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Kingston, Robert
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Robert Edward Kingston, Ph.D.
Title
Professor of Genetics
Institution
Massachusetts General Hospital
Department
Genetics
Address
Massachusetts General Hospital
Chief, Dept. of Molecular Biology, CPZN7250
185 Cambridge St
Boston MA 02114
Phone
617/726-5990
Fax
617/726-5949
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R35GM131743
(KINGSTON, ROBERT)
Apr 1, 2019 - Mar 31, 2024
NIH
Functional Analysis of Epigenetic Complexes
Role: Principal Investigator
R13CA132255
(KINGSTON, ROBERT)
Apr 1, 2008 - Mar 31, 2011
NIH
2008 Chromatin Structure and Function Gordon Research Conference
Role: Principal Investigator
R01HG003141
(KINGSTON, ROBERT)
Sep 30, 2003 - Aug 31, 2007
NIH
Long-range High-resolution Mapping of Chromatin
Role: Principal Investigator
R01GM061350
(KINGSTON, ROBERT)
Mar 1, 2000 - Feb 29, 2004
NIH
CHARACTERIZATION OF POLYCOMB GROUP COMPLEXES
Role: Principal Investigator
R37GM048405
(KINGSTON, ROBERT)
Jan 1, 1993 - Dec 31, 2018
NIH
Transcription Factor Interactions with Nucleosomes
Role: Principal Investigator
R01GM048405
(KINGSTON, ROBERT)
Jan 1, 1993 - Dec 31, 2008
NIH
Transcription Factor Interactions with Nucleosomes
Role: Principal Investigator
R01GM043901
(KINGSTON, ROBERT)
May 1, 1991 - May 31, 2020
NIH
Maintenance of Gene Expression
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Kim JJ,
Kingston RE
. Context-specific Polycomb mechanisms in development. Nat Rev Genet. 2022 11; 23(11):680-695.
PMID:
35681061
.
Citations:
Fields:
Gen
Genetics
Tchasovnikarova IA, Marr SK, Damle M,
Kingston RE
. TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways. Mol Cell. 2022 01 20; 82(2):479-491.e7.
PMID:
34963054
; PMCID:
PMC8796053
.
Citations:
1
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Valcourt JR, Huang RE, Kundu S, Venkatasubramanian D,
Kingston RE
,
Ramanathan S
. Modulating mesendoderm competence during human germ layer differentiation. Cell Rep. 2021 11 09; 37(6):109990.
PMID:
34758327
; PMCID:
PMC8601596
.
Citations:
1
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Hsieh FK, Ji F, Damle M,
Sadreyev RI
,
Kingston RE
. HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7. Life Sci Alliance. 2022 01; 5(1).
PMID:
34663690
; PMCID:
PMC8548210
.
Citations:
Fields:
Bio
Biochemistry
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Jaensch ES, Zhu J, Cochrane JC, Marr SK, Oei TA, Damle M, McCaslin EZ,
Kingston RE
. A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells. Mol Cell. 2021 11 18; 81(22):4677-4691.e8.
PMID:
34637753
; PMCID:
PMC8966356
.
Citations:
1
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Kingston R
, Sioris K, Gualtieri J, Brutlag A, Droege W, Osimitz TG. Post-market surveillance of consumer products: Framework for adverse event management. Regul Toxicol Pharmacol. 2021 Nov; 126:105028.
PMID:
34481892
.
Citations:
Fields:
Pha
Pharmacology
Tox
Toxicology
Translation:
PH
Public Health
Miller SA, Damle M, Kim J,
Kingston RE
. Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity. Development. 2021 Apr 01; 148(7).
PMID:
34437687
.
Citations:
Fields:
Bio
Biology
Emb
Embryology
Miller SA, Damle M, Kim J,
Kingston RE
. Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity. Development. 2021 04 01; 148(7).
PMID:
33688077
; PMCID:
PMC8077505
.
Citations:
2
Fields:
Bio
Biology
Emb
Embryology
Translation:
Animals
Cells
Ardehali MB, Damle M, Perea-Resa C, Blower MD,
Kingston RE
. Elongin A associates with actively transcribed genes and modulates enhancer RNA levels with limited impact on transcription elongation rate in vivo. J Biol Chem. 2021 Jan-Jun; 296:100202.
PMID:
33334895
.
