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Lev T. Perelman, Ph.D.

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Biography
1997
Keynote Speaker, Gordon Research Conference
2000
AIP Top Ten Accomplishments in Biophysics for the Decade
2012
General Chair-Elect, OSA Biomedical Optics and 3-D Imaging Congress
2012
Emerging Frontiers in Research and Innovation Award
2014
Plenary Speaker, OSA Biomedical Optics and 3-D Imaging Congress
2017
BiOS Hot Topics Plenary Speaker

Overview
Three main research programs at the Center for Advanced Biomedical Imaging and Photonics are: 1) in vivo optical detection of preinvasive cancer; 2) studying sub-cellular morphology with confocal light absorption and scattering spectroscopic microscopy and 3) development of optical spectroscopic technique for noninvasive prenatal diagnosis. The Center develops and uses a variety of different tools and platforms for in vivo optical biomedical imaging.

In Vivo Optical Detection of Preinvasive Cancer

The purpose of this program is to develop an optical system which can perform rapid optical scanning and multispectral imaging of the entire epithelial surface of various organs in reproductive and gastrointestinal tracts and present a diagnosis in near real time. This approach is vastly superior to the present strategies of performing random biopsies. Thus, it can provide a powerful tool for screening large populations of patients for early precancerous changes. In its pilot clinical test in the esophagus at BIDMC this instrument, for the first time in the world, successfully guided biopsy detecting and mapping sites of invisible dysplasia missed by the current standard-of-care.

Studying Sub-Cellular Morphology with Confocal Light Absorption and Scattering Spectroscopic Microscopy

Confocal Light Absorption and Scattering Spectroscopic (CLASS) Microscopy developed at the Center is a novel way to use optical imaging techniques for non-invasive monitoring of embryonic cells on the submicron scale with no exogenous labels. The human embryo development and response to environmental factors could be monitored progressively at all critical stages using CLASS microscopy. For example, when cells are in metaphase, CLASS could provide information concerning the number and shape of chromosomes present. Since the CLASS measurement is nondestructive and requires no exogenous chemicals, a given embryo in vitro could be monitored over time before implantation. These kinds of progression studies are not possible with any other currently available techniques.

Optical Spectroscopic Technique for Noninvasive Prenatal Diagnosis

Non-invasive prenatal diagnosis utilizing fetal cells circulating in maternal peripheral blood has received much attention since it poses no risk to the fetus. Although several fetal cell types have been targeted, the search has focused on fetal nucleated red blood cells (fNRBC). Because of the low concentration of fNRBC in maternal blood, and interference by adult nucleated red blood cells (aNRBC), along with the failure to find broadly applicable identifiers that can differentiate fetal from aNRBC, reliable use of viable fNRBC in amounts sufficient for clinical use remains a challenge. We have demonstrated that fNRBC optical properties provide a unique optical biomarker that is based on the light scattering spectroscopic signatures of fNRBC and may enable isolation of these cells from maternal peripheral blood samples. This project can lead to development of a clinical minimally invasive prenatal genetic testing technique.

References:

Backman V, Wallace M, Perelman LT, et al. Detection of Preinvasive Cancer Cells. Early-Warning Changes in Precancerous Epithelial Cells Can Now be Spotted In Situ. Nature, 2000;406,6791:35-36.

Gurjar R, Backman V, Perelman LT, et al. Functional Imaging of Epithelial Tissues with Polarized Light Scattering Spectroscopy. Nature Medicine, 2001;7:1245-48.

Itzkan I, Qui L, Fang H, Zaman MM, Vitkin E, Ghiran IC, Salahuddin S, Modell MD, Andersson C, Kimerer LM, Cipolloni PB, Lim K-H, Bigio IJ, Itzkan I, Freedman SD, Sachs BP, Hanlon EB, & Perelman LT, Confocal Light Absorption & Scattering Spectroscopic (CLASS) Microscopy Monitors Organelles in Live Cells with no Exogenous Labels, Proc. Nat. Acad. Sci. USA, 2007; 104: 17255-17260.

Qiu L, Pleskow D, Chuttani R, Vitkin E, Leyden J, Ozden N, Itani S, Guo L, Sacks A, Goldsmith JD, Modell MD, Hanlon EB, Itzkan I, & Perelman LT. Multispectral Scanning during Endoscopy Guides Biopsy of Dysplasia in Barrett’s Esophagus, Nature Medicine, 2010; 16:603-606.

