Harvard Catalyst Profiles

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David Morse Livingston, M.D.

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Title
Institution
Department

Mentoring
Identifying the region of BRCA1 that interacts with RFC/Rad17/Rad9 complexes to repair stalled replication forks
Summer, 06/13/11 - 08/01/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA242143 (LIVINGSTON, DAVID MORSE) Aug 7, 2019 - Jul 31, 2026
    NIH
    Deciphering the mechanism underlying BRCA1 breast cancer development
    Role: Principal Investigator
  2. R01CA136512 (LIVINGSTON, DAVID MORSE) Jul 1, 2009 - Dec 31, 2020
    NIH
    BRCA1 Function in Post-Damage Nuclear Foci
    Role: Principal Investigator
  3. R01CA103920 (LIVINGSTON, DAVID MORSE) May 5, 2004 - Feb 28, 2010
    NIH
    BRCA1 and the Inactive X Chromosome
    Role: Principal Investigator
  4. P50CA089393 (WINER, ERIC P) Sep 30, 2000 - Aug 31, 2012
    NIH
    Dana-Farber/Harvard SPORE in Breast Cancer
    Role: Co-Principal Investigator
  5. U01CA084995 (LIVINGSTON, DAVID MORSE) Sep 30, 1999 - Mar 31, 2005
    NIH
    GENE EXPRESSION ANALYSIS OF PROSTATE &LUNG CANCER
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vohhodina J, Goehring LJ, Liu B, Kong Q, Botchkarev VV, Huynh M, Liu Z, Abderazzaq FO, Clark AP, Ficarro SB, Marto JA, Hatchi E, Livingston DM. BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage. Nat Commun. 2021 06 10; 12(1):3542. PMID: 34112789.
    Citations:    Fields:    Translation:HumansCells
  2. Hatchi E, Goehring L, Landini S, Skourti-Stathaki K, DeConti DK, Abderazzaq FO, Banerjee P, Demers TM, Wang YE, Quackenbush J, Livingston DM. BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52. Nature. 2021 Mar; 591(7851):665-670. PMID: 33536619.
    Citations: 4     Fields:    
  3. Hatchi E, Livingston DM. Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient Human Tumor Cells. Cancer Cell. 2020 02 10; 37(2):139-140. PMID: 32049041.
    Citations:    Fields:    Translation:Humans
  4. Vohhodina J, Toomire KJ, Petit SA, Micevic G, Kumari G, Botchkarev VV, Li Z, Livingston DM, Hu Y. RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci. Proc Natl Acad Sci U S A. 2020 01 28; 117(4):2084-2091. PMID: 31932421.
    Citations: 2     Fields:    Translation:HumansCells
  5. Wang H, Xiang D, Liu B, He A, Randle HJ, Zhang KX, Dongre A, Sachs N, Clark AP, Tao L, Chen Q, Botchkarev VV, Xie Y, Dai N, Clevers H, Li Z, Livingston DM. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019 06 27; 178(1):135-151.e19. PMID: 31251913.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  6. Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG, Livingston DM. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation. Proc Natl Acad Sci U S A. 2018 10 09; 115(41):E9600-E9609. PMID: 30254159.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Pena G, Michalski C, Donnelly RJ, Qin Y, Sifri ZC, Mosenthal AC, Livingston DH, Spolarics Z. Trauma-Induced Acute X Chromosome Skewing in White Blood Cells Represents an Immuno-Modulatory Mechanism Unique to Females and a Likely Contributor to Sex-Based Outcome Differences. Shock. 2017 04; 47(4):402-408. PMID: 27749765.
    Citations: 4     Fields:    Translation:HumansCells
  8. Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM. Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage. Proc Natl Acad Sci U S A. 2016 11 29; 113(48):E7701-E7709. PMID: 27849576.
    Citations: 52     Fields:    Translation:HumansCells
  9. Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R. Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics. Clin Cancer Res. 2017 Mar 01; 23(5):1263-1273. PMID: 27573169.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  10. Wang H, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, Liu B, Gelman R, Giobbie-Hurder A, Feunteun J, Polyak K, Livingston DM. BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell. 2016 07 21; 63(2):277-292. PMID: 27373334.
    Citations: 19     Fields:    Translation:HumansCells
  11. Kozar RA, Arbabi S, Stein DM, Shackford SR, Barraco RD, Biffl WL, Brasel KJ, Cooper Z, Fakhry SM, Livingston D, Moore F, Luchette F. Injury in the aged: Geriatric trauma care at the crossroads. J Trauma Acute Care Surg. 2015 Jun; 78(6):1197-209. PMID: 26151523.