Citations:
7
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Wang Y, Hou L, Ardehali MB,
Kingston RE
, Dynlacht BD. Elongin A regulates transcription in vivo through enhanced RNA polymerase processivity. J Biol Chem. 2021 Jan-Jun; 296:100170.
PMID:
33298525
.
Citations:
3
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Daneshvar K, Ardehali MB, Klein IA, Hsieh FK, Kratkiewicz AJ,
Mahpour A
, Cancelliere SOL, Zhou C, Cook BM, Li W, Pondick JV,
Gupta SK
, Moran SP, Young RA,
Kingston RE
,
Mullen AC
. lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation. Nat Cell Biol. 2020 10; 22(10):1211-1222.
PMID:
32895492
; PMCID:
PMC8008247
.
Citations:
35
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Guillen Sacoto MJ, Tchasovnikarova IA, Torti E, Forster C, Andrew EH,
Anselm I
, Baranano KW, Briere LC, Cohen JS, Craigen WJ, Cytrynbaum C, Ekhilevitch N, Elrick MJ, Fatemi A, Fraser JL, Gallagher RC, Guerin A, Haynes D,
High FA
, Inglese CN, Kiss C, Koenig MK,
Krier J
, Lindstrom K, Marble M, Meddaugh H, Moran ES, Morel CF, Mu W, Muller EA, Nance J, Natowicz MR, Numis AL, Ostrem B, Pappas J, Stafstrom CE, Streff H,
Sweetser DA
, Szybowska M,
Walker MA
, Wang W, Weiss K, Weksberg R, Wheeler PG, Yoon G,
Kingston RE
, Juusola J. De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism. Am J Hum Genet. 2020 08 06; 107(2):352-363.
PMID:
32693025
.
Citations:
21
Fields:
Gen
Genetics
Translation:
Humans
Yildirim O, Izgu EC, Damle M, Chalei V, Ji F,
Sadreyev RI
,
Szostak JW
,
Kingston RE
. S-phase Enriched Non-coding RNAs Regulate Gene Expression and Cell Cycle Progression. Cell Rep. 2020 05 12; 31(6):107629.
PMID:
32402276
.
Citations:
4
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Kim J,
Kingston RE
. The CBX family of proteins in transcriptional repression and memory. J Biosci. 2020; 45.
PMID:
31965994
.
Citations:
9
Fields:
Bio
Biochemistry
Bio
Biology
Translation:
Humans
Cells
Abdusselamoglu MD, Landskron L, Bowman SK, Eroglu E, Burkard T,
Kingston RE
, Knoblich JA. Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors. Development. 2019 12 02; 146(23).
PMID:
31748204
; PMCID:
PMC7055365
.
Citations:
2
Fields:
Bio
Biology
Emb
Embryology
Translation:
Animals
Cells
Plys AJ,
Davis CP
, Kim J, Rizki G, Keenen MM, Marr SK,
Kingston RE
. Phase separation of Polycomb-repressive complex 1 is governed by a charged disordered region of CBX2. Genes Dev. 2019 07 01; 33(13-14):799-813.
PMID:
31171700
; PMCID:
PMC6601514
.
Citations:
122
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Gopalakrishnan R, Marr SK,
Kingston RE
,
Winston F
. A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation. Nucleic Acids Res. 2019 05 07; 47(8):3888-3903.
PMID:
30793188
; PMCID:
PMC6486648
.
Citations:
10
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Jégu T,
Blum R
, Cochrane JC, Yang L, Wang CY, Gilles ME, Colognori D, Szanto A, Marr SK,
Kingston RE
, Lee JT. Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome. Nat Struct Mol Biol. 2019 02; 26(2):96-109.
PMID:
30664740
; PMCID:
PMC6421574
.
Citations:
22
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Plys AJ,
Kingston RE
. Dynamic condensates activate transcription. Science. 2018 07 27; 361(6400):329-330.
PMID:
30049863
.
Citations:
28
Fields:
Sci
Science
Kundu S, Ji F, Sunwoo H, Jain G, Lee JT,
Sadreyev RI
, Dekker J,
Kingston RE
. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell. 2018 07 05; 71(1):191.
PMID:
29979966
; PMCID:
PMC6261330
.
Citations:
10
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Tchasovnikarova IA,
Kingston RE
. Beyond the Histone Code: A Physical Map of Chromatin States. Mol Cell. 2018 01 04; 69(1):5-7.
