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Matthew R Spite, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sansbury BE, Li X, Wong B, Patsalos A, Giannakis N, Zhang MJ, Nagy L, Spite M. Myeloid ALX/FPR2 regulates vascularization following tissue injury. Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25):14354-14364. PMID: 32513697.
  2. Sharma M, Schlegel MP, Afonso MS, Brown EJ, Rahman K, Weinstock A, Sansbury BE, Corr EM, van Solingen C, Koelwyn GJ, Shanley LC, Beckett L, Peled D, Lafaille JJ, Spite M, Loke P, Fisher EA, Moore KJ. Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression. Circ Res. 2020 Jul 17; 127(3):335-353. PMID: 32336197.
  3. Rymut N, Heinz J, Sadhu S, Hosseini Z, Riley CO, Marinello M, Maloney J, MacNamara KC, Spite M, Fredman G. Resolvin D1 promotes efferocytosis in aging by limiting senescent cell-induced MerTK cleavage. FASEB J. 2020 01; 34(1):597-609. PMID: 31914705.
  4. Helsley RN, Varadharajan V, Brown AL, Gromovsky AD, Schugar RC, Ramachandiran I, Fung K, Kabbany MN, Banerjee R, Neumann CK, Finney C, Pathak P, Orabi D, Osborn LJ, Massey W, Zhang R, Kadam A, Sansbury BE, Pan C, Sacks J, Lee RG, Crooke RM, Graham MJ, Lemieux ME, Gogonea V, Kirwan JP, Allende DS, Civelek M, Fox PL, Rudel LL, Lusis AJ, Spite M, Brown JM. Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease. Elife. 2019 10 17; 8. PMID: 31621579.
  5. Sharma M, Schlegel M, Brown EJ, Sansbury BE, Weinstock A, Afonso MS, Corr EM, van Solingen C, Shanley LC, Peled D, Ramasamy R, Schmidt AM, Spite M, Fisher EA, Moore KJ. Netrin-1 Alters Adipose Tissue Macrophage Fate and Function in Obesity. Immunometabolism. 2019; 1(2). PMID: 31428465.
  6. Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, van Leyen K, Goodyear LJ, Blüher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. 12-Lipoxygenase Regulates Cold Adaptation and Glucose Metabolism by Producing the Omega-3 Lipid 12-HEPE from Brown Fat. Cell Metab. 2019 10 01; 30(4):768-783.e7. PMID: 31353262.
  7. Gerlach BD, Marinello M, Heinz J, Rymut N, Sansbury BE, Riley CO, Sadhu S, Hosseini Z, Kojima Y, Tang DD, Leeper NJ, Spite M, Barroso M, Rayner KJ, Fredman G. Resolvin D1 promotes the targeting and clearance of necroptotic cells. Cell Death Differ. 2020 02; 27(2):525-539. PMID: 31222041.
  8. Giannakis N, Sansbury BE, Patsalos A, Hays TT, Riley CO, Han X, Spite M, Nagy L. Publisher Correction: Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration. Nat Immunol. 2019 Jun; 20(6):765-767. PMID: 31048759.
  9. Giannakis N, Sansbury BE, Patsalos A, Hays TT, Riley CO, Han X, Spite M, Nagy L. Dynamic changes to lipid mediators support transitions among macrophage subtypes during muscle regeneration. Nat Immunol. 2019 05; 20(5):626-636. PMID: 30936495.
  10. Spite M. Resolving inflammation in nonalcoholic steatohepatitis. J Clin Invest. 2019 03 11; 129(4):1524-1526. PMID: 30855277.
  11. Ramirez JL, Gasper WJ, Khetani SA, Zahner GJ, Hills NK, Mitchell PT, Sansbury BE, Conte MS, Spite M, Grenon SM. Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial). J Surg Res. 2019 06; 238:164-174. PMID: 30771686.
  12. Wu B, Werlin EC, Chen M, Mottola G, Chatterjee A, Lance KD, Bernards DA, Sansbury BE, Spite M, Desai TA, Conte MS. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rabbit vein graft model. J Vasc Surg. 2018 12; 68(6S):188S-200S.e4. PMID: 30064835.
