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profileChristopher Joseph O'Donnell, M.D.

TitleAssociate Professor of Medicine, Part-time
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressNational Heart, Lung and Blood Inst
Framingham Heart Study, #2
73 Mount Wayte Ave
Framingham MA 01702
Phone508/935-3435
Fax508/626-1262
vCardDownload vCard (login for email)

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Available: 07/01/17, Expires: 08/31/19

Dr. O’Donnell conducts his research through his role as Chief Scientist of the Veteran's Administration Million Veteran Program, a mega-biobank that has enrolled over 500,000 Veteran participants with extensive genotype and DNA sequence and clinical phenotype data. He is also a senior investigator associated with the National Heart, Lung and Blood Institute's Framingham Heart Study, in which detailed clinical phenotyping has been completed and genomewide scans of single nucleotide polymorphisms, exome/whole genome sequencing, transcriptome profiling and RNA sequencing has been completed. In collaboration with multiple other cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and the Exome Sequencing Program, Dr. O'Donnell directs studies of the genetic determinants of subclinical atherosclerosis, clinical coronary heart disease, thrombosis and hemostasis and coronary heart disease risk factors. He has been director and principal investigator of a large study of multidetector computed tomography imaging in two generations of family members to study coronary and aortic atherosclerosis. He is VA Principle Investigator of the national Precision Medicine Initiative All of Us Program and a Co-Investigator in the American Heart Association One Brave idea Program. A number of student projects are possible using data from these various projects and programs.


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC. Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun. 2017 Aug 02; 8:16140. PMID: 28767105.
    View in: PubMed
  2. O'Donnell CJ. Harnessing Genomic Biobanks to Understand Obesity in Cardiometabolic Disease: Prospects and Pitfalls. JAMA Cardiol. 2017 Aug 01; 2(8):889. PMID: 28678996.
    View in: PubMed
  3. Roseman DA, Hwang SJ, Oyama-Manabe N, Chuang ML, O'Donnell CJ, Manning WJ, Fox CS. Clinical associations of total kidney volume: the Framingham Heart Study. Nephrol Dial Transplant. 2017 Aug 01; 32(8):1344-1350. PMID: 27325252.
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  4. Yano Y, O'Donnell CJ, Kuller L, Kavousi M, Erbel R, Ning H, D'Agostino R, Newman AB, Nasir K, Hofman A, Lehmann N, Dhana K, Blankstein R, Hoffmann U, Möhlenkamp S, Massaro JM, Mahabadi AA, Lima JAC, Ikram MA, Jöckel KH, Franco OH, Liu K, Lloyd-Jones D, Greenland P. Association of Coronary Artery Calcium Score vs Age With Cardiovascular Risk in Older Adults: An Analysis of Pooled Population-Based Studies. JAMA Cardiol. 2017 Jul 26. PMID: 28746709.
    View in: PubMed
  5. Seyerle AA, Sitlani CM, Noordam R, Gogarten SM, Li J, Li X, Evans DS, Sun F, Laaksonen MA, Isaacs A, Kristiansson K, Highland HM, Stewart JD, Harris TB, Trompet S, Bis JC, Peloso GM, Brody JA, Broer L, Busch EL, Duan Q, Stilp AM, O'Donnell CJ, Macfarlane PW, Floyd JS, Kors JA, Lin HJ, Li-Gao R, Sofer T, Méndez-Giráldez R, Cummings SR, Heckbert SR, Hofman A, Ford I, Li Y, Launer LJ, Porthan K, Newton-Cheh C, Napier MD, Kerr KF, Reiner AP, Rice KM, Roach J, Buckley BM, Soliman EZ, de Mutsert R, Sotoodehnia N, Uitterlinden AG, North KE, Lee CR, Gudnason V, Stürmer T, Rosendaal FR, Taylor KD, Wiggins KL, Wilson JG, Chen YD, Kaplan RC, Wilhelmsen K, Cupples LA, Salomaa V, van Duijn C, Jukema JW, Liu Y, Mook-Kanamori DO, Lange LA, Vasan RS, Smith AV, Stricker BH, Laurie CC, Rotter JI, Whitsel EA, Psaty BM, Avery CL. Pharmacogenomics study of thiazide diuretics and QT interval in multi-ethnic populations: the cohorts for heart and aging research in genomic epidemiology. Pharmacogenomics J. 2017 Jul 18. PMID: 28719597.
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  6. Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O'Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 Sep; 49(9):1373-1384. PMID: 28714976.
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  7. Pursnani A, Massaro JM, D'Agostino RB, O'Donnell CJ, Hoffmann U. Guideline-Based Statin Eligibility, Cancer Events, and Noncardiovascular Mortality in the Framingham Heart Study. J Clin Oncol. 2017 Sep 01; 35(25):2927-2933. PMID: 28700275.
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  8. Aparicio HJ, Petrea RE, Massaro JM, Manning WJ, Oyama-Manabe N, Beiser AS, Kase CS, D'Agostino RB, Wolf PA, Vasan RS, DeCarli C, O'Donnell CJ, Seshadri S. Association of descending thoracic aortic plaque with brain atrophy and white matter hyperintensities: The Framingham Heart Study. Atherosclerosis. 2017 Jun 23. PMID: 28673480.
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  9. Afshar M, Luk K, Do R, Dufresne L, Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q, Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich SS, Engert JC, Gudnason V, O'Donnell CJ, Post WS, Thanassoulis G. Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification. J Am Coll Cardiol. 2017 Jun 20; 69(24):2941-2948. PMID: 28619195.
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  10. van den Berg ME, Warren HR, Cabrera CP, Verweij N, Mifsud B, Haessler J, Bihlmeyer NA, Fu YP, Weiss S, Lin HJ, Grarup N, Li-Gao R, Pistis G, Shah N, Brody JA, Müller-Nurasyid M, Lin H, Mei H, Smith AV, Lyytikäinen LP, Hall LM, van Setten J, Trompet S, Prins BP, Isaacs A, Radmanesh F, Marten J, Entwistle A, Kors JA, Silva CT, Alonso A, Bis JC, de Boer R, de Haan HG, de Mutsert R, Dedoussis G, Dominiczak AF, Doney ASF, Ellinor PT, Eppinga RN, Felix SB, Guo X, Hagemeijer Y, Hansen T, Harris TB, Heckbert SR, Huang PL, Hwang SJ, Kähönen M, Kanters JK, Kolcic I, Launer LJ, Li M, Yao J, Linneberg A, Liu S, Macfarlane PW, Mangino M, Morris AD, Mulas A, Murray AD, Nelson CP, Orrú M, Padmanabhan S, Peters A, Porteous DJ, Poulter N, Psaty BM, Qi L, Raitakari OT, Rivadeneira F, Roselli C, Rudan I, Sattar N, Sever P, Sinner MF, Soliman EZ, Spector TD, Stanton AV, Stirrups KE, Taylor KD, Tobin MD, Uitterlinden A, Vaartjes I, Hoes AW, van der Meer P, Völker U, Waldenberger M, Xie Z, Zoledziewska M, Tinker A, Polasek O, Rosand J, Jamshidi Y, van Duijn CM, Zeggini E, Jukema JW, Asselbergs FW, Samani NJ, Lehtimäki T, Gudnason V, Wilson J, Lubitz SA, Kääb S, Sotoodehnia N, Caulfield MJ, Palmer CNA, Sanna S, Mook-Kanamori DO, Deloukas P, Pedersen O, Rotter JI, Dörr M, O'Donnell CJ, Hayward C, Arking DE, Kooperberg C, van der Harst P, Eijgelsheim M, Stricker BH, Munroe PB. Discovery of novel heart rate-associated loci using the Exome Chip. Hum Mol Genet. 2017 Jun 15; 26(12):2346-2363. PMID: 28379579.
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  11. Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC. Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun. 2017 Jun 14; 8:15805. PMID: 28613276.
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  12. Hernandez AF, Harrington RA, O'Donnell CJ. Integrating Research With Clinical Practice: Keeping It Simple. JAMA Cardiol. 2017 Jun 01; 2(6):616. PMID: 28384692.
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  13. Song C, Burgess S, Eicher JD, O'Donnell CJ, Johnson AD. Causal Effect of Plasminogen Activator Inhibitor Type 1 on Coronary Heart Disease. J Am Heart Assoc. 2017 May 26; 6(6). PMID: 28550093.
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  14. Higgins S, Parsons S, Woodford N, Lynch M, Briggs C, O'Donnell C. The effect of post-mortem computed tomography angiography (PMCTA) using water-soluble, iodine-based radiographic contrast on histological analysis of the liver, kidneys and left ventricle of the heart. Forensic Sci Med Pathol. 2017 May 20. PMID: 28526950.
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  15. Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MH, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 2017 Apr 06; 20(4):547-557.e7. PMID: 28388431.
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  16. Haitjema S, Meddens CA, van der Laan SW, Kofink D, Harakalova M, Tragante V, Foroughi Asl H, van Setten J, Brandt MM, Bis JC, O'Donnell C, Cheng C, Hoefer IE, Waltenberger J, Biessen E, Jukema JW, Doevendans PA, Nieuwenhuis EE, Erdmann J, Björkegren JL, Pasterkamp G, Asselbergs FW, den Ruijter HM, Mokry M. Additional Candidate Genes for Human Atherosclerotic Disease Identified Through Annotation Based on Chromatin Organization. Circ Cardiovasc Genet. 2017 Apr; 10(2). PMID: 28320757.
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  17. Dorans KS, Wilker EH, Li W, Rice MB, Ljungman PL, Schwartz J, Coull BA, Kloog I, Koutrakis P, D'Agostino RB, Massaro JM, Hoffmann U, O'Donnell CJ, Mittleman MA. Residential proximity to major roads, exposure to fine particulate matter and aortic calcium: the Framingham Heart Study, a cohort study. BMJ Open. 2017 Mar 16; 7(3):e013455. PMID: 28302634.
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  18. McMahon GM, Hwang SJ, Clish CB, Tin A, Yang Q, Larson MG, Rhee EP, Li M, Levy D, O'Donnell CJ, Coresh J, Young JH, Gerszten RE, Fox CS. Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease. Kidney Int. 2017 Jun; 91(6):1426-1435. PMID: 28302371.
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  19. Goettsch C, Iwata H, Hutcheson JD, O'Donnell CJ, Chapurlat R, Cook NR, Aikawa M, Szulc P, Aikawa E. Serum Sortilin Associates With Aortic Calcification and Cardiovascular Risk in Men. Arterioscler Thromb Vasc Biol. 2017 May; 37(5):1005-1011. PMID: 28279970.
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  20. Onuma OK, Pencina K, Qazi S, Massaro JM, D'Agostino RB, Chuang ML, Fox CS, Hoffmann U, O'Donnell CJ. Relation of Risk Factors and Abdominal Aortic Calcium to Progression of Coronary Artery Calcium (from the Framingham Heart Study). Am J Cardiol. 2017 May 15; 119(10):1584-1589. PMID: 28442125.
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  21. Joehanes R, Zhang X, Huan T, Yao C, Ying SX, Nguyen QT, Demirkale CY, Feolo ML, Sharopova NR, Sturcke A, Schäffer AA, Heard-Costa N, Chen H, Liu PC, Wang R, Woodhouse KA, Tanriverdi K, Freedman JE, Raghavachari N, Dupuis J, Johnson AD, O'Donnell CJ, Levy D, Munson PJ. Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies. Genome Biol. 2017 Jan 25; 18(1):16. PMID: 28122634.
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  22. Puurunen MK, Hwang SJ, O'Donnell CJ, Tofler G, Johnson AD. Platelet function as a risk factor for venous thromboembolism in the Framingham Heart Study. Thromb Res. 2017 Mar; 151:57-62. PMID: 28152437.
