Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Christopher Joseph O'Donnell, M.D.

Co-Author

This page shows the publications co-authored by Christopher O'Donnell and Sekar Kathiresan.
Connection Strength

5.895
  1. Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata. Am J Cardiol. 2007 Feb 01; 99(3):310-4.
    View in: PubMed
    Score: 0.345
  2. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1405-12.
    View in: PubMed
    Score: 0.329
  3. Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels. Circulation. 2005 Sep 20; 112(12):1728-35.
    View in: PubMed
    Score: 0.317
  4. Mendelian Randomization Study of ACLY and Cardiovascular Disease. N Engl J Med. 2020 08 13; 383(7):e50.
    View in: PubMed
    Score: 0.222
  5. Observational and Genetic Associations of Resting Heart Rate With Aortic Valve Calcium. Am J Cardiol. 2018 05 15; 121(10):1246-1252.
    View in: PubMed
    Score: 0.187
  6. Cardiovascular Event Prediction and Risk Reclassification by Coronary, Aortic, and Valvular Calcification in the Framingham Heart Study. J Am Heart Assoc. 2016 Feb 22; 5(2).
    View in: PubMed
    Score: 0.163
  7. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015 Feb 05; 518(7537):102-6.
    View in: PubMed
    Score: 0.150
  8. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med. 2014 Nov 27; 371(22):2072-82.
    View in: PubMed
    Score: 0.149
  9. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014 Jul 03; 371(1):22-31.
    View in: PubMed
    Score: 0.145
  10. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17; 128(12):1310-24.
    View in: PubMed
    Score: 0.137
  11. Relations of long-term and contemporary lipid levels and lipid genetic risk scores with coronary artery calcium in the framingham heart study. J Am Coll Cardiol. 2012 Dec 11; 60(23):2364-71.
    View in: PubMed
    Score: 0.130
  12. Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet. 2012 Aug 11; 380(9841):572-80.
    View in: PubMed
    Score: 0.126
  13. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012; 8(3):e1002607.
    View in: PubMed
    Score: 0.124
  14. Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction. Circulation. 2011 Dec 20; 124(25):2855-64.
    View in: PubMed
    Score: 0.122
  15. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010 Aug 05; 466(7307):707-13.
    View in: PubMed
    Score: 0.111
  16. Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium. J Am Coll Cardiol. 2010 Jun 01; 55(22):2491-8.
    View in: PubMed
    Score: 0.110
  17. Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1849-54.
    View in: PubMed
    Score: 0.109
  18. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation. 2010 Mar 30; 121(12):1382-92.
    View in: PubMed
    Score: 0.108
  19. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan; 41(1):56-65.
    View in: PubMed
    Score: 0.099
  20. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. BMC Med Genet. 2007 Sep 19; 8 Suppl 1:S12.
    View in: PubMed
    Score: 0.091
  21. Heritability, linkage, and genetic associations of exercise treadmill test responses. Circulation. 2007 Jun 12; 115(23):2917-24.
    View in: PubMed
    Score: 0.089
  22. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006 Mar 21; 113(11):1415-23.
    View in: PubMed
    Score: 0.082
  23. Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community. Circulation. 2005 Sep 06; 112(10):1419-27.
    View in: PubMed
    Score: 0.079
  24. On the significance of linkage studies of complex traits. Am J Hum Genet. 2004 Jul; 75(1):151-2; author reply 152-4.
    View in: PubMed
    Score: 0.073
  25. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest. 2013 Oct; 123(10):4208-18.
    View in: PubMed
    Score: 0.069
  26. Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study. Hum Mol Genet. 2011 Jun 01; 20(11):2273-84.
    View in: PubMed
    Score: 0.058
  27. Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells. Nature. 2020 10; 586(7831):769-775.
    View in: PubMed
    Score: 0.056
  28. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation. 2020 10 27; 142(17):1633-1646.
    View in: PubMed
    Score: 0.056
  29. Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease. Nat Genet. 2019 11; 51(11):1574-1579.
