Harvard Catalyst Profiles

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Huiyan Zeng, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA191463 (ZENG, HUIYAN) Jul 7, 2015 - Jun 30, 2017
    Targeting orphan nuclear receptor TR3/Nur77 for tumor angiogenesis
    Role: Principal Investigator
  2. R03CA194795 (ZENG, HUIYAN) Apr 1, 2015 - Mar 31, 2017
    Down Syndrome Candidate Region 1 isoform 1L in tumor growth and metastasis
    Role: Principal Investigator
  3. R01CA133235 (ZENG, HUIYAN) Jul 7, 2009 - May 31, 2014
    Orphan Nuclear Receptor TR3 in tumor angiogenesis and associated microvessel perm
    Role: Principal Investigator
  4. K01CA098581 (ZENG, HUIYAN) Jul 22, 2003 - Jun 30, 2009
    Expression and Function of TR3/nur77 in angiogenesis
    Role: Principal Investigator
  5. F32CA086436 (ZENG, HUIYAN) Mar 15, 2000
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jung J, Zeng H, Horng T. Metabolism as a guiding force for immunity. Nat Cell Biol. 2019 01; 21(1):85-93. PMID: 30602764.
    Citations:    Fields:    
  2. Ye T, Peng J, Liu X, Hou S, Niu G, Li Y, Zeng H, Zhao D. Orphan nuclear receptor TR3/Nur77 differentially regulates the expression of integrins in angiogenesis. Microvasc Res. 2019 03; 122:22-33. PMID: 30391133.
    Citations:    Fields:    
  3. Jia J, Ye T, Cui P, Hua Q, Zeng H, Zhao D. AP-1 transcription factor mediates VEGF-induced endothelial cell migration and proliferation. Microvasc Res. 2016 May; 105:103-8. PMID: 26860974.
    Citations: 4     Fields:    Translation:HumansCells
  4. Zhou L, Cui P, Zhao S, Ye T, Li Y, Peng J, Niu G, Zhao D, Zeng H. Differential function and regulation of orphan nuclear receptor TR3 isoforms in endothelial cells. Tumour Biol. 2016 Mar; 37(3):3307-20. PMID: 26440050.
    Citations:    Fields:    Translation:HumansCells
  5. Li Y, Bourbon PM, Grant MA, Peng J, Ye T, Zhao D, Zeng H. Requirement of novel amino acid fragments of orphan nuclear receptor TR3/Nur77 for its functions in angiogenesis. Oncotarget. 2015 Sep 15; 6(27):24261-76. PMID: 26155943.
    Citations:    Fields:    Translation:HumansCells
  6. Chen X, Yang G, Song JH, Xu H, Li D, Goldsmith J, Zeng H, Parsons-Wingerter PA, Reinecker HC, Kelly CP. Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation. PLoS One. 2013; 8(5):e64227. PMID: 23675530.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  7. Qin L, Zhao D, Xu J, Ren X, Terwilliger EF, Parangi S, Lawler J, Dvorak HF, Zeng H. The vascular permeabilizing factors histamine and serotonin induce angiogenesis through TR3/Nur77 and subsequently truncate it through thrombospondin-1. Blood. 2013 Mar 14; 121(11):2154-64. PMID: 23315169.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  8. Zhao D, Qin L, Bourbon PM, James L, Dvorak HF, Zeng H. Orphan nuclear transcription factor TR3/Nur77 regulates microvessel permeability by targeting endothelial nitric oxide synthase and destabilizing endothelial junctions. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):12066-71. PMID: 21730126.
    Citations: 24     Fields:    Translation:AnimalsCells
  9. Zhao D, Bakirtzi K, Zhan Y, Zeng H, Koon HW, Pothoulakis C. Insulin-like growth factor-1 receptor transactivation modulates the inflammatory and proliferative responses of neurotensin in human colonic epithelial cells. J Biol Chem. 2011 Feb 25; 286(8):6092-9. PMID: 21212273.
    Citations: 22     Fields:    Translation:HumansCells
  10. Liu X, Zhao D, James L, Li J, Zeng H. Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor. FASEB J. 2011 Apr; 25(4):1188-97. PMID: 21169383.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  11. Zhao D, Desai S, Zeng H. VEGF stimulates PKD-mediated CREB-dependent orphan nuclear receptor Nurr1 expression: role in VEGF-induced angiogenesis. Int J Cancer. 2011 Jun 01; 128(11):2602-12. PMID: 20715116.
    Citations: 18     Fields:    Translation:HumansCells
  12. Liu X, Zhao D, Qin L, Li J, Zeng H. Transcription enhancer factor 3 (TEF3) mediates the expression of Down syndrome candidate region 1 isoform 1 (DSCR1-1L) in endothelial cells. J Biol Chem. 2008 Dec 05; 283(49):34159-67. PMID: 18840614.
    Citations: 4     Fields:    Translation:HumansCells
  13. Nagy JA, Benjamin L, Zeng H, Dvorak AM, Dvorak HF. Vascular permeability, vascular hyperpermeability and angiogenesis. Angiogenesis. 2008; 11(2):109-19. PMID: 18293091.
