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Marian R. Neutra, Ph.D.


Adhesion and Uptake of IgA by Mouse Peyer's patch M Cells
Part Time/Continuation, 09/18/00 - 12/31/00
The Role of Tonsils in Vertical Transmission of HIV
Summer, 06/24/99 - 08/31/99
Uptake and Immune Response to IgA-antigen Complexes in Mice
Part Time/Continuation, 09/01/01 - 12/31/01
Adhesion of Lipopolysaccharide to M Cells Within Peyer's Patch Follicle-asociated Epithelium
Part Time/Continuation, 09/01/99 - 12/31/99
Adhesion and Uptake of 1gA by Mouse Duodenal/Jejunal Peyer's Patch M Cells after Intragastric 1gA Administration
Summer, 06/25/00 - 08/31/00
Analysis of Proinflammatory Expression in Peyer's Patch Follicle-associated Epithelium after Pathogen Exposure
Summer, 06/20/01 - 08/31/01
Uptake and Transcytosis of IgA-antigen Complexes by Peyer's Patch M Cells
Part Time, 04/01/01 - 06/20/01
The Role of Dendritic Cells in Presentation of Antigens Transported Across Mucosal Epithelia
Summer, 06/21/00 - 08/21/00
Expression of Lectin-like Molecules on the Apical Surfaces of Mouse Peyer's Patch M Cells
Summer, 06/28/99 - 08/20/99
Toll-like Receptor Agonists as Vaccine Adjuvants
Summer, 12/12/05 - 07/31/06

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R13AI040903 (NEUTRA, MARIAN R.) Mar 1, 1997 - Feb 28, 1998
    Role: Principal Investigator
  2. R01AI034757 (NEUTRA, MARIAN R.) Nov 1, 1993 - Oct 31, 2002
    Role: Principal Investigator
  3. U19AI033384 (TZIPORI, SAUL R) Sep 1, 1992 - Aug 31, 2000
    Role: Co-Principal Investigator
  4. R55AI029378 (NEUTRA, MARIAN R.) Sep 30, 1991 - Sep 29, 1993
    Role: Principal Investigator
  5. P30DK034854 (LENCER, WAYNE I) Sep 30, 1984 - Mar 31, 2026
    Integrated Epithelial and Muscosal Biology
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. PMID: 27687735; PMCID: PMC5043525.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  2. Kraehenbuhl JP, Neutra MR. Mucosal vaccines: where do we stand? Curr Top Med Chem. 2013; 13(20):2609-28. PMID: 24066889.
    Citations: 9     Fields:    Translation:Humans
  3. Chabot SM, Shawi M, Eaves-Pyles T, Neutra MR. Effects of flagellin on the functions of follicle-associated epithelium. J Infect Dis. 2008 Sep 15; 198(6):907-10. PMID: 18721059; PMCID: PMC5037956.
    Citations: 9     Fields:    Translation:AnimalsCells
  4. Anosova NG, Chabot S, Shreedhar V, Borawski JA, Dickinson BL, Neutra MR. Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches. Mucosal Immunol. 2008 Jan; 1(1):59-67. PMID: 19079161.
    Citations: 34     Fields:    Translation:AnimalsCells
  5. Mantis NJ, Palaia J, Hessell AJ, Mehta S, Zhu Z, Corthésy B, Neutra MR, Burton DR, Janoff EN. Inhibition of HIV-1 infectivity and epithelial cell transfer by human monoclonal IgG and IgA antibodies carrying the b12 V region. J Immunol. 2007 Sep 01; 179(5):3144-52. PMID: 17709529; PMCID: PMC2881690.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  6. Chabot SM, Chernin TS, Shawi M, Wagner J, Farrant S, Burt DS, Cyr S, Neutra MR. TLR2 activation by proteosomes promotes uptake of particulate vaccines at mucosal surfaces. Vaccine. 2007 Jul 20; 25(29):5348-58. PMID: 17582662.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  7. Chabot S, Wagner JS, Farrant S, Neutra MR. TLRs regulate the gatekeeping functions of the intestinal follicle-associated epithelium. J Immunol. 2006 Apr 01; 176(7):4275-83. PMID: 16547265.
    Citations: 63     Fields:    Translation:AnimalsCells
  8. Neutra MR, Kozlowski PA. Mucosal vaccines: the promise and the challenge. Nat Rev Immunol. 2006 Feb; 6(2):148-58. PMID: 16491139.
    Citations: 428     Fields:    Translation:HumansAnimals
  9. Helander A, Miller CL, Myers KS, Neutra MR, Nibert ML. Protective immunoglobulin A and G antibodies bind to overlapping intersubunit epitopes in the head domain of type 1 reovirus adhesin sigma1. J Virol. 2004 Oct; 78(19):10695-705. PMID: 15367636; PMCID: PMC516417.