Vitkin E, Turzhitsky V, Qiu L, Guo L, Itzkan I, Hanlon EB, & Perelman LT. Photon diffusion near the point-of-entry in anisotropically scattering turbid media. Nature Commun. 2011; 2:587.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA228029 (PERELMAN, LEV T) Sep 1, 2018 - Aug 31, 2023
    NIH/NCI
    Spectro-Holographic Instrument for Dynamic Sensing of Cancer Progression
    Role: Principal Investigator
  2. R01CA218382 (PERELMAN, LEV T) Feb 1, 2018 - Jan 31, 2023
    NIH/NCI
    Isolation and Assessment of Blood-Circulating Cancer Exosomes with LSS and SERS Lab on a Chip Optical Spectroscopic Instrument
    Role: Principal Investigator
  3. R01EB025173 (PERELMAN, LEV T) Sep 30, 2017 - Aug 31, 2021
    NIH/NIBIB
    Endoscopic Fine-Needle Polarized Scanning Spectroscopy for Pancreatic Cystic Lesions Diagnosis
    Role: Principal Investigator
  4. CBET-1605116 (PERELMAN, LEV T) Jul 1, 2016 - Jun 30, 2019
    NSF
    Early Non-Invasive Diagnosis of Liver Disease with Optical Spectroscopy
    Role: Principal Investigator
  5. R01CA205431 (PERELMAN, LEV T) May 16, 2016 - Apr 30, 2021
    NIH/NCI
    (PQ7) In Vivo Cellular Optical Imaging of Esophageal Tumors and Microenvironment
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Turzhitsky V, Zhang L, Horowitz GL, Vitkin E, Khan U, Zakharov Y, Qiu L, Itzkan I, Perelman LT. Picoanalysis of Drugs in Biofluids with Quantitative Label-Free Surface-Enhanced Raman Spectroscopy. Small. 2018 Nov; 14(47):e1802392. PMID: 30369072.
    Citations:    Fields:    
  2. Qiu L, Chuttani R, Pleskow DK, Turzhitsky V, Khan U, Zakharov YN, Zhang L, Berzin TM, Yee EU, Sawhney MS, Li Y, Vitkin E, Goldsmith JD, Itzkan I, Perelman LT. Multispectral light scattering endoscopic imaging of esophageal precancer. Light Sci Appl. 2018; 7:17174. PMID: 30839534.
    Citations:    
  3. Zhang L, Pleskow DK, Yee EU, Berzin TM, Turzhitsky V, Vitkin E, Zakharov Y, Khan U, Wang F, Sawhney M, Goldsmith JD, Chuttani R, Itzkan I, Qiu L, Perelman LT. Light scattering spectroscopy identifies malignant potential of pancreatic cysts during endoscopy. Nature Biomed. Eng. 2017; 1:40.
  4. Zhang L, Pleskow DK, Turzhitsky V, Yee EU, Berzin TM, Sawhney M, Shinagare S, Vitkin E, Zakharov Y, Khan U, Wang F, Goldsmith JD, Goldberg S, Chuttani R, Itzkan I, Qiu L, Perelman LT. Light scattering spectroscopy identifies the malignant potential of pancreatic cysts during endoscopy. Nat Biomed Eng. 2017; 1. PMID: 29057146.
    Citations: 2     
  5. Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell. 2014 Nov 10; 26(5):707-21. PMID: 25446899.
    Citations: 246     Fields:    Translation:HumansAnimalsCells
  6. Beskorovaynyy AV, Kopitsyn DS, Novikov AA, Ziangirova M, Skorikova GS, Kotelev MS, Gushchin PA, Ivanov EV, Getmansky MD, Itzkan I, Muradov AV, Vinokurov VA, Perelman LT. Rapid optimization of metal nanoparticle surface modification with high-throughput gel electrophoresis. ACS Nano. 2014 Feb 25; 8(2):1449-56. PMID: 24392839.
    Citations:    Fields:    
  7. Turzhitsky V, Qiu L, Itzkan I, Novikov AA, Kotelev MS, Getmanskiy M, Vinokurov VA, Muradov AV, Perelman LT. Spectroscopy of scattered light for the characterization of micro and nanoscale objects in biology and medicine. Appl Spectrosc. 2014; 68(2):133-54. PMID: 24480270.
    Citations: 1     Fields:    
  8. Qiu L, Turzhitsky V, Chuttani R, Pleskow D, Goldsmith JD, Guo L, Vitkin E, Itzkan I, Hanlon EB, Perelman LT. Spectral Imaging with Scattered Light: From Early Cancer Detection to Cell Biology. IEEE J Sel Top Quantum Electron. 2012 May; 18(3):1073-1083. PMID: 23087592.
    Citations: 7     
  9. Vitkin E, Turzhitsky V, Qiu L, Guo L, Itzkan I, Hanlon EB, Perelman LT. Photon diffusion near the point-of-entry in anisotropically scattering turbid media. Nat Commun. 2011 Dec 13; 2:587. PMID: 22158442.
    Citations: 10     Fields:    Translation:HumansCells
  10. Qiu L, Turzhitsky V, Guo L, Vitkin E, Itzkan I, Hanlon EB, Perelman LT. Early Cancer Detection with Scanning Light Scattering Spectroscopy. IEEE J. Sel. Top. Quant. Elect. 2011; 99:1-11.
  11. Bastu E, Qui L, Vitkin E, Guo, L, Itzkan I, Perelman LT, Yeh J. Detecting Effects of Cisplatin on Ovarian Tissue by Optical Spectroscopy. Reproductive Sciences. 2011; 3(18):371A.
  12. Qiu L, Itzkan I, Perelman LT. Light Scattering Spectroscopy. In: Boas DA, Pitris C, Ramanujam N, editors. Handbook Of Biomedical Optics. Taylor & Francis Group. 2011.
