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Shahzad Shaefi, M.B.,B.S.

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Biography
Harvard T.H. Chan School of Public HealthMPH2017Clinical Effectiveness
University College LondonMD2001Medicine

Overview
The Shaefi lab research program is focused on translational and clinical research surrounding the protective effects of different admixtures of oxygen administered perioperatively, as well as prevention and treatment of Perioperative Neurocognitive Disorders following cardiac surgery. His laboratory and clinical focus include the following areas of interest

Preclinical Effects of Protective Hypoxia in Sepsis and Critical Illness Models
The Shaefi lab is investigating whether hypoxia could be beneficial and perhaps even necessary for attenuation of the inflammatory response in various disease states. Murine models of sepsis, trauma, subsequent critical illness and cardiac arrest are currently being utilized. A study of the effects of differing concentrations of oxygen and use of other gasotransmitters in a porcine cardiopulmonary bypass model is also underway.

Clinical Trials Regarding Titration of Oxygen and Use of Low Dose Carbon Monoxide
Dr. Shaefi has completed a randomized clinical trial examining the effect of different intraoperative oxygen concentrations and the effect on postoperative neurocognition in cardiac surgery. Additionally, Dr. Shaefi is involved in a clinical study in which he is assessing clinical outcome and changes in inflammatory signatures with administration of conservative vs conventional oxygen levels delivered to patients in the ICU. Furthermore, he is embarking upon work associated with the administration low-dose carbon monoxide. Carbon monoxide exerts its effects in part by binding to the same hemoproteins as oxygen, largely in the mitochondria. There is significant preclinical data that has been amassed regarding the anti-inflammatory, anti-apoptotic and antimicrobial effects of carbon monoxide. The lab is performing exploratory studies in healthy human volunteers with carbon monoxide exposure as a prelude to larger clinical trials in various surgical and critical illness settings. The demonstration of salutary effects of carbon monoxide in the perioperative space has far reaching and significant implications for the care of our patients.

Biomarker Discovery of Delirium in Cardiac Surgery
Dr. Shaefi has a long-standing interest in post-cardiac surgical delirium. His laboratory is examining proteomic signatures of patients exhibiting delirium after cardiac surgery. This proteomic analysis, together with advanced bioinformatics, has led to the potential identification of various candidate biomarker proteins of delirium after cardiac surgery. Ongoing prospective work will further examine and validate these biomarkers and assess the potential of regulating upstream and downstream signaling of pathways that involve these proteins.

Mentoring
Available: 04/05/22, Expires: 06/01/23

The Shaefi Lab, housed within the Department of Anesthesia, Critical Care and Pain Medicine at Beth Israel Deaconess Medical Center, focuses on translational and clinical areas of research that investigate the most appropriate perioperative administration and titration of oxygen. The use of oxygen is ubiquitous in clinical practice representing the most widely prescribed drug in the modern in-hospital setting. It is estimated that 15% patient admitted to the hospital and 95% of patients entering an intensive care unit or undergoing surgery receive supplemental oxygen. Overall 50 million people or one sixth of the United States population receives oxygen in these settings every year. Traditionally, anesthesiologists, critical care physicians and other clinicians have almost universally administered oxygen at higher than required levels in order to avoid potentially injurious levels of hypoxemia in their patients. There is mounting evidence that this stance of liberal administration and relative lack of titration of oxygen may not be as benign as first thought. Further, the clinical weight of evidence persuasively supports the finding that high levels of administered oxygen (hyperoxia) without endpoint titration confer more risk than benefit. Compelling preclinical evidence exists for the protective and regenerative aspects of low levels of oxygen (hypoxia) in specific settings. Significant efforts in the Shaefi lab are geared towards an understanding of the mechanisms of this protective hypoxia, especially in the setting of inflammation and sepsis through the use of preclinical models. Further work examining the beneficial role of hypoxia with human subjects in the clinical sphere are ongoing within the Shaefi lab. Admittedly, the concept of titrating hypoxic admixtures in acutely ill patients is fought with challenges. It would be ideal to impart the protective effects of hypoxic cellular exposure while avoiding the unforgiving repercussions of administering hypoxic admissions. Therefore, much of the work within the lab focuses on interventions to up regulate protective hypoxic properties under normoxic conditions, termed pseudo-hypoxia. Both small and large animal preclinical models are focused on developing this very palatable option for treatment, feasibility, safety and efficacy before moving this into human clinical interventional trials. There are various cytoprotective mechanisms activated during cellular stress. Heme Oxygenase-1 is one such mechanism, and is highly upregulated in periods of tissue hypoxia and sepsis. This stress response gene, regulated in part by hypoxia inducible factor, can metabolize heme to its metabolites biliverdin, iron and carbon monoxide. Although some of the mechanisms are unclear, the anti-inflammatory, antimicrobial and overall salutary effects of carbon monoxide have been well characterized in preclinical models. The translational aspect of investigations in the Shaefi lab aim to further delineate aspects of the mechanisms underlying the benefit observed with the administration of low dose exogenous carbon monoxide. Once these effects have been more fully elucidated in preclinical models, stepwise clinical observational and interventional studies will be performed in healthy subjects, patients undergoing major cardiac and noncardiac surgery as well as our vulnerable critically ill patient population


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK126685 (LEAF, DAVID EVAN) Jul 15, 2022 - Jul 14, 2027
    NIH/ NIDDK
    Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury
    Role: Co-Investigator
  2. R01DK125786 (LEAF, DAVID EVAN) Sep 1, 2020 - Jun 30, 2025
    NIH/ NIDDK
    Deferoxamine for the Prevention of Acute Kidney Injury
    Role: Co-Investigator
  3. K08GM134220 (SHAEFI, SHAHZAD) Aug 1, 2019 - Jul 31, 2023
    NIH
    Sepsis and the benefits of permissive hypoxia
    Role: Principal Investigator
  4. R03AG060179 (SHAEFI, SHAHZAD) Aug 1, 2018 - Apr 30, 2021
    NIH
    Proteomic Analysis of Postoperative Delirium from a randomized trial in Older Patients undergoing Cardiac Surgery exposed to Intraoperative Normoxia versus Hyperoxia: A Nested Case-Control Study
    Role: Principal Investigator
  5. W81XWH-16-1-0464 (Carl Hauser) Jan 1, 2016 - Dec 31, 2020
    Department of Defense
    DAMP-Mediated Innate Immune Failure and Pneumonia after Trauma
    Role Description: The goal of this Program Project Grant is to provide greater immunobiological understanding of the cellular and molecular mechanisms predisposing to infection
    Role: Co-Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wiredu K, Aduse-Poku E, Shaefi S, Gerber SA. Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies. Anesth Analg. 2022 Dec 29. PMID: 36580411.