    Citations: 9     Fields:    Translation:Cells
  10. Hutchings AB, Helander A, Silvey KJ, Chandran K, Lucas WT, Nibert ML, Neutra MR. Secretory immunoglobulin A antibodies against the sigma1 outer capsid protein of reovirus type 1 Lang prevent infection of mouse Peyer's patches. J Virol. 2004 Jan; 78(2):947-57. PMID: 14694126; PMCID: PMC368743.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  11. Fernandez MI, Thuizat A, Pedron T, Neutra M, Phalipon A, Sansonetti PJ. A newborn mouse model for the study of intestinal pathogenesis of shigellosis. Cell Microbiol. 2003 Jul; 5(7):481-91. PMID: 12814438.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  12. Helander A, Silvey KJ, Mantis NJ, Hutchings AB, Chandran K, Lucas WT, Nibert ML, Neutra MR. The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces. J Virol. 2003 Jul; 77(14):7964-77. PMID: 12829836; PMCID: PMC161912.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  13. Kozlowski PA, Neutra MR. The role of mucosal immunity in prevention of HIV transmission. Curr Mol Med. 2003 May; 3(3):217-28. PMID: 12699359.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  14. Shreedhar VK, Kelsall BL, Neutra MR. Cholera toxin induces migration of dendritic cells from the subepithelial dome region to T- and B-cell areas of Peyer's patches. Infect Immun. 2003 Jan; 71(1):504-9. PMID: 12496201.
    Citations: 42     Fields:    Translation:AnimalsCells
  15. Mantis NJ, Cheung MC, Chintalacharuvu KR, Rey J, Corthésy B, Neutra MR. Selective adherence of IgA to murine Peyer's patch M cells: evidence for a novel IgA receptor. J Immunol. 2002 Aug 15; 169(4):1844-51. PMID: 12165508.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  16. Kozlowski PA, Williams SB, Lynch RM, Flanigan TP, Patterson RR, Cu-Uvin S, Neutra MR. Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: influence of the menstrual cycle. J Immunol. 2002 Jul 01; 169(1):566-74. PMID: 12077289.
    Citations: 90     Fields:    Translation:Humans
  17. Zho F, Neutra MR. Antigen delivery to mucosa-associated lymphoid tissues using liposomes as a carrier. Biosci Rep. 2002 Apr; 22(2):355-69. PMID: 12428910.
    Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  18. Didierlaurent A, Sirard JC, Kraehenbuhl JP, Neutra MR. How the gut senses its content. Cell Microbiol. 2002 Feb; 4(2):61-72. PMID: 11896763.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  19. Neutra MR, Mantis NJ, Kraehenbuhl JP. Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat Immunol. 2001 Nov; 2(11):1004-9. PMID: 11685223.
    Citations: 145     Fields:    Translation:AnimalsCells
  20. Silvey KJ, Hutchings AB, Vajdy M, Petzke MM, Neutra MR. Role of immunoglobulin A in protection against reovirus entry into Murine Peyer's patches. J Virol. 2001 Nov; 75(22):10870-9. PMID: 11602727; PMCID: PMC114667.
    Citations: 32     Fields:    Translation:AnimalsCells
  21. Vajdy M, Veazey R, Tham I, deBakker C, Westmoreland S, Neutra M, Lackner A. Early immunologic events in mucosal and systemic lymphoid tissues after intrarectal inoculation with simian immunodeficiency virus. J Infect Dis. 2001 Oct 15; 184(8):1007-14. PMID: 11574915.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  22. Mantis NJ, Kozlowski PA, Mielcarz DW, Weissenhorn W, Neutra MR. Immunization of mice with recombinant gp41 in a systemic prime/mucosal boost protocol induces HIV-1-specific serum IgG and secretory IgA antibodies. Vaccine. 2001 Jul 16; 19(28-29):3990-4001. PMID: 11427275.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  23. Wang SW, Kozlowski PA, Schmelz G, Manson K, Wyand MS, Glickman R, Montefiori D, Lifson JD, Johnson RP, Neutra MR, Aldovini A. Effective induction of simian immunodeficiency virus-specific systemic and mucosal immune responses in primates by vaccination with proviral DNA producing intact but noninfectious virions. J Virol. 2000 Nov; 74(22):10514-22. PMID: 11044096; PMCID: PMC110926.
    Citations: 26     Fields:    Translation:AnimalsCellsPHPublic Health
  24. Vajdy M, Veazey RS, Knight HK, Lackner AA, Neutra MR. Differential effects of simian immunodeficiency virus infection on immune inductive and effector sites in the rectal mucosa of rhesus macaques. Am J Pathol. 2000 Aug; 157(2):485-95. PMID: 10934152; PMCID: PMC1850137.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Kozlowski PA, Lynch RM, Patterson RR, Cu-Uvin S, Flanigan TP, Neutra MR. Modified wick method using Weck-Cel sponges for collection of human rectal secretions and analysis of mucosal HIV antibody. J Acquir Immune Defic Syndr. 2000 Aug 01; 24(4):297-309. PMID: 11015145.
    Citations: 75     Fields:    Translation:Humans
  26. Cevallos AM, Zhang X, Waldor MK, Jaison S, Zhou X, Tzipori S, Neutra MR, Ward HD. Molecular cloning and expression of a gene encoding Cryptosporidium parvum glycoproteins gp40 and gp15. Infect Immun. 2000 Jul; 68(7):4108-16. PMID: 10858228.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  27. Mantis NJ, Frey A, Neutra MR. Accessibility of glycolipid and oligosaccharide epitopes on rabbit villus and follicle-associated epithelium. Am J Physiol Gastrointest Liver Physiol. 2000 Jun; 278(6):G915-23. PMID: 10859221.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  28. Lencer WI, Neutra MR. Salmonella pathogenesis: the trojan horse or the New York shuttle? Gastroenterology. 2000 Apr; 118(4):803-5. PMID: 10734034.