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  23. de Vries PS, Sabater-Lleal M, Chasman DI, Trompet S, Ahluwalia TS, Teumer A, Kleber ME, Chen MH, Wang JJ, Attia JR, Marioni RE, Steri M, Weng LC, Pool R, Grossmann V, Brody JA, Venturini C, Tanaka T, Rose LM, Oldmeadow C, Mazur J, Basu S, Frånberg M, Yang Q, Ligthart S, Hottenga JJ, Rumley A, Mulas A, de Craen AJ, Grotevendt A, Taylor KD, Delgado GE, Kifley A, Lopez LM, Berentzen TL, Mangino M, Bandinelli S, Morrison AC, Hamsten A, Tofler G, de Maat MP, Draisma HH, Lowe GD, Zoledziewska M, Sattar N, Lackner KJ, Völker U, McKnight B, Huang J, Holliday EG, McEvoy MA, Starr JM, Hysi PG, Hernandez DG, Guan W, Rivadeneira F, McArdle WL, Slagboom PE, Zeller T, Psaty BM, Uitterlinden AG, de Geus EJ, Stott DJ, Binder H, Hofman A, Franco OH, Rotter JI, Ferrucci L, Spector TD, Deary IJ, März W, Greinacher A, Wild PS, Cucca F, Boomsma DI, Watkins H, Tang W, Ridker PM, Jukema JW, Scott RJ, Mitchell P, Hansen T, O'Donnell CJ, Smith NL, Strachan DP, Dehghan A. Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PLoS One. 2017; 12(1):e0167742. PMID: 28107422.
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  24. Zhu QM, Ko KA, Ture S, Mastrangelo MA, Chen MH, Johnson AD, O'Donnell CJ, Morrell CN, Miano JM, Lowenstein CJ. Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice. Arterioscler Thromb Vasc Biol. 2017 Feb; 37(2):264-270. PMID: 28062498.
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  25. van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH, Ridker PM, Tang H, Launer LJ, Rice KM, Li-Gao R, Ferrucci L, Evans MK, Choudhuri A, Trompouki E, Abraham BJ, Yang S, Takahashi A, Kamatani Y, Kooperberg C, Harris TB, Jee SH, Coresh J, Tsai FJ, Longo DL, Chen YT, Felix JF, Yang Q, Psaty BM, Boerwinkle E, Becker LC, Mook-Kanamori DO, Wilson JG, Gudnason V, O'Donnell CJ, Dehghan A, Cupples LA, Nalls MA, Morris AP, Okada Y, Reiner AP, Zon LI, Ganesh SK. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 05; 100(1):51-63. PMID: 28017375.
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  26. Morrison AC, Fu YP, O'Donnell CJ. Variants in ANGPTL4 and the Risk of Coronary Artery Disease. N Engl J Med. 2016 12 08; 375(23):2303. PMID: 27959691.
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  27. Kavousi M, Desai CS, Ayers C, Blumenthal RS, Budoff MJ, Mahabadi AA, Ikram MA, van der Lugt A, Hofman A, Erbel R, Khera A, Geisel MH, Jöckel KH, Lehmann N, Hoffmann U, O'Donnell CJ, Massaro JM, Liu K, Möhlenkamp S, Ning H, Franco OH, Greenland P. Prevalence and Prognostic Implications of Coronary Artery Calcification in Low-Risk Women: A Meta-analysis. JAMA. 2016 Nov 22; 316(20):2126-2134. PMID: 27846641.
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  337. Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, O'Donnell CJ, Cupples LA, Meigs JB. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 2008 Dec; 57(12):3353-9. PMID: 18776141; PMCID: PMC2584143.
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  339. Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SL. Vitamin K, circulating cytokines, and bone mineral density in older men and women. Am J Clin Nutr. 2008 Aug; 88(2):356-63. PMID: 18689371; PMCID: PMC2532855.
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  348. Levitzky YS, Cupples LA, Murabito JM, Kannel WB, Kiel DP, Wilson PW, Wolf PA, O'Donnell CJ. Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs. Am J Cardiol. 2008 Feb 01; 101(3):326-31. PMID: 18237594.
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  351. Govindaraju DR, Cupples LA, Kannel WB, O'Donnell CJ, Atwood LD, D'Agostino RB, Fox CS, Larson M, Levy D, Murabito J, Vasan RS, Splansky GL, Wolf PA, Benjamin EJ. Genetics of the Framingham Heart Study population. Adv Genet. 2008; 62:33-65. PMID: 19010253; PMCID: PMC3014216.
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  353. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y. Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008 Jan 29; 117(4):e25-146. PMID: 18086926.
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  356. Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP. Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. J Physiol. 2008 Feb 01; 586(3):899-911. PMID: 18033815; PMCID: PMC2375607.
  357. Shea MK, Benjamin EJ, Dupuis J, Massaro JM, Jacques PF, D'Agostino RB, Ordovas JM, O'Donnell CJ, Dawson-Hughes B, Vasan RS, Booth SL. Genetic and non-genetic correlates of vitamins K and D. Eur J Clin Nutr. 2009 Apr; 63(4):458-64. PMID: 18030310; PMCID: PMC2681093.
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  365. Parikh NI, Hwang SJ, Larson MG, Cupples LA, Fox CS, Manders ES, Murabito JM, Massaro JM, Hoffmann U, O'Donnell CJ. Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts. Circulation. 2007 Sep 25; 116(13):1473-81. PMID: 17785619.
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  366. Samelson EJ, Cupples LA, Broe KE, Hannan MT, O'Donnell CJ, Kiel DP. Vascular calcification in middle age and long-term risk of hip fracture: the Framingham Study. J Bone Miner Res. 2007 Sep; 22(9):1449-54. PMID: 17542685; PMCID: PMC2748402.
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  368. Newton-Cheh C, Guo CY, Larson MG, Musone SL, Surti A, Camargo AL, Drake JA, Benjamin EJ, Levy D, D'Agostino RB, Hirschhorn JN, O'donnell CJ. Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study. Circulation. 2007 Sep 04; 116(10):1128-36. PMID: 17709632.
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  369. Ingelsson E, Sullivan LM, Fox CS, Murabito JM, Benjamin EJ, Polak JF, Meigs JB, Keyes MJ, O'Donnell CJ, Wang TJ, D'Agostino RB, Wolf PA, Vasan RS. Burden and prognostic importance of subclinical cardiovascular disease in overweight and obese individuals. Circulation. 2007 Jul 24; 116(4):375-84. PMID: 17620505.
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  374. Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, Vasan RS, D'Agostino RB, Lipinska I, Keaney JF, Benjamin EJ, O'Donnell CJ. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol. 2007 Jun 01; 99(11):1598-602. PMID: 17531588.
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  380. Minoguchi K, Yokoe T, Tazaki T, Minoguchi H, Oda N, Tanaka A, Yamamoto M, Ohta S, O'Donnell CP, Adachi M. Silent brain infarction and platelet activation in obstructive sleep apnea. Am J Respir Crit Care Med. 2007 Mar 15; 175(6):612-7. PMID: 17341649.
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  381. Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros ME, Avila L, Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61. PMID: 17465681; PMCID: PMC1857727.
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  383. Dupuis J, O'Donnell CJ. Interpreting results of large-scale genetic association studies: separating gold from fool's gold. JAMA. 2007 Feb 07; 297(5):529-31. PMID: 17284705.
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  384. Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):851-7. PMID: 17272786; PMCID: PMC1899294.
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  386. Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet. 2007; 8 Suppl 1:S1. PMID: 17903291; PMCID: PMC1995613.
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  388. Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell CJ, Roger V, Rumsfeld J, Sorlie P, Steinberger J, Thom T, Wasserthiel-Smoller S, Hong Y. Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007 Feb 06; 115(5):e69-171. PMID: 17194875.
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  389. Goff DC, Brass L, Braun LT, Croft JB, Flesch JD, Fowkes FG, Hong Y, Howard V, Huston S, Jencks SF, Luepker R, Manolio T, O'Donnell C, Robertson RM, Rosamond W, Rumsfeld J, Sidney S, Zheng ZJ. Essential features of a surveillance system to support the prevention and management of heart disease and stroke: a scientific statement from the American Heart Association Councils on Epidemiology and Prevention, Stroke, and Cardiovascular Nursing and the Interdisciplinary Working Groups on Quality of Care and Outcomes Research and Atherosclerotic Peripheral Vascular Disease. Circulation. 2007 Jan 02; 115(1):127-55. PMID: 17179025.
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  390. Kathiresan S, Larson MG, Keyes MJ, Polak JF, Wolf PA, D'Agostino RB, Jaffer FA, Clouse ME, Levy D, Manning WJ, O'Donnell CJ. Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata. Am J Cardiol. 2007 Feb 01; 99(3):310-4. PMID: 17261388.
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  394. Maurovich-Horvat P, Massaro J, Fox CS, Moselewski F, O'Donnell CJ, Hoffmann U. Comparison of anthropometric, area- and volume-based assessment of abdominal subcutaneous and visceral adipose tissue volumes using multi-detector computed tomography. Int J Obes (Lond). 2007 Mar; 31(3):500-6. PMID: 16953256.
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  395. Lee DS, Pencina MJ, Benjamin EJ, Wang TJ, Levy D, O'Donnell CJ, Nam BH, Larson MG, D'Agostino RB, Vasan RS. Association of parental heart failure with risk of heart failure in offspring. N Engl J Med. 2006 Jul 13; 355(2):138-47. PMID: 16837677.
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  401. Kathiresan S, Yang Q, Larson MG, Camargo AL, Tofler GH, Hirschhorn JN, Gabriel SB, O'Donnell CJ. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1405-12. PMID: 16614319.
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  405. Elosua R, Ordovas JM, Cupples LA, Lai CQ, Demissie S, Fox CS, Polak JF, Wolf PA, D'Agostino RB, O'Donnell CJ. Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study. J Lipid Res. 2006 May; 47(5):990-6. PMID: 16474174.
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  406. Meigs JB, O'donnell CJ, Tofler GH, Benjamin EJ, Fox CS, Lipinska I, Nathan DM, Sullivan LM, D'Agostino RB, Wilson PW. Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the Framingham Offspring Study. Diabetes. 2006 Feb; 55(2):530-7. PMID: 16443791.
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  407. Hoffmann U, Siebert U, Bull-Stewart A, Achenbach S, Ferencik M, Moselewski F, Brady TJ, Massaro JM, O'Donnell CJ. Evidence for lower variability of coronary artery calcium mineral mass measurements by multi-detector computed tomography in a community-based cohort--consequences for progression studies. Eur J Radiol. 2006 Mar; 57(3):396-402. PMID: 16434160.
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  408. Elosua R, Cupples LA, Fox CS, Polak JF, D'Agostino RA, Wolf PA, O'Donnell CJ, Ordovas JM. Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study. Atherosclerosis. 2006 Nov; 189(1):222-8. PMID: 16430904.
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  409. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O'Donnell C, Kittner S, Lloyd-Jones D, Goff DC, Hong Y, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M, Wolf P. Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006 Feb 14; 113(6):e85-151. PMID: 16407573.
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  410. Karasik D, Kiel DP, Kiely DK, Cupples LA, Wilson PW, O'Donnell CJ, Felson DT. Abdominal aortic calcification and exostoses at the hand and lumbar spine: the Framingham Study. Calcif Tissue Int. 2006 Jan; 78(1):1-8. PMID: 16397734.
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  411. Murabito JM, Pencina MJ, Nam BH, D'Agostino RB, Wang TJ, Lloyd-Jones D, Wilson PW, O'Donnell CJ. Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults. JAMA. 2005 Dec 28; 294(24):3117-23. PMID: 16380592.
