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Samuel Edward Lux IV, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL081608 (LUX, SAMUEL E) Jul 1, 2005 - Jun 30, 2010
    NIH/NHLBI
    Spectrin-Actin Junctions of the Erythrocyte Skeleton
    Role: Principal Investigator
  2. P01HL032262 (ORKIN, STUART H) Jul 1, 1997 - Mar 31, 2022
    NIH/NHLBI
    DEVELOPMENTAL BIOLOGY OF HUMAN ERYTHROPOIESIS
    Role: Co-Principal Investigator
  3. K12DK001977 (LUX, SAMUEL E) Jul 1, 1990 - Jun 30, 1999
    NIH/NIDDK
    PROGRAM PHYSICAL SCIENTIST AWARD
    Role: Principal Investigator
  4. R01DK034083 (LUX, SAMUEL E) Jul 1, 1983 - Jun 30, 2006
    NIH/NIDDK
    PATHOPHYSIOLOGY OF RED CELL MEMBRANE DISEASE
    Role: Principal Investigator
  5. R37DK034083 (LUX, SAMUEL E) Jul 1, 1983 - Jun 30, 1996
    NIH/NIDDK
    PATHOPHYSIOLOGY OF RED CELL MEMBRANE DISEASE
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gross C, O'Halloran C, Winn AS, Lux SE, Michelson CD, Sectish T, Sox CM. Application Factors Associated With Clinical Performance During Pediatric Internship. Acad Pediatr. 2020 Apr 05. PMID: 32268217.
    Citations:    
  2. Lacy JN, Ulirsch JC, Grace RF, Towne MC, Hale J, Mohandas N, Lux SE, Agrawal PB, Sankaran VG. Exome sequencing results in successful diagnosis and treatment of a severe congenital anemia. Cold Spring Harb Mol Case Stud. 2016 Jul; 2(4):a000885. PMID: 27551681.
    Citations: 2     Fields:    
  3. Lux SE. Anatomy of the red cell membrane skeleton: unanswered questions. Blood. 2016 Jan 14; 127(2):187-99. PMID: 26537302.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  4. Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Heneghan JF, Li X, Hsu A, Karpatkin M, O'Neill AF, Bauer DE, Heeney MM, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL. Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol. 2011 Dec; 301(6):C1325-43. PMID: 21849667.
    Citations: 4     Fields:    Translation:HumansCells
  5. Williams DA, Porter ES, Lux SE, Grier HE, Mack JW, Orkin SH. Training program in cancer and blood diseases: Pediatric Hematology/Oncology Fellowship Program, Children's Hospital Boston/Dana-Farber Cancer Institute. Am J Hematol. 2010 Oct; 85(10):793-4. PMID: 20730793.
    Citations: 1     Fields:    Translation:Humans
  6. Korsgren C, Lux SE. The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding. Blood. 2010 Oct 07; 116(14):2600-7. PMID: 20585040.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  7. Stankewich MC, Gwynn B, Ardito T, Ji L, Kim J, Robledo RF, Lux SE, Peters LL, Morrow JS. Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. Proc Natl Acad Sci U S A. 2010 Mar 30; 107(13):6022-7. PMID: 20231455.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  8. Robledo RF, Lambert AJ, Birkenmeier CS, Cirlan MV, Cirlan AF, Campagna DR, Lux SE, Peters LL. Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in alpha-spectrin-deficient red cells. Blood. 2010 Mar 04; 115(9):1804-14. PMID: 20056793.
    Citations: 4     Fields:    Translation:AnimalsCells
  9. Korsgren C, Peters LL, Lux SE. Protein 4.2 binds to the carboxyl-terminal EF-hands of erythroid alpha-spectrin in a calcium- and calmodulin-dependent manner. J Biol Chem. 2010 Feb 12; 285(7):4757-70. PMID: 20007969.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Stapleton FB, Lux SE. A uniform third-year application and offer date for pediatric fellow applicants: pro and con. J Pediatr. 2006 Nov; 149(5):587-588. PMID: 17095320.