    Citations: 1     Fields:    Translation:HumansCells
  29. Kraehenbuhl JP, Neutra MR. Epithelial M cells: differentiation and function. Annu Rev Cell Dev Biol. 2000; 16:301-32. PMID: 11031239.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  30. Frey A, Mantis N, Kozlowski PA, Quayle AJ, Bajardi A, Perdomo JJ, Robey FA, Neutra MR. Immunization of mice with peptomers covalently coupled to aluminum oxide nanoparticles. Vaccine. 1999 Aug 06; 17(23-24):3007-19. PMID: 10462236.
    Citations: 7     Fields:    Translation:AnimalsCells
  31. Neutra MR, Mantis NJ, Frey A, Giannasca PJ. The composition and function of M cell apical membranes: implications for microbial pathogenesis. Semin Immunol. 1999 Jun; 11(3):171-81. PMID: 10381863.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  32. Kozlowski PA, Cu-Uvin S, Neutra MR, Flanigan TP. Mucosal vaccination strategies for women. J Infect Dis. 1999 May; 179 Suppl 3:S493-8. PMID: 10099127.
    Citations: 14     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
  33. Neutra MR. Interactions of viruses and microparticles with apical plasma membranes of M cells: implications for human immunodeficiency virus transmission. J Infect Dis. 1999 May; 179 Suppl 3:S441-3. PMID: 10099115.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  34. Giannasca PJ, Giannasca KT, Leichtner AM, Neutra MR. Human intestinal M cells display the sialyl Lewis A antigen. Infect Immun. 1999 Feb; 67(2):946-53. PMID: 9916113; PMCID: PMC96409.
    Citations: 39     Fields:    Translation:HumansCells
  35. Neutra MR. M cells in antigen sampling in mucosal tissues. Curr Top Microbiol Immunol. 1999; 236:17-32. PMID: 9893353.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  36. Lelouard H, Reggio H, Mangeat P, Neutra M, Montcourrier P. Mucin-related epitopes distinguish M cells and enterocytes in rabbit appendix and Peyer's patches. Infect Immun. 1999 Jan; 67(1):357-67. PMID: 9864237; PMCID: PMC96318.
    Citations: 11     Fields:    Translation:AnimalsCells
  37. Neutra MR. Current concepts in mucosal immunity. V Role of M cells in transepithelial transport of antigens and pathogens to the mucosal immune system. Am J Physiol. 1998 05; 274(5):G785-91. PMID: 9612256.
    Citations: 27     Fields:    Translation:AnimalsCells
  38. Neutra MR. HIV transmission and immune protection at mucosal surfaces. Adv Exp Med Biol. 1998; 452:169-75. PMID: 9889970.
    Citations:    Fields:    Translation:HumansCells
  39. Kraehenbuhl JP, Pringault E, Neutra MR. Review article: Intestinal epithelia and barrier functions. Aliment Pharmacol Ther. 1997 Dec; 11 Suppl 3:3-8; discussion 8-9. PMID: 9467973.
    Citations: 22     Fields:    Translation:Cells
  40. Frey A, Neutra MR, Robey FA. Peptomer aluminum oxide nanoparticle conjugates as systemic and mucosal vaccine candidates: synthesis and characterization of a conjugate derived from the C4 domain of HIV-1MN gp120. Bioconjug Chem. 1997 May-Jun; 8(3):424-33. PMID: 9177850.
    Citations: 8     Fields:    Translation:AnimalsCells
  41. Kozlowski PA, Cu-Uvin S, Neutra MR, Flanigan TP. Comparison of the oral, rectal, and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions of women. Infect Immun. 1997 Apr; 65(4):1387-94. PMID: 9119478.
    Citations: 112     Fields:    Translation:HumansCellsPHPublic Health
  42. Quesnel A, Cu-Uvin S, Murphy D, Ashley RL, Flanigan T, Neutra MR. Comparative analysis of methods for collection and measurement of immunoglobulins in cervical and vaginal secretions of women. J Immunol Methods. 1997 Mar 28; 202(2):153-61. PMID: 9107304.
    Citations: 10     Fields:    Translation:Humans
  43. Haneberg B, Kendall D, Apter FM, Neutra MR. Distribution of monoclonal antibodies in intestinal and urogenital secretions of mice bearing hybridoma 'backpack' tumours. Scand J Immunol. 1997 Feb; 45(2):151-9. PMID: 9042427.
    Citations: 4     Fields:    Translation:AnimalsCells
  44. Frey A, Neutra MR. Targeting of mucosal vaccines to Peyer's patch M cells. Behring Inst Mitt. 1997 Feb; (98):376-89. PMID: 9382762.
    Citations: 8     Fields:    Translation:HumansAnimals
  45. Corthésy B, Kaufmann M, Phalipon A, Peitsch M, Neutra MR, Kraehenbuhl JP. A pathogen-specific epitope inserted into recombinant secretory immunoglobulin A is immunogenic by the oral route. J Biol Chem. 1996 Dec 27; 271(52):33670-7. PMID: 8969237.
