Harvard Catalyst Profiles

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To-Ha Thai, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI137751 (THAI, TO-HA) Dec 1, 2018 - Apr 30, 2021
    Potential role of heterochromatin protein 1? in the control of FOXP3 stability and expression in induced CD4+ regulatory T cells
    Role: Principal Investigator
  2. R21CA198263 (THAI, TO-HA) Apr 1, 2016 - May 31, 2018
    Cbx-3/HP-1gamma deficiency confers anti-tumor immunity
    Role: Principal Investigator
  3. R56AI099012 (THAI, TO-HA) Apr 1, 2012 - Jul 31, 2014
    Regulation of chromatin modifications by miRNAs to control cytokine expression
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Le TP, Thai TH. The State of Cellular Adoptive Immunotherapy for Neuroblastoma and Other Pediatric Solid Tumors. Front Immunol. 2017; 8:1640. PMID: 29225605.
    Citations: 2     Fields:    
  2. Sun M, Ha N, Pham DH, Frederick M, Sharma B, Naruse C, Asano M, Pipkin ME, George RE, Thai TH. Cbx3/HP1? deficiency confers enhanced tumor-killing capacity on CD8+ T cells. Sci Rep. 2017 02 21; 7:42888. PMID: 28220815.
    Citations: 5     Fields:    Translation:AnimalsCells
  3. Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. MiR-150 Controls B Cell Differentiation by Targeting the Transcription Factor c-Myb. Cell. 2016 May 05; 165(4):1027. PMID: 27153500.
    Citations: 4     Fields:    
  4. Ha N, Pham DH, Shahsafaei A, Naruse C, Asano M, Thai TH. HP-1? Controls High-Affinity Antibody Response to T-Dependent Antigens. Front Immunol. 2014; 5:271. PMID: 24971082.
    Citations: 2     Fields:    
  5. Thai TH, Patterson HC, Pham DH, Kis-Toth K, Kaminski DA, Tsokos GC. Deletion of microRNA-155 reduces autoantibody responses and alleviates lupus-like disease in the Fas(lpr) mouse. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20194-9. PMID: 24282294.
    Citations: 42     Fields:    Translation:Animals
  6. Sullivan RP, Fogel LA, Leong JW, Schneider SE, Wong R, Romee R, Thai TH, Sexl V, Matkovich SJ, Dorn GW, French AR, Fehniger TA. MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways. J Immunol. 2013 Dec 15; 191(12):5904-13. PMID: 24227772.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  7. Kannan L, Kis-Toth K, Yoshiya K, Thai TH, Sehrawat S, Mayadas TN, Dalle Lucca JJ, Tsokos GC. R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14348-53. PMID: 23942120.
    Citations: 11     Fields:    Translation:AnimalsCells
  8. Tsokos GC, Thai TH. Interleukin-2 in systemic autoimmunity hits the micro way. Arthritis Rheum. 2012 Nov; 64(11):3494-7. PMID: 22736339.
    Citations: 2     Fields:    Translation:HumansCells
  9. Zhang Y, Roccaro AM, Rombaoa C, Flores L, Obad S, Fernandes SM, Sacco A, Liu Y, Ngo H, Quang P, Azab AK, Azab F, Maiso P, Reagan M, Brown JR, Thai TH, Kauppinen S, Ghobrial IM. LNA-mediated anti-miR-155 silencing in low-grade B-cell lymphomas. Blood. 2012 Aug 23; 120(8):1678-86. PMID: 22797699.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  10. Yoshiya K, Lapchak PH, Thai TH, Kannan L, Rani P, Dalle Lucca JJ, Tsokos GC. Depletion of gut commensal bacteria attenuates intestinal ischemia/reperfusion injury. Am J Physiol Gastrointest Liver Physiol. 2011 Dec; 301(6):G1020-30. PMID: 21903760.