    Citations: 1     Fields:    Translation:Humans
  11. An X, Debnath G, Guo X, Liu S, Lux SE, Baines A, Gratzer W, Mohandas N. Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate. Biochemistry. 2005 Aug 09; 44(31):10681-8. PMID: 16060676.
    Citations: 24     Fields:    Translation:HumansCells
  12. Eber S, Lux SE. Hereditary spherocytosis--defects in proteins that connect the membrane skeleton to the lipid bilayer. Semin Hematol. 2004 Apr; 41(2):118-41. PMID: 15071790.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  13. Lux S, Marshall JC, Ritzl A, Weiss PH, Pietrzyk U, Shah NJ, Zilles K, Fink GR. A functional magnetic resonance imaging study of local/global processing with stimulus presentation in the peripheral visual hemifields. Neuroscience. 2004; 124(1):113-20. PMID: 14960344.
    Citations: 21     Fields:    Translation:Humans
  14. Peters LL, Swearingen RA, Andersen SG, Gwynn B, Lambert AJ, Li R, Lux SE, Churchill GA. Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency. Blood. 2004 Apr 15; 103(8):3233-40. PMID: 15070709.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  15. Ozcan R, Jarolim P, Lux SE, Ungewickell E, Eber SW. Simultaneous (AC)n microsatellite polymorphism analysis and single-stranded conformation polymorphism screening is an efficient strategy for detecting ankyrin-1 mutations in dominant hereditary spherocytosis. Br J Haematol. 2003 Aug; 122(4):669-77. PMID: 12899723.
    Citations: 2     Fields:    Translation:HumansCells
  16. Paw BH, Davidson AJ, Zhou Y, Li R, Pratt SJ, Lee C, Trede NS, Brownlie A, Donovan A, Liao EC, Ziai JM, Drejer AH, Guo W, Kim CH, Gwynn B, Peters LL, Chernova MN, Alper SL, Zapata A, Wickramasinghe SN, Lee MJ, Lux SE, Fritz A, Postlethwait JH, Zon LI. Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency. Nat Genet. 2003 May; 34(1):59-64. PMID: 12669066.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  17. Tse WT, Tang J, Jin O, Korsgren C, John KM, Kung AL, Gwynn B, Peters LL, Lux SE. A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix. J Biol Chem. 2001 Jun 29; 276(26):23974-85. PMID: 11294830.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  18. Gallagher PG, Romana M, Tse WT, Lux SE, Forget BG. The human ankyrin-1 gene is selectively transcribed in erythroid cell lines despite the presence of a housekeeping-like promoter. Blood. 2000 Aug 01; 96(3):1136-43. PMID: 10910934.
    Citations: 21     Fields:    Translation:HumansCells
  19. Donovan A, Brownlie A, Zhou Y, Shepard J, Pratt SJ, Moynihan J, Paw BH, Drejer A, Barut B, Zapata A, Law TC, Brugnara C, Lux SE, Pinkus GS, Pinkus JL, Kingsley PD, Palis J, Fleming MD, Andrews NC, Zon LI. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000 Feb 17; 403(6771):776-81. PMID: 10693807.
    Citations: 335     Fields:    Translation:HumansAnimalsCells
  20. Jensen LJ, Stuart-Tilley AK, Peters LL, Lux SE, Alper SL, Breton S. Immunolocalization of AE2 anion exchanger in rat and mouse epididymis. Biol Reprod. 1999 Oct; 61(4):973-80. PMID: 10491632.
    Citations: 12     Fields:    Translation:Animals
  21. Rasband MN, Peles E, Trimmer JS, Levinson SR, Lux SE, Shrager P. Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS. J Neurosci. 1999 Sep 01; 19(17):7516-28. PMID: 10460258.
    Citations: 114     Fields:    Translation:AnimalsCells
  22. Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res. 1999 Jun 08; 69(2):273-80. PMID: 10366748.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  23. Peters LL, Jindel HK, Gwynn B, Korsgren C, John KM, Lux SE, Mohandas N, Cohen CM, Cho MR, Golan DE, Brugnara C. Mild spherocytosis and altered red cell ion transport in protein 4. 2-null mice. J Clin Invest. 1999 Jun; 103(11):1527-37. PMID: 10359562.
