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Last Name

profileLi Zhou, M.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
AddressPartners Healthcare Systems
Suite 201
93 Worcester St
Wellesley Hills MA 02481
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Collapse Biography 
Collapse awards and honors
1992 - 1996RenMin Scholarship
1998 - 1999Faculty Lecture Competition Award (Third-place)
2005Best Student Paper Finalist
2008Best Paper Selection for the Yearbook of Medical Informatics
2009Distinguish Poster Nomination
2013Distinguished Paper Award, Medinfo / World Congress on Medical and Health Informatics
2015Care Coordination for Improved Outcomes Challenge, Health 2.0 Developer Challenge
2015Best Paper Award Nomination, Medinfo / World Congress on Medical and Health Informatics
2016Partners in Excellence - Leadership and Innovation
2016Innovation Discovery Award

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21 HS024541     (Goss, Foster)Sep 1, 2016 - Aug 31, 2018
Exploratory and Developmental Grant to Improve Health Care Quality through Health Information Technology
Role: Co-Investigator

     (Zhou, Li)Jul 1, 2016 - Jun 30, 2017
Automated Knowledge Extraction from Free-text Malpractice Claims Data to Enhance Coding and Analytics
Role: Principal Investigator

R01HS024264     (ZHOU, LI)Sep 30, 2015 - Sep 29, 2018
NLP to Improve Accuracy and Quality of Dictated Medical Documents
Role: Principal Investigator

R01HS022728     (ZHOU, LI)Sep 30, 2013 - Sep 29, 2017
Encoding and Processing Patient Allergy Information in EHRs
Role: Principal Investigator

R21HS021544     (ZHOU, LI)Jul 1, 2012 - Jun 30, 2014
Integration of an NLP-based application to support medication management
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Blumenthal KG, Acker WW, Li Y, Holtzman NS, Zhou L. Allergy entry and deletion in the electronic health record. Ann Allergy Asthma Immunol. 2017 03; 118(3):380-381. PMID: 28126435.
    View in: PubMed
  2. Blumenthal KG, Lai KH, Huang M, Wallace ZS, Wickner PG, Zhou L. Adverse and Hypersensitivity Reactions to Prescription Nonsteroidal Anti-Inflammatory Agents in a Large Health Care System. J Allergy Clin Immunol Pract. 2017 May - Jun; 5(3):737-743.e3. PMID: 28110055.
    View in: PubMed
  3. Topaz M, Goss F, Blumenthal K, Lai K, Seger DL, Slight SP, Wickner PG, Robinson GA, Fung KW, McClure RC, Spiro S, Acker WW, Bates DW, Zhou L. Towards improved drug allergy alerts: Multidisciplinary expert recommendations. Int J Med Inform. 2017 01; 97:353-355. PMID: 27729200.
    View in: PubMed
  4. Topaz M, Lai K, Dowding D, Lei VJ, Zisberg A, Bowles KH, Zhou L. Automated identification of wound information in clinical notes of patients with heart diseases: Developing and validating a natural language processing application. Int J Nurs Stud. 2016 Dec; 64:25-31. PMID: 27668855.
    View in: PubMed
  5. Topaz M, Radhakrishnan K, Blackley S, Lei V, Lai K, Zhou L. Studying Associations Between Heart Failure Self-Management and Rehospitalizations Using Natural Language Processing. West J Nurs Res. 2016 Sep 14. PMID: 27628125.
    View in: PubMed
  6. Goss FR, Zhou L, Weiner SG. Incidence of speech recognition errors in the emergency department. Int J Med Inform. 2016 09; 93:70-3. PMID: 27435949.
    View in: PubMed
  7. Zhou L, Dhopeshwarkar N, Blumenthal KG, Goss F, Topaz M, Slight SP, Bates DW. Drug allergies documented in electronic health records of a large healthcare system. Allergy. 2016 Sep; 71(9):1305-13. PMID: 26970431.
    View in: PubMed
  8. Topaz M, Lai K, Dhopeshwarkar N, Seger DL, Sa'adon R, Goss F, Rozenblum R, Zhou L. Clinicians' Reports in Electronic Health Records Versus Patients' Concerns in Social Media: A Pilot Study of Adverse Drug Reactions of Aspirin and Atorvastatin. Drug Saf. 2016 Mar; 39(3):241-50. PMID: 26715498.
