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Vasily Belov, Ph.D.

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Biography
2010
Poster of Excellence Award, MGH
2012
Outstanding Pharmaceutical Paper Award, Controlled Release Society
2016
First Place Poster, Society of Nuclear Medicine and Molecular Imaging
2016
First Place Award, 23rd Napa Pain Conference

Overview
Dr. Belov's present research relates to the investigation of the promising and therapeutically effective routes for delivery of macromolecular drugs to the central nervous system (CNS). Through years of investigational efforts, he and his colleagues were able to demonstrate that cerebrospinal fluid (CSF) can be used for drug administration resulting in high brain penetration. Now, he's focusing on studying biophysical aspects of drug transport in the CSF, developing approaches to enhance retention of drugs in the CSF, and unveiling conduits connecting CSF and brain parenchyma.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. (Vasily Belov) Dec 1, 2014 - Nov 30, 2015
    MGH ECOR
    Size dependent mechanisms of drug clearance from the cerebrospinal fluid
    Role Description: The goal of this study is to develop biophysical approaches for increasing the exposure of the central nervous system and meninges to drugs dissolved in the cerebrospinal fluid.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Belov V, Appleton J, Levin S, Giffenig P, Durcanova B, Papisov M. Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications. Front Neurosci. 2021; 15:604197. PMID: 33935624.
    Citations:    
  2. Shao T, Chen Z, Belov V, Wang X, Rwema SH, Kumar V, Fu H, Deng X, Rong J, Yu Q, Lang L, Lin W, Josephson L, Samir AE, Chen X, Chung RT, Liang SH. [18F]-Alfatide PET imaging of integrin avß3 for the non-invasive quantification of liver fibrosis. J Hepatol. 2020 07; 73(1):161-169. PMID: 32145257.
    Citations: 2     Fields:    
  3. Chen Z, Mori W, Fu H, Schafroth MA, Hatori A, Shao T, Zhang G, Van RS, Zhang Y, Hu K, Fujinaga M, Wang L, Belov V, Ogasawara D, Giffenig P, Deng X, Rong J, Yu Q, Zhang X, Papisov MI, Shao Y, Collier TL, Ma JA, Cravatt BF, Josephson L, Zhang MR, Liang SH. Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. J Med Chem. 2019 10 10; 62(19):8866-8872. PMID: 31518130.
    Citations: 5     Fields:    Translation:AnimalsCells
  4. Durcanova B, Appleton J, Gurijala N, Belov V, Giffenig P, Moeller E, Hogan M, Lee F, Papisov M. The Configuration of the Perivascular System Transporting Macromolecules in the CNS. Front Neurosci. 2019; 13:511. PMID: 31191221.
    Citations: 3     
  5. Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH. Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain. ACS Chem Neurosci. 2019 05 15; 10(5):2263-2275. PMID: 30698943.
    Citations: 1     Fields:    Translation:Animals
  6. Rotstein BH, Liang SH, Belov VV, Livni E, Levine DB, Bonab AA, Papisov MI, Perlis RH, Vasdev N. Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, a Calcium Channel Antagonist. Molecules. 2015 May 26; 20(6):9550-9. PMID: 26016546.
    Citations: 1     Fields:    Translation:Animals
  7. Golberg A, Khan S, Belov V, Quinn KP, Albadawi H, Felix Broelsch G, Watkins MT, Georgakoudi I, Papisov M, Mihm MC, Austen WG, Austen WG, Yarmush ML. Skin rejuvenation with non-invasive pulsed electric fields. Sci Rep. 2015 May 12; 5:10187. PMID: 25965851.