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  412. Fox CS, Larson MG, Vasan RS, Guo CY, Parise H, Levy D, Leip EP, O'donnell CJ, D'Agostino RB, Benjamin EJ. Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study. J Am Soc Nephrol. 2006 Feb; 17(2):521-7. PMID: 16382018.
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  413. Wilson PW, Nam BH, Pencina M, D'Agostino RB, Benjamin EJ, O'Donnell CJ. C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med. 2005 Nov 28; 165(21):2473-8. PMID: 16314543.
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  414. Polotsky VY, Rubin AE, Balbir A, Dean T, Smith PL, Schwartz AR, O'Donnell CP. Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse. Sleep Med. 2006 Jan; 7(1):7-16. PMID: 16309961.
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  415. Low AF, O'Donnell CJ, Kathiresan S, Everett B, Chae CU, Shaw SY, Ellinor PT, MacRae CA. Aging syndrome genes and premature coronary artery disease. BMC Med Genet. 2005 Oct 31; 6:38. PMID: 16262891; PMCID: PMC1289285.
  416. Iiyori N, Shirahata M, O'Donnell CP. Genetic background affects cardiovascular responses to obstructive and simulated apnea. Physiol Genomics. 2005 Dec 14; 24(1):65-72. PMID: 16249313.
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  417. Kathiresan S, Gabriel SB, Yang Q, Lochner AL, Larson MG, Levy D, Tofler GH, Hirschhorn JN, O'Donnell CJ. Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels. Circulation. 2005 Sep 20; 112(12):1728-35. PMID: 16172282.
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  418. Ilkhanoff L, O'Donnell CJ, Camargo CA, O'Halloran TD, Giugliano RP, Lloyd-Jones DM. Usefulness of the TIMI Risk Index in predicting short- and long-term mortality in patients with acute coronary syndromes. Am J Cardiol. 2005 Sep 15; 96(6):773-7. PMID: 16169358.
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  419. Kathiresan S, Larson MG, Vasan RS, Guo CY, Vita JA, Mitchell GF, Keyes MJ, Newton-Cheh C, Musone SL, Lochner AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community. Circulation. 2005 Sep 06; 112(10):1419-27. PMID: 16129794.
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  420. Li J, Thorne LN, Punjabi NM, Sun CK, Schwartz AR, Smith PL, Marino RL, Rodriguez A, Hubbard WC, O'Donnell CP, Polotsky VY. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res. 2005 Sep 30; 97(7):698-706. PMID: 16123334.
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  421. McDermott DH, Yang Q, Kathiresan S, Cupples LA, Massaro JM, Keaney JF, Larson MG, Vasan RS, Hirschhorn JN, O'Donnell CJ, Murphy PM, Benjamin EJ. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation. 2005 Aug 23; 112(8):1113-20. PMID: 16116069.
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  422. Li J, Grigoryev DN, Ye SQ, Thorne L, Schwartz AR, Smith PL, O'Donnell CP, Polotsky VY. Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J Appl Physiol (1985). 2005 Nov; 99(5):1643-8. PMID: 16037401.
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  423. Moselewski F, O'Donnell CJ, Achenbach S, Ferencik M, Massaro J, Nguyen A, Cury RC, Abbara S, Jang IK, Brady TJ, Hoffmann U. Calcium concentration of individual coronary calcified plaques as measured by multidetector row computed tomography. Circulation. 2005 Jun 21; 111(24):3236-41. PMID: 15956133.
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  424. O'Donnell CJ. Translating the Human Genome Project into prevention of myocardial infarction and stroke--getting close? JAMA. 2005 May 11; 293(18):2277-9. PMID: 15886385.
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  425. Fox CS, Evans JC, Larson MG, Lloyd-Jones DM, O'Donnell CJ, Sorlie PD, Manolio TA, Kannel WB, Levy D. A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death. Am J Cardiol. 2005 Apr 01; 95(7):856-9. PMID: 15781015.
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  426. Newton-Cheh C, Larson MG, Corey DC, Benjamin EJ, Herbert AG, Levy D, D'Agostino RB, O'Donnell CJ. QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study. Heart Rhythm. 2005 Mar; 2(3):277-84. PMID: 15851319.
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  427. Lin JP, O'Donnell CJ, Levy D, Cupples LA. Evidence for a gene influencing haematocrit on chromosome 6q23-24: genomewide scan in the Framingham Heart Study. J Med Genet. 2005 Jan; 42(1):75-9. PMID: 15635079; PMCID: PMC1735909.
  428. Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation. 2005 Jan 04; 111(1):63-9. PMID: 15611369.
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  429. Fox CS, Larson MG, Keyes MJ, Levy D, Clouse ME, Culleton B, O'Donnell CJ. Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study. Kidney Int. 2004 Nov; 66(5):2017-21. PMID: 15496174.
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  430. Campen MJ, Tagaito Y, Li J, Balbir A, Tankersley CG, Smith P, Schwartz A, O'Donnell CP. Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice. Physiol Genomics. 2004 Dec 15; 20(1):15-20. PMID: 15494473.
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  431. O'Donnell CJ. Family history, subclinical atherosclerosis, and coronary heart disease risk: barriers and opportunities for the use of family history information in risk prediction and prevention. Circulation. 2004 Oct 12; 110(15):2074-6. PMID: 15477424.
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  432. Groeben H, Meier S, Brown RH, O'Donnell CP, Mitzner W, Tankersley CG. The effect of leptin on the ventilatory responseto hyperoxia. Exp Lung Res. 2004 Oct-Nov; 30(7):559-70. PMID: 15371092.
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  433. Balady GJ, Larson MG, Vasan RS, Leip EP, O'Donnell CJ, Levy D. Usefulness of exercise testing in the prediction of coronary disease risk among asymptomatic persons as a function of the Framingham risk score. Circulation. 2004 Oct 05; 110(14):1920-5. PMID: 15451778.
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  434. Cury RC, Ferencik M, Hoffmann U, Ferullo A, Moselewski F, Abbara S, Booth SL, O'Donnell CJ, Brady TJ, Achenbach S. Epidemiology and association of vascular and valvular calcium quantified by multidetector computed tomography in elderly asymptomatic subjects. Am J Cardiol. 2004 Aug 01; 94(3):348-51. PMID: 15276102.
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  435. Elosua R, Ordovas JM, Cupples LA, Fox CS, Polak JF, Wolf PA, D'Agostino RA, O'Donnell CJ. Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study. J Lipid Res. 2004 Oct; 45(10):1868-75. PMID: 15258198.
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  436. Manolio TA, Boerwinkle E, O'Donnell CJ, Wilson AF. Genetics of ultrasonographic carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1567-77. PMID: 15256397.
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  437. Newton-Cheh C, Larson M, Kathiresan S, O'Donnell C. On the significance of linkage studies of complex traits. Am J Hum Genet. 2004 Jul; 75(1):151-2; author reply 152-4. PMID: 15164311; PMCID: PMC1181999.
  438. Newton-Cheh C, O'Donnell CJ. Sex differences and genetic associations with myocardial infarction. JAMA. 2004 Jun 23; 291(24):3008-10. PMID: 15213215.
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  439. Haider AW, Roubenoff R, Wilson PW, Levy D, D'Agostino R, Silbershatz H, O'Donnell CJ. Monocyte cytokine production, systemic inflammation and cardiovascular disease in very elderly men and women: the Framingham Heart Study. Eur J Cardiovasc Prev Rehabil. 2004 Jun; 11(3):214-5. PMID: 15179102.
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  440. Allen LA, O'Donnell CJ, Giugliano RP, Camargo CA, Lloyd-Jones DM. Care concordant with guidelines predicts decreased long-term mortality in patients with unstable angina pectoris and non-ST-elevation myocardial infarction. Am J Cardiol. 2004 May 15; 93(10):1218-22. PMID: 15135692.
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  441. Lloyd-Jones DM, Nam BH, D'Agostino RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA. 2004 May 12; 291(18):2204-11. PMID: 15138242.
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  442. Fox CS, Parise H, Vasan RS, Levy D, O'Donnell CJ, D'Agostino RB, Plehn JF, Benjamin EJ. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis. 2004 Apr; 173(2):291-4. PMID: 15064104.
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  443. Murabito JM, Nam BH, D'Agostino RB, Lloyd-Jones DM, O'Donnell CJ, Wilson PW. Accuracy of offspring reports of parental cardiovascular disease history: the Framingham Offspring Study. Ann Intern Med. 2004 Mar 16; 140(6):434-40. PMID: 15023709.
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  444. Walsh CR, Larson MG, Kupka MJ, Levy D, Vasan RS, Benjamin EJ, Manning WJ, Clouse ME, O'Donnell CJ. Association of aortic valve calcium detected by electron beam computed tomography with echocardiographic aortic valve disease and with calcium deposits in the coronary arteries and thoracic aorta. Am J Cardiol. 2004 Feb 15; 93(4):421-5. PMID: 14969614.
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  445. Fox CS, Larson MG, Corey D, Feng D, Lindpaintner K, Polak JF, Wolf PA, D'Agostino RB, Tofler GH, O'Donnell CJ. Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study. Stroke. 2004 Mar; 35(3):e65-7. PMID: 14963283.
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  446. Fox CS, Cupples LA, Chazaro I, Polak JF, Wolf PA, D'Agostino RB, Ordovas JM, O'Donnell CJ. Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. Am J Hum Genet. 2004 Feb; 74(2):253-61. PMID: 14730480; PMCID: PMC1181923.
  447. Macrae C, O'donnell CJ. Current and Future Impact of Genomics on the Diagnosis and Management of Cardiovascular Disease. Principles of Molecular Medicine. 2004; In Press.
  448. Ellsworth DL, O'Donnell CJ. Emerging Genomic Technologies and Analytic Methods for Population-and Clinic-Based Research. Human Genome Epidemiology: a Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease. 2004; Chapter 2.
  449. Lloyd-Jones DM, O'Donnell CJ. Hypertension as a Risk Factor for Stroke: Edpidemiology of Blood Pressure Risks and Evidence for Treatment Benefits. Handbook of Stroke Prevention. 2004; In Press.
  450. O'Donnell Cj, Hoffman U. Coronary calcium Screening; An Epidemiologic Perspective. CT of the Heart: Principles and Applications. 2004; In Press.
  451. Lloyd-Jones DM, Camargo CA, Allen LA, Giugliano RP, O'Donnell CJ. Predictors of Long-term Mortality After Hospitalization for Primary Unstable Angina PLectoris and Non-ST-Elevation Myocardial Infarction. American Journal of Cardiology. 2003; 92(10):1155-1159.
  452. Lloyd-Jones DM, Camargo CA, Allen LA, Giugliano RP, O'Donnell CJ. Predictors of long-term mortality after hospitalization for primary unstable angina pectoris and non-ST-elevation myocardial infarction. Am J Cardiol. 2003 Nov 15; 92(10):1155-9. PMID: 14609588.
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  453. Polotsky VY, Smaldone MC, Scharf MT, Li J, Tankersley CG, Smith PL, Schwartz AR, O'Donnell CP. Impact of interrupted leptin pathways on ventilatory control. J Appl Physiol (1985). 2004 Mar; 96(3):991-8. PMID: 14578371.
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  454. Drake J, Loomer M, Newton-Cheh C, Lochner A, Levy R, Parise H, Schaffner SF, Gabriel S, Larson M, Benjamin EJ, Daly MJ, O'Donnell CJ, Hirschhorn JN. Efficacy of haplotype-based association approaches. American Journal of Human Genetics. 2003; 108(387).
  455. Cohen RI, Marzouk K, Berkoski P, O'Donnell CP, Polotsky VY, Scharf SM. Body composition and resting energy expenditure in clinically stable, non-weight-losing patients with severe emphysema. Chest. 2003 Oct; 124(4):1365-72. PMID: 14555567.