    View in: PubMed
  9. Topaz M, Radhakrishnan K, Lei V, Zhou L. Mining Clinicians' Electronic Documentation to Identify Heart Failure Patients with Ineffective Self-Management: A Pilot Text-Mining Study. Stud Health Technol Inform. 2016; 225:856-7. PMID: 27332377.
    View in: PubMed
  10. Topaz M, Seger DL, Slight SP, Goss F, Lai K, Wickner PG, Blumenthal K, Dhopeshwarkar N, Chang F, Bates DW, Zhou L. Rising drug allergy alert overrides in electronic health records: an observational retrospective study of a decade of experience. J Am Med Inform Assoc. 2016 May; 23(3):601-8. PMID: 26578227.
    View in: PubMed
  11. Plasek JM, Goss FR, Lai KH, Lau JJ, Seger DL, Blumenthal KG, Wickner PG, Slight SP, Chang FY, Topaz M, Bates DW, Zhou L. Food entries in a large allergy data repository. J Am Med Inform Assoc. 2016 Apr; 23(e1):e79-87. PMID: 26384406; PMCID: PMC4954633 [Available on 04/01/17].
  12. Lai KH, Topaz M, Goss FR, Zhou L. Automated misspelling detection and correction in clinical free-text records. J Biomed Inform. 2015 Jun; 55:188-95. PMID: 25917057.
    View in: PubMed
  13. Topaz M, Seger DL, Lai K, Wickner PG, Goss F, Dhopeshwarkar N, Chang F, Bates DW, Zhou L. High Override Rate for Opioid Drug-allergy Interaction Alerts: Current Trends and Recommendations for Future. Stud Health Technol Inform. 2015; 216:242-6. PMID: 26262047.
    View in: PubMed
  14. Zhou L, Baughman AW, Lei VJ, Lai KH, Navathe AS, Chang F, Sordo M, Topaz M, Zhong F, Murrali M, Navathe S, Rocha RA. Identifying Patients with Depression Using Free-text Clinical Documents. Stud Health Technol Inform. 2015; 216:629-33. PMID: 26262127.
    View in: PubMed
  15. Blumenthal KG, Wickner PG, Lau JJ, Zhou L. Stevens-Johnson syndrome and toxic epidermal necrolysis: a cross-sectional analysis of patients in an integrated allergy repository of a large health care system. J Allergy Clin Immunol Pract. 2015 Mar-Apr; 3(2):277-280.e1. PMID: 25609329; PMCID: PMC4419807.
  16. Goss FR, Plasek JM, Lau JJ, Seger DL, Chang FY, Zhou L. An evaluation of a natural language processing tool for identifying and encoding allergy information in emergency department clinical notes. AMIA Annu Symp Proc. 2014; 2014:580-8. PMID: 25954363; PMCID: PMC4419999.
  17. Zhou L, Lu Y, Vitale CJ, Mar PL, Chang F, Dhopeshwarkar N, Rocha RA. Representation of information about family relatives as structured data in electronic health records. Appl Clin Inform. 2014; 5(2):349-67. PMID: 25024754; PMCID: PMC4081741.
  18. Shu T, Liu H, Goss FR, Yang W, Zhou L, Bates DW, Liang M. EHR adoption across China's tertiary hospitals: a cross-sectional observational study. Int J Med Inform. 2014 Feb; 83(2):113-21. PMID: 24262068.
    View in: PubMed
  19. Zhou L, Maviglia SM, Rocha RA. The ability of a retrospective review of electronic health records to fully capture the frequency of supratherapeutic dosing of acetaminophen--reply. JAMA Intern Med. 2013 Jun 10; 173(11):1036. PMID: 23752971.
    View in: PubMed
  20. Goss FR, Zhou L, Plasek JM, Broverman C, Robinson G, Middleton B, Rocha RA. Evaluating standard terminologies for encoding allergy information. J Am Med Inform Assoc. 2013 Sep-Oct; 20(5):969-79. PMID: 23396542; PMCID: PMC3756252.
  21. Zhou L, Hongsermeier T, Boxwala A, Lewis J, Kawamoto K, Maviglia S, Gentile D, Teich JM, Rocha R, Bell D, Middleton B. Structured representation for core elements of common clinical decision support interventions to facilitate knowledge sharing. Stud Health Technol Inform. 2013; 192:195-9. PMID: 23920543.
    View in: PubMed
  22. Zhou L, Maviglia SM, Mahoney LM, Chang F, Orav EJ, Plasek J, Boulware LJ, Bates DW, Rocha RA. Supratherapeutic dosing of acetaminophen among hospitalized patients. Arch Intern Med. 2012 Dec 10; 172(22):1721-8. PMID: 23401887.
