Harvard Catalyst Profiles

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Keiichi Enjyoji, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Flaumenhaft R, Enjyoji K, Schmaier AA. Vasculopathy in COVID-19. Blood. 2022 07 21; 140(3):222-235. PMID: 34986238; PMCID: PMC8736280.
    Citations: 4     Fields:    Translation:HumansCells
  2. Zhang H, Feng L, de Andrade Mello P, Mao C, Near R, Csizmadia E, Chan LL, Enjyoji K, Gao W, Zhao H, Robson SC. Glycoengineered anti-CD39 promotes anticancer responses by depleting suppressive cells and inhibiting angiogenesis in tumor models. J Clin Invest. 2022 07 01; 132(13). PMID: 35775486; PMCID: PMC9246388.
    Citations:    Fields:    Translation:AnimalsCells
  3. Sandhu B, Perez-Matos MC, Tran S, Singhal G, Syed I, Feldbrügge L, Mitsuhashi S, Pelletier J, Huang J, Yalcin Y, Csizmadia E, Tiwari-Heckler S, Enjyoji K, Sévigny J, Maratos-Flier E, Robson SC, Jiang ZG. Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism. Metabolism. 2021 05; 118:154731. PMID: 33631144; PMCID: PMC8052311.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Zhong EH, Ledderose C, De Andrade Mello P, Enjyoji K, Lunderberg JM, Junger W, Robson SC. Structural and functional characterization of engineered bifunctional fusion proteins of CD39 and CD73 ectonucleotidases. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C15-C29. PMID: 33052071; PMCID: PMC7846972.
    Citations: 3     Fields:    Translation:HumansCells
  5. Chaudhry SA, Serrata M, Tomczak L, Higgins S, Ryu J, Laprise D, Enjyoji K, Bekendam R, Kaushik V, Flaumenhaft R, Bendapudi PK. Cationic zinc is required for factor XII recruitment and activation by stimulated platelets and for thrombus formation in vivo. J Thromb Haemost. 2020 09; 18(9):2318-2328. PMID: 32542960.
    Citations: 3     Fields:    Translation:AnimalsCells
  6. Rothweiler S, Feldbrügge L, Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 09; 15(3):375-385. PMID: 31243614.
    Citations: 11     Fields:    Translation:AnimalsCells
  7. Xie A, Robles RJ, Mukherjee S, Zhang H, Feldbrügge L, Csizmadia E, Wu Y, Enjyoji K, Moss AC, Otterbein LE, Quintana FJ, Robson SC, Longhi MS. HIF-1a-induced xenobiotic transporters promote Th17 responses in Crohn's disease. J Autoimmun. 2018 11; 94:122-133. PMID: 30098863; PMCID: PMC6193817.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  8. De Giorgi M, Enjyoji K, Jiang G, Csizmadia E, Mitsuhashi S, Gumina RJ, Smolenski RT, Robson SC. Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice. J Lipid Res. 2017 07; 58(7):1292-1305. PMID: 28487312.
    Citations: 8     Fields:    Translation:AnimalsCells
  9. Todd JN, Poon W, Lyssenko V, Groop L, Nichols B, Wilmot M, Robson S, Enjyoji K, Herman MA, Hu C, Zhang R, Jia W, Ma R, Florez JC, Friedman DJ. Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans. J Clin Endocrinol Metab. 2015 May; 100(5):E688-96. PMID: 25719930; PMCID: PMC4422893.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  10. Gampe K, Stefani J, Hammer K, Brendel P, Pötzsch A, Enikolopov G, Enjyoji K, Acker-Palmer A, Robson SC, Zimmermann H. NTPDase2 and purinergic signaling control progenitor cell proliferation in neurogenic niches of the adult mouse brain. Stem Cells. 2015 Jan; 33(1):253-64. PMID: 25205248.
    Citations: 26     Fields:    Translation:AnimalsCells
  11. Csóka B, Németh ZH, Töro G, Koscsó B, Kókai E, Robson SC, Enjyoji K, Rolandelli RH, Erdélyi K, Pacher P, Haskó G. CD39 improves survival in microbial sepsis by attenuating systemic inflammation. FASEB J. 2015 Jan; 29(1):25-36. PMID: 25318479.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  12. Jiang ZG, Wu Y, Csizmadia E, Feldbrügge L, Enjyoji K, Tigges J, Toxavidis V, Stephan H, Müller CE, Müller CE, McKnight CJ, Moss A, Robson SC. Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma. Purinergic Signal. 2014 Dec; 10(4):611-8. PMID: 25165006.
