Harvard Catalyst Profiles

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Taru E Muranen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA258372 (MURANEN, TARU ELIISA) Feb 1, 2021 - Jan 31, 2026
    Role of extracellular matrix proteins and tumor stroma in DNA repair and cancer progression
    Role: Principal Investigator
  2. R00CA180221 (MURANEN, TARU ELIISA) Aug 2, 2013 - Oct 31, 2019
    Mechanisms of extracellular matrix mediated drug resistance
    Role: Principal Investigator
  3. K99CA180221 (MURANEN, TARU ELIISA) Aug 2, 2013 - Jul 31, 2016
    Mechanisms of extracellular matrix mediated drug resistance
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Muranen T, Iwanicki MP, Curry NL, Hwang J, DuBois CD, Coloff JL, Hitchcock DS, Clish CB, Brugge JS, Kalaany NY. Starved epithelial cells uptake extracellular matrix for survival. Nat Commun. 2017 01 10; 8:13989. PMID: 28071763.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  2. Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS. ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. Cancer Res. 2016 12 15; 76(24):7168-7180. PMID: 27913436; PMCID: PMC5161652.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  3. Muranen T, Meric-Bernstam F, Mills GB. Promising rationally derived combination therapy with PI3K and CDK4/6 inhibitors. Cancer Cell. 2014 Jul 14; 26(1):7-9. PMID: 25026206.
    Citations: 3     Fields:    Translation:HumansAnimals
  4. Muranen T. Cell-cell and cell-matrix interactions. Mol Biol Cell. 2013 Mar; 24(6):671. PMID: 23486395.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Laulajainen M, Melikova M, Muranen T, Carpén O, Grönholm M. Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity. J Cell Mol Med. 2012 Sep; 16(9):2161-75. PMID: 22325036.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  6. Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012 Feb 14; 21(2):227-39. PMID: 22340595; PMCID: PMC3297962.
    Citations: 212     Fields:    Translation:HumansAnimalsCells
  7. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31; 43(9):869-74. PMID: 21804546.
    Citations: 508     Fields:    Translation:HumansCells
  8. Laulajainen M, Muranen T, Nyman TA, Carpén O, Grönholm M. Multistep phosphorylation by oncogenic kinases enhances the degradation of the NF2 tumor suppressor merlin. Neoplasia. 2011 Jul; 13(7):643-52. PMID: 21750658.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  9. Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince TA, Ince T, Brugge JS. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 2011 Jul; 1(2):144-57. PMID: 22303516.
    Citations: 146     Fields:    Translation:HumansCells
  10. Laulajainen M, Muranen T, Carpén O, Grönholm M. Protein kinase A-mediated phosphorylation of the NF2 tumor suppressor protein merlin at serine 10 affects the actin cytoskeleton. Oncogene. 2008 May 22; 27(23):3233-43. PMID: 18071304.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  11. Muranen T, Grönholm M, Lampin A, Lallemand D, Zhao F, Giovannini M, Carpén O. The tumor suppressor merlin interacts with microtubules and modulates Schwann cell microtubule cytoskeleton. Hum Mol Genet. 2007 Jul 15; 16(14):1742-51. PMID: 17566081.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  12. Grönholm M, Muranen T, Toby GG, Utermark T, Hanemann CO, Golemis EA, Carpén O. A functional association between merlin and HEI10, a cell cycle regulator. Oncogene. 2006 Jul 27; 25(32):4389-98. PMID: 16532029.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Muranen T, Grönholm M, Renkema GH, Carpén O. Cell cycle-dependent nucleocytoplasmic shuttling of the neurofibromatosis 2 tumour suppressor merlin. Oncogene. 2005 Feb 10; 24(7):1150-8. PMID: 15580288.
    Citations: 24     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.