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  456. Rubin AE, Polotsky VY, Balbir A, Krishnan JA, Schwartz AR, Smith PL, Fitzgerald RS, Tankersley CG, Shirahata M, O'Donnell CP. Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains. Am J Respir Crit Care Med. 2003 Dec 15; 168(12):1520-7. PMID: 14512266.
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  457. Barouch LA, Berkowitz DE, Harrison RW, O'Donnell CP, Hare JM. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation. 2003 Aug 12; 108(6):754-9. PMID: 12885755.
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  458. Polotsky VY, Li J, Punjabi NM, Rubin AE, Smith PL, Schwartz AR, O'Donnell CP. Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol. 2003 Oct 01; 552(Pt 1):253-64. PMID: 12878760; PMCID: PMC2343324.
  459. Wang TJ, Nam BH, D'Agostino RB, Wolf PA, Lloyd-Jones DM, MacRae CA, Wilson PW, Polak JF, O'Donnell CJ. Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study. Circulation. 2003 Aug 05; 108(5):572-6. PMID: 12874190.
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  460. Punjabi NM, Ahmed MM, Polotsky VY, Beamer BA, O'Donnell CP. Sleep-disordered breathing, glucose intolerance, and insulin resistance. Respir Physiol Neurobiol. 2003 Jul 16; 136(2-3):167-78. PMID: 12853008.
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  461. Ilkhanoff L, O'donnell CJ, Camargo CA, O'Halloran D, Giugliano RP, Lloyd-Jones DM. The TIMI Risk Index Predicts In-hospital and Long-term Mortality in Unselected Patients with Myocardial Infarction. Academy of Emergency Medicine. 2003; 10(5):429-430.
  462. Fox CS, Larson MG, Kupka MJ, Levy D, Clouse M, Culleton B, O'Donnell CJ. Reduced kidney function is associated with subclinical coronary artery calcification: The Framingham Heart Study. Circulation. 2003; 108:IV-730.
  463. Morita H. for the Cardiogenomics Group. Sarcomere protein gene and cardiac hypertrophy in the general population: The Framingham Heart Study. Circulation. 2003; 108:IV-50.
  464. O'Donnell CJ, Yang Q, Lochner A, Larson MG, Kathiresan S, Tofler GH, Gabriel SB. LAssociations of haplotypes of fibrinogen beta, alpha and gamma chain genes on chromosome 4 with circulating fibrinogen levels in men and women. Circulation. 2003; 108:IV-771.
  465. Wilson PW, D'Agostino RB, Nam BH, Benjamin EJ, O'Donnell CJ. C-reactive protein and CVD risk in Framingham. Circulation. 2003; 108:IV-748.
  466. Hoffman U, Bull-Stewart A, Achenbach S, Ferencik M, Brady TJ, O'Donnell CJ. Interscan and interobserver variability of coronary artery calcium measurements in prospectively triggered multislice computed tomography. Circulation. 2003; 108:IV-730.
  467. Fox CS, Evans JC, Larson MG, Sorlie PD, Manolio TA, Lloyd-Jones DM, Kannel W, O'Donnell CJ, Levy D. Death Certificate out-of-hospital cardiac death over estimates sudden cardiac death. Circulation. 2003; 108:IV-318.
  468. Lloyd-Jones DM, Nam BH, D'Agostino RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ. Parental history of cardiovascular disease adds predictive information to traditional risk factors and multivariate predicted risk. Circulation. 2003; 108:IV-730.
  469. Gurkan OU, O'Donnell C, Brower R, Ruckdeschel E, Becker PM. Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L710-8. PMID: 12754185.
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  470. Yang Q, Tofler GH, Cupples LA, Larson MG, Feng D, Lindpaintner K, Levy D, D'Agostino RB, O'Donnell CJ. A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study. Thromb Res. 2003 Apr 15; 110(1):57-64. PMID: 12877910.
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  471. McDermott DH, Fong AM, Yang Q, Sechler JM, Cupples LA, Merrell MN, Wilson PW, D'Agostino RB, O'Donnell CJ, Patel DD, Murphy PM. Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans. J Clin Invest. 2003 Apr; 111(8):1241-50. PMID: 12697743; PMCID: PMC152935.
  472. Fox CS, Parise H, Vasan RS, Levy D, O'Donnell CJ, D'Agostino RB Sr, Benjamin EJ. Mitral Annular Calcification is Associated with Incident Atrial Fibrillation and All-Cause Mortality: The Framingham Heart Study. Circulation. 2003; 107(11):1492-1496.
  473. Fox CS, Vasan RS, Parise H, Levy D, O'Donnell CJ, D'Agostino RB, Benjamin EJ. Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study. Circulation. 2003 Mar 25; 107(11):1492-6. PMID: 12654605.
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  474. O'Halloran D, O'Donnell CJ, Giugliano RP, Camargo CA, Allen L, Lloyd-Jones DM. The TIMI risk index predicts long-term mortality in patients admitted with primary unstable angina. American College of Cardiology Scientific Sessions. 2003.
  475. Smith PL, O'Donnell CP, Allan L, Schwartz AR. A physiologic comparison of nasal and oral positive airway pressure. Chest. 2003 Mar; 123(3):689-94. PMID: 12628864.
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  476. Lin JP, Cupples LA, Wilson PW, Heard-Costa N, O'Donnell CJ. Evidence for a gene influencing serum bilirubin on chromosome 2q telomere: a genomewide scan in the Framingham study. Am J Hum Genet. 2003 Apr; 72(4):1029-34. PMID: 12618960; PMCID: PMC1180333.
  477. Fox CS, Polak JF, Chazaro I, Cupples A, Wolf PA, D'Agostino RA, O'Donnell CJ. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke. 2003 Feb; 34(2):397-401. PMID: 12574549.
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  478. Fox C, Polak JF, Chazaro I, Cupples A, Wolf PA, D'Agostino R, O'Donnell CJ. . Carotid Intimal Medial Thickness is a Heritable Phenotype: The Framingham Heart Study. Stroke. 2003; 34(2):397-401.
  479. Morita H. For the Cardiogenomics Group. Sarcomere Protein Gene and Cardiac Hypertrophy in the General Population: The Framingham Heart Study. Circulation. 2003; 108:IV-50.
  480. Drake J, Loomer M, Newton-Cheh C, Lochner A, Levy R, Parise H, Schaffner SF, Gabriel S, Larson M, Benjamin EJ, Daly MJ, O'Donnell CJ, Hirschhorn JN. Efficacy of Haplotype-based Association Approaches. AJHG. 2003; 73(Supplement):387.
  481. Ilkhanoff L, O'Donnell CJ, Camargo CA, O'Halloran D, Giugliano RP, Lloyd-Jones DM. The TIMI Risk Index Predicts In-hospital and Long-term Mortality in Unselected Patients with Myocardial Infarction. Academy of Emergency Medicine. 2003; 10(5):429-430.
  482. Wilson PW, D'Agostino RB, Nam BH, Benjamin EJ, O'Donnell CJ. C-Reactive Protein and CVD Risk in Framingham. Circulation. 2003; 108:IV-748.
  483. Hoffman U, Bull-Stewart A, Achenbach S, Ferencik M, Brady TJ, O'Donnell CJ. Interscan and Interobserver Variability of Coronary Artery Calcium Measurements in Prospectively Triggered Multislice Computed Tomography. Circulation. 2003; 108:IV-529.
  484. O'Donnell CJ, Yang Q, Lochner A, Larson MG, Kathiresan S, Tofler GH, Gabriel SB. Associations of Haplotypes of Fibrinogen Beta, Alpha and Gamma Chain Genes on Chromosome 4 with Circulating Fibrinogen Levels in Mebn and Women. Circulation. 2003; 108:IV-771.
  485. O'Halloran D, O'Donnell CJ, Giugliano RP, Camargo CA, Allen L, Lloyd-Jones DM. The TIMI risk index predicts long-term mortality in patients admitted with primary unstable angina. American College of cardiology Scientific Sessions. 2003.
  486. Fox CS, Evans JC, Larson MG, Sorlie PD, Manolio TA, Lloyd-Jones DM, Kannel W, O'Donnell CJ, Levy D. Death Certificate Out-of-Hospital Cardiac Death Overestimates Sudden Cardiac Death. Circulation. 2003; 108:IV-318.
  487. Lloyd-Jones DM, Nam BH, D'Agostino RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ. Parental History of Cardiovascular Disease Adds Predictive Information to Traditional Risk Factors and Multivariate Predicted Risk. Circulation. 2003; 108:IV-725.
  488. Fox CS, Larsdon MG, Kupka MJ, Levy D, Clouse M, Culleton B, O'Donnell CJ. Reduced Kidney Function is Assiociated with Subclinical Coronary Artery Calcification: The Framingham Heart Study. Circulation. 2003; 108:IV-730.
  489. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Corey D, Levy D. Genome Scan Linkage Results for Heart Rate Variability in the Framingham Heart Study. American Journal of Cardiology. 2002; 90(12):1290-1293.
  490. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Corey D, Levy D. Genome scan linkage results for heart rate variability (the Framingham Heart Study). Am J Cardiol. 2002 Dec 15; 90(12):1290-3. PMID: 12480036.
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  491. Campen MJ, Tagaito Y, Jenkins TP, Smith PL, Schwartz AR, O'Donnell CP. Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice. Physiol Genomics. 2002 Dec 03; 11(3):227-34. PMID: 12388788.
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  492. Walsh CR, O'Donnell CJ, Camargo CA, Giugliano RP, Lloyd-Jones DM. Elevated serum creatinine is associated with 1-year mortality after acute myocardial infarction. Am Heart J. 2002 Dec; 144(6):1003-11. PMID: 12486424.
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  493. Loomer M, Gabriel SB, Platko J, O'Donnell C, Daly MJ, Lander ES, Hirschhorn JN. The efficacy of using haplotypes to assay common variation in genes. American Society of Human Genetics Annual Meeting. 2002.
  494. Lin JP, Cupples LA, Wilson PWF, Jaquish CE, O'Donnell CJ. Evidence for a Gene Influencing Serum Bilirubin on Chromosome 2qtelomere: a genome-wide scan in the Framingham Offspring Study. American Society of Human Genetics Annual Meeting. 2002.
  495. Haider AW, Wilson PW, Larson MG, Evans JC, Michelson EL, Wolf PA, O'Donnell CJ, Levy D. The association of seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective study. J Am Coll Cardiol. 2002 Oct 16; 40(8):1408-13. PMID: 12392829.
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  496. Morshedi-Meibodi A, Larson MG, Levy D, O'Donnell CJ, Vasan RS. Heart rate recovery after treadmill exercise testing and risk of cardiovascular disease events (The Framingham Heart Study). Am J Cardiol. 2002 Oct 15; 90(8):848-52. PMID: 12372572.
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  497. O'Donnell CP, Allan L, Atkinson P, Schwartz AR. The effect of upper airway obstruction and arousal on peripheral arterial tonometry in obstructive sleep apnea. Am J Respir Crit Care Med. 2002 Oct 01; 166(7):965-71. PMID: 12359655.
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  498. Schneider H, Boudewyns A, Smith PL, O'Donnell CP, Canisius S, Stammnitz A, Allan L, Schwartz AR. Modulation of upper airway collapsibility during sleep: influence of respiratory phase and flow regimen. J Appl Physiol (1985). 2002 Oct; 93(4):1365-76. PMID: 12235037.
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  499. Wang TJ, Nam BH, Wilson PW, Wolf PA, Levy D, Polak JF, D'Agostino RB, O'Donnell CJ. Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2002 Oct 01; 22(10):1662-7. PMID: 12377746.
