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Thomas W Chittenden, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Carapito R, Li R, Helms J, Carapito C, Gujja S, Rolli V, Guimaraes R, Malagon-Lopez J, Spinnhirny P, Lederle A, Mohseninia R, Hirschler A, Muller L, Bastard P, Gervais A, Zhang Q, Danion F, Ruch Y, Schenck M, Collange O, Chamaraux-Tran TN, Molitor A, Pichot A, Bernard A, Tahar O, Bibi-Triki S, Wu H, Paul N, Mayeur S, Larnicol A, Laumond G, Frappier J, Schmidt S, Hanauer A, Macquin C, Stemmelen T, Simons M, Mariette X, Hermine O, Fafi-Kremer S, Goichot B, Drenou B, Kuteifan K, Pottecher J, Mertes PM, Kailasan S, Aman MJ, Pin E, Nilsson P, Thomas A, Viari A, Sanlaville D, Schneider F, Sibilia J, Tharaux PL, Casanova JL, Hansmann Y, Lidar D, Radosavljevic M, Gulcher JR, Meziani F, Moog C, Chittenden TW, Bahram S. Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort. Sci Transl Med. 2022 Jan 19; 14(628):eabj7521. PMID: 34698500.
    Citations: 6     Fields:    Translation:HumansCells
  2. Li RY, Gujja S, Bajaj SR, Gamel OE, Cilfone N, Gulcher JR, Lidar DA, Chittenden TW. Quantum processor-inspired machine learning in the biomedical sciences. Patterns (N Y). 2021 Jun 11; 2(6):100246. PMID: 34179840.
  3. Simons M, Gulcher JR, Chittenden TW. In silico phenotype projection of endothelial ERK1/2 signaling. Aging (Albany NY). 2020 06 12; 12(11):10001-10003. PMID: 32530820.
    Citations:    Fields:    Translation:HumansCells
  4. Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M. Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell Stem Cell. 2020 04 02; 26(4):542-557.e11. PMID: 32243809.
    Citations: 39     Fields:    Translation:AnimalsCells
  5. Li G, Wang M, Caulk AW, Cilfone NA, Gujja S, Qin L, Chen PY, Chen Z, Yousef S, Jiao Y, He C, Jiang B, Korneva A, Bersi MR, Wang G, Liu X, Mehta S, Geirsson A, Gulcher JR, Chittenden TW, Simons M, Humphrey JD, Tellides G. Chronic mTOR activation induces a degradative smooth muscle cell phenotype. J Clin Invest. 2020 03 02; 130(3):1233-1251. PMID: 32039915; PMCID: PMC7269581.
    Citations: 11     Fields:    Translation:AnimalsCells
  6. Simons M, Chen PY, Chittenden TW. Resilience, disease and the age of single cell science. Aging (Albany NY). 2020 02 10; 12(3):2028-2029. PMID: 32039835.
    Citations: 1     Fields:    Translation:Humans
  7. Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone NA, Kauffman KJ, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson DG, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz MA, Pober JS, Chittenden TW, Tellides G, Simons M. Endothelial TGF-ß signalling drives vascular inflammation and atherosclerosis. Nat Metab. 2019 09; 1(9):912-926. PMID: 31572976.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  8. Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M. Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium. J Exp Med. 2019 08 05; 216(8):1874-1890. PMID: 31196980; PMCID: PMC6683988.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  9. Baylon JL, Cilfone NA, Gulcher JR, Chittenden TW. Enhancing Retrosynthetic Reaction Prediction with Deep Learning Using Multiscale Reaction Classification. J Chem Inf Model. 2019 02 25; 59(2):673-688. PMID: 30642173.
    Citations: 9     Fields:    
  10. Ayers KL, Glicksberg BS, Garfield AS, Longerich S, White JA, Yang P, Du L, Chittenden TW, Gulcher JR, Roy S, Fiedorek F, Gottesdiener K, Cohen S, North KE, Schadt EE, Li SD, Chen R, Van der Ploeg LHT. Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment. J Clin Endocrinol Metab. 2018 07 01; 103(7):2601-2612. PMID: 29726959.