  13. Qiu L, Vitkin E, Guo L, Hanlon EB, Itzkan I, Perelman LT. Differential spectral imaging with gold nanorod light scattering labels. Proc. SPIE. 2011; 7945:2E.
  14. Qiu L, Larson TA, Vitkin E, Guo L, Hanlon EB, Itzkan I, Sokolov KV, Perelman LT. Gold nanorod light scattering labels for biomedical imaging. Biomed Opt Express. 2010 Jul 15; 1(1):135-142. PMID: 21258453.
    Citations: 2     
  15. Qiu L, Pleskow DK, Chuttani R, Vitkin E, Leyden J, Ozden N, Itani S, Guo L, Sacks A, Goldsmith JD, Modell MD, Hanlon EB, Itzkan I, Perelman LT. Multispectral scanning during endoscopy guides biopsy of dysplasia in Barrett's esophagus. Nat Med. 2010 May; 16(5):603-6, 1p following 606. PMID: 20383155.
    Citations: 41     Fields:    Translation:Humans
  16. Hielscher AH, Mycek M-A, Perelman LT. Introduction: Feature Issue on Optical Imaging and Spectroscopy. Biomed. Opt. Express. 2010; 1:1244-1246.
  17. Qiu L, Pleskow D, Chuttani R, Vitkin E, Itani S, Guo L, Goldsmith J, Modell MD, Itzkan I, Hanlon EB, Perelman LT. Endoscopic Polarized Scanning Spectroscopic Imaging of Barrett’s Esophagus in vivo. Biomedical Optics, OSA Technical Digest. 2010; BMB4.
  18. Qiu L, Pleskow D, Chuttani R, Vitkin E, Leyden J, Ozden N, Itani S, Sacks A, Goldsmith J, Modell MD, Hanlon EB, Itzkan I, Perelman LT. Detection of dysplasia in Barrett’s esophagus with endoscopic polarized spectroscopic scanning (EPSS) instrument. Biomedical Applications of Light Scattering, Backman V and Wax A, editors, SPIE Press. 2010; 7535:25.
  19. Lim KH, Salahuddin S, Qiu L, Fang H, Vitkin E, Ghiran IC, Modell MD, Takoudes T, Itzkan I, Hanlon EB, Sachs BP, Perelman LT. Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis. Opt Lett. 2009 May 01; 34(9):1483-5. PMID: 19412313.
    Citations: 1     Fields:    Translation:HumansCells
  20. Perelman LT. Light Scattering. In: Yoshizawa T, editor. Handbook of Optical Metrology: Principles and Applications. Taylor & Francis Group. 2009; 321-338.
  21. Qiu L, Itzkan I, Perelman LT. Light Absorption And Scattering Spectroscopic Microscopy. In: Backman V, Wax A, editors. Biomedical Applications of Light Scattering. McGraw-Hill. 2009; 143-167.
  22. Perelman LT, Backman V. Light Scattering Spectroscopy of Epithelial Tissues: Principles and Applications. In: Tuchin V, editor. Handbook of Optical Biomedical Diagnostics. Second Edition, Bellingham: SPIE Press. 2009.
  23. Qiu L, Perelman LT. Confocal Light Absorption and Scattering Spectroscopic Microscopy. In: Tuchin V, editor. Handbook of Photonics for Biomedical Science. Taylor & Francis Group. 2009; 403-421.
  24. Qiu L, Chuttani R, Zhang S, Feng J, Itani S, Fang H, Pleskow D, Sawhney MS, Salahuddin S, Modell MD, Vitkin E, Hanlon EB, Itzkan I, Perelman LT. Diagnostic imaging of esophageal epithelium with clinical endoscopic polarized scanning spectroscopy instrument. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:1997-2000. PMID: 19964032.
    Citations: 1     Fields:    Translation:HumansCells
  25. Hanlon EB, Perelman LT, Vitkin EI, Greco FA, McKee AC, Kowall NW. Scattering differentiates Alzheimer disease in vitro. Opt Lett. 2008 Mar 15; 33(6):624-6. PMID: 18347731.
    Citations: 3     Fields:    Translation:HumansCells
  26. Qiu L, Vitkin E, Salahuddin S, Zaman M, Andersson S, Freedman SD, Hanlon EB, Itzkan I, Perelman LT. Confocal light scattering and absorption spectroscopic microscopy. Biophotonics: Photonic Solutions for Better Health Care, Popp J, Drexler W, Tuchin VV and Matthews DL, editors. SPIE Press. 2008; 6991.
  27. Qiu L, Larson TA, Smith DK, Vitkin E, Modell MD, Korgel BA, Sokolov KV, Hanlon EB, Itzkan I, Perelman LT. Observation of Plasmon Line Broadening in Single Gold Nanorods. Appl. Phys. Lett. 2008; 93:153106-1-4.
  28. Modell MD, Ryabukho V, Lyakin D, Lychagov V, Vitkin E, Itzkan I, Perelman LT. Autocorrelation Low Coherence Interferometry, Opt. Com. Opt. Com. 2008; 281:1991-1996.