    Citations:    Fields:    
  2. Wiredu K, O'Connor S, Naseem H, Brauer BL, Kettenbach AN, Frost HR, Shaefi S, Gerber SA. Intraoperative plasma proteomic changes in cardiac surgery: In search of biomarkers of post-operative delirium. Proteomics Clin Appl. 2022 Dec 25; e2200066. PMID: 36567636.
    Citations:    Fields:    
  3. Qu JZ, Mueller A, McKay TB, Westover MB, Shelton KT, Shaefi S, D'Alessandro DA, Berra L, Brown EN, Houle TT, Akeju O. Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): A single-centre, parallel-arm, randomised, placebo-controlled superiority trial. EClinicalMedicine. 2023 Feb; 56:101796. PMID: 36590787; PMCID: PMC9800196.
    Citations: 1     
  4. Kumaresan A, Pannu A, Mueller A, De Lima A, Naseem H, O'Connor SP, Valencia J, Garcia D, Gosling AF, Talmor D, Shaefi S. Echocardiographic Evidence of Cardiac Atrophy in the Critically Ill. Crit Care Explor. 2022 Nov; 4(11):e0804. PMID: 36419634; PMCID: PMC9678529.
    Citations:    
  5. Bartels K, Howard-Quijano K, Prin M, Shaefi S, Steppan J, Sun EC, Williams B, Fox AA, Namuyonga J, Shaw AD, Vavilala MS, Sessler DI. Meeting Report: First Cardiovascular Outcomes Research in Perioperative Medicine Conference. Anesth Analg. 2023 Feb 01; 136(2):418-420. PMID: 36638519; PMCID: PMC9846581.
    Citations:    Fields:    
  6. Shaefi S, Pannu A, Mueller AL, Flynn B, Evans A, Jabaley CS, Mladinov D, Wall M, Siddiqui S, Douin DJ, Boone MD, Monteith E, Abalama V, Nunnally ME, Cobas M, Warner MA, Stevens RD. Nationwide Clinical Practice Patterns of Anesthesiology Critical Care Physicians: A Survey to Members of the Society of Critical Care Anesthesiologists. Anesth Analg. 2023 Feb 01; 136(2):295-307. PMID: 35950751; PMCID: PMC9840646.
    Citations: 2     Fields:    
  7. O'Gara BP, Beydoun NY, Mueller A, Kumaresan A, Shaefi S. Anesthetic Preferences for Cardiac Anesthesia: A Survey of the Society of Cardiovascular Anesthesiologists. Anesth Analg. 2023 Jan 01; 136(1):51-59. PMID: 35819157; PMCID: PMC9771889.
    Citations:    Fields:    
  8. Valsecchi C, Winterton D, Safaee Fakhr B, Collier AY, Nozari A, Ortoleva J, Mukerji S, Gibson LE, Carroll RW, Shaefi S, Pinciroli R, La Vita C, Ackman JB, Hohmann E, Arora P, Barth WH, Kaimal A, Ichinose F, Berra L. High-Dose Inhaled Nitric Oxide for the Treatment of Spontaneously Breathing Pregnant Patients With Severe Coronavirus Disease 2019 (COVID-19) Pneumonia. Obstet Gynecol. 2022 08 01; 140(2):195-203. PMID: 35852269.
    Citations:    Fields:    Translation:HumansCells
  9. Glaser AC, Kanter JH, Martinez-Camblor P, Taenzer A, Anderson MV, Buhl L, Shaefi S, Pannu A, Boone MD. The Effect of Antiseizure Medication Administration on Mortality and Early Posttraumatic Seizures in Critically Ill Older Adults with Traumatic Brain Injury. Neurocrit Care. 2022 10; 37(2):538-546. PMID: 35641806.
    Citations:    Fields:    
  10. Nunez JI, Gosling AF, O'Gara B, Kennedy KF, Rycus P, Abrams D, Brodie D, Shaefi S, Garan AR, Grandin EW. Correction to: Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis. Intensive Care Med. 2022 May; 48(5):644-645. PMID: 35041017; PMCID: PMC9187497.
