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Stelios Manolis Smirnakis, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. I01RX002981 (SMIRNAKIS, STELIOS MANOLIS) Feb 1, 2020 - Jan 31, 2024
    Developing a rational strategy for visual rehabilitation after cortical lesions
    Role: Principal Investigator
  2. I01BX004729 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2020 - Dec 31, 2023
    Role: Principal Investigator
  3. R21NS096640 (SMIRNAKIS, STELIOS MANOLIS) Sep 30, 2016 - Sep 29, 2018
    M1 circuit dysfunction in MECP2 duplication syndrome
    Role: Principal Investigator
  4. R21NS088457 (NOEBELS, JEFFREY) May 1, 2015 - Apr 30, 2017
    In vivo recruitment of neocortical neurons in stargazer absence seizures
    Role: Co-Principal Investigator
  5. R01EY024019 (SMIRNAKIS, STELIOS MANOLIS) Jan 1, 2014 - Mar 31, 2018
    Population receptive field analysis in subjects with area V1+ lesions.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ong CJ, Orfanoudaki A, Zhang R, Caprasse FPM, Hutch M, Ma L, Fard D, Balogun O, Miller MI, Minnig M, Saglam H, Prescott B, Greer DM, Smirnakis S, Bertsimas D. Machine learning and natural language processing methods to identify ischemic stroke, acuity and location from radiology reports. PLoS One. 2020; 15(6):e0234908. PMID: 32559211.
  2. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Correction to: Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 Feb; 26(1):121. PMID: 31515701.
  3. Park J, Papoutsi A, Ash RT, Marin MA, Poirazi P, Smirnakis SM. Contribution of apical and basal dendrites to orientation encoding in mouse V1 L2/3 pyramidal neurons. Nat Commun. 2019 11 26; 10(1):5372. PMID: 31772192.
  4. Froudarakis E, Fahey PG, Reimer J, Smirnakis SM, Tehovnik EJ, Tolias AS. The Visual Cortex in Context. Annu Rev Vis Sci. 2019 09 15; 5:317-339. PMID: 31525143.
  5. Singhal T, Solomon I, Akbik F, Smirnakis S, Vaitkevicius H. Ventral striatal and septal area hypermetabolism on FDG-PET in herpes simplex viral encephalitis. J Neurovirol. 2020 02; 26(1):118-120. PMID: 31286440.
  6. Palagina G, Meyer JF, Smirnakis SM. Inhibitory Units: An Organizing Nidus for Feature-Selective SubNetworks in Area V1. J Neurosci. 2019 06 19; 39(25):4931-4944. PMID: 30979814.
  7. Ong C, Hutch M, Smirnakis S. The Effect of Ambient Light Conditions on Quantitative Pupillometry. Neurocrit Care. 2019 04; 30(2):316-321. PMID: 30218349.
    Citations:    Fields:    
  8. Ong C, Hutch M, Barra M, Kim A, Zafar S, Smirnakis S. Effects of Osmotic Therapy on Pupil Reactivity: Quantification Using Pupillometry in Critically Ill Neurologic Patients. Neurocrit Care. 2019 04; 30(2):307-315. PMID: 30298336.
    Citations:    Fields:    
  9. Keliris GA, Li Q, Papanikolaou A, Logothetis NK, Smirnakis SM. Estimating average single-neuron visual receptive field sizes by fMRI. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6425-6434. PMID: 30867291.
  10. Lee S, Park J, Smirnakis SM. Internal Gain Modulations, But Not Changes in Stimulus Contrast, Preserve the Neural Code. J Neurosci. 2019 02 27; 39(9):1671-1687. PMID: 30647148.
    Citations:    Fields:    
  11. Ash RT, Fahey PG, Park J, Zoghbi HY, Smirnakis SM. Increased Axonal Bouton Stability during Learning in the Mouse Model of MECP2 Duplication Syndrome. eNeuro. 2018 May-Jun; 5(3). PMID: 30105297.
    Citations:    Fields:    Translation:AnimalsCells
  12. Solomon IH, Spera KM, Ryan SL, Helgager J, Andrici J, Zaki SR, Vaitkevicius H, Leon KE, Wilson MR, DeRisi JL, Koo S, Smirnakis SM, De Girolami U. Fatal Powassan Encephalitis (Deer Tick Virus, Lineage II) in a Patient With Fever and Orchitis Receiving Rituximab. JAMA Neurol. 2018 06 01; 75(6):746-750. PMID: 29554185.