    Citations: 154     Fields:    Translation:HumansAnimals
  14. Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C. Neurotensin stimulates expression of early growth response gene-1 and EGF receptor through MAP kinase activation in human colonic epithelial cells. Int J Cancer. 2007 Apr 15; 120(8):1652-6. PMID: 17230532.
    Citations: 16     Fields:    Translation:HumansCells
  15. Qin L, Zhao D, Liu X, Nagy JA, Hoang MV, Brown LF, Dvorak HF, Zeng H. Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway. Mol Cancer Res. 2006 Nov; 4(11):811-20. PMID: 17114339.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  16. Qin L, Zeng H, Zhao D. Requirement of protein kinase D tyrosine phosphorylation for VEGF-A165-induced angiogenesis through its interaction and regulation of phospholipase Cgamma phosphorylation. J Biol Chem. 2006 Oct 27; 281(43):32550-8. PMID: 16891660.
    Citations: 23     Fields:    Translation:HumansCells
  17. Zhao D, Zhan Y, Zeng H, Moyer MP, Mantzoros CS, Pothoulakis C. Ghrelin stimulates interleukin-8 gene expression through protein kinase C-mediated NF-kappaB pathway in human colonic epithelial cells. J Cell Biochem. 2006 Apr 15; 97(6):1317-27. PMID: 16552751.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Zeng H, Qin L, Zhao D, Tan X, Manseau EJ, Van Hoang M, Senger DR, Brown LF, Nagy JA, Dvorak HF. Orphan nuclear receptor TR3/Nur77 regulates VEGF-A-induced angiogenesis through its transcriptional activity. J Exp Med. 2006 Mar 20; 203(3):719-29. PMID: 16520388.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  19. Zhao D, Zhan Y, Zeng H, Koon HW, Moyer MP, Pothoulakis C. Neurotensin stimulates interleukin-8 expression through modulation of I kappa B alpha phosphorylation and p65 transcriptional activity: involvement of protein kinase C alpha. Mol Pharmacol. 2005 Jun; 67(6):2025-31. PMID: 15755906.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  20. Mukhopadhyay D, Zeng H, Bhattacharya R. Complexity in the vascular permeability factor/vascular endothelial growth factor (VPF/VEGF)-receptors signaling. Mol Cell Biochem. 2004 Sep; 264(1-2):51-61. PMID: 15544035.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Zhao D, Zhan Y, Koon HW, Zeng H, Keates S, Moyer MP, Pothoulakis C. Metalloproteinase-dependent transforming growth factor-alpha release mediates neurotensin-stimulated MAP kinase activation in human colonic epithelial cells. J Biol Chem. 2004 Oct 15; 279(42):43547-54. PMID: 15247267.
    Citations: 19     Fields:    Translation:HumansCells
  22. Wang L, Zeng H, Wang P, Soker S, Mukhopadhyay D. Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration. J Biol Chem. 2003 Dec 05; 278(49):48848-60. PMID: 14514674.
    Citations: 73     Fields:    Translation:HumansCells
  23. Zeng H, Zhao D, Yang S, Datta K, Mukhopadhyay D. Heterotrimeric G alpha q/G alpha 11 proteins function upstream of vascular endothelial growth factor (VEGF) receptor-2 (KDR) phosphorylation in vascular permeability factor/VEGF signaling. J Biol Chem. 2003 Jun 06; 278(23):20738-45. PMID: 12670961.
    Citations: 23     Fields:    Translation:HumansCells
  24. Zeng H, Datta K, Neid M, Li J, Parangi S, Mukhopadhyay D. Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line. Biochem Biophys Res Commun. 2003 Feb 28; 302(1):46-55. PMID: 12593846.
    Citations: 19     Fields:    Translation:HumansCells
  25. Zhao D, Kuhnt-Moore S, Zeng H, Wu JS, Moyer MP, Pothoulakis C. Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. Am J Physiol Cell Physiol. 2003 Jun; 284(6):C1397-404. PMID: 12584113.
    Citations: 27     Fields:    Translation:HumansCells
  26. Zhao D, Kuhnt-Moore S, Zeng H, Pan A, Wu JS, Simeonidis S, Moyer MP, Pothoulakis C. Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases. Biochem J. 2002 Dec 01; 368(Pt 2):665-72. PMID: 12169092.
    Citations: 25     Fields:    Translation:HumansCells
  27. Zeng H, Zhao D, Mukhopadhyay D. KDR stimulates endothelial cell migration through heterotrimeric G protein Gq/11-mediated activation of a small GTPase RhoA. J Biol Chem. 2002 Nov 29; 277(48):46791-8. PMID: 12244099.
    Citations: 36     Fields:    Translation:HumansCells
  28. Zeng H, Zhao D, Mukhopadhyay D. Flt-1-mediated down-regulation of endothelial cell proliferation through pertussis toxin-sensitive G proteins, beta gamma subunits, small GTPase CDC42, and partly by Rac-1. J Biol Chem. 2002 Feb 08; 277(6):4003-9. PMID: 11726672.
    Citations: 15     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.