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Stelios Manolis Smirnakis, Ph.D., M.D.

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Mentoring
Available: 02/18/22, Expires: 03/01/24

Experimental and theoretical study of how cortical circuits malfunction in the MECP2-duplication syndrome of autism. Topics: information processing along the cortical column, cortical circuit plasticity during learning, and mechanisms of bistable visual perception. Mesoscopic 2-photon imaging to record from multitple cortical layers simultaneously in the visual system under different conditions. Spatial light modulation 2-P optogenetics and patch-clamp electrophysiology to study inter-neuronal connectivity strength. Student will be trained by working closely with a postdoctoral fellow. Depending on progress they can develop their own project. Some familiarity with 2-photon imaging and electrophysiology methods is desirable but not absolutely necessary. For remote positions it is necessary to have adequate computational expertise.

Available: 02/18/22, Expires: 03/01/24

Use functional magnetic resonance imaging population receptive field analysis to study visual cortex plasticity during visual-motion-perception rehabilitation in patients with dense cortical visual field scotomas. Patients undergo visual motion rehabiliation training, resulting in improved visual motion perception, often returning motion perception thresholds to normal inside a patient's scotoma. The student will be paired with a more senior member of the laboratory and will be trained on how to perform and analyze functional magnetic resonance imaging data to study the mechanism of recovery.

Available: 02/18/22, Expires: 03/01/24

Study how cortical neurons engage into abnormal (epileptiform) patterns of activity recorded in the electroencephalogram (EEG). We use 2 mouse models of epilepsy: 1) focal cortical seizures are induced acutely by 4-AP injection and 2-photon imaging and optogenetic methods are used to study how different types of neurons contribute to the evolution of epileptiform activity. 2) Cortical circuit changes that occur during the process of epileptogenesis are studied using the kainic acid model of temporal lobe epilepsy. The student will be paired with a senior postdoctoral fellow to learn how to perform and analyze 2-photon imaging experiments and EEG recordings in animals with epilepsy. Depending on progress and independent project could be arranged.Experience with mouse surgeries and 2-photon imaging is desirable but not necessary. For the remote option, significant facility with computational analysis methods is important.

Available: 02/18/22, Expires: 03/01/24

Use statistical methods as well as machine learning approaches like natural language processing and decision tree analysis to analyze data from a cohort of patients with stroke from the Partners System (MGH and BWH). The goal is to improve prediction accuracy for the risk of malignant edema, the etiology of stroke and the risk for recurrent stroke. Students will work closely with a more senior member of the team to learn how to curate appropriately a stroke-patient data base, how to do basic statistical analysis of clinical data, and how to apply natural language processing, image processing and decision tree analysis to clinical problems.

Available: 04/05/22, Expires: 06/01/23

Mouse: Using 2-photon imaging, electrophysiology and high-throughput in situ mRNA hybridization (MERFISH; with J Moffitt) to study: 1. Cortical circuit mechanisms of focal seizure spread and epileptogenesis. 2. Cell-specific functional and transcriptomic abnormalities induced by amyloid deposition. 3. Dense analysis of cortical circuit dysfunction in the MECP2-duplication model of autism. 4. Circuit mechanisms of bi-stable perception Human: 1. Applying decision tree optimization methods (with D Bertsimas) to study how to improve neurological outcomes in stroke 2. Applying fMRI methods to study whether/how visual rehabilitation promotes cortical reorganization after lesions of the visual pathways