    Citations:    Fields:    
  13. Meyer J, Maheshwari A, Noebels J, Smirnakis S. Asynchronous suppression of visual cortex during absence seizures in stargazer mice. Nat Commun. 2018 05 16; 9(1):1938. PMID: 29769525.
    Citations:    Fields:    Translation:HumansAnimalsCells
  14. Meyer JF, Golshani P, Smirnakis SM. The Effect of Single Pyramidal Neuron Firing Within Layer 2/3 and Layer 4 in Mouse V1. Front Neural Circuits. 2018; 12:29. PMID: 29713266.
    Citations:    Fields:    
  15. Papanikolaou A, Keliris GA, Papageorgiou TD, Schiefer U, Logothetis NK, Smirnakis SM. Organization of area hV5/MT+ in subjects with homonymous visual field defects. Neuroimage. 2019 04 15; 190:254-268. PMID: 29627591.
    Citations:    Fields:    
  16. Smyrnakis I, Andreadakis V, Selimis V, Kalaitzakis M, Bachourou T, Kaloutsakis G, Kymionis GD, Smirnakis S, Aslanides IM. RADAR: A novel fast-screening method for reading difficulties with special focus on dyslexia. PLoS One. 2017; 12(8):e0182597. PMID: 28800632.
    Citations:    Fields:    Translation:Humans
  17. Lee S, Meyer JF, Park J, Smirnakis SM. Visually Driven Neuropil Activity and Information Encoding in Mouse Primary Visual Cortex. Front Neural Circuits. 2017; 11:50. PMID: 28785207.
    Citations:    Fields:    Translation:AnimalsCells
  18. Palagina G, Meyer JF, Smirnakis SM. Complex Visual Motion Representation in Mouse Area V1. J Neurosci. 2017 01 04; 37(1):164-183. PMID: 28053039.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Smirnakis SM. Probing Human Visual Deficits with Functional Magnetic Resonance Imaging. Annu Rev Vis Sci. 2016 10 14; 2:171-195. PMID: 28532356.
    Citations: 1     Fields:    Translation:Humans
  20. Lu H, Ash RT, He L, Kee SE, Wang W, Yu D, Hao S, Meng X, Ure K, Ito-Ishida A, Tang B, Sun Y, Ji D, Tang J, Arenkiel BR, Smirnakis SM, Zoghbi HY. Loss and Gain of MeCP2 Cause Similar Hippocampal Circuit Dysfunction that Is Rescued by Deep Brain Stimulation in a Rett Syndrome Mouse Model. Neuron. 2016 Aug 17; 91(4):739-747. PMID: 27499081.
    Citations: 10     Fields:    Translation:AnimalsCells
  21. Papanikolaou A, Keliris GA, Lee S, Logothetis NK, Smirnakis SM. Nonlinear population receptive field changes in human area V5/MT+ of healthy subjects with simulated visual field scotomas. Neuroimage. 2015 Oct 15; 120:176-90. PMID: 26146195.
    Citations: 1     Fields:    Translation:Humans
  22. Olson DM, Andrew Kofke W, O'Phelan K, Gupta PK, Figueroa SA, Smirnakis SM, Leroux PD, Suarez JI. Global monitoring in the neurocritical care unit. Neurocrit Care. 2015 Jun; 22(3):337-47. PMID: 25846709.
    Citations:    Fields:    Translation:Humans
  23. Bershad EM, Rao CP, Vuong KD, Mazabob J, Brown G, Styron SL, Nguyen T, Delledera E, Smirnakis SM, Lazaridis C, Georgiadis AL, Mokracek M, Seipel TJ, Nisbet JJ, Baskaran V, Chang AH, Stewart P, Suarez JI. Multidisciplinary protocol for rapid head computed tomography turnaround time in acute stroke patients. J Stroke Cerebrovasc Dis. 2015 Jun; 24(6):1256-61. PMID: 25920753.
