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Michael Joseph Young, Ph.D.


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  1. R01EY009595 (YOUNG, MICHAEL JOSEPH) May 1, 1992 - Jun 30, 2005
    Immune Privilege and Retinal Transplantation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kundu J, Michaelson A, Talbot K, Baranov P, Young MJ, Young MJ, Carrier RL. Decellularized retinal matrix: Natural platforms for human retinal progenitor cell culture. Acta Biomater. 2016 Feb; 31:61-70. PMID: 26621699.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  2. Yao J, Ko CW, Baranov PY, Regatieri CV, Redenti S, Tucker BA, Mighty J, Tao SL, Young MJ. Enhanced differentiation and delivery of mouse retinal progenitor cells using a micropatterned biodegradable thin-film polycaprolactone scaffold. Tissue Eng Part A. 2015 Apr; 21(7-8):1247-60. PMID: 25517296.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  3. Huang R, Baranov P, Lai K, Zhang X, Ge J, Young MJ. Functional and morphological analysis of the subretinal injection of human retinal progenitor cells under Cyclosporin A treatment. Mol Vis. 2014; 20:1271-80. PMID: 25352736.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  4. Baranov PY, Tucker BA, Young MJ. Low-oxygen culture conditions extend the multipotent properties of human retinal progenitor cells. Tissue Eng Part A. 2014 May; 20(9-10):1465-75. PMID: 24320879; PMCID: PMC4251088.
    Citations: 26     Fields:    Translation:HumansCells
  5. Liu Y, Wang R, Zarembinski TI, Doty N, Jiang C, Regatieri C, Zhang X, Young MJ. The application of hyaluronic acid hydrogels to retinal progenitor cell transplantation. Tissue Eng Part A. 2013 Jan; 19(1-2):135-42. PMID: 22953745.
    Citations: 19     Fields:    Translation:AnimalsCells
  6. Velez G, Weingarden AR, Tucker BA, Lei H, Kazlauskas A, Young MJ. Retinal Pigment Epithelium and Müller Progenitor Cell Interaction Increase Müller Progenitor Cell Expression of PDGFRa and Ability to Induce Proliferative Vitreoretinopathy in a Rabbit Model. Stem Cells Int. 2012; 2012:106486. PMID: 22966235.
    Citations: 7     
  7. Cai S, Smith ME, Redenti SM, Wnek GE, Young MJ. Mouse retinal progenitor cell dynamics on electrospun poly (?-caprolactone). J Biomater Sci Polym Ed. 2012; 23(11):1451-65. PMID: 21781383.
    Citations: 9     Fields:    Translation:AnimalsCells
  8. Trese M, Regatieri CV, Young MJ. Advances in Retinal Tissue Engineering. Materials (Basel). 2012 Jan 05; 5(1):108-120. PMID: 28817034; PMCID: PMC5448948.
    Citations: 9     
  9. Ma J, Kabiel M, Tucker BA, Ge J, Young MJ. Combining chondroitinase ABC and growth factors promotes the integration of murine retinal progenitor cells transplanted into Rho(-/-) mice. Mol Vis. 2011; 17:1759-70. PMID: 21750603.
    Citations: 21     Fields:    Translation:AnimalsCells
  10. Checa-Casalengua P, Jiang C, Bravo-Osuna I, Tucker BA, Molina-Martínez IT, Young MJ, Herrero-Vanrell R. Retinal ganglion cells survival in a glaucoma model by GDNF/Vit E PLGA microspheres prepared according to a novel microencapsulation procedure. J Control Release. 2011 Nov 30; 156(1):92-100. PMID: 21704662.
    Citations: 29     Fields:    Translation:AnimalsCells
  11. Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One. 2011 Apr 29; 6(4):e18992. PMID: 21559507; PMCID: PMC3084746.
    Citations: 160     Fields:    Translation:AnimalsCells
  12. Yao J, Tucker BA, Zhang X, Checa-Casalengua P, Herrero-Vanrell R, Young MJ. Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells. Biomaterials. 2011 Feb; 32(4):1041-50. PMID: 21030072.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  13. Sodha S, Wall K, Redenti S, Klassen H, Young MJ, Tao SL. Microfabrication of a three-dimensional polycaprolactone thin-film scaffold for retinal progenitor cell encapsulation. J Biomater Sci Polym Ed. 2011; 22(4-6):443-56. PMID: 20566039.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  14. Gu P, Yang J, Wang J, Young MJ, Klassen H. Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation. Mol Vis. 2009 Oct 20; 15:2111-22. PMID: 19862338.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  15. Tucker BA, Redenti SM, Jiang C, Swift JS, Klassen HJ, Smith ME, Wnek GE, Young MJ. The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation. Biomaterials. 2010 Jan; 31(1):9-19. PMID: 19775744.