    Citations:    Fields:    
  11. O'Gara BP, Shaefi S, Gasangwa DV, Patxot M, Beydoun N, Mueller AL, Sagy I, Novack V, Banner-Goodspeed VM, Kumaresan A, Shapeton A, Spear K, Bose S, Baedorf Kassis EN, Gosling AF, Mahmood FU, Khabbaz K, Subramaniam B, Talmor DS. Anesthetics to Prevent Lung Injury in Cardiac Surgery: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. 2022 10; 36(10):3747-3757. PMID: 35798633.
    Citations:    Fields:    
  12. Grandin EW, Nunez JI, Willar B, Kennedy K, Rycus P, Tonna JE, Kapur NK, Shaefi S, Garan AR. Mechanical Left Ventricular Unloading in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation. J Am Coll Cardiol. 2022 04 05; 79(13):1239-1250. PMID: 35361346; PMCID: PMC9187498.
    Citations: 1     Fields:    Translation:Humans
  13. Barrett CD, Moore HB, Moore EE, Benjamin Christie D, Orfanos S, Anez-Bustillos L, Jhunjhunwala R, Hussain S, Shaefi S, Wang J, Hajizadeh N, Baedorf-Kassis EN, Al-Shammaa A, Capers K, Banner-Goodspeed V, Wright FL, Bull T, Moore PK, Nemec H, Thomas Buchanan J, Nonnemacher C, Rajcooar N, Ramdeo R, Yacoub M, Guevara A, Espinal A, Hattar L, Moraco A, McIntyre R, Talmor DS, Sauaia A, Yaffe MB. MUlticenter STudy of tissue plasminogen activator (alteplase) use in COVID-19 severe respiratory failure (MUST COVID): A retrospective cohort study. Res Pract Thromb Haemost. 2022 Feb; 6(2):e12669. PMID: 35341072; PMCID: PMC8935535.
    Citations: 2     
  14. Calhoun A, Pannu A, Mueller AL, Elmadhoun O, Valencia JD, Krajewski ML, O'Gara BP, Katsiampoura A, O'Connor ST, Chu L, Monteith E, Shankar P, Spear K, Shaefi S. Intraoperative Oxygen Practices in Cardiac Surgery: A National Survey. J Cardiothorac Vasc Anesth. 2022 08; 36(8 Pt B):2917-2926. PMID: 35227576; PMCID: PMC9197961.
    Citations:    Fields:    Translation:Humans
  15. Nunez JI, Gosling AF, O'Gara B, Kennedy KF, Rycus P, Abrams D, Brodie D, Shaefi S, Garan AR, Grandin EW. Bleeding and thrombotic events in adults supported with venovenous extracorporeal membrane oxygenation: an ELSO registry analysis. Intensive Care Med. 2022 Feb; 48(2):213-224. PMID: 34921625; PMCID: PMC9178906.
    Citations: 5     Fields:    Translation:Humans
  16. Douin DJ, Shaefi S, Brenner SK, Gupta S, Park I, Wright FL, Mathews KS, Chan L, Al-Samkari H, Orfanos S, Radbel J, Leaf DE. Tissue Plasminogen Activator in Critically Ill Adults with COVID-19. Ann Am Thorac Soc. 2021 11; 18(11):1917-1921. PMID: 33872546; PMCID: PMC8641829.
    Citations: 2     Fields:    Translation:Humans
  17. Wang N, Vuerich M, Kalbasi A, Graham JJ, Csizmadia E, Manickas-Hill ZJ, Woolley A, David C, Miller EM, Gorman K, Hecht JL, Shaefi S, Robson SC, Longhi MS. Limited TCR repertoire and ENTPD1 dysregulation mark late-stage COVID-19. iScience. 2021 Oct 22; 24(10):103205. PMID: 34608452.
    Citations: 2     
  18. Barrett CD, Moore HB, Moore EE, Wang J, Hajizadeh N, Biffl WL, Lottenberg L, Patel PR, Truitt MS, McIntyre RC, Bull TM, Ammons LA, Ghasabyan A, Chandler J, Douglas IS, Schmidt EP, Moore PK, Wright FL, Ramdeo R, Borrego R, Rueda M, Dhupa A, McCaul DS, Dandan T, Sarkar PK, Khan B, Sreevidya C, McDaniel C, Grossman Verner HM, Pearcy C, Anez-Bustillos L, Baedorf-Kassis EN, Jhunjhunwala R, Shaefi S, Capers K, Banner-Goodspeed V, Talmor DS, Sauaia A, Yaffe MB. Study of Alteplase for Respiratory Failure in SARS-CoV-2 COVID-19: A Vanguard Multicenter, Rapidly Adaptive, Pragmatic, Randomized Controlled Trial. Chest. 2022 03; 161(3):710-727. PMID: 34592318; PMCID: PMC8474873.
    Citations: 9     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  19. Churpek MM, Gupta S, Spicer AB, Hayek SS, Srivastava A, Chan L, Melamed ML, Brenner SK, Radbel J, Madhani-Lovely F, Bhatraju PK, Bansal A, Green A, Goyal N, Shaefi S, Parikh CR, Semler MW, Leaf DE. Machine Learning Prediction of Death in Critically Ill Patients With Coronavirus Disease 2019. Crit Care Explor. 2021 08; 3(8):e0515. PMID: 34476402; PMCID: PMC8378790.