    Citations: 30     Fields:    Translation:AnimalsCells
  24. Berezovska O, McLean P, Knowles R, Frosh M, Lu FM, Lux SE, Hyman BT. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience. 1999; 93(2):433-9. PMID: 10465425.
    Citations: 53     Fields:    Translation:AnimalsCells
  25. Tse WT, Lux SE. Red blood cell membrane disorders. Br J Haematol. 1999 Jan; 104(1):2-13. PMID: 10027705.
    Citations: 33     Fields:    Translation:HumansCells
  26. Cho MR, Eber SW, Liu SC, Lux SE, Golan DE. Regulation of band 3 rotational mobility by ankyrin in intact human red cells. Biochemistry. 1998 Dec 22; 37(51):17828-35. PMID: 9922149.
    Citations: 9     Fields:    Translation:HumansCells
  27. Stankewich MC, Tse WT, Peters LL, Ch'ng Y, John KM, Stabach PR, Devarajan P, Morrow JS, Lux SE. A widely expressed betaIII spectrin associated with Golgi and cytoplasmic vesicles. Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14158-63. PMID: 9826670.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  28. Doctor RB, Chen J, Peters LL, Lux SE, Mandel LJ. Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules. Am J Physiol. 1998 01; 274(1):F129-38. PMID: 9458832.
    Citations: 17     Fields:    Translation:AnimalsCells
  29. Gallagher PG, Tse WT, Scarpa AL, Lux SE, Forget BG. Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing. J Biol Chem. 1997 Aug 01; 272(31):19220-8. PMID: 9235914.
    Citations: 18     Fields:    Translation:HumansCells
  30. Hoock TC, Peters LL, Lux SE. Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. J Cell Biol. 1997 Mar 10; 136(5):1059-70. PMID: 9060470.
    Citations: 22     Fields:    Translation:AnimalsCells
  31. Peters LL, Shivdasani RA, Liu SC, Hanspal M, John KM, Gonzalez JM, Brugnara C, Gwynn B, Mohandas N, Alper SL, Orkin SH, Lux SE. Anion exchanger 1 (band 3) is required to prevent erythrocyte membrane surface loss but not to form the membrane skeleton. Cell. 1996 Sep 20; 86(6):917-27. PMID: 8808627.
    Citations: 57     Fields:    Translation:AnimalsCells
  32. Shalev O, Shinar E, Lux SE. Isolated beta-globin chains reproduce, in normal red cell membranes, the defective binding of spectrin to alpha-thalassaemic membranes. Br J Haematol. 1996 Aug; 94(2):273-8. PMID: 8759886.
    Citations:    Fields:    Translation:HumansCells
  33. Eber SW, Gonzalez JM, Lux ML, Scarpa AL, Tse WT, Dornwell M, Herbers J, Kugler W, Ozcan R, Pekrun A, Gallagher PG, Schröter W, Forget BG, Lux SE. Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis. Nat Genet. 1996 Jun; 13(2):214-8. PMID: 8640229.
    Citations: 39     Fields:    Translation:HumansCells
  34. Lu FM, Lux SE. Constitutively active human Notch1 binds to the transcription factor CBF1 and stimulates transcription through a promoter containing a CBF1-responsive element. Proc Natl Acad Sci U S A. 1996 May 28; 93(11):5663-7. PMID: 8643633.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  35. Jenkins PB, Abou-Alfa GK, Dhermy D, Bursaux E, Féo C, Scarpa AL, Lux SE, Garbarz M, Forget BG, Gallagher PG. A nonsense mutation in the erythrocyte band 3 gene associated with decreased mRNA accumulation in a kindred with dominant hereditary spherocytosis. J Clin Invest. 1996 Jan 15; 97(2):373-80. PMID: 8567957.
    Citations: 4     Fields:    Translation:HumansCells
  36. Joiner CH, Franco RS, Jiang M, Franco MS, Barker JE, Lux SE. Increased cation permeability in mutant mouse red blood cells with defective membrane skeletons. Blood. 1995 Dec 01; 86(11):4307-14. PMID: 7492791.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  37. Piepenhagen PA, Peters LL, Lux SE, Nelson WJ. Differential expression of Na(+)-K(+)-ATPase, ankyrin, fodrin, and E-cadherin along the kidney nephron. Am J Physiol. 1995 Dec; 269(6 Pt 1):C1417-32. PMID: 8572171.