    Citations: 19     Fields:    Translation:HumansCells
  11. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2018 02 14; 9(1):720. PMID: 29445140.
    Citations: 1     Fields:    
  12. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2017 12 15; 8(1):2149. PMID: 29247167.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  13. Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA. Aging and neurodegeneration are associated with increased mutations in single human neurons. Science. 2018 02 02; 359(6375):555-559. PMID: 29217584; PMCID: PMC5831169.
    Citations: 180     Fields:    Translation:HumansCells
  14. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. FGF-dependent metabolic control of vascular development. Nature. 2017 05 11; 545(7653):224-228. PMID: 28467822; PMCID: PMC5427179.
    Citations: 108     Fields:    Translation:AnimalsCells
  15. Trakhtenberg EF, Pho N, Holton KM, Chittenden TW, Goldberg JL, Dong L. Cell types differ in global coordination of splicing and proportion of highly expressed genes. Sci Rep. 2016 08 31; 6:32249. PMID: 27577089.
    Citations: 10     Fields:    Translation:AnimalsCells
  16. Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D'Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA. Somatic mutation in single human neurons tracks developmental and transcriptional history. Science. 2015 Oct 02; 350(6256):94-98. PMID: 26430121; PMCID: PMC4664477.
    Citations: 229     Fields:    Translation:HumansCells
  17. Galligan JT, Martinez-Noël G, Arndt V, Hayes S, Chittenden TW, Harper JW, Howley PM. Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2. J Proteome Res. 2015 Feb 06; 14(2):953-66. PMID: 25476789; PMCID: PMC4324439.
    Citations: 23     Fields:    Translation:Humans
  18. Balch C, Arias-Pulido H, Banerjee S, Lancaster AK, Clark KB, Perilstein M, Hawkins B, Rhodes J, Sliz P, Wilkins J, Chittenden TW. Science and technology consortia in U.S. biomedical research: a paradigm shift in response to unsustainable academic growth. Bioessays. 2015 Feb; 37(2):119-22. PMID: 25387399.
    Citations: 3     Fields:    
  19. Chittenden TW, Howe EA, Taylor JM, Mar JC, Aryee MJ, Gómez H, Sultana R, Braisted J, Nair SJ, Quackenbush J, Holmes C. nEASE: a method for gene ontology subclassification of high-throughput gene expression data. Bioinformatics. 2012 Mar 01; 28(5):726-8. PMID: 22247278; PMCID: PMC6903781.
    Citations: 5     Fields:    Translation:Humans
  20. Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, Lanahan AA, Taylor JM, Holmes C, Hahn WC, Zhao JJ, Iglehart JD, Quackenbush J. Therapeutic implications of GIPC1 silencing in cancer. PLoS One. 2010 Dec 30; 5(12):e15581. PMID: 21209904; PMCID: PMC3012716.
    Citations: 19     Fields:    Translation:HumansCells
  21. Chittenden TW, Howe EA, Culhane AC, Sultana R, Taylor JM, Holmes C, Quackenbush J. Functional classification analysis of somatically mutated genes in human breast and colorectal cancers. Genomics. 2008 Jun; 91(6):508-11. PMID: 18434084.
    Citations: 34     Fields:    Translation:Humans
  22. Dedkov EI, Thomas MT, Sonka M, Yang F, Chittenden TW, Rhodes JM, Simons M, Ritman EL, Tomanek RJ. Synectin/syndecan-4 regulate coronary arteriolar growth during development. Dev Dyn. 2007 Jul; 236(7):2004-10. PMID: 17576142.
    Citations: 15     Fields:    Translation:Animals
  23. Kaleth AS, Chittenden TW, Hawkins BJ, Hargens TA, Guill SG, Zedalis D, Gregg JM, Herbert WG. Unique cardiopulmonary exercise test responses in overweight middle-aged adults with obstructive sleep apnea. Sleep Med. 2007 Mar; 8(2):160-8. PMID: 17275399.