    View in: PubMed
    Score: 0.053
  30. Association of APOL1 Risk Alleles With Cardiovascular Disease in Blacks in the Million Veteran Program. Circulation. 2019 09 17; 140(12):1031-1040.
    View in: PubMed
    Score: 0.052
  31. Genome-wide association study of peripheral artery disease in the Million Veteran Program. Nat Med. 2019 08; 25(8):1274-1279.
    View in: PubMed
    Score: 0.051
  32. Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018 12; 50(12):1755.
    View in: PubMed
    Score: 0.049
  33. Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program. Nat Genet. 2018 11; 50(11):1514-1523.
    View in: PubMed
    Score: 0.049
  34. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat Genet. 2018 10; 50(10):1412-1425.
    View in: PubMed
    Score: 0.049
  35. Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions. Circulation. 2017 Jun 13; 135(24):2336-2353.
    View in: PubMed
    Score: 0.044
  36. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 04 06; 20(4):547-557.e7.
    View in: PubMed
    Score: 0.044
  37. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec; 9(6):511-520.
    View in: PubMed
    Score: 0.043
  38. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. Nat Genet. 2016 10; 48(10):1162-70.
    View in: PubMed
    Score: 0.042
  39. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016 10; 48(10):1171-1184.
    View in: PubMed
    Score: 0.042
  40. An exome array study of the plasma metabolome. Nat Commun. 2016 07 25; 7:12360.
    View in: PubMed
    Score: 0.042
  41. Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J Hum Genet. 2016 Jul 07; 99(1):8-21.
    View in: PubMed
    Score: 0.042
  42. Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study. J Am Coll Cardiol. 2016 Feb 02; 67(4):407-416.
    View in: PubMed
    Score: 0.041
  43. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015 Oct; 47(10):1121-1130.
    View in: PubMed
    Score: 0.039
  44. Genetic analysis for a shared biological basis between migraine and coronary artery disease. Neurol Genet. 2015 Jun; 1(1):e10.
    View in: PubMed
    Score: 0.039
  45. Systems Genetics Analysis of Genome-Wide Association Study Reveals Novel Associations Between Key Biological Processes and Coronary Artery Disease. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1712-22.
    View in: PubMed
    Score: 0.039
  46. Genetically determined height and coronary artery disease. N Engl J Med. 2015 Apr 23; 372(17):1608-18.
    View in: PubMed
    Score: 0.038
  47. Association of low-density lipoprotein cholesterol-related genetic variants with aortic valve calcium and incident aortic stenosis. JAMA. 2014 Nov 05; 312(17):1764-71.
    View in: PubMed
    Score: 0.037
  48. Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease. PLoS Genet. 2014 Jul; 10(7):e1004502.
    View in: PubMed
    Score: 0.036
  49. Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1093-101.
    View in: PubMed
    Score: 0.036
  50. Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. Am J Hum Genet. 2014 Feb 06; 94(2):223-32.
    View in: PubMed
    Score: 0.035
  51. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet. 2014 Feb 06; 94(2):233-45.
    View in: PubMed
    Score: 0.035
  52. Predicting stroke through genetic risk functions: the CHARGE Risk Score Project. Stroke. 2014 Feb; 45(2):403-12.
    View in: PubMed
    Score: 0.035
  53. Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants. Stroke. 2014 Jan; 45(1):24-36.
    View in: PubMed
    Score: 0.035
  54. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat Genet. 2013 Nov; 45(11):1380-5.
    View in: PubMed
    Score: 0.035
  55. Best practices and joint calling of the HumanExome BeadChip: the CHARGE Consortium. PLoS One. 2013; 8(7):e68095.
    View in: PubMed
    Score: 0.034
  56. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013 Sep; 98(3):668-76.
    View in: PubMed
    Score: 0.034
  57. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 2013 Feb 07; 368(6):503-12.
    View in: PubMed
    Score: 0.033
  58. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Circ Cardiovasc Genet. 2013 Feb; 6(1):82-8.
    View in: PubMed
    Score: 0.033
  59. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013 Jan; 45(1):25-33.
    View in: PubMed
    Score: 0.033
  60. Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. Blood. 2012 Dec 06; 120(24):4873-81.