    Citations: 12     Fields:    Translation:HumansCells
  13. Vandenbeuch A, Anderson CB, Parnes J, Enjyoji K, Robson SC, Finger TE, Kinnamon SC. Role of the ectonucleotidase NTPDase2 in taste bud function. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14789-94. PMID: 23959882.
    Citations: 47     Fields:    Translation:AnimalsCells
  14. Bian S, Sun X, Bai A, Zhang C, Li L, Enjyoji K, Junger WG, Robson SC, Wu Y. P2X7 integrates PI3K/AKT and AMPK-PRAS40-mTOR signaling pathways to mediate tumor cell death. PLoS One. 2013; 8(4):e60184. PMID: 23565201; PMCID: PMC3615040.
    Citations: 60     Fields:    Translation:AnimalsCells
  15. Ekser B, Lin CC, Long C, Echeverri GJ, Hara H, Ezzelarab M, Bogdanov VY, Stolz DB, Enjyoji K, Robson SC, Ayares D, Dorling A, Cooper DK, Gridelli B. Potential factors influencing the development of thrombocytopenia and consumptive coagulopathy after genetically modified pig liver xenotransplantation. Transpl Int. 2012 Aug; 25(8):882-96. PMID: 22642260; PMCID: PMC3394909.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. Zhang Y, Morris KL, Sparrow SK, Dwyer KM, Enjyoji K, Robson SC, Kishore BK. Defective renal water handling in transgenic mice over-expressing human CD39/NTPDase1. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F420-30. PMID: 22622462.
    Citations: 5     Fields:    Translation:HumansAnimals
  17. Sun X, Imai M, Nowak-Machen M, Guckelberger O, Enjyoji K, Wu Y, Khalpey Z, Berberat P, Munasinghe J, Robson SC. Liver damage and systemic inflammatory responses are exacerbated by the genetic deletion of CD39 in total hepatic ischemia. Purinergic Signal. 2011 Dec; 7(4):427-34. PMID: 21656186.
    Citations: 13     Fields:    
  18. Künzli BM, Bernlochner MI, Rath S, Käser S, Csizmadia E, Enjyoji K, Cowan P, d'Apice A, Dwyer K, Rosenberg R, Perren A, Friess H, Maurer CA, Robson SC. Impact of CD39 and purinergic signalling on the growth and metastasis of colorectal cancer. Purinergic Signal. 2011 Jun; 7(2):231-41. PMID: 21484085.
    Citations: 50     Fields:    
  19. Künzli BM, Berberat PO, Dwyer K, Deaglio S, Csizmadia E, Cowan P, d'Apice A, Moore G, Enjyoji K, Friess H, Robson SC. Variable impact of CD39 in experimental murine colitis. Dig Dis Sci. 2011 May; 56(5):1393-403. PMID: 20936356.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  20. Sun X, Wu Y, Gao W, Enjyoji K, Csizmadia E, Müller CE, Murakami T, Robson SC. CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. Gastroenterology. 2010 Sep; 139(3):1030-40. PMID: 20546740; PMCID: PMC2930043.
    Citations: 135     Fields:    Translation:AnimalsCells
  21. Ho KJ, Do NL, Otu HH, Dib MJ, Ren X, Enjyoji K, Robson SC, Terwilliger EF, Karp SJ. Tob1 is a constitutively expressed repressor of liver regeneration. J Exp Med. 2010 Jun 07; 207(6):1197-208. PMID: 20513747.
    Citations: 15     Fields:    Translation:AnimalsCells
  22. Beldi G, Banz Y, Kroemer A, Sun X, Wu Y, Graubardt N, Rellstab A, Nowak M, Enjyoji K, Li X, Junger WG, Candinas D, Robson SC. Deletion of CD39 on natural killer cells attenuates hepatic ischemia/reperfusion injury in mice. Hepatology. 2010 May; 51(5):1702-11. PMID: 20146261.