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  500. Walsh CR, Cupples LA, Levy D, Kiel DP, Hannan M, Wilson PW, O'Donnell CJ. Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study. Am Heart J. 2002 Oct; 144(4):733-9. PMID: 12360172.
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  501. Wang TJ, Larson MG, Levy D, Benjamin EJ, Kupka MJ, Manning WJ, Clouse ME, D'Agostino RB, Wilson PW, O'Donnell CJ. C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study. Circulation. 2002 Sep 03; 106(10):1189-91. PMID: 12208790.
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  502. Meigs JB, Larson MG, D'Agostino RB, Levy D, Clouse ME, Nathan DM, Wilson PW, O'Donnell CJ. Coronary artery calcification in type 2 diabetes and insulin resistance: the framingham offspring study. Diabetes Care. 2002 Aug; 25(8):1313-9. PMID: 12145227.
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  503. O'Donnell CJ, Chazaro I, Wilson PW, Fox C, Hannan MT, Kiel DP, Cupples LA. Evidence for heritability of abdominal aortic calcific deposits in the Framingham Heart Study. Circulation. 2002 Jul 16; 106(3):337-41. PMID: 12119250.
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  504. O'Donnell CJ, Pasternak RC, O'Gara PT, Dec GW, Mort EA, Brady TJ. "Partner's summary of Current Clinical Evidence for Partner's Physicians: Statement on Coronary Calcium Screening for Coronary Disease Prevention". Brigham and Women's Hospital for Medical Professionals. 2002; (Statement on Coronary Calcium ).
  505. Fox CS, Parise H, Vasan RS, Levy D, O'Donnell CJ, D'Agostino RB Sr, Benjamin EJ. Mitral Annular Calcification Is Associated with Incident Agrial Fibarillation and All-Cause Mortality: The Framingham Heart Study. Circulation. 2002; 106:II-559.
  506. Lloyd-Jones DM, Nam B, D'Agostino RB Sr, Wilson PWF, Levy D, Murabito JM, O'Donnell CJ. Validated Parental History as a Risk Factor for Cardiovascular Disease. Circulation. 2002; 106:II-762.
  507. Allen LA, O'Donnell CJ, Giugliano RP, Camargo CA, Lloyd-Jones DM. Unstable Angina Guideline Concordance Predicts Decreased Mortality up to Ten Years after Hospitalization. Circulation. 2002; 106:II-762.
  508. Lloyd-Jones DM, Nam BH, D'Agostino RB Sr, Wilson PWF, Levy D, Murabito JM, O'Donnell CJ. Validated Parental History as a Risk Factor for Cardiovascular Disease. Circulation. 2002; 106:II-442.
  509. Jaffer FA, O'Donnell CJ, Larson MG, Chan SK, Kissinger KV, Kupka MJ, Salton C, Botnar RM, Levy D, Manning WJ. Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2002 May 01; 22(5):849-54. PMID: 12006401.
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  510. Maroo A, O'Donnell CJ. Current Practice and Future Promise for Clinical Noninvasive Measurements of Subclinical Atheroclerotic Disease in the Elderly. Americal Journal of Geriatric Cardiology. 2002; 11(2):108-116.
  511. Baim D, Brady TJ, Casscells SW, Dunne M, Fayad Z, Fuster V, Gazelle S, Heldman A, Hatsukami T, Kinlay S, Lafont A, Lee R, Libby P, Meier B, Muller JE, Naghavi M, O'Donnell C, Perin E, Rekhter M, Rumberger J, Russell M, Schwartz R, Selwyn A, Strauss HW, Tearney G, Tomaru T, Tuzcu EM, Wasserman B. Thoughts on the role of the healing professions and the events of September 11, 2001. Circulation. 2002 Mar 26; 105(12):1509-10. PMID: 11914263.
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  512. Salton CJ, Chuang ML, O'Donnell CJ, Kupka MJ, Larson MG, Kissinger KV, Edelman RR, Levy D, Manning WJ. Gender differences and normal left ventricular anatomy in an adult population free of hypertension. A cardiovascular magnetic resonance study of the Framingham Heart Study Offspring cohort. J Am Coll Cardiol. 2002 Mar 20; 39(6):1055-60. PMID: 11897450.
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  513. Maroo A, O'Donnell CJ. Current practice and future promise for clinical noninvasive measurements of subclinical atherosclerotic disease in the elderly. Am J Geriatr Cardiol. 2002 Mar-Apr; 11(2):108-16; quiz 116-8. PMID: 11872969.
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  514. O'Donnell CJ, Kannel WB. Epidemiologic appraisal of hypertension as a coronary risk factor in the elderly. Am J Geriatr Cardiol. 2002 Mar-Apr; 11(2):86-92. PMID: 11872966.
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  515. Allen LA, O'Donnell CJ, Giugliano RP, Camargo CA, Lloyd-Jones DM. Unstable Angina Guideline Concordance Predicts Decreased Mortality up to Ten-Years after Hospitalization. Circulation. 2002; 106:II-762.
  516. O'Donnell CJ, Kannell WB. Epidemiology of Atherosclerotic Vascular Disease. Pan Vascular Medicine: Integrated Clinical Management. 2002.
  517. Loomer M, Gabriel SB, Platko J, O'Donnell C, Daly MJ, Lander ES, Hirschhorn JN. The Efficacy of Using Haplotypes to Assay Common Variation in Genes. American Society of Human Genetics Annual Meeting. 2002.
  518. Chuang ML, Salton CL, O'Donnell CJ, Kissinger KV, Levy D, Manning WJ. Gender Differences in Detection of Concentric Left Ventricular Geometry by Magnetic Resonance Imaging. Society for Clinical Magnetic Resonance. 2002.
  519. Fox C, Polak JF, Chazaro I, Cupples A, Wolf PA, D'Agostino R, O'Donnell CJ. Carotid Intima-Media Thickness is a Heritable Phenotype: The Framingham Heart Study. Circulation. 2002; 105:E86-E119.
  520. Chuang ML, Salton CL, O'Donnell CJ, Kissinger KV, Levy D, Manning WJ. Gender Differences in Detection of Concentric Left Ventricular Geometry by Magnetic Resonance Imaging. Society for Clinical Magnetic Resonance. 2002.
  521. Chuang ML, Salton CL, O'Donnell CJ, Kissinger KV, Levy D, Manning WJ. Criteria for Concentric Left Ventricular Remodeling As Determined Using Magnetic Resonance Imaging. Journal of the American College of Cardiology. 2002; 39(5):368A.
  522. Murabito JM, Nam B, D'Agostino RA, Lloyd-Jones DM, O'Donnell CJ, Wilson PW. Accuracy of reported family history of cardiovascular disease and risk factors: The Framingham Offspring Study. Journal of General Internal Medicine. 2002; 17(S1):116.
  523. O'Donnell CJ, MacRae CA. Genetics of Cardiovascular Disease. In American College of Cardiology Self-Assessment Program V (ACCSAP V) 2002. American College of Cardiology. 2002; (Chapter 19):8-12.
  524. Tofler GH, Massaro J, Muller JE, Levy D, Mittleman MA, Lipinska I, Feng D, O'Donnell C, Wilson PW, D'Agostine RB. Hemostatic Predictors of Cardiovascular Disease: Prospective Evaluation of the Framingham Offspring Study. Journal of the American College of Cardiology. 2002.
  525. Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedman M, Metivier J, Cannata R, O'Donnell CJ, Kottke-Marchant K, Murugesan G, Plow EF, Stenina O, Daley GQ. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation. 2001 Nov 27; 104(22):2641-4. PMID: 11723011.
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  526. Vasan RS, Larson MG, Leip EP, Evans JC, O'Donnell CJ, Kannel WB, Levy D. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001 Nov 01; 345(18):1291-7. PMID: 11794147.
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  527. Singh JP, Larson MG, O'Donnell CJ, Levy D. Genetic factors contribute to the variance in frequency domain measures of heart rate variability. Auton Neurosci. 2001 Jul 20; 90(1-2):122-6. PMID: 11485278.
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  528. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, Mittleman M, Muller JE, D'Agostino RB, Levy D, Tofler GH. Platelet glycoprotein IIIa Pl(a) polymorphism, fibrinogen, and platelet aggregability: The Framingham Heart Study. Circulation. 2001 Jul 10; 104(2):140-4. PMID: 11447076.
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  529. Chan SK, Jaffer FA, Botnar RM, Kissinger KV, Goepfert L, Chuang ML, O'Donnell CJ, Levy D, Manning WJ. Scan Reproducibility of Magnetic Resonance Imaging Assessment of Aortic Atherosclerosis Burden. Journal of Cardiovascular Magnetic Resonance. 2001; 3(4):331-338.
  530. O'Donnell CJ, Larson MG, Feng D, Sutherland PA, Lindpaintner K, Myers RH, D'Agostino RA, Levy D, Tofler GH. Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation. 2001 Jun 26; 103(25):3051-6. PMID: 11425767.
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  531. Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O'Donnell CJ, Wilson PW. Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int. 2001 May; 68(5):271-6. PMID: 11683533.
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  532. Lloyd-Jones DM, O'Donnell CJ, Silbershatz H, D'Agostino RB, Wilson PWF. Applicability of Cholesterol-Lowering Primary Prevention Studies to a General Population: The Framingham Heart Study. Archives in Internal Medicine. 2001; 161(7):949-954.
  533. Lloyd-Jones DM, O'Donnell CJ, D'Agostino RB, Massaro J, Silbershatz H, Wilson PW. Applicability of cholesterol-lowering primary prevention trials to a general population: the framingham heart study. Arch Intern Med. 2001 Apr 09; 161(7):949-54. PMID: 11295957.
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  534. Wilson PW, Kauppila LI, O'Donnell CJ, Kiel DP, Hannan M, Polak JM, Cupples LA. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation. 2001 Mar 20; 103(11):1529-34. PMID: 11257080.
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  535. Meigs JB, Larson MG, D'Agostino RB, Levy D, Clouse ME, Natan DM, Wilson PWF, O'Donnell CJ. Coronary Artery Calcification in Type 2 Diabetes and Insulin Resistance: ?The Framingham Offspring Study. Circulation. 2001; 103(9):1344.
  536. O'Donnell CJ, Benjamin EJ, Corey D, Newton-Cheh CH, Levy D, D'Agostino RB, Larson MG. The PR Interval is a Heritable Quantitative Trait with Evidence for Linkage to Chromosome 4 in a Genome-wide Scan: The Framingham Heart Study. Circulation. 2001; 103(9):1354.
  537. O'Donnell CJ, Larson MG, Kupka M, Manning WJ, Levy D, Clouse ME. Cumulative Effects of Cholesterol and Other Risk Factors on Coronary Artery Calcification in Men and Women: The Framingham Heart Study. Circulation. 2001; 103(9):1368.
  538. Walsh CR, Larson MG, Kupka MJ, Manning WJ, Clouse ME, O'Donnell CJ. Prevalence of Aortic Valve Calcium Detected by Electron Beam Computed Tomography and Association with Calcium Deposits in the Coronary Arteries and Aorta. Circulation. 2001; 104(17):II-537.
  539. Yang Q, Tofler GH, Cupples LA, Larson MG, Levy D, D'Agostino RB, O'Donnell CJ. A Genome-wide Scan for Circulating Levels of Fibrinogen in the Framingham Heart Study. American Journal of Human Genetics. 2001; 69(4).
  540. Chan SK, Jaffer FA, Botnar RM, Kissinger KV, Goepfert L, Chuang ML, O'Donnell CJ, Levy D, Manning WJ. Scan reproducibility of magnetic resonance imaging assessment of aortic atherosclerosis burden. J Cardiovasc Magn Reson. 2001; 3(4):331-8. PMID: 11777225.
