Harvard Catalyst Profiles

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Stelios Manolis Smirnakis, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS113890 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2021 - Dec 31, 2025
    Dense Analysis of Cortical Circuit Dysfunction in the MECP2-duplication Syndrome of Autism
    Role: Principal Investigator
  2. I01BX005221 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2021 - Dec 31, 2024
    CMA: Network plasticity in acquired epileptogenesis
    Role: Principal Investigator
  3. R21NS120170 (SMIRNAKIS, STELIOS MANOLIS) Sep 15, 2020 - May 31, 2022
    Cell-specific in situ functional and transcriptomic dissection of molecular mechanisms of Alzheimer's disease
    Role: Principal Investigator
  4. I01RX002981 (SMIRNAKIS, STELIOS MANOLIS) Feb 1, 2020 - Jan 31, 2024
    Developing a rational strategy for visual rehabilitation after cortical lesions
    Role: Principal Investigator
  5. I01BX004729 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2020 - Dec 31, 2023
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yue Y, Xu P, Liu Z, Sun X, Su J, Du H, Chen L, Ash RT, Smirnakis S, Simha R, Kusner L, Zeng C, Lu H. Motor training improves coordination and anxiety in symptomatic Mecp2-null mice despite impaired functional connectivity within the motor circuit. Sci Adv. 2021 Oct 22; 7(43):eabf7467. PMID: 34678068.
    Citations:    Fields:    
  2. Prescott BR, Saglam H, Duskin JA, Miller MI, Thakur AS, Gholap EA, Hutch MR, Smirnakis SM, Zafar SF, Dupuis J, Benjamin EJ, Greer DM, Ong CJ. Anisocoria and Poor Pupil Reactivity by Quantitative Pupillometry in Patients With Intracranial Pathology. Crit Care Med. 2021 Sep 22. PMID: 34637415.
    Citations:    Fields:    
  3. Tehovnik EJ, Froudarakis E, Scala F, Smirnakis SM, Patel SS, Tolias AS. Visuomotor control in mice and primates. Neurosci Biobehav Rev. 2021 11; 130:185-200. PMID: 34416241.
    Citations:    Fields:    Translation:AnimalsCells
  4. Ash RT, Buffington SA, Park J, Suter B, Costa-Mattioli M, Zoghbi HY, Smirnakis SM. Inhibition of Elevated Ras-MAPK Signaling Normalizes Enhanced Motor Learning and Excessive Clustered Dendritic Spine Stabilization in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro. 2021 Jul-Aug; 8(4). PMID: 34021030.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Sreekrishnan A, Ong CJ, Mahajan R, Prescott B, Smirnakis SM, Bevers MB, Feske SK, Snider SB. Subcortical Sparing Associated with Ambulatory Independence after Hemicraniectomy for Malignant Infarction. J Stroke Cerebrovasc Dis. 2021 Aug; 30(8):105850. PMID: 34000606.
    Citations:    Fields:    Translation:Humans
  6. Ash RT, Park J, Suter B, Zoghbi HY, Smirnakis SM. Excessive Formation and Stabilization of Dendritic Spine Clusters in the MECP2-Duplication Syndrome Mouse Model of Autism. eNeuro. 2021 Jan-Feb; 8(1). PMID: 33168618.
    Citations: 2     Fields:    Translation:AnimalsCells
  7. Smyrnakis I, Papadopouli M, Pallagina G, Smirnakis S. Information Capacity of a Stochastically Responding Neuron Assembly. Neurocomputing. 2021 May 14; 436:22-34. PMID: 34539080.
  8. Sun ZE, Smirnakis S, Feske S. Blood Pressure Thresholds During Endovascular Therapy in Ischemic Stroke. JAMA Neurol. 2020 12 01; 77(12):1578-1579. PMID: 33044516.
    Citations:    Fields:    Translation:Humans
  9. Izzy S, Tahir Z, Cote DJ, Al Jarrah A, Roberts MB, Turbett S, Kadar A, Smirnakis SM, Feske SK, Zafonte R, Fishman JA, El Khoury J. Characteristics and Outcomes of Latinx Patients With COVID-19 in Comparison With Other Ethnic and Racial Groups. Open Forum Infect Dis. 2020 Oct; 7(10):ofaa401. PMID: 33088846.
    Citations: 9     
  10. Ong CJ, Orfanoudaki A, Zhang R, Caprasse FPM, Hutch M, Ma L, Fard D, Balogun O, Miller MI, Minnig M, Saglam H, Prescott B, Greer DM, Smirnakis S, Bertsimas D. Machine learning and natural language processing methods to identify ischemic stroke, acuity and location from radiology reports. PLoS One. 2020; 15(6):e0234908. PMID: 32559211.