    Citations: 2     
  20. Rhee J, Kuznetsov A, McKay T, Lyons M, Houstis N, Mekkonen J, Ethridge B, Ibala R, Hahm E, Gitlin J, Guseh JS, Kitchen R, Rosenzweig A, Shaefi S, Flaczyk A, Qu J, Akeju O. Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium. Front Aging Neurosci. 2021; 13:699763. PMID: 34456709; PMCID: PMC8386117.
    Citations:    
  21. Mathews KS, Soh H, Shaefi S, Wang W, Bose S, Coca S, Gupta S, Hayek SS, Srivastava A, Brenner SK, Radbel J, Green A, Sutherland A, Leonberg-Yoo A, Shehata A, Schenck EJ, Short SAP, Hernán MA, Chan L, Leaf DE. Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure. Crit Care Med. 2021 07 01; 49(7):1026-1037. PMID: 33595960; PMCID: PMC8277560.
    Citations: 15     Fields:    Translation:HumansCells
  22. Short SAP, Gupta S, Brenner SK, Hayek SS, Srivastava A, Shaefi S, Singh H, Wu B, Bagchi A, Al-Samkari H, Dy R, Wilkinson K, Zakai NA, Leaf DE. d-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019. Crit Care Med. 2021 05 01; 49(5):e500-e511. PMID: 33591017; PMCID: PMC8275993.
    Citations: 13     Fields:    Translation:HumansCells
  23. Murugappan KR, Mueller A, Walsh DP, Shaefi S, Leibowitz A, Sarge T. Rapid Weight Gain Following Weight Cutting in Male and Female Professional Mixed Martial Artists. Int J Sport Nutr Exerc Metab. 2021 05 01; 31(3):259-267. PMID: 33626503.
    Citations:    Fields:    Translation:Humans
  24. Shaefi S, Brenner SK, Gupta S, O'Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE. Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19. Intensive Care Med. 2021 02; 47(2):208-221. PMID: 33528595; PMCID: PMC7851810.
    Citations: 40     Fields:    Translation:Humans
  25. Shaefi S, Shankar P, Mueller AL, O'Gara BP, Spear K, Khabbaz KR, Bagchi A, Chu LM, Banner-Goodspeed V, Leaf DE, Talmor DS, Marcantonio ER, Subramaniam B. Intraoperative Oxygen Concentration and Neurocognition after Cardiac Surgery. Anesthesiology. 2021 02 01; 134(2):189-201. PMID: 33331902; PMCID: PMC7855826.
    Citations: 3     Fields:    Translation:Humans
  26. Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, Hayek SS, Berlin H, Kapoor R, Shaefi S, Melamed ML, Sutherland A, Radbel J, Green A, Garibaldi BT, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Goyal N, Chan L, Mathews KS, Hedayati SS, Dy R, Toth-Manikowski SM, Zhang J, Mallappallil M, Redfern RE, Bansal AD, Short SAP, Vangel MG, Admon AJ, Semler MW, Bauer KA, Hernán MA, Leaf DE. Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19. Ann Intern Med. 2021 05; 174(5):622-632. PMID: 33493012; PMCID: PMC7863679.
    Citations: 33     Fields:    Translation:HumansCells
  27. Esmaeeli S, Valencia J, Buhl LK, Bastos AB, Goudarzi S, Eikermann M, Fehnel C, Pollard R, Thomas A, Ogilvy CS, Shaefi S, Nozari A. Anesthetic management of unruptured intracranial aneurysms: a qualitative systematic review. Neurosurg Rev. 2021 Oct; 44(5):2477-2492. PMID: 33415519; PMCID: PMC9157460.
    Citations:    Fields:    Translation:Humans
  28. Teja B, Alibhai N, Rubenfeld GD, Taggart LR, Jivraj N, Hirji SA, O'Gara BP, Shaefi S. Prevalence of Clostridioides difficile Infection in Critically Ill Patients with Extreme Leukocytosis and Diarrhea. Infect Dis Rep. 2021 Jan 01; 13(1):18-22. PMID: 33401377.
    Citations: 1     
  29. Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2021 01 01; 181(1):41-51. PMID: 33080002; PMCID: PMC7577201.
    Citations: 156     Fields:    Translation:HumansCells
  30. Murugappan KR, Walsh DP, Mittel A, Sontag D, Shaefi S. Veno-venous extracorporeal membrane oxygenation allocation in the COVID-19 pandemic. J Crit Care. 2021 02; 61:221-226. PMID: 33220575.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  31. Gupta S, Hayek SS, Wang W, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Sutherland A, Green A, Shehata AM, Goyal N, Vijayan A, Velez JCQ, Shaefi S, Parikh CR, Arunthamakun J, Athavale AM, Friedman AN, Short SAP, Kibbelaar ZA, Abu Omar S, Admon AJ, Donnelly JP, Gershengorn HB, Hernán MA, Semler MW, Leaf DE. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Intern Med. 2020 11 01; 180(11):1436-1447. PMID: 32667668; PMCID: PMC7364338.
    Citations: 353     Fields:    Translation:HumansPHPublic Health
  32. Hayek SS, Brenner SK, Azam TU, Shadid HR, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O'Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan DM, Bansal A, Mallappallil M, Melamed ML, Shehata AM, Sunderram J, Mathews KS, Sutherland AK, Nallamothu BK, Leaf DE. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. BMJ. 2020 09 30; 371:m3513. PMID: 32998872; PMCID: PMC7525342.