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS113890 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2021 - Dec 31, 2025
    NIH
    Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism
    Role: Principal Investigator
  2. I01BX005221 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2021 - Dec 31, 2024
    NIH
    CMA: Network plasticity in acquired epileptogenesis
    Role: Principal Investigator
  3. R21NS120170 (SMIRNAKIS, STELIOS MANOLIS) Sep 15, 2020 - May 31, 2022
    NIH
    Cell-specific in situ functional and transcriptomic dissection of molecular mechanisms of Alzheimer's disease
    Role: Principal Investigator
  4. I01RX002981 (SMIRNAKIS, STELIOS MANOLIS) Feb 1, 2020 - Jan 31, 2024
    NIH
    Developing a rational strategy for visual rehabilitation after cortical lesions
    Role: Principal Investigator
  5. I01BX004729 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2020 - Dec 31, 2023
    NIH
    PROBING THE CELL-SPECIFIC CONTROL OF FOCAL CORTICAL SEIZURE EVENTS IN VIVO
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ash RT, Palagina G, Fernandez-Leon JA, Park J, Seilheimer R, Lee S, Sabharwal J, Reyes F, Wang J, Lu D, Sarfraz M, Froudarakis E, Tolias AS, Wu SM, Smirnakis SM. Increased Reliability of Visually-Evoked Activity in Area V1 of the MECP2-Duplication Mouse Model of Autism. J Neurosci. 2022 08 17; 42(33):6469-6482. PMID: 35831173; PMCID: PMC9398540.
    Citations:    Fields:    
  2. Bhere D, Choi SH, van de Donk P, Hope D, Gortzak K, Kunnummal A, Khalsa J, Revai Lechtich E, Reinshagen C, Leon V, Nissar N, Bi WL, Feng C, Li H, Zhang YS, Liang SH, Vasdev N, Essayed W, Quevedo PV, Golby A, Banouni N, Palagina A, Abdi R, Fury B, Smirnakis S, Lowe A, Reeve B, Hiller A, Chiocca EA, Prestwich G, Wakimoto H, Bauer G, Shah K. Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells. Nat Commun. 2022 05 19; 13(1):2810. PMID: 35589724; PMCID: PMC9120173.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Chan WP, Prescott BR, Barra ME, Chung DY, Kim IS, Saglam H, Hutch MR, Shin M, Zafar SF, Benjamin EJ, Smirnakis SM, Dupuis J, Greer DM, Ong CJ. Dexmedetomidine and Other Analgosedatives Alter Pupil Characteristics in Critically Ill Patients. Crit Care Explor. 2022 May; 4(5):e0691. PMID: 35783547; PMCID: PMC9243241.
    Citations:    
  4. Miller MI, Orfanoudaki A, Cronin M, Saglam H, So Yeon Kim I, Balogun O, Tzalidi M, Vasilopoulos K, Fanaropoulou G, Fanaropoulou NM, Kalin J, Hutch M, Prescott BR, Brush B, Benjamin EJ, Shin M, Mian A, Greer DM, Smirnakis SM, Ong CJ. Natural Language Processing of Radiology Reports to Detect Complications of Ischemic Stroke. Neurocrit Care. 2022 08; 37(Suppl 2):291-302. PMID: 35534660.
    Citations: 1     Fields:    
  5. Rina A, Papanikolaou A, Zong X, Papageorgiou DT, Keliris GA, Smirnakis SM. Visual Motion Coherence Responses in Human Visual Cortex. Front Neurosci. 2022; 16:719250. PMID: 35310109; PMCID: PMC8924467.
    Citations:    
  6. Prescott BR, Saglam H, Duskin JA, Miller MI, Thakur AS, Gholap EA, Hutch MR, Smirnakis SM, Zafar SF, Dupuis J, Benjamin EJ, Greer DM, Ong CJ. Anisocoria and Poor Pupil Reactivity by Quantitative Pupillometry in Patients With Intracranial Pathology. Crit Care Med. 2022 02 01; 50(2):e143-e153. PMID: 34637415; PMCID: PMC8810747.
    Citations: 1     Fields:    Translation:Humans
  7. Keliris GA, Shao Y, Schmid MC, Augath M, Logothetis NK, Smirnakis SM. Macaque Area V2/V3 Reorganization Following Homonymous Retinal Lesions. Front Neurosci. 2022; 16:757091. PMID: 35153666; PMCID: PMC8832035.
    Citations:    
  8. Yue Y, Xu P, Liu Z, Sun X, Su J, Du H, Chen L, Ash RT, Smirnakis S, Simha R, Kusner L, Zeng C, Lu H. Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit. Sci Adv. 2021 Oct 22; 7(43):eabf7467. PMID: 34678068; PMCID: PMC8535852.
