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profileThomas W Chittenden, Ph.D.

TitleLecturer on Pediatrics, Part-time
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildren's Hospital
300 Longwood Ave
Boston MA 02115
Phone617/432-2000
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. FGF-dependent metabolic control of vascular development. Nature. 2017 05 11; 545(7653):224-228. PMID: 28467822.
    View in: PubMed
  2. Trakhtenberg EF, Pho N, Holton KM, Chittenden TW, Goldberg JL, Dong L. Cell types differ in global coordination of splicing and proportion of highly expressed genes. Sci Rep. 2016 Aug 31; 6:32249. PMID: 27577089; PMCID: PMC5006053.
  3. Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D'Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science. 2015 Oct 02; 350(6256):94-98. PMID: 26430121; PMCID: PMC4664477 [Available on 10/02/16].
  4. Galligan JT, Martinez-Noël G, Arndt V, Hayes S, Chittenden TW, Harper JW, Howley PM. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. J Proteome Res. 2015 Feb 06; 14(2):953-66. PMID: 25476789; PMCID: PMC4324439.
  5. Balch C, Arias-Pulido H, Banerjee S, Lancaster AK, Clark KB, Perilstein M, Hawkins B, Rhodes J, Sliz P, Wilkins J, Chittenden TW. Science and technology consortia in U.S. biomedical research: a paradigm shift in response to unsustainable academic growth. Bioessays. 2015 Feb; 37(2):119-22. PMID: 25387399.
    View in: PubMed
  6. Chittenden TW, Howe EA, Taylor JM, Mar JC, Aryee MJ, Gómez H, Sultana R, Braisted J, Nair SJ, Quackenbush J, Holmes C. nEASE: a method for gene ontology subclassification of high-throughput gene expression data. Bioinformatics. 2012 Mar 01; 28(5):726-8. PMID: 22247278.
    View in: PubMed
  7. Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, Lanahan AA, Taylor JM, Holmes C, Hahn WC, Zhao JJ, Iglehart JD, Quackenbush J. Therapeutic implications of GIPC1 silencing in cancer. PLoS One. 2010 Dec 30; 5(12):e15581. PMID: 21209904; PMCID: PMC3012716.
  8. Chittenden TW, Howe EA, Culhane AC, Sultana R, Taylor JM, Holmes C, Quackenbush J. Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Genomics. 2008 Jun; 91(6):508-11. PMID: 18434084; PMCID: PMC2492759.
  9. Dedkov EI, Thomas MT, Sonka M, Yang F, Chittenden TW, Rhodes JM, Simons M, Ritman EL, Tomanek RJ. Synectin/syndecan-4 regulate coronary arteriolar growth during development. Dev Dyn. 2007 Jul; 236(7):2004-10. PMID: 17576142.
    View in: PubMed
  10. Kaleth AS, Chittenden TW, Hawkins BJ, Hargens TA, Guill SG, Zedalis D, Gregg JM, Herbert WG. Unique cardiopulmonary exercise test responses in overweight middle-aged adults with obstructive sleep apnea. Sleep Med. 2007 Mar; 8(2):160-8. PMID: 17275399.
    View in: PubMed
  11. Chittenden TW, Sherman JA, Xiong F, Hall AE, Lanahan AA, Taylor JM, Duan H, Pearlman JD, Moore JH, Schwartz SM, Simons M. Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization. Circulation. 2006 Oct 24; 114(17):1811-20. PMID: 17043168.
    View in: PubMed
  12. Lanahan AA, Chittenden TW, Mulvihill E, Smith K, Schwartz S, Simons M. Synectin-dependent gene expression in endothelial cells. Physiol Genomics. 2006 Nov 27; 27(3):380-90. PMID: 16940428.
    View in: PubMed
  13. Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Tkachenko EV, Elfenbein A, Ruiz de Almodovar C, Dedkov E, Tomanek R, Li W, Westmore M, Singh JP, Horowitz A, Mulligan-Kehoe MJ, Moodie KL, Zhuang ZW, Carmeliet P, Simons M. Selective regulation of arterial branching morphogenesis by synectin. Dev Cell. 2006 Jun; 10(6):783-95. PMID: 16740480.