    Citations: 9     Fields:    Translation:Humans
  11. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Correction to: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 Feb; 26(1):121. PMID: 31515701.
    Citations:    Fields:    
  12. Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM. Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons. Nat Commun. 2019 11 26; 10(1):5372. PMID: 31772192.
    Citations: 8     Fields:    Translation:AnimalsCells
  13. Froudarakis E, Fahey PG, Reimer J, Smirnakis SM, Tehovnik EJ, Tolias AS. The Visual Cortex in Context. Annu Rev Vis Sci. 2019 09 15; 5:317-339. PMID: 31525143.
    Citations: 9     Fields:    Translation:HumansAnimals
  14. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 02; 26(1):118-120. PMID: 31286440.
    Citations:    Fields:    Translation:Humans
  15. Palagina G, Meyer JF, Smirnakis SM. Inhibitory Units: An Organizing Nidus for Feature-Selective SubNetworks in Area V1. J Neurosci. 2019 06 19; 39(25):4931-4944. PMID: 30979814.
    Citations: 2     Fields:    Translation:AnimalsCells
  16. Ong C, Hutch M, Smirnakis S. The Effect of Ambient Light Conditions on Quantitative Pupillometry. Neurocrit Care. 2019 04; 30(2):316-321. PMID: 30218349.
    Citations: 4     Fields:    Translation:Humans
  17. Ong C, Hutch M, Barra M, Kim A, Zafar S, Smirnakis S. Effects of Osmotic Therapy on Pupil Reactivity: Quantification Using Pupillometry in Critically Ill Neurologic Patients. Neurocrit Care. 2019 04; 30(2):307-315. PMID: 30298336.
    Citations: 8     Fields:    Translation:Humans
  18. Keliris GA, Li Q, Papanikolaou A, Logothetis NK, Smirnakis SM. Estimating average single-neuron visual receptive field sizes by fMRI. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6425-6434. PMID: 30867291.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  19. Lee S, Park J, Smirnakis SM. Internal Gain Modulations, But Not Changes in Stimulus Contrast, Preserve the Neural Code. J Neurosci. 2019 02 27; 39(9):1671-1687. PMID: 30647148.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Ash RT, Fahey PG, Park J, Zoghbi HY, Smirnakis SM. Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome. eNeuro. 2018 May-Jun; 5(3). PMID: 30105297.
    Citations: 5     Fields:    Translation:AnimalsCells
  21. Solomon IH, Spera KM, Ryan SL, Helgager J, Andrici J, Zaki SR, Vaitkevicius H, Leon KE, Wilson MR, DeRisi JL, Koo S, Smirnakis SM, De Girolami U. Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. JAMA Neurol. 2018 06 01; 75(6):746-750. PMID: 29554185.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. Meyer J, Maheshwari A, Noebels J, Smirnakis S. Asynchronous suppression of visual cortex during absence seizures in stargazer mice. Nat Commun. 2018 05 16; 9(1):1938. PMID: 29769525.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Meyer JF, Golshani P, Smirnakis SM. The Effect of Single Pyramidal Neuron Firing Within Layer 2/3 and Layer 4 in Mouse V1. Front Neural Circuits. 2018; 12:29. PMID: 29713266.
    Citations:    Fields:    Translation:AnimalsCells
  24. Papanikolaou A, Keliris GA, Papageorgiou TD, Schiefer U, Logothetis NK, Smirnakis SM. Organization of area hV5/MT+ in subjects with homonymous visual field defects. Neuroimage. 2019 04 15; 190:254-268. PMID: 29627591.
    Citations: 5     Fields:    Translation:Humans
  25. Troullinou E, Tsagkatakis G, Palagina G, Papadopouli M, Smirnakis SM, Tsakalides P. Dictionary Learning for Spontaneous Neural Activity Modeling. Proc Eur Signal Process Conf EUSIPCO. 2017 Aug-Sep; 2017:1579-1583. PMID: 32923380.
  26. Smyrnakis I, Andreadakis V, Selimis V, Kalaitzakis M, Bachourou T, Kaloutsakis G, Kymionis GD, Smirnakis S, Aslanides IM. RADAR: A novel fast-screening method for reading difficulties with special focus on dyslexia. PLoS One. 2017; 12(8):e0182597. PMID: 28800632.
    Citations: 2     Fields:    Translation:Humans
  27. Lee S, Meyer JF, Park J, Smirnakis SM. Visually Driven Neuropil Activity and Information Encoding in Mouse Primary Visual Cortex. Front Neural Circuits. 2017; 11:50. PMID: 28785207.
    Citations: 7     Fields:    Translation:AnimalsCells
  28. Palagina G, Meyer JF, Smirnakis SM. Complex Visual Motion Representation in Mouse Area V1. J Neurosci. 2017 01 04; 37(1):164-183. PMID: 28053039.