    View in: PubMed
  23. Zhou L, Karipineni N, Lewis J, Maviglia SM, Fairbanks A, Hongsermeier T, Middleton B, Rocha RA. A study of diverse clinical decision support rule authoring environments and requirements for integration. BMC Med Inform Decis Mak. 2012 Nov 12; 12:128. PMID: 23145874; PMCID: PMC3554596.
  24. Zhou L, Mahoney LM, Shakurova A, Goss F, Chang FY, Bates DW, Rocha RA. How many medication orders are entered through free-text in EHRs?--a study on hypoglycemic agents. AMIA Annu Symp Proc. 2012; 2012:1079-88. PMID: 23304384; PMCID: PMC3540584.
  25. Zhou L, Plasek JM, Mahoney LM, Chang FY, DiMaggio D, Rocha RA. Mapping Partners Master Drug Dictionary to RxNorm using an NLP-based approach. J Biomed Inform. 2012 Aug; 45(4):626-33. PMID: 22142948.
    View in: PubMed
  26. Zhou L, Plasek JM, Mahoney LM, Karipineni N, Chang F, Yan X, Chang F, Dimaggio D, Goldman DS, Rocha RA. Using Medical Text Extraction, Reasoning and Mapping System (MTERMS) to process medication information in outpatient clinical notes. AMIA Annu Symp Proc. 2011; 2011:1639-48. PMID: 22195230; PMCID: PMC3243163.
  27. Hripcsak G, Knirsch C, Zhou L, Wilcox A, Melton G. Bias associated with mining electronic health records. J Biomed Discov Collab. 2011 Jun 06; 6:48-52. PMID: 21647858; PMCID: PMC3149555.
  28. Zhou L, Plasek JM, Karipineni N, Mahoney LM, Chang F, Dimaggio D, Rocha, RA. Improving Medication Reconciliation Using Natural Language Processing. The 2011 AHRQ Annual Conference, Bethesda, MD. 2011.
  29. Zhou L, Yan X, Chang YJ, Chang F, Rocha, RA. Improving Completeness and Correctness of Medication Lists Using Temporal Reasoning and Clinical Narratives. The AHRQ 2010 Health IT Grantee and Contractor Meeting. 2010.
  30. Zhou L, Rocha RA, Chang YJ, Mahoney LM, Chang F, Maviglia SM. A Study on Using Temporal Reasoning to Augment Clinical Decision Support for Medication Administration. AMIA Annu Symp Proc. 2010; 1326.
  31. Zhou L, Goldberg H, Pabbathi D, Wright A, Goldman DS, Van Putten C, Barley A, Rocha RA. Terminology modeling for an enterprise laboratory orders catalog. AMIA Annu Symp Proc. 2009 Nov 14; 2009:735-9. PMID: 20351950; PMCID: PMC2815439.
  32. Zhou L, Soran CS, Jenter CA, Volk LA, Orav EJ, Bates DW, Simon SR. The relationship between electronic health record use and quality of care over time. J Am Med Inform Assoc. 2009 Jul-Aug; 16(4):457-64. PMID: 19390094; PMCID: PMC2705247.
  33. Zhou L, Maviglia SM, Goldman DS, Barley A, Lewis J, Hongsermeier T, Rocha RA. A Methodology for the Design, Development, and Maintenance of Enterprise Clinical Decision Support Rules. AMIA Annu Symp Proc. 2009; 1107.
  34. Goldman DS, Barley A, Dubois D, Lewis J, Tsivkin K, Zhou L, Rocha RA. Collaboration Process and Tools for Developing Clinical Content. AMIA Annu Symp Proc. 2009; 858.
  35. Jenter CA, Soran CS, Volk LA, Kaushal R, Zhou L, Bates DW, Simon SR. Imminent Adopters of Electronic Health Records: Do Things Go as Planned? AMIA Annu Symp Proc. 2009; 895.
  36. Hripcsak G, Elhadad N, Chen YH, Zhou L, Morrison FP. Using empiric semantic correlation to interpret temporal assertions in clinical texts. J Am Med Inform Assoc. 2009 Mar-Apr; 16(2):220-7. PMID: 19074297; PMCID: PMC2649319.
  37. Zhou L, Gurjar R, Regier R, Morgan S, Meyer T, Aroy T, Goldman DS, Hongsermeier T, Middleton B. A study on design and development of enterprise-wide concepts for clinical documentation templates. AMIA Annu Symp Proc. 2008 Nov 06; 1193. PMID: 18998991.