PMID:
29304334
.
Citations:
5
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Cells
Ardehali MB, Anselmo A, Cochrane JC, Kundu S,
Sadreyev RI
,
Kingston RE
. Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription. Mol Cell. 2017 Dec 07; 68(5):872-884.e6.
PMID:
29153392
; PMCID:
PMC5800316
.
Citations:
34
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Urban J, Kuzu G, Bowman S, Scruggs B, Henriques T,
Kingston R
,
Adelman K
, Tolstorukov M, Larschan E. Enhanced chromatin accessibility of the dosage compensated Drosophila male X-chromosome requires the CLAMP zinc finger protein. PLoS One. 2017; 12(10):e0186855.
PMID:
29077765
.
Citations:
14
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Tchasovnikarova IA, Timms RT, Douse CH, Roberts RC, Dougan G,
Kingston RE
, Modis Y, Lehner PJ. Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Nat Genet. 2017 Jul; 49(7):1035-1044.
PMID:
28581500
.
Citations:
50
Fields:
Gen
Genetics
Translation:
Humans
Cells
Jaensch ES, Kundu S,
Kingston RE
. Multitasking by Polycomb response elements. Genes Dev. 2017 06 01; 31(11):1069-1072.
PMID:
28717045
; PMCID:
PMC5538430
.
Citations:
3
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Lau MS, Schwartz MG, Kundu S, Savol AJ, Wang PI, Marr SK, Grau DJ, Schorderet P,
Sadreyev RI
,
Tabin CJ
,
Kingston RE
. Mutation of a nucleosome compaction region disrupts Polycomb-mediated axial patterning. Science. 2017 03 10; 355(6329):1081-1084.
PMID:
28280206
.
Citations:
61
Fields:
Sci
Science
Translation:
Animals
Cells
Mueller B, Mieczkowski J, Kundu S, Wang P,
Sadreyev R
, Tolstorukov MY,
Kingston RE
. Widespread changes in nucleosome accessibility without changes in nucleosome occupancy during a rapid transcriptional induction. Genes Dev. 2017 03 01; 31(5):451-462.
PMID:
28356342
; PMCID:
PMC5393060
.
Citations:
47
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Kundu S, Ji F, Sunwoo H, Jain G,
Lee JT
,
Sadreyev RI
, Dekker J,
Kingston RE
. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell. 2017 Feb 02; 65(3):432-446.e5.
PMID:
28157505
; PMCID:
PMC5421375
.
Citations:
118
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Pulivarthy SR, Lion M, Kuzu G, Matthews AG, Borowsky ML, Morris J,
Kingston RE
, Dennis JH, Tolstorukov MY,
Oettinger MA
. Regulated large-scale nucleosome density patterns and precise nucleosome positioning correlate with V(D)J recombination. Proc Natl Acad Sci U S A. 2016 10 18; 113(42):E6427-E6436.
PMID:
27698124
; PMCID:
PMC5081657
.
Citations:
13
Fields:
Sci
Science
Translation:
Animals
Cells
West JA, Mito M, Kurosaka S, Takumi T, Tanegashima C, Chujo T, Yanaka K,
Kingston RE
, Hirose T, Bond C, Fox A, Nakagawa S. Structural, super-resolution microscopy analysis of paraspeckle nuclear body organization. J Cell Biol. 2016 09 26; 214(7):817-30.
PMID:
27646274
; PMCID:
PMC5037409
.
Citations:
105
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Ray MK, Wiskow O, King MJ, Ismail N, Ergun A, Wang Y, Plys AJ,
Davis CP
, Kathrein K,
Sadreyev R
, Borowsky ML, Eggan K,
Zon L
,
Galloway JL
,
Kingston RE
. CAT7 and cat7l Long Non-coding RNAs Tune Polycomb Repressive Complex 1 Function during Human and Zebrafish Development. J Biol Chem. 2016 09 09; 291(37):19558-72.
PMID:
27405765
.
Citations:
15
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Deaton AM, Gómez-RodrÃguez M, Mieczkowski J, Tolstorukov MY, Kundu S,
Sadreyev RI
, Jansen LE,
Kingston RE
. Enhancer regions show high histone H3.3 turnover that changes during differentiation. Elife. 2016 06 15; 5.
PMID:
27304074
.