    Citations: 43     Fields:    Translation:HumansCellsPHPublic Health
  33. Molnar MZ, Bhalla A, Azhar A, Tsujita M, Talwar M, Balaraman V, Sodhi A, Kadaria D, Eason JD, Hayek SS, Coca SG, Shaefi S, Neyra JA, Gupta S, Leaf DE, Kovesdy CP. Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States. Am J Transplant. 2020 11; 20(11):3061-3071. PMID: 32844546; PMCID: PMC7460925.
    Citations: 35     Fields:    Translation:HumansCellsPHPublic Health
  34. Santer P, Anstey MH, Patrocínio MD, Wibrow B, Teja B, Shay D, Shaefi S, Parsons CS, Houle TT, Eikermann M. Effect of midodrine versus placebo on time to vasopressor discontinuation in patients with persistent hypotension in the intensive care unit (MIDAS): an international randomised clinical trial. Intensive Care Med. 2020 10; 46(10):1884-1893. PMID: 32885276; PMCID: PMC8273663.
    Citations: 10     Fields:    Translation:Humans
  35. Barrett CD, Oren-Grinberg A, Chao E, Moraco AH, Martin MJ, Reddy SH, Ilg AM, Jhunjhunwala R, Uribe M, Moore HB, Moore EE, Baedorf-Kassis EN, Krajewski ML, Talmor DS, Shaefi S, Yaffe MB. Rescue therapy for severe COVID-19-associated acute respiratory distress syndrome with tissue plasminogen activator: A case series. J Trauma Acute Care Surg. 2020 09; 89(3):453-457. PMID: 32427773; PMCID: PMC7484332.
    Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
  36. Kalsi HS, Thakrar R, Gosling AF, Shaefi S, Navani N. Interventional Pulmonology: A Brave New World. Thorac Surg Clin. 2020 Aug; 30(3):321-338. PMID: 32593365.
    Citations: 3     Fields:    Translation:Humans
  37. Gosling AF, Bose S, Gomez E, Parikh M, Cook C, Sarge T, Shaefi S, Leibowitz A. Perioperative Considerations for Tracheostomies in the Era of COVID-19. Anesth Analg. 2020 08; 131(2):378-386. PMID: 32459668; PMCID: PMC7273938.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  38. Boone MD, Sites B, von Recklinghausen FM, Mueller A, Taenzer AH, Shaefi S. Economic Burden of Postoperative Neurocognitive Disorders Among US Medicare Patients. JAMA Netw Open. 2020 07 01; 3(7):e208931. PMID: 32735336; PMCID: PMC7395237.
    Citations: 9     Fields:    Translation:Humans
  39. De Biasio JC, Mittel AM, Mueller AL, Ferrante LE, Kim DH, Shaefi S. Frailty in Critical Care Medicine: A Review. Anesth Analg. 2020 06; 130(6):1462-1473. PMID: 32384336; PMCID: PMC7426653.
    Citations: 17     Fields:    Translation:Humans
  40. Cahill LA, Guo F, Nguyen J, Zhang F, Seshadri A, Keegan J, Hauser CJ, Otterbein LE, Robson S, Shaefi S, Yaffe MB, Lederer JA. Circulating Factors in Trauma Plasma Activate Specific Human Immune Cell Subsets. Injury. 2020 Apr; 51(4):819-829. PMID: 32171537.
    Citations: 2     Fields:    Translation:HumansCells
  41. O'Gara BP, Mueller A, Gasangwa DVI, Patxot M, Shaefi S, Khabbaz K, Banner-Goodspeed V, Pascal-Leone A, Marcantonio ER, Subramaniam B. Prevention of Early Postoperative Decline: A Randomized, Controlled Feasibility Trial of Perioperative Cognitive Training. Anesth Analg. 2020 03; 130(3):586-595. PMID: 31569161; PMCID: PMC7154961.
    Citations: 13     Fields:    Translation:Humans
  42. Evans AS, Weiner MM, Shaefi S, Patel PA, Townsley MM, Kumaresan A, Feinman JW, Fritz AV, Martin AK, Steinberg TB, Renew JR, Gui JL, Radvansky B, Bhatt H, Subramani S, Sharma A, Gutsche JT, Augoustides JG, Ramakrishna H. The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2019. J Cardiothorac Vasc Anesth. 2020 Jan; 34(1):1-11. PMID: 31759862.
    Citations:    Fields:    Translation:Humans
  43. Lee GR, Shaefi S, Otterbein LE. HO-1 and CD39: It Takes Two to Protect the Realm. Front Immunol. 2019; 10:1765. PMID: 31402920; PMCID: PMC6676250.
    Citations: 6     Fields:    Translation:HumansAnimals
  44. Lukannek C, Shaefi S, Platzbecker K, Raub D, Santer P, Nabel S, Lecamwasam HS, Houle TT, Eikermann M. The development and validation of the Score for the Prediction of Postoperative Respiratory Complications (SPORC-2) to predict the requirement for early postoperative tracheal re-intubation: a hospital registry study. Anaesthesia. 2019 09; 74(9):1165-1174. PMID: 31222727; PMCID: PMC7424553.