    Citations: 26     Fields:    Translation:Humans
  12. Brown M, Chinnaiyan A, Farsetti A, Livingston DM, Loda M, Schuele R, Mihich E. 26th Pezcoller symposium: cancers driven by hormones. Cancer Res. 2015 Apr 01; 75(7):1177-80. PMID: 25788695.
    Citations:    Fields:    Translation:HumansAnimals
  13. Hatchi E, Skourti-Stathaki K, Ventz S, Pinello L, Yen A, Kamieniarz-Gdula K, Dimitrov S, Pathania S, McKinney KM, Eaton ML, Kellis M, Hill SJ, Parmigiani G, Proudfoot NJ, Livingston DM. BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair. Mol Cell. 2015 Feb 19; 57(4):636-647. PMID: 25699710.
    Citations: 146     Fields:    Translation:HumansCells
  14. White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM. Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. J Virol. 2015 Mar; 89(5):2857-65. PMID: 25540383.
    Citations: 8     Fields:    Translation:HumansCells
  15. Baratta MG, Schinzel AC, Zwang Y, Bandopadhayay P, Bowman-Colin C, Kutt J, Curtis J, Piao H, Wong LC, Kung AL, Beroukhim R, Bradner JE, Drapkin R, Hahn WC, Liu JF, Livingston DM. An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma. Proc Natl Acad Sci U S A. 2015 Jan 06; 112(1):232-7. PMID: 25535366.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  16. Pathania S, Bade S, Le Guillou M, Burke K, Reed R, Bowman-Colin C, Su Y, Ting DT, Polyak K, Richardson AL, Feunteun J, Garber JE, Livingston DM. BRCA1 haploinsufficiency for replication stress suppression in primary cells. Nat Commun. 2014 Nov 17; 5:5496. PMID: 25400221.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  17. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov. 2014 Dec; 4(12):1430-47. PMID: 25252691.
    Citations: 47     Fields:    Translation:HumansCells
  18. Smith JA, Haberstroh FS, White EA, Livingston DM, DeCaprio JA, Howley PM. SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014 Nov; 468-470:311-321. PMID: 25222147.
    Citations: 12     Fields:    Translation:HumansCells
  19. Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 01; 28(17):1957-75. PMID: 25184681.
    Citations: 43     Fields:    Translation:HumansCells
  20. Hill SJ, Clark AP, Silver DP, Livingston DM. BRCA1 pathway function in basal-like breast cancer cells. Mol Cell Biol. 2014 Oct; 34(20):3828-42. PMID: 25092866.
    Citations: 24     Fields:    Translation:HumansCells
  21. Pores Fernando AT, Andrabi S, Cizmecioglu O, Zhu C, Livingston DM, Higgins JM, Schaffhausen BS, Roberts TM. Polyoma small T antigen triggers cell death via mitotic catastrophe. Oncogene. 2015 May 07; 34(19):2483-92. PMID: 24998850.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Naetar N, Soundarapandian V, Litovchick L, Goguen KL, Sablina AA, Bowman-Colin C, Sicinski P, Hahn WC, DeCaprio JA, Livingston DM. PP2A-mediated regulation of Ras signaling in G2 is essential for stable quiescence and normal G1 length. Mol Cell. 2014 Jun 19; 54(6):932-45. PMID: 24857551.
    Citations: 24     Fields:    Translation:HumansCells
  23. Dimitrov SD, Lu D, Naetar N, Hu Y, Pathania S, Kanellopoulou C, Livingston DM. Physiological modulation of endogenous BRCA1 p220 abundance suppresses DNA damage during the cell cycle. Genes Dev. 2013 Oct 15; 27(20):2274-91. PMID: 24142877.
    Citations: 13     Fields:    Translation:HumansCells
  24. Kaelin W, Livingston D, Loda M, Vousden K, Mihich E. Twenty-fifth annual Pezcoller Symposium: Metabolism and tumorigenesis. Cancer Res. 2013 Oct 15; 73(20):6124-7. PMID: 24097824.
    Citations:    Fields:    Translation:HumansAnimals
  25. Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, Livingston DM. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8632-7. PMID: 23657012.