Citations:
33
Fields:
Bio
Biology
Translation:
Animals
Cells
Mieczkowski J, Cook A, Bowman SK, Mueller B, Alver BH, Kundu S, Deaton AM, Urban JA, Larschan E,
Park PJ
,
Kingston RE
, Tolstorukov MY. MNase titration reveals differences between nucleosome occupancy and chromatin accessibility. Nat Commun. 2016 05 06; 7:11485.
PMID:
27151365
.
Citations:
92
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Yildirim O,
Kingston RE
. Molecular Dissection of Chromatin Maturation via Click Chemistry. Curr Protoc Mol Biol. 2016 Apr 01; 114:21.33.1-21.33.11.
PMID:
27038388
.
Citations:
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Wani AH, Boettiger AN, Schorderet P, Ergun A, Münger C,
Sadreyev RI
, Zhuang X,
Kingston RE
, Francis NJ. Chromatin topology is coupled to Polycomb group protein subnuclear organization. Nat Commun. 2016 Jan 13; 7:10291.
PMID:
26759081
.
Citations:
77
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Cajigas I, Leib DE, Cochrane J, Luo H, Swyter KR, Chen S, Clark BS, Thompson J, Yates JR,
Kingston RE
, Kohtz JD. Evf2 lncRNA/BRG1/DLX1 interactions reveal RNA-dependent inhibition of chromatin remodeling. Development. 2015 Aug 01; 142(15):2641-52.
PMID:
26138476
.
Citations:
46
Fields:
Bio
Biology
Emb
Embryology
Translation:
Humans
Animals
Cells
Lei I, West J, Yan Z, Gao X, Fang P, Dennis JH, Gnatovskiy L, Wang W,
Kingston RE
, Wang Z. BAF250a Protein Regulates Nucleosome Occupancy and Histone Modifications in Priming Embryonic Stem Cell Differentiation. J Biol Chem. 2015 Jul 31; 290(31):19343-52.
PMID:
26070559
.
Citations:
24
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Kingston RE
, Tamkun JW. Transcriptional regulation by trithorax-group proteins. Cold Spring Harb Perspect Biol. 2014 Oct 01; 6(10):a019349.
PMID:
25274705
.
Citations:
43
Fields:
Bio
Biology
Translation:
Humans
Animals
Ho JW,
Jung YL
, Liu T, Alver BH, Lee S, Ikegami K, Sohn KA, Minoda A, Tolstorukov MY, Appert A, Parker SC, Gu T, Kundaje A, Riddle NC, Bishop E, Egelhofer TA, Hu SS, Alekseyenko AA, Rechtsteiner A, Asker D, Belsky JA, Bowman SK, Chen QB, Chen RA, Day DS, Dong Y, Dose AC, Duan X, Epstein CB, Ercan S, Feingold EA, Ferrari F, Garrigues JM,
Gehlenborg N
, Good PJ, Haseley P, He D, Herrmann M, Hoffman MM, Jeffers TE,
Kharchenko PV
, Kolasinska-Zwierz P, Kotwaliwale CV, Kumar N, Langley SA, Larschan EN, Latorre I, Libbrecht MW, Lin X, Park R, Pazin MJ, Pham HN, Plachetka A, Qin B, Schwartz YB, Shoresh N, Stempor P, Vielle A, Wang C, Whittle CM, Xue H,
Kingston RE
, Kim JH,
Bernstein BE
, Dernburg AF, Pirrotta V,
Kuroda MI
, Noble WS, Tullius TD, Kellis M, MacAlpine DM, Strome S, Elgin SC, Liu XS, Lieb JD, Ahringer J, Karpen GH,
Park PJ
. Comparative analysis of metazoan chromatin organization. Nature. 2014 Aug 28; 512(7515):449-52.
PMID:
25164756
.
Citations:
182
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
West JA, Cook A, Alver BH, Stadtfeld M, Deaton AM,
Hochedlinger K
,
Park PJ
, Tolstorukov MY,
Kingston RE
. Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming. Nat Commun. 2014 Aug 27; 5:4719.
PMID:
25158628
; PMCID:
PMC4217530
.
Citations:
48
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
West JA,
Davis CP
, Sunwoo H, Simon MD,
Sadreyev RI
, Wang PI, Tolstorukov MY,
Kingston RE
. The long noncoding RNAs NEAT1 and MALAT1 bind active chromatin sites. Mol Cell. 2014 Sep 04; 55(5):791-802.