    Citations: 1     Fields:    Translation:Humans
  24. Lee S, Papanikolaou A, Keliris GA, Smirnakis SM. Topographical estimation of visual population receptive fields by FMRI. J Vis Exp. 2015 Feb 03; (96). PMID: 25741774.
    Citations:    Fields:    Translation:HumansCells
  25. Um K, Niu S, Duman JG, Cheng JX, Tu YK, Schwechter B, Liu F, Hiles L, Narayanan AS, Ash RT, Mulherkar S, Alpadi K, Smirnakis SM, Tolias KF. Dynamic control of excitatory synapse development by a Rac1 GEF/GAP regulatory complex. Dev Cell. 2014 Jun 23; 29(6):701-15. PMID: 24960694.
    Citations: 20     Fields:    Translation:AnimalsCells
  26. Papanikolaou A, Keliris GA, Papageorgiou TD, Shao Y, Krapp E, Papageorgiou E, Stingl K, Bruckmann A, Schiefer U, Logothetis NK, Smirnakis SM. Population receptive field analysis of the primary visual cortex complements perimetry in patients with homonymous visual field defects. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):E1656-65. PMID: 24706881.
    Citations: 9     Fields:    Translation:Humans
  27. Ecker AS, Berens P, Cotton RJ, Subramaniyan M, Denfield GH, Cadwell CR, Smirnakis SM, Bethge M, Tolias AS. State dependence of noise correlations in macaque primary visual cortex. Neuron. 2014 Apr 02; 82(1):235-48. PMID: 24698278.
    Citations: 84     Fields:    Translation:AnimalsCells
  28. Jiang M, Ash RT, Baker SA, Suter B, Ferguson A, Park J, Rudy J, Torsky SP, Chao HT, Zoghbi HY, Smirnakis SM. Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome. J Neurosci. 2013 Dec 11; 33(50):19518-33. PMID: 24336718.
    Citations: 42     Fields:    Translation:AnimalsCells
  29. Shao Y, Keliris GA, Papanikolaou A, Fischer MD, Zobor D, Jägle H, Logothetis NK, Smirnakis SM. Visual cortex organisation in a macaque monkey with macular degeneration. Eur J Neurosci. 2013 Nov; 38(10):3456-64. PMID: 24033706.
    Citations: 1     Fields:    Translation:Animals
  30. Lee S, Papanikolaou A, Logothetis NK, Smirnakis SM, Keliris GA. A new method for estimating population receptive field topography in visual cortex. Neuroimage. 2013 Nov 01; 81:144-157. PMID: 23684878.
    Citations: 12     Fields:    Translation:Humans
  31. Smyrnakis I, Smirnakis S. Information transfer through stochastic transmission of a linear combination of rates. Neural Comput. 2013 Sep; 25(9):2265-302. PMID: 23663145.
    Citations:    Fields:    Translation:HumansAnimalsCells
  32. Hannawi Y, Smirnakis SM. Emerging subspecialties: neuroinformatics. Neurology. 2013 Apr 09; 80(15):e166-8. PMID: 23569003.
    Citations: 2     Fields:    Translation:Humans
  33. Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL. Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. Eur J Neurosci. 2013 Apr; 37(8):1203-20. PMID: 23347239.
    Citations: 27     Fields:    Translation:AnimalsCells
  34. Dominik Fischer M, Zobor D, Keliris GA, Shao Y, Seeliger MW, Haverkamp S, Jägle H, Logothetis NK, Smirnakis SM. Detailed functional and structural characterization of a macular lesion in a rhesus macaque. Doc Ophthalmol. 2012 Dec; 125(3):179-94. PMID: 22923360.
    Citations: 1     Fields:    Translation:AnimalsCells
  35. Suarez JI, Geocadin R, Hall C, Le Roux PD, Smirnakis S, Wijman CA, Zaidat OO. The neurocritical care research network: NCRN. Neurocrit Care. 2012 Feb; 16(1):29-34. PMID: 21792751.
    Citations: 3     Fields:    Translation:Humans
  36. Wijman CA, Smirnakis SM, Vespa P, Szigeti K, Ziai WC, Ning MM, Rosand J, Hanley DF, Geocadin R, Hall C, Le Roux PD, Suarez JI, Zaidat OO. Research and technology in neurocritical care. Neurocrit Care. 2012 Feb; 16(1):42-54. PMID: 21796494.