    Citations: 14     Fields:    Translation:Animals
  38. Morris MB, Lux SE. Characterization of the binary interaction between human erythrocyte protein 4.1 and actin. Eur J Biochem. 1995 Aug 01; 231(3):644-50. PMID: 7649164.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  39. Peters LL, John KM, Lu FM, Eicher EM, Higgins A, Yialamas M, Turtzo LC, Otsuka AJ, Lux SE. Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain. J Cell Biol. 1995 Jul; 130(2):313-30. PMID: 7615634.
    Citations: 37     Fields:    Translation:AnimalsCells
  40. White RA, Geissler EN, Adkison LR, Dowler LL, Alper SL, Lux SE. Chromosomal location of the murine anion exchanger genes encoding AE2 and AE3. Mamm Genome. 1994 Dec; 5(12):827-9. PMID: 7894173.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  41. Platt OS, Lux SE, Falcone JF. A highly conserved region of human erythrocyte ankyrin contains the capacity to bind spectrin. J Biol Chem. 1993 Nov 15; 268(32):24421-6. PMID: 8226993.
    Citations: 12     Fields:    Translation:HumansCells
  42. Savvides P, Shalev O, John KM, Lux SE. Combined spectrin and ankyrin deficiency is common in autosomal dominant hereditary spherocytosis. Blood. 1993 Nov 15; 82(10):2953-60. PMID: 8219186.
    Citations: 12     Fields:    Translation:HumansCells
  43. Becker PS, Tse WT, Lux SE, Forget BG. Beta spectrin kissimmee: a spectrin variant associated with autosomal dominant hereditary spherocytosis and defective binding to protein 4.1. J Clin Invest. 1993 Aug; 92(2):612-6. PMID: 8102379.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  44. Birkenmeier CS, White RA, Peters LL, Hall EJ, Lux SE, Barker JE. Complex patterns of sequence variation and multiple 5' and 3' ends are found among transcripts of the erythroid ankyrin gene. J Biol Chem. 1993 May 05; 268(13):9533-40. PMID: 8486643.
    Citations: 20     Fields:    Translation:AnimalsCells
  45. Peters LL, Andrews NC, Eicher EM, Davidson MB, Orkin SH, Lux SE. Mouse microcytic anaemia caused by a defect in the gene encoding the globin enhancer-binding protein NF-E2. Nature. 1993 Apr 22; 362(6422):768-70. PMID: 8469289.
    Citations: 19     Fields:    Translation:AnimalsCells
  46. Peters LL, Lux SE. Ankyrins: structure and function in normal cells and hereditary spherocytes. Semin Hematol. 1993 Apr; 30(2):85-118. PMID: 8480190.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  47. White RA, Peters LL, Adkison LR, Korsgren C, Cohen CM, Lux SE. The murine pallid mutation is a platelet storage pool disease associated with the protein 4.2 (pallidin) gene. Nat Genet. 1992 Sep; 2(1):80-3. PMID: 1284644.
    Citations: 18     Fields:    Translation:HumansAnimals
  48. Wang CC, Badylak JA, Lux SE, Moriyama R, Dixon JE, Low PS. Expression, purification, and characterization of the functional dimeric cytoplasmic domain of human erythrocyte band 3 in Escherichia coli. Protein Sci. 1992 Sep; 1(9):1206-14. PMID: 1304397.
    Citations: 10     Fields:    Translation:HumansCells
  49. Peters LL, White RA, Birkenmeier CS, Bloom ML, Lux SE, Barker JE. Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo. Proc Natl Acad Sci U S A. 1992 Jul 01; 89(13):5749-53. PMID: 1385865.
    Citations: 10     Fields:    Translation:AnimalsCells
  50. Gallagher PG, Tse WT, Scarpa AL, Lux SE, Forget BG. Large numbers of alternatively spliced isoforms of the regulatory region of human erythrocyte ankyrin. Trans Assoc Am Physicians. 1992; 105:268-77. PMID: 1309004.