    View in: PubMed
    Score: 0.032
  61. Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am J Hum Genet. 2012 Sep 07; 91(3):513-9.
    View in: PubMed
    Score: 0.032
  62. Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction. PLoS One. 2012; 7(8):e41730.
    View in: PubMed
    Score: 0.032
  63. Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque. Nat Genet. 2011 Sep 11; 43(10):940-7.
    View in: PubMed
    Score: 0.030
  64. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 2011 Sep 11; 478(7367):103-9.
    View in: PubMed
    Score: 0.030
  65. A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease. Circ Cardiovasc Genet. 2011 Aug 01; 4(4):403-12.
    View in: PubMed
    Score: 0.029
  66. An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2011 Aug; 31(8):1916-26.
    View in: PubMed
    Score: 0.029
  67. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011 Mar 06; 43(4):333-8.
    View in: PubMed
    Score: 0.029
  68. Lack of association between the Trp719Arg polymorphism in kinesin-like protein-6 and coronary artery disease in 19 case-control studies. J Am Coll Cardiol. 2010 Nov 02; 56(19):1552-63.
    View in: PubMed
    Score: 0.028
  69. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet. 2010 Nov; 42(11):937-48.
    View in: PubMed
    Score: 0.028
  70. Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Circ Cardiovasc Genet. 2010 Oct; 3(5):475-83.
    View in: PubMed
    Score: 0.028
  71. Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature. 2010 Oct 14; 467(7317):832-8.
    View in: PubMed
    Score: 0.028
  72. Common variants at 10 genomic loci influence hemoglobin A1(C) levels via glycemic and nonglycemic pathways. Diabetes. 2010 Dec; 59(12):3229-39.
    View in: PubMed
    Score: 0.028
  73. Inflammation, kidney function and albuminuria in the Framingham Offspring cohort. Nephrol Dial Transplant. 2011 Mar; 26(3):920-6.
    View in: PubMed
    Score: 0.028
  74. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet. 2010 Aug; 42(8):684-7.
    View in: PubMed
    Score: 0.028
  75. Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study. Obesity (Silver Spring). 2010 May; 18(5):1039-45.
    View in: PubMed
    Score: 0.026
  76. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. Nat Genet. 2009 Nov; 41(11):1182-90.
    View in: PubMed
    Score: 0.026
  77. Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data. JAMA. 2009 Jul 08; 302(2):168-78.
    View in: PubMed
    Score: 0.026
  78. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 2009 Jun; 41(6):666-76.
    View in: PubMed
    Score: 0.025
  79. Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet. 2009 Apr; 2(2):125-33.
    View in: PubMed
    Score: 0.025
  80. Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants. Nat Genet. 2009 Mar; 41(3):334-41.
    View in: PubMed
    Score: 0.025
  81. New susceptibility locus for coronary artery disease on chromosome 3q22.3. Nat Genet. 2009 Mar; 41(3):280-2.
    View in: PubMed
    Score: 0.025
  82. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008 Feb 01; 167(3):313-20.
    View in: PubMed
    Score: 0.023
  83. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet. 2007 Sep 19; 8 Suppl 1:S2.
    View in: PubMed
    Score: 0.023
  84. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007 Sep 11; 116(11):1234-41.
    View in: PubMed
    Score: 0.023
  85. Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study. Hypertension. 2007 Jun; 49(6):1285-90.
    View in: PubMed
    Score: 0.022
  86. Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample. Hypertension. 2007 Apr; 49(4):846-56.
    View in: PubMed
    Score: 0.022
  87. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet. 2007; 8 Suppl 1:S1.
    View in: PubMed
    Score: 0.022
  88. PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample. Obesity (Silver Spring). 2006 May; 14(5):753-8.
    View in: PubMed
    Score: 0.021
  89. Aging syndrome genes and premature coronary artery disease. BMC Med Genet. 2005 Oct 31; 6:38.
    View in: PubMed
    Score: 0.020
  90. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation. 2005 Aug 23; 112(8):1113-20.
    View in: PubMed
    Score: 0.020
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.