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Nora Amanda Barrett, M.D.

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Overview
Our lab is interested in defining the role of innate immunity in homeostasis, repair, and disease in the respiratory tract, where environmental determinants play a key role in both immunopathogenesis and health. Using biochemical, molecular, and genomic approaches, we focus on the cellular and molecular networks underlying the initiation and persistence of type 2 immunity at mucosal sites. Our ultimate goal is to understand innate immune sensing in the respiratory tract and key regulatory features that may treat or prevent diseases such as asthma.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI134989 (BARRETT, NORA AMANDA) Jan 1, 2019 - Dec 31, 2023
    NIH/NIAID
    Type 2 Immunity Elicited Through an LTE4/GPR99-Dependent Pathway
    Role: Principal Investigator
  2. R56AI134989 (BARRETT, NORA AMANDA) Feb 1, 2018 - Jan 31, 2019
    NIH/NIAID
    Type 2 Mucosal Inflammation Elicited Through an LTE4/GPR99-Dependent Pathway
    Role: Principal Investigator
  3. W81XWH-17-1-0527 (BARRETT, NORA AMANDA) Sep 1, 2017 - Aug 31, 2020
    Department of Defense
    Role of the Leukotriene E4 Receptor GPR99 in Asthma
    Role: Principal Investigator
  4. R01HL120952 (BARRETT, NORA AMANDA) Jan 1, 2014 - Dec 31, 2018
    NIH/NHLBI
    Allergic Pulmonary Inflammation Through the Dectin-2 Pathway
    Role: Principal Investigator
  5. U19AI095219 (BOYCE, JOSHUA A) Jul 15, 2011 - Jun 30, 2021
    NIH/NIAID
    Pathophysiologic and Therapeutic Mechanisms in Aspirin Exacerbated Respiratory Disease
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, Cao Y, Yousif AS, Bals J, Hauser BM, Feldman J, Muus C, Wadsworth MH, Kazer SW, Hughes TK, Doran B, Gatter GJ, Vukovic M, Taliaferro F, Mead BE, Guo Z, Wang JP, Gras D, Plaisant M, Ansari M, Angelidis I, Adler H, Sucre JMS, Taylor CJ, Lin B, Waghray A, Mitsialis V, Dwyer DF, Buchheit KM, Boyce JA, Barrett NA, Laidlaw TM, Carroll SL, Colonna L, Tkachev V, Peterson CW, Yu A, Zheng HB, Gideon HP, Winchell CG, Lin PL, Bingle CD, Snapper SB, Kropski JA, Theis FJ, Schiller HB, Zaragosi LE, Barbry P, Leslie A, Kiem HP, Flynn JL, Fortune SM, Berger B, Finberg RW, Kean LS, Garber M, Schmidt AG, Lingwood D, Shalek AK, Ordovas-Montanes J. SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues. Cell. 2020 05 28; 181(5):1016-1035.e19. PMID: 32413319.
    Citations:    
  2. Buchheit KM, Dwyer DF, Ordovas-Montanes J, Katz HR, Lewis E, Vukovic M, Lai J, Bankova LG, Bhattacharyya N, Shalek AK, Barrett NA, Boyce JA, Laidlaw TM. IL-5Ra marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2020 Jun; 145(6):1574-1584. PMID: 32199912.
    Citations:    
  3. McGinty JW, Ting HA, Billipp TE, Nadjsombati MS, Khan DM, Barrett NA, Liang HE, Matsumoto I, von Moltke J. Tuft-Cell-Derived Leukotrienes Drive Rapid Anti-helminth Immunity in the Small Intestine but Are Dispensable for Anti-protist Immunity. Immunity. 2020 03 17; 52(3):528-541.e7. PMID: 32160525.
    Citations:    
  4. Bankova LG, Barrett NA. Epithelial cell function and remodeling in nasal polyposis. Ann Allergy Asthma Immunol. 2020 04; 124(4):333-341. PMID: 32007569.
    Citations:    
  5. Ualiyeva S, Hallen N, Kanaoka Y, Ledderose C, Matsumoto I, Junger WG, Barrett NA, Bankova LG. Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2. Sci Immunol. 2020 01 17; 5(43). PMID: 31953256.
    Citations:    
  6. Barrett NA, Shalek AK. Revisiting airway epithelial remodeling in type 2 immunity: Beyond goblet cell metaplasia. J Allergy Clin Immunol. 2019 11; 144(5):1158-1160. PMID: 31600548.