    Citations: 5     Fields:    Translation:HumansCells
  51. White RA, Birkenmeier CS, Peters LL, Barker JE, Lux SE. Murine erythrocyte ankyrin cDNA: highly conserved regions of the regulatory domain. Mamm Genome. 1992; 3(5):281-5. PMID: 1386265.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  52. Peters LL, Birkenmeier CS, Bronson RT, White RA, Lux SE, Otto E, Bennett V, Higgins A, Barker JE. Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. J Cell Biol. 1991 Sep; 114(6):1233-41. PMID: 1716634.
    Citations: 25     Fields:    Translation:AnimalsCells
  53. Tse WT, Menninger JC, Yang-Feng TL, Francke U, Sahr KE, Lux SE, Ward DC, Forget BG. Isolation and chromosomal localization of a novel nonerythroid ankyrin gene. Genomics. 1991 Aug; 10(4):858-66. PMID: 1833308.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  54. Becker PS, Schwartz MA, Morrow JS, Lux SE. Radiolabel-transfer cross-linking demonstrates that protein 4.1 binds to the N-terminal region of beta spectrin and to actin in binary interactions. Eur J Biochem. 1990 Nov 13; 193(3):827-36. PMID: 2249696.
    Citations: 10     Fields:    Translation:HumansCells
  55. Costa FF, Agre P, Watkins PC, Winkelmann JC, Tang TK, John KM, Lux SE, Forget BG. Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin. N Engl J Med. 1990 Oct 11; 323(15):1046-50. PMID: 1977081.
    Citations: 18     Fields:    Translation:HumansCells
  56. Lux SE, Tse WT, Menninger JC, John KM, Harris P, Shalev O, Chilcote RR, Marchesi SL, Watkins PC, Bennett V, et al. Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. Nature. 1990 Jun 21; 345(6277):736-9. PMID: 2141669.
    Citations: 52     Fields:    Translation:HumansCells
  57. White RA, Birkenmeier CS, Lux SE, Barker JE. Ankyrin and the hemolytic anemia mutation, nb, map to mouse chromosome 8: presence of the nb allele is associated with a truncated erythrocyte ankyrin. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3117-21. PMID: 2139228.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  58. Lux SE, John KM, Bennett V. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. Nature. 1990 Mar 01; 344(6261):36-42. PMID: 2137557.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  59. Tse WT, Menninger JC, Ward DC, Chilcote RR, John KM, Lux SE, Forget BG. Demonstration of the deletion of a copy of the ankyrin gene in a patient with hereditary spherocytosis by in situ hybridization. Trans Assoc Am Physicians. 1990; 103:242-8. PMID: 2151901.
    Citations:    Fields:    Translation:HumansCells
  60. Lux SE, John KM, Kopito RR, Lodish HF. Cloning and characterization of band 3, the human erythrocyte anion-exchange protein (AE1). Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9089-93. PMID: 2594752.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  61. Davies KA, Lux SE. Hereditary disorders of the red cell membrane skeleton. Trends Genet. 1989 Jul; 5(7):222-7. PMID: 2675425.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  62. Davis L, Lux SE, Bennett V. Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. J Biol Chem. 1989 Jun 05; 264(16):9665-72. PMID: 2470759.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  63. Shinar E, Rachmilewitz EA, Lux SE. Differing erythrocyte membrane skeletal protein defects in alpha and beta thalassemia. J Clin Invest. 1989 Feb; 83(2):404-10. PMID: 2521488.
    Citations: 14     Fields:    Translation:HumansCells
  64. Moo-Penn WF, Jue DL, Johnson MH, Olsen KW, Shih D, Jones RT, Lux SE, Rodgers P, Arnone A. Hemoglobin Brockton [beta 138 (H16) Ala----Pro]: an unstable variant near the C-terminus of the beta-subunits with normal oxygen-binding properties. Biochemistry. 1988 Oct 04; 27(20):7614-9. PMID: 3207692.
