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Jeffrey Way, Ph.D.

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Mentoring
Available: 01/01/23, Expires: 12/31/23

In addition to promoting red blood cell formation, erythropoietin protects neurons against hypoxia and other insults. Erythropoietin (EPO) ameliorates neural degeneration in animal models of ALS, multiple sclerosis, traumatic brain injury, and other neural disorders. Unfortunately, EPO also enhances blood clotting, which leads to heart attacks, stroke, and deep vein thrombosis. We are engineering forms of EPO that promote neuroprotection but do not cause thrombosis, have a long plasma half-life, have the potential for delivery by inhalation instead of injection, and for which anti-drug antibodies should not cross-react with endogenous EPO. This work will be carried out in the lab of Prof. Pamela Silver in the HMS Dept. of Systems Biology. The student work will involve protein design, protein expression, and testing in cells and mice.

Available: 01/01/23, Expires: 12/31/23

In addition to promoting red blood cell formation, erythropoietin protects neurons against hypoxia and other insults. Erythropoietin (EPO) ameliorates neural degeneration in animal models of ALS, multiple sclerosis, traumatic brain injury, and other neural disorders. Unfortunately, EPO also enhances blood clotting, which leads to heart attacks, stroke, and deep vein thrombosis. We are engineering forms of EPO that promote neuroprotection but do not cause thrombosis, have a long plasma half-life, have the potential for delivery by inhalation instead of injection, and for which anti-drug antibodies should not cross-react with endogenous EPO. This work will be carried out in the lab of Prof. Pamela Silver in the HMS Dept. of Systems Biology. The work will involve protein design, protein expression, and testing in cells and mice.

Targeted Erythropoietin Fusion Protein for the Treatment of Anemia
Part Time, 01/02/17 - 08/01/19
Fusion Protein Therapeutic for Pancreatitis
Soma Weiss, 07/01/18 - 07/01/19

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.