    Citations: 38     Fields:    Translation:AnimalsCells
  23. Lévesque SA, Kukulski F, Enjyoji K, Robson SC, Sévigny J. NTPDase1 governs P2X7-dependent functions in murine macrophages. Eur J Immunol. 2010 May; 40(5):1473-85. PMID: 20201036; PMCID: PMC3045779.
    Citations: 51     Fields:    Translation:AnimalsCells
  24. Friedman DJ, Künzli BM, A-Rahim YI, Sevigny J, Berberat PO, Enjyoji K, Csizmadia E, Friess H, Robson SC. From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16788-93. PMID: 19805374.
    Citations: 143     Fields:    Translation:HumansAnimals
  25. Vlajkovic SM, Housley GD, Thorne PR, Gupta R, Enjyoji K, Cowan PJ, Charles Liberman M, Robson SC. Preservation of cochlear function in Cd39 deficient mice. Hear Res. 2009 Jul; 253(1-2):77-82. PMID: 19327391.
    Citations: 2     Fields:    Translation:AnimalsCells
  26. Behdad A, Sun X, Khalpey Z, Enjyoji K, Wink M, Wu Y, Usheva A, Robson SC. Vascular smooth muscle cell expression of ectonucleotidase CD39 (ENTPD1) is required for neointimal formation in mice. Purinergic Signal. 2009 Sep; 5(3):335-42. PMID: 19308674.
    Citations: 12     Fields:    
  27. Friedman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, Robson SC. Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease. Diabetes. 2009 Apr; 58(4):999-1006. PMID: 19095759; PMCID: PMC2661602.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  28. Beldi G, Wu Y, Banz Y, Nowak M, Miller L, Enjyoji K, Haschemi A, Yegutkin GG, Candinas D, Exley M, Robson SC. Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis. Hepatology. 2008 Sep; 48(3):841-52. PMID: 18752325.
    Citations: 55     Fields:    Translation:AnimalsCells
  29. Beldi G, Wu Y, Sun X, Imai M, Enjyoji K, Csizmadia E, Candinas D, Erb L, Robson SC. Regulated catalysis of extracellular nucleotides by vascular CD39/ENTPD1 is required for liver regeneration. Gastroenterology. 2008 Nov; 135(5):1751-60. PMID: 18804472; PMCID: PMC2900919.
    Citations: 42     Fields:    Translation:AnimalsCells
  30. Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes. 2008 Sep; 57(9):2311-20. PMID: 18567823; PMCID: PMC2518482.
    Citations: 52     Fields:    Translation:AnimalsCells
  31. Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann J. Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F965-70. PMID: 18256308.
    Citations: 13     Fields:    Translation:AnimalsCells
  32. Färber K, Markworth S, Pannasch U, Nolte C, Prinz V, Kronenberg G, Gertz K, Endres M, Bechmann I, Enjyoji K, Robson SC, Kettenmann H. The ectonucleotidase cd39/ENTPDase1 modulates purinergic-mediated microglial migration. Glia. 2008 Feb; 56(3):331-41. PMID: 18098126.
    Citations: 45     Fields:    Translation:AnimalsCells
  33. Beldi G, Enjyoji K, Wu Y, Miller L, Banz Y, Sun X, Robson SC. The role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolism. Front Biosci. 2008 Jan 01; 13:2588-603. PMID: 17981736.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  34. Künzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D, Berberat PO, Friess H, Robson SC. Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice. Gastroenterology. 2008 Jan; 134(1):292-305. PMID: 18036594; PMCID: PMC2189558.
    Citations: 22     Fields:    Translation:Animals
  35. Jackson SW, Hoshi T, Wu Y, Sun X, Enjyoji K, Cszimadia E, Sundberg C, Robson SC. Disordered purinergic signaling inhibits pathological angiogenesis in cd39/Entpd1-null mice. Am J Pathol. 2007 Oct; 171(4):1395-404. PMID: 17823293; PMCID: PMC1988887.
    Citations: 48     Fields:    Translation:AnimalsCells
  36. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65. PMID: 17502665; PMCID: PMC2118603.
    Citations: 975     Fields:    Translation:AnimalsCells
  37. Friedman DJ, Rennke HG, Csizmadia E, Enjyoji K, Robson SC. The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy. Diabetes. 2007 Sep; 56(9):2371-9. PMID: 17473221.
    Citations: 25     Fields:    Translation:HumansAnimals
  38. Atkinson B, Dwyer K, Enjyoji K, Robson SC. Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):217-22. PMID: 16476557.