    Citations: 1     Fields:    Translation:HumansCells
  65. Becker PS, Morrow JS, Lux SE. Abnormal oxidant sensitivity and beta-chain structure of spectrin in hereditary spherocytosis associated with defective spectrin-protein 4.1 binding. J Clin Invest. 1987 Aug; 80(2):557-65. PMID: 3611357.
    Citations: 8     Fields:    Translation:HumansCells
  66. Joiner CH, Platt OS, Lux SE. Cation depletion by the sodium pump in red cells with pathologic cation leaks. Sickle cells and xerocytes. J Clin Invest. 1986 Dec; 78(6):1487-96. PMID: 2430999.
    Citations: 5     Fields:    Translation:HumansCells
  67. Wolfe LC, Byrne AM, Lux SE. Molecular defect in the membrane skeleton of blood bank-stored red cells. Abnormal spectrin-protein 4.1-actin complex formation. J Clin Invest. 1986 Dec; 78(6):1681-6. PMID: 3782475.
    Citations: 14     Fields:    Translation:HumansCells
  68. Becker PS, Cohen CM, Lux SE. The effect of mild diamide oxidation on the structure and function of human erythrocyte spectrin. J Biol Chem. 1986 Apr 05; 261(10):4620-8. PMID: 3957910.
    Citations: 20     Fields:    Translation:HumansCells
  69. Beaven GH, Jean-Baptiste L, Ungewickell E, Baines AJ, Shahbakhti F, Pinder JC, Lux SE, Gratzer WB. An examination of the soluble oligomeric complexes extracted from the red cell membrane and their relation to the membrane cytoskeleton. Eur J Cell Biol. 1985 Mar; 36(2):299-306. PMID: 4039666.
    Citations: 9     Fields:    Translation:HumansCells
  70. Becker PS, Lux SE. Hereditary spherocytosis and related disorders. Clin Haematol. 1985 Feb; 14(1):15-43. PMID: 3886234.
    Citations: 13     Fields:    Translation:HumansCells
  71. Platt OS, Falcone JF, Lux SE. Molecular defect in the sickle erythrocyte skeleton. Abnormal spectrin binding to sickle inside-our vesicles. J Clin Invest. 1985 Jan; 75(1):266-71. PMID: 2578138.
    Citations: 10     Fields:    Translation:HumansCells
  72. Becker PS, Lux SE. The effect of oxidation on the structure and function of human erythrocyte spectrin. Prog Clin Biol Res. 1985; 195:185-93. PMID: 4059268.
    Citations:    Fields:    Translation:HumansCells
  73. Beardsley DS, Spiegel JE, Jacobs MM, Handin RI, Lux SE. Platelet membrane glycoprotein IIIa contains target antigens that bind anti-platelet antibodies in immune thrombocytopenias. J Clin Invest. 1984 Nov; 74(5):1701-7. PMID: 6238978.
    Citations: 24     Fields:    Translation:HumansCells
  74. Shohet SB, Lux SE. The erythrocyte membrane skeleton: pathophysiology. Hosp Pract (Off Ed). 1984 Nov; 19(11):89-95, 99, 103 passim. PMID: 6436279.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  75. Lux S, Shohet SB. The erythrocyte membrane skeleton: biochemistry. Hosp Pract (Off Ed). 1984 Oct; 19(10):77-83. PMID: 6434565.
    Citations: 1     Fields:    Translation:HumansCells
  76. Ohanian V, Wolfe LC, John KM, Pinder JC, Lux SE, Gratzer WB. Analysis of the ternary interaction of the red cell membrane skeletal proteins spectrin, actin, and 4.1. Biochemistry. 1984 Sep 11; 23(19):4416-20. PMID: 6487610.
    Citations: 33     Fields:    Translation:HumansCells
  77. Spiegel JE, Beardsley DS, Southwick FS, Lux SE. An analogue of the erythroid membrane skeletal protein 4.1 in nonerythroid cells. J Cell Biol. 1984 Sep; 99(3):886-93. PMID: 6206079.
    Citations: 21     Fields:    Translation:HumansCells
  78. Pinder JC, Dhermy D, Baines AJ, Lux SE, Gratzer WB. A phenomenological difference between membrane skeletal protein complexes isolated from normal and hereditary spherocytosis erythrocytes. Br J Haematol. 1983 Nov; 55(3):455-63. PMID: 6639887.