    View in: PubMed
  38. Chen ES, Zhou L, Kashyap V, Schaeffer M, Dykes PC, Goldberg HS. Early experiences in evolving an enterprise-wide information model for laboratory and clinical observations. AMIA Annu Symp Proc. 2008 Nov 06; 106-10. PMID: 18999078; PMCID: PMC2656065.
  39. Zhou L, Xu H. Biomedical Scientific Textual Data Types and Processing. In: Liu L, Tamer M, editors, Encyclopedia of Database Systems, Springer. 2008.
  40. Zhou L, Parsons S, Hripcsak G. The evaluation of a temporal reasoning system in processing clinical discharge summaries. J Am Med Inform Assoc. 2008 Jan-Feb; 15(1):99-106. PMID: 17947618; PMCID: PMC2274869.
  41. Zhou L, Hripcsak G. Temporal reasoning with medical data--a review with emphasis on medical natural language processing. J Biomed Inform. 2007 Apr; 40(2):183-202. PMID: 17317332.
    View in: PubMed
  42. Zhou L. Representing, Extracting and Reasoning with Temporal Information in Electronic Clinical Narrative Reports. 2007.
  43. Zhou L, Tao Y, Cimino JJ, Chen ES, Liu H, Lussier YA, Hripcsak G, Friedman C. Terminology model discovery using natural language processing and visualization techniques. J Biomed Inform. 2006 Dec; 39(6):626-36. PMID: 16360342.
    View in: PubMed
  44. Hripcsak G, Knirsch C, Zhou L, Wilcox A, Melton GB. Using discordance to improve classification in narrative clinical databases: an application to community-acquired pneumonia. Comput Biol Med. 2007 Mar; 37(3):296-304. PMID: 16620802.
    View in: PubMed
  45. Zhou L, Parsons S, Hripcsak G. Handling implicit and uncertain temporal information in medical text. AMIA Annu Symp Proc. 2006; 1158. PMID: 17238777; PMCID: PMC1839470.
  46. Zhou L, Melton GB, Parsons S, Hripcsak G. A temporal constraint structure for extracting temporal information from clinical narrative. J Biomed Inform. 2006 Aug; 39(4):424-39. PMID: 16169282.
    View in: PubMed
  47. Zhou L, Friedman C, Parsons S, Hripcsak G. System architecture for temporal information extraction, representation and reasoning in clinical narrative reports. AMIA Annu Symp Proc. 2005; 869-73. PMID: 16779164; PMCID: PMC1560711.
  48. Hripcsak G, Zhou L, Parsons S, Das AK, Johnson SB. Modeling electronic discharge summaries as a simple temporal constraint satisfaction problem. J Am Med Inform Assoc. 2005 Jan-Feb; 12(1):55-63. PMID: 15492038; PMCID: PMC543827.
  49. Zhou L, Hripcsak G, Parsons S, Das AK, Johnson SB. Reasoning about Time in Electronic Discharge Summaries Using Temporal Constraint Satisfaction Techniques. Workshop in Intelligent Data Analysis in Medicine and Pharmacology (IDMAP). 2004; 73-75.
  50. Qian X, Smith H, Zhou L, Liang J, Garner P. Evidence-based obstetrics in four hospitals in China: An observational study to explore clinical practice, women's preferences and provider's views. BMC Pregnancy Childbirth. 2001; 1(1):1. PMID: 11375051.
    View in: PubMed
  51. Song J, Cui C, Zhou L. The Effect of Health Education on Children Psychology. Journal of Chinese Maternal and Child Health. 1999; 12(14).
  52. Zhou L. Genetic and Epidemic Mechanisms of Systemic Lupus. 1996.
  53. Zhou L, Qian X, Liang J. . Acceptability of Current Obstetric Service and Feasibility of a Transformation. Journal of Chinese Maternal and Child Health. 2000; 15 (5).
  54. Liang J, Qian X, Zhou L, Wang ZL, Bi L, Ma J. . A Study on Current Obstetric Services in Multiple Hospitals. Journal of Chinese Maternal and Child Health 2000; 15(7): 233-236.
  55. Qian X, Zhou L, Liang J. Evaluating the Education for Medical Students Specified in Maternal and Child Health. Journal of Chinese Maternal and Child Health. 1999; 14 (6).
  56. Qian X, Zhou L, Liang J. Current Status and Requirements for Obstetric Services. Journal of Chinese Maternal and Child Health 2000; 15 (4).
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