    Citations: 12     Fields:    Translation:AnimalsCells
  8. Ivanov AA, Abdrashitov GF, Anashin VV, Belchenko YI, Burdakov AV, Davydenko VI, Deichuli PP, Dimov GI, Dranichnikov AN, Kapitonov VA, Kolmogorov VV, Kondakov AA, Sanin AL, Shikhovtsev IV, Stupishin NV, Sorokin AV, Popov SS, Tiunov MA, Belov VP, Gorbovsky AI, Kobets VV, Binderbauer M, Putvinski S, Smirnov A, Sevier L. Development of a negative ion-based neutral beam injector in Novosibirsk. Rev Sci Instrum. 2014 Feb; 85(2):02B102. PMID: 24593542.
    Citations:    Fields:    
  9. Papisov MI, Belov VV, Gannon KS. Physiology of the intrathecal bolus: the leptomeningeal route for macromolecule and particle delivery to CNS. Mol Pharm. 2013 May 06; 10(5):1522-32. PMID: 23316936.
    Citations: 32     Fields:    Translation:HumansAnimals
  10. Papisov MI, Belov V, Belova E, Fischman AJ, Fisher R, Wright JL, Gannon KS, Titus J, Gagne M, Gillooly CA. Investigation of intrathecal transport of NPT002, a prospective therapeutic based on phage M13, in nonhuman primates. Drug Deliv Transl Res. 2012 Jun; 2(3):210-21. PMID: 25786868.
    Citations: 5     Fields:    
  11. Papisov MI, Belov V, Fischman AJ, Belova E, Titus J, Gagne M, Gillooly C. Delivery of proteins to CNS as seen and measured by positron emission tomography. Drug Deliv Transl Res. 2012 Jun; 2(3):201-9. PMID: 25786867.
    Citations: 11     Fields:    
  12. Palmina NP, Chasovskaya TE, Belov VV, Maltseva EL. Dose dependences of lipid microviscosity of biological membranes induced by synthetic antioxidant potassium phenosan salt. Dokl Biochem Biophys. 2012 Mar-Apr; 443:100-4. PMID: 22562635.
    Citations:    Fields:    Translation:AnimalsCells
  13. Calias P, Papisov M, Pan J, Savioli N, Belov V, Huang Y, Lotterhand J, Alessandrini M, Liu N, Fischman AJ, Powell JL, Heartlein MW. CNS penetration of intrathecal-lumbar idursulfase in the monkey, dog and mouse: implications for neurological outcomes of lysosomal storage disorder. PLoS One. 2012; 7(1):e30341. PMID: 22279584.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  14. Belov VV, Bonab AA, Fischman AJ, Heartlein M, Calias P, Papisov MI. Iodine-124 as a label for pharmacological PET imaging. Mol Pharm. 2011 Jun 06; 8(3):736-47. PMID: 21361362.
    Citations: 11     Fields:    Translation:HumansAnimals
  15. Belov VV, Mal'tseva EL, Pal'mina NP. [Modification of the structure of plasmatic membranes of the liver by the action of alpha-tocopherol in vitro]. Biofizika. 2011 Mar-Apr; 56(2):372-80. PMID: 21542368.
    Citations:    Fields:    Translation:AnimalsCells
  16. Belov VV, Mal'tseva EL, Pal'mina NP. [A study of the effect of low alpha-tocopherol concentrations on the dynamical parameters of microsomal membranes by the method of spin probes]. Biofizika. 2007 Jan-Feb; 52(1):75-83. PMID: 17348400.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Belov VV, Mal'tseva EL, Pal'mina NP, Burlakova EB. The role of solvent polarity in the mechanism of action of biologically active compounds at ultralow concentrations. Dokl Biochem Biophys. 2004 Nov-Dec; 399:362-4. PMID: 15714946.
    Citations:    Fields:    Translation:AnimalsCells
  18. Belov VV, Mal'tseva EL, Pal'mina NP. [The effect of alpha-tocopherol in a wide range of concentrations on the structural features of the lipid bilayer regions of endoplasmic reticulum membranes in the mouse liver cells in vitro]. Radiats Biol Radioecol. 2003 May-Jun; 43(3):306-9. PMID: 12881984.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.