    Citations: 26     Fields:    Translation:HumansAnimals
  26. Marais R, Sellers W, Livingston D, Mihich E. Twenty-fourth annual Pezcoller symposium: Molecular basis for resistance to targeted agents. Cancer Res. 2013 Feb 01; 73(3):1046-9. PMID: 23222297.
    Citations: 2     Fields:    Translation:Humans
  27. Kwiatt ME, Patel MS, Ross SE, Lachant MT, MacNew HG, Ochsner MG, Norwood SH, Speier L, Kozar R, Gerber JA, Rowell S, Krishnakumar S, Livingston DH, Manis G, Haan JM. Is low-molecular-weight heparin safe for venous thromboembolism prophylaxis in patients with traumatic brain injury? A Western Trauma Association multicenter study. J Trauma Acute Care Surg. 2012 Sep; 73(3):625-8. PMID: 22929493.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  28. Jirawatnotai S, Hu Y, Livingston DM, Sicinski P. Proteomic identification of a direct role for cyclin d1 in DNA damage repair. Cancer Res. 2012 Sep 01; 72(17):4289-93. PMID: 22915759.
    Citations: 28     Fields:    Translation:HumansCells
  29. Silver DP, Livingston DM. Mechanisms of BRCA1 tumor suppression. Cancer Discov. 2012 Aug; 2(8):679-84. PMID: 22843421.
    Citations: 51     Fields:    Translation:HumansAnimals
  30. Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012 Aug 10; 47(3):396-409. PMID: 22704558.
    Citations: 135     Fields:    Translation:HumansCells
  31. Homnick A, Sifri Z, Yonclas P, Mohr A, Livingston D. The temporal course of intracranial haemorrhage progression: how long is observation necessary? Injury. 2012 Dec; 43(12):2122-5. PMID: 22658418.
    Citations: 10     Fields:    Translation:Humans
  32. Friedl P, Hubbell J, Livingston D, Mihich E. Twenty-third annual Pezcoller Symposium: engineering influences in cancer research. Cancer Res. 2012 Feb 15; 72(4):841-4. PMID: 22237623.
    Citations:    Fields:    Translation:HumansAnimalsCells
  33. Pathania S, Nguyen J, Hill SJ, Scully R, Adelmant GO, Marto JA, Feunteun J, Livingston DM. BRCA1 is required for postreplication repair after UV-induced DNA damage. Mol Cell. 2011 Oct 21; 44(2):235-51. PMID: 21963239.
    Citations: 57     Fields:    Translation:HumansCells
  34. Jirawatnotai S, Hu Y, Michowski W, Elias JE, Becks L, Bienvenu F, Zagozdzon A, Goswami T, Wang YE, Clark AB, Kunkel TA, van Harn T, Xia B, Correll M, Quackenbush J, Livingston DM, Gygi SP, Sicinski P. A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature. 2011 Jun 08; 474(7350):230-4. PMID: 21654808.
    Citations: 148     Fields:    Translation:HumansAnimalsCells
  35. Zimmer SN, Zhou Q, Zhou T, Cheng Z, Abboud-Werner SL, Horn D, Lecocke M, White R, Krivtsov AV, Armstrong SA, Kung AL, Livingston DM, Rebel VI. Crebbp haploinsufficiency in mice alters the bone marrow microenvironment, leading to loss of stem cells and excessive myelopoiesis. Blood. 2011 Jul 07; 118(1):69-79. PMID: 21555743.
    Citations: 16     Fields:    Translation:AnimalsCells
  36. Hu Y, Scully R, Sobhian B, Xie A, Shestakova E, Livingston DM. RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci. Genes Dev. 2011 Apr 01; 25(7):685-700. PMID: 21406551.
    Citations: 116     Fields:    Translation:HumansCells
  37. Rio Frio T, Bahubeshi A, Kanellopoulou C, Hamel N, Niedziela M, Sabbaghian N, Pouchet C, Gilbert L, O'Brien PK, Serfas K, Broderick P, Houlston RS, Lesueur F, Bonora E, Muljo S, Schimke RN, Bouron-Dal Soglio D, Arseneau J, Schultz KA, Priest JR, Nguyen VH, Harach HR, Livingston DM, Foulkes WD, Tischkowitz M. DICER1 mutations in familial multinodular goiter with and without ovarian Sertoli-Leydig cell tumors. JAMA. 2011 Jan 05; 305(1):68-77. PMID: 21205968.
    Citations: 73     Fields:    Translation:Humans