    Citations: 5     Fields:    Translation:Humans
  37. Nichols JA, Nichols AR, Smirnakis SM, Engineer ND, Kilgard MP, Atzori M. Vagus nerve stimulation modulates cortical synchrony and excitability through the activation of muscarinic receptors. Neuroscience. 2011 Aug 25; 189:207-14. PMID: 21627982.
    Citations: 29     Fields:    Translation:AnimalsPHPublic Health
  38. Wandell BA, Smirnakis SM. Plasticity and stability of visual field maps in adult primary visual cortex. Nat Rev Neurosci. 2009 Dec; 10(12):873-84. PMID: 19904279.
    Citations: 54     Fields:    Translation:HumansAnimals
  39. Golshani P, Gonçalves JT, Khoshkhoo S, Mostany R, Smirnakis S, Portera-Cailliau C. Internally mediated developmental desynchronization of neocortical network activity. J Neurosci. 2009 Sep 02; 29(35):10890-9. PMID: 19726647.
    Citations: 65     Fields:    Translation:Animals
  40. Schmid MC, Panagiotaropoulos T, Augath MA, Logothetis NK, Smirnakis SM. Visually driven activation in macaque areas V2 and V3 without input from the primary visual cortex. PLoS One. 2009; 4(5):e5527. PMID: 19436733.
    Citations: 18     Fields:    Translation:AnimalsCells
  41. Tehovnik EJ, Slocum WM, Smirnakis SM, Tolias AS. Microstimulation of visual cortex to restore vision. Prog Brain Res. 2009; 175:347-75. PMID: 19660667.
    Citations: 17     Fields:    Translation:HumansAnimals
  42. Smirnakis SM, Schmid MC, Weber B, Tolias AS, Augath M, Logothetis NK. Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization. J Cereb Blood Flow Metab. 2007 Jun; 27(6):1248-61. PMID: 17213863.
    Citations: 26     Fields:    Translation:Animals
  43. Schmid MC, Oeltermann A, Juchem C, Logothetis NK, Smirnakis SM. Simultaneous EEG and fMRI in the macaque monkey at 4.7 Tesla. Magn Reson Imaging. 2006 May; 24(4):335-42. PMID: 16677938.
    Citations: 3     Fields:    Translation:Animals
  44. Smirnakis SM, Brewer AA, Schmid MC, Tolias AS, Schüz A, Augath M, Inhoffen W, Wandell BA, Logothetis NK. Lack of long-term cortical reorganization after macaque retinal lesions. Nature. 2005 May 19; 435(7040):300-7. PMID: 15902248.
    Citations: 56     Fields:    Translation:Animals
  45. Tolias AS, Keliris GA, Smirnakis SM, Logothetis NK. Neurons in macaque area V4 acquire directional tuning after adaptation to motion stimuli. Nat Neurosci. 2005 May; 8(5):591-3. PMID: 15834417.
    Citations: 40     Fields:    Translation:AnimalsCells
  46. Ning MM, Smirnakis S, Furie KL, Sheen VL. Adult acute disseminated encephalomyelitis associated with poststreptococcal infection. J Clin Neurosci. 2005 Apr; 12(3):298-300. PMID: 15851086.
    Citations: 2     Fields:    Translation:Humans
  47. Tolias AS, Smirnakis SM, Augath MA, Trinath T, Logothetis NK. Motion processing in the macaque: revisited with functional magnetic resonance imaging. J Neurosci. 2001 Nov 01; 21(21):8594-601. PMID: 11606647.
    Citations: 16     Fields:    Translation:Animals
  48. Tolias AS, Moore T, Smirnakis SM, Tehovnik EJ, Siapas AG, Schiller PH. Eye movements modulate visual receptive fields of V4 neurons. Neuron. 2001 Mar; 29(3):757-67. PMID: 11301034.
    Citations: 80     Fields:    Translation:AnimalsCells
  49. Smirnakis SM, Berry MJ, Warland DK, Bialek W, Meister M. Adaptation of retinal processing to image contrast and spatial scale. Nature. 1997 Mar 06; 386(6620):69-73. PMID: 9052781.
    Citations: 102     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.