    Citations: 16     Fields:    Translation:AnimalsCells
  29. Smirnakis SM. Probing Human Visual Deficits with Functional Magnetic Resonance Imaging. Annu Rev Vis Sci. 2016 10 14; 2:171-195. PMID: 28532356.
    Citations: 3     Fields:    Translation:Humans
  30. Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY. Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model. Neuron. 2016 Aug 17; 91(4):739-747. PMID: 27499081.
    Citations: 38     Fields:    Translation:AnimalsCells
  31. Papanikolaou A, Keliris GA, Lee S, Logothetis NK, Smirnakis SM. Nonlinear population receptive field changes in human area V5/MT+ of healthy subjects with simulated visual field scotomas. Neuroimage. 2015 Oct 15; 120:176-90. PMID: 26146195.
    Citations: 6     Fields:    Translation:Humans
  32. Olson DM, Andrew Kofke W, O'Phelan K, Gupta PK, Figueroa SA, Smirnakis SM, Leroux PD, Suarez JI. Global monitoring in the neurocritical care unit. Neurocrit Care. 2015 Jun; 22(3):337-47. PMID: 25846709.
    Citations:    Fields:    Translation:Humans
  33. Bershad EM, Rao CP, Vuong KD, Mazabob J, Brown G, Styron SL, Nguyen T, Delledera E, Smirnakis SM, Lazaridis C, Georgiadis AL, Mokracek M, Seipel TJ, Nisbet JJ, Baskaran V, Chang AH, Stewart P, Suarez JI. Multidisciplinary protocol for rapid head computed tomography turnaround time in acute stroke patients. J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1256-61. PMID: 25920753.
    Citations: 1     Fields:    Translation:Humans
  34. Lee S, Papanikolaou A, Keliris GA, Smirnakis SM. Topographical estimation of visual population receptive fields by FMRI. J Vis Exp. 2015 Feb 03; (96). PMID: 25741774.
    Citations: 2     Fields:    Translation:HumansCells
  35. Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15. PMID: 24960694.
    Citations: 34     Fields:    Translation:AnimalsCells
  36. Papanikolaou A, Keliris GA, Papageorgiou TD, Shao Y, Krapp E, Papageorgiou E, Stingl K, Bruckmann A, Schiefer U, Logothetis NK, Smirnakis SM. Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1656-65. PMID: 24706881.
    Citations: 21     Fields:    Translation:Humans
  37. Ecker AS, Berens P, Cotton RJ, Subramaniyan M, Denfield GH, Cadwell CR, Smirnakis SM, Bethge M, Tolias AS. State dependence of noise correlations in macaque primary visual cortex. Neuron. 2014 Apr 02; 82(1):235-48. PMID: 24698278.
    Citations: 137     Fields:    Translation:AnimalsCells
  38. Jiang M, Ash RT, Baker SA, Suter B, Ferguson A, Park J, Rudy J, Torsky SP, Chao HT, Zoghbi HY, Smirnakis SM. Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome. J Neurosci. 2013 Dec 11; 33(50):19518-33. PMID: 24336718.
    Citations: 58     Fields:    Translation:AnimalsCells
  39. Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jägle H, Logothetis NK, Smirnakis SM. Visual cortex organisation in a macaque monkey with macular degeneration. Eur J Neurosci. 2013 Nov; 38(10):3456-64. PMID: 24033706.
    Citations: 5     Fields:    Translation:Animals
  40. Lee S, Papanikolaou A, Logothetis NK, Smirnakis SM, Keliris GA. A new method for estimating population receptive field topography in visual cortex. Neuroimage. 2013 Nov 01; 81:144-157. PMID: 23684878.
    Citations: 21     Fields:    Translation:Humans
  41. Smyrnakis I, Smirnakis S. Information transfer through stochastic transmission of a linear combination of rates. Neural Comput. 2013 Sep; 25(9):2265-302. PMID: 23663145.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  42. Hannawi Y, Smirnakis SM. Emerging subspecialties: neuroinformatics. Neurology. 2013 Apr 09; 80(15):e166-8. PMID: 23569003.
    Citations: 2     Fields:    Translation:Humans
  43. Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL. Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. Eur J Neurosci. 2013 Apr; 37(8):1203-20. PMID: 23347239.
    Citations: 57     Fields:    Translation:AnimalsCells
  44. Dominik Fischer M, Zobor D, Keliris GA, Shao Y, Seeliger MW, Haverkamp S, Jägle H, Logothetis NK, Smirnakis SM. Detailed functional and structural characterization of a macular lesion in a rhesus macaque. Doc Ophthalmol. 2012 Dec; 125(3):179-94. PMID: 22923360.
