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Alice Weaver Flaherty, M.D., Ph.D.

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Mentoring
completed student projects
Investigating the effect of deep brain stimulation on neural circuits perturbed in obsessive compulsive disorder: Neural activity during an avoidance-reward competition task
Summer, 06/14/10 - 08/20/10

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. K08NS002067 (FLAHERTY, ALICE W) Sep 30, 1998 - Aug 31, 2004
    NIH/NINDS
    Basal ganglia fMRI in normal and Parkinsonian patients
    Role: Principal Investigator
  2. F30MH010303 (FLAHERTY, ALICE W) Jan 27, 1993
    NIH/NIMH
    DEPARTMENT OF BRAIN &COGNITIVE SCIENCE, M.I.T.
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Patel SR, Herrington TM, Sheth SA, Mian M, Bick SK, Yang JC, Flaherty AW, Frank MJ, Widge AS, Dougherty D, Eskandar EN. Intermittent subthalamic nucleus deep brain stimulation induces risk-aversive behavior in human subjects. Elife. 2018 09 10; 7. PMID: 30198482.
    Citations:    Fields:    Translation:HumansCells
  2. Strand JJ, Warner LL, Kamdar MM, Flaherty AW, Jackson VA. It is Electric! Electroconvulsive Therapy for Refractory Central Pain and Comorbid Psychiatric Disease. J Palliat Med. 2018 Feb; 21(2):266-268. PMID: 29327970.
    Citations:    Fields:    
  3. Niethammer M, Tang CC, LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Sapan CV, Eidelberg D, During MJ, Kaplitt MG, Feigin A. Long-term follow-up of a randomized AAV2-GAD gene therapy trial for Parkinson's disease. JCI Insight. 2017 04 06; 2(7):e90133. PMID: 28405611.
    Citations: 2     Fields:    
  4. Perez DL, Young SS, King JN, Guarino AJ, Dworetzky BA, Flaherty A, Chemali Z, Caplan D, Dickerson BC. Preliminary Predictors of Initial Attendance, Symptom Burden, and Motor Subtype in a US Functional Neurological Disorders Clinic Population. Cogn Behav Neurol. 2016 Dec; 29(4):197-205. PMID: 27984257.
    Citations: 1     Fields:    Translation:Humans
  5. Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, Selkoe DJ, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman BT, Growdon JH, Sudarsky LR, Schlossmacher MG, Ravina B, Scherzer CR. Association between a-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain. 2015 Sep; 138(Pt 9):2659-71. PMID: 26220939.
    Citations: 16     Fields:    Translation:Humans
  6. Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 2013 Oct 22; 81(17):1531-7. PMID: 24068787.
    Citations: 22     Fields:    Translation:Humans
  7. Patel SR, Sheth SA, Martinez-Rubio C, Mian MK, Asaad WF, Gerrard JL, Kwon CS, Dougherty DD, Flaherty AW, Greenberg BD, Gale JT, Williams ZM, Eskandar EN. Studying task-related activity of individual neurons in the human brain. Nat Protoc. 2013 May; 8(5):949-57. PMID: 23598445.
    Citations: 2     Fields:    Translation:HumansCells
  8. Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, Unni VK, Hung AY, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Sudarsky LR, Growdon JH, Ivinson AJ, Hyman BT, Scherzer CR. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Mov Disord. 2011 Oct; 26(12):2283-6. PMID: 21953863.
    Citations: 9     Fields:    Translation:Humans
  9. Shields DC, Flaherty AW, Eskandar EN, Williams ZM. Ventral intermediate thalamic stimulation for monoclonal gammopathy-associated tremor: case report. Neurosurgery. 2011 May; 68(5):E1464-7. PMID: 21311371.
    Citations:    Fields:    Translation:Humans
  10. LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Van Meter L, Sapan CV, During MJ, Kaplitt MG, Feigin A. AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. Lancet Neurol. 2011 Apr; 10(4):309-19. PMID: 21419704.