    Citations:    
  7. Ualiyeva S, Yoshimoto E, Barrett NA, Bankova LG. Isolation and Quantitative Evaluation of Brush Cells from Mouse Tracheas. J Vis Exp. 2019 06 12; (148). PMID: 31259891.
    Citations:    
  8. Liu T, Barrett NA, Kanaoka Y, Buchheit K, Laidlaw TM, Garofalo D, Lai J, Katz HR, Feng C, Boyce JA. Cysteinyl leukotriene receptor 2 drives lung immunopathology through a platelet and high mobility box 1-dependent mechanism. Mucosal Immunol. 2019 05; 12(3):679-690. PMID: 30664709.
    Citations:    Fields:    
  9. Bankova LG, Dwyer DF, Yoshimoto E, Ualiyeva S, McGinty JW, Raff H, von Moltke J, Kanaoka Y, Frank Austen K, Barrett NA. The cysteinyl leukotriene 3 receptor regulates expansion of IL-25-producing airway brush cells leading to type 2 inflammation. Sci Immunol. 2018 10 05; 3(28). PMID: 30291131.
    Citations:    Fields:    
  10. Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, Wadsworth MH, Hughes TK, Kazer SW, Yoshimoto E, Cahill KN, Bhattacharyya N, Katz HR, Berger B, Laidlaw TM, Boyce JA, Barrett NA, Shalek AK. Allergic inflammatory memory in human respiratory epithelial progenitor cells. Nature. 2018 08; 560(7720):649-654. PMID: 30135581.
    Citations:    Fields:    
  11. Liu T, Barrett NA, Kanaoka Y, Yoshimoto E, Garofalo D, Cirka H, Feng C, Boyce JA. Type 2 Cysteinyl Leukotriene Receptors Drive IL-33-Dependent Type 2 Immunopathology and Aspirin Sensitivity. J Immunol. 2018 02 01; 200(3):915-927. PMID: 29282304.
    Citations: 1     Fields:    Translation:AnimalsCells
  12. von Moltke J, O'Leary CE, Barrett NA, Kanaoka Y, Austen KF, Locksley RM. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s. J Exp Med. 2017 01; 214(1):27-37. PMID: 28011865.
    Citations: 14     Fields:    Translation:AnimalsCells
  13. Lee MJ, Yoshimoto E, Saijo S, Iwakura Y, Lin X, Katz HR, Kanaoka Y, Barrett NA. Phosphoinositide 3-Kinase d Regulates Dectin-2 Signaling and the Generation of Th2 and Th17 Immunity. J Immunol. 2016 07 01; 197(1):278-87. PMID: 27194783.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Bankova LG, Lai J, Yoshimoto E, Boyce JA, Austen KF, Kanaoka Y, Barrett NA. Leukotriene E4 elicits respiratory epithelial cell mucin release through the G-protein-coupled receptor, GPR99. Proc Natl Acad Sci U S A. 2016 May 31; 113(22):6242-7. PMID: 27185938.
    Citations: 8     Fields:    Translation:AnimalsCells
  15. Dwyer DF, Barrett NA, Austen KF. Expression profiling of constitutive mast cells reveals a unique identity within the immune system. Nat Immunol. 2016 Jul; 17(7):878-87. PMID: 27135604.
    Citations: 26     Fields:    Translation:AnimalsCells
  16. Sloane D, Govindarajulu U, Harrow-Mortelliti J, Barry W, Hsu FI, Hong D, Laidlaw T, Palis R, Legere H, Bunyavanich S, Breslow R, Wesemann D, Barrett N, Brennan P, Chong HJ, Liu A, Fernandez J, Fanning L, Kyin T, Cahill K, Bankova L, Lynch A, Berlin S, Campos S, Fuchs C, Mayer R, Matulonis U, Castells M. Safety, Costs, and Efficacy of Rapid Drug Desensitizations to Chemotherapy and Monoclonal Antibodies. J Allergy Clin Immunol Pract. 2016 May-Jun; 4(3):497-504. PMID: 26895621.