    Citations: 9     Fields:    Translation:AnimalsCells
  46. Frey A, Giannasca KT, Weltzin R, Giannasca PJ, Reggio H, Lencer WI, Neutra MR. Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting. J Exp Med. 1996 Sep 01; 184(3):1045-59. PMID: 9064322; PMCID: PMC2192803.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  47. Neutra MR, Frey A, Kraehenbuhl JP. Epithelial M cells: gateways for mucosal infection and immunization. Cell. 1996 Aug 09; 86(3):345-8. PMID: 8756716.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  48. Hendrickson BA, Rindisbacher L, Corthesy B, Kendall D, Waltz DA, Neutra MR, Seidman JG. Lack of association of secretory component with IgA in J chain-deficient mice. J Immunol. 1996 Jul 15; 157(2):750-4. PMID: 8752925.
    Citations: 20     Fields:    Translation:AnimalsCells
  49. Giannasca KT, Giannasca PJ, Neutra MR. Adherence of Salmonella typhimurium to Caco-2 cells: identification of a glycoconjugate receptor. Infect Immun. 1996 Jan; 64(1):135-45. PMID: 8557331.
    Citations: 30     Fields:    Translation:HumansCells
  50. Neutra MR, Pringault E, Kraehenbuhl JP. Antigen sampling across epithelial barriers and induction of mucosal immune responses. Annu Rev Immunol. 1996; 14:275-300. PMID: 8717516.
    Citations: 104     Fields:    Translation:HumansAnimals
  51. Hendrickson BA, Conner DA, Ladd DJ, Kendall D, Casanova JE, Corthesy B, Max EE, Neutra MR, Seidman CE, Seidman JG. Altered hepatic transport of immunoglobulin A in mice lacking the J chain. J Exp Med. 1995 Dec 01; 182(6):1905-11. PMID: 7500036; PMCID: PMC2192233.
    Citations: 33     Fields:    Translation:AnimalsCells
  52. Trahair JF, Wilson JM, Neutra MR. Identification of a marker antigen for the endocytic stage of intestinal development in rat, sheep, and human. J Pediatr Gastroenterol Nutr. 1995 Oct; 21(3):277-87. PMID: 8523211.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  53. Zhou F, Kraehenbuhl JP, Neutra MR. Mucosal IgA response to rectally administered antigen formulated in IgA-coated liposomes. Vaccine. 1995 May; 13(7):637-44. PMID: 7668033.
    Citations: 10     Fields:    Translation:AnimalsPHPublic Health
  54. Slauch JM, Mahan MJ, Michetti P, Neutra MR, Mekalanos JJ. Acetylation (O-factor 5) affects the structural and immunological properties of Salmonella typhimurium lipopolysaccharide O antigen. Infect Immun. 1995 Feb; 63(2):437-41. PMID: 7529745.
    Citations: 42     Fields:    Translation:Cells
  55. Speelman BA, Allen K, Grounds TL, Neutra MR, Kirchhausen T, Wilson JM. Molecular characterization of an apical early endosomal glycoprotein from developing rat intestinal epithelial cells. J Biol Chem. 1995 Jan 27; 270(4):1583-8. PMID: 7829488.
    Citations: 5     Fields:    Translation:AnimalsCells
  56. Kraehenbuhl JP, Kerneis S, Berdoz J, Corthésy B, Rindisbacher L, Corthésy-Theulaz I, Phalipon A, Neutra MR, Pringault E. Molecular events in production and transport of secretory IgA: a basis for design of reagents for passive immune protection. Vet Res. 1995; 26(3):231-2. PMID: 7795688.
    Citations:    Fields:    Translation:HumansAnimals
  57. Haneberg B, Kendall D, Amerongen HM, Apter FM, Neutra MR. The colon and rectum as inductor sites for local and distant mucosal immunity. Adv Exp Med Biol. 1995; 371A:107-9. PMID: 8525883.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  58. Giannasca PJ, Giannasca KT, Falk P, Gordon JI, Neutra MR. Regional differences in glycoconjugates of intestinal M cells in mice: potential targets for mucosal vaccines. Am J Physiol. 1994 Dec; 267(6 Pt 1):G1108-21. PMID: 7810658.
    Citations: 45     Fields:    Translation:AnimalsCells
  59. Amerongen HM, Wilson GA, Fields BN, Neutra MR. Proteolytic processing of reovirus is required for adherence to intestinal M cells. J Virol. 1994 Dec; 68(12):8428-32. PMID: 7525989; PMCID: PMC237317.
    Citations: 50     Fields:    Translation:AnimalsCells
  60. Michetti P, Porta N, Mahan MJ, Slauch JM, Mekalanos JJ, Blum AL, Kraehenbuhl JP, Neutra MR. Monoclonal immunoglobulin A prevents adherence and invasion of polarized epithelial cell monolayers by Salmonella typhimurium. Gastroenterology. 1994 Oct; 107(4):915-23. PMID: 7926481.
    Citations: 31     Fields:    Translation:AnimalsCells
  61. Reinhart FD, Phillips TE, Trahair JF, Neutra MR. Identification of R-GRAMP, a membrane glycoprotein of regulated secretory granules in primate cells. Eur J Cell Biol. 1994 Aug; 64(2):243-56. PMID: 7813512.
