Harvard Catalyst Profiles

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Emily Beth Wong, M.D.

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Biography
2008 - 2010
Fogarty International Clinical Research Fellow
2014 - 2016
BWH/ASTMH Postdoctoral Fellowship in Tropical Infectious Diseases

Overview
TB remains the leading cause of infectious death in the world and is fueled by the HIV epidemic. I am interested in understanding the ways that HIV alters effective immunity against M. tuberculosis. It's particularly important to study the interactions of these two pathogens with the human immune system in the lung -- both the site of exposure to M.tb and the major site of disease. For the last several years my research has been based at the KwaZulu Natal Research Institute for Tuberculosis and HIV (K-RITH) in Durban, South Africa. I run a cohort that offers access to paired bronchoalveolar lavage (BAL) fluid and peripheral blood from people with well-defined states of HIV and TB co-infection. Current investigations focus on Mucosal Associated Invariant T (MAIT) cells -- a novel, abundant, class of antimicrobial innate T cells. Please contact me if you're interested in discussing collaboration or setting up a research experience.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08AI118538 (WONG, EMILY BETH) Jul 1, 2015 - Jun 30, 2020
    NIH/NIAID
    Studies of Mucosal Associated Invariant T (MAIT) cells in people with HIV, TB and HIV/TB co-infection in South Africa
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kazer SW, Aicher TP, Muema DM, Carroll SL, Ordovas-Montanes J, Miao VN, Tu AA, Ziegler CGK, Nyquist SK, Wong EB, Ismail N, Dong M, Moodley A, Berger B, Love JC, Dong KL, Leslie A, Ndhlovu ZM, Ndung'u T, Walker BD, Shalek AK. Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection. Nat Med. 2020 Apr; 26(4):511-518. PMID: 32251406.
    Citations:    
  2. Siedner MJ, Baisley K, Orne-Gliemann J, Pillay D, Koole O, Wong EB, Matthews P, Tanser F, Herbst K, Barnighausen T, Bachmann M. Linkage to primary care after home-based blood pressure screening in rural KwaZulu-Natal, South Africa: a population-based cohort study. BMJ Open. 2018 12 06; 8(12):e023369. PMID: 30530475.
    Citations:    Fields:    
  3. Mahamed D, Boulle M, Ganga Y, Mc Arthur C, Skroch S, Oom L, Catinas O, Pillay K, Naicker M, Rampersad S, Mathonsi C, Hunter J, Wong EB, Suleman M, Sreejit G, Pym AS, Lustig G, Sigal A. Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells. Elife. 2017 01 28; 6. PMID: 28130921.
    Citations: 7     Fields:    Translation:HumansCells
  4. Karat AS, Omar T, von Gottberg A, Tlali M, Chihota VN, Churchyard GJ, Fielding KL, Johnson S, Martinson NA, McCarthy K, Wolter N, Wong EB, Charalambous S, Grant AD. Autopsy Prevalence of Tuberculosis and Other Potentially Treatable Infections among Adults with Advanced HIV Enrolled in Out-Patient Care in South Africa. PLoS One. 2016; 11(11):e0166158. PMID: 27829072.
    Citations: 3     Fields:    Translation:Humans
  5. Wong EB, Ndung'u T, Kasprowicz VO. The role of mucosal-associated invariant T cells in infectious diseases. Immunology. 2017 Jan; 150(1):45-54. PMID: 27633333.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  6. Sullivan ZA, Wong EB, Ndung'u T, Kasprowicz VO, Bishai WR. Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV. EBioMedicine. 2015 Apr 01; 2(4):334-340. PMID: 26114158.
    Citations: 15     Fields:    
  7. Sharma PK, Wong EB, Napier RJ, Bishai WR, Ndung'u T, Kasprowicz VO, Lewinsohn DA, Lewinsohn DM, Gold MC. High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells. Immunology. 2015 Jul; 145(3):443-53. PMID: 25752900.
    Citations: 21     Fields:    Translation:HumansCells
  8. Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO. Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection. PLoS One. 2013; 8(12):e83474. PMID: 24391773.
    Citations: 27     Fields:    Translation:HumansCells
  9. Vestal ML, Wong EB, Milner DA, Gormley WB, Dunn IF. Cerebral melioidosis for the first time in the western hemisphere. J Neurosurg. 2013 Dec; 119(6):1591-5. PMID: 23767895.
    Citations: 3     Fields:    Translation:HumansCells
  10. Wong EB, Cohen KA, Bishai WR. Rising to the challenge: new therapies for tuberculosis. Trends Microbiol. 2013 Sep; 21(9):493-501. PMID: 23764389.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  11. Wong EB, Omar T, Setlhako GJ, Osih R, Feldman C, Murdoch DM, Martinson NA, Bangsberg DR, Venter WD. Causes of death on antiretroviral therapy: a post-mortem study from South Africa. PLoS One. 2012; 7(10):e47542. PMID: 23094059.
    Citations: 50     Fields:    Translation:HumansCells
  12. Gous N, Scott LE, Wong E, Omar T, Venter WD, Stevens W. Performance of the Roche LightCycler real-time PCR assay for diagnosing extrapulmonary tuberculosis. J Clin Microbiol. 2012 Jun; 50(6):2100-3. PMID: 22495565.
    Citations: 4     Fields:    Translation:HumansCells
  13. Corless IB, Wantland D, Bhengu B, McInerney P, Ncama B, Nicholas PK, McGibbon C, Wong E, Davis SM. HIV and tuberculosis in Durban, South Africa: adherence to two medication regimens. AIDS Care. 2009 Sep; 21(9):1106-13. PMID: 20024769.
    Citations: 5     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.