    Citations: 1     Fields:    
  9. Tehovnik EJ, Froudarakis E, Scala F, Smirnakis SM, Patel SS, Tolias AS. Visuomotor control in mice and primates. Neurosci Biobehav Rev. 2021 11; 130:185-200. PMID: 34416241.
    Citations:    Fields:    Translation:AnimalsCells
  10. Ash RT, Buffington SA, Park J, Suter B, Costa-Mattioli M, Zoghbi HY, Smirnakis SM. Inhibition of Elevated Ras-MAPK Signaling Normalizes Enhanced Motor Learning and Excessive Clustered Dendritic Spine Stabilization in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro. 2021 Jul-Aug; 8(4). PMID: 34021030; PMCID: PMC8260274.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Sreekrishnan A, Ong CJ, Mahajan R, Prescott B, Smirnakis SM, Bevers MB, Feske SK, Snider SB. Subcortical Sparing Associated with Ambulatory Independence after Hemicraniectomy for Malignant Infarction. J Stroke Cerebrovasc Dis. 2021 Aug; 30(8):105850. PMID: 34000606.
    Citations:    Fields:    Translation:Humans
  12. Ash RT, Park J, Suter B, Zoghbi HY, Smirnakis SM. Excessive Formation and Stabilization of Dendritic Spine Clusters in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro. 2021 Jan-Feb; 8(1). PMID: 33168618; PMCID: PMC7877475.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Smyrnakis I, Papadopouli M, Pallagina G, Smirnakis S. Information Capacity of a Stochastically Responding Neuron Assembly. Neurocomputing. 2021 May 14; 436:22-34. PMID: 34539080; PMCID: PMC8443124.
    Citations:    
  14. Sun ZE, Smirnakis S, Feske S. Blood Pressure Thresholds During Endovascular Therapy in Ischemic Stroke. JAMA Neurol. 2020 12 01; 77(12):1578-1579. PMID: 33044516.
    Citations:    Fields:    Translation:Humans
  15. Izzy S, Tahir Z, Cote DJ, Al Jarrah A, Roberts MB, Turbett S, Kadar A, Smirnakis SM, Feske SK, Zafonte R, Fishman JA, El Khoury J. Characteristics and Outcomes of Latinx Patients With COVID-19 in Comparison With Other Ethnic and Racial Groups. Open Forum Infect Dis. 2020 Oct; 7(10):ofaa401. PMID: 33088846; PMCID: PMC7499713.
    Citations: 14     
  16. Ong CJ, Orfanoudaki A, Zhang R, Caprasse FPM, Hutch M, Ma L, Fard D, Balogun O, Miller MI, Minnig M, Saglam H, Prescott B, Greer DM, Smirnakis S, Bertsimas D. Machine learning and natural language processing methods to identify ischemic stroke, acuity and location from radiology reports. PLoS One. 2020; 15(6):e0234908. PMID: 32559211.
    Citations: 14     Fields:    Translation:Humans
  17. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Correction to: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 Feb; 26(1):121. PMID: 31515701.
    Citations:    Fields:    
  18. Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM. Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons. Nat Commun. 2019 11 26; 10(1):5372. PMID: 31772192.
    Citations: 14     Fields:    Translation:AnimalsCells
  19. Froudarakis E, Fahey PG, Reimer J, Smirnakis SM, Tehovnik EJ, Tolias AS. The Visual Cortex in Context. Annu Rev Vis Sci. 2019 09 15; 5:317-339. PMID: 31525143.
    Citations: 12     Fields:    Translation:HumansAnimals
  20. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 02; 26(1):118-120. PMID: 31286440.
    Citations:    Fields:    Translation:Humans
  21. Palagina G, Meyer JF, Smirnakis SM. Inhibitory Units: An Organizing Nidus for Feature-Selective SubNetworks in Area V1. J Neurosci. 2019 06 19; 39(25):4931-4944. PMID: 30979814; PMCID: PMC6670246.
    Citations: 2     Fields:    Translation:AnimalsCells
  22. Ong C, Hutch M, Barra M, Kim A, Zafar S, Smirnakis S. Effects of Osmotic Therapy on Pupil Reactivity: Quantification Using Pupillometry in Critically Ill Neurologic Patients. Neurocrit Care. 2019 04; 30(2):307-315. PMID: 30298336.