    Citations: 154     Fields:    Translation:Humans
  11. Flaherty AW. Brain illness and creativity: mechanisms and treatment risks. Can J Psychiatry. 2011 Mar; 56(3):132-43. PMID: 21443820.
    Citations: 9     Fields:    Translation:Humans
  12. Brown HE, Flaherty AW, Goff DC, Freudenreich O. A case of dramatic improvement of severe tardive dyskinesia after switch to aripiprazole. Prim Care Companion CNS Disord. 2011; 13(6). PMID: 22454797.
    Citations:    Fields:    
  13. Ducharme S, Flaherty AW, Seiner SJ, Dougherty DD, Morales OG. Temporary interruption of deep brain stimulation for Parkinson's disease during outpatient electroconvulsive therapy for major depression: a novel treatment strategy. J Neuropsychiatry Clin Neurosci. 2011; 23(2):194-7. PMID: 21677249.
    Citations: 4     Fields:    Translation:Humans
  14. Quinn DK, Flaherty AW, Herman JB, Kleinschmidt TL. Over the rainbow: a case of traumatic brain injury. Harv Rev Psychiatry. 2010 Jan-Feb; 18(1):56-66. PMID: 20047461.
    Citations:    Fields:    Translation:Humans
  15. Shields DC, Asaad W, Eskandar EN, Jain FA, Cosgrove GR, Flaherty AW, Cassem EH, Price BH, Rauch SL, Dougherty DD. Prospective assessment of stereotactic ablative surgery for intractable major depression. Biol Psychiatry. 2008 Sep 15; 64(6):449-54. PMID: 18486107.
    Citations: 8     Fields:    Translation:Humans
  16. Flaherty AW. Movement disorders. In Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch S, eds., Massachusetts General Hospital Comprehensive Clinical Psychiatry, CD-ROM edition. 2008.
  17. Flaherty, AW. Movement disorders. Stern TA, Rosenbaum JF, Fava M, Biederman J, Rauch S, eds., Massachusetts General Hospital Comprehensive Clinical Psychiatry. 2008.
  18. Flaherty AW. Playing doctor well. Neurology. 2008 Mar 11; 70(11):826-7. PMID: 18332340.
    Citations:    Fields:    Translation:Humans
  19. Flaherty AW. Interdisciplinary inspiration. Nature. 2008; 451(7176):246.
  20. Flaherty AW. Video edition of The Luck of the Loch Ness Monster. 2008.
  21. Patel S. Hester T, Hughes R, Huggins N, Flaherty A, Standaert D, Growdon J, Bonato P. Processing wearable sensor data to optimize deep-brain stimulation. IEEE Pervasive Computing. 2008; 7:56-61.
  22. Flaherty A. A brief proposal, 150 words. Nature. 2007 Dec 20; 450(7173):1156. PMID: 18097375.
    Citations:    Fields:    Translation:Humans
  23. Shields DC, Cheng ML, Flaherty AW, Gale JT, Eskandar EN. Microelectrode-guided deep brain stimulation for Tourette syndrome: within-subject comparison of different stimulation sites. Stereotact Funct Neurosurg. 2008; 86(2):87-91. PMID: 18073521.
    Citations: 19     Fields:    Translation:Humans
  24. Flaherty AW, Jacobs A, Lethem J, Levy F, Oppenhiem L, Reyes P,. Hypergraphia and Hypographia, "Diseases" of the Written Word," 2-hour video of roundtable discussion. 2007.
  25. Gale JT, Amirnovin R, Williams ZM, Flaherty AW, Eskandar EN. From symphony to cacophony: pathophysiology of the human basal ganglia in Parkinson disease. Neurosci Biobehav Rev. 2008; 32(3):378-87. PMID: 17466375.
    Citations: 20     Fields:    Translation:Humans
  26. Kraft E, Chen AW, Flaherty AW, Blood AJ, Kwong KK, Jenkins BG. The role of the basal ganglia in bimanual coordination. Brain Res. 2007 Jun 02; 1151:62-73. PMID: 17448452.