    Citations: 5     Fields:    Translation:Humans
  17. Barrett NA, Austen KF. Licensed to Ill: IL-9 Generation in Immature Mast Cells Permits Food-Elicited Anaphylaxis. Immunity. 2015 Oct 20; 43(4):626-8. PMID: 26488812.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Liu T, Kanaoka Y, Barrett NA, Feng C, Garofalo D, Lai J, Buchheit K, Bhattacharya N, Laidlaw TM, Katz HR, Boyce JA. Aspirin-Exacerbated Respiratory Disease Involves a Cysteinyl Leukotriene-Driven IL-33-Mediated Mast Cell Activation Pathway. J Immunol. 2015 Oct 15; 195(8):3537-45. PMID: 26342029.
    Citations: 14     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  19. Boyce JA, Barrett NA. Cysteinyl leukotrienes: an innate system for epithelial control of airway smooth muscle proliferation? Am J Respir Crit Care Med. 2015 Mar 01; 191(5):496-7. PMID: 25723820.
    Citations:    Fields:    Translation:HumansAnimals
  20. Tjota MY, Hrusch CL, Blaine KM, Williams JW, Barrett NA, Sperling AI. Signaling through FcR?-associated receptors on dendritic cells drives IL-33-dependent TH2-type responses. J Allergy Clin Immunol. 2014 Sep; 134(3):706-713.e8. PMID: 25088053.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  21. Cardet JC, White AA, Barrett NA, Feldweg AM, Wickner PG, Savage J, Bhattacharyya N, Laidlaw TM. Alcohol-induced respiratory symptoms are common in patients with aspirin exacerbated respiratory disease. J Allergy Clin Immunol Pract. 2014 Mar-Apr; 2(2):208-13.. PMID: 24607050.
    Citations: 7     Fields:    Translation:Humans
  22. Parsons MW, Li L, Wallace AM, Lee MJ, Katz HR, Fernandez JM, Saijo S, Iwakura Y, Austen KF, Kanaoka Y, Barrett NA. Dectin-2 regulates the effector phase of house dust mite-elicited pulmonary inflammation independently from its role in sensitization. J Immunol. 2014 Feb 15; 192(4):1361-71. PMID: 24453247.
    Citations: 13     Fields:    Translation:AnimalsCells
  23. Barrett NA, Boyce JA. Activation of group 2 innate lymphoid cells: a new role for cysteinyl leukotrienes. J Allergy Clin Immunol. 2013 Jul; 132(1):214-6. PMID: 23810099.
    Citations:    
  24. Barrett NA, Fernandez JM, Maekawa A, Xing W, Li L, Parsons MW, Austen KF, Kanaoka Y. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J Immunol. 2012 Nov 01; 189(9):4556-65. PMID: 23002438.
    Citations: 12     Fields:    Translation:AnimalsCells
  25. Barrett NA, Rahman OM, Fernandez JM, Parsons MW, Xing W, Austen KF, Kanaoka Y. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med. 2011 Mar 14; 208(3):593-604. PMID: 21357742.
    Citations: 61     Fields:    Translation:AnimalsCells
  26. Breslow RG, Rao JJ, Xing W, Hong DI, Barrett NA, Katz HR. Inhibition of Th2 adaptive immune responses and pulmonary inflammation by leukocyte Ig-like receptor B4 on dendritic cells. J Immunol. 2010 Jan 15; 184(2):1003-13. PMID: 19966208.
    Citations: 2     Fields:    Translation:AnimalsCells
  27. Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity. 2009 Sep 18; 31(3):425-37. PMID: 19766085.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  28. Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol. 2009 Jan 15; 182(2):1119-28. PMID: 19124755.
    Citations: 83     Fields:    Translation:AnimalsCells
  29. Castells MC, Tennant NM, Sloane DE, Hsu FI, Barrett NA, Hong DI, Laidlaw TM, Legere HJ, Nallamshetty SN, Palis RI, Rao JJ, Berlin ST, Campos SM, Matulonis UA. Hypersensitivity reactions to chemotherapy: outcomes and safety of rapid desensitization in 413 cases. J Allergy Clin Immunol. 2008 Sep; 122(3):574-80. PMID: 18502492.
    Citations: 43     Fields:    Translation:Humans
  30. Kim D, Hsu F, Barrett NA, Friend D, Grenningloh R, Ho I, Al-Garawi A, Lora J, Lam B, Austen K, Kanaoka Y. . Leukotrienes are required for development of Th2 Pulmonary Inflammation. Journal of Immunology. 2006; 176(7):4440-4448.
  31. Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol. 2006 Apr 01; 176(7):4440-8. PMID: 16547282.
    Citations: 52     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.