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  541. Feng D, Larson MG, Lindpaintner K, O'Donnell CJ, Mittleman M, Lipinska I, D'Agostino RB, Levy D, Tofler GH. Platelet GPIIIa PLA Polymorphism and Incident Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 2001; 37(2):304A.
  542. Hirschhorn JN, Altshuler D, Daly MJ, Lindgren CM, Burtt NP, Loomer M, Villapakkam A, Bolk S, O'Donnell CJ, Crews JD, Groop LC, Lander ES. Linkage Disequilibrium at PPARG and Other Genes Assessed with Dense Sets of SNPs. American Journal of Human Genetics. 2001; 69(4).
  543. O'Donnell CJ, Larson MG, Kupka MJ, Jaffer FA, Clouse ME, Levy D, Manning WJ. Subclinical Aortic Atherosclerosis Detected by MRI is Associated with Aortic and Coronary Calcificaiton and Carotid Intimal Medial LThickness in the Framingam Heart Study. Circulation. 2001; 104(17):II-375.
  544. Chuang ML, Salton CJ, Kissinger KV, Levy D, O'Donnell CJ, Manning WJ. M-Mode Errors in Determination of Left Ventricular Mass are Greater with Increasing Cavity Size and Wall thickness: an MRI Study. Journal of the American College of Cardiology. 2001; 837(2):392A.
  545. Morshedi-Meibodi A, Larson MG, Levy D, O'Donnell CJ, Vasan RS. Heart Rate Recovery after Exercise Testing and Risk of Coronary Disease in the Framingham Heart Study. Journal of the American College of Cardiology. 2001; 37(2):184A.
  546. Balady GJ, Larson MG, Vasan RS, O'Donnell CJ, Levy D. Does Treadmill Exercise Testing Predict Coronary Disease Risk in Asymptomatic Persons after Accounting for Framingham Risk Score?. Circulation. 2001; 104(17):II-376.
  547. Jeerakathil TJ, Wolf PA, Beiser A, Seshadri S, Case CS, O'Donnell CJ, Massaro JM, D'Agostino RB, DeCarli C. Framingham Coronary Risk Scores Predicts White Matter Hykperintensity and Total Cerebral Brain Volume: The Framingham Offspring Study. Neurology. 2001; 56((8) Supplement 3 ):A107-A108.
  548. O'Donnell CJ, Kiel DP, Hannan M, Wilson PWF. Do subclinical Arterial Calcific Deposits Predict Coronary Heart Disease Risk Beyond Risk Factor Profiles?. Circulation. 2001; 104(7):II-794.
  549. Chuang ML, Salton CJ, Kissinger KV, Levy D, O'Donnell CJ, Mannibng WJ. Relation Between Left Ventricular Sphericity and Errors in M-Mode Mass: Insights from Magnetic Resonance Imaging. Journal of the American College of Cardiology. 2001; 37(2):388A.
  550. Vasan RS, Larson MG, Levy D, Corey D, O'Donnell CJ, Benjamin EJ. Heritability and Genetic Linkage for Aortic Root and Left Atrial Size: The Framingham Heart Study. Circulation. 2001; 104(17):II-829.
  551. Jeerakathil TJ, Wolf PA, Beiser A, Seshadri S, Case CS, O'Donnell CJ, Massaro JM, D'Agostine RB, DeCarli C. Framingham Coronary Risk Scores Predicts White Matter Hyperintensity and Total Cerebral Brain Volume: The Framingham Offspring Study. Neurology. 2001; 56((8) Supplement 3):A107-A108.
  552. O'Donnell CJ, Larson MG, Kupka M, Manninbg WJ, Levy D, Clouse ME. Cumulative Effects of Cholesterol and Other Risk Factors on Coronary Artery Calcification in Men and Women: The Framingham Heart Center. Circulation. 2001; 103(9):1368.
  553. Walsh CR, Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Clinical trials of unfractionated heparin and low-molecular-weight heparin in addition to aspirin for the treatment of unstable angina pectoris: do the results apply to all patients? Am J Cardiol. 2000 Nov 01; 86(9):908-12. PMID: 11053697.
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  554. Walsh CR, Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Clinical Trials of Unfractionated Heparin and Low-Molecular Weight Heparin in Addition to Aspirin for the Treatment of Unstable Angina Pectoris: Do the Results Apply to all Patients?. American Journal of Cardiology. 2000; 86(9):908-912.
  555. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Roccella EJ, Levy D. Differential control of systolic and diastolic blood pressure : factors associated with lack of blood pressure control in the community. Hypertension. 2000 Oct; 36(4):594-9. PMID: 11040241.
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  556. Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension. 2000 Oct; 36(4):477-83. PMID: 11040222.
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  557. Singh JP, Larson MG, O'Donnell CJ, Wilson PF, Tsuji H, Lloyd-Jones DM, Levy D. Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol. 2000 Aug 01; 86(3):309-12. PMID: 10922439.
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  558. O'Donnell CJ, Levy D. Weighing the evidence for infection as a risk factor for coronary heart disease. Curr Cardiol Rep. 2000 Jul; 2(4):280-7. PMID: 10953260.
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  559. Giugliano RP, Lloyd-Jones DM, Camargo CA, Makary MA, O'Donnell CJ. Association of unstable angina guideline care with improved survival. Arch Intern Med. 2000 Jun 26; 160(12):1775-80. PMID: 10871970.
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  560. Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Effect of leukocytosis at initial examination on prognosis in patients with primary unstable angina. Am Heart J. 2000 May; 139(5):867-73. PMID: 10783221.
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  561. Feng D, Tofler GH, Larson MG, O'Donnell CJ, Lipinska I, Schmitz C, Sutherland PA, Johnstone MT, Muller JE, D'Agostino RB, Levy D, Lindpaintner K. Factor VII gene polymorphism, factor VII levels, and prevalent cardiovascular disease: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2000 Feb; 20(2):593-600. PMID: 10669660.
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  562. DeStefano AL, Benjamin EJ, Larson MG, O'Donnell CJ, Vasan RS, Cupples LA, Myers RH, Levy D. Transformation of Left Ventricular(LV) Phenotypes in a Genome Scan in the NHLBI's Framingham Heart Study (FHS). Genome Epidemiology. 2000; 19:245.
  563. Larson MG, O'Donnell CJ, Cupples LA, Feng D, Caunt D, D'Agostine RB, Myers RH, Tofler GH. Evidence for a Gene on Chromosome 10 Influencing Factor VII Levels: A Genome-wide Scan in the Framingham Heart Study. Circulation. 2000; 102:II-259.
  564. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, D'Agostino RB, Levy D, Tofler GH. . The Fibrinogen Beta Hind III-148 Polymorphism and Prevalent Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 2000; 35(2):258A.
  565. Newton-Cheh CH, Larson MG, Benjamin EJ, Caunt D, D'Agostino RB, O'Donnell CJ. The QT Interval is a Heritable Quantitative Trait with Evidence for Linkage to Chromosome 3 in a Genome-wide Scan: The Framingham Heart Study. Circulation. 2000; 102:II-584.
  566. Kiel DP, Hannan MT, Cupples LA, Wilson PWF, Levy D, Clouse ME, Krueger-Lovy K, O'Donnell CJ. Low Bone Mineral Density is Associated with Coronary Artery Calcification. Journal of Bone Mineral Research. 2000; 15(Supplemental I):S160.
  567. DeStefano AL, Benjamin EJ, Larson MG, O'Donnell CJ, Vasan RS, Cupples LA, Myers RH, Levy D. Transformation of Left Ventricular (LV) Phenotypes in a Genome Scan in the NHLBI's Framingham Heart Study (FHS). Genome Epidemiology. 2000; 19:245.
  568. O'Donnell CJ, Larson MG, Cupples LA, Feng D, Caunt D, D'Agostino RB, Myers RH, Tofler GH. A Genome-wide Scan for Circulating Levels of Plasminogen Activator Inhibitor-1 and Tissue Plasminogen Activator in the Framingham Heart Study. Circulation. 2000; 102:II-257.
  569. O'Donnell CJ. Cardiovascular Genomics; Recent Progress, Current Challenges, Future Promise. Genome Biology. 2000; 1(Reports 409):1-409.3.
  570. Benjamin EJ, DeStefano AL, Larson MG, O'Donnell CJ, Vasan RS, Levy D. Genetic Linkage Analyses for Left Ventricular Mass Phenotypes in the Framingham Heart Study. Circulation. 2000; 102:II-860.
  571. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Caunt D, Levy D. Genome Scan Linkage Results for Heart Rate Variability: The Framingham Heart Study. Circulation. 2000; 102:II-684.
  572. Vasan RS, Larson MG, Evans JC, O'Donnell CJ, Levy D. High Normal Blood Pressure and Risk of Cardiovascular Disease: The Framingham Heart Study. Circulation. 2000; 101(6):715.
  573. Kinlay S, Burgess B, Rizoo R, Cordella N, Cabral V, O'Donnell C, Plutzky J. Conventional Coronary Risk Factors are more Frequent in Coronary Artery Bypass Recipients with Premature Atherosclerosis. Journal of the American College of Cardiology. 2000; 35(2):300A.
  574. O'Donnell CJ, Larson MG, Jaffer FA, Kissinger KV, Levy D, Manning WJ. Aortic Atherosclerosis Detected by MRI is Associated with Contemporaneous and Longitudinal Risk Factors: The Framingham Heart Study. Circulation. 2000; 102:II-836.
  575. Lloyd-Jones DM, Camargo CA, Giugliano RP, Walsh CR, Lager RA, O'Donnell CJ. Characteristics and Prognosis of Patients with Suspected Acute Myocardial Infarction and Elevated MB Relative Index but Noarmal Total Creatine Kinase. American Journal of Cardiology. 1999; 84(9):957-962.
  576. Lloyd-Jones DM, Camargo CA, Giugliano RP, Walsh CR, O'Donnell CJ. Characteristics and prognosis of patients with suspected acute myocardial infarction and elevated MB relative index but normal total creatine kinase. Am J Cardiol. 1999 Nov 01; 84(9):957-62. PMID: 10569646.
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  577. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Wilson PW, Levy D. Cross-classification of JNC VI blood pressure stages and risk groups in the Framingham Heart Study. Arch Intern Med. 1999 Oct 11; 159(18):2206-12. PMID: 10527298.
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  578. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Levy D. Differential impact of systolic and diastolic blood pressure level on JNC-VI staging. Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 1999 Sep; 34(3):381-5. PMID: 10489380.
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  579. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Levy D. Differential Impact of Systolic and Diastolic Blood Pressure Level on JNC-VI Staging. Hypertension. 1999; 34(3):381-385.
  580. O'Donnell CJ, Glynn RJ, Field TS, Averback R, Satterfield S, Friesenger GC, Taylor JO, Hennekens CH. Misclassification and under-reporting of acute myocardial infarction by elderly persons: implications for community-based observational studies and clinical trials. J Clin Epidemiol. 1999 Aug; 52(8):745-51. PMID: 10465319.
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  581. O'Donnell CJ, Glynn RJ, Field TS, Averback R, Satterfield S, Friesenger GC, Taylor JO, Hennekens CH. Misclassification and Under-reporting of Recent Hospitalization for Acute Myocardial Infarction by Elderly Persons. Journal of Clinical Epidemiology. 1999; 52(8):745-752.
  582. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Evans JC, Levy D. Heritability of heart rate variability: the Framingham Heart Study. Circulation. 1999 May 04; 99(17):2251-4. PMID: 10226089.
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  583. Singh JP, Larson MG, Manolio TA, O'Donnell CJ, Lauer M, Evans JC, Levy D. Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham heart study. Circulation. 1999 Apr 13; 99(14):1831-6. PMID: 10199879.