    Citations:    Fields:    Translation:HumansAnimalsCells
  62. Pakkanen R, Neutra M. Bovine colostrum ultrafiltrate: an effective supplement for the culture of mouse-mouse hybridoma cells. J Immunol Methods. 1994 Feb 28; 169(1):63-71. PMID: 8133074.
    Citations: 2     Fields:    Translation:AnimalsCells
  63. Haneberg B, Kendall D, Amerongen HM, Apter FM, Kraehenbuhl JP, Neutra MR. Induction of specific immunoglobulin A in the small intestine, colon-rectum, and vagina measured by a new method for collection of secretions from local mucosal surfaces. Infect Immun. 1994 Jan; 62(1):15-23. PMID: 8262621.
    Citations: 71     Fields:    Translation:AnimalsPHPublic Health
  64. Monath TP, Neutra MR. Special symposium on mucosal immunity: protection against pathogens. Introduction. Am J Trop Med Hyg. 1994; 50(5 Suppl):1-2. PMID: 8203717.
    Citations:    Fields:    Translation:HumansAnimals
  65. Neutra MR, Kraehenbuhl JP. Mucosal immunization via M cells for production of protective secretory IgA antibodies. Am J Trop Med Hyg. 1994; 50(5 Suppl):10-3. PMID: 8203718.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  66. Apter FM, Lencer WI, Finkelstein RA, Mekalanos JJ, Neutra MR. Monoclonal immunoglobulin A antibodies directed against cholera toxin prevent the toxin-induced chloride secretory response and block toxin binding to intestinal epithelial cells in vitro. Infect Immun. 1993 Dec; 61(12):5271-8. PMID: 7693598.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  67. Apter FM, Michetti P, Winner LS, Mack JA, Mekalanos JJ, Neutra MR. Analysis of the roles of antilipopolysaccharide and anti-cholera toxin immunoglobulin A (IgA) antibodies in protection against Vibrio cholerae and cholera toxin by use of monoclonal IgA antibodies in vivo. Infect Immun. 1993 Dec; 61(12):5279-85. PMID: 8225601.
    Citations: 53     Fields:    Translation:AnimalsCells
  68. Giannasca PJ, Neutra MR. Interactions of microorganisms with intestinal M cells: mucosal invasion and induction of secretory immunity. Infect Agents Dis. 1993 Aug; 2(4):242-8. PMID: 8173803.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  69. Hirt RP, Hughes GJ, Frutiger S, Michetti P, Perregaux C, Poulain-Godefroy O, Jeanguenat N, Neutra MR, Kraehenbuhl JP. Transcytosis of the polymeric Ig receptor requires phosphorylation of serine 664 in the absence but not the presence of dimeric IgA. Cell. 1993 Jul 30; 74(2):245-55. PMID: 8343953.
    Citations: 24     Fields:    Translation:AnimalsCells
  70. Neutra MR, Kraehenbuhl JP. The role of transepithelial transport by M cells in microbial invasion and host defense. J Cell Sci Suppl. 1993; 17:209-15. PMID: 8144698.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  71. Kraehenbuhl JP, Neutra MR. Molecular and cellular basis of immune protection of mucosal surfaces. Physiol Rev. 1992 Oct; 72(4):853-79. PMID: 1438580.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  72. Roth KA, Cohn SM, Rubin DC, Trahair JF, Neutra MR, Gordon JI. Regulation of gene expression in gastric epithelial cell populations of fetal, neonatal, and adult transgenic mice. Am J Physiol. 1992 Aug; 263(2 Pt 1):G186-97. PMID: 1514630.
    Citations: 6     Fields:    Translation:AnimalsCells
  73. Lencer WI, Delp C, Neutra MR, Madara JL. Mechanism of cholera toxin action on a polarized human intestinal epithelial cell line: role of vesicular traffic. J Cell Biol. 1992 Jun; 117(6):1197-1209. PMID: 1318883; PMCID: PMC2289494.
    Citations: 65     Fields:    Translation:HumansCells
  74. Kraehenbuhl JP, Neutra MR. Transepithelial transport and mucosal defence II: secretion of IgA. Trends Cell Biol. 1992 Jun; 2(6):170-4. PMID: 14731986.
    Citations: 11     Fields:    
  75. Neutra MR, Kraehenbuhl JP. Transepithelial transport and mucosal defence I: the role of M cells. Trends Cell Biol. 1992 May; 2(5):134-8. PMID: 14731967.
    Citations: 30     Fields:    
  76. Michetti P, Mahan MJ, Slauch JM, Mekalanos JJ, Neutra MR. Monoclonal secretory immunoglobulin A protects mice against oral challenge with the invasive pathogen Salmonella typhimurium. Infect Immun. 1992 May; 60(5):1786-92. PMID: 1373399.
    Citations: 108     Fields:    Translation:AnimalsCells
  77. Neutra MR, Kraehenbuhl JP. M cell-mediated antigen transport and monoclonal IgA antibodies for mucosal immune protection. Adv Exp Med Biol. 1992; 327:143-50. PMID: 1295335.