    Citations: 32     Fields:    Translation:AnimalsCells
  16. Tackenberg MA, Tucker BA, Swift JS, Jiang C, Redenti S, Greenberg KP, Flannery JG, Reichenbach A, Young MJ. Müller cell activation, proliferation and migration following laser injury. Mol Vis. 2009 Sep 17; 15:1886-96. PMID: 19768129.
    Citations: 33     Fields:    Translation:AnimalsCells
  17. Redenti S, Neeley WL, Rompani S, Saigal S, Yang J, Klassen H, Langer R, Young MJ. Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials. 2009 Jul; 30(20):3405-14. PMID: 19361860.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  18. Saint-Geniez M, Maharaj AS, Walshe TE, Tucker BA, Sekiyama E, Kurihara T, Darland DC, Young MJ, D'Amore PA. Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One. 2008; 3(11):e3554. PMID: 18978936.
    Citations: 269     Fields:    Translation:AnimalsCells
  19. Klassen H, Warfvinge K, Schwartz PH, Kiilgaard JF, Shamie N, Jiang C, Samuel M, Scherfig E, Prather RS, Young MJ. Isolation of progenitor cells from GFP-transgenic pigs and transplantation to the retina of allorecipients. Cloning Stem Cells. 2008 Sep; 10(3):391-402. PMID: 18729769.
    Citations: 25     Fields:    Translation:AnimalsCells
  20. Tucker B, Klassen H, Yang L, Chen DF, Young MJ. Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1686-95. PMID: 18385092; PMCID: PMC2613950.
    Citations: 27     Fields:    Translation:AnimalsCells
  21. Neeley WL, Redenti S, Klassen H, Tao S, Desai T, Young MJ, Langer R. A microfabricated scaffold for retinal progenitor cell grafting. Biomaterials. 2008 Feb; 29(4):418-26. PMID: 17961646.
    Citations: 40     Fields:    Translation:AnimalsCells
  22. Klassen H, Schwartz PH, Ziaeian B, Nethercott H, Young MJ, Bragadottir R, Tullis GE, Warfvinge K, Narfstrom K. Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat. Vet Ophthalmol. 2007 Jul-Aug; 10(4):245-53. PMID: 17565557.
    Citations: 18     Fields:    Translation:AnimalsCells
  23. Ng TF, Lavik E, Keino H, Taylor AW, Langer RS, Young MJ. Creating an immune-privileged site using retinal progenitor cells and biodegradable polymers. Stem Cells. 2007 Jun; 25(6):1552-9. PMID: 17548532.
    Citations: 6     Fields:    Translation:AnimalsCells
  24. Zhang Y, Klassen HJ, Tucker BA, Perez MT, Young MJ. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. J Neurosci. 2007 Apr 25; 27(17):4499-506. PMID: 17460063; PMCID: PMC6673008.
    Citations: 40     Fields:    Translation:AnimalsCells
  25. Tao S, Young C, Redenti S, Zhang Y, Klassen H, Desai T, Young MJ. Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab Chip. 2007 Jun; 7(6):695-701. PMID: 17538710.
    Citations: 39     Fields:    Translation:AnimalsCells
  26. Klassen H, Kiilgaard JF, Zahir T, Ziaeian B, Kirov I, Scherfig E, Warfvinge K, Young MJ. Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients. Stem Cells. 2007 May; 25(5):1222-30. PMID: 17218397.
    Citations: 45     Fields:    Translation:AnimalsCells
  27. Ng TF, Klassen HJ, Hori J, Young MJ. Retinal transplantation. Chem Immunol Allergy. 2007; 92:300-316. PMID: 17264505.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Zahir T, Klassen H, Tomita M, Young MJ. Sorbitol causes preferential selection of Muller glial precursors from late retinal progenitor cells in vitro. Mol Vis. 2006 Dec 20; 12:1606-14. PMID: 17200660.
    Citations: 4     Fields:    Translation:AnimalsCells
  29. Tomita M, Mori T, Maruyama K, Zahir T, Ward M, Umezawa A, Young MJ. A comparison of neural differentiation and retinal transplantation with bone marrow-derived cells and retinal progenitor cells. Stem Cells. 2006 Oct; 24(10):2270-8. PMID: 17008430.
    Citations: 29     Fields:    Translation:AnimalsCells
  30. Warfvinge K, Kiilgaard JF, Klassen H, Zamiri P, Scherfig E, Streilein W, Prause JU, Young MJ. Retinal progenitor cell xenografts to the pig retina: immunological reactions. Cell Transplant. 2006; 15(7):603-12. PMID: 17176612.