PMID:
25155612
.
Citations:
309
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Bowman SK, Deaton AM, Domingues H, Wang PI,
Sadreyev RI
,
Kingston RE
,
Bender W
. H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex. Elife. 2014 Jul 31; 3:e02833.
PMID:
25082344
.
Citations:
53
Fields:
Bio
Biology
Translation:
Animals
Cells
Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J,
Kingston RE
, Fischle W, Warren ST,
Page DC
, Shi Y. A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response. Cell. 2014 May 08; 157(4):869-81.
PMID:
24813610
.
Citations:
71
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Sexton BS, Avey D, Druliner BR, Fincher JA, Vera DL, Grau DJ, Borowsky ML, Gupta S, Girimurugan SB, Chicken E, Zhang J, Noble WS, Zhu F,
Kingston RE
, Dennis JH. The spring-loaded genome: nucleosome redistributions are widespread, transient, and DNA-directed. Genome Res. 2014 Feb; 24(2):251-9.
PMID:
24310001
.
Citations:
21
Fields:
Gen
Genetics
Translation:
Humans
Cells
Simon MD, Pinter SF, Fang R, Sarma K, Rutenberg-Schoenberg M, Bowman SK,
Kesner BA
, Maier VK,
Kingston RE
,
Lee JT
. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature. 2013 Dec 19; 504(7480):465-469.
PMID:
24162848
.
Citations:
200
Fields:
Sci
Science
Translation:
Animals
Cells
Bouazoune K,
Kingston RE
. Assembly, remodelled. Elife. 2013 Aug 20; 2:e01270.
PMID:
23986864
.
Citations:
1
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Toiber D, Erdel F, Bouazoune K, Silberman DM, Zhong L, Mulligan P, Sebastian C, Cosentino C, Martinez-Pastor B, Giacosa S, D'Urso A, Näär AM,
Kingston R
, Rippe K,
Mostoslavsky R
. SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling. Mol Cell. 2013 Aug 22; 51(4):454-68.
PMID:
23911928
.
Citations:
182
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Bowman SK, Simon MD, Deaton AM, Tolstorukov M, Borowsky ML,
Kingston RE
. Multiplexed Illumina sequencing libraries from picogram quantities of DNA. BMC Genomics. 2013 Jul 09; 14:466.
PMID:
23837789
.
Citations:
48
Fields:
Gen
Genetics
Woo CJ,
Kharchenko PV
, Daheron L,
Park PJ
,
Kingston RE
. Variable requirements for DNA-binding proteins at polycomb-dependent repressive regions in human HOX clusters. Mol Cell Biol. 2013 Aug; 33(16):3274-85.
PMID:
23775117
.
Citations:
23
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Riedel CG, Dowen RH, Lourenco GF, Kirienko NV, Heimbucher T, West JA, Bowman SK,
Kingston RE
, Dillin A,
Asara JM
,
Ruvkun G
. DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol. 2013 May; 15(5):491-501.
PMID:
23604319
.
Citations:
96
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Simon JA,
Kingston RE
. Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put. Mol Cell. 2013 Mar 07; 49(5):808-24.
PMID:
23473600
.
Citations:
362
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Fang R, Chen F, Dong Z,
Hu D
, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H,
Kaiser UB
,
Kingston RE
, Xu Y, Shi YG. LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation. Mol Cell. 2013 Feb 07; 49(3):558-70.
PMID:
23260659
; PMCID:
PMC3625064
.
Citations:
34
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Bouazoune K,
Kingston RE
. Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):19238-43.
PMID:
23134727
.
Citations:
65
Fields:
Sci
Science
Translation:
Humans
Cells
Tolstorukov MY, Goldman JA, Gilbert C, Ogryzko V,
Kingston RE
,
Park PJ
. Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cells. Mol Cell. 2012 Aug 24; 47(4):596-607.
PMID:
22795134
.
Citations:
48
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Antão JM, Mason JM, Déjardin J,
Kingston RE
. Protein landscape at Drosophila melanogaster telomere-associated sequence repeats. Mol Cell Biol. 2012 Jun; 32(12):2170-82.
PMID:
22493064
.
Citations:
19
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Simon MD, Wang CI,
Kharchenko PV
, West JA, Chapman BA, Alekseyenko AA, Borowsky ML,
Kuroda MI
,
Kingston RE
. The genomic binding sites of a noncoding RNA. Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20497-502.