    Citations: 28     Fields:    Translation:Humans
  24. Chittenden TW, Sherman JA, Xiong F, Hall AE, Lanahan AA, Taylor JM, Duan H, Pearlman JD, Moore JH, Schwartz SM, Simons M. Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization. Circulation. 2006 Oct 24; 114(17):1811-20. PMID: 17043168.
    Citations: 19     Fields:    Translation:HumansCells
  25. Lanahan AA, Chittenden TW, Mulvihill E, Smith K, Schwartz S, Simons M. Synectin-dependent gene expression in endothelial cells. Physiol Genomics. 2006 Nov 27; 27(3):380-90. PMID: 16940428.
    Citations: 9     Fields:    Translation:AnimalsCells
  26. Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Tkachenko EV, Elfenbein A, Ruiz de Almodovar C, Dedkov E, Tomanek R, Li W, Westmore M, Singh JP, Horowitz A, Mulligan-Kehoe MJ, Moodie KL, Zhuang ZW, Carmeliet P, Simons M. Selective regulation of arterial branching morphogenesis by synectin. Dev Cell. 2006 Jun; 10(6):783-95. PMID: 16740480.
    Citations: 72     Fields:    Translation:AnimalsCells
  27. Qin J, Chittenden TW, Gao L, Pearlman JD. Automated migration analysis based on cell texture: method & reliability. BMC Cell Biol. 2005 Mar 03; 6(1):9. PMID: 15743539; PMCID: PMC554989.
    Citations: 2     Fields:    Translation:HumansCells
  28. Zhang Y, Chittenden T, Simons M. Characterization of synectin expression and promoter activity. Gene. 2004 Nov 10; 342(1):29-34. PMID: 15527962.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. Jeffers JR, Parganas E, Lee Y, Yang C, Wang J, Brennan J, MacLean KH, Han J, Chittenden T, Ihle JN, McKinnon PJ, Cleveland JL, Zambetti GP. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003 Oct; 4(4):321-8. PMID: 14585359.
    Citations: 392     Fields:    Translation:AnimalsCells
  30. Mihara M, Erster S, Zaika A, Petrenko O, Chittenden T, Pancoska P, Moll UM. p53 has a direct apoptogenic role at the mitochondria. Mol Cell. 2003 Mar; 11(3):577-90. PMID: 12667443.
    Citations: 577     Fields:    Translation:HumansAnimalsCells
  31. Han J, Flemington C, Houghton AB, Gu Z, Zambetti GP, Lutz RJ, Zhu L, Chittenden T. Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11318-23. PMID: 11572983; PMCID: PMC58727.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  32. Zhou XM, Liu Y, Payne G, Lutz RJ, Chittenden T. Growth factors inactivate the cell death promoter BAD by phosphorylation of its BH3 domain on Ser155. J Biol Chem. 2000 Aug 11; 275(32):25046-51. PMID: 10837473.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  33. Gu Z, Flemington C, Chittenden T, Zambetti GP. ei24, a p53 response gene involved in growth suppression and apoptosis. Mol Cell Biol. 2000 Jan; 20(1):233-41. PMID: 10594026; PMCID: PMC85079.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  34. Holinger EP, Chittenden T, Lutz RJ. Bak BH3 peptides antagonize Bcl-xL function and induce apoptosis through cytochrome c-independent activation of caspases. J Biol Chem. 1999 May 07; 274(19):13298-304. PMID: 10224090.
    Citations: 48     Fields:    Translation:HumansCells
  35. Ulrich E, Kauffmann-Zeh A, Hueber AO, Williamson J, Chittenden T, Ma A, Evan G. Gene structure, cDNA sequence, and expression of murine Bak, a proapoptotic Bcl-2 family member. Genomics. 1997 Sep 01; 44(2):195-200. PMID: 9299236.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  36. Ink B, Zörnig M, Baum B, Hajibagheri N, James C, Chittenden T, Evan G. Human Bak induces cell death in Schizosaccharomyces pombe with morphological changes similar to those with apoptosis in mammalian cells. Mol Cell Biol. 1997 May; 17(5):2468-74. PMID: 9111315.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  37. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene. 1996 Mar 21; 12(6):1181-7. PMID: 8649819.