    Citations: 2     Fields:    Translation:HumansAnimals
  78. Amerongen HM, Weltzin R, Mack JA, Winner LS, Michetti P, Apter FM, Kraehenbuhl JP, Neutra MR. M cell-mediated antigen transport and monoclonal IgA antibodies for mucosal immune protection. Ann N Y Acad Sci. 1992; 664:18-26. PMID: 1456648.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  79. Wilson JM, Whitney JA, Neutra MR. Biogenesis of the apical endosome-lysosome complex during differentiation of absorptive epithelial cells in rat ileum. J Cell Sci. 1991 Sep; 100 ( Pt 1):133-43. PMID: 1795021.
    Citations: 17     Fields:    Translation:AnimalsCells
  80. Schaerer E, Neutra MR, Kraehenbuhl JP. Molecular and cellular mechanisms involved in transepithelial transport. J Membr Biol. 1991 Aug; 123(2):93-103. PMID: 1956074.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  81. Winner L, Mack J, Weltzin R, Mekalanos JJ, Kraehenbuhl JP, Neutra MR. New model for analysis of mucosal immunity: intestinal secretion of specific monoclonal immunoglobulin A from hybridoma tumors protects against Vibrio cholerae infection. Infect Immun. 1991 Mar; 59(3):977-82. PMID: 1705246.
    Citations: 69     Fields:    Translation:AnimalsCellsPHPublic Health
  82. Neutra M, Weltzin R, Winner L, Mack J, Michetti P, Morrison L, Fields BN, Mekalanos JJ, Kraehenbuhl JP. Identification and use of protective monoclonal IgA antibodies against viral and bacterial pathogens. Adv Exp Med Biol. 1991; 310:179-82. PMID: 1808995.
    Citations: 1     Fields:    Translation:AnimalsCells
  83. Michetti P, Hirt R, Weltzin R, Fasel N, Schaerer E, Neutra MR, Kraehenbühl JP. Production and use of monoclonal IgA antibodies complexed with recombinant secretory component for passive mucosal protection. Adv Exp Med Biol. 1991; 310:183-5. PMID: 1808996.
    Citations: 1     Fields:    Translation:AnimalsCells
  84. Amerongen HM, Weltzin R, Farnet CM, Michetti P, Haseltine WA, Neutra MR. Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS. J Acquir Immune Defic Syndr (1988). 1991; 4(8):760-5. PMID: 1856788.
    Citations: 60     Fields:    Translation:AnimalsCells
  85. Fujita M, Reinhart F, Neutra M. Convergence of apical and basolateral endocytic pathways at apical late endosomes in absorptive cells of suckling rat ileum in vivo. J Cell Sci. 1990 Oct; 97 ( Pt 2):385-94. PMID: 2277098.
    Citations: 23     Fields:    Translation:Animals
  86. Lencer WI, Reinhart FD, Neutra MR. Interaction of cholera toxin with cloned human goblet cells in monolayer culture. Am J Physiol. 1990 Jan; 258(1 Pt 1):G96-102. PMID: 2154122.
    Citations: 16     Fields:    Translation:HumansCells
  87. Trahair JF, Neutra MR, Gordon JI. Use of transgenic mice to study the routing of secretory proteins in intestinal epithelial cells: analysis of human growth hormone compartmentalization as a function of cell type and differentiation. J Cell Biol. 1989 Dec; 109(6 Pt 2):3231-42. PMID: 2689454; PMCID: PMC2115925.
    Citations: 18     Fields:    Translation:AnimalsCells
  88. Amerongen HM, Mack JA, Wilson JM, Neutra MR. Membrane domains of intestinal epithelial cells: distribution of Na+,K+-ATPase and the membrane skeleton in adult rat intestine during fetal development and after epithelial isolation. J Cell Biol. 1989 Nov; 109(5):2129-38. PMID: 2553743; PMCID: PMC2115838.
    Citations: 15     Fields:    Translation:AnimalsCells
  89. Phillips TE, Stenson WF, Neutra MR. Lipoxygenase metabolites of arachidonic acid do not induce mucus secretion from rabbit intestinal goblet cells in vitro. Prostaglandins Leukot Essent Fatty Acids. 1989 Jul; 37(1):51-5. PMID: 2762368.
    Citations: 1     Fields:    Translation:Animals
  90. Weltzin R, Lucia-Jandris P, Michetti P, Fields BN, Kraehenbuhl JP, Neutra MR. Binding and transepithelial transport of immunoglobulins by intestinal M cells: demonstration using monoclonal IgA antibodies against enteric viral proteins. J Cell Biol. 1989 May; 108(5):1673-85. PMID: 2541137; PMCID: PMC2115566.
    Citations: 52     Fields:    Translation:AnimalsCells
  91. Phillips TE, Phillips TL, Neutra MR. Cholinergic responsiveness of goblet cells during intestinal maturation. Biol Neonate. 1989; 55(4-5):197-203. PMID: 2719991.
    Citations: 1     Fields:    Translation:Animals
  92. Neutra MR, Wilson JM, Weltzin RA, Kraehenbuhl JP. Membrane domains and macromolecular transport in intestinal epithelial cells. Am Rev Respir Dis. 1988 Dec; 138(6 Pt 2):S10-6. PMID: 3202517.