PMID:
22143764
.
Citations:
231
Fields:
Sci
Science
Translation:
Animals
Cells
Armache KJ, Garlick JD, Canzio D, Narlikar GJ,
Kingston RE
. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Ã… resolution. Science. 2011 Nov 18; 334(6058):977-82.
PMID:
22096199
.
Citations:
144
Fields:
Sci
Science
Translation:
Animals
Cells
Grau DJ, Chapman BA, Garlick JD, Borowsky M, Francis NJ,
Kingston RE
. Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge. Genes Dev. 2011 Oct 15; 25(20):2210-21.
PMID:
22012622
.
Citations:
106
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Grau DJ, Antao JM,
Kingston RE
. Functional dissection of Polycomb repressive complex 1 reveals the importance of a charged domain. Cold Spring Harb Symp Quant Biol. 2010; 75:61-70.
PMID:
21502414
.
Citations:
5
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Zhao J,
Ohsumi TK
, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ,
Kingston RE
, Borowsky M,
Lee JT
. Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell. 2010 Dec 22; 40(6):939-53.
PMID:
21172659
.
Citations:
516
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Koh AS,
Kingston RE
,
Benoist C
,
Mathis D
. Global relevance of Aire binding to hypomethylated lysine-4 of histone-3. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13016-21.
PMID:
20615959
.
Citations:
32
Fields:
Sci
Science
Translation:
Animals
Cells
Woo CJ,
Kharchenko PV
, Daheron L,
Park PJ
,
Kingston RE
. A region of the human HOXD cluster that confers polycomb-group responsiveness. Cell. 2010 Jan 08; 140(1):99-110.
PMID:
20085705
.
Citations:
164
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Lavigne M, Eskeland R, Azebi S, Saint-André V, Jang SM, Batsché E, Fan HY,
Kingston RE
, Imhof A, Muchardt C. Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression. PLoS Genet. 2009 Dec; 5(12):e1000769.
PMID:
20011120
.
Citations:
39
Fields:
Gen
Genetics
Translation:
Humans
Cells
Goldman JA, Garlick JD,
Kingston RE
. Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z. J Biol Chem. 2010 Feb 12; 285(7):4645-51.
PMID:
19940112
.
Citations:
34
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Seong IS
, Woda JM, Song JJ, Lloret A, Abeyrathne PD, Woo CJ, Gregory G, Lee JM,
Wheeler VC
, Walz T,
Kingston RE
,
Gusella JF
, Conlon RA,
MacDonald ME
. Huntingtin facilitates polycomb repressive complex 2. Hum Mol Genet. 2010 Feb 15; 19(4):573-83.
PMID:
19933700
.
Citations:
87
Fields:
Gen
Genetics
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Simon JA,
Kingston RE
. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol. 2009 Oct; 10(10):697-708.
PMID:
19738629
.
Citations:
708
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Lau NC,
Ohsumi T
, Borowsky M,
Kingston RE
, Blower MD. Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi. EMBO J. 2009 Oct 07; 28(19):2945-58.
PMID:
19713941
.
Citations:
39
Fields:
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Animals
Cells
Bouazoune K, Miranda TB, Jones PA,
Kingston RE
. Analysis of individual remodeled nucleosomes reveals decreased histone-DNA contacts created by hSWI/SNF. Nucleic Acids Res. 2009 Sep; 37(16):5279-94.
PMID:
19567737
.
Citations:
23
Fields:
Bio
Biochemistry
Translation:
Cells
Mortensen RM,
Kingston RE
. Selection of transfected mammalian cells. Curr Protoc Mol Biol. 2009 Apr; Chapter 9:Unit9.5.
PMID:
19343709
.
Citations:
7
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Tolstorukov MY,
Kharchenko PV
, Goldman JA,
Kingston RE
,
Park PJ
. Comparative analysis of H2A.Z nucleosome organization in the human and yeast genomes. Genome Res. 2009 Jun; 19(6):967-77.
PMID:
19246569
.
Citations:
53
Fields:
Gen
Genetics
Translation:
Humans
Cells
Déjardin J,
Kingston RE
. Purification of proteins associated with specific genomic Loci. Cell. 2009 Jan 09; 136(1):175-86.
PMID:
19135898
.