  29. Itzkan I, Qiu L, Fang H, Zaman MM, Vitkin E, Ghiran IC, Salahuddin S, Modell M, Andersson C, Kimerer LM, Cipolloni PB, Lim KH, Freedman SD, Bigio I, Sachs BP, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy monitors organelles in live cells with no exogenous labels. Proc Natl Acad Sci U S A. 2007 Oct 30; 104(44):17255-60. PMID: 17956980.
    Citations: 35     Fields:    Translation:HumansCells
  30. Fang H, Qiu L, Vitkin E, Zaman MM, Andersson C, Salahuddin S, Kimerer LM, Cipolloni PB, Modell MD, Turner BS, Keates SE, Bigio I, Itzkan I, Freedman SD, Bansil R, Hanlon EB, Perelman LT. Confocal light absorption and scattering spectroscopic microscopy. Appl Opt. 2007 Apr 01; 46(10):1760-9. PMID: 17356619.
    Citations: 13     Fields:    
  31. Qiu L, Larson TA, Smith DK, Vitkin E, Zhang S, Modell MD, Hanlon EB, Itzkan I, Korgel BA, Sokolov KV, Perelman LT. Single Gold Nanorod Detection using Confocal Light Absorption and Scattering Spectroscopy. IEEE J. Sel. Top. Quant. Elect. 2007; 13:1730-1738.
  32. Perelman LT. Optical diagnostic technology based on light scattering spectroscopy for early cancer detection. Expert Rev Med Devices. 2006 Nov; 3(6):787-803. PMID: 17280544.
    Citations: 11     Fields:    Translation:Humans
  33. Modell MD, Perelman LT. Fiber Optics in Medicine. In: Webster JG, editor. Encyclopedia of Medical Devices and Instrumentation, Second Edition, John Wiley & Sons, Inc. 2006; 301-315.
  34. Schuele G, Vitkin E, Huie P, O'Connell-Rodwell C, Palanker D, Perelman LT. Optical spectroscopy noninvasively monitors response of organelles to cellular stress. J Biomed Opt. 2005 Sep-Oct; 10(5):051404. PMID: 16292941.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Schuele G, Molnar FE, Yellachich D, Vitkin E, Perelman LT, Palanker D. Non-invasive optical monitoring of choroidal reaction to retinal laser therapy. Invest. Ophthalmol. Vis. Sci. 2005; 46:3924.
  36. Gorbach A, Ntziachristos V, Perelman LT. Chapter 18. Advances in Optical Imaging of Cancer. In: Padhani AR and Choyke PL, editors. New Techniques in Oncologic Imaging. Taylor & Francis Group. 2005; 351-370.
  37. Hanlon EB, Siwek DF, Mckee AC, Kowall NW, Fang H, Vitkin E, Perelman LT. Optical spectroscopy to diagnose Alzheimer's disease in vivo. Biomedical Optical Spectroscopy and Diagnostics. Trends in Optics and Photonics Series. 2004; WC1.
  38. Perelman LT, Modell MD, Vitkin EI, Hanlon EB. Chapter 9. Light Scattering Spectroscopy: From Elastic to Inelastic. In: Tuchin V, editor. Coherent-Domain Optical Methods for Biomedical Diagnostics, Environmental and Material Science. Bristol and Philadelphia: Institute of Physics Publishing. 2004; 355-396.
  39. Fang H, Vitkin E, Ollero M, Itzkan I, Hanlon EB, Perelman LT. Light scattering spectroscopy for measuring subcellular organelles. Biomedical Optical Spectroscopy and Diagnostics. Trends in Optics and Photonics Series. 2004; FF3.
  40. Schuele G, Huie P, Vankov A, Vitkin E, Fang H, Hanlon EB, Perelman LT, Palanker D. Non-invasive Monitoring of the Thermal Stress in RPE Using Light Scattering Spectroscopy. Ophthalmic Technologies. 2004; 5314:1-5.
  41. Fang H, Ollero M, Vitkin E, Kimerer LM, Cipolloni PB, Zaman MM, Freedman SD, Bigio IJ, Itzkan I, Hanlon EB, Perelman LT. Noninvasive Sizing of Subcellular Organelles with Light Scattering Spectroscopy. IEEE J. Sel. Top. Quant. Elect. 2003; 9:267-276.
  42. Anderson RR, de Boer J, Jacques SL, Perelman LT, Rajadhyaksha M, Tromberg B. Optical Diagnostic Imaging Workshop. Las. Surg. Med. 2003; 32:246.
  43. Hanlon EB, Vitkin EI, Perelman LT. Light Scattering Spectroscopy Detects Changes in Alzheimer’s Brain. Biomedical Optical Spectroscopy and Diagnostics. Trends in Optics and Photonics Series. 2002; 22:387-389.
  44. Perelman LT, Backman V. Chapter 12. Light Scattering Spectroscopy of Epithelial Tissues: Principles and Applications. In: Tuchin V, editor. Handbook of Optical Biomedical Diagnostics. Bellingham: SPIE Press. 2002; 675-724.