    Citations: 1     Fields:    Translation:AnimalsCells
  93. Phillips TE, Huet C, Bilbo PR, Podolsky DK, Louvard D, Neutra MR. Human intestinal goblet cells in monolayer culture: characterization of a mucus-secreting subclone derived from the HT29 colon adenocarcinoma cell line. Gastroenterology. 1988 Jun; 94(6):1390-403. PMID: 3360261.
    Citations: 31     Fields:    Translation:HumansCells
  94. Wilson JM, Whitney JA, Neutra MR. Identification of an endosomal antigen specific to absorptive cells of suckling rat ileum. J Cell Biol. 1987 Aug; 105(2):691-703. PMID: 3305521; PMCID: PMC2114780.
    Citations: 23     Fields:    Translation:AnimalsCells
  95. Gonnella PA, Siminoski K, Murphy RA, Neutra MR. Transepithelial transport of epidermal growth factor by absorptive cells of suckling rat ileum. J Clin Invest. 1987 Jul; 80(1):22-32. PMID: 3496363; PMCID: PMC442197.
    Citations: 23     Fields:    Translation:Animals
  96. Neutra MR, Phillips TL, Mayer EL, Fishkind DJ. Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch. Cell Tissue Res. 1987 Mar; 247(3):537-46. PMID: 3568100.
    Citations: 61     Fields:    Translation:AnimalsCells
  97. Phillips TE, Phillips TL, Neutra MR. Macromolecules can pass through occluding junctions of rat ileal epithelium during cholinergic stimulation. Cell Tissue Res. 1987 Mar; 247(3):547-54. PMID: 3568101.
    Citations: 15     Fields:    Translation:AnimalsCells
  98. Siminoski K, Gonnella P, Bernanke J, Owen L, Neutra M, Murphy RA. Uptake and transepithelial transport of nerve growth factor in suckling rat ileum. J Cell Biol. 1986 Nov; 103(5):1979-90. PMID: 3023393; PMCID: PMC2114401.
    Citations: 22     Fields:    Translation:Animals
  99. Deitcher DL, Neutra MR, Mostov KE. Functional expression of the polymeric immunoglobulin receptor from cloned cDNA in fibroblasts. J Cell Biol. 1986 Mar; 102(3):911-9. PMID: 3753981; PMCID: PMC2114126.
    Citations: 12     Fields:    Translation:AnimalsCells
  100. Gonnella PA, Neutra MR. Glycoconjugate distribution and mobility on apical membranes of absorptive cells of suckling rat ileum in vivo. Anat Rec. 1985 Dec; 213(4):520-8. PMID: 4083533.
    Citations: 7     Fields:    Translation:AnimalsCells
  101. Neutra MR, Ciechanover A, Owen LS, Lodish HF. Intracellular transport of transferrin- and asialoorosomucoid-colloidal gold conjugates to lysosomes after receptor-mediated endocytosis. J Histochem Cytochem. 1985 Nov; 33(11):1134-44. PMID: 2997327.
    Citations: 26     Fields:    Translation:Cells
  102. Colony PC, Neutra MR. Macromolecular transport in the fetal rat intestine. Gastroenterology. 1985 Aug; 89(2):294-306. PMID: 4007421.
    Citations: 10     Fields:    Translation:AnimalsCells
  103. Phillips TE, Phillips TH, Neutra MR. Regulation of intestinal goblet cell secretion. III. Isolated intestinal epithelium. Am J Physiol. 1984 Dec; 247(6 Pt 1):G674-81. PMID: 6391203.
    Citations: 22     Fields:    Translation:AnimalsCells
  104. Specian RD, Neutra MR. Cytoskeleton of intestinal goblet cells in rabbit and monkey. The theca. Gastroenterology. 1984 Dec; 87(6):1313-25. PMID: 6541604.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  105. Phillips TE, Phillips TH, Neutra MR. Regulation of intestinal goblet cell secretion. IV. Electrical field stimulation in vitro. Am J Physiol. 1984 Dec; 247(6 Pt 1):G682-7. PMID: 6507624.
    Citations: 5     Fields:    Translation:Animals
  106. Gonnella PA, Neutra MR. Membrane-bound and fluid-phase macromolecules enter separate prelysosomal compartments in absorptive cells of suckling rat ileum. J Cell Biol. 1984 Sep; 99(3):909-17. PMID: 6470044; PMCID: PMC2113398.
    Citations: 36     Fields:    Translation:AnimalsCells
  107. Neutra MR, Phillips TL, Phillips TE. Regulation of intestinal goblet cells in situ, in mucosal explants and in the isolated epithelium. Ciba Found Symp. 1984; 109:20-39. PMID: 6394244.
    Citations: 7     Fields:    Translation:AnimalsCells
  108. Guerina NG, Kessler TW, Guerina VJ, Neutra MR, Clegg HW, Langermann S, Scannapieco FA, Goldmann DA. The role of pili and capsule in the pathogenesis of neonatal infection with Escherichia coli K1. J Infect Dis. 1983 Sep; 148(3):395-405. PMID: 6137504.
    Citations: 34     Fields:    Translation:AnimalsCells
  109. Colony PC, Neutra MR. Epithelial differentiation in the fetal rat colon. I. Plasma membrane phosphatase activities. Dev Biol. 1983 Jun; 97(2):349-63. PMID: 6303878.