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  584. Feng D, Lindpaintner K, Larson MG, Rao VS, O'Donnell CJ, Lipinska I, Schmitz C, Sutherland PA, Silbershatz H, D'Agostino RB, Muller JE, Myers RH, Levy D, Tofler GH. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: the Framingham Offspring Study. Arterioscler Thromb Vasc Biol. 1999 Apr; 19(4):1142-7. PMID: 10195947.
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  585. Feng DL, Lindpaintner K, Larson MG, Rao VS, O'Donnell CJ, Sutherland PA, Silbershatz H, D'Agostino RB, Muller JE, Myers RH, Levy D, Tofler GH. Increased Platelet Aggregability Associated with Platelet GPIIIa PIA2 Polymorphism: The Framingham Offspring Study. Arteriosclerosis Thrombosis Vascular Biology. 1999; 19(4):1142-1147.
  586. Haider AW, Larson MG, O'Donnell CJ, Evans JC, Wilson PW, Levy D. The association of chronic cough with the risk of myocardial infarction: the Framingham Heart Study. Am J Med. 1999 Mar; 106(3):279-84. PMID: 10190375.
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  587. Haider AW, Larson MG, O'Donnell CJ, Evans JC, Wilson PWFW, Levy D. The Association of Chronic Cough with Risk for Myocardial Infarction: The Framingham Heart Study. American Journal of Medicine. 1999; 106(3):279-284.
  588. Feng DL, Tofler G, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, Levy D, Lindpaintner K. The Plasminogen Activator Inhibitor-1 Gene 4G/5G Polymorphism and Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 1999; 33(2):288A.
  589. Almond CS, Camargo CA, Lloyd-Jones DM, Giugliano RP, O'Donnell CJ. Determinants of Inaccurate ECD-9 Coding Among Patients with Unstable Angina. Academy of Emergency Medicine. 1999; 6:403.
  590. O'Donnell CJ, Kannell WB. Myocardial Infarction. In 50 Years of Discovery: Medical Milestones from the National Heart, Lung, and Blood Institute's Framingham Heart Study. Center for Bio-Medical Communication, Inc. 1999; 338-39.
  591. O'Donnell CJ, Cupples LA, Kiel D, Wilson PWF. Is Aortic Atherosclerosis Heritable? Familial Aggregation of Lumbar Aortic Calcification in the Framingham Heart Study. Journal of the American College of Cardiology. 1999; 6:403.
  592. Feng DL, Larson MG, Lindpaintner K, O'Donnell CJ, Lipinska I, Sutherland PA, Levy D, Tofler GH. Platelet GPIIIa Receptor PLa Polymorphism and Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 1999; 33(2):262A.
  593. Feng DL, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, D'Agostino RB, Tofler GH. Platelet GPIIIa P1A2 Polymorphism, Fibrinogen Levels and Platelet Aggregability: The Framingham Heart Study. Circulation. 1999; 100(18):I-327.
  594. Hahn S, Jang IK, O'Donnell CJ. Antithrombotic Therapy for Acute Coronary Syndromes. Part II STE-MI. Journal of Critical Illness. 1999; 14:42-50.
  595. Wilson PWF, O'Donnell CJ, Kiel DP, Hannan M, Cupples LA. Lumbar Aortic Calcification is an Important Predictor of Vascular Morbidity and Mortality. Circulation. 1999; 99:1107.
  596. Lloyd-Jones DM, Evans JC, O'Donnell CJ, Roccella EJ, Levy D. Rates of Hypertension Control Based on Systolic Versus Diastolic Blood Pressure Level. Circulation. 1999; 100(18):I-35.
  597. Feng DL, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, Levy D, Tofler GH. Interaction of beta fibrinogen gene polymorphism with diabetes mellitus: The Framingham Offspring Study. Journal of the American College of Cardiology. 1999; 33(2):312A.
  598. Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Effect of Leukocytosis at Presentation on Prognosis in Unstable Angina. Academy of Emergency Medicine. 1999; 6:419.
  599. Jaffer FA, O'Donnell CJ, Chan SK, Kissinger KV, Levy D, Manning WJ. A New MRI Index of Aortic Atherosclerotic Burden in a Healthy Population. Circulation. 1999; 100(18):I-35.
  600. O'Donnell CJ, Silbershatz H, D'Agostino RA, Haider ?AW, Polak JF, Levy D, Wilson PWF. Relationship of C-Reactive Protein to Carotid Stenosis and Intimal Medial Thickness in the Framingham Heart Study. Circulation. 1999; 100(18):I-477.
  601. Myers RH, O'Donnell CJ. Genetics. In 50 Years of Discovery: Medical Milestones from the National Heart, Lung, and Blood Institute's Framingham Heart Study. Center for Bio-Medical Communication, Inc. 1999; 549-50.
  602. Haider AW, Wilson PWF, Larson MG, Sutherland P, Evans JC, O'Donnell CJ, Wolf PA, Michelson EL, Levy D. Chlamydia, H. Pyloria and Cytomegalovirus seropositivity and risk of cardiovascular disease: The Framingham Heart Study. Journal of the American College of Cardiology. 1999; 33(2):314A.
  603. Walsh CR, Camargo CA, Lloyd-Jones DM, Giugliano RP, O'Donnell CJ. Generalizability of Randomized Controlled Trials of Heparin and Aspirin to Consecutive Patients with Unstable Angina. Academy of Emergency Medicine. 1999; 6(`):424.
  604. Haider AW, WilsonPWF, Larson MG, O'Donnell CJ, Wolf PA, D'Agostine RA, Michelson EL, Levy D. Association of H Pylori, C Pneumoniae and Cytomegalovirus Seropositivity with Cardiovascular Disease in the Framingham Heart Study. Circulation. 1999; 100(18):I-521.
  605. Feng DL, Lindpaintner K, Larson MG, O'Donnell CJ (presenter), Lipinska I, Sutherland PA, Levy D, Tofler GH. The Contribution of Genetic (4G/5G polymorphism) and Environmental Factors to Plasminogen Activator Inhibitor-1 Antigen Levels: The Framingham Offspring Study. Journal of the American College of Cardiology. 1999; 33(2):312A.
  606. O'Donnell CJ, Kannel WB. Is there a racial predisposition to hypertension? Hypertension. 1998 Nov; 32(5):817-9. PMID: 9822437.
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  607. O'Donnell CJ, Kannel WB. Cardiovascular risks of hypertension: Lessons from Observational Studies. Journal of Hypertension. 1998; 16((Suppl)):S3-S7.
  608. O'Donnell CJ, Kannel WB. Cardiovascular risks of hypertension: lessons from observational studies. J Hypertens Suppl. 1998 Oct; 16(6):S3-7. PMID: 9856377.
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  609. Singh JP, Larson MG, Tsuji H, Evans JC, O'Donnell CJ, Levy D. Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension. 1998 Aug; 32(2):293-7. PMID: 9719057.
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  610. Himmelmann A, Hedner T, Hansson L, O'Donnell CJ, Levy D. Isolated systolic hypertension: an important cardiovascular risk factor. Blood Press. 1998 Jul; 7(4):197-207. PMID: 9858111.
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  611. Giugliano RP, Camargo CA, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Eagle KA, Fuster V, O'Donnell CJ. Elderly patients receive less aggressive medical and invasive management of unstable angina: potential impact of practice guidelines. Arch Intern Med. 1998 May 25; 158(10):1113-20. PMID: 9605783.
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  612. Lloyd-Jones DM, Camargo CA, Lapuerta P, Giugliano RP, O'Donnell CJ. Electrocardiographic and Clinical Predictors of Myocardial Infarction in Patients Presenting with Unstable Angina. American Journal of Cardiology. 1998; 81(10):1182-1186.
  613. Lloyd-Jones DM, Camargo CA, Lapuerta P, Giugliano RP, O'Donnell CJ. Electrocardiographic and clinical predictors of acute myocardial infarction in patients with unstable angina pectoris. Am J Cardiol. 1998 May 15; 81(10):1182-6. PMID: 9604942.
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  614. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, Myers RH, Levy D. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation. 1998 May 12; 97(18):1766-72. PMID: 9603529.
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  615. Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, Ruskin JN, Manson JE. Fish consumption and risk of sudden cardiac death. JAMA. 1998 Jan 07; 279(1):23-8. PMID: 9424039.
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  616. Singh J, Larson MG, O'Donnell CJ, Tsuji H, Levy D. Heritability of Heart Rate Variability: The Framingham Heart Study. Journal of the American College of Cardiology. 1998; 31(2):169A.
  617. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lilbershatz H, Lipinska I, Sutherland P, Muller JE, D'Agostino RB, Myers RH, Tofler GH. Factor VII Gene Polymorphism and Cardiovascular Disease: The Framingham Heart Study. Circulation. 1998; 98(17):I-458.
  618. Camargo CA, Lloyd-Jones DM, Giugliano RP, O'Donnell CJ. Characteristics and Prognosis of Patients with Acute Myocardial Infarction who Present with Atypical Symptoms. Annals of Emergency Medicine. 1998; 32:S2.
  619. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Levy D. Systolic Versus Diastolic Blood Pressure Level as the Criterion for JNC-VI Blood Pressure Stage Classification: The Framingham Heart Study. Circulation. 1998; 98(17):I-518.
  620. O'Donnell CJ, Cupples LA, Kauppila LI, Kiel DP, Hannan MT, Polak JF, Wilson PWF. Heritability of Platelet Aggregation in the Framingham Heart Study. Circulation. 1998; 97:830.
  621. dLloyd Jones DM, O'Donnell CJ, Silbershatz H, D'Agostino, Jr. RB, Wilson PWF. Applicability of Cholesterol-Lowering Primary Prevention Studies to a General Population. Circulation. 1998; 98(17):I-46.
  622. Liel-Cohen N, Hunziker PR, O'Donnell CJ. Transthoracic Echocardiography Identifies Stroke Patients Free of Significant Thoracic Aortic Atherosclerosis. Circulation. 1998; 98(17):I-100.
  623. O'donnell CJ, Cupples LA, Kauppila LI, Kiel DP, Hannan MT, Polak JF, Wilson PWF. Risk Factors Associated with Progression of Lumbar Aortic Calcification. Circulation. 1998; 97.
  624. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Schimitz C, Sutherland PA, Johnstone MT, Muller JE, Levy D, Tofler GH. Genetic and Environmental Influences on Factor VII Levels: The Framingham Heart Study. Circulation. 1998; 97:830.
  625. Giugliano RP, Camargo CA, Makary MA, Lloyd-Jones DM, O'Donnell CJ. Unstable Angina Guideline is Associated with Improved Outcome. Journal of the American College of Cardiology. 1998; 31(2):208A.
  626. Hahn S, Jang IK, O'Donnell CJ. Antithrombotic Therapy for Acute Coronary Syndromes, Part I: STE-MI. Journal of Critical Illness. 1998; 13:772-81.
  627. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Lloyd-Jones DM, Wilson P, Levy D. Hyperglycemia is Associated with Reduced Heart Rate Variability. Circulation. 1998; 98(17):I-647.
  628. Haider AW, Roubenoff R, Silbershatz H, D'Agostino R, Levy D, O'Donnell CJ. Inflamation, Cytokine Production and Atherosclerotic Cardiovascular Disease in the Elderly: The Framingham Heart Study. Circulation. 1998; 98(17):I-207.
  629. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation. 1997 Oct 21; 96(8):2520-5. PMID: 9355888.
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  630. O'Donnell CJ, Ridker PM, Glynn RJ, Berger K, Ajani U, Manson JE, Hennekens CH. Hypertension and Borderline Isolated Systolic Blood Pressure Increase Risks of Cardiovascular Disease and Mortality in Male Physicians. Circulation. 1997; 95(5):1132-1137.