  45. Backman V, Gurjar R, Perelman LT, Gopal V, Kalashnikov M, Badizadegan K, Wax A, Georgakoudi I, Mueller M, Boone CW, Itzkan I, Dasari RR, Feld MS. Imaging and Measurement of Cell Structure and Organization with Submicron Accuracy using Light Scattering Spectroscopy. Optical Biopsy. 2002; 4613:101-110.
  46. Gurjar RS, Backman V, Perelman LT, Georgakoudi I, Badizadegan K, Itzkan I, Dasari RR, Feld MS. Imaging human epithelial properties with polarized light-scattering spectroscopy. Nat Med. 2001 Nov; 7(11):1245-8. PMID: 11689891.
    Citations: 43     Fields:    Translation:HumansCells
  47. Georgakoudi I, Jacobson BC, Van Dam J, Backman V, Wallace MB, Müller MG, Zhang Q, Badizadegan K, Sun D, Thomas GA, Perelman LT, Feld MS. Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus. Gastroenterology. 2001 Jun; 120(7):1620-9. PMID: 11375944.
    Citations: 66     Fields:    Translation:HumansCells
  48. Backman V, Wallace M, Perelman LT, Arendt J, Gurjar R, Muller MG, Zhang Q, Zonios G, Kline E, McGillican T, Valdez T, Van Dam J, Badizadegan K, Crawford JM, Fitzmaurice M, Kabani S, Levin HS, Seiler M, Dasari RR, Itzkan I, Feld MS. Light Scattering Spectroscopy: A New Technique for Clinical Diagnosis of Precancerous and Cancerous Changes in Human Epithelia. Las. Life Sci. 2001; 9:255-263.
  49. Kneipp K, Perelman LT, Kneipp H, Backman V, Jorio A, Dresselhaus G, Dresselhaus MS. Coupling and Intensity Exchange Between Phonon Modes Observed in Strongly Enhanced Raman Spectra of Single-Wall Carbon Nanotubes on Silver Colloidal Clusters. Phys. Rev. B. 2001; 63:193411-1-4..
  50. Wallace MB, Perelman LT, Backman V, Crawford JM, Fitzmaurice M, Seiler M, Badizadegan K, Shields SJ, Itzkan I, Dasari RR, Van Dam J, Feld MS. Endoscopic detection of dysplasia in patients with Barrett's esophagus using light-scattering spectroscopy. Gastroenterology. 2000 Sep; 119(3):677-82. PMID: 10982761.
    Citations: 49     Fields:    Translation:Humans
  51. Backman V, Wallace MB, Perelman LT, Arendt JT, Gurjar R, Müller MG, Zhang Q, Zonios G, Kline E, McGilligan JA, Shapshay S, Valdez T, Badizadegan K, Crawford JM, Fitzmaurice M, Kabani S, Levin HS, Seiler M, Dasari RR, Itzkan I, Van Dam J, Feld MS, McGillican T. Detection of preinvasive cancer cells. Nature. 2000 Jul 06; 406(6791):35-6. PMID: 10894529.
    Citations: 71     Fields:    Translation:HumansCells
  52. Kneipp K, Kneipp H, Corio P, Brown SD, Shafer K, Motz J, Perelman LT, Hanlon EB, Marucci A, Dresselhaus G, Dresselhaus MS. Surface-enhanced and normal stokes and anti-stokes Raman spectroscopy of single-walled carbon nanotubes. Phys Rev Lett. 2000 Apr 10; 84(15):3470-3. PMID: 11019117.
    Citations: 4     Fields:    
  53. Yang C, Perelman LT, Wax A, Dasari RR, Feld MS. Feasibility of field-based light scattering spectroscopy. J Biomed Opt. 2000 Apr; 5(2):138-43. PMID: 10938777.
    Citations: 4     Fields:    Translation:Cells
  54. Chen K, Perelman LT, Zhang Q, Dasari RR, Feld MS. Optical computed tomography in a turbid medium using early arriving photons. J Biomed Opt. 2000 Apr; 5(2):144-54. PMID: 10938778.
    Citations: 7     Fields:    
  55. Dark ML, Perelman LT, Itzkan I, Schaffer JL, Field MS. Physical properties of hydrated tissue determined by surface interferometry of laser-induced thermoelastic deformation. Phys Med Biol. 2000 Feb; 45(2):529-39. PMID: 10701519.
    Citations: 2     Fields:    Translation:Humans
  56. Chen K, Perelman LT, Feld MS. Seeing Through the Human Body: Diagnostic Optical Imaging of Deep Tissue. The Spectrograph. 2000; 17:2.
  57. Zonios G, Perelman LT, Backman V, Manoharan R, Fitzmaurice M, Van Dam J, Feld MS. Diffuse reflectance spectroscopy of human adenomatous colon polyps in vivo. Appl Opt. 1999 Nov 01; 38(31):6628-37. PMID: 18324198.
    Citations: 88     Fields:    
  58. Yang C, An K, Perelman LT, Dasari RR, Feld MS. Spatial coherence of forward-scattered light in a turbid medium. J Opt Soc Am A Opt Image Sci Vis. 1999 Apr; 16(4):866-71. PMID: 10192961.