    Citations: 5     Fields:    Translation:Humans
  45. Kelly B, Patlak J, Shaefi S, Boone D, Mueller A, Talmor D. Evaluation of qSOFA as a Predictor of Mortality Among ICU Patients With Positive Clinical Cultures-A Retrospective Cohort Study. J Intensive Care Med. 2020 Nov; 35(11):1278-1284. PMID: 31208272.
    Citations: 1     Fields:    Translation:Humans
  46. O'Gara B, Subramaniam B, Shaefi S, Mueller A, Banner-Goodspeed V, Talmor D. Anesthetics to Prevent Lung Injury in Cardiac Surgery (APLICS): a protocol for a randomized controlled trial. Trials. 2019 May 31; 20(1):312. PMID: 31151474; PMCID: PMC6544964.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  47. Subramaniam B, Shankar P, Shaefi S, Mueller A, O'Gara B, Banner-Goodspeed V, Gallagher J, Gasangwa D, Patxot M, Packiasabapathy S, Mathur P, Eikermann M, Talmor D, Marcantonio ER. Effect of Intravenous Acetaminophen vs Placebo Combined With Propofol or Dexmedetomidine on Postoperative Delirium Among Older Patients Following Cardiac Surgery: The DEXACET Randomized Clinical Trial. JAMA. 2019 02 19; 321(7):686-696. PMID: 30778597; PMCID: PMC6439609.
    Citations: 53     Fields:    Translation:Humans
  48. Packiasabapathy S, Susheela AT, Mueller A, Patxot M, Gasangwa DV, O'Gara B, Shaefi S, Marcantonio ER, Yeh GY, Subramaniam B. Guided meditation as an adjunct to enhance postoperative recovery after cardiac surgery: study protocol for a prospective randomized controlled feasibility trial. Trials. 2019 Jan 11; 20(1):39. PMID: 30635064; PMCID: PMC6329114.
    Citations: 3     Fields:    Translation:HumansCTClinical Trials
  49. Rostin P, Teja BJ, Friedrich S, Shaefi S, Murugappan KR, Ramachandran SK, Houle TT, Eikermann M. The association of early postoperative desaturation in the operating theatre with hospital discharge to a skilled nursing or long-term care facility. Anaesthesia. 2019 Apr; 74(4):457-467. PMID: 30632138.
    Citations: 8     Fields:    Translation:Humans
  50. Murugappan KR, Cocchi MN, Bose S, Neves SE, Cook CH, Sarge T, Shaefi S, Leibowitz A. Case Study: Fatal Exertional Rhabdomyolysis Possibly Related to Drastic Weight Cutting. Int J Sport Nutr Exerc Metab. 2019 Jan 01; 29(1):68-71. PMID: 29893586.
    Citations: 4     Fields:    
  51. O'Gara B, Marcantonio ER, Pascual-Leone A, Shaefi S, Mueller A, Banner-Goodspeed V, Talmor D, Subramaniam B. Prevention of Early Postoperative Decline (PEaPoD): protocol for a randomized, controlled feasibility trial. Trials. 2018 Dec 11; 19(1):676. PMID: 30537982; PMCID: PMC6290549.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  52. Evans AS, Weiner M, Jain A, Patel PA, Jayaraman AL, Townsley MM, Shah R, Gutsche JT, Renew JR, Ha B, Martin AK, Linganna R, Leong R, Bhatt HV, Garcia H, Feduska E, Shaefi S, Feinman JW, Eden C, Weiss SJ, Silvay G, Augoustides JG, Ramakrishna H. The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights from 2018. J Cardiothorac Vasc Anesth. 2019 Jan; 33(1):2-11. PMID: 30472017.
    Citations: 1     Fields:    Translation:Humans
  53. Loberman D, Shaefi S, Mohr R, Dombrowski P, Zelman RB, Zheng Y, Pirundini PA, Ziv-Baran T. Trans-catheter aortic valve replacement program in a community hospital - Comparison with US national data. PLoS One. 2018; 13(9):e0204766. PMID: 30261048.
    Citations: 1     Fields:    Translation:Humans
  54. Cormican D, Jayaraman AL, Sheu R, Peterson C, Narasimhan S, Shaefi S, Núñez-Gil IJ, Ramakrishna H. Coronary Artery Bypass Grafting Versus Percutaneous Transcatheter Coronary Interventions: Analysis of Outcomes in Myocardial Revascularization. J Cardiothorac Vasc Anesth. 2019 Sep; 33(9):2569-2588. PMID: 30340948.
    Citations: 1     Fields:    Translation:Humans
  55. Shankar P, Mueller A, Packiasabapathy S, Gasangwa D, Patxot M, O'Gara B, Shaefi S, Marcantonio ER, Subramaniam B. Dexmedetomidine and intravenous acetaminophen for the prevention of postoperative delirium following cardiac surgery (DEXACET trial): protocol for a prospective randomized controlled trial. Trials. 2018 Jun 22; 19(1):326. PMID: 29929533; PMCID: PMC6013954.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  56. Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O. Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial. BMJ Open. 2018 04 20; 8(4):e020316. PMID: 29678977.
    Citations: 14     Fields:    Translation:Humans
  57. Shaefi S, Mittel A, Loberman D, Ramakrishna H. Off-Pump Versus On-Pump Coronary Artery Bypass Grafting-A Systematic Review and Analysis of Clinical Outcomes. J Cardiothorac Vasc Anesth. 2019 Jan; 33(1):232-244. PMID: 29753665.