    View in: PubMed
  14. Qin J, Chittenden TW, Gao L, Pearlman JD. Automated migration analysis based on cell texture: method & reliability. BMC Cell Biol. 2005 Mar 03; 6(1):9. PMID: 15743539; PMCID: PMC554989.
  15. Zhang Y, Chittenden T, Simons M. Characterization of synectin expression and promoter activity. Gene. 2004 Nov 10; 342(1):29-34. PMID: 15527962.
    View in: PubMed
  16. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL, Zambetti GP. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003 Oct; 4(4):321-8. PMID: 14585359.
    View in: PubMed
  17. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003 Mar; 11(3):577-90. PMID: 12667443.
    View in: PubMed
  18. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11318-23. PMID: 11572983; PMCID: PMC58727.
  19. Zhou XM, Liu Y, Payne G, Lutz RJ, Chittenden T. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem. 2000 Aug 11; 275(32):25046-51. PMID: 10837473.
    View in: PubMed
  20. Gu Z, Flemington C, Chittenden T, Zambetti GP. ei24, a p53 response gene involved in growth suppression and apoptosis. Mol Cell Biol. 2000 Jan; 20(1):233-41. PMID: 10594026; PMCID: PMC85079.
  21. Holinger EP, Chittenden T, Lutz RJ. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 07; 274(19):13298-304. PMID: 10224090.
    View in: PubMed
  22. Ulrich E, Kauffmann-Zeh A, Hueber AO, Williamson J, Chittenden T, Ma A, Evan G. Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member. Genomics. 1997 Sep 01; 44(2):195-200. PMID: 9299236.
    View in: PubMed
  23. Ink B, Zörnig M, Baum B, Hajibagheri N, James C, Chittenden T, Evan G. Human Bak induces cell death in Schizosaccharomyces pombe with morphological changes similar to those with apoptosis in mammalian cells. Mol Cell Biol. 1997 May; 17(5):2468-74. PMID: 9111315; PMCID: PMC232095.
  24. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene. 1996 Mar 21; 12(6):1181-7. PMID: 8649819.
    View in: PubMed
  25. Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ, et al. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene. 1995 Nov 02; 11(9):1921-8. PMID: 7478623.
    View in: PubMed
  26. Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC. Induction of apoptosis by the Bcl-2 homologue Bak. Nature. 1995 Apr 20; 374(6524):733-6. PMID: 7715730.
    View in: PubMed
  27. Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79. PMID: 7958924.
    View in: PubMed
  28. Livingston DM, Kaelin W, Chittenden T, Qin X. Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture). Br J Cancer. 1993 Aug; 68(2):264-8. PMID: 8347480; PMCID: PMC1968582.
  29. Chittenden T, Livingston DM, DeCaprio JA. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol. 1993 Jul; 13(7):3975-83. PMID: 8321204; PMCID: PMC359943.
  30. Kaelin WG, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell. 1992 Jul 24; 70(2):351-64. PMID: 1638635.
    View in: PubMed
  31. Qin XQ, Chittenden T, Livingston DM, Kaelin WG. Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 1992 Jun; 6(6):953-64. PMID: 1534305.
    View in: PubMed
  32. Shirodkar S, Ewen M, DeCaprio JA, Morgan J, Livingston DM, Chittenden T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell. 1992 Jan 10; 68(1):157-66. PMID: 1531040.
    View in: PubMed
  33. Chittenden T, Livingston DM, Kaelin WG. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell. 1991 Jun 14; 65(6):1073-82. PMID: 1828394.
    View in: PubMed
  34. Chittenden T, Livingston DM, Kaelin WG. RB associates with an E2F-like, sequence-specific DNA-binding protein. Cold Spring Harb Symp Quant Biol. 1991; 56:187-95. PMID: 1819485.
    View in: PubMed
  35. Oh SJ, Chittenden T, Levine AJ. Identification of cellular factors that bind specifically to the Epstein-Barr virus origin of DNA replication. J Virol. 1991 Jan; 65(1):514-9. PMID: 1845905; PMCID: PMC240549.
  36. Chittenden T, Lupton S, Levine AJ. Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication. J Virol. 1989 Jul; 63(7):3016-25. PMID: 2542609; PMCID: PMC250856.
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