    Citations: 1     Fields:    Translation:HumansCells
  79. Becker PS, Spiegel JE, Wolfe LC, Lux SE. High yield purification of protein 4.1 from human erythrocyte membranes. Anal Biochem. 1983 Jul 01; 132(1):195-201. PMID: 6625159.
    Citations: 7     Fields:    Translation:HumansCells
  80. Palek J, Lux SE. Red cell membrane skeletal defects in hereditary and acquired hemolytic anemias. Semin Hematol. 1983 Jul; 20(3):189-224. PMID: 6353590.
    Citations: 38     Fields:    Translation:HumansCells
  81. Unger AE, Harris MJ, Bernstein SE, Falcone JC, Lux SE. Hemolytic anemia in the mouse. Report of a new mutation and clarification of its genetics. J Hered. 1983 Mar-Apr; 74(2):88-92. PMID: 6841965.
    Citations: 3     Fields:    Translation:Animals
  82. Wolfe LC, John KM, Falcone JC, Byrne AM, Lux SE. A genetic defect in the binding of protein 4.1 to spectrin in a kindred with hereditary spherocytosis. N Engl J Med. 1982 Nov 25; 307(22):1367-74. PMID: 6215583.
    Citations: 23     Fields:    Translation:HumansCells
  83. Mohandas N, Clark MR, Health BP, Rossi M, Wolfe LC, Lux SE, Shohet SB. A technique to detect reduced mechanical stability of red cell membranes: relevance to elliptocytic disorders. Blood. 1982 Apr; 59(4):768-74. PMID: 7059678.
    Citations: 36     Fields:    Translation:Cells
  84. Platt OS, Lux SE, Nathan DG. Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity. J Clin Invest. 1981 Sep; 68(3):631-8. PMID: 7276163.
    Citations: 9     Fields:    Translation:HumansCells
  85. Tomaselli MB, John KM, Lux SE. Elliptical erythrocyte membrane skeletons and heat-sensitive spectrin in hereditary elliptocytosis. Proc Natl Acad Sci U S A. 1981 Mar; 78(3):1911-5. PMID: 6940197.
    Citations: 11     Fields:    Translation:HumansCells
  86. Lux SE, Wolfe LC, Pease B, Tomaselli MB, John KM, Bernstein SE. Hemolytic anemias due to abnormalities in red cell spectrin: a brief review. Prog Clin Biol Res. 1981; 45:159-68. PMID: 7017750.
    Citations:    Fields:    Translation:HumansAnimalsCells
  87. Harris HW, Lux SE. Structural characterization of the phosphorylation sites of human erythrocyte spectrin. J Biol Chem. 1980 Dec 10; 255(23):11512-20. PMID: 7440554.
    Citations: 16     Fields:    Translation:HumansCells
  88. Harris HW, Levin N, Lux SE. Comparison of the phosphorylation of human erythrocyte spectrin in the intact red cell and in various cell-free systems. J Biol Chem. 1980 Dec 10; 255(23):11521-5. PMID: 7440555.
    Citations: 4     Fields:    Translation:HumansCells
  89. Lux SE, Wolfe LC. Inherited disorders of the red cell membrane skeleton. Pediatr Clin North Am. 1980 May; 27(2):463-86. PMID: 6992078.
    Citations: 5     Fields:    Translation:HumansCells
  90. Lux SE. Dissecting the red cell membrane skeleton. Nature. 1979 Oct 11; 281(5731):426-9. PMID: 573863.
    Citations: 46     Fields:    Translation:AnimalsCells
  91. Lux SE. Spectrin-actin membrane skeleton of normal and abnormal red blood cells. Semin Hematol. 1979 Jan; 16(1):21-51. PMID: 370983.