    Citations: 10     Fields:    Translation:Humans
  23. Ong C, Hutch M, Smirnakis S. The Effect of Ambient Light Conditions on Quantitative Pupillometry. Neurocrit Care. 2019 04; 30(2):316-321. PMID: 30218349.
    Citations: 11     Fields:    Translation:Humans
  24. Keliris GA, Li Q, Papanikolaou A, Logothetis NK, Smirnakis SM. Estimating average single-neuron visual receptive field sizes by fMRI. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6425-6434. PMID: 30867291; PMCID: PMC6442598.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  25. Lee S, Park J, Smirnakis SM. Internal Gain Modulations, But Not Changes in Stimulus Contrast, Preserve the Neural Code. J Neurosci. 2019 02 27; 39(9):1671-1687. PMID: 30647148; PMCID: PMC6391566.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Ash RT, Fahey PG, Park J, Zoghbi HY, Smirnakis SM. Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome. eNeuro. 2018 May-Jun; 5(3). PMID: 30105297.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Solomon IH, Spera KM, Ryan SL, Helgager J, Andrici J, Zaki SR, Vaitkevicius H, Leon KE, Wilson MR, DeRisi JL, Koo S, Smirnakis SM, De Girolami U. Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. JAMA Neurol. 2018 06 01; 75(6):746-750. PMID: 29554185; PMCID: PMC5885183.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  28. Meyer J, Maheshwari A, Noebels J, Smirnakis S. Asynchronous suppression of visual cortex during absence seizures in stargazer mice. Nat Commun. 2018 05 16; 9(1):1938. PMID: 29769525.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  29. Meyer JF, Golshani P, Smirnakis SM. The Effect of Single Pyramidal Neuron Firing Within Layer 2/3 and Layer 4 in Mouse V1. Front Neural Circuits. 2018; 12:29. PMID: 29713266.
    Citations:    Fields:    Translation:AnimalsCells
  30. Papanikolaou A, Keliris GA, Papageorgiou TD, Schiefer U, Logothetis NK, Smirnakis SM. Organization of area hV5/MT+ in subjects with homonymous visual field defects. Neuroimage. 2019 04 15; 190:254-268. PMID: 29627591.
    Citations: 6     Fields:    Translation:Humans
  31. Troullinou E, Tsagkatakis G, Palagina G, Papadopouli M, Smirnakis SM, Tsakalides P. Dictionary Learning for Spontaneous Neural Activity Modeling. Proc Eur Signal Process Conf EUSIPCO. 2017 Aug-Sep; 2017:1579-1583. PMID: 32923380; PMCID: PMC7485749.
    Citations:    
  32. Smyrnakis I, Andreadakis V, Selimis V, Kalaitzakis M, Bachourou T, Kaloutsakis G, Kymionis GD, Smirnakis S, Aslanides IM. RADAR: A novel fast-screening method for reading difficulties with special focus on dyslexia. PLoS One. 2017; 12(8):e0182597. PMID: 28800632.
    Citations: 2     Fields:    Translation:Humans
  33. Lee S, Meyer JF, Park J, Smirnakis SM. Visually Driven Neuropil Activity and Information Encoding in Mouse Primary Visual Cortex. Front Neural Circuits. 2017; 11:50. PMID: 28785207.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Palagina G, Meyer JF, Smirnakis SM. Complex Visual Motion Representation in Mouse Area V1. J Neurosci. 2017 01 04; 37(1):164-183. PMID: 28053039; PMCID: PMC5214628.
    Citations: 20     Fields:    Translation:AnimalsCells
  35. Smirnakis SM. Probing Human Visual Deficits with Functional Magnetic Resonance Imaging. Annu Rev Vis Sci. 2016 10 14; 2:171-195. PMID: 28532356.
    Citations: 4     Fields:    Translation:Humans
  36. Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY. Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model. Neuron. 2016 Aug 17; 91(4):739-747. PMID: 27499081; PMCID: PMC5019177.
    Citations: 48     Fields:    Translation:AnimalsCells
  37. Papanikolaou A, Keliris GA, Lee S, Logothetis NK, Smirnakis SM. Nonlinear population receptive field changes in human area V5/MT+ of healthy subjects with simulated visual field scotomas. Neuroimage. 2015 Oct 15; 120:176-90. PMID: 26146195.
