Christopher Joseph O'Donnell, M.D.
Co-Author
This page shows the publications co-authored by Christopher O'Donnell and Sekar Kathiresan.
Connection Strength
5.895
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Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata. Am J Cardiol. 2007 Feb 01; 99(3):310-4.
Score: 0.345
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Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1405-12.
Score: 0.329
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Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels. Circulation. 2005 Sep 20; 112(12):1728-35.
Score: 0.317
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Mendelian Randomization Study of ACLY and Cardiovascular Disease. N Engl J Med. 2020 08 13; 383(7):e50.
Score: 0.222
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Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium. Am J Cardiol. 2018 05 15; 121(10):1246-1252.
Score: 0.187
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Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study. J Am Heart Assoc. 2016 Feb 22; 5(2).
Score: 0.163
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Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 Feb 05; 518(7537):102-6.
Score: 0.150
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Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov 27; 371(22):2072-82.
Score: 0.149
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Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014 Jul 03; 371(1):22-31.
Score: 0.145
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Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17; 128(12):1310-24.
Score: 0.137
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Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study. J Am Coll Cardiol. 2012 Dec 11; 60(23):2364-71.
Score: 0.130
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Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012 Aug 11; 380(9841):572-80.
Score: 0.126
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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012; 8(3):e1002607.
Score: 0.124
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Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation. 2011 Dec 20; 124(25):2855-64.
Score: 0.122
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Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 05; 466(7307):707-13.
Score: 0.111
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Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium. J Am Coll Cardiol. 2010 Jun 01; 55(22):2491-8.
Score: 0.110
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Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1849-54.
Score: 0.109
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Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation. 2010 Mar 30; 121(12):1382-92.
Score: 0.108
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Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan; 41(1):56-65.
Score: 0.099
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Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. BMC Med Genet. 2007 Sep 19; 8 Suppl 1:S12.
Score: 0.091
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Heritability, linkage, and genetic associations of exercise treadmill test responses. Circulation. 2007 Jun 12; 115(23):2917-24.
Score: 0.089
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Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006 Mar 21; 113(11):1415-23.
Score: 0.082
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Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community. Circulation. 2005 Sep 06; 112(10):1419-27.
Score: 0.079
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On the significance of linkage studies of complex traits. Am J Hum Genet. 2004 Jul; 75(1):151-2; author reply 152-4.
Score: 0.073
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Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest. 2013 Oct; 123(10):4208-18.
Score: 0.069
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Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 01; 20(11):2273-84.
Score: 0.058
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Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020 10; 586(7831):769-775.
Score: 0.056
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Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation. 2020 10 27; 142(17):1633-1646.
Score: 0.056
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Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. Nat Genet. 2019 11; 51(11):1574-1579.
Score: 0.053
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Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Circulation. 2019 09 17; 140(12):1031-1040.
Score: 0.052
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Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med. 2019 08; 25(8):1274-1279.
Score: 0.051
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Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018 12; 50(12):1755.
Score: 0.049
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Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. Nat Genet. 2018 11; 50(11):1514-1523.
Score: 0.049
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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018 10; 50(10):1412-1425.
Score: 0.049
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Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions. Circulation. 2017 Jun 13; 135(24):2336-2353.
Score: 0.044
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Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 04 06; 20(4):547-557.e7.
Score: 0.044
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Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec; 9(6):511-520.
Score: 0.043
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Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016 10; 48(10):1162-70.
Score: 0.042
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The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016 10; 48(10):1171-1184.
Score: 0.042
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An exome array study of the plasma metabolome. Nat Commun. 2016 07 25; 7:12360.
Score: 0.042
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Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016 Jul 07; 99(1):8-21.
Score: 0.042
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Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. J Am Coll Cardiol. 2016 Feb 02; 67(4):407-416.
Score: 0.041
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A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015 Oct; 47(10):1121-1130.
Score: 0.039
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Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet. 2015 Jun; 1(1):e10.
Score: 0.039
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Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1712-22.
Score: 0.039
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Genetically determined height and coronary artery disease. N Engl J Med. 2015 Apr 23; 372(17):1608-18.
Score: 0.038
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Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis. JAMA. 2014 Nov 05; 312(17):1764-71.
Score: 0.037
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Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet. 2014 Jul; 10(7):e1004502.
Score: 0.036
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Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1093-101.
Score: 0.036
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Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014 Feb 06; 94(2):223-32.
Score: 0.035
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Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014 Feb 06; 94(2):233-45.
Score: 0.035
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Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke. 2014 Feb; 45(2):403-12.
Score: 0.035
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Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. 2014 Jan; 45(1):24-36.
Score: 0.035
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Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat Genet. 2013 Nov; 45(11):1380-5.
Score: 0.035
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Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One. 2013; 8(7):e68095.
Score: 0.034
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Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013 Sep; 98(3):668-76.
Score: 0.034
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Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 2013 Feb 07; 368(6):503-12.
Score: 0.033
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Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Circ Cardiovasc Genet. 2013 Feb; 6(1):82-8.
Score: 0.033
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Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013 Jan; 45(1):25-33.
Score: 0.033
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Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood. 2012 Dec 06; 120(24):4873-81.
Score: 0.032
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Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am J Hum Genet. 2012 Sep 07; 91(3):513-9.
Score: 0.032
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Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One. 2012; 7(8):e41730.
Score: 0.032
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Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet. 2011 Sep 11; 43(10):940-7.
Score: 0.030
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11; 478(7367):103-9.
Score: 0.030
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A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):403-12.
Score: 0.029
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An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1916-26.
Score: 0.029
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011 Mar 06; 43(4):333-8.
Score: 0.029
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Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 02; 56(19):1552-63.
Score: 0.028
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Nov; 42(11):937-48.
Score: 0.028
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Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet. 2010 Oct; 3(5):475-83.
Score: 0.028
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Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Oct 14; 467(7317):832-8.
Score: 0.028
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Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec; 59(12):3229-39.
Score: 0.028
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Inflammation, kidney function and albuminuria in the Framingham Offspring cohort. Nephrol Dial Transplant. 2011 Mar; 26(3):920-6.
Score: 0.028
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Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet. 2010 Aug; 42(8):684-7.
Score: 0.028
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Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study. Obesity (Silver Spring). 2010 May; 18(5):1039-45.
Score: 0.026
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A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. 2009 Nov; 41(11):1182-90.
Score: 0.026
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Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA. 2009 Jul 08; 302(2):168-78.
Score: 0.026
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Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009 Jun; 41(6):666-76.
Score: 0.025
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Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet. 2009 Apr; 2(2):125-33.
Score: 0.025
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Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009 Mar; 41(3):334-41.
Score: 0.025
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New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 2009 Mar; 41(3):280-2.
Score: 0.025
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Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008 Feb 01; 167(3):313-20.
Score: 0.023
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Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet. 2007 Sep 19; 8 Suppl 1:S2.
Score: 0.023
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Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007 Sep 11; 116(11):1234-41.
Score: 0.023
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Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study. Hypertension. 2007 Jun; 49(6):1285-90.
Score: 0.022
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Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample. Hypertension. 2007 Apr; 49(4):846-56.
Score: 0.022
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The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet. 2007; 8 Suppl 1:S1.
Score: 0.022
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PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample. Obesity (Silver Spring). 2006 May; 14(5):753-8.
Score: 0.021
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Aging syndrome genes and premature coronary artery disease. BMC Med Genet. 2005 Oct 31; 6:38.
Score: 0.020
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CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation. 2005 Aug 23; 112(8):1113-20.
Score: 0.020
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.