    Citations: 5     Fields:    Translation:AnimalsCells
  45. Suarez JI, Geocadin R, Hall C, Le Roux PD, Smirnakis S, Wijman CA, Zaidat OO. The neurocritical care research network: NCRN. Neurocrit Care. 2012 Feb; 16(1):29-34. PMID: 21792751.
    Citations: 6     Fields:    Translation:Humans
  46. Wijman CA, Smirnakis SM, Vespa P, Szigeti K, Ziai WC, Ning MM, Rosand J, Hanley DF, Geocadin R, Hall C, Le Roux PD, Suarez JI, Zaidat OO. Research and technology in neurocritical care. Neurocrit Care. 2012 Feb; 16(1):42-54. PMID: 21796494.
    Citations: 6     Fields:    Translation:Humans
  47. Nichols JA, Nichols AR, Smirnakis SM, Engineer ND, Kilgard MP, Atzori M. Vagus nerve stimulation modulates cortical synchrony and excitability through the activation of muscarinic receptors. Neuroscience. 2011 Aug 25; 189:207-14. PMID: 21627982.
    Citations: 48     Fields:    Translation:AnimalsPHPublic Health
  48. Wandell BA, Smirnakis SM. Plasticity and stability of visual field maps in adult primary visual cortex. Nat Rev Neurosci. 2009 Dec; 10(12):873-84. PMID: 19904279.
    Citations: 88     Fields:    Translation:HumansAnimals
  49. Golshani P, Gonçalves JT, Khoshkhoo S, Mostany R, Smirnakis S, Portera-Cailliau C. Internally mediated developmental desynchronization of neocortical network activity. J Neurosci. 2009 Sep 02; 29(35):10890-9. PMID: 19726647.
    Citations: 113     Fields:    Translation:Animals
  50. Schmid MC, Panagiotaropoulos T, Augath MA, Logothetis NK, Smirnakis SM. Visually driven activation in macaque areas V2 and V3 without input from the primary visual cortex. PLoS One. 2009; 4(5):e5527. PMID: 19436733.
    Citations: 32     Fields:    Translation:AnimalsCells
  51. Tehovnik EJ, Slocum WM, Smirnakis SM, Tolias AS. Microstimulation of visual cortex to restore vision. Prog Brain Res. 2009; 175:347-75. PMID: 19660667.
    Citations: 18     Fields:    Translation:HumansAnimals
  52. Smirnakis SM, Schmid MC, Weber B, Tolias AS, Augath M, Logothetis NK. Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization. J Cereb Blood Flow Metab. 2007 Jun; 27(6):1248-61. PMID: 17213863.
    Citations: 38     Fields:    Translation:Animals
  53. Schmid MC, Oeltermann A, Juchem C, Logothetis NK, Smirnakis SM. Simultaneous EEG and fMRI in the macaque monkey at 4.7 Tesla. Magn Reson Imaging. 2006 May; 24(4):335-42. PMID: 16677938.
    Citations: 6     Fields:    Translation:Animals
  54. Smirnakis SM, Brewer AA, Schmid MC, Tolias AS, Schüz A, Augath M, Inhoffen W, Wandell BA, Logothetis NK. Lack of long-term cortical reorganization after macaque retinal lesions. Nature. 2005 May 19; 435(7040):300-7. PMID: 15902248.
    Citations: 75     Fields:    Translation:Animals
  55. Tolias AS, Keliris GA, Smirnakis SM, Logothetis NK. Neurons in macaque area V4 acquire directional tuning after adaptation to motion stimuli. Nat Neurosci. 2005 May; 8(5):591-3. PMID: 15834417.
    Citations: 51     Fields:    Translation:AnimalsCells
  56. Ning MM, Smirnakis S, Furie KL, Sheen VL. Adult acute disseminated encephalomyelitis associated with poststreptococcal infection. J Clin Neurosci. 2005 Apr; 12(3):298-300. PMID: 15851086.
    Citations: 3     Fields:    Translation:Humans
  57. Tolias AS, Smirnakis SM, Augath MA, Trinath T, Logothetis NK. Motion processing in the macaque: revisited with functional magnetic resonance imaging. J Neurosci. 2001 Nov 01; 21(21):8594-601. PMID: 11606647.
    Citations: 19     Fields:    Translation:Animals
  58. Tolias AS, Moore T, Smirnakis SM, Tehovnik EJ, Siapas AG, Schiller PH. Eye movements modulate visual receptive fields of V4 neurons. Neuron. 2001 Mar; 29(3):757-67. PMID: 11301034.
    Citations: 113     Fields:    Translation:AnimalsCells
  59. Smirnakis SM, Berry MJ, Warland DK, Bialek W, Meister M. Adaptation of retinal processing to image contrast and spatial scale. Nature. 1997 Mar 06; 386(6620):69-73. PMID: 9052781.
    Citations: 140     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.