    Citations: 1     Fields:    
  13. Hellmann J, Sansbury BE, Wong B, Li X, Singh M, Nuutila K, Chiang N, Eriksson E, Serhan CN, Spite M. Biosynthesis of D-Series Resolvins in Skin Provides Insights into their Role in Tissue Repair. J Invest Dermatol. 2018 09; 138(9):2051-2060. PMID: 29559341.
    Citations:    Fields:    
  14. Winkler JW, Libreros S, De La Rosa X, Sansbury BE, Norris PC, Chiang N, Fichtner D, Keyes GS, Wourms N, Spite M, Serhan CN. Structural insights into Resolvin D4 actions and further metabolites via a new total organic synthesis and validation. J Leukoc Biol. 2018 Jan 29. PMID: 29377345.
    Citations: 3     Fields:    
  15. Gromovsky AD, Schugar RC, Brown AL, Helsley RN, Burrows AC, Ferguson D, Zhang R, Sansbury BE, Lee RG, Morton RE, Allende DS, Parks JS, Spite M, Brown JM. ?-5 Fatty Acid Desaturase FADS1 Impacts Metabolic Disease by Balancing Proinflammatory and Proresolving Lipid Mediators. Arterioscler Thromb Vasc Biol. 2018 01; 38(1):218-231. PMID: 29074585.
    Citations: 3     Fields:    Translation:AnimalsCells
  16. Chatterjee A, Komshian S, Sansbury BE, Wu B, Mottola G, Chen M, Spite M, Conte MS. Biosynthesis of proresolving lipid mediators by vascular cells and tissues. FASEB J. 2017 08; 31(8):3393-3402. PMID: 28442547.
    Citations: 3     Fields:    Translation:HumansCells
  17. Fredman G, Spite M. Specialized pro-resolving mediators in cardiovascular diseases. Mol Aspects Med. 2017 Dec; 58:65-71. PMID: 28257820.
    Citations: 3     Fields:    Translation:HumansAnimals
  18. Cai B, Thorp EB, Doran AC, Sansbury BE, Daemen MJ, Dorweiler B, Spite M, Fredman G, Tabas I. MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis. J Clin Invest. 2017 Feb 01; 127(2):564-568. PMID: 28067670.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  19. Varga T, Mounier R, Patsalos A, Gogolák P, Peloquin M, Horvath A, Pap A, Daniel B, Nagy G, Pintye E, Póliska S, Cuvellier S, Larbi SB, Sansbury BE, Spite M, Brown CW, Chazaud B, Nagy L. Macrophage PPAR?, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration. Immunity. 2016 11 15; 45(5):1038-1051. PMID: 27836432.
    Citations: 11     Fields:    Translation:AnimalsCells
  20. Fredman G, Hellmann J, Proto JD, Kuriakose G, Colas RA, Dorweiler B, Connolly ES, Solomon R, Jones DM, Heyer EJ, Spite M, Tabas I. An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. Nat Commun. 2016 Sep 23; 7:12859. PMID: 27659679.
    Citations: 38     Fields:    
  21. Lance KD, Chatterjee A, Wu B, Mottola G, Nuhn H, Lee PP, Sansbury BE, Spite M, Desai TA, Conte MS. Unidirectional and sustained delivery of the proresolving lipid mediator resolvin D1 from a biodegradable thin film device. J Biomed Mater Res A. 2017 01; 105(1):31-41. PMID: 27508346.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  22. Zhang MJ, Sansbury BE, Hellmann J, Baker JF, Guo L, Parmer CM, Prenner JC, Conklin DJ, Bhatnagar A, Creager MA, Spite M. Resolvin D2 Enhances Postischemic Revascularization While Resolving Inflammation. Circulation. 2016 Aug 30; 134(9):666-680. PMID: 27507404.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  23. Sansbury BE, Spite M. Resolution of Acute Inflammation and the Role of Resolvins in Immunity, Thrombosis, and Vascular Biology. Circ Res. 2016 06 24; 119(1):113-30. PMID: 27340271.
    Citations: 11     Fields:    Translation:HumansAnimals
  24. Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, Spite M, Fredman G, Tabas I. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci U S A. 2016 Jun 07; 113(23):6526-31. PMID: 27199481.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  25. Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN, Levy BD. Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol. 2016 07; 186(7):1801-1813. PMID: 27171898.