    Citations: 12     Fields:    Translation:Humans
  58. Patlak J, Shaefi S, Buhl L, Boone MD. Neurocritical Care Needs Predictive Scores That Succeed at Predicting Failure as Well as They Predict Success. Anesthesiology. 2018 03; 128(3):686-687. PMID: 29438255.
    Citations:    Fields:    Translation:Humans
  59. Shaefi S, Eikermann M. Analysing tidal volumes early after a positive end-expiratory pressure increase: a new way to determine optimal PEEP in the operating theatre? Br J Anaesth. 2018 04; 120(4):623-626. PMID: 29576103.
    Citations: 2     Fields:    
  60. Shankar P, Robson SC, Otterbein LE, Shaefi S. Clinical Implications of Hyperoxia. Int Anesthesiol Clin. 2018; 56(1):68-79. PMID: 29227312.
    Citations: 2     Fields:    Translation:Humans
  61. Shaefi S, Marcantonio ER, Mueller A, Banner-Goodspeed V, Robson SC, Spear K, Otterbein LE, O'Gara BP, Talmor DS, Subramaniam B. Intraoperative oxygen concentration and neurocognition after cardiac surgery: study protocol for a randomized controlled trial. Trials. 2017 Dec 19; 18(1):600. PMID: 29254495.
    Citations: 5     Fields:    Translation:Humans
  62. Shaefi S, Mittel A, Klick J, Evans A, Ivascu NS, Gutsche J, Augoustides JGT. Vasoplegia After Cardiovascular Procedures-Pathophysiology and Targeted Therapy. J Cardiothorac Vasc Anesth. 2018 04; 32(2):1013-1022. PMID: 29223724.
    Citations: 19     Fields:    Translation:Humans
  63. Bagchi A, Rudolph MI, Ng PY, Timm FP, Long DR, Shaefi S, Ladha K, Vidal Melo MF, Eikermann M. The association of postoperative pulmonary complications in 109,360 patients with pressure-controlled or volume-controlled ventilation. Anaesthesia. 2017 Nov; 72(11):1334-1343. PMID: 28891046; PMCID: PMC6696935.
    Citations: 14     Fields:    Translation:Humans
  64. Amir R, Knio ZO, Mahmood F, Oren-Grinberg A, Leibowitz A, Bose R, Shaefi S, Mitchell JD, Ahmed M, Bardia A, Talmor D, Matyal R. Ultrasound as a Screening Tool for Central Venous Catheter Positioning and Exclusion of Pneumothorax. Crit Care Med. 2017 Jul; 45(7):1192-1198. PMID: 28422778.
    Citations: 7     Fields:    Translation:Humans
  65. Boone MD, Jinadasa SP, Mueller A, Shaefi S, Kasper EM, Hanafy KA, O'Gara BP, Talmor DS. The Effect of Positive End-Expiratory Pressure on Intracranial Pressure and Cerebral Hemodynamics. Neurocrit Care. 2017 04; 26(2):174-181. PMID: 27848125.
    Citations: 19     Fields:    Translation:Humans
  66. Patlak J, Bose S, Shankar P, Shaefi S. 1622: MECHANICAL MITRAL VALVE THROMBOSIS PRESENTING AS SEPTIC SHOCK. Crit Care Med. 2016 Dec; 44(12 Suppl 1):481. PMID: 27851257.
    Citations:    
  67. Shaefi S, Mueller A, Banner-Goodspeed V, Shahul S, Sarge T, Sevransky J, Talmor D. 937: PREVALENCE AND OUTCOMES OF HYPEROXIA IN THE INTENSIVE CARE UNIT. Crit Care Med. 2016 Dec; 44(12 Suppl 1):310. PMID: 27850575.
    Citations:    
  68. Katsios C, Doumouras A, Shaefi S, Novack V, Talmor D. 22: CONSERVATIVE FLUID STRATEGIES DECREASE MORTALITY IN SEPSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Crit Care Med. 2016 Dec; 44(12 Suppl 1):92. PMID: 27849702.
    Citations:    
  69. Amir R, Knio Z, Mahmood F, Oren-Grinberg A, Leibowitz A, Shaefi S, Mitchell J, Matyal R. 1103: ULTRASOUND AS A SCREENING TOOL FOR CENTRAL VENOUS CATHETER POSITIONING AND EXCLUSION OF PNEUMOTHORAX. Crit Care Med. 2016 Dec; 44(12 Suppl 1):351. PMID: 27850740.
    Citations:    
  70. Shaefi S, Mittel AM, Hyam JA, Boone MD, Chen CC, Kasper EM. Hypothermia for severe traumatic brain injury in adults: Recent lessons from randomized controlled trials. Surg Neurol Int. 2016; 7:103. PMID: 28168089; PMCID: PMC5223395.
    Citations: 4     
  71. Nizamuddin J, Mahmood F, Tung A, Mueller A, Brown SM, Shaefi S, O'Connor M, Talmor D, Shahul S. Interval Changes in Myocardial Performance Index Predict Outcome in Severe Sepsis. J Cardiothorac Vasc Anesth. 2017 Jun; 31(3):957-964. PMID: 28094172.
    Citations: 6     Fields:    Translation:Humans
  72. Ramakrishna H, Gutsche JT, Patel PA, Evans AS, Weiner M, Morozowich ST, Gordon EK, Riha H, Bracker J, Ghadimi K, Murphy S, Spitz W, MacKay E, Cios TJ, Malhotra AK, Baron E, Shaefi S, Fassl J, Weiss SJ, Silvay G, Augoustides JG. The Year in Cardiothoracic and Vascular Anesthesia: Selected Highlights From 2016. J Cardiothorac Vasc Anesth. 2017 02; 31(1):1-13. PMID: 28041810.