Citations:
262
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Song JJ,
Kingston RE
. WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket. J Biol Chem. 2008 Dec 12; 283(50):35258-64.
PMID:
18840606
.
Citations:
91
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Koh AS, Kuo AJ, Park SY, Cheung P, Abramson J, Bua D, Carney D,
Shoelson SE
, Gozani O,
Kingston RE
,
Benoist C
,
Mathis D
. Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15878-83.
PMID:
18840680
; PMCID:
PMC2572939
.
Citations:
83
Fields:
Sci
Science
Translation:
Animals
Cells
Madhani HD, Francis NJ,
Kingston RE
, Kornberg RD,
Moazed D
, Narlikar GJ, Panning B,
Struhl K
. Epigenomics: a roadmap, but to where? Science. 2008 Oct 03; 322(5898):43-4.
PMID:
18832628
.
Citations:
14
Fields:
Sci
Science
Translation:
Cells
Gupta S, Dennis J, Thurman RE,
Kingston R
, Stamatoyannopoulos JA, Noble WS. Predicting human nucleosome occupancy from primary sequence. PLoS Comput Biol. 2008 Aug 22; 4(8):e1000134.
PMID:
18725940
.
Citations:
56
Fields:
Com
Computational Biology
Translation:
Humans
Animals
Cells
Kharchenko PV
, Woo CJ, Tolstorukov MY,
Kingston RE
,
Park PJ
. Nucleosome positioning in human HOX gene clusters. Genome Res. 2008 Oct; 18(10):1554-61.
PMID:
18723689
.
Citations:
20
Fields:
Gen
Genetics
Translation:
Humans
Cells
He X, Fan HY, Garlick JD,
Kingston RE
. Diverse regulation of SNF2h chromatin remodeling by noncatalytic subunits. Biochemistry. 2008 Jul 08; 47(27):7025-33.
PMID:
18553938
.
Citations:
25
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
O'Toole P, Butt A, Orakzai S, McIntyre A, Callender O,
Kingston R
, Moore D, Fogarty E, Dowling F. Epidemiology of sporting and recreational injuries in a paediatric orthopaedic outpatients department. Ir Med J. 2008 Jun; 101(6):173-4.
PMID:
18700510
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Song JJ, Garlick JD,
Kingston RE
. Structural basis of histone H4 recognition by p55. Genes Dev. 2008 May 15; 22(10):1313-8.
PMID:
18443147
.
Citations:
82
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Trotter KW, Fan HY, Ivey ML,
Kingston RE
, Archer TK. The HSA domain of BRG1 mediates critical interactions required for glucocorticoid receptor-dependent transcriptional activation in vivo. Mol Cell Biol. 2008 Feb; 28(4):1413-26.
PMID:
18086889
.
Citations:
33
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Dunn RK,
Kingston RE
. Gene regulation in the postgenomic era: technology takes the wheel. Mol Cell. 2007 Dec 14; 28(5):708-14.
PMID:
18082595
.
Citations:
11
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Kingston R
, Burke F, Robinson JH, Bedford PA, Jones SM, Knight SC, Williamson ED. The fraction 1 and V protein antigens of Yersinia pestis activate dendritic cells to induce primary T cell responses. Clin Exp Immunol. 2007 Sep; 149(3):561-9.
PMID:
17645768
; PMCID:
PMC2219336
.
Citations:
8
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Woo CJ,
Kingston RE
. HOTAIR lifts noncoding RNAs to new levels. Cell. 2007 Jun 29; 129(7):1257-9.
PMID:
17604716
.
Citations:
60
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Seto AG,
Kingston RE
, Lau NC. The coming of age for Piwi proteins. Mol Cell. 2007 Jun 08; 26(5):603-9.
PMID:
17560367
.
Citations:
119
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Dennis JH, Fan HY, Reynolds SM, Yuan G, Meldrim JC, Richter DJ, Peterson DG, Rando OJ, Noble WS,
Kingston RE
. Independent and complementary methods for large-scale structural analysis of mammalian chromatin. Genome Res. 2007 Jun; 17(6):928-39.
PMID:
17568008
; PMCID:
PMC1891351
.
Citations:
24
Fields:
Gen
Genetics
Translation:
Humans
Cells
Zhang Z, Fan HY, Goldman JA,
Kingston RE
. Homology-driven chromatin remodeling by human RAD54. Nat Struct Mol Biol. 2007 May; 14(5):397-405.