  631. O'Donnell CJ, Ridker PM, Glynn RJ, Berger K, Ajani U, Manson JE, Hennekens CH. Hypertension and borderline isolated systolic hypertension increase risks of cardiovascular disease and mortality in male physicians. Circulation. 1997 Mar 04; 95(5):1132-7. PMID: 9054841.
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  632. O'donnell CJ, Larson MG, Feng DL, Lindpaintner K, Myers RH, Levy D, Tofler G. Heritability Assessment of Hemostatic Factors in the Framingham Heart Study. Circulation. 1997; 96(8):I-412.
  633. O'Donnell CJ, Cupples LA, Kauppila LI, Polak JF, Levy D, Wilson PWF. Association of Subclinical Lumbar Aortic Calcification with Coronary Heart Disease Risk Factors. Canadian Journal of Cardiology. 1997; 13((Suppl B)):182B.
  634. Feng D, Tofler GH, Larson MG, O'Donnell CJ, Lipinska I, Schimitz C, Sutherland P, Muller JE, Levy D, Lindpaintner K. Genetic Determination of Factor VII Levels: The Framingham Offspring Study. Circulation. 1997; 96(8):I-2.
  635. Haider AW, Evans JC, Larson MG, O'Donnell CJ, Levy D. Chronic Bronchitis and Risk of Myocardial Infarction: The Framingham Heart Study. Circulation. 1997; 96(8):I-291.
  636. Singh JP, Larson MG, Tsuji H, Evans JC, O'Donnell CJ, Levy D. . Reduced Heart Rate Variability: A Risk Factor for New Onset Hypertension. Circulation. 1997; 96(8):I-406.
  637. Lloyd-Jones DM, Camargo CA, Giugliano RP, Walsh CR, Lager RA, O'Donnell CJ. Clinical Characteristics and Prognosis of Patients with Normal Creatine Kinase but Elevated MB Isoenzyme Fraction. Circulation. 1997; 96(8):I-406.
  638. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Schimitz C, Sutherland P, Muller JE, Levy D, Tofler GH. Increased Platelet Aggregability Associated with Platelet GPIIIa PLA2 Polymorphism. Circulation. 1997; 96(8):I-333.
  639. O'Donnell CJ, Lindpaintner K, Larson MG, Ordovas JM, Myers RH, Levy D. The ACE Deletion-Insertion Polymorphism and Hypertension: An Association Analysis in the Framingham Heart Study. Journal of the American College of Cardiology. 1997; 29(2):84A.
  640. Singh JP, Larson MG, Manolio TA, Lauer MS, Evans JC, O'Donnell CJ, Levy D. Blood Pressure Response During Treadmill Exercise Testing as a Risk Factor for the Development of Hypertension. Circulation. 1997; 96(8):I-223.
  641. Giuliano RP, Camargo CA, Lloyd-Jones DM, Pasternak RC, O'Donnell CJ. Differences in Lipid Management Across the Spectrum of Acute Coronary Disease. Journal of the American College of Cardiology. 1997; 29(2):400A.
  642. Paul SD, O'Gara PT, Mahjoub ZA, DiSalvo TG, O'Donnell CJ, Newell JB, Villarreal-Levy G, Smith AJ, Kondo NI, Cararach M, Ferrer L, Eagle KA. Geriatric patients with acute myocardial infarction: Cardiac risk factor profiles, presentation, thrombolysis, coronary interventions, and prognosis. Am Heart J. 1996 Apr; 131(4):710-5. PMID: 8721643.
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  643. O'Donnell CJ, Sleight P, Manson JE. Coronary Health Promotion. In Prevention of Myocardial Infarction. 1996.
  644. O'Donnell CJ, Manson JE. (Lipid-Lowering Agents) and (Oral Antihypertensive Agents). In Prevention of Myocardial Infarction. 1996.
  645. Camargo CA, Giugliano RP, Lloyd-Jones DM, Suratt B, Fuster V, O'donnell CJ. Are Guideline Recommendations Based on Randomized Trial Results Already Followed by Practicing Physicians?. Academic Emergency Medicine. 1996; 3:394.
  646. Albert CM, Manson JE, O'Donnell CJ, Ajani UA, Hennekens CH. Fish Consumption and the Risk of Sudden Death in the Physicians' Health Study. Circulation. 1996; 94(8):I-578.
  647. Giugliano RP, Camargo CA, Lloyd-Jones DM, Pasternak RC, O'Donnell CJ. Prevalence of Hypercholesterolemia and Lipid Management in Patients Presenting with Unstable Angina. Journal of the American College of Cardiology. 1996; 27(2):134A.
  648. Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Electrocardiographic Predictors of Myocardial Infarction in Patients Presenting with Unstable Angina. Journal of the American College of Cardiology. 1996; 27(2):181A.
  649. O'Donnell CJ, Gillman MW, Gaziano MJ, Ajani U, Glynn RJ, Manson JE, Hennekens CH. Low to Moderate Levels of Alcohol Intake and Incidence of Hypertension. American Journal Epidemiology. 1996; 143(11):S50.
  650. O'Donnell CJ, Jonas MA, Hennekens CH. Aspirin augmentation of the efficacy of thrombolysis. Coron Artery Dis. 1995 Dec; 6(12):936-9. PMID: 8723015.
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  651. Paul SD, Eagle KA, Guidry U, DiSalvo TG, Villarreal-Levy G, Smith AJ, O'Donnell CJ, Mahjoub ZA, Muluk V, Newell JB, et al. Do gender-based differences in presentation and management influence predictors of hospitalization costs and length of stay after an acute myocardial infarction? Am J Cardiol. 1995 Dec 01; 76(16):1122-5. PMID: 7484895.
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  652. Hennekens CH, O'Donnell CJ, Ridker PM. Current and future perspectives on antithrombotic therapy of acute myocardial infarction. Eur Heart J. 1995 Jul; 16 Suppl D:2-9. PMID: 8542867.
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  653. Hennekens CH, O'Donnell CJ, Ridker PM, Marder V. Thrombolytic Therapy in Acute Myocardial Infarction. Journal of the American College of Cardiology. 1995; 25((Suppl)):18S-22S.
  654. Hennekens CH, O'Donnell CJ, Ridker PM, Marder VJ. Current issues concerning thrombolytic therapy for acute myocardial infarction. J Am Coll Cardiol. 1995 Jun; 25(7 Suppl):18S-22S. PMID: 7775709.
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  655. O'Donnell CJ, Ridker PM, Hebert PR, Hennekens CH. Antithrombotic therapy for acute myocardial infarction. J Am Coll Cardiol. 1995 Jun; 25(7 Suppl):23S-29S. PMID: 7775710.
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  656. O'Donnell CJ, Ridker PM, Hebert P, Hennekens CH. Antithrombotic Therapy in Acute Myocardial Infarction. Journal of the American College of Cardiolgy. 1995; 25((7 Suppl)):23S-29S.
  657. O'Donnell CJ, Ridker PM, Hennekens CH. Thrombolytic therapy for acute myocardial infarction. Applying lessons from randomized trials to community practice. Ann Epidemiol. 1995 May; 5(3):250-2. PMID: 7606316.
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  658. O'Donnell Cj, Ridker PM, Berger K, LaMotte F, Glynn RJ, Manson JE, Hennekens CH. Borderline Isolated Systolic Hypertension and Subsequent Risk of Cardiovascular Disease. Journal of the American College of Cardiology. 1995; 25:24A.
  659. Ridker PM, O'Donnell CJ, Hennekens CH. Direct Comparison of Aspirin plus Hirudin, Aspirin plus Heparin, and Aspirin Alone Among 12,000 Patients with Acute Myocardial Infarction not Receiving Thrombolysis: Rational and Design of the First American Study of Infarct Survival (ASIS-1). Journal of Thrombosis and Thrombolysis. 1995; 1(2):119-124.
  660. Camargo CA, Giugliano RP, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, O'Donnell CJ. Circadian Variation in Unstable Angina and Non-ST Elevationb Myocardial Infarction: Effect of Cardiac Risk Factors and Medications. Circulation. 1995; 92(8):I-776.
  661. Giugliano RP, Camargom CA, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Fuster V, O'Donnell CJ. Would Guidelines Change Care of Elderly Patients with Unstable Angina?. Circulation. 1995; 92(8):I-19.
  662. O'Donnell CJ, Eagle KA, O'Gara PT, Paul SD. Eligibility for Thrombolytic Therapy is Limited Even with Expanded Criteria. Journal of the American College of Cardiology. 1995; 25:206A.
  663. Silver MT, Rose GA, Paul SD, O'Donnell CJ, O'Gara PT, Eagle KA. A clinical rule to predict preserved left ventricular ejection fraction in patients after myocardial infarction. Ann Intern Med. 1994 Nov 15; 121(10):750-6. PMID: 7944052.
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  664. Ridker PM, O'Donnell CJ, Marder VJ, Hennekens CH. A Response to "Holding GUSTO up to theLight". Annals of Internal Medicine. 1994; 120(11):970.
  665. Berger K, Kase C, LaMotte F, O'Donnell CJ, Glynn RJ, Hennekens CH. Alcohol Consumption, Blood Pressure and Ischemic Stroke Among US Physicians. Circulation. 1994; 90(4):I-399.
  666. Villareal-Levy G, Smith AJC, Muluk VS, O'Donnell CJ, Newell J, Eagle KA, O'Gara PT. . Gender Differences in the Evaluation and Treatment of Patients with Myocardial Infarction. Circulation. 1994; 90(4):I-44.
  667. Silver MT, Rose GA, Paul SD, O'Donnell CJ, O'Gara PT, Eagle KA. Predicting Preserved Left Ventricular Ejection Fraction in Patients After Myocardial Infarction: Derivation and Validation of a Simple Clinical rule. Circulation. 1994; 90(4):I-44.
  668. Ridker PM, O'Donnell C, Marder VJ, Hennekens CH. Large-scale trials of thrombolytic therapy for acute myocardial infarction: GISSI-2, ISIS-3, and GUSTO-1. Ann Intern Med. 1993 Sep 15; 119(6):530-2. PMID: 8357123.
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  669. O'Donnell CJ, Eagle KA. Preventive Cardiology in Women: The Evolving Role of Postmenopausal Estrogen Replacement in the Prevention of Cardiovascular Disease. The Female Patient. 1992.
  670. Coles NA, O'Donnell CJ(presenter), Muluk V, Fields T, Zisfein J, Barsky A, Hochstrasser B, Lipson R, Cothern M, Boucher C, Eagle K. Comparative Usefulness of Pre-Discharge Holter and Thallium for Post-MI Risk Stratification. Circulation. 1992; 86(4):I-139.
  671. Barsky AJ, Hochstrasser B, Coles A, Zisfein J, O'Donnell CJ, Eagle KA. Silent Myocardial Ischemia: Is the Person or the Event Silent?. Journal of the American Medical Association. 1990; 264(9):1132-1135.
  672. Lavender JP, Stuttle AW, Peters AM, O'Donnell CJ, Davies GJ, Harrison R, Hogg N. In vivo studies with an anti-platelet monoclonal antibody; P256. Nucl Med Commun. 1988 Oct; 9(10):817-22. PMID: 3211440.
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  673. Fain JN, Garcia-Sainz JA, Mills I, O'Donnell CJ. Activation of lipolysis and cyclic AMP accumulation in rabbit adipocytes by isoproterenol in the presence of forskolin or pertussis toxin. Biochim Biophys Acta. 1984 Apr 24; 798(3):382-9. PMID: 6324881.
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  674. Fain JN, O'Donnell CJ, Mills I, Gárciá-Sáinz JA. Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase. Biochem Biophys Res Commun. 1983 Oct 31; 116(2):651-6. PMID: 6686037.
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