    Citations: 6     Fields:    Translation:Humans
  38. Olson DM, Andrew Kofke W, O'Phelan K, Gupta PK, Figueroa SA, Smirnakis SM, Leroux PD, Suarez JI. Global monitoring in the neurocritical care unit. Neurocrit Care. 2015 Jun; 22(3):337-47. PMID: 25846709.
    Citations: 1     Fields:    Translation:Humans
  39. Bershad EM, Rao CP, Vuong KD, Mazabob J, Brown G, Styron SL, Nguyen T, Delledera E, Smirnakis SM, Lazaridis C, Georgiadis AL, Mokracek M, Seipel TJ, Nisbet JJ, Baskaran V, Chang AH, Stewart P, Suarez JI. Multidisciplinary protocol for rapid head computed tomography turnaround time in acute stroke patients. J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1256-61. PMID: 25920753.
    Citations: 2     Fields:    Translation:Humans
  40. Lee S, Papanikolaou A, Keliris GA, Smirnakis SM. Topographical estimation of visual population receptive fields by FMRI. J Vis Exp. 2015 Feb 03; (96). PMID: 25741774.
    Citations: 2     Fields:    Translation:HumansCells
  41. Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15. PMID: 24960694.
    Citations: 41     Fields:    Translation:AnimalsCells
  42. Papanikolaou A, Keliris GA, Papageorgiou TD, Shao Y, Krapp E, Papageorgiou E, Stingl K, Bruckmann A, Schiefer U, Logothetis NK, Smirnakis SM. Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1656-65. PMID: 24706881.
    Citations: 31     Fields:    Translation:Humans
  43. Ecker AS, Berens P, Cotton RJ, Subramaniyan M, Denfield GH, Cadwell CR, Smirnakis SM, Bethge M, Tolias AS. State dependence of noise correlations in macaque primary visual cortex. Neuron. 2014 Apr 02; 82(1):235-48. PMID: 24698278.
    Citations: 163     Fields:    Translation:AnimalsCells
  44. Jiang M, Ash RT, Baker SA, Suter B, Ferguson A, Park J, Rudy J, Torsky SP, Chao HT, Zoghbi HY, Smirnakis SM. Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome. J Neurosci. 2013 Dec 11; 33(50):19518-33. PMID: 24336718.
    Citations: 67     Fields:    Translation:AnimalsCells
  45. Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jägle H, Logothetis NK, Smirnakis SM. Visual cortex organisation in a macaque monkey with macular degeneration. Eur J Neurosci. 2013 Nov; 38(10):3456-64. PMID: 24033706; PMCID: PMC3834013.
    Citations: 11     Fields:    Translation:Animals
  46. Lee S, Papanikolaou A, Logothetis NK, Smirnakis SM, Keliris GA. A new method for estimating population receptive field topography in visual cortex. Neuroimage. 2013 Nov 01; 81:144-157. PMID: 23684878.
    Citations: 27     Fields:    Translation:Humans
  47. Smyrnakis I, Smirnakis S. Information transfer through stochastic transmission of a linear combination of rates. Neural Comput. 2013 Sep; 25(9):2265-302. PMID: 23663145.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  48. Hannawi Y, Smirnakis SM. Emerging subspecialties: neuroinformatics. Neurology. 2013 Apr 09; 80(15):e166-8. PMID: 23569003; PMCID: PMC3662267.
    Citations: 2     Fields:    Translation:Humans
  49. Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL. Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. Eur J Neurosci. 2013 Apr; 37(8):1203-20. PMID: 23347239.
    Citations: 67     Fields:    Translation:AnimalsCells
  50. Dominik Fischer M, Zobor D, Keliris GA, Shao Y, Seeliger MW, Haverkamp S, Jägle H, Logothetis NK, Smirnakis SM. Detailed functional and structural characterization of a macular lesion in a rhesus macaque. Doc Ophthalmol. 2012 Dec; 125(3):179-94. PMID: 22923360.
    Citations: 7     Fields:    Translation:AnimalsCells
  51. Suarez JI, Geocadin R, Hall C, Le Roux PD, Smirnakis S, Wijman CA, Zaidat OO. The neurocritical care research network: NCRN. Neurocrit Care. 2012 Feb; 16(1):29-34. PMID: 21792751.