    Citations: 34     Fields:    Translation:Animals
  11. Patterson HC, Kraus M, Wang D, Shahsafaei A, Henderson JM, Seagal J, Otipoby KL, Thai TH, Rajewsky K. Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation. J Immunol. 2011 Sep 15; 187(6):2853-8. PMID: 21841126.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Kis-Toth K, Szanto A, Thai TH, Tsokos GC. Cytosolic DNA-activated human dendritic cells are potent activators of the adaptive immune response. J Immunol. 2011 Aug 01; 187(3):1222-34. PMID: 21709148.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  13. Chatterjee M, Kis-Toth K, Thai TH, Terhorst C, Tsokos GC. SLAMF6-driven co-stimulation of human peripheral T cells is defective in SLE T cells. Autoimmunity. 2011 May; 44(3):211-8. PMID: 21231893.
    Citations: 18     Fields:    Translation:HumansCells
  14. Thai TH, Christiansen PA, Tsokos GC. Is there a link between dysregulated miRNA expression and disease? Discov Med. 2010 Sep; 10(52):184-94. PMID: 20875339.
    Citations: 18     Fields:    Translation:HumansAnimals
  15. Lu LF, Thai TH, Calado DP, Chaudhry A, Kubo M, Tanaka K, Loeb GB, Lee H, Yoshimura A, Rajewsky K, Rudensky AY. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells by targeting SOCS1 protein. Immunity. 2009 Jan 16; 30(1):80-91. PMID: 19144316.
    Citations: 356     Fields:    Translation:HumansAnimalsCells
  16. Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity. 2008 May; 28(5):630-8. PMID: 18455451.
    Citations: 217     Fields:    Translation:AnimalsCells
  17. Xiao C, Calado DP, Galler G, Thai TH, Patterson HC, Wang J, Rajewsky N, Bender TP, Rajewsky K. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007 Oct 05; 131(1):146-59. PMID: 17923094.
    Citations: 465     Fields:    Translation:HumansAnimalsCells
  18. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K. Regulation of the germinal center response by microRNA-155. Science. 2007 Apr 27; 316(5824):604-8. PMID: 17463289.
    Citations: 657     Fields:    Translation:AnimalsCells
  19. Monticelli S, Ansel KM, Xiao C, Socci ND, Krichevsky AM, Thai TH, Rajewsky N, Marks DS, Sander C, Rajewsky K, Rao A, Kosik KS. MicroRNA profiling of the murine hematopoietic system. Genome Biol. 2005; 6(8):R71. PMID: 16086853.
    Citations: 177     Fields:    Translation:Animals
  20. Thai TH, Kearney JF. Distinct and opposite activities of human terminal deoxynucleotidyltransferase splice variants. J Immunol. 2004 Sep 15; 173(6):4009-19. PMID: 15356150.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  21. Thai TH, Purugganan MM, Roth DB, Kearney JF. Distinct and opposite diversifying activities of terminal transferase splice variants. Nat Immunol. 2002 May; 3(5):457-62. PMID: 11938351.
    Citations: 16     Fields:    Translation:AnimalsCells
  22. Benedict CL, Gilfillan S, Thai TH, Kearney JF. Terminal deoxynucleotidyl transferase and repertoire development. Immunol Rev. 2000 Jun; 175:150-7. PMID: 10933600.
    Citations: 62     Fields:    Translation:AnimalsCells
  23. Thai TH, Fultz PN. Down-modulation of the ZAP-70 protein tyrosine kinase in macaque T lymphocytes infected with SIVsmmPBj14. J Med Primatol. 1998 Apr-Jun; 27(2-3):141-7. PMID: 9747955.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Tsai AY, Itoh M, Streuli M, Thai T, Saito H. Isolation and characterization of temperature-sensitive and thermostable mutants of the human receptor-like protein tyrosine phosphatase LAR. J Biol Chem. 1991 Jun 05; 266(16):10534-43. PMID: 1645351.
    Citations: 13     Fields:    Translation:HumansCells
  25. Streuli M, Krueger NX, Thai T, Tang M, Saito H. Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR. EMBO J. 1990 Aug; 9(8):2399-407. PMID: 1695146.
    Citations: 92     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.