    Citations: 14     Fields:    Translation:AnimalsCells
  110. Neutra MR, O'Malley LJ, Specian RD. Regulation of intestinal goblet cell secretion. II. A survey of potential secretagogues. Am J Physiol. 1982 Apr; 242(4):G380-7. PMID: 7065260.
    Citations: 28     Fields:    Translation:Animals
  111. Specian RD, Neutra MR. Regulation of intestinal goblet cell secretion. I. Role of parasympathetic stimulation. Am J Physiol. 1982 Apr; 242(4):G370-9. PMID: 7065259.
    Citations: 19     Fields:    Translation:Animals
  112. Madara JL, Neutra MR, Trier JS. Junctional complexes in fetal rat small intestine during morphogenesis. Dev Biol. 1981 Aug; 86(1):170-8. PMID: 7286391.
    Citations: 21     Fields:    Translation:AnimalsCells
  113. Murphy RA, Watson AY, McCarthy M, Papastavros M, Neutra M, Forssmann WG. Submandibular glands in mice with muscular dystrophy: studies with nerve growth factor. Anat Rec. 1981 Jun; 200(2):177-94. PMID: 7270919.
    Citations: 1     Fields:    Translation:Animals
  114. Specian RD, Neutra MR. The surface topography of the colonic crypt in rabbit and monkey. Am J Anat. 1981 Apr; 160(4):461-72. PMID: 7282569.
    Citations: 6     Fields:    Translation:Animals
  115. Specian RD, Neutra MR. Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine. J Cell Biol. 1980 Jun; 85(3):626-40. PMID: 7391135; PMCID: PMC2111470.
    Citations: 66     Fields:    Translation:Animals
  116. Madara JL, Trier JS, Neutra MR. Structural changes in the plasma membrane accompanying differentiation of epithelial cells in human and monkey small intestine. Gastroenterology. 1980 May; 78(5 Pt 1):963-75. PMID: 6769745.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  117. Neutra MR. Prokaryotic-eukaryotic cell junctions: attachment of spirochetes and flagellated bacteria to primate large intestinal cells. J Ultrastruct Res. 1980 Feb; 70(2):186-203. PMID: 6767039.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  118. Neutra MR. The use of human intestinal mucosa in organ culture for the study of cystic fibrosis. Birth Defects Orig Artic Ser. 1980; 16(2):261-73. PMID: 7213969.
    Citations: 3     Fields:    Translation:Humans
  119. Lake AM, Bloch KJ, Neutra MR, Walker WA. Intestinal goblet cell mucus release. II. In vivo stimulation by antigen in the immunized rat. J Immunol. 1979 Mar; 122(3):834-7. PMID: 448078.
    Citations: 15     Fields:    Translation:AnimalsPHPublic Health
  120. Neutra MR. Linear arrays of intramembrane particles on microvilli in primate large intestine. Anat Rec. 1979 Mar; 193(3):367-82. PMID: 106744.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  121. Neutra MR, Trier JS. Rectal mucosa in cystic fibrosis. Morphological features before and after short term organ culture. Gastroenterology. 1978 Oct; 75(4):701-10. PMID: 710839.
    Citations: 3     Fields:    Translation:Humans
  122. Neutra MR, Schaeffer SF. Membrane interactions between adjacent mucols secretion granules. J Cell Biol. 1977 Sep; 74(3):983-91. PMID: 409723; PMCID: PMC2110105.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  123. Neutra MR, Grand RJ, Trier JS. Glycoprotein synthesis, transport, and secretion by epithelial cells of human rectal mucosa: normal and cystic fibrosis. Lab Invest. 1977 May; 36(5):535-46. PMID: 865081.
    Citations: 30     Fields:    Translation:HumansCells
  124. Neutra MR, Maner JH, Mayoral LG. Effects of protein-calorie malnutrition on the jejunal mucosa of tetracycline-treated pigs. Am J Clin Nutr. 1974 Mar; 27(3):287-95. PMID: 4205494.
    Citations: 1     Fields:    Translation:AnimalsCells
  125. Neutra M, Leblond CP. The Golgi apparatus. Sci Am. 1969 Feb; 220(2):100-7. PMID: 4237402.
    Citations: 12     Fields:    Translation:AnimalsCells
  126. Neutra M, Leblond CP. Synthesis of the carbohydrate of mucus in the golgi complex as shown by electron microscope radioautography of goblet cells from rats injected with glucose-H3. J Cell Biol. 1966 Jul; 30(1):119-36. PMID: 5966171; PMCID: PMC2106987.
    Citations: 104     Fields:    Translation:AnimalsCells
  127. Neutra M, Leblond CP. Radioautographic comparison of the uptake of galactose-H and glucose-H3 in the golgi region of various cells secreting glycoproteins or mucopolysaccharides. J Cell Biol. 1966 Jul; 30(1):137-50. PMID: 4226008; PMCID: PMC2106996.
    Citations: 100     Fields:    Translation:AnimalsCells
  128. Rambourg A, Neutra M, Leblond CP. Presence of a "cell coat" rich in carbohydrate at the surface of cells in the rat. Anat Rec. 1966 Jan; 154(1):41-71. PMID: 4162458.
    Citations: 50     Fields:    Translation:AnimalsCells
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