Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Thomas W Chittenden, Ph.D.

Title
Institution
Department
Address
Phone

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M. Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium. J Exp Med. 2019 Jun 13. PMID: 31196980.
    Citations:    
  2. Baylon JL, Cilfone NA, Gulcher JR, Chittenden TW. Enhancing Retrosynthetic Reaction Prediction with Deep Learning Using Multiscale Reaction Classification. J Chem Inf Model. 2019 Feb 25; 59(2):673-688. PMID: 30642173.
    Citations:    Fields:    
  3. Ayers KL, Glicksberg BS, Garfield AS, Longerich S, White JA, Yang P, Du L, Chittenden TW, Gulcher JR, Roy S, Fiedorek F, Gottesdiener K, Cohen S, North KE, Schadt EE, Li SD, Chen R, Van der Ploeg LHT. Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment. J Clin Endocrinol Metab. 2018 07 01; 103(7):2601-2612. PMID: 29726959.
    Citations:    Fields:    Translation:HumansCells
  4. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2018 02 14; 9(1):720. PMID: 29445140.
    Citations:    Fields:    
  5. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2017 12 15; 8(1):2149. PMID: 29247167.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018 02 02; 359(6375):555-559. PMID: 29217584.
    Citations: 9     Fields:    Translation:HumansCells
  7. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. FGF-dependent metabolic control of vascular development. Nature. 2017 05 11; 545(7653):224-228. PMID: 28467822.
    Citations: 16     Fields:    Translation:AnimalsCells
  8. Trakhtenberg EF, Pho N, Holton KM, Chittenden TW, Goldberg JL, Dong L. Cell types differ in global coordination of splicing and proportion of highly expressed genes. Sci Rep. 2016 08 31; 6:32249. PMID: 27577089.
    Citations: 2     Fields:    Translation:AnimalsCells
  9. Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D'Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science. 2015 Oct 02; 350(6256):94-98. PMID: 26430121.
    Citations: 70     Fields:    Translation:HumansCells
  10. Galligan JT, Martinez-Noël G, Arndt V, Hayes S, Chittenden TW, Harper JW, Howley PM. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. J Proteome Res. 2015 Feb 06; 14(2):953-66. PMID: 25476789.
    Citations: 12     Fields:    Translation:Humans
  11. Balch C, Arias-Pulido H, Banerjee S, Lancaster AK, Clark KB, Perilstein M, Hawkins B, Rhodes J, Sliz P, Wilkins J, Chittenden TW. Science and technology consortia in U.S. biomedical research: a paradigm shift in response to unsustainable academic growth. Bioessays. 2015 Feb; 37(2):119-22. PMID: 25387399.
    Citations: 3     Fields:    
  12. Chittenden TW, Howe EA, Taylor JM, Mar JC, Aryee MJ, Gómez H, Sultana R, Braisted J, Nair SJ, Quackenbush J, Holmes C. nEASE: a method for gene ontology subclassification of high-throughput gene expression data. Bioinformatics. 2012 Mar 01; 28(5):726-8. PMID: 22247278.
    Citations: 4     Fields:    Translation:Humans
  13. Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, Lanahan AA, Taylor JM, Holmes C, Hahn WC, Zhao JJ, Iglehart JD, Quackenbush J. Therapeutic implications of GIPC1 silencing in cancer. PLoS One. 2010 Dec 30; 5(12):e15581. PMID: 21209904.
    Citations: 12     Fields:    Translation:HumansCells
  14. Chittenden TW, Howe EA, Culhane AC, Sultana R, Taylor JM, Holmes C, Quackenbush J. Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Genomics. 2008 Jun; 91(6):508-11. PMID: 18434084.
    Citations: 28     Fields:    Translation:Humans
  15. Dedkov EI, Thomas MT, Sonka M, Yang F, Chittenden TW, Rhodes JM, Simons M, Ritman EL, Tomanek RJ. Synectin/syndecan-4 regulate coronary arteriolar growth during development. Dev Dyn. 2007 Jul; 236(7):2004-10. PMID: 17576142.
    Citations: 14     Fields:    Translation:Animals
  16. Kaleth AS, Chittenden TW, Hawkins BJ, Hargens TA, Guill SG, Zedalis D, Gregg JM, Herbert WG. Unique cardiopulmonary exercise test responses in overweight middle-aged adults with obstructive sleep apnea. Sleep Med. 2007 Mar; 8(2):160-8. PMID: 17275399.
    Citations: 17     Fields:    Translation:Humans
  17. Chittenden TW, Sherman JA, Xiong F, Hall AE, Lanahan AA, Taylor JM, Duan H, Pearlman JD, Moore JH, Schwartz SM, Simons M. Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization. Circulation. 2006 Oct 24; 114(17):1811-20. PMID: 17043168.
    Citations: 17     Fields:    Translation:HumansCells
  18. Lanahan AA, Chittenden TW, Mulvihill E, Smith K, Schwartz S, Simons M. Synectin-dependent gene expression in endothelial cells. Physiol Genomics. 2006 Nov 27; 27(3):380-90. PMID: 16940428.