    Citations: 20     Fields:    Translation:AnimalsCells
  38. Chittenden T, Flemington C, Houghton AB, Ebb RG, Gallo GJ, Elangovan B, Chinnadurai G, Lutz RJ. A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. EMBO J. 1995 Nov 15; 14(22):5589-96. PMID: 8521816; PMCID: PMC394673.
    Citations: 116     Fields:    Translation:AnimalsCells
  39. Boyd JM, Gallo GJ, Elangovan B, Houghton AB, Malstrom S, Avery BJ, Ebb RG, Subramanian T, Chittenden T, Lutz RJ, et al. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins. Oncogene. 1995 Nov 02; 11(9):1921-8. PMID: 7478623.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  40. Chittenden T, Harrington EA, O'Connor R, Flemington C, Lutz RJ, Evan GI, Guild BC. Induction of apoptosis by the Bcl-2 homologue Bak. Nature. 1995 Apr 20; 374(6524):733-6. PMID: 7715730.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  41. Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM. E2F-4, a new member of the E2F transcription factor family, interacts with p107. Genes Dev. 1994 Nov 15; 8(22):2665-79. PMID: 7958924.
    Citations: 114     Fields:    Translation:HumansCells
  42. Livingston DM, Kaelin W, Chittenden T, Qin X. Structural and functional contributions to the G1 blocking action of the retinoblastoma protein. (the 1992 Gordon Hamilton Fairley Memorial Lecture). Br J Cancer. 1993 Aug; 68(2):264-8. PMID: 8347480; PMCID: PMC1968582.
    Citations: 3     Fields:    Translation:HumansCells
  43. Chittenden T, Livingston DM, DeCaprio JA. Cell cycle analysis of E2F in primary human T cells reveals novel E2F complexes and biochemically distinct forms of free E2F. Mol Cell Biol. 1993 Jul; 13(7):3975-83. PMID: 8321204.
    Citations: 25     Fields:    Translation:HumansCells
  44. Kaelin WG, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA, et al. Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell. 1992 Jul 24; 70(2):351-64. PMID: 1638635.
    Citations: 308     Fields:    Translation:Cells
  45. Qin XQ, Chittenden T, Livingston DM, Kaelin WG. Identification of a growth suppression domain within the retinoblastoma gene product. Genes Dev. 1992 Jun; 6(6):953-64. PMID: 1534305.
    Citations: 162     Fields:    Translation:HumansCells
  46. Shirodkar S, Ewen M, DeCaprio JA, Morgan J, Livingston DM, Chittenden T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell. 1992 Jan 10; 68(1):157-66. PMID: 1531040.
    Citations: 193     Fields:    Translation:HumansCells
  47. Chittenden T, Livingston DM, Kaelin WG. The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein. Cell. 1991 Jun 14; 65(6):1073-82. PMID: 1828394.
    Citations: 140     Fields:    Translation:Cells
  48. Oh SJ, Chittenden T, Levine AJ. Identification of cellular factors that bind specifically to the Epstein-Barr virus origin of DNA replication. J Virol. 1991 Jan; 65(1):514-9. PMID: 1845905; PMCID: PMC240549.
    Citations: 6     Fields:    Translation:HumansCells
  49. Chittenden T, Livingston DM, Kaelin WG. RB associates with an E2F-like, sequence-specific DNA-binding protein. Cold Spring Harb Symp Quant Biol. 1991; 56:187-95. PMID: 1819485.
    Citations: 8     Fields:    Translation:HumansCells
  50. Chittenden T, Lupton S, Levine AJ. Functional limits of oriP, the Epstein-Barr virus plasmid origin of replication. J Virol. 1989 Jul; 63(7):3016-25. PMID: 2542609; PMCID: PMC250856.
    Citations: 35     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.