    Citations: 14     Fields:    Translation:Humans
  27. Flaherty AW, Rost NS. . . The Massachusetts General Hospital Handbook of Neurology, 2nd expanded edition. 2007.
  28. Flaherty AW. Psychosocial effects of deep brain stimulation, or the perils of getting well. Journal Watch Neurology. 2007.
  29. Flaherty AW, illus. Magoon S. The Luck of the Loch Ness Monster. 2007.
  30. Flaherty AW, Magoon S. The Luck of the Loch Ness Monster: A Tale of Picky Eating. 2007.
  31. Flaherty AW. All the rage. The Harvard Medical School Bulletin. 2006; autumn.
  32. Flaherty AW. The proctologist wears Prada. The Harvard Medical School Bulletin. 2006; spring.
  33. Flaherty, AW. Trans: Yoshida T. [Japanese trans. of TMD]. 2006.
  34. Koss AM, Tramo MJ, Flaherty AW, Young AB. Effect of auditory stimulation with popular music on visuomotor integration and gait in Parkinson’ s disease. American Academy of Neurology Annual Meeting. 2006.
  35. Flaherty AW. Frontotemporal and dopaminergic control of idea generation and creative drive. J Comp Neurol. 2005 Dec 05; 493(1):147-53. PMID: 16254989.
    Citations: 36     Fields:    Translation:Humans
  36. Flaherty, AW. Just got to write this down. The New Scientist. 2005; 48-49.
  37. Flaherty AW, Williams ZM, Amirnovin R, Kasper E, Rauch SL, Cosgrove GR, Eskandar EN. Deep brain stimulation of the anterior internal capsule for the treatment of Tourette syndrome: technical case report. Neurosurgery. 2005 Oct; 57(4 Suppl):E403; discussion E403. PMID: 16234657.
    Citations: 34     Fields:    Translation:Humans
  38. Flaherty AW. Bedside manners. The Harvard Medical School Bulletin. 2005; autumn.
  39. Flaherty AW, trans. Fleckenstein K. Die Mitternachtskrankheit - Warum Schriftsteller schreiben müssen. Schreibzwang - Schreibrausch - Schreibblockade und das kreative Gehirn. [German trans. of TMD]. 2004.
  40. Blood AJ, Flaherty AW, Choi JK, Hochberg FH, Greve DN, Bonmassar G, Rosen BR, Jenkins BG. Basal ganglia activity remains elevated after movement in focal hand dystonia. Ann Neurol. 2004 May; 55(5):744-8. PMID: 15122718.
    Citations: 27     Fields:    Translation:Humans
  41. Flaherty AW. Mood and creative state influences on temporal perception. International Psychoanalytical Association Biannual Meeting. 2004.
  42. Flaherty AW. The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain. 2004.
  43. Flaherty, AW. Monkey business. The Harvard Medical School Bulletin. 2004; autumn.
  44. Flaherty, AW, Akbarian S, MA Samuels. Stroke. T. A. Stern and J. B. Herman, eds., Psychiatry: Update and Board Preparation, 2nd ed. 2004.
  45. Flaherty AW. The Midnight Disease: The Drive to Write, Writer's Block, and the Creative Brain. 2004.
  46. Flaherty, AW, Akbarian S, MA Samuels. Movement disorders. T. A. Stern and J. B. Herman, eds., Psychiatry: Update and Board Preparation, 2nd ed. 2004.
  47. Eskandar EN, Flaherty A, Cosgrove GR, Shinobu LA, Barker FG. Surgery for Parkinson disease in the United States, 1996 to 2000: practice patterns, short-term outcomes, and hospital charges in a nationwide sample. J Neurosurg. 2003 Nov; 99(5):863-71. PMID: 14609166.