    Citations: 1     Fields:    
  59. Fitzmaurice M, Wallace M, Perelman LT, Backman V, Crawford JM, Seiler M, Badizadegan K, Shields SJ, Itzkan I, Dasari R, Van Dam J, Feld MS. Endoscopic Diagnosis of Dysplasia in Barrett’s Esophagus (BE): A Novel Light Scattering-Reflectance Spectroscopy Technique. Lab. Invest. 1999; 79:428.
  60. Dark ML, Perelman LT, Itzkan I, Schaffer JL, Feld MS. Laser-Induced Stress Waves in Soft Tissue: Thermoelastic and Cavitation Effects. In: American Physical Society Centennial Meeting. 1999.
  61. Fitzmaurice M, Wallace MB, Perelman LT, Backman V, Crawford JM, Seiler M, Badizadegan K, Shields SJ, Itzkan I, Dasari R, Van Dam J, Feld MS. Endoscopic Diagnosis of Dysplasia in Barrett’s Esophagus. Modern Pathology. 1999; 12:75.
  62. Backman V, Gurjar R, Badizadegan K, Zonios G, Itzkan I, Dasari RR, Crawford JM, Van Dam J, Perelman LT, Feld MS. Light Scattering Spectroscopy for Early Cancer Diagnosis. Laser Spectroscopy. 1999; 286-295.
  63. Perelman LT, Zonios G, Backman V, Gurjar R, Itzkan I, Dasari RR, Van Dam J, Feld MS. Quantitative Analysis of Mucosal Tissues in Patients Using Light Scattering Spectroscopy. In: Alfano RR, Chance B, Tromberg BJ, editors. Optical Tomography and Spectroscopy of Tissue. SPIE Press. 1999; 3597:474-479.
  64. Backman V, Gurjar R, Badizadegan K, Dasari RR, Itzkan I, Perelman LT, Feld MS. 1999; 5:1019-27. Polarized Light Scattering Spectroscopy for Quantitative Measurement of Epithelial Cellular Structures In Situ. IEEE J. Sel. Top. Quant. Elect. 1999; 5:1019-1027.
  65. Wallace M, Perelman LT, Crawford JM, Fitzmaurice M, Seiler M, Badizadegan K, Shields S, Itzkan I, Dasari RR, Van Dam J, Feld MS. Research Report on Endoscopic Detection of Dysplasia in Patients With Barrett's Esophagus Using Light Scattering Spectroscopy: A Prospective Study. The Spectrograph. 1999; 15:2.
  66. Winn JN, Perelman LT, Chen K, Wu J, Dasari RR, Feld MS. Distribution of the paths of early-arriving photons traversing a turbid medium. Appl Opt. 1998 Dec 01; 37(34):8085-91. PMID: 18301702.
    Citations:    Fields:    
  67. Perelman LT. Measurement of Nuclear Size Distribution of Epithelial Tissues In Vivo for Diagnosis of Early Precancerous Changes Using Reflectance Spectroscopy. In: Technical Digest. Summaries of Papers Presented at the Conference on Lasers and Electro-Optics. Conference Edition. 1998; 6:87.
  68. Perelman LT, Winn JN, Chen K, Dasari RR, Feld MS. Density of Photon Paths in Turbid Medium for Short Times of Flight. In: Proceedings of the Conference on Advances in Optical Imaging and Photon Migration. 1998.
  69. Manoharan R, Shafer K, Perelman L, Wu J, Chen K, Deinum G, Fitzmaurice M, Myles J, Crowe J, Dasari RR, Feld MS. Raman spectroscopy and fluorescence photon migration for breast cancer diagnosis and imaging. Photochem Photobiol. 1998 Jan; 67(1):15-22. PMID: 9477761.
    Citations: 19     Fields:    Translation:Humans
  70. Perelman LT, Zonios G, Backman V, Manoharan R, Fitzmaurice M, Feld MS. Reflectance Spectroscopy for Quantitative Analysis of Mucosal Tissue In Vivo: Method to Detect Early Precancerous Changes. In: OSA Annual Meeting. 1998.
  71. Wallace MB, Shields SJ, Perelman LT, Backman V, Zonios G, Manoharan R, Badizadegan K, Nusrat A, Seiler M, Hamano T, Itzkan I, Lima C, Fitzmaurice M, Crawford JM, Van Dam J, Feld MS. Fiber-optic Detection of Low-grade Dysplasia in patients with Barrett’s Esophagus Using reflectance Spectroscopy. Gastroenterology. 1998; 114:A327.
  72. Perelman LT, Chen K, Dasari RR, Feld MS. Localization of fluorescent objects imbedded in turbid media in the presence of background fluorescence. Advances in Optical Imaging and Photon Migration, J. Fujimoto and M. Patterson, editors. OSA Trends in Optics and Photonics. 1998; 21:AWC3.