    Citations: 70     Fields:    Translation:HumansCells
  92. Lux SE, Pease B, Tomaselli MB, John KM, Bernstein SE. Hemolytic anemias associated with deficient or dysfunctional spectrin. Prog Clin Biol Res. 1979; 30:463-9. PMID: 531037.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  93. Glader BE, Lux SE, Muller-Soyano A, Platt OS, Propper RD, Nathan DG. Energy reserve and cation composition of irreversibly sickled cells in vivo. Br J Haematol. 1978 Dec; 40(4):527-32. PMID: 728369.
    Citations: 7     Fields:    Translation:HumansCells
  94. Wolfe LC, Lux SE. Membrane protein phosphorylation of intact normal and hereditary spherocytic erythrocytes. J Biol Chem. 1978 May 10; 253(9):3336-42. PMID: 205547.
    Citations: 14     Fields:    Translation:HumansCells
  95. Lux SE, John KM, Ukena TE. Diminished spectrin extraction from ATP-depleted human erythrocytes. Evidence relating spectrin to changes in erythrocyte shape and deformability. J Clin Invest. 1978 Mar; 61(3):815-27. PMID: 25286.
    Citations: 13     Fields:    Translation:HumansCells
  96. Lux SE, John KM. Isolation and partial characterization of a high molecular weight red cell membrane protein complex normally removed by the spleen. Blood. 1977 Oct; 50(4):625-41. PMID: 198046.
    Citations: 6     Fields:    Translation:HumansCells
  97. Lux SE, John KM. Evidence that spectrin is a determinant of shape and deformability in the human erythrocyte. Prog Clin Biol Res. 1977; 17:481-91. PMID: 928462.
    Citations:    Fields:    Translation:HumansCells
  98. Lux SE, John KM, Karnovsky MJ. Irreversible deformation of the spectrin-actin lattice in irreversibly sickled cells. J Clin Invest. 1976 Oct; 58(4):955-63. PMID: 965498.
    Citations: 41     Fields:    Translation:Cells
  99. Jackson RL, Gotto AM, Lux SE, John KM, Fleischer S. Human plasma high density lipoprotein. Interaction of the cyanogen bromide fragments from apolipoprotein glutamine II (A-II) with phosphatidylcholine. J Biol Chem. 1973 Dec 25; 248(24):8449-56. PMID: 4357738.
    Citations: 6     Fields:    Translation:AnimalsCells
  100. Lux SE, John KM, Brewer HB. Isolation and characterization of apoLp-Gln-II (apoA-II), a plasma high density apolipoprotein containing two identical polypeptide chains. J Biol Chem. 1972 Dec 10; 247(23):7510-8. PMID: 4344224.
    Citations: 23     Fields:    Translation:HumansCells
  101. Lux SE, John KM, Ronan R, Brewer HB. Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein. J Biol Chem. 1972 Dec 10; 247(23):7519-27. PMID: 4344225.
    Citations: 10     Fields:    Translation:HumansCells
  102. Lux SE, John KM, Fleischer S, Jackson RL, Gotto AM. Identification of the lipid-binding cyanogen bromide fragment from the cystine-containing high density apolipoprotein, APOLP-GLN-II. Biochem Biophys Res Commun. 1972 Oct 06; 49(1):23-9. PMID: 4342724.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  103. Lux SE, Levy RI, Gotto AM, Fredrickson DS. Studies on the protein defect in Tangier disease. Isolation and characterization of an abnormal high density lipoprotein. J Clin Invest. 1972 Oct; 51(10):2505-19. PMID: 4341435.
    Citations: 13     Fields:    Translation:Humans
  104. Lux SE, John KM. Further characterization of the polymorphic forms of a human high density apolipoprotein, apoLP-Gln-I (apoA-I). Biochim Biophys Acta. 1972 Sep 29; 278(2):266-70. PMID: 4343564.
    Citations: 1     Fields:    Translation:Humans
  105. Brewer HB, Lux SE, Ronan R, John KM. Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex. Proc Natl Acad Sci U S A. 1972 May; 69(5):1304-8. PMID: 4338591.
    Citations: 40     Fields:    Translation:HumansCells
  106. Jacob HS, Lux SE. Degradation of membrane phospholipids and thiols in peroxide hemolysis: studies in vitamin E deficiency. Blood. 1968 Oct; 32(4):549-68. PMID: 5687580.
    Citations: 18     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.