    Citations: 11     Fields:    Translation:Humans
  48. Flaherty AW. Writing like crazy: a word on the brain. Chronicle of Higher Education. 2003; 50(13):1-6.
  49. Flaherty AW. CD-ROM edition of The Massachusetts General Hospital Handbook of Neurology. 2002.
  50. Flaherty AW. PDA edition of The Massachusetts General Hospital Handbook of Neurology. 2002.
  51. Flaherty, AW. Neurologia [Spanish trans. of TMGHHN]. 2001.
  52. Flaherty AW. [Japanese trans. of TMGHHN]. 2001.
  53. Flaherty, A. W. , J. Lester, S. Prady, L. H. Schwamm (2001). . Baker Educational Colloquium: The Harvard WEB-MED Project and The MGH Handbook of Neurology. 2001.
  54. Flaherty AW, Lester J, Prady S, Schwamm LS. An interactive portable neurological tool. American Academy of Neurology Annual Meeting. 2001.
  55. Scholz VH, Flaherty AW, Kraft E, Keltner JR, Kwong KK, Chen YI, Rosen BR, Jenkins BG. Laterality, somatotopy and reproducibility of the basal ganglia and motor cortex during motor tasks. Brain Res. 2000 Oct 06; 879(1-2):204-15. PMID: 11011024.
    Citations: 21     Fields:    Translation:Humans
  56. Flaherty AW. The Massachusetts General Hospital Handbook of Neurology. 2000.
  57. Flaherty AW, Graybiel AM. Motor and somatosensory corticostriatal projection magnifications in the squirrel monkey. J Neurophysiol. 1995 Dec; 74(6):2638-48. PMID: 8747221.
    Citations: 12     Fields:    Translation:Animals
  58. Graybiel AM, Aosaki T, Flaherty AW, Kimura M. The basal ganglia and adaptive motor control. Science. 1994 Sep 23; 265(5180):1826-31. PMID: 8091209.
    Citations: 228     Fields:    Translation:HumansAnimalsCells
  59. Flaherty AW, Graybiel AM. Input-output organization of the sensorimotor striatum in the squirrel monkey. J Neurosci. 1994 Feb; 14(2):599-610. PMID: 7507981.
    Citations: 43     Fields:    Translation:Animals
  60. Flaherty AW, Graybiel AM. Anatomy of the basal ganglia. Marsden CD, Fahn S, eds. Movement Disorders, III. 1994; 3-28.
  61. Flaherty AW. Contributions of motor and somatosensory cortex to movement control in the primate striatum. 1994.
  62. Flaherty AW, Graybiel AM. Output architecture of the primate putamen. J Neurosci. 1993 Aug; 13(8):3222-37. PMID: 7688037.
    Citations: 17     Fields:    Translation:AnimalsCells
  63. Flaherty AW, Graybiel AM. Two input systems for body representations in the primate striatal matrix: experimental evidence in the squirrel monkey. J Neurosci. 1993 Mar; 13(3):1120-37. PMID: 7680067.
    Citations: 48     Fields:    Translation:AnimalsCells
  64. Flaherty AW. Multiple stages of sensorimotor processing in the primate basal ganglia. 1992.
  65. Flaherty AW, Graybiel AM. Corticostriatal transformations in the primate somatosensory system. Projections from physiologically mapped body-part representations. J Neurophysiol. 1991 Oct; 66(4):1249-63. PMID: 1722244.
    Citations: 40     Fields:    Translation:Animals
  66. Graybiel AM, Flaherty AW, Gimenez-Amaya JM. Striosomes and matrisomes. Bernardi G, Carpenter MB, Di Chiari G, eds. The Basal Ganglia, III. 1991.
  67. Flaherty AW . Standard laboratory methods. Beck WS, ed. Hematology, fifth ed. 1991.
  68. Flaherty AW. Mirror, mirror .. Science. 1989 Aug 18; 245(4919):693. PMID: 17791695.
    Citations:    Fields:    
  69. Godley BF, Flaherty AW, Wurtman RJ. The effects of light on retinal dopamine in the ra. Annals of the New York Academy of Sciences. 1985; 453:383-384.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.