    Citations: 1     Fields:    
  73. Shaefi S, Talmor DS, Subramaniam B. Oxygen Therapy: When Is Too Much Too Much? Anesthesiology. 2016 09; 125(3):449-50. PMID: 27404220.
    Citations: 1     Fields:    Translation:Humans
  74. Shahul S, Tung A, Minhaj M, Nizamuddin J, Wenger J, Mahmood E, Mueller A, Shaefi S, Scavone B, Kociol RD, Talmor D, Rana S. Racial Disparities in Comorbidities, Complications, and Maternal and Fetal Outcomes in Women With Preeclampsia/eclampsia. Hypertens Pregnancy. 2015 Nov; 34(4):506-515. PMID: 26636247.
    Citations: 36     Fields:    
  75. Shaefi S, O'Gara B, Kociol RD, Joynt K, Mueller A, Nizamuddin J, Mahmood E, Talmor D, Shahul S. Effect of cardiogenic shock hospital volume on mortality in patients with cardiogenic shock. J Am Heart Assoc. 2015 Jan 05; 4(1):e001462. PMID: 25559014.
    Citations: 25     Fields:    Translation:Humans
  76. Shahul S, Hacker MR, Novack V, Mueller A, Shaefi S, Mahmood B, Ali SH, Talmor D. The effect of hospital volume on mortality in patients admitted with severe sepsis. PLoS One. 2014; 9(9):e108754. PMID: 25264788.
    Citations: 4     Fields:    Translation:Humans
  77. José RJ, Shaefi S, Navani N. Anesthesia for bronchoscopy. Curr Opin Anaesthesiol. 2014 Aug; 27(4):453-7. PMID: 24785119.
    Citations: 13     Fields:    Translation:Humans
  78. Beitler JR, Shaefi S, Montesi SB, Devlin A, Loring SH, Talmor D, Malhotra A. Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis. Intensive Care Med. 2014 Mar; 40(3):332-41. PMID: 24435203.
    Citations: 63     Fields:    Translation:Humans
  79. Odom SR, Shaefi S, Gupta A, Reed AJ. The seventh patient. Am J Respir Crit Care Med. 2013 Jul 15; 188(2):131-2. PMID: 23855690.
    Citations:    Fields:    Translation:Humans
  80. José RJ, Shaefi S, Navani N. Sedation for flexible bronchoscopy: current and emerging evidence. Eur Respir Rev. 2013 Jun 01; 22(128):106-16. PMID: 23728864; PMCID: PMC9487384.
    Citations: 28     Fields:    Translation:Humans
  81. Malhotra G, Elkassabany NM, Frogel J, Patel AR, Steinberg G, Shaefi S, Mahmood F. CASE 8--2012 intraoperative embolization of renal cell tumor thrombus during radical nephrectomy. J Cardiothorac Vasc Anesth. 2012 Dec; 26(6):1124-30. PMID: 22883446.
    Citations:    Fields:    Translation:Humans
  82. Coleman MD, Shaefi S, Sladen RN. Preventing acute kidney injury after cardiac surgery. Curr Opin Anaesthesiol. 2011 Feb; 24(1):70-6. PMID: 21157303.
    Citations: 30     Fields:    Translation:Humans
  83. Khawaja OM, Reed JT, Shaefi S, Chitilian HV, Sandberg WS. Crisis resource management of the airway in a patient with Klippel-Feil syndrome, congenital deafness, and aortic dissection. Anesth Analg. 2009 Apr; 108(4):1220-5. PMID: 19299791.
    Citations: 2     Fields:    Translation:Humans
  84. Bateman BT, Schumacher HC, Wang S, Shaefi S, Berman MF. Perioperative acute ischemic stroke in noncardiac and nonvascular surgery: incidence, risk factors, and outcomes. Anesthesiology. 2009 Feb; 110(2):231-8. PMID: 19194149.
    Citations: 69     Fields:    Translation:Humans
  85. Newman S, Stygall J, Hirani S, Shaefi S, Maze M. Postoperative cognitive dysfunction after noncardiac surgery: a systematic review. Anesthesiology. 2007 Mar; 106(3):572-90. PMID: 17325517.
    Citations: 161     Fields:    Translation:Humans
  86. Hirani SP, Hyam JA, Shaefi S, Walker JM, Walesby RK, Newman SP. An examination of factors influencing the choice of therapy for patients with coronary artery disease. BMC Cardiovasc Disord. 2006 Jul 04; 6:31. PMID: 16820053.
    Citations:    Fields:    Translation:Humans
  87. Bennett-Guerrero E, Hyam JA, Shaefi S, Prytherch DR, Sutton GL, Weaver PC, Mythen MG, Grocott MP, Parides MK. Comparison of P-POSSUM risk-adjusted mortality rates after surgery between patients in the USA and the UK. Br J Surg. 2003 Dec; 90(12):1593-8. PMID: 14648741.
    Citations: 30     Fields:    Translation:Humans
  88. Shaefi S, Harkness W. Current status of surgery in the management of epilepsy. Epilepsia. 2003; 44 Suppl 1:43-7. PMID: 12558832.
    Citations: 1     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.