    Citations: 9     Fields:    Translation:AnimalsCells
  19. Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Tkachenko EV, Elfenbein A, Ruiz de Almodovar C, Dedkov E, Tomanek R, Li W, Westmore M, Singh JP, Horowitz A, Mulligan-Kehoe MJ, Moodie KL, Zhuang ZW, Carmeliet P, Simons M. Selective regulation of arterial branching morphogenesis by synectin. Dev Cell. 2006 Jun; 10(6):783-95. PMID: 16740480.
    Citations: 65     Fields:    Translation:AnimalsCells
  20. Qin J, Chittenden TW, Gao L, Pearlman JD. Automated migration analysis based on cell texture: method & reliability. BMC Cell Biol. 2005 Mar 03; 6(1):9. PMID: 15743539.
    Citations: 2     Fields:    Translation:HumansCells
  21. Zhang Y, Chittenden T, Simons M. Characterization of synectin expression and promoter activity. Gene. 2004 Nov 10; 342(1):29-34. PMID: 15527962.
    Citations: 3     Fields:    Translation:AnimalsCells
  22. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL, Zambetti GP. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003 Oct; 4(4):321-8. PMID: 14585359.
    Citations: 330     Fields:    Translation:AnimalsCells
  23. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003 Mar; 11(3):577-90. PMID: 12667443.
    Citations: 451     Fields:    Translation:HumansAnimalsCells
  24. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11318-23. PMID: 11572983.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  25. Zhou XM, Liu Y, Payne G, Lutz RJ, Chittenden T. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem. 2000 Aug 11; 275(32):25046-51. PMID: 10837473.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  26. Gu Z, Flemington C, Chittenden T, Zambetti GP. ei24, a p53 response gene involved in growth suppression and apoptosis. Mol Cell Biol. 2000 Jan; 20(1):233-41. PMID: 10594026.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  27. Holinger EP, Chittenden T, Lutz RJ. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 07; 274(19):13298-304. PMID: 10224090.
    Citations: 40     Fields:    Translation:HumansCells
  28. Ulrich E, Kauffmann-Zeh A, Hueber AO, Williamson J, Chittenden T, Ma A, Evan G. Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member. Genomics. 1997 Sep 01; 44(2):195-200. PMID: 9299236.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  29. Ink B, Zörnig M, Baum B, Hajibagheri N, James C, Chittenden T, Evan G. Human Bak induces cell death in Schizosaccharomyces pombe with morphological changes similar to those with apoptosis in mammalian cells. Mol Cell Biol. 1997 May; 17(5):2468-74. PMID: 9111315.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  30. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene. 1996 Mar 21; 12(6):1181-7. PMID: 8649819.
    Citations: 15     Fields:    Translation:AnimalsCells
  31. Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ, et al. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene. 1995 Nov 02; 11(9):1921-8. PMID: 7478623.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
  32. Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC. Induction of apoptosis by the Bcl-2 homologue Bak. Nature. 1995 Apr 20; 374(6524):733-6. PMID: 7715730.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  33. Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79. PMID: 7958924.
    Citations: 104     Fields:    Translation:HumansCells
  34. Livingston DM, Kaelin W, Chittenden T, Qin X. Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture). Br J Cancer. 1993 Aug; 68(2):264-8. PMID: 8347480.
    Citations: 3     Fields:    Translation:HumansCells
  35. Chittenden T, Livingston DM, DeCaprio JA. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol. 1993 Jul; 13(7):3975-83. PMID: 8321204.
    Citations: 25     Fields:    Translation:HumansCells
  36. Kaelin WG, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell. 1992 Jul 24; 70(2):351-64. PMID: 1638635.
    Citations: 297     Fields:    Translation:Cells
  37. Qin XQ, Chittenden T, Livingston DM, Kaelin WG. Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 1992 Jun; 6(6):953-64. PMID: 1534305.
    Citations: 156     Fields:    Translation:HumansCells
  38. Shirodkar S, Ewen M, DeCaprio JA, Morgan J, Livingston DM, Chittenden T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell. 1992 Jan 10; 68(1):157-66. PMID: 1531040.
    Citations: 189     Fields:    Translation:HumansCells
  39. Chittenden T, Livingston DM, Kaelin WG. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell. 1991 Jun 14; 65(6):1073-82. PMID: 1828394.
    Citations: 136     Fields:    Translation:Cells
  40. Chittenden T, Livingston DM, Kaelin WG. RB associates with an E2F-like, sequence-specific DNA-binding protein. Cold Spring Harb Symp Quant Biol. 1991; 56:187-95. PMID: 1819485.
    Citations: 7     Fields:    Translation:HumansCells
  41. Oh SJ, Chittenden T, Levine AJ. Identification of cellular factors that bind specifically to the Epstein-Barr virus origin of DNA replication. J Virol. 1991 Jan; 65(1):514-9. PMID: 1845905.
    Citations: 6     Fields:    Translation:HumansCells
  42. Chittenden T, Lupton S, Levine AJ. Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication. J Virol. 1989 Jul; 63(7):3016-25. PMID: 2542609.
    Citations: 34     Fields:    Translation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Chittenden's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (299)
Explore
_
Co-Authors (20)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.