    Citations: 17     Fields:    Translation:AnimalsCells
  31. Young MJ, Borrás T, Walter M, Ritch R. Tissue bioengineering: potential applications to glaucoma. Arch Ophthalmol. 2005 Dec; 123(12):1725-31. PMID: 16344446.
    Citations: 6     Fields:    Translation:HumansAnimals
  32. Young MJ. Stem cells in the mammalian eye: a tool for retinal repair. APMIS. 2005 Nov-Dec; 113(11-12):845-57. PMID: 16480454.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  33. Tomita M, Lavik E, Klassen H, Zahir T, Langer R, Young MJ. Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells. 2005 Nov-Dec; 23(10):1579-88. PMID: 16293582.
    Citations: 62     Fields:    Translation:AnimalsCells
  34. Warfvinge K, Kiilgaard JF, Lavik EB, Scherfig E, Langer R, Klassen HJ, Young MJ. Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation. Arch Ophthalmol. 2005 Oct; 123(10):1385-93. PMID: 16219730.
    Citations: 25     Fields:    Translation:AnimalsCells
  35. Burdick JA, Ward M, Liang E, Young MJ, Langer R. Stimulation of neurite outgrowth by neurotrophins delivered from degradable hydrogels. Biomaterials. 2006 Jan; 27(3):452-9. PMID: 16115674.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  36. Zahir T, Klassen H, Young MJ. Effects of ciliary neurotrophic factor on differentiation of late retinal progenitor cells. Stem Cells. 2005 Mar; 23(3):424-32. PMID: 15749937.
    Citations: 12     Fields:    Translation:AnimalsCells
  37. Klassen HJ, Ng TF, Kurimoto Y, Kirov I, Shatos M, Coffey P, Young MJ. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest Ophthalmol Vis Sci. 2004 Nov; 45(11):4167-73. PMID: 15505071.
    Citations: 109     Fields:    Translation:AnimalsCells
  38. Klassen H, Sakaguchi DS, Young MJ. Stem cells and retinal repair. Prog Retin Eye Res. 2004 Mar; 23(2):149-81. PMID: 15094129.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  39. Mizumoto H, Mizumoto K, Shatos MA, Klassen H, Young MJ. Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice. Vision Res. 2003 Jul; 43(16):1699-708. PMID: 12818339.
    Citations: 15     Fields:    Translation:AnimalsCells
  40. Klassen HJ, Imfeld KL, Kirov II, Tai L, Gage FH, Young MJ, Berman MA. Expression of cytokines by multipotent neural progenitor cells. Cytokine. 2003 May; 22(3-4):101-6. PMID: 12849709.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  41. Klassen H, Imfeld KL, Ray J, Young MJ, Gage FH, Berman MA. The immunological properties of adult hippocampal progenitor cells. Vision Res. 2003 Apr; 43(8):947-56. PMID: 12668064.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  42. Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ. Neural progenitor cells lack immunogenicity and resist destruction as allografts. Stem Cells. 2003; 21(4):405-16. PMID: 12832694.
    Citations: 53     Fields:    Translation:AnimalsCells
  43. Van Hoffelen SJ, Young MJ, Shatos MA, Sakaguchi DS. Incorporation of murine brain progenitor cells into the developing mammalian retina. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):426-34. PMID: 12506105.
    Citations: 34     Fields:    Translation:AnimalsCells
  44. Ng TF, Osawa H, Hori J, Young MJ, Streilein JW. Allogeneic neonatal neuronal retina grafts display partial immune privilege in the subcapsular space of the kidney. J Immunol. 2002 Nov 15; 169(10):5601-6. PMID: 12421938.
    Citations: 4     Fields:    Translation:AnimalsCells
  45. Mizumoto H, Mizumoto K, Whiteley SJO, Shatos M, Klassen H, Young MJ. Transplantation of Human Neural Progenitor Cells to the Vitreous Cavity of the Royal College of Surgeons Rat. Cell Transplant. 2001 Mar; 10(2):223-233. PMID: 28858580.
  46. Young MJ, Lee RK, Jhaveri S, Wurtman RJ. Intracellular and cell-surface distribution of amyloid precursor protein in cortical astrocytes. Brain Res Bull. 1999 Sep 01; 50(1):27-32. PMID: 10507468.
    Citations: 3     Fields:    Translation:AnimalsCells
  47. Young MJ, Lund RD. The retinal ganglion cells that drive the pupilloconstrictor response in rats. Brain Res. 1998 Mar 23; 787(2):191-202. PMID: 9518608.
    Citations: 8     Fields:    Translation:AnimalsCells
  48. Young MJ, Lund RD. Parameters of transplant-mediated pupilloconstriction in rats with unilateral olivary pretectal lesions. J Comp Neurol. 1997 Nov 17; 388(2):327-35. PMID: 9368845.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.