    Citations: 5     Fields:    Translation:Humans
  52. Wijman CA, Smirnakis SM, Vespa P, Szigeti K, Ziai WC, Ning MM, Rosand J, Hanley DF, Geocadin R, Hall C, Le Roux PD, Suarez JI, Zaidat OO. Research and technology in neurocritical care. Neurocrit Care. 2012 Feb; 16(1):42-54. PMID: 21796494.
    Citations: 6     Fields:    Translation:Humans
  53. Nichols JA, Nichols AR, Smirnakis SM, Engineer ND, Kilgard MP, Atzori M. Vagus nerve stimulation modulates cortical synchrony and excitability through the activation of muscarinic receptors. Neuroscience. 2011 Aug 25; 189:207-14. PMID: 21627982.
    Citations: 64     Fields:    Translation:AnimalsPHPublic Health
  54. Wandell BA, Smirnakis SM. Plasticity and stability of visual field maps in adult primary visual cortex. Nat Rev Neurosci. 2009 Dec; 10(12):873-84. PMID: 19904279.
    Citations: 99     Fields:    Translation:HumansAnimals
  55. Golshani P, Gonçalves JT, Khoshkhoo S, Mostany R, Smirnakis S, Portera-Cailliau C. Internally mediated developmental desynchronization of neocortical network activity. J Neurosci. 2009 Sep 02; 29(35):10890-9. PMID: 19726647.
    Citations: 124     Fields:    Translation:Animals
  56. Schmid MC, Panagiotaropoulos T, Augath MA, Logothetis NK, Smirnakis SM. Visually driven activation in macaque areas V2 and V3 without input from the primary visual cortex. PLoS One. 2009; 4(5):e5527. PMID: 19436733.
    Citations: 36     Fields:    Translation:AnimalsCells
  57. Tehovnik EJ, Slocum WM, Smirnakis SM, Tolias AS. Microstimulation of visual cortex to restore vision. Prog Brain Res. 2009; 175:347-75. PMID: 19660667.
    Citations: 23     Fields:    Translation:HumansAnimals
  58. Smirnakis SM, Schmid MC, Weber B, Tolias AS, Augath M, Logothetis NK. Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization. J Cereb Blood Flow Metab. 2007 Jun; 27(6):1248-61. PMID: 17213863.
    Citations: 40     Fields:    Translation:Animals
  59. Schmid MC, Oeltermann A, Juchem C, Logothetis NK, Smirnakis SM. Simultaneous EEG and fMRI in the macaque monkey at 4.7 Tesla. Magn Reson Imaging. 2006 May; 24(4):335-42. PMID: 16677938.
    Citations: 8     Fields:    Translation:Animals
  60. Smirnakis SM, Brewer AA, Schmid MC, Tolias AS, Schüz A, Augath M, Inhoffen W, Wandell BA, Logothetis NK. Lack of long-term cortical reorganization after macaque retinal lesions. Nature. 2005 May 19; 435(7040):300-7. PMID: 15902248.
    Citations: 81     Fields:    Translation:Animals
  61. Tolias AS, Keliris GA, Smirnakis SM, Logothetis NK. Neurons in macaque area V4 acquire directional tuning after adaptation to motion stimuli. Nat Neurosci. 2005 May; 8(5):591-3. PMID: 15834417.
    Citations: 51     Fields:    Translation:AnimalsCells
  62. Ning MM, Smirnakis S, Furie KL, Sheen VL. Adult acute disseminated encephalomyelitis associated with poststreptococcal infection. J Clin Neurosci. 2005 Apr; 12(3):298-300. PMID: 15851086.
    Citations: 3     Fields:    Translation:Humans
  63. Tolias AS, Smirnakis SM, Augath MA, Trinath T, Logothetis NK. Motion processing in the macaque: revisited with functional magnetic resonance imaging. J Neurosci. 2001 Nov 01; 21(21):8594-601. PMID: 11606647; PMCID: PMC6762813.
    Citations: 25     Fields:    Translation:Animals
  64. Tolias AS, Moore T, Smirnakis SM, Tehovnik EJ, Siapas AG, Schiller PH. Eye movements modulate visual receptive fields of V4 neurons. Neuron. 2001 Mar; 29(3):757-67. PMID: 11301034.
    Citations: 122     Fields:    Translation:AnimalsCells
  65. Smirnakis SM, Berry MJ, Warland DK, Bialek W, Meister M. Adaptation of retinal processing to image contrast and spatial scale. Nature. 1997 Mar 06; 386(6620):69-73. PMID: 9052781.
    Citations: 170     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.