    Citations: 9     Fields:    Translation:Animals
  26. Hellmann J, Sansbury BE, Holden CR, Tang Y, Wong B, Wysoczynski M, Rodriguez J, Bhatnagar A, Hill BG, Spite M. CCR7 Maintains Nonresolving Lymph Node and Adipose Inflammation in Obesity. Diabetes. 2016 08; 65(8):2268-81. PMID: 27207557.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  27. Berrueta L, Muskaj I, Olenich S, Butler T, Badger GJ, Colas RA, Spite M, Serhan CN, Langevin HM. Stretching Impacts Inflammation Resolution in Connective Tissue. J Cell Physiol. 2016 Jul; 231(7):1621-7. PMID: 26588184.
    Citations: 8     Fields:    Translation:AnimalsCells
  28. Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). J Am Heart Assoc. 2015 Aug 21; 4(8):e002034. PMID: 26296857.
    Citations: 11     Fields:    Translation:Humans
  29. Hellmann J, Tang Y, Zhang MJ, Hai T, Bhatnagar A, Srivastava S, Spite M. Atf3 negatively regulates Ptgs2/Cox2 expression during acute inflammation. Prostaglandins Other Lipid Mediat. 2015 Jan-Mar; 116-117:49-56. PMID: 25619459.
    Citations: 6     Fields:    Translation:AnimalsCells
  30. Spite M. Resolving lipids: lipoxins regulate reverse cholesterol transport. Cell Metab. 2014 Dec 02; 20(6):935-7. PMID: 25470544.
    Citations:    Fields:    Translation:HumansAnimals
  31. Fredman G, Ozcan L, Spolitu S, Hellmann J, Spite M, Backs J, Tabas I. Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway. Proc Natl Acad Sci U S A. 2014 Oct 07; 111(40):14530-5. PMID: 25246560.
    Citations: 36     Fields:    Translation:AnimalsCells
  32. Billeter AT, Hellmann J, Roberts H, Druen D, Gardner SA, Sarojini H, Galandiuk S, Chien S, Bhatnagar A, Spite M, Polk HC. MicroRNA-155 potentiates the inflammatory response in hypothermia by suppressing IL-10 production. FASEB J. 2014 Dec; 28(12):5322-36. PMID: 25231976.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  33. Cummins TD, Holden CR, Sansbury BE, Gibb AA, Shah J, Zafar N, Tang Y, Hellmann J, Rai SN, Spite M, Bhatnagar A, Hill BG. Metabolic remodeling of white adipose tissue in obesity. Am J Physiol Endocrinol Metab. 2014 Aug 01; 307(3):E262-77. PMID: 24918202.
    Citations: 31     Fields:    Translation:AnimalsCells
  34. Nosova EV, Yen P, Chong KC, Alley HF, Stock EO, Quinn A, Hellmann J, Conte MS, Owens CD, Spite M, Grenon SM. Short-term physical inactivity impairs vascular function. J Surg Res. 2014 Aug; 190(2):672-82. PMID: 24630521.
    Citations: 16     Fields:    Translation:Humans
  35. Fredman G, Spite M. Recent advances in the role of immunity in atherosclerosis. Circ Res. 2013 Dec 06; 113(12):e111-4. PMID: 24311619.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Spite M, Clària J, Serhan CN. Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab. 2014 Jan 07; 19(1):21-36. PMID: 24239568.
    Citations: 76     Fields:    Translation:HumansAnimals
  37. Spite M. Deciphering the role of n-3 polyunsaturated fatty acid-derived lipid mediators in health and disease. Proc Nutr Soc. 2013 Nov; 72(4):441-50. PMID: 23991833.
    Citations: 3     Fields:    Translation:Humans
  38. Hellmann J, Zhang MJ, Tang Y, Rane M, Bhatnagar A, Spite M. Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production. J Immunol. 2013 Aug 01; 191(3):1383-92. PMID: 23785121.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  39. Tang Y, Zhang MJ, Hellmann J, Kosuri M, Bhatnagar A, Spite M. Proresolution therapy for the treatment of delayed healing of diabetic wounds. Diabetes. 2013 Feb; 62(2):618-27. PMID: 23043160.
    Citations: 46     Fields:    Translation:AnimalsCells
  40. Sansbury BE, Cummins TD, Tang Y, Hellmann J, Holden CR, Harbeson MA, Chen Y, Patel RP, Spite M, Bhatnagar A, Hill BG. Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype. Circ Res. 2012 Oct 12; 111(9):1176-89. PMID: 22896587.
