J. . Acceptability of Current Obstetric Service and Feasibility of a Transformation. Journal of Chinese Maternal and Child Health. 2000; 15 (5).
  54. Liang J, Qian X, Zhou L, Wang ZL, Bi L, Ma J. . A Study on Current Obstetric Services in Multiple Hospitals. Journal of Chinese Maternal and Child Health 2000; 15(7): 233-236.
  55. Qian X, Zhou L, Liang J. Evaluating the Education for Medical Students Specified in Maternal and Child Health. Journal of Chinese Maternal and Child Health. 1999; 14 (6).
  56. Qian X, Zhou L, Liang J. Current Status and Requirements for Obstetric Services. Journal of Chinese Maternal and Child Health 2000; 15 (4).
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.