    Citations: 54     Fields:    Translation:HumansAnimals
  39. Robson SC, Wu Y, Sun X, Knosalla C, Dwyer K, Enjyoji K. Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. Semin Thromb Hemost. 2005 Apr; 31(2):217-33. PMID: 15852225.
    Citations: 88     Fields:    Translation:HumansAnimals
  40. Guckelberger O, Sun XF, Sévigny J, Imai M, Kaczmarek E, Enjyoji K, Kruskal JB, Robson SC. Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury. Thromb Haemost. 2004 Mar; 91(3):576-86. PMID: 14983235.
    Citations: 41     Fields:    Translation:AnimalsCells
  41. Eltzschig HK, Ibla JC, Furuta GT, Leonard MO, Jacobson KA, Enjyoji K, Robson SC, Colgan SP. Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med. 2003 Sep 01; 198(5):783-96. PMID: 12939345; PMCID: PMC2194189.
    Citations: 238     Fields:    Translation:HumansCells
  42. HajMohammadi S, Enjyoji K, Princivalle M, Christi P, Lech M, Beeler D, Rayburn H, Schwartz JJ, Barzegar S, de Agostini AI, Post MJ, Rosenberg RD, Shworak NW. Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. J Clin Invest. 2003 Apr; 111(7):989-99. PMID: 12671048; PMCID: PMC152578.
    Citations: 53     Fields:    Translation:AnimalsCells
  43. Mizumoto N, Kumamoto T, Robson SC, Sévigny J, Matsue H, Enjyoji K, Takashima A. CD39 is the dominant Langerhans cell-associated ecto-NTPDase: modulatory roles in inflammation and immune responsiveness. Nat Med. 2002 Apr; 8(4):358-65. PMID: 11927941.
    Citations: 133     Fields:    Translation:AnimalsCells
  44. Goepfert C, Sundberg C, Sévigny J, Enjyoji K, Hoshi T, Csizmadia E, Robson S. Disordered cellular migration and angiogenesis in cd39-null mice. Circulation. 2001 Dec 18; 104(25):3109-15. PMID: 11748109.
    Citations: 61     Fields:    Translation:AnimalsCells
  45. Braun N, Sévigny J, Robson SC, Enjyoji K, Guckelberger O, Hammer K, Di Virgilio F, Zimmermann H. Assignment of ecto-nucleoside triphosphate diphosphohydrolase-1/cd39 expression to microglia and vasculature of the brain. Eur J Neurosci. 2000 Dec; 12(12):4357-66. PMID: 11122346.
    Citations: 58     Fields:    Translation:AnimalsCells
  46. Imai M, Takigami K, Guckelberger O, Lin Y, Sevigny J, Kaczmarek E, Goepfert C, Enjyoji K, Bach FH, Rosenberg RD, Robson SC. CD39/vascular ATP diphosphohydrolase modulates xenograft survival. Transplant Proc. 2000 Aug; 32(5):969. PMID: 10936301.
    Citations: 11     Fields:    Translation:Animals
  47. Imai M, Takigami K, Guckelberger O, Enjyoji K, Smith RN, Lin Y, Csizmadia E, Sévigny J, Rosenberg RD, Bach FH, Robson SC. Modulation of nucleoside [correction of nucleotide] triphosphate diphosphohydrolase-1 (NTPDase-1)cd39 in xenograft rejection. Mol Med. 1999 Nov; 5(11):743-52. PMID: 10656876; PMCID: PMC2230486.
    Citations: 14     Fields:    Translation:Animals
  48. Enjyoji K, Sévigny J, Lin Y, Frenette PS, Christie PD, Esch JS, Imai M, Edelberg JM, Rayburn H, Lech M, Beeler DL, Csizmadia E, Wagner DD, Robson SC, Rosenberg RD. Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med. 1999 Sep; 5(9):1010-7. PMID: 10470077.
    Citations: 188     Fields:    Translation:AnimalsCells
  49. Hine C, Enjyoji Ki, Kokame K, Nakamura S, Takei A, Kamikubo Y, Sueishi K, Kato H. Monkey hepatocytes efficiently express tissue factor pathway inhibitor (TFPI), in contrast with human and rat hepatocytes. J Biochem. 1999 Jun; 125(6):1039-47. PMID: 10348905.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.