    Citations: 39     Fields:    Translation:AnimalsCells
  41. Calvert JW, Kevil CG, Spite MR. Regulation and maintenance of vascular tone and patency in cardiovascular health and disease. Int J Vasc Med. 2012; 2012:396369. PMID: 22577553.
  42. Hellmann J, Tang Y, Spite M. Proresolving lipid mediators and diabetic wound healing. Curr Opin Endocrinol Diabetes Obes. 2012 Apr; 19(2):104-8. PMID: 22374140.
    Citations: 8     Fields:    Translation:HumansCells
  43. Zhang MJ, Spite M. Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. Annu Rev Nutr. 2012 Aug 21; 32:203-27. PMID: 22404117.
    Citations: 42     Fields:    Translation:HumansAnimals
  44. Spite M, Hellmann J, Tang Y, Mathis SP, Kosuri M, Bhatnagar A, Jala VR, Haribabu B. Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity. J Immunol. 2011 Aug 15; 187(4):1942-9. PMID: 21742977.
    Citations: 48     Fields:    Translation:AnimalsCells
  45. Spite M, Serhan CN. Lipid signatures of unstable atheromas: fossils or a step toward personalized lipidomics-metabolomics? Circ Cardiovasc Genet. 2011 Jun; 4(3):215-7. PMID: 21673308.
    Citations: 3     Fields:    Translation:HumansAnimals
  46. Hellmann J, Tang Y, Kosuri M, Bhatnagar A, Spite M. Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice. FASEB J. 2011 Jul; 25(7):2399-407. PMID: 21478260.
    Citations: 84     Fields:    Translation:AnimalsCells
  47. Norling LV, Spite M, Yang R, Flower RJ, Perretti M, Serhan CN. Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol. 2011 May 15; 186(10):5543-7. PMID: 21460209.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  48. Spite M, Serhan CN. Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res. 2010 Nov 12; 107(10):1170-84. PMID: 21071715.
    Citations: 97     Fields:    Translation:HumansAnimals
  49. Ho KJ, Spite M, Owens CD, Lancero H, Kroemer AH, Pande R, Creager MA, Serhan CN, Conte MS. Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis. Am J Pathol. 2010 Oct; 177(4):2116-23. PMID: 20709806.
    Citations: 62     Fields:    Translation:HumansCells
  50. Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature. 2009 Oct 29; 461(7268):1287-91. PMID: 19865173.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  51. Srivastava S, Vladykovskaya E, Barski OA, Spite M, Kaiserova K, Petrash JM, Chung SS, Hunt G, Dawn B, Bhatnagar A. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res. 2009 Oct 09; 105(8):793-802. PMID: 19729598.
    Citations: 36     Fields:    Translation:AnimalsCells
  52. Spite M, Summers L, Porter TF, Srivastava S, Bhatnagar A, Serhan CN. Resolvin D1 controls inflammation initiated by glutathione-lipid conjugates formed during oxidative stress. Br J Pharmacol. 2009 Oct; 158(4):1062-73. PMID: 19422383.
    Citations: 37     Fields:    Translation:Animals
  53. Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS, Porter TF, Oh SF, Spite M. Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med. 2009 Jan 16; 206(1):15-23. PMID: 19103881.
    Citations: 195     Fields:    Translation:HumansAnimalsCells
  54. Spite M, Baba SP, Ahmed Y, Barski OA, Nijhawan K, Petrash JM, Bhatnagar A, Srivastava S. Substrate specificity and catalytic efficiency of aldo-keto reductases with phospholipid aldehydes. Biochem J. 2007 Jul 01; 405(1):95-105. PMID: 17381426.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  55. Srivastava S, Spite M, Trent JO, West MB, Ahmed Y, Bhatnagar A. Aldose reductase-catalyzed reduction of aldehyde phospholipids. J Biol Chem. 2004 Dec 17; 279(51):53395-406. PMID: 15465833.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  56. Cayrel R, Hill V, Beers TC, Barbuy B, Spite M, Spite F, Plez B, Andersen J, Bonifacio P, François P, Molaro P, Nordström B, Primas F. Measurement of stellar age from uranium decay. Nature. 2001 Feb 08; 409(6821):691-2. PMID: 11217852.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.