Shahzad Shaefi, M.B.,B.S.
Assistant Professor of Anaesthesia
Beth Israel Deaconess Medical Center
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston MA 02215
|Harvard T.H. Chan School of Public Health||MPH||2017||Clinical Effectiveness|
|University College London||MD||2001||Medicine|
The Shaefi lab research program is focused on translational and clinical research surrounding the protective effects of different admixtures of oxygen administered perioperatively, as well as prevention and treatment of Perioperative Neurocognitive Disorders following cardiac surgery. His laboratory and clinical focus include the following areas of interest
Preclinical Effects of Protective Hypoxia in Sepsis and Critical Illness Models
The Shaefi lab is investigating whether hypoxia could be beneficial and perhaps even necessary for attenuation of the inflammatory response in various disease states. Murine models of sepsis, trauma, subsequent critical illness and cardiac arrest are currently being utilized. A study of the effects of differing concentrations of oxygen and use of other gasotransmitters in a porcine cardiopulmonary bypass model is also underway.
Clinical Trials Regarding Titration of Oxygen and Use of Low Dose Carbon Monoxide
Dr. Shaefi has completed a randomized clinical trial examining the effect of different intraoperative oxygen concentrations and the effect on postoperative neurocognition in cardiac surgery. Additionally, Dr. Shaefi is involved in a clinical study in which he is assessing clinical outcome and changes in inflammatory signatures with administration of conservative vs conventional oxygen levels delivered to patients in the ICU. Furthermore, he is embarking upon work associated with the administration low-dose carbon monoxide. Carbon monoxide exerts its effects in part by binding to the same hemoproteins as oxygen, largely in the mitochondria. There is significant preclinical data that has been amassed regarding the anti-inflammatory, anti-apoptotic and antimicrobial effects of carbon monoxide. The lab is performing exploratory studies in healthy human volunteers with carbon monoxide exposure as a prelude to larger clinical trials in various surgical and critical illness settings. The demonstration of salutary effects of carbon monoxide in the perioperative space has far reaching and significant implications for the care of our patients.
Biomarker Discovery of Delirium in Cardiac Surgery
Dr. Shaefi has a long-standing interest in post-cardiac surgical delirium. His laboratory is examining proteomic signatures of patients exhibiting delirium after cardiac surgery. This proteomic analysis, together with advanced bioinformatics, has led to the potential identification of various candidate biomarker proteins of delirium after cardiac surgery. Ongoing prospective work will further examine and validate these biomarkers and assess the potential of regulating upstream and downstream signaling of pathways that involve these proteins.
Available: 01/01/20, Expires: 12/31/21
Carbon Monoxide (CO), long thought of as singularly harmful, shows promise as a wide-ranging therapeutic agent with anti-inflammatory, antimicrobial, and antiapoptotic properties. This bioactive gas, produced endogenously by the enzyme Heme Oxygenase-1, exerts cytoprotective effects in various disease states, and in settings of oxidative stress and inflammation. Cardiac Arrest is a disease state with poor long-term outcomes, due to the damaging effects of the subsequent neurological and cardiovascular dysfunction, and ischemia-reperfusion injury. Several studies have demonstrated the potential of CO to ameliorate ischemia reperfusion injury and resolve systemic inflammation, key factors in the poor outcomes following Cardiac Arrest, yet the role of CO in this arena has not formally been examined surprisingly.
We are interested in creating a preclinical murine model of Cardiac Arrest and assessing the effects of CO on the disease physiology and outcomes. The student in the proposed project will be exposed to the workings of small animal models as well as basic techniques of experimental design, execution and eventual publishing. We aim to carry the knowledge gained in these studies into larger animal models and eventually into human treatment. This project commitment could range from small summer focused project to a year plus commitment depending on student's interest and scope.
Available: 09/02/19, Expires: 12/31/21
Sepsis and Septic Shock, a severe subset of Sepsis characterized by circulatory and metabolic dysfunction, remains one of the leading causes of morbidity and mortality in the critically ill population, responsible for one out of every three hospital deaths, and exhibits a concerning upward trend in incidence. It remains frustratingly difficult to treat and requires novel therapeutic approaches, one of which may come by a rethinking of the first line of treatment, oxygenation. We posit that targeted titrations of oxygen could reduce the burden of oxidative stress placed on the body by conventionally higher oxygen therapy, activate several key cytoprotective pathways, and thus improve patient outcomes.
We aim to develop a Clinical Trial investigating the effect of varying oxygen titrations on Septic Shock patient outcomes. The student in this proposed trial would be closely involved with the development and execution of a large clinical trial, including gaining an understanding of human subjects research, patient screening, enrollment and consenting as well as grant writing, manuscript preparation and fundamentals of biostatistics and epidemiological research within clinical trials.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
(LEAF, DAVID EVAN)
Sep 1, 2020 - Jun 30, 2025
Deferoxamine for the Prevention of Acute Kidney Injury
Aug 1, 2019 - Jul 31, 2023
Sepsis and the benefits of permissive hypoxia
Role: Principal Investigator
Aug 1, 2018 - Jul 31, 2020
Proteomic Analysis of Postoperative Delirium from a randomized trial in Older Patients undergoing Cardiac Surgery exposed to Intraoperative Normoxia versus Hyperoxia: A Nested Case-Control Study
Role: Principal Investigator
Jan 1, 2016 - Dec 31, 2020
DAMP-Mediated Innate Immune Failure and Pneumonia after Trauma
Role Description: The goal of this Program Project Grant is to provide greater immunobiological understanding of the cellular and molecular mechanisms predisposing to infection
FAER Mentored Research Grant
Jan 1, 2016 - Dec 31, 2017
Foundation of Anesthesia Education and Research (FAER)
The relationship between administered oxygen levels and arterial partial oxygen pressure to neurocognition in cardiac surgical patients.
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