  73. Perelman LT, Backman V, Wallace M, Zonios G, Manoharan R, Nusrat A, Shields S, Seiler M, Lima C, Hamano T, Itzkan I, Van Dam J, Crawford JM, Feld MS. Observation of Periodic Fine Structure in Reflectance from Biological Tissue: A New Technique for Measuring Nuclear Size Distribution. Phys. Rev. Lett. 1998; 80:627-630.
  74. Wu J, Perelman L, Dasari RR, Feld MS. Fluorescence tomographic imaging in turbid media using early-arriving photons and Laplace transforms. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8783-8. PMID: 9238055.
    Citations: 24     Fields:    Translation:HumansAnimals
  75. Perelman LT, Winn J, Wu J, Dasari RR, Feld MS. Photon migration of near-diffusive photons in turbid media: a Lagrangian-based approach. J Opt Soc Am A Opt Image Sci Vis. 1997 Jan; 14(1):224-9. PMID: 8988617.
    Citations:    Fields:    Translation:Cells
  76. Zonios G, VanDam J, Perelman LT, Backman V, Manoharan R, Feld MS. Quantitative Histological Analysis of Colonic Tissue using Diffuse Reflectance Spectroscopy at Colonoscopy. Gastrointestinal Endoscopy. 1997; 45:80.
  77. Marshall J, Hill C, Perelman LT, Adcroft A. Hydrostatic, Quasi-hydrostatic, and Nonhydrostatic Ocean Modeling. J. Geophys. Res. 1997; 102:5733-5752.
  78. Kneipp K, Wang Y, Kneipp H, Perelman LT, Itzkan I, Dasari RR, Feld MS. Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS). Phys. Rev. Lett. 1997; 78:1667-1670.
  79. Chen K, Perelman LT, Dasari RR, Feld MS. Optical Tomographic Imaging using Fluorescence Photon Migration. Proceedings of the ICOLS’97. 1997; 421-426.
  80. Marshall J, Adcroft A, Hill C, Perelman LT, Heisey C. A Finite-Volume, Incompressible Navier-Stokes Model for Studies of the Ocean on Parallel Computers. J. Geophys. Res. 1997; 102:5753-5766.
  81. Landenfield T, Marshall J, Perelman LT. Implementation of Topography in Ocean Models: a Shaved Cell Approach on an Unstaggered Grid. Finite Volumes for Complex Applications. 1996; 571-579.
  82. Wu J, Perelman LT, Dasari RR, Feld MS. Photon Paths in Turbid Media: From Smooth to Random. Advances in Optical Imaging and Photon Migration. Trends in Optics and Photonics Series. 1996; 2:116-118.
  83. Perelman LT, Wu J, Chen K, Itzkan I, Dasari RR, Feld MS. Tomographic Detection of Fluorophores Embedded in Tissue-Like Phantom. Advances in Optical Imaging and Photon Migration. Trends in Optics and Photonics Series. 1996; 2:18-20.
  84. Wu J, Wang Y, Perelman L, Itzkan I, Dasari RR, Feld MS. Three-dimensional imaging of objects embedded in turbid media with fluorescence and Raman spectroscopy. Appl Opt. 1995 Jun 20; 34(18):3425-30. PMID: 21052155.
    Citations: 3     Fields:    
  85. Perelman LT, Wu J, Wang Y, Itzkan I, Dasari RR, Feld MS. Time-dependent photon migration using path integrals. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 1995 Jun; 51(6):6134-6141. PMID: 9963353.
    Citations: 1     Fields:    
  86. Itzkan I, Albagli D, Dark ML, Perelman LT, von Rosenberg C, Feld MS. The thermoelastic basis of short pulsed laser ablation of biological tissue. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):1960-4. PMID: 7892208.
    Citations: 2     Fields:    Translation:HumansAnimals
  87. Wu J, Wang Y, Perelman L, Itzkan I, Dasari RR, Feld MS. Time-resolved multichannel imaging of fluorescent objects embedded in turbid media. Opt Lett. 1995 Mar 01; 20(5):489-91. PMID: 19859230.
    Citations: 4     Fields:    
  88. Wu J, Wang Y, Perelman LT, Itzkan I, Dasari RR, Feld MS. Time-Resolved 3-D Imaging of Fluorescent Objects in Turbid Media. Photon Transport in Highly Scattering Tissue. 1995; 252-258.
  89. Schaffer JL, Dark M, Itzkan I, Albagli D, Perelman L, von Rosenberg C, Feld MS. Mechanisms of meniscal tissue ablation by short pulse laser irradiation. Clin Orthop Relat Res. 1995 Jan; (310):30-6. PMID: 7641455.
    Citations: 2     Fields:    Translation:HumansAnimals
  90. Kneipp K, Wang Y, Kneipp H, Perelman LT, Itzkan I, Dasari RR, Feld MS. Experimentelle Technik der Physik. An Approach to Single Molecule Detection using Surface-Enhanced Raman Scattering (SERS). 1995; 41:225.
  91. Perelman LT, Albagli D, Dark M, Schaffer J, von Rosenberg C, Itzkan I, Feld MS. The Photomechanical Basis of Laser Ablation of Biological Tissue. roceedings on the Biomedical Optics. 1995; 316.
  92. Perelman LT, Wu J, Itzkan I, Wang Y, Dasari RR, Feld MS. Optical Imaging in Turbid Media using Early Arriving Photons. In: Proceedings on the Biomedical Optics. 1995.
  93. Wu J, Wang Y, Perelman LT, Itzkan I, Dasari RR, Feld MS. Time-Resolved 3-D Imaging of Fluorescent Objects in Turbid Media. Photon Transport in Highly Scattering Tissue. 1995; 252-258.
  94. Albagli D, Dark M, Perelman LT, von Rosenberg C, Itzkan I, Feld MS. Photomechanical basis of laser ablation of biological tissue. Opt Lett. 1994 Nov 01; 19(21):1684-6. PMID: 19855621.
    Citations: 2     Fields:    
  95. Albagli D, Dark M, von Rosenberg C, Perelman L, Itzkan I, Feld MS. Laser-induced thermoelastic deformation: a three-dimensional solution and its application to the ablation of biological tissue. Med Phys. 1994 Aug; 21(8):1323-31. PMID: 7799877.
    Citations: 4     Fields:    Translation:Animals
  96. Perelman LT, Wu J, Itzkan I, Feld MS. Photon migration in turbid media using path integrals. Phys Rev Lett. 1994 Feb 28; 72(9):1341-1344. PMID: 10056688.
    Citations: 1     Fields:    
  97. Perelman LT, Wu J, Itzkan I, Feld MS. Photon Migration in Turbid Media for Biomedical Imaging Using Feynman Path Integrals. The Spectrograph. 1994; 10:1-9.
  98. Perelman LT, Albagli D, Dark M, Schaffer JL, von Rosenberg C, Itzkan I, Feld MS. Physics of Laser-Induced Stress Wave Propagation, Cracking, and Cavitation in Biological Tissue. J. Soc. Photo-Opt. Instrum. Eng. 1994; 144-155.
  99. Albagli D, Banish B, Dark M, Janes GS, von Rosenberg C, Perelman L, Itzkan I, Feld MS. Interferometric surface monitoring of biological tissue to study inertially confined ablation. Lasers Surg Med. 1994; 14(4):374-85. PMID: 8078387.
    Citations: 5     Fields:    Translation:HumansAnimals
  100. Perelman LT, Wu J, Itzkan I, Wang Y, Dasari R, Feld MS. Photon paths in turbid media: theory and experimental observation. In: Alfano RR, editor. Advances in Optical Imaging and Photon Migration, Washington, DC: OSA. 1994; 153-155.
  101. Albagli D, Perelman LT, Janes GS, von Rosenberg C, Itzkan I, Feld MS. Inertially Confined Ablation of Biological Tissue. Las. Life Sci. 1994; 6:55-68.
  102. Hill C, Marshall J, Perelman LT. A New Ocean Circulation Model for ATOC. ATOC Occasional Notes. 1994; 20:1-5.
  103. Itzkan I, Albagli D, Banish BJ, Dark M, von Rosenberg C, Perelman LT, Janes GS, Feld MS. Pressure Generation During Inertially Confined Laser Ablation of Biological Tissue. In: Miller JC, Geohegan DB, editors. Proceedings of the 2nd International conference on Laser Ablation: Mechanisms and Applications (COLA’93), Knoxville, Tennessee: AIP Conference Proceedings. 1993; 288:491-506.
  104. Gaponenko SI, Malinovsky IE, Perelman LT, Zimin LG. Light Pulse Propagation Through ZnSe Monocrystals under Conditions of Excitonic Nonlinearity and Bistability. J. Luminescence. 1992; 52:225-231.
  105. Perelman LT, Vitkin EI. On the Multispike Structure of Transmitted Pulse in Monocrystalline Films with Absorption Bistability. Phys. Stat. Sol. B. 1991; 168:296-304.
  106. Vitkin EI, Eremin AV, Ziborov VS, Kirillov AI, Perelman LT. Non-Equilibrium Processes During Gas Jet Formation. Parts II. Minsk: IPAN BSSR. 1989; 36 p.
  107. Vitkin EI, Eremin AV, Ziborov VS, Kirillov AI, Perelman LT. Non-Equilibrium Processes During Gas Jet Formation. Parts I. Minsk: IPAN BSSR. 1989; 52 p.
  108. Anisimov SI, Karyagin VP, Konstantinov VA, Kudryashov VA, Lavrentev NN, Perelman LT, Ruzsov YuA, Svirshevsky SB, Strukov AE, Terterashvily AV, Fortov VE, Hatuncev AG. Studies of the Halley Comet Dust Atmosphere. VEGA Spacecraft Project. Moscow: MAI. 1987; 54 p.
  109. Vitkin EI, Perelman LT, Khodyko YV. Numerical Modeling of Supersonic Jet Two-Phase Flows with Pronounced Shock Waves. J. Eng. Phys. 1987; 53:32-36.
  110. Khodyko YV, Perelman LT. Two-Parameter Method of Summing Equivalent Spectral Linewidths in the Curtis-Godson Approximation. J. Eng. Phys. 1985; 6:1428-1433.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.