PMID:
17417655
.
Citations:
43
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
He X, Fan HY, Narlikar GJ,
Kingston RE
. Human ACF1 alters the remodeling strategy of SNF2h. J Biol Chem. 2006 Sep 29; 281(39):28636-47.
PMID:
16877760
.
Citations:
38
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP,
Kingston RE
. Characterization of the piRNA complex from rat testes. Science. 2006 Jul 21; 313(5785):363-7.
PMID:
16778019
.
Citations:
424
Fields:
Sci
Science
Translation:
Animals
Cells
Mahajan MC, Narlikar GJ, Boyapaty G,
Kingston RE
, Weissman SM. Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15012-7.
PMID:
16217013
; PMCID:
PMC1257739
.
Citations:
31
Fields:
Sci
Science
Translation:
Humans
Cells
King IF, Emmons RB, Francis NJ, Wild B, Müller J,
Kingston RE
,
Wu CT
. Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function. Mol Cell Biol. 2005 Aug; 25(15):6578-91.
PMID:
16024794
; PMCID:
PMC1190323
.
Citations:
45
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Fan HY, Trotter KW, Archer TK,
Kingston RE
. Swapping function of two chromatin remodeling complexes. Mol Cell. 2005 Mar 18; 17(6):805-15.
PMID:
15780937
.
Citations:
51
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Francis NJ,
Kingston RE
, Woodcock CL. Chromatin compaction by a polycomb group protein complex. Science. 2004 Nov 26; 306(5701):1574-7.
PMID:
15567868
.
Citations:
360
Fields:
Sci
Science
Translation:
Humans
Cells
Levine SS, King IF,
Kingston RE
. Division of labor in polycomb group repression. Trends Biochem Sci. 2004 Sep; 29(9):478-85.
PMID:
15337121
.
Citations:
86
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Peterson AJ, Mallin DR, Francis NJ, Ketel CS, Stamm J, Voeller RK,
Kingston RE
, Simon JA. Requirement for sex comb on midleg protein interactions in Drosophila polycomb group repression. Genetics. 2004 Jul; 167(3):1225-39.
PMID:
15280237
.
Citations:
32
Fields:
Gen
Genetics
Translation:
Animals
Cells
Trinklein ND, Chen WC,
Kingston RE
, Myers RM. Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation. Cell Stress Chaperones. 2004 Mar; 9(1):21-8.
PMID:
15270074
; PMCID:
PMC1065302
.
Citations:
50
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Lavigne M, Francis NJ, King IF,
Kingston RE
. Propagation of silencing; recruitment and repression of naive chromatin in trans by polycomb repressed chromatin. Mol Cell. 2004 Feb 13; 13(3):415-25.
PMID:
14967148
.
Citations:
36
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Fan HY, Narlikar GJ,
Kingston RE
. Noncovalent modification of chromatin: different remodeled products with different ATPase domains. Cold Spring Harb Symp Quant Biol. 2004; 69:183-92.
PMID:
16117648
.
Citations:
13
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Mulholland NM, King IF,
Kingston RE
. Regulation of Polycomb group complexes by the sequence-specific DNA binding proteins Zeste and GAGA. Genes Dev. 2003 Nov 15; 17(22):2741-6.
PMID:
14630938
; PMCID:
PMC280622
.
Citations:
26
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Alexander JL, Rustom R, Herrington CS,
Kingston RE
, Bone JM. Nephroquiz: a woman with renal failure, ureteric obstruction and vasculitic rash. Nephrol Dial Transplant. 2003 Nov; 18(11):2439-41.
PMID:
14551383
.
Citations:
Fields:
Nep
Nephrology
Tra
Transplantation
Translation:
Humans
Kapoor DS, Tincello DG,
Kingston RE
. Life-threatening obstetric haemorrhage in second trimester from a placenta percreta with raised alpha-fetoprotein levels. J Obstet Gynaecol. 2003 Sep; 23(5):570-1.
PMID:
12963529
.
Citations:
Fields:
Gyn
Gynecology
Obs
Obstetrics
Translation:
Humans
Kingston RE
, Chen CA, Rose JK. Calcium phosphate transfection. Curr Protoc Mol Biol. 2003 Aug; Chapter 9:Unit 9